-- dump date 20120504_142849 -- class Genbank::misc_feature -- table misc_feature_note -- id note 889513000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 889513000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513000003 Walker A motif; other site 889513000004 ATP binding site [chemical binding]; other site 889513000005 Walker B motif; other site 889513000006 arginine finger; other site 889513000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 889513000008 DnaA box-binding interface [nucleotide binding]; other site 889513000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 889513000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 889513000011 putative DNA binding surface [nucleotide binding]; other site 889513000012 dimer interface [polypeptide binding]; other site 889513000013 beta-clamp/clamp loader binding surface; other site 889513000014 beta-clamp/translesion DNA polymerase binding surface; other site 889513000015 recombination protein F; Reviewed; Region: recF; PRK00064 889513000016 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 889513000017 Walker A/P-loop; other site 889513000018 ATP binding site [chemical binding]; other site 889513000019 Q-loop/lid; other site 889513000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513000021 ABC transporter signature motif; other site 889513000022 Walker B; other site 889513000023 D-loop; other site 889513000024 H-loop/switch region; other site 889513000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 889513000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 889513000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889513000028 ATP binding site [chemical binding]; other site 889513000029 Mg2+ binding site [ion binding]; other site 889513000030 G-X-G motif; other site 889513000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 889513000032 anchoring element; other site 889513000033 dimer interface [polypeptide binding]; other site 889513000034 ATP binding site [chemical binding]; other site 889513000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 889513000036 active site 889513000037 putative metal-binding site [ion binding]; other site 889513000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 889513000039 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 889513000040 metal binding site [ion binding]; metal-binding site 889513000041 DNA gyrase subunit A; Validated; Region: PRK05560 889513000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 889513000043 CAP-like domain; other site 889513000044 active site 889513000045 primary dimer interface [polypeptide binding]; other site 889513000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889513000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889513000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889513000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889513000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889513000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889513000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 889513000053 YwiC-like protein; Region: YwiC; pfam14256 889513000054 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 889513000055 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 889513000056 putative ligand binding site [chemical binding]; other site 889513000057 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 889513000058 TM-ABC transporter signature motif; other site 889513000059 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 889513000060 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 889513000061 Walker A/P-loop; other site 889513000062 ATP binding site [chemical binding]; other site 889513000063 Q-loop/lid; other site 889513000064 ABC transporter signature motif; other site 889513000065 Walker B; other site 889513000066 D-loop; other site 889513000067 H-loop/switch region; other site 889513000068 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 889513000069 active site 889513000070 Rhomboid family; Region: Rhomboid; cl11446 889513000071 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 889513000072 Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576 889513000073 putative active site [active] 889513000074 catalytic site [active] 889513000075 Mg binding site [ion binding]; other site 889513000076 catalytic loop [active] 889513000077 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889513000078 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889513000079 Walker A/P-loop; other site 889513000080 ATP binding site [chemical binding]; other site 889513000081 Q-loop/lid; other site 889513000082 ABC transporter signature motif; other site 889513000083 Walker B; other site 889513000084 D-loop; other site 889513000085 H-loop/switch region; other site 889513000086 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513000087 ABC-ATPase subunit interface; other site 889513000088 dimer interface [polypeptide binding]; other site 889513000089 putative PBP binding regions; other site 889513000090 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513000091 ABC-ATPase subunit interface; other site 889513000092 dimer interface [polypeptide binding]; other site 889513000093 putative PBP binding regions; other site 889513000094 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 889513000095 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 889513000096 siderophore binding site; other site 889513000097 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 889513000098 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 889513000099 active site 889513000100 ATP binding site [chemical binding]; other site 889513000101 substrate binding site [chemical binding]; other site 889513000102 activation loop (A-loop); other site 889513000103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 889513000104 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889513000105 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889513000106 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889513000107 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889513000108 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 889513000109 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 889513000110 active site 889513000111 ATP binding site [chemical binding]; other site 889513000112 substrate binding site [chemical binding]; other site 889513000113 activation loop (A-loop); other site 889513000114 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889513000115 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 889513000116 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 889513000117 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 889513000118 active site 889513000119 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 889513000120 phosphopeptide binding site; other site 889513000121 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 889513000122 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 889513000123 phosphopeptide binding site; other site 889513000124 CAAX protease self-immunity; Region: Abi; cl00558 889513000125 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 889513000126 Helix-turn-helix domains; Region: HTH; cl00088 889513000127 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 889513000128 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889513000129 intersubunit interface [polypeptide binding]; other site 889513000130 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889513000131 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889513000132 Walker A/P-loop; other site 889513000133 ATP binding site [chemical binding]; other site 889513000134 Q-loop/lid; other site 889513000135 ABC transporter signature motif; other site 889513000136 Walker B; other site 889513000137 D-loop; other site 889513000138 H-loop/switch region; other site 889513000139 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513000140 ABC-ATPase subunit interface; other site 889513000141 dimer interface [polypeptide binding]; other site 889513000142 putative PBP binding regions; other site 889513000143 MgtE intracellular N domain; Region: MgtE_N; cl15244 889513000144 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 889513000145 Divalent cation transporter; Region: MgtE; cl00786 889513000146 trehalose synthase; Region: treS_nterm; TIGR02456 889513000147 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 889513000148 active site 889513000149 catalytic site [active] 889513000150 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 889513000151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513000152 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889513000153 putative substrate translocation pore; other site 889513000154 Anti-sigma-K factor rskA; Region: RskA; pfam10099 889513000155 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 889513000156 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889513000157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 889513000158 DNA binding residues [nucleotide binding] 889513000159 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 889513000160 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 889513000161 catalytic residues [active] 889513000162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 889513000163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513000164 dimer interface [polypeptide binding]; other site 889513000165 conserved gate region; other site 889513000166 putative PBP binding loops; other site 889513000167 ABC-ATPase subunit interface; other site 889513000168 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 889513000169 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513000170 Walker A/P-loop; other site 889513000171 ATP binding site [chemical binding]; other site 889513000172 Q-loop/lid; other site 889513000173 ABC transporter signature motif; other site 889513000174 Walker B; other site 889513000175 D-loop; other site 889513000176 H-loop/switch region; other site 889513000177 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 889513000178 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 889513000179 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 889513000180 putative metal binding site [ion binding]; other site 889513000181 biotin synthase; Validated; Region: PRK06256 889513000182 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889513000183 FeS/SAM binding site; other site 889513000184 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 889513000185 MepB protein; Region: MepB; cl01985 889513000186 AMP nucleosidase; Provisional; Region: PRK08292 889513000187 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 889513000188 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 889513000189 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 889513000190 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 889513000191 active site 889513000192 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 889513000193 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 889513000194 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513000195 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 889513000196 dimer interface [polypeptide binding]; other site 889513000197 FMN binding site [chemical binding]; other site 889513000198 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 889513000199 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 889513000200 trimer interface [polypeptide binding]; other site 889513000201 putative metal binding site [ion binding]; other site 889513000202 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889513000203 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 889513000204 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 889513000205 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 889513000206 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513000207 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 889513000208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 889513000209 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889513000210 Helix-turn-helix domains; Region: HTH; cl00088 889513000211 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 889513000212 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 889513000213 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 889513000214 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 889513000215 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889513000216 active site 889513000217 phosphorylation site [posttranslational modification] 889513000218 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 889513000219 active site 889513000220 P-loop; other site 889513000221 phosphorylation site [posttranslational modification] 889513000222 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 889513000223 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 889513000224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513000225 ATP binding site [chemical binding]; other site 889513000226 putative Mg++ binding site [ion binding]; other site 889513000227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513000228 nucleotide binding region [chemical binding]; other site 889513000229 ATP-binding site [chemical binding]; other site 889513000230 Helicase associated domain (HA2); Region: HA2; cl04503 889513000231 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 889513000232 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 889513000233 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 889513000234 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 889513000235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513000236 NAD(P) binding site [chemical binding]; other site 889513000237 active site 889513000238 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 889513000239 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 889513000240 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 889513000241 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889513000242 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 889513000243 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 889513000244 DNA binding site [nucleotide binding] 889513000245 active site 889513000246 Domain of unknown function (DUF222); Region: DUF222; pfam02720 889513000247 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 889513000248 active site 889513000249 glycerol kinase; Provisional; Region: glpK; PRK00047 889513000250 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 889513000251 N- and C-terminal domain interface [polypeptide binding]; other site 889513000252 active site 889513000253 MgATP binding site [chemical binding]; other site 889513000254 catalytic site [active] 889513000255 metal binding site [ion binding]; metal-binding site 889513000256 carbohydrate binding site [chemical binding]; other site 889513000257 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 889513000258 amphipathic channel; other site 889513000259 Asn-Pro-Ala signature motifs; other site 889513000260 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 889513000261 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 889513000262 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 889513000263 active site 889513000264 Zn binding site [ion binding]; other site 889513000265 Protease prsW family; Region: PrsW-protease; cl15823 889513000266 NMT1-like family; Region: NMT1_2; cl15260 889513000267 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 889513000268 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 889513000269 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 889513000270 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 889513000271 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 889513000272 classical (c) SDRs; Region: SDR_c; cd05233 889513000273 NAD(P) binding site [chemical binding]; other site 889513000274 active site 889513000275 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 889513000276 FAD binding domain; Region: FAD_binding_4; pfam01565 889513000277 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 889513000278 GtrA-like protein; Region: GtrA; cl00971 889513000279 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 889513000280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 889513000281 active site 889513000282 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 889513000283 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 889513000284 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 889513000285 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 889513000286 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513000287 ABC-ATPase subunit interface; other site 889513000288 dimer interface [polypeptide binding]; other site 889513000289 putative PBP binding regions; other site 889513000290 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889513000291 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 889513000292 intersubunit interface [polypeptide binding]; other site 889513000293 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 889513000294 active site 889513000295 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 889513000296 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 889513000297 Walker A/P-loop; other site 889513000298 ATP binding site [chemical binding]; other site 889513000299 Q-loop/lid; other site 889513000300 ABC transporter signature motif; other site 889513000301 Walker B; other site 889513000302 D-loop; other site 889513000303 H-loop/switch region; other site 889513000304 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889513000305 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 889513000306 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889513000307 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889513000308 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 889513000309 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 889513000310 NAD(P) binding site [chemical binding]; other site 889513000311 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 889513000312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889513000313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513000314 homodimer interface [polypeptide binding]; other site 889513000315 catalytic residue [active] 889513000316 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 889513000317 transmembrane helices; other site 889513000318 CAT RNA binding domain; Region: CAT_RBD; cl03904 889513000319 PRD domain; Region: PRD; cl15445 889513000320 PRD domain; Region: PRD; cl15445 889513000321 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 889513000322 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889513000323 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 889513000324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889513000325 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 889513000326 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 889513000327 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 889513000328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889513000329 DNA-binding site [nucleotide binding]; DNA binding site 889513000330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889513000331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513000332 homodimer interface [polypeptide binding]; other site 889513000333 catalytic residue [active] 889513000334 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 889513000335 active site 889513000336 multimer interface [polypeptide binding]; other site 889513000337 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 889513000338 predicted active site [active] 889513000339 catalytic triad [active] 889513000340 prephenate dehydrogenase; Validated; Region: PRK06545 889513000341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513000342 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 889513000343 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 889513000344 nucleoside/Zn binding site; other site 889513000345 dimer interface [polypeptide binding]; other site 889513000346 catalytic motif [active] 889513000347 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 889513000348 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 889513000349 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 889513000350 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 889513000351 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889513000352 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889513000353 active site 889513000354 KMSKS motif; other site 889513000355 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 889513000356 GntP family permease; Region: GntP_permease; pfam02447 889513000357 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 889513000358 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 889513000359 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 889513000360 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 889513000361 putative NAD(P) binding site [chemical binding]; other site 889513000362 catalytic Zn binding site [ion binding]; other site 889513000363 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 889513000364 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 889513000365 NADP binding site [chemical binding]; other site 889513000366 homodimer interface [polypeptide binding]; other site 889513000367 active site 889513000368 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 889513000369 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889513000370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513000371 homodimer interface [polypeptide binding]; other site 889513000372 catalytic residue [active] 889513000373 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 889513000374 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 889513000375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513000376 Walker A motif; other site 889513000377 ATP binding site [chemical binding]; other site 889513000378 Walker B motif; other site 889513000379 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889513000380 arginine finger; other site 889513000381 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 889513000382 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 889513000383 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 889513000384 recombination protein RecR; Reviewed; Region: recR; PRK00076 889513000385 RecR protein; Region: RecR; pfam02132 889513000386 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 889513000387 putative active site [active] 889513000388 putative metal-binding site [ion binding]; other site 889513000389 tetramer interface [polypeptide binding]; other site 889513000390 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 889513000391 GntP family permease; Region: GntP_permease; pfam02447 889513000392 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 889513000393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513000394 Transcriptional regulators [Transcription]; Region: FadR; COG2186 889513000395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889513000396 DNA-binding site [nucleotide binding]; DNA binding site 889513000397 FCD domain; Region: FCD; cl11656 889513000398 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 889513000399 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 889513000400 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 889513000401 catalytic triad [active] 889513000402 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 889513000403 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889513000404 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 889513000405 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 889513000406 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 889513000407 active site 889513000408 catalytic site [active] 889513000409 substrate binding site [chemical binding]; other site 889513000410 2-isopropylmalate synthase; Validated; Region: PRK03739 889513000411 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 889513000412 active site 889513000413 catalytic residues [active] 889513000414 metal binding site [ion binding]; metal-binding site 889513000415 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 889513000416 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 889513000417 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 889513000418 DNA binding residues [nucleotide binding] 889513000419 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 889513000420 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 889513000421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513000422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889513000423 putative substrate translocation pore; other site 889513000424 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 889513000425 intersubunit interface [polypeptide binding]; other site 889513000426 active site 889513000427 catalytic residue [active] 889513000428 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 889513000429 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 889513000430 active site 889513000431 substrate binding site [chemical binding]; other site 889513000432 metal binding site [ion binding]; metal-binding site 889513000433 TQXA domain; Region: TQXA_dom; TIGR03934 889513000434 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 889513000435 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 889513000436 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 889513000437 aspartate kinase; Reviewed; Region: PRK06635 889513000438 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 889513000439 putative nucleotide binding site [chemical binding]; other site 889513000440 putative catalytic residues [active] 889513000441 putative Mg ion binding site [ion binding]; other site 889513000442 putative aspartate binding site [chemical binding]; other site 889513000443 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 889513000444 putative allosteric regulatory site; other site 889513000445 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 889513000446 putative allosteric regulatory residue; other site 889513000447 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 889513000448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513000449 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 889513000450 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889513000451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889513000452 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 889513000453 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 889513000454 heme binding pocket [chemical binding]; other site 889513000455 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 889513000456 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 889513000457 Walker A/P-loop; other site 889513000458 ATP binding site [chemical binding]; other site 889513000459 Q-loop/lid; other site 889513000460 ABC transporter signature motif; other site 889513000461 Walker B; other site 889513000462 D-loop; other site 889513000463 H-loop/switch region; other site 889513000464 TOBE domain; Region: TOBE_2; cl01440 889513000465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513000466 dimer interface [polypeptide binding]; other site 889513000467 conserved gate region; other site 889513000468 ABC-ATPase subunit interface; other site 889513000469 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 889513000470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513000471 putative substrate translocation pore; other site 889513000472 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889513000473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889513000474 active site 889513000475 phosphorylation site [posttranslational modification] 889513000476 intermolecular recognition site; other site 889513000477 dimerization interface [polypeptide binding]; other site 889513000478 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889513000479 DNA binding site [nucleotide binding] 889513000480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889513000481 dimer interface [polypeptide binding]; other site 889513000482 phosphorylation site [posttranslational modification] 889513000483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889513000484 ATP binding site [chemical binding]; other site 889513000485 Mg2+ binding site [ion binding]; other site 889513000486 G-X-G motif; other site 889513000487 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 889513000488 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 889513000489 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 889513000490 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 889513000491 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 889513000492 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 889513000493 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 889513000494 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 889513000495 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 889513000496 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 889513000497 Predicted membrane protein [Function unknown]; Region: COG1511 889513000498 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 889513000499 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 889513000500 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 889513000501 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 889513000502 putative active site [active] 889513000503 putative metal binding site [ion binding]; other site 889513000504 GatB domain; Region: GatB_Yqey; cl11497 889513000505 Transglycosylase; Region: Transgly; cl07896 889513000506 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 889513000507 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889513000508 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 889513000509 Transcription factor WhiB; Region: Whib; pfam02467 889513000510 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 889513000511 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 889513000512 homotrimer interaction site [polypeptide binding]; other site 889513000513 putative active site [active] 889513000514 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889513000515 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 889513000516 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 889513000517 ligand binding site [chemical binding]; other site 889513000518 flexible hinge region; other site 889513000519 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 889513000520 putative switch regulator; other site 889513000521 non-specific DNA interactions [nucleotide binding]; other site 889513000522 DNA binding site [nucleotide binding] 889513000523 sequence specific DNA binding site [nucleotide binding]; other site 889513000524 putative cAMP binding site [chemical binding]; other site 889513000525 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 889513000526 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 889513000527 minor groove reading motif; other site 889513000528 helix-hairpin-helix signature motif; other site 889513000529 substrate binding pocket [chemical binding]; other site 889513000530 active site 889513000531 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 889513000532 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 889513000533 catalytic residues [active] 889513000534 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 889513000535 putative active site [active] 889513000536 putative CoA binding site [chemical binding]; other site 889513000537 nudix motif; other site 889513000538 metal binding site [ion binding]; metal-binding site 889513000539 Colicin V production protein; Region: Colicin_V; cl00567 889513000540 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 889513000541 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513000542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 889513000543 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 889513000544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889513000545 motif II; other site 889513000546 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 889513000547 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 889513000548 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 889513000549 ATP binding site [chemical binding]; other site 889513000550 Walker A motif; other site 889513000551 hexamer interface [polypeptide binding]; other site 889513000552 Walker B motif; other site 889513000553 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 889513000554 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 889513000555 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 889513000556 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 889513000557 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513000558 ATP binding site [chemical binding]; other site 889513000559 putative Mg++ binding site [ion binding]; other site 889513000560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513000561 nucleotide binding region [chemical binding]; other site 889513000562 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 889513000563 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 889513000564 DNA-binding site [nucleotide binding]; DNA binding site 889513000565 RNA-binding motif; other site 889513000566 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 889513000567 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 889513000568 active site 889513000569 interdomain interaction site; other site 889513000570 putative metal-binding site [ion binding]; other site 889513000571 nucleotide binding site [chemical binding]; other site 889513000572 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 889513000573 domain I; other site 889513000574 phosphate binding site [ion binding]; other site 889513000575 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 889513000576 domain II; other site 889513000577 domain III; other site 889513000578 nucleotide binding site [chemical binding]; other site 889513000579 DNA binding groove [nucleotide binding] 889513000580 catalytic site [active] 889513000581 domain IV; other site 889513000582 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 889513000583 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 889513000584 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 889513000585 oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728 889513000586 OPT oligopeptide transporter protein; Region: OPT; cl14607 889513000587 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 889513000588 dimerization interface [polypeptide binding]; other site 889513000589 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 889513000590 cyclase homology domain; Region: CHD; cd07302 889513000591 nucleotidyl binding site; other site 889513000592 metal binding site [ion binding]; metal-binding site 889513000593 dimer interface [polypeptide binding]; other site 889513000594 DNA polymerase III subunit delta'; Validated; Region: PRK07940 889513000595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513000596 acyl-CoA synthetase; Validated; Region: PRK07788 889513000597 AMP-binding enzyme; Region: AMP-binding; cl15778 889513000598 AMP-binding enzyme; Region: AMP-binding; cl15778 889513000599 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 889513000600 active site 889513000601 catalytic triad [active] 889513000602 oxyanion hole [active] 889513000603 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 889513000604 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 889513000605 substrate binding site; other site 889513000606 tetramer interface; other site 889513000607 Cupin domain; Region: Cupin_2; cl09118 889513000608 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 889513000609 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 889513000610 NADP binding site [chemical binding]; other site 889513000611 active site 889513000612 putative substrate binding site [chemical binding]; other site 889513000613 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 889513000614 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 889513000615 NAD binding site [chemical binding]; other site 889513000616 substrate binding site [chemical binding]; other site 889513000617 homodimer interface [polypeptide binding]; other site 889513000618 active site 889513000619 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 889513000620 Zn binding site [ion binding]; other site 889513000621 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 889513000622 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513000623 Predicted esterase [General function prediction only]; Region: COG0627 889513000624 Peptidase family S64; Region: Peptidase_S64; pfam08192 889513000625 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 889513000626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513000627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889513000628 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889513000629 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 889513000630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889513000631 non-specific DNA binding site [nucleotide binding]; other site 889513000632 salt bridge; other site 889513000633 sequence-specific DNA binding site [nucleotide binding]; other site 889513000634 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 889513000635 Domain of unknown function (DUF955); Region: DUF955; cl01076 889513000636 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 889513000637 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 889513000638 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 889513000639 putative Iron-sulfur protein interface [polypeptide binding]; other site 889513000640 proximal heme binding site [chemical binding]; other site 889513000641 distal heme binding site [chemical binding]; other site 889513000642 putative dimer interface [polypeptide binding]; other site 889513000643 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 889513000644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513000645 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 889513000646 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 889513000647 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 889513000648 Predicted membrane protein [Function unknown]; Region: COG2733 889513000649 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 889513000650 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 889513000651 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 889513000652 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 889513000653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889513000654 FeS/SAM binding site; other site 889513000655 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 889513000656 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 889513000657 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 889513000658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513000659 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 889513000660 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 889513000661 FAD binding domain; Region: FAD_binding_4; pfam01565 889513000662 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 889513000663 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 889513000664 AMP-binding enzyme; Region: AMP-binding; cl15778 889513000665 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 889513000666 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 889513000667 putative ADP-binding pocket [chemical binding]; other site 889513000668 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889513000669 catalytic core [active] 889513000670 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889513000671 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 889513000672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889513000673 dimer interface [polypeptide binding]; other site 889513000674 phosphorylation site [posttranslational modification] 889513000675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889513000676 ATP binding site [chemical binding]; other site 889513000677 Mg2+ binding site [ion binding]; other site 889513000678 G-X-G motif; other site 889513000679 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889513000680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889513000681 active site 889513000682 phosphorylation site [posttranslational modification] 889513000683 intermolecular recognition site; other site 889513000684 dimerization interface [polypeptide binding]; other site 889513000685 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889513000686 DNA binding site [nucleotide binding] 889513000687 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 889513000688 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 889513000689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513000690 NAD(P) binding pocket [chemical binding]; other site 889513000691 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 889513000692 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 889513000693 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 889513000694 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 889513000695 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889513000696 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 889513000697 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 889513000698 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 889513000699 tRNA; other site 889513000700 putative tRNA binding site [nucleotide binding]; other site 889513000701 putative NADP binding site [chemical binding]; other site 889513000702 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 889513000703 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 889513000704 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 889513000705 domain interfaces; other site 889513000706 active site 889513000707 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 889513000708 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 889513000709 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 889513000710 active site 889513000711 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 889513000712 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 889513000713 dimer interface [polypeptide binding]; other site 889513000714 active site 889513000715 Schiff base residues; other site 889513000716 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 889513000717 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889513000718 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 889513000719 substrate binding site [chemical binding]; other site 889513000720 active site 889513000721 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 889513000722 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 889513000723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513000724 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 889513000725 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889513000726 inhibitor-cofactor binding pocket; inhibition site 889513000727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513000728 catalytic residue [active] 889513000729 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889513000730 catalytic core [active] 889513000731 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 889513000732 catalytic residues [active] 889513000733 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 889513000734 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 889513000735 ResB-like family; Region: ResB; pfam05140 889513000736 Methyltransferase domain; Region: Methyltransf_31; pfam13847 889513000737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513000738 S-adenosylmethionine binding site [chemical binding]; other site 889513000739 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889513000740 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889513000741 Walker A/P-loop; other site 889513000742 ATP binding site [chemical binding]; other site 889513000743 Q-loop/lid; other site 889513000744 ABC transporter signature motif; other site 889513000745 Walker B; other site 889513000746 D-loop; other site 889513000747 H-loop/switch region; other site 889513000748 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 889513000749 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889513000750 intersubunit interface [polypeptide binding]; other site 889513000751 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 889513000752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513000753 ABC-ATPase subunit interface; other site 889513000754 dimer interface [polypeptide binding]; other site 889513000755 putative PBP binding regions; other site 889513000756 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 889513000757 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 889513000758 UbiA prenyltransferase family; Region: UbiA; cl00337 889513000759 AMP-binding enzyme; Region: AMP-binding; cl15778 889513000760 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 889513000761 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 889513000762 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 889513000763 substrate binding site [chemical binding]; other site 889513000764 oxyanion hole (OAH) forming residues; other site 889513000765 trimer interface [polypeptide binding]; other site 889513000766 O-succinylbenzoate synthase; Provisional; Region: PRK02901 889513000767 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 889513000768 active site 889513000769 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 889513000770 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 889513000771 dimer interface [polypeptide binding]; other site 889513000772 tetramer interface [polypeptide binding]; other site 889513000773 PYR/PP interface [polypeptide binding]; other site 889513000774 TPP binding site [chemical binding]; other site 889513000775 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 889513000776 TPP-binding site; other site 889513000777 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 889513000778 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889513000779 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 889513000780 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 889513000781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513000782 S-adenosylmethionine binding site [chemical binding]; other site 889513000783 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 889513000784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513000785 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 889513000786 NAD(P) binding site [chemical binding]; other site 889513000787 LDH/MDH dimer interface [polypeptide binding]; other site 889513000788 substrate binding site [chemical binding]; other site 889513000789 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 889513000790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513000791 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 889513000792 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 889513000793 substrate binding pocket [chemical binding]; other site 889513000794 chain length determination region; other site 889513000795 substrate-Mg2+ binding site; other site 889513000796 catalytic residues [active] 889513000797 aspartate-rich region 1; other site 889513000798 active site lid residues [active] 889513000799 aspartate-rich region 2; other site 889513000800 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 889513000801 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 889513000802 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 889513000803 putative homodimer interface [polypeptide binding]; other site 889513000804 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 889513000805 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 889513000806 23S rRNA interface [nucleotide binding]; other site 889513000807 L7/L12 interface [polypeptide binding]; other site 889513000808 putative thiostrepton binding site; other site 889513000809 L25 interface [polypeptide binding]; other site 889513000810 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 889513000811 mRNA/rRNA interface [nucleotide binding]; other site 889513000812 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 889513000813 trimer interface [polypeptide binding]; other site 889513000814 active site 889513000815 G bulge; other site 889513000816 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 889513000817 FMN binding site [chemical binding]; other site 889513000818 active site 889513000819 substrate binding site [chemical binding]; other site 889513000820 catalytic residue [active] 889513000821 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 889513000822 23S rRNA interface [nucleotide binding]; other site 889513000823 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 889513000824 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 889513000825 L11 interface [polypeptide binding]; other site 889513000826 putative EF-Tu interaction site [polypeptide binding]; other site 889513000827 putative EF-G interaction site [polypeptide binding]; other site 889513000828 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 889513000829 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 889513000830 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 889513000831 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889513000832 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 889513000833 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889513000834 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 889513000835 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 889513000836 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 889513000837 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 889513000838 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 889513000839 ABC-ATPase subunit interface; other site 889513000840 dimer interface [polypeptide binding]; other site 889513000841 putative PBP binding regions; other site 889513000842 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 889513000843 Ethylene insensitive 3; Region: EIN3; cl04813 889513000844 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 889513000845 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 889513000846 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 889513000847 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 889513000848 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 889513000849 RPB1 interaction site [polypeptide binding]; other site 889513000850 RPB10 interaction site [polypeptide binding]; other site 889513000851 RPB11 interaction site [polypeptide binding]; other site 889513000852 RPB3 interaction site [polypeptide binding]; other site 889513000853 RPB12 interaction site [polypeptide binding]; other site 889513000854 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 889513000855 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 889513000856 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 889513000857 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 889513000858 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 889513000859 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 889513000860 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 889513000861 G-loop; other site 889513000862 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 889513000863 DNA binding site [nucleotide binding] 889513000864 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 889513000865 Histidine kinase; Region: HisKA_3; pfam07730 889513000866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 889513000867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 889513000868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889513000869 active site 889513000870 phosphorylation site [posttranslational modification] 889513000871 intermolecular recognition site; other site 889513000872 dimerization interface [polypeptide binding]; other site 889513000873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889513000874 DNA binding residues [nucleotide binding] 889513000875 dimerization interface [polypeptide binding]; other site 889513000876 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889513000877 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 889513000878 Predicted permeases [General function prediction only]; Region: COG0701 889513000879 Predicted permease; Region: DUF318; pfam03773 889513000880 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 889513000881 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889513000882 FeS/SAM binding site; other site 889513000883 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 889513000884 Class III ribonucleotide reductase; Region: RNR_III; cd01675 889513000885 effector binding site; other site 889513000886 active site 889513000887 Zn binding site [ion binding]; other site 889513000888 glycine loop; other site 889513000889 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 889513000890 S17 interaction site [polypeptide binding]; other site 889513000891 S8 interaction site; other site 889513000892 16S rRNA interaction site [nucleotide binding]; other site 889513000893 streptomycin interaction site [chemical binding]; other site 889513000894 23S rRNA interaction site [nucleotide binding]; other site 889513000895 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 889513000896 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 889513000897 elongation factor G; Reviewed; Region: PRK00007 889513000898 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 889513000899 G1 box; other site 889513000900 putative GEF interaction site [polypeptide binding]; other site 889513000901 GTP/Mg2+ binding site [chemical binding]; other site 889513000902 Switch I region; other site 889513000903 G2 box; other site 889513000904 G3 box; other site 889513000905 Switch II region; other site 889513000906 G4 box; other site 889513000907 G5 box; other site 889513000908 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 889513000909 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 889513000910 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 889513000911 elongation factor Tu; Reviewed; Region: PRK00049 889513000912 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 889513000913 G1 box; other site 889513000914 GEF interaction site [polypeptide binding]; other site 889513000915 GTP/Mg2+ binding site [chemical binding]; other site 889513000916 Switch I region; other site 889513000917 G2 box; other site 889513000918 G3 box; other site 889513000919 Switch II region; other site 889513000920 G4 box; other site 889513000921 G5 box; other site 889513000922 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 889513000923 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 889513000924 Antibiotic Binding Site [chemical binding]; other site 889513000925 Asp23 family; Region: Asp23; cl00574 889513000926 Asp23 family; Region: Asp23; cl00574 889513000927 Asp23 family; Region: Asp23; cl00574 889513000928 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 889513000929 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 889513000930 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 889513000931 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 889513000932 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 889513000933 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 889513000934 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 889513000935 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 889513000936 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 889513000937 putative translocon binding site; other site 889513000938 protein-rRNA interface [nucleotide binding]; other site 889513000939 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 889513000940 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 889513000941 G-X-X-G motif; other site 889513000942 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 889513000943 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 889513000944 23S rRNA interface [nucleotide binding]; other site 889513000945 5S rRNA interface [nucleotide binding]; other site 889513000946 putative antibiotic binding site [chemical binding]; other site 889513000947 L25 interface [polypeptide binding]; other site 889513000948 L27 interface [polypeptide binding]; other site 889513000949 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 889513000950 putative translocon interaction site; other site 889513000951 23S rRNA interface [nucleotide binding]; other site 889513000952 signal recognition particle (SRP54) interaction site; other site 889513000953 L23 interface [polypeptide binding]; other site 889513000954 trigger factor interaction site; other site 889513000955 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 889513000956 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 889513000957 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 889513000958 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 889513000959 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513000960 Walker A/P-loop; other site 889513000961 ATP binding site [chemical binding]; other site 889513000962 Q-loop/lid; other site 889513000963 ABC transporter signature motif; other site 889513000964 Walker B; other site 889513000965 D-loop; other site 889513000966 H-loop/switch region; other site 889513000967 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889513000968 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513000969 Walker A/P-loop; other site 889513000970 ATP binding site [chemical binding]; other site 889513000971 Q-loop/lid; other site 889513000972 ABC transporter signature motif; other site 889513000973 Walker B; other site 889513000974 D-loop; other site 889513000975 H-loop/switch region; other site 889513000976 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889513000977 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 889513000978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513000979 dimer interface [polypeptide binding]; other site 889513000980 conserved gate region; other site 889513000981 putative PBP binding loops; other site 889513000982 ABC-ATPase subunit interface; other site 889513000983 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889513000984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513000985 putative PBP binding loops; other site 889513000986 dimer interface [polypeptide binding]; other site 889513000987 ABC-ATPase subunit interface; other site 889513000988 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 889513000989 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 889513000990 KOW motif; Region: KOW; cl00354 889513000991 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 889513000992 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 889513000993 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 889513000994 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 889513000995 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 889513000996 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 889513000997 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 889513000998 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 889513000999 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 889513001000 active site 889513001001 homotetramer interface [polypeptide binding]; other site 889513001002 homodimer interface [polypeptide binding]; other site 889513001003 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 889513001004 active site 889513001005 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 889513001006 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 889513001007 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 889513001008 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 889513001009 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 889513001010 5S rRNA interface [nucleotide binding]; other site 889513001011 23S rRNA interface [nucleotide binding]; other site 889513001012 L5 interface [polypeptide binding]; other site 889513001013 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 889513001014 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 889513001015 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 889513001016 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 889513001017 23S rRNA binding site [nucleotide binding]; other site 889513001018 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 889513001019 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 889513001020 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889513001021 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 889513001022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513001023 dimer interface [polypeptide binding]; other site 889513001024 conserved gate region; other site 889513001025 putative PBP binding loops; other site 889513001026 ABC-ATPase subunit interface; other site 889513001027 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 889513001028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513001029 dimer interface [polypeptide binding]; other site 889513001030 conserved gate region; other site 889513001031 putative PBP binding loops; other site 889513001032 ABC-ATPase subunit interface; other site 889513001033 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 889513001034 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 889513001035 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 889513001036 Walker A/P-loop; other site 889513001037 ATP binding site [chemical binding]; other site 889513001038 Q-loop/lid; other site 889513001039 ABC transporter signature motif; other site 889513001040 Walker B; other site 889513001041 D-loop; other site 889513001042 H-loop/switch region; other site 889513001043 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 889513001044 SecY translocase; Region: SecY; pfam00344 889513001045 adenylate kinase; Reviewed; Region: adk; PRK00279 889513001046 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 889513001047 AMP-binding site [chemical binding]; other site 889513001048 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 889513001049 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 889513001050 catalytic site [active] 889513001051 BNR repeat-like domain; Region: BNR_2; pfam13088 889513001052 Asp-box motif; other site 889513001053 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 889513001054 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 889513001055 rRNA binding site [nucleotide binding]; other site 889513001056 predicted 30S ribosome binding site; other site 889513001057 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 889513001058 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 889513001059 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 889513001060 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 889513001061 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 889513001062 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889513001063 RNA binding surface [nucleotide binding]; other site 889513001064 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 889513001065 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 889513001066 alphaNTD - beta interaction site [polypeptide binding]; other site 889513001067 alphaNTD homodimer interface [polypeptide binding]; other site 889513001068 alphaNTD - beta' interaction site [polypeptide binding]; other site 889513001069 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 889513001070 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 889513001071 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 889513001072 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 889513001073 dimerization interface 3.5A [polypeptide binding]; other site 889513001074 active site 889513001075 Protein of unknown function (DUF690); Region: DUF690; cl04939 889513001076 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 889513001077 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 889513001078 active site 889513001079 catalytic residues [active] 889513001080 Ubiquitin-like proteins; Region: UBQ; cl00155 889513001081 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 889513001082 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513001083 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 889513001084 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513001085 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513001086 Walker A/P-loop; other site 889513001087 ATP binding site [chemical binding]; other site 889513001088 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 889513001089 Proteins of 100 residues with WXG; Region: WXG100; cl02005 889513001090 Proteins of 100 residues with WXG; Region: WXG100; cl02005 889513001091 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 889513001092 23S rRNA interface [nucleotide binding]; other site 889513001093 L3 interface [polypeptide binding]; other site 889513001094 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 889513001095 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 889513001096 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 889513001097 active site 889513001098 substrate binding site [chemical binding]; other site 889513001099 metal binding site [ion binding]; metal-binding site 889513001100 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 889513001101 alanine racemase; Reviewed; Region: alr; PRK00053 889513001102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 889513001103 active site 889513001104 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889513001105 dimer interface [polypeptide binding]; other site 889513001106 substrate binding site [chemical binding]; other site 889513001107 catalytic residues [active] 889513001108 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 889513001109 Predicted permease [General function prediction only]; Region: COG2985 889513001110 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 889513001111 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889513001112 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 889513001113 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 889513001114 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 889513001115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889513001116 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513001117 Coenzyme A binding pocket [chemical binding]; other site 889513001118 UGMP family protein; Validated; Region: PRK09604 889513001119 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 889513001120 oligomerisation interface [polypeptide binding]; other site 889513001121 mobile loop; other site 889513001122 roof hairpin; other site 889513001123 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 889513001124 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 889513001125 ring oligomerisation interface [polypeptide binding]; other site 889513001126 ATP/Mg binding site [chemical binding]; other site 889513001127 stacking interactions; other site 889513001128 hinge regions; other site 889513001129 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 889513001130 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889513001131 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 889513001132 DNA binding residues [nucleotide binding] 889513001133 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 889513001134 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 889513001135 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 889513001136 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 889513001137 active site 889513001138 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 889513001139 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 889513001140 phosphate binding site [ion binding]; other site 889513001141 Amino acid permease; Region: AA_permease_2; pfam13520 889513001142 GMP synthase; Reviewed; Region: guaA; PRK00074 889513001143 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 889513001144 AMP/PPi binding site [chemical binding]; other site 889513001145 candidate oxyanion hole; other site 889513001146 catalytic triad [active] 889513001147 potential glutamine specificity residues [chemical binding]; other site 889513001148 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 889513001149 ATP Binding subdomain [chemical binding]; other site 889513001150 Ligand Binding sites [chemical binding]; other site 889513001151 Dimerization subdomain; other site 889513001152 PspC domain; Region: PspC; cl00864 889513001153 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 889513001154 PspC domain; Region: PspC; cl00864 889513001155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 889513001156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 889513001157 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 889513001158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889513001159 active site 889513001160 phosphorylation site [posttranslational modification] 889513001161 intermolecular recognition site; other site 889513001162 dimerization interface [polypeptide binding]; other site 889513001163 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889513001164 dimerization interface [polypeptide binding]; other site 889513001165 DNA binding residues [nucleotide binding] 889513001166 AMIN domain; Region: AMIN; pfam11741 889513001167 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 889513001168 putative dimer interface [polypeptide binding]; other site 889513001169 putative [2Fe-2S] cluster binding site [ion binding]; other site 889513001170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 889513001171 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 889513001172 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 889513001173 Walker A/P-loop; other site 889513001174 ATP binding site [chemical binding]; other site 889513001175 Q-loop/lid; other site 889513001176 ABC transporter signature motif; other site 889513001177 Walker B; other site 889513001178 D-loop; other site 889513001179 H-loop/switch region; other site 889513001180 NMT1-like family; Region: NMT1_2; cl15260 889513001181 NMT1-like family; Region: NMT1_2; cl15260 889513001182 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889513001183 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 889513001184 intersubunit interface [polypeptide binding]; other site 889513001185 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 889513001186 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 889513001187 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513001188 ABC-ATPase subunit interface; other site 889513001189 dimer interface [polypeptide binding]; other site 889513001190 putative PBP binding regions; other site 889513001191 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 889513001192 ABC-ATPase subunit interface; other site 889513001193 dimer interface [polypeptide binding]; other site 889513001194 putative PBP binding regions; other site 889513001195 Helix-turn-helix domains; Region: HTH; cl00088 889513001196 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 889513001197 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 889513001198 FeoA domain; Region: FeoA; cl00838 889513001199 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 889513001200 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 889513001201 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 889513001202 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 889513001203 homodimer interface [polypeptide binding]; other site 889513001204 NADP binding site [chemical binding]; other site 889513001205 substrate binding site [chemical binding]; other site 889513001206 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 889513001207 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 889513001208 active site 889513001209 Htaa; Region: HtaA; pfam04213 889513001210 Htaa; Region: HtaA; pfam04213 889513001211 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 889513001212 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889513001213 intersubunit interface [polypeptide binding]; other site 889513001214 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 889513001215 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513001216 ABC-ATPase subunit interface; other site 889513001217 dimer interface [polypeptide binding]; other site 889513001218 putative PBP binding regions; other site 889513001219 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 889513001220 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889513001221 Walker A/P-loop; other site 889513001222 ATP binding site [chemical binding]; other site 889513001223 Q-loop/lid; other site 889513001224 ABC transporter signature motif; other site 889513001225 Walker B; other site 889513001226 D-loop; other site 889513001227 H-loop/switch region; other site 889513001228 Htaa; Region: HtaA; pfam04213 889513001229 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 889513001230 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 889513001231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513001232 putative substrate translocation pore; other site 889513001233 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 889513001234 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 889513001235 DNA binding residues [nucleotide binding] 889513001236 dimer interface [polypeptide binding]; other site 889513001237 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 889513001238 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 889513001239 putative catalytic site [active] 889513001240 putative metal binding site [ion binding]; other site 889513001241 putative phosphate binding site [ion binding]; other site 889513001242 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 889513001243 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 889513001244 active site 889513001245 HIGH motif; other site 889513001246 dimer interface [polypeptide binding]; other site 889513001247 KMSKS motif; other site 889513001248 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 889513001249 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 889513001250 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889513001251 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 889513001252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889513001253 active site 889513001254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889513001255 non-specific DNA binding site [nucleotide binding]; other site 889513001256 salt bridge; other site 889513001257 sequence-specific DNA binding site [nucleotide binding]; other site 889513001258 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 889513001259 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 889513001260 active site 889513001261 substrate binding site [chemical binding]; other site 889513001262 metal binding site [ion binding]; metal-binding site 889513001263 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 889513001264 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 889513001265 metal binding site [ion binding]; metal-binding site 889513001266 putative dimer interface [polypeptide binding]; other site 889513001267 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 889513001268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513001269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889513001270 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889513001271 pyruvate carboxylase; Reviewed; Region: PRK12999 889513001272 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889513001273 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889513001274 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 889513001275 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 889513001276 active site 889513001277 catalytic residues [active] 889513001278 metal binding site [ion binding]; metal-binding site 889513001279 homodimer binding site [polypeptide binding]; other site 889513001280 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889513001281 carboxyltransferase (CT) interaction site; other site 889513001282 biotinylation site [posttranslational modification]; other site 889513001283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513001284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513001285 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 889513001286 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889513001287 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889513001288 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 889513001289 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889513001290 carboxyltransferase (CT) interaction site; other site 889513001291 biotinylation site [posttranslational modification]; other site 889513001292 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 889513001293 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 889513001294 active site residue [active] 889513001295 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 889513001296 active site residue [active] 889513001297 OpgC protein; Region: OpgC_C; cl00792 889513001298 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 889513001299 Maf-like protein; Region: Maf; pfam02545 889513001300 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 889513001301 active site 889513001302 dimer interface [polypeptide binding]; other site 889513001303 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 889513001304 substrate binding site [chemical binding]; other site 889513001305 ATP binding site [chemical binding]; other site 889513001306 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889513001307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889513001308 DNA binding site [nucleotide binding] 889513001309 domain linker motif; other site 889513001310 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 889513001311 putative ligand binding site [chemical binding]; other site 889513001312 dimerization interface [polypeptide binding]; other site 889513001313 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 889513001314 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 889513001315 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889513001316 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889513001317 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 889513001318 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889513001319 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889513001320 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 889513001321 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 889513001322 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 889513001323 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889513001324 AIR carboxylase; Region: AIRC; cl00310 889513001325 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 889513001326 putative active site [active] 889513001327 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 889513001328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513001329 dimer interface [polypeptide binding]; other site 889513001330 conserved gate region; other site 889513001331 putative PBP binding loops; other site 889513001332 ABC-ATPase subunit interface; other site 889513001333 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 889513001334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513001335 dimer interface [polypeptide binding]; other site 889513001336 conserved gate region; other site 889513001337 putative PBP binding loops; other site 889513001338 ABC-ATPase subunit interface; other site 889513001339 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 889513001340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889513001341 AMP-binding enzyme; Region: AMP-binding; cl15778 889513001342 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 889513001343 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 889513001344 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 889513001345 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 889513001346 Probable Catalytic site; other site 889513001347 metal-binding site 889513001348 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 889513001349 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 889513001350 active site 889513001351 Substrate binding site; other site 889513001352 Mg++ binding site; other site 889513001353 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 889513001354 putative trimer interface [polypeptide binding]; other site 889513001355 putative CoA binding site [chemical binding]; other site 889513001356 Transcription factor WhiB; Region: Whib; pfam02467 889513001357 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 889513001358 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 889513001359 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 889513001360 active site 889513001361 substrate binding site [chemical binding]; other site 889513001362 metal binding site [ion binding]; metal-binding site 889513001363 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 889513001364 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 889513001365 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 889513001366 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 889513001367 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 889513001368 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 889513001369 oligomerization interface [polypeptide binding]; other site 889513001370 active site 889513001371 NAD+ binding site [chemical binding]; other site 889513001372 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 889513001373 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 889513001374 TMP-binding site; other site 889513001375 ATP-binding site [chemical binding]; other site 889513001376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889513001377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889513001378 active site 889513001379 phosphorylation site [posttranslational modification] 889513001380 intermolecular recognition site; other site 889513001381 dimerization interface [polypeptide binding]; other site 889513001382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889513001383 DNA binding site [nucleotide binding] 889513001384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 889513001385 dimerization interface [polypeptide binding]; other site 889513001386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889513001387 dimer interface [polypeptide binding]; other site 889513001388 phosphorylation site [posttranslational modification] 889513001389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889513001390 ATP binding site [chemical binding]; other site 889513001391 Mg2+ binding site [ion binding]; other site 889513001392 G-X-G motif; other site 889513001393 lipoprotein LpqB; Provisional; Region: PRK13616 889513001394 Sporulation and spore germination; Region: Germane; cl11253 889513001395 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 889513001396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889513001397 active site 889513001398 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 889513001399 30S subunit binding site; other site 889513001400 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 889513001401 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 889513001402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513001403 nucleotide binding region [chemical binding]; other site 889513001404 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889513001405 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 889513001406 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 889513001407 FAD binding pocket [chemical binding]; other site 889513001408 FAD binding motif [chemical binding]; other site 889513001409 phosphate binding motif [ion binding]; other site 889513001410 beta-alpha-beta structure motif; other site 889513001411 NAD binding pocket [chemical binding]; other site 889513001412 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 889513001413 catalytic loop [active] 889513001414 iron binding site [ion binding]; other site 889513001415 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 889513001416 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 889513001417 putative di-iron ligands [ion binding]; other site 889513001418 Predicted GTPases [General function prediction only]; Region: COG1162 889513001419 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 889513001420 GTPase/Zn-binding domain interface [polypeptide binding]; other site 889513001421 GTP/Mg2+ binding site [chemical binding]; other site 889513001422 G4 box; other site 889513001423 G5 box; other site 889513001424 G1 box; other site 889513001425 Switch I region; other site 889513001426 G2 box; other site 889513001427 G3 box; other site 889513001428 Switch II region; other site 889513001429 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 889513001430 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 889513001431 hinge; other site 889513001432 active site 889513001433 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 889513001434 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 889513001435 putative deacylase active site [active] 889513001436 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 889513001437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889513001438 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 889513001439 DNA binding residues [nucleotide binding] 889513001440 Putative zinc-finger; Region: zf-HC2; cl15806 889513001441 Transcription factor WhiB; Region: Whib; pfam02467 889513001442 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 889513001443 active site 889513001444 catalytic triad [active] 889513001445 oxyanion hole [active] 889513001446 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 889513001447 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 889513001448 DEAD-like helicases superfamily; Region: DEXDc; smart00487 889513001449 ATP binding site [chemical binding]; other site 889513001450 Mg++ binding site [ion binding]; other site 889513001451 motif III; other site 889513001452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513001453 nucleotide binding region [chemical binding]; other site 889513001454 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 889513001455 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 889513001456 TIGR02569 family protein; Region: TIGR02569_actnb 889513001457 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 889513001458 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 889513001459 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 889513001460 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 889513001461 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513001462 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 889513001463 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 889513001464 Ion channel; Region: Ion_trans_2; cl11596 889513001465 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 889513001466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513001467 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 889513001468 putative NADH binding site [chemical binding]; other site 889513001469 putative active site [active] 889513001470 nudix motif; other site 889513001471 putative metal binding site [ion binding]; other site 889513001472 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 889513001473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513001474 Family description; Region: UvrD_C_2; cl15862 889513001475 HRDC domain; Region: HRDC; cl02578 889513001476 Protein of unknown function DUF45; Region: DUF45; cl00636 889513001477 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 889513001478 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 889513001479 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 889513001480 protein binding site [polypeptide binding]; other site 889513001481 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 889513001482 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 889513001483 Abi-like protein; Region: Abi_2; cl01988 889513001484 Predicted helicase [General function prediction only]; Region: COG4889 889513001485 Restriction endonuclease; Region: Mrr_cat; cl00516 889513001486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513001487 ATP binding site [chemical binding]; other site 889513001488 putative Mg++ binding site [ion binding]; other site 889513001489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513001490 nucleotide binding region [chemical binding]; other site 889513001491 ATP-binding site [chemical binding]; other site 889513001492 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 889513001493 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 889513001494 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 889513001495 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 889513001496 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 889513001497 Predicted membrane protein [Function unknown]; Region: COG2311 889513001498 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 889513001499 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 889513001500 AMP-binding enzyme; Region: AMP-binding; cl15778 889513001501 Phosphopantetheine attachment site; Region: PP-binding; cl09936 889513001502 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 889513001503 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 889513001504 putative trimer interface [polypeptide binding]; other site 889513001505 putative CoA binding site [chemical binding]; other site 889513001506 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 889513001507 putative trimer interface [polypeptide binding]; other site 889513001508 putative CoA binding site [chemical binding]; other site 889513001509 L-asparagine permease; Provisional; Region: PRK15049 889513001510 oxaloacetate decarboxylase; Provisional; Region: PRK12330 889513001511 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 889513001512 active site 889513001513 catalytic residues [active] 889513001514 metal binding site [ion binding]; metal-binding site 889513001515 homodimer binding site [polypeptide binding]; other site 889513001516 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 889513001517 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889513001518 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889513001519 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889513001520 carboxyltransferase (CT) interaction site; other site 889513001521 biotinylation site [posttranslational modification]; other site 889513001522 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 889513001523 active site 889513001524 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 889513001525 active site 889513001526 peptide chain release factor 2; Validated; Region: prfB; PRK00578 889513001527 RF-1 domain; Region: RF-1; cl02875 889513001528 RF-1 domain; Region: RF-1; cl02875 889513001529 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513001530 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 889513001531 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 889513001532 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 889513001533 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513001534 Walker A/P-loop; other site 889513001535 ATP binding site [chemical binding]; other site 889513001536 Q-loop/lid; other site 889513001537 ABC transporter signature motif; other site 889513001538 Walker B; other site 889513001539 D-loop; other site 889513001540 H-loop/switch region; other site 889513001541 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 889513001542 FtsX-like permease family; Region: FtsX; cl15850 889513001543 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 889513001544 SmpB-tmRNA interface; other site 889513001545 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 889513001546 active site clefts [active] 889513001547 zinc binding site [ion binding]; other site 889513001548 dimer interface [polypeptide binding]; other site 889513001549 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 889513001550 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889513001551 intersubunit interface [polypeptide binding]; other site 889513001552 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513001553 ABC-ATPase subunit interface; other site 889513001554 dimer interface [polypeptide binding]; other site 889513001555 putative PBP binding regions; other site 889513001556 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 889513001557 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513001558 ABC-ATPase subunit interface; other site 889513001559 dimer interface [polypeptide binding]; other site 889513001560 putative PBP binding regions; other site 889513001561 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 889513001562 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889513001563 Walker A/P-loop; other site 889513001564 ATP binding site [chemical binding]; other site 889513001565 Q-loop/lid; other site 889513001566 ABC transporter signature motif; other site 889513001567 Walker B; other site 889513001568 D-loop; other site 889513001569 H-loop/switch region; other site 889513001570 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 889513001571 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 889513001572 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 889513001573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513001574 ATP binding site [chemical binding]; other site 889513001575 putative Mg++ binding site [ion binding]; other site 889513001576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513001577 nucleotide binding region [chemical binding]; other site 889513001578 ATP-binding site [chemical binding]; other site 889513001579 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 889513001580 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 889513001581 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 889513001582 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 889513001583 DNA-binding site [nucleotide binding]; DNA binding site 889513001584 RNA-binding motif; other site 889513001585 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 889513001586 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 889513001587 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 889513001588 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 889513001589 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 889513001590 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 889513001591 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889513001592 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 889513001593 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889513001594 catalytic residue [active] 889513001595 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 889513001596 dimer interface [polypeptide binding]; other site 889513001597 Citrate synthase; Region: Citrate_synt; pfam00285 889513001598 active site 889513001599 citrylCoA binding site [chemical binding]; other site 889513001600 NADH binding [chemical binding]; other site 889513001601 cationic pore residues; other site 889513001602 oxalacetate/citrate binding site [chemical binding]; other site 889513001603 coenzyme A binding site [chemical binding]; other site 889513001604 catalytic triad [active] 889513001605 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 889513001606 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 889513001607 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889513001608 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 889513001609 E-class dimer interface [polypeptide binding]; other site 889513001610 P-class dimer interface [polypeptide binding]; other site 889513001611 active site 889513001612 Cu2+ binding site [ion binding]; other site 889513001613 Zn2+ binding site [ion binding]; other site 889513001614 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889513001615 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889513001616 active site 889513001617 catalytic tetrad [active] 889513001618 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 889513001619 substrate binding site [chemical binding]; other site 889513001620 oxyanion hole (OAH) forming residues; other site 889513001621 trimer interface [polypeptide binding]; other site 889513001622 Protein of unknown function, DUF485; Region: DUF485; cl01231 889513001623 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 889513001624 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 889513001625 Na binding site [ion binding]; other site 889513001626 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 889513001627 active site 889513001628 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889513001629 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 889513001630 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 889513001631 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 889513001632 dimer interface [polypeptide binding]; other site 889513001633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513001634 catalytic residue [active] 889513001635 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 889513001636 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 889513001637 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889513001638 catalytic residue [active] 889513001639 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 889513001640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513001641 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 889513001642 substrate binding pocket [chemical binding]; other site 889513001643 active site 889513001644 iron coordination sites [ion binding]; other site 889513001645 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 889513001646 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 889513001647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513001648 dimer interface [polypeptide binding]; other site 889513001649 conserved gate region; other site 889513001650 putative PBP binding loops; other site 889513001651 ABC-ATPase subunit interface; other site 889513001652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 889513001653 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 889513001654 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513001655 Walker A/P-loop; other site 889513001656 ATP binding site [chemical binding]; other site 889513001657 Q-loop/lid; other site 889513001658 ABC transporter signature motif; other site 889513001659 Walker B; other site 889513001660 D-loop; other site 889513001661 H-loop/switch region; other site 889513001662 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513001663 Walker A/P-loop; other site 889513001664 ATP binding site [chemical binding]; other site 889513001665 Q-loop/lid; other site 889513001666 ABC transporter signature motif; other site 889513001667 Walker B; other site 889513001668 D-loop; other site 889513001669 H-loop/switch region; other site 889513001670 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 889513001671 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 889513001672 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 889513001673 catalytic residues [active] 889513001674 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 889513001675 folate binding site [chemical binding]; other site 889513001676 NADP+ binding site [chemical binding]; other site 889513001677 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 889513001678 dimerization interface [polypeptide binding]; other site 889513001679 active site 889513001680 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 889513001681 active site 889513001682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513001683 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 889513001684 ATP binding site [chemical binding]; other site 889513001685 putative Mg++ binding site [ion binding]; other site 889513001686 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513001687 nucleotide binding region [chemical binding]; other site 889513001688 ATP-binding site [chemical binding]; other site 889513001689 DEAD/H associated; Region: DEAD_assoc; pfam08494 889513001690 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 889513001691 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 889513001692 active site 889513001693 SUMO-1 interface [polypeptide binding]; other site 889513001694 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 889513001695 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 889513001696 putative DNA binding site [nucleotide binding]; other site 889513001697 catalytic residue [active] 889513001698 putative H2TH interface [polypeptide binding]; other site 889513001699 putative catalytic residues [active] 889513001700 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 889513001701 hypothetical protein; Provisional; Region: PRK11770 889513001702 Domain of unknown function (DUF307); Region: DUF307; pfam03733 889513001703 Domain of unknown function (DUF307); Region: DUF307; pfam03733 889513001704 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 889513001705 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 889513001706 active site 889513001707 dimer interface [polypeptide binding]; other site 889513001708 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 889513001709 dimer interface [polypeptide binding]; other site 889513001710 active site 889513001711 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 889513001712 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 889513001713 tetramerization interface [polypeptide binding]; other site 889513001714 NAD(P) binding site [chemical binding]; other site 889513001715 catalytic residues [active] 889513001716 Chorismate mutase type II; Region: CM_2; cl00693 889513001717 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 889513001718 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513001719 Family description; Region: UvrD_C_2; cl15862 889513001720 Peptidase family M23; Region: Peptidase_M23; pfam01551 889513001721 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 889513001722 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 889513001723 active site 889513001724 substrate binding site [chemical binding]; other site 889513001725 cosubstrate binding site; other site 889513001726 catalytic site [active] 889513001727 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 889513001728 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 889513001729 purine monophosphate binding site [chemical binding]; other site 889513001730 dimer interface [polypeptide binding]; other site 889513001731 putative catalytic residues [active] 889513001732 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 889513001733 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 889513001734 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 889513001735 Walker A/P-loop; other site 889513001736 ATP binding site [chemical binding]; other site 889513001737 Q-loop/lid; other site 889513001738 ABC transporter signature motif; other site 889513001739 Walker B; other site 889513001740 D-loop; other site 889513001741 H-loop/switch region; other site 889513001742 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 889513001743 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889513001744 substrate binding pocket [chemical binding]; other site 889513001745 membrane-bound complex binding site; other site 889513001746 hinge residues; other site 889513001747 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 889513001748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513001749 dimer interface [polypeptide binding]; other site 889513001750 conserved gate region; other site 889513001751 putative PBP binding loops; other site 889513001752 ABC-ATPase subunit interface; other site 889513001753 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 889513001754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513001755 dimer interface [polypeptide binding]; other site 889513001756 conserved gate region; other site 889513001757 putative PBP binding loops; other site 889513001758 ABC-ATPase subunit interface; other site 889513001759 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 889513001760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889513001761 Helix-turn-helix domains; Region: HTH; cl00088 889513001762 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 889513001763 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 889513001764 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 889513001765 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 889513001766 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 889513001767 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 889513001768 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 889513001769 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889513001770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889513001771 active site 889513001772 phosphorylation site [posttranslational modification] 889513001773 intermolecular recognition site; other site 889513001774 dimerization interface [polypeptide binding]; other site 889513001775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889513001776 DNA binding site [nucleotide binding] 889513001777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 889513001778 dimerization interface [polypeptide binding]; other site 889513001779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889513001780 dimer interface [polypeptide binding]; other site 889513001781 phosphorylation site [posttranslational modification] 889513001782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889513001783 ATP binding site [chemical binding]; other site 889513001784 Mg2+ binding site [ion binding]; other site 889513001785 G-X-G motif; other site 889513001786 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 889513001787 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 889513001788 protein binding site [polypeptide binding]; other site 889513001789 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 889513001790 MPT binding site; other site 889513001791 trimer interface [polypeptide binding]; other site 889513001792 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 889513001793 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 889513001794 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 889513001795 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 889513001796 active site 889513001797 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 889513001798 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 889513001799 dimer interface [polypeptide binding]; other site 889513001800 putative functional site; other site 889513001801 putative MPT binding site; other site 889513001802 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 889513001803 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513001804 DoxX; Region: DoxX; cl00976 889513001805 Predicted integral membrane protein [Function unknown]; Region: COG5660 889513001806 Putative zinc-finger; Region: zf-HC2; cl15806 889513001807 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 889513001808 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 889513001809 BCCT family transporter; Region: BCCT; cl00569 889513001810 Uncharacterized membrane protein [Function unknown]; Region: COG3949 889513001811 Predicted methyltransferases [General function prediction only]; Region: COG0313 889513001812 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 889513001813 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 889513001814 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 889513001815 active site 889513001816 HIGH motif; other site 889513001817 KMSKS motif; other site 889513001818 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 889513001819 tRNA binding surface [nucleotide binding]; other site 889513001820 anticodon binding site; other site 889513001821 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 889513001822 active site 889513001823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 889513001824 Domain of unknown function (DUF348); Region: DUF348; pfam03990 889513001825 Domain of unknown function (DUF348); Region: DUF348; pfam03990 889513001826 G5 domain; Region: G5; pfam07501 889513001827 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 889513001828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513001829 S-adenosylmethionine binding site [chemical binding]; other site 889513001830 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 889513001831 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 889513001832 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889513001833 ABC transporter; Region: ABC_tran_2; pfam12848 889513001834 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889513001835 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 889513001836 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 889513001837 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 889513001838 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 889513001839 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 889513001840 substrate binding site [chemical binding]; other site 889513001841 oxyanion hole (OAH) forming residues; other site 889513001842 trimer interface [polypeptide binding]; other site 889513001843 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 889513001844 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 889513001845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513001846 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 889513001847 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 889513001848 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 889513001849 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 889513001850 G1 box; other site 889513001851 putative GEF interaction site [polypeptide binding]; other site 889513001852 GTP/Mg2+ binding site [chemical binding]; other site 889513001853 Switch I region; other site 889513001854 G2 box; other site 889513001855 G3 box; other site 889513001856 Switch II region; other site 889513001857 G4 box; other site 889513001858 G5 box; other site 889513001859 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 889513001860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513001861 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 889513001862 NAD(P) binding site [chemical binding]; other site 889513001863 active site 889513001864 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 889513001865 putative active site [active] 889513001866 catalytic residue [active] 889513001867 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 889513001868 FMN binding site [chemical binding]; other site 889513001869 substrate binding site [chemical binding]; other site 889513001870 putative catalytic residue [active] 889513001871 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 889513001872 putative active site [active] 889513001873 catalytic residue [active] 889513001874 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 889513001875 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 889513001876 5S rRNA interface [nucleotide binding]; other site 889513001877 CTC domain interface [polypeptide binding]; other site 889513001878 L16 interface [polypeptide binding]; other site 889513001879 pullulanase, type I; Region: pulA_typeI; TIGR02104 889513001880 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 889513001881 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 889513001882 Ca binding site [ion binding]; other site 889513001883 active site 889513001884 catalytic site [active] 889513001885 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 889513001886 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 889513001887 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889513001888 active site 889513001889 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 889513001890 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 889513001891 Substrate binding site; other site 889513001892 Mg++ binding site; other site 889513001893 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 889513001894 active site 889513001895 substrate binding site [chemical binding]; other site 889513001896 CoA binding site [chemical binding]; other site 889513001897 multicopper oxidase; Provisional; Region: PRK10965 889513001898 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 889513001899 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 889513001900 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 889513001901 gating phenylalanine in ion channel; other site 889513001902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889513001903 Helix-turn-helix domains; Region: HTH; cl00088 889513001904 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 889513001905 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 889513001906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513001907 ATP binding site [chemical binding]; other site 889513001908 putative Mg++ binding site [ion binding]; other site 889513001909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513001910 nucleotide binding region [chemical binding]; other site 889513001911 ATP-binding site [chemical binding]; other site 889513001912 TRCF domain; Region: TRCF; cl04088 889513001913 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 889513001914 Spore germination protein; Region: Spore_permease; cl15802 889513001915 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 889513001916 homodimer interface [polypeptide binding]; other site 889513001917 metal binding site [ion binding]; metal-binding site 889513001918 lytic murein transglycosylase; Region: MltB_2; TIGR02283 889513001919 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 889513001920 N-acetyl-D-glucosamine binding site [chemical binding]; other site 889513001921 enolase; Provisional; Region: eno; PRK00077 889513001922 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 889513001923 dimer interface [polypeptide binding]; other site 889513001924 metal binding site [ion binding]; metal-binding site 889513001925 substrate binding pocket [chemical binding]; other site 889513001926 Septum formation initiator; Region: DivIC; cl11433 889513001927 Protein of unknown function (DUF501); Region: DUF501; cl00652 889513001928 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 889513001929 Helix-turn-helix domain; Region: HTH_18; pfam12833 889513001930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889513001931 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 889513001932 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 889513001933 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 889513001934 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 889513001935 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 889513001936 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 889513001937 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 889513001938 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 889513001939 catalytic residue [active] 889513001940 putative FPP diphosphate binding site; other site 889513001941 putative FPP binding hydrophobic cleft; other site 889513001942 dimer interface [polypeptide binding]; other site 889513001943 putative IPP diphosphate binding site; other site 889513001944 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889513001945 pantothenate kinase; Provisional; Region: PRK05439 889513001946 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 889513001947 ATP-binding site [chemical binding]; other site 889513001948 CoA-binding site [chemical binding]; other site 889513001949 Mg2+-binding site [ion binding]; other site 889513001950 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 889513001951 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 889513001952 dimer interface [polypeptide binding]; other site 889513001953 active site 889513001954 glycine-pyridoxal phosphate binding site [chemical binding]; other site 889513001955 folate binding site [chemical binding]; other site 889513001956 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889513001957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513001958 putative substrate translocation pore; other site 889513001959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889513001960 Helix-turn-helix domains; Region: HTH; cl00088 889513001961 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889513001962 dimerization interface [polypeptide binding]; other site 889513001963 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 889513001964 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 889513001965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889513001966 Coenzyme A binding pocket [chemical binding]; other site 889513001967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513001968 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 889513001969 putative substrate translocation pore; other site 889513001970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513001971 Helix-turn-helix domains; Region: HTH; cl00088 889513001972 fumarate hydratase; Reviewed; Region: fumC; PRK00485 889513001973 Class II fumarases; Region: Fumarase_classII; cd01362 889513001974 active site 889513001975 tetramer interface [polypeptide binding]; other site 889513001976 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 889513001977 putative active site [active] 889513001978 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 889513001979 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 889513001980 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 889513001981 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 889513001982 generic binding surface II; other site 889513001983 generic binding surface I; other site 889513001984 LytB protein; Region: LYTB; cl00507 889513001985 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 889513001986 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 889513001987 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 889513001988 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 889513001989 GTP-binding protein YchF; Reviewed; Region: PRK09601 889513001990 YchF GTPase; Region: YchF; cd01900 889513001991 G1 box; other site 889513001992 GTP/Mg2+ binding site [chemical binding]; other site 889513001993 Switch I region; other site 889513001994 G2 box; other site 889513001995 Switch II region; other site 889513001996 G3 box; other site 889513001997 G4 box; other site 889513001998 G5 box; other site 889513001999 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 889513002000 Protein of unknown function, DUF488; Region: DUF488; cl01246 889513002001 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 889513002002 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 889513002003 PhnA protein; Region: PhnA; pfam03831 889513002004 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889513002005 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889513002006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002007 Walker A/P-loop; other site 889513002008 ATP binding site [chemical binding]; other site 889513002009 Q-loop/lid; other site 889513002010 ABC transporter signature motif; other site 889513002011 Walker B; other site 889513002012 D-loop; other site 889513002013 H-loop/switch region; other site 889513002014 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 889513002015 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889513002016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002017 Walker A/P-loop; other site 889513002018 ATP binding site [chemical binding]; other site 889513002019 Q-loop/lid; other site 889513002020 ABC transporter signature motif; other site 889513002021 Walker B; other site 889513002022 D-loop; other site 889513002023 H-loop/switch region; other site 889513002024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002025 Walker A/P-loop; other site 889513002026 ATP binding site [chemical binding]; other site 889513002027 Q-loop/lid; other site 889513002028 AAA domain; Region: AAA_21; pfam13304 889513002029 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 889513002030 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002031 Q-loop/lid; other site 889513002032 ABC transporter signature motif; other site 889513002033 Walker B; other site 889513002034 D-loop; other site 889513002035 H-loop/switch region; other site 889513002036 Protein of unknown function (DUF808); Region: DUF808; cl01002 889513002037 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 889513002038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513002039 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 889513002040 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 889513002041 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889513002042 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889513002043 Walker A/P-loop; other site 889513002044 ATP binding site [chemical binding]; other site 889513002045 Q-loop/lid; other site 889513002046 ABC transporter signature motif; other site 889513002047 Walker B; other site 889513002048 D-loop; other site 889513002049 H-loop/switch region; other site 889513002050 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889513002051 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 889513002052 Walker A/P-loop; other site 889513002053 ATP binding site [chemical binding]; other site 889513002054 Q-loop/lid; other site 889513002055 ABC transporter signature motif; other site 889513002056 Walker B; other site 889513002057 D-loop; other site 889513002058 H-loop/switch region; other site 889513002059 Cobalt transport protein; Region: CbiQ; cl00463 889513002060 cytidylate kinase; Region: cmk; TIGR00017 889513002061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002062 active site 889513002063 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 889513002064 nudix motif; other site 889513002065 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 889513002066 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 889513002067 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889513002068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513002069 dimer interface [polypeptide binding]; other site 889513002070 conserved gate region; other site 889513002071 ABC-ATPase subunit interface; other site 889513002072 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 889513002073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513002074 dimer interface [polypeptide binding]; other site 889513002075 conserved gate region; other site 889513002076 putative PBP binding loops; other site 889513002077 ABC-ATPase subunit interface; other site 889513002078 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 889513002079 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513002080 Walker A/P-loop; other site 889513002081 ATP binding site [chemical binding]; other site 889513002082 Q-loop/lid; other site 889513002083 ABC transporter signature motif; other site 889513002084 Walker B; other site 889513002085 D-loop; other site 889513002086 H-loop/switch region; other site 889513002087 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889513002088 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513002089 Walker A/P-loop; other site 889513002090 ATP binding site [chemical binding]; other site 889513002091 Q-loop/lid; other site 889513002092 ABC transporter signature motif; other site 889513002093 Walker B; other site 889513002094 D-loop; other site 889513002095 H-loop/switch region; other site 889513002096 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 889513002097 cleavage site 889513002098 active site 889513002099 substrate binding sites [chemical binding]; other site 889513002100 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 889513002101 ArsC family; Region: ArsC; pfam03960 889513002102 catalytic residues [active] 889513002103 Protein of unknown function (DUF402); Region: DUF402; cl00979 889513002104 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002105 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 889513002106 G1 box; other site 889513002107 GTP/Mg2+ binding site [chemical binding]; other site 889513002108 G2 box; other site 889513002109 Switch I region; other site 889513002110 G3 box; other site 889513002111 Switch II region; other site 889513002112 G4 box; other site 889513002113 G5 box; other site 889513002114 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 889513002115 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 889513002116 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 889513002117 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 889513002118 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 889513002119 Ferredoxin [Energy production and conversion]; Region: COG1146 889513002120 4Fe-4S binding domain; Region: Fer4; cl02805 889513002121 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 889513002122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889513002123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513002124 homodimer interface [polypeptide binding]; other site 889513002125 catalytic residue [active] 889513002126 GtrA-like protein; Region: GtrA; cl00971 889513002127 Domain of unknown function (DUF222); Region: DUF222; pfam02720 889513002128 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 889513002129 active site 889513002130 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 889513002131 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 889513002132 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 889513002133 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 889513002134 putative trimer interface [polypeptide binding]; other site 889513002135 putative CoA binding site [chemical binding]; other site 889513002136 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 889513002137 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 889513002138 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 889513002139 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 889513002140 putative trimer interface [polypeptide binding]; other site 889513002141 putative CoA binding site [chemical binding]; other site 889513002142 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 889513002143 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 889513002144 metal binding site [ion binding]; metal-binding site 889513002145 putative dimer interface [polypeptide binding]; other site 889513002146 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 889513002147 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 889513002148 dihydropteroate synthase; Region: DHPS; TIGR01496 889513002149 substrate binding pocket [chemical binding]; other site 889513002150 dimer interface [polypeptide binding]; other site 889513002151 inhibitor binding site; inhibition site 889513002152 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 889513002153 Ligand binding site; other site 889513002154 Putative Catalytic site; other site 889513002155 DXD motif; other site 889513002156 DivIVA domain; Region: DivI1A_domain; TIGR03544 889513002157 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 889513002158 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 889513002159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513002160 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 889513002161 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 889513002162 active site 889513002163 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 889513002164 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 889513002165 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 889513002166 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 889513002167 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 889513002168 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 889513002169 ligand binding site; other site 889513002170 oligomer interface; other site 889513002171 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 889513002172 dimer interface [polypeptide binding]; other site 889513002173 N-terminal domain interface [polypeptide binding]; other site 889513002174 sulfate 1 binding site; other site 889513002175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513002176 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 889513002177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889513002178 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 889513002179 DNA binding residues [nucleotide binding] 889513002180 sec-independent translocase; Provisional; Region: tatB; PRK00182 889513002181 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 889513002182 Domain of unknown function DUF59; Region: DUF59; cl00941 889513002183 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 889513002184 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 889513002185 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 889513002186 MgtE intracellular N domain; Region: MgtE_N; cl15244 889513002187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 889513002188 NMT1-like family; Region: NMT1_2; cl15260 889513002189 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 889513002190 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 889513002191 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 889513002192 TPP-binding site [chemical binding]; other site 889513002193 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 889513002194 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889513002195 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889513002196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002197 Walker A/P-loop; other site 889513002198 ATP binding site [chemical binding]; other site 889513002199 Q-loop/lid; other site 889513002200 ABC transporter signature motif; other site 889513002201 Walker B; other site 889513002202 D-loop; other site 889513002203 H-loop/switch region; other site 889513002204 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889513002205 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889513002206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002207 Walker A/P-loop; other site 889513002208 ATP binding site [chemical binding]; other site 889513002209 Q-loop/lid; other site 889513002210 ABC transporter signature motif; other site 889513002211 Walker B; other site 889513002212 D-loop; other site 889513002213 H-loop/switch region; other site 889513002214 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 889513002215 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 889513002216 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 889513002217 shikimate binding site; other site 889513002218 NAD(P) binding site [chemical binding]; other site 889513002219 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513002220 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 889513002221 substrate binding pocket [chemical binding]; other site 889513002222 catalytic triad [active] 889513002223 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 889513002224 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 889513002225 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 889513002226 active site 889513002227 catalytic residues [active] 889513002228 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 889513002229 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 889513002230 Na binding site [ion binding]; other site 889513002231 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 889513002232 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 889513002233 nucleotide binding site/active site [active] 889513002234 HIT family signature motif; other site 889513002235 catalytic residue [active] 889513002236 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 889513002237 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 889513002238 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 889513002239 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 889513002240 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 889513002241 ATP binding site [chemical binding]; other site 889513002242 Mg++ binding site [ion binding]; other site 889513002243 motif III; other site 889513002244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513002245 nucleotide binding region [chemical binding]; other site 889513002246 ATP-binding site [chemical binding]; other site 889513002247 DbpA RNA binding domain; Region: DbpA; pfam03880 889513002248 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 889513002249 dimer interface [polypeptide binding]; other site 889513002250 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889513002251 Protein of unknown function DUF262; Region: DUF262; cl14890 889513002252 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 889513002253 Na binding site [ion binding]; other site 889513002254 SNF2 Helicase protein; Region: DUF3670; pfam12419 889513002255 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 889513002256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513002257 ATP binding site [chemical binding]; other site 889513002258 putative Mg++ binding site [ion binding]; other site 889513002259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513002260 nucleotide binding region [chemical binding]; other site 889513002261 ATP-binding site [chemical binding]; other site 889513002262 SWIM zinc finger; Region: SWIM; cl15408 889513002263 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 889513002264 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 889513002265 active site 889513002266 metal binding site [ion binding]; metal-binding site 889513002267 DNA binding site [nucleotide binding] 889513002268 AAA domain; Region: AAA_23; pfam13476 889513002269 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 889513002270 AAA domain; Region: AAA_27; pfam13514 889513002271 YceI-like domain; Region: YceI; cl01001 889513002272 Helix-turn-helix domains; Region: HTH; cl00088 889513002273 PspC domain; Region: PspC; cl00864 889513002274 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 889513002275 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 889513002276 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 889513002277 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 889513002278 Cysteine-rich domain; Region: CCG; pfam02754 889513002279 Cysteine-rich domain; Region: CCG; pfam02754 889513002280 glycolate transporter; Provisional; Region: PRK09695 889513002281 L-lactate permease; Region: Lactate_perm; cl00701 889513002282 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 889513002283 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 889513002284 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 889513002285 active site 889513002286 HIGH motif; other site 889513002287 KMSK motif region; other site 889513002288 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 889513002289 tRNA binding surface [nucleotide binding]; other site 889513002290 anticodon binding site; other site 889513002291 diaminopimelate decarboxylase; Region: lysA; TIGR01048 889513002292 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 889513002293 active site 889513002294 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889513002295 substrate binding site [chemical binding]; other site 889513002296 catalytic residues [active] 889513002297 dimer interface [polypeptide binding]; other site 889513002298 homoserine dehydrogenase; Provisional; Region: PRK06349 889513002299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513002300 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 889513002301 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 889513002302 homoserine kinase; Provisional; Region: PRK01212 889513002303 Predicted transcriptional regulator [Transcription]; Region: COG2345 889513002304 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 889513002305 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 889513002306 AMP-binding enzyme; Region: AMP-binding; cl15778 889513002307 transcription termination factor Rho; Provisional; Region: PRK12678 889513002308 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 889513002309 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 889513002310 RNA binding site [nucleotide binding]; other site 889513002311 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 889513002312 multimer interface [polypeptide binding]; other site 889513002313 Walker A motif; other site 889513002314 ATP binding site [chemical binding]; other site 889513002315 Walker B motif; other site 889513002316 peptide chain release factor 1; Validated; Region: prfA; PRK00591 889513002317 RF-1 domain; Region: RF-1; cl02875 889513002318 RF-1 domain; Region: RF-1; cl02875 889513002319 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 889513002320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513002321 S-adenosylmethionine binding site [chemical binding]; other site 889513002322 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 889513002323 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 889513002324 Mg++ binding site [ion binding]; other site 889513002325 putative catalytic motif [active] 889513002326 substrate binding site [chemical binding]; other site 889513002327 ATP synthase A chain; Region: ATP-synt_A; cl00413 889513002328 ATP synthase subunit C; Region: ATP-synt_C; cl00466 889513002329 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 889513002330 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 889513002331 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 889513002332 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 889513002333 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 889513002334 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 889513002335 beta subunit interaction interface [polypeptide binding]; other site 889513002336 Walker A motif; other site 889513002337 ATP binding site [chemical binding]; other site 889513002338 Walker B motif; other site 889513002339 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 889513002340 ATP synthase; Region: ATP-synt; cl00365 889513002341 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 889513002342 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 889513002343 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 889513002344 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 889513002345 alpha subunit interaction interface [polypeptide binding]; other site 889513002346 Walker A motif; other site 889513002347 ATP binding site [chemical binding]; other site 889513002348 Walker B motif; other site 889513002349 inhibitor binding site; inhibition site 889513002350 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 889513002351 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 889513002352 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 889513002353 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 889513002354 Protein of unknown function DUF91; Region: DUF91; cl00709 889513002355 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 889513002356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889513002357 dimer interface [polypeptide binding]; other site 889513002358 substrate binding site [chemical binding]; other site 889513002359 metal binding site [ion binding]; metal-binding site 889513002360 Domain of unknown function DUF77; Region: DUF77; cl00307 889513002361 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 889513002362 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 889513002363 glycogen branching enzyme; Provisional; Region: PRK05402 889513002364 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 889513002365 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 889513002366 active site 889513002367 catalytic site [active] 889513002368 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 889513002369 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 889513002370 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 889513002371 active site 889513002372 catalytic site [active] 889513002373 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889513002374 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889513002375 Walker A/P-loop; other site 889513002376 ATP binding site [chemical binding]; other site 889513002377 ABC transporter signature motif; other site 889513002378 Walker B; other site 889513002379 D-loop; other site 889513002380 H-loop/switch region; other site 889513002381 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 889513002382 Ligand binding site [chemical binding]; other site 889513002383 Electron transfer flavoprotein domain; Region: ETF; pfam01012 889513002384 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 889513002385 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 889513002386 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 889513002387 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889513002388 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 889513002389 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889513002390 catalytic residue [active] 889513002391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513002392 S-adenosylmethionine binding site [chemical binding]; other site 889513002393 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 889513002394 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 889513002395 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 889513002396 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 889513002397 active site 889513002398 catalytic site [active] 889513002399 substrate binding site [chemical binding]; other site 889513002400 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 889513002401 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 889513002402 nucleotide binding pocket [chemical binding]; other site 889513002403 K-X-D-G motif; other site 889513002404 catalytic site [active] 889513002405 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 889513002406 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 889513002407 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 889513002408 Dimer interface [polypeptide binding]; other site 889513002409 BRCT sequence motif; other site 889513002410 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 889513002411 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 889513002412 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 889513002413 Amidase; Region: Amidase; cl11426 889513002414 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513002415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513002416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889513002417 putative substrate translocation pore; other site 889513002418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513002419 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513002420 ABC-ATPase subunit interface; other site 889513002421 dimer interface [polypeptide binding]; other site 889513002422 putative PBP binding regions; other site 889513002423 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889513002424 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889513002425 Walker A/P-loop; other site 889513002426 ATP binding site [chemical binding]; other site 889513002427 Q-loop/lid; other site 889513002428 ABC transporter signature motif; other site 889513002429 Walker B; other site 889513002430 D-loop; other site 889513002431 H-loop/switch region; other site 889513002432 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 889513002433 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 889513002434 putative ligand binding residues [chemical binding]; other site 889513002435 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 889513002436 active site 889513002437 ADP/pyrophosphate binding site [chemical binding]; other site 889513002438 dimerization interface [polypeptide binding]; other site 889513002439 allosteric effector site; other site 889513002440 fructose-1,6-bisphosphate binding site; other site 889513002441 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 889513002442 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 889513002443 GatB domain; Region: GatB_Yqey; cl11497 889513002444 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 889513002445 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889513002446 active site 889513002447 catalytic tetrad [active] 889513002448 LysE type translocator; Region: LysE; cl00565 889513002449 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 889513002450 Helix-turn-helix domains; Region: HTH; cl00088 889513002451 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889513002452 dimerization interface [polypeptide binding]; other site 889513002453 Protein of unknown function DUF262; Region: DUF262; cl14890 889513002454 ribonuclease E; Reviewed; Region: rne; PRK10811 889513002455 DoxX; Region: DoxX; cl00976 889513002456 Dehydratase family; Region: ILVD_EDD; cl00340 889513002457 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 889513002458 Mechanosensitive ion channel; Region: MS_channel; pfam00924 889513002459 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 889513002460 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 889513002461 putative valine binding site [chemical binding]; other site 889513002462 dimer interface [polypeptide binding]; other site 889513002463 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 889513002464 ketol-acid reductoisomerase; Provisional; Region: PRK05479 889513002465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513002466 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 889513002467 Cation efflux family; Region: Cation_efflux; cl00316 889513002468 Protein of unknown function DUF262; Region: DUF262; cl14890 889513002469 Protein of unknown function DUF262; Region: DUF262; cl14890 889513002470 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 889513002471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513002472 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 889513002473 putative L-serine binding site [chemical binding]; other site 889513002474 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 889513002475 tartrate dehydrogenase; Provisional; Region: PRK08194 889513002476 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 889513002477 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 889513002478 ligand binding site [chemical binding]; other site 889513002479 flexible hinge region; other site 889513002480 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 889513002481 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 889513002482 metal binding triad; other site 889513002483 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 889513002484 active site 889513002485 catalytic site [active] 889513002486 substrate binding site [chemical binding]; other site 889513002487 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 889513002488 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 889513002489 chorismate binding enzyme; Region: Chorismate_bind; cl10555 889513002490 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 889513002491 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889513002492 HIGH motif; other site 889513002493 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 889513002494 active site 889513002495 KMSKS motif; other site 889513002496 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 889513002497 biotin synthase; Region: bioB; TIGR00433 889513002498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889513002499 FeS/SAM binding site; other site 889513002500 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 889513002501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 889513002502 Transcriptional regulator [Transcription]; Region: IclR; COG1414 889513002503 Helix-turn-helix domains; Region: HTH; cl00088 889513002504 Bacterial transcriptional regulator; Region: IclR; pfam01614 889513002505 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 889513002506 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 889513002507 substrate binding site [chemical binding]; other site 889513002508 ligand binding site [chemical binding]; other site 889513002509 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 889513002510 substrate binding site [chemical binding]; other site 889513002511 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 889513002512 active site 889513002513 Ap6A binding site [chemical binding]; other site 889513002514 nudix motif; other site 889513002515 metal binding site [ion binding]; metal-binding site 889513002516 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889513002517 catalytic core [active] 889513002518 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 889513002519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513002520 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 889513002521 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 889513002522 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 889513002523 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889513002524 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 889513002525 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 889513002526 thiamine monophosphate kinase; Provisional; Region: PRK05731 889513002527 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 889513002528 ATP binding site [chemical binding]; other site 889513002529 dimerization interface [polypeptide binding]; other site 889513002530 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 889513002531 ligand binding site [chemical binding]; other site 889513002532 active site 889513002533 UGI interface [polypeptide binding]; other site 889513002534 catalytic site [active] 889513002535 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 889513002536 DAK2 domain; Region: Dak2; cl03685 889513002537 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 889513002538 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 889513002539 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 889513002540 generic binding surface II; other site 889513002541 ssDNA binding site; other site 889513002542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513002543 ATP binding site [chemical binding]; other site 889513002544 putative Mg++ binding site [ion binding]; other site 889513002545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513002546 nucleotide binding region [chemical binding]; other site 889513002547 ATP-binding site [chemical binding]; other site 889513002548 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889513002549 carboxyltransferase (CT) interaction site; other site 889513002550 biotinylation site [posttranslational modification]; other site 889513002551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513002552 S-adenosylmethionine binding site [chemical binding]; other site 889513002553 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 889513002554 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 889513002555 active site 889513002556 (T/H)XGH motif; other site 889513002557 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 889513002558 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 889513002559 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 889513002560 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 889513002561 Walker A/P-loop; other site 889513002562 ATP binding site [chemical binding]; other site 889513002563 Q-loop/lid; other site 889513002564 ABC transporter signature motif; other site 889513002565 Walker B; other site 889513002566 D-loop; other site 889513002567 H-loop/switch region; other site 889513002568 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 889513002569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513002570 dimer interface [polypeptide binding]; other site 889513002571 conserved gate region; other site 889513002572 putative PBP binding loops; other site 889513002573 ABC-ATPase subunit interface; other site 889513002574 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889513002575 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 889513002576 substrate binding pocket [chemical binding]; other site 889513002577 membrane-bound complex binding site; other site 889513002578 hinge residues; other site 889513002579 Domain of unknown function (DUF368); Region: DUF368; cl00893 889513002580 DNA polymerase I; Provisional; Region: PRK05755 889513002581 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 889513002582 active site 889513002583 metal binding site 1 [ion binding]; metal-binding site 889513002584 putative 5' ssDNA interaction site; other site 889513002585 metal binding site 3; metal-binding site 889513002586 metal binding site 2 [ion binding]; metal-binding site 889513002587 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 889513002588 putative DNA binding site [nucleotide binding]; other site 889513002589 putative metal binding site [ion binding]; other site 889513002590 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 889513002591 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 889513002592 active site 889513002593 DNA binding site [nucleotide binding] 889513002594 catalytic site [active] 889513002595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513002596 S-adenosylmethionine binding site [chemical binding]; other site 889513002597 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 889513002598 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 889513002599 RNA binding site [nucleotide binding]; other site 889513002600 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 889513002601 RNA binding site [nucleotide binding]; other site 889513002602 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 889513002603 RNA binding site [nucleotide binding]; other site 889513002604 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 889513002605 RNA binding site [nucleotide binding]; other site 889513002606 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 889513002607 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889513002608 active site turn [active] 889513002609 phosphorylation site [posttranslational modification] 889513002610 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889513002611 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889513002612 HPr interaction site; other site 889513002613 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889513002614 active site 889513002615 phosphorylation site [posttranslational modification] 889513002616 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 889513002617 ATP-binding [chemical binding]; other site 889513002618 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 889513002619 CoA-binding site [chemical binding]; other site 889513002620 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 889513002621 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889513002622 FeS/SAM binding site; other site 889513002623 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 889513002624 excinuclease ABC subunit B; Provisional; Region: PRK05298 889513002625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513002626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513002627 nucleotide binding region [chemical binding]; other site 889513002628 ATP-binding site [chemical binding]; other site 889513002629 Ultra-violet resistance protein B; Region: UvrB; pfam12344 889513002630 UvrB/uvrC motif; Region: UVR; pfam02151 889513002631 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889513002632 Ligand Binding Site [chemical binding]; other site 889513002633 DoxX; Region: DoxX; cl00976 889513002634 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889513002635 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 889513002636 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 889513002637 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 889513002638 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 889513002639 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 889513002640 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 889513002641 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 889513002642 ribosomal protein L20; Region: rpl20; CHL00068 889513002643 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 889513002644 23S rRNA binding site [nucleotide binding]; other site 889513002645 L21 binding site [polypeptide binding]; other site 889513002646 L13 binding site [polypeptide binding]; other site 889513002647 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 889513002648 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 889513002649 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 889513002650 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 889513002651 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 889513002652 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 889513002653 dimer interface [polypeptide binding]; other site 889513002654 motif 1; other site 889513002655 active site 889513002656 motif 2; other site 889513002657 motif 3; other site 889513002658 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 889513002659 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 889513002660 putative tRNA-binding site [nucleotide binding]; other site 889513002661 B3/4 domain; Region: B3_4; cl11458 889513002662 tRNA synthetase B5 domain; Region: B5; cl08394 889513002663 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 889513002664 dimer interface [polypeptide binding]; other site 889513002665 motif 1; other site 889513002666 motif 3; other site 889513002667 motif 2; other site 889513002668 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 889513002669 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 889513002670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513002671 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 889513002672 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 889513002673 feedback inhibition sensing region; other site 889513002674 homohexameric interface [polypeptide binding]; other site 889513002675 nucleotide binding site [chemical binding]; other site 889513002676 N-acetyl-L-glutamate binding site [chemical binding]; other site 889513002677 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 889513002678 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889513002679 inhibitor-cofactor binding pocket; inhibition site 889513002680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513002681 catalytic residue [active] 889513002682 ornithine carbamoyltransferase; Provisional; Region: PRK00779 889513002683 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 889513002684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513002685 arginine repressor; Provisional; Region: PRK03341 889513002686 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 889513002687 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 889513002688 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 889513002689 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 889513002690 ANP binding site [chemical binding]; other site 889513002691 Substrate Binding Site II [chemical binding]; other site 889513002692 Substrate Binding Site I [chemical binding]; other site 889513002693 argininosuccinate lyase; Provisional; Region: PRK00855 889513002694 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 889513002695 active sites [active] 889513002696 tetramer interface [polypeptide binding]; other site 889513002697 Trm112p-like protein; Region: Trm112p; cl01066 889513002698 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 889513002699 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 889513002700 active site 889513002701 HIGH motif; other site 889513002702 dimer interface [polypeptide binding]; other site 889513002703 KMSKS motif; other site 889513002704 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 889513002705 transcription termination factor Rho; Provisional; Region: PRK12678 889513002706 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 889513002707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889513002708 active site 889513002709 motif I; other site 889513002710 motif II; other site 889513002711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889513002712 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 889513002713 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889513002714 RNA binding surface [nucleotide binding]; other site 889513002715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513002716 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 889513002717 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 889513002718 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 889513002719 Walker A/P-loop; other site 889513002720 ATP binding site [chemical binding]; other site 889513002721 Q-loop/lid; other site 889513002722 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 889513002723 ABC transporter signature motif; other site 889513002724 Walker B; other site 889513002725 D-loop; other site 889513002726 H-loop/switch region; other site 889513002727 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 889513002728 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 889513002729 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 889513002730 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 889513002731 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 889513002732 dimer interface [polypeptide binding]; other site 889513002733 ADP-ribose binding site [chemical binding]; other site 889513002734 active site 889513002735 nudix motif; other site 889513002736 metal binding site [ion binding]; metal-binding site 889513002737 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 889513002738 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 889513002739 active site 889513002740 Int/Topo IB signature motif; other site 889513002741 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 889513002742 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 889513002743 P-loop; other site 889513002744 Magnesium ion binding site [ion binding]; other site 889513002745 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 889513002746 Magnesium ion binding site [ion binding]; other site 889513002747 ScpA/B protein; Region: ScpA_ScpB; cl00598 889513002748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002749 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 889513002750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 889513002751 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889513002752 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 889513002753 inhibitor-cofactor binding pocket; inhibition site 889513002754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513002755 catalytic residue [active] 889513002756 AAA domain; Region: AAA_26; pfam13500 889513002757 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002758 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002759 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 889513002760 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 889513002761 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889513002762 RNA binding surface [nucleotide binding]; other site 889513002763 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 889513002764 active site 889513002765 cytidylate kinase; Provisional; Region: cmk; PRK00023 889513002766 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 889513002767 CMP-binding site; other site 889513002768 The sites determining sugar specificity; other site 889513002769 GTP-binding protein Der; Reviewed; Region: PRK03003 889513002770 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 889513002771 G1 box; other site 889513002772 GTP/Mg2+ binding site [chemical binding]; other site 889513002773 Switch I region; other site 889513002774 G2 box; other site 889513002775 Switch II region; other site 889513002776 G3 box; other site 889513002777 G4 box; other site 889513002778 G5 box; other site 889513002779 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 889513002780 G1 box; other site 889513002781 GTP/Mg2+ binding site [chemical binding]; other site 889513002782 Switch I region; other site 889513002783 G2 box; other site 889513002784 G3 box; other site 889513002785 Switch II region; other site 889513002786 G4 box; other site 889513002787 G5 box; other site 889513002788 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 889513002789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513002790 S-adenosylmethionine binding site [chemical binding]; other site 889513002791 Predicted esterase [General function prediction only]; Region: COG0627 889513002792 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513002793 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 889513002794 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 889513002795 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 889513002796 siderophore binding site; other site 889513002797 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513002798 dimer interface [polypeptide binding]; other site 889513002799 ABC-ATPase subunit interface; other site 889513002800 putative PBP binding regions; other site 889513002801 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513002802 ABC-ATPase subunit interface; other site 889513002803 dimer interface [polypeptide binding]; other site 889513002804 putative PBP binding regions; other site 889513002805 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889513002806 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889513002807 Walker A/P-loop; other site 889513002808 ATP binding site [chemical binding]; other site 889513002809 Q-loop/lid; other site 889513002810 ABC transporter signature motif; other site 889513002811 Walker B; other site 889513002812 D-loop; other site 889513002813 H-loop/switch region; other site 889513002814 IucA / IucC family; Region: IucA_IucC; pfam04183 889513002815 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 889513002816 IucA / IucC family; Region: IucA_IucC; pfam04183 889513002817 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 889513002818 H+ Antiporter protein; Region: 2A0121; TIGR00900 889513002819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 889513002820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 889513002821 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 889513002822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002823 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 889513002824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513002825 nucleotide binding region [chemical binding]; other site 889513002826 ATP-binding site [chemical binding]; other site 889513002827 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 889513002828 phosphopeptide binding site; other site 889513002829 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 889513002830 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 889513002831 DNA binding residues [nucleotide binding] 889513002832 Bifunctional nuclease; Region: DNase-RNase; cl00553 889513002833 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 889513002834 DNA binding residues [nucleotide binding] 889513002835 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 889513002836 putative dimer interface [polypeptide binding]; other site 889513002837 Domain of unknown function DUF21; Region: DUF21; pfam01595 889513002838 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 889513002839 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 889513002840 Domain of unknown function DUF21; Region: DUF21; pfam01595 889513002841 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 889513002842 Transporter associated domain; Region: CorC_HlyC; cl08393 889513002843 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 889513002844 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 889513002845 ATP binding site [chemical binding]; other site 889513002846 Mg++ binding site [ion binding]; other site 889513002847 motif III; other site 889513002848 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513002849 nucleotide binding region [chemical binding]; other site 889513002850 ATP-binding site [chemical binding]; other site 889513002851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513002852 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 889513002853 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 889513002854 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 889513002855 CoenzymeA binding site [chemical binding]; other site 889513002856 subunit interaction site [polypeptide binding]; other site 889513002857 PHB binding site; other site 889513002858 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 889513002859 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 889513002860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513002861 S-adenosylmethionine binding site [chemical binding]; other site 889513002862 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 889513002863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513002864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889513002865 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 889513002866 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 889513002867 metabolite-proton symporter; Region: 2A0106; TIGR00883 889513002868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513002869 putative substrate translocation pore; other site 889513002870 YceI-like domain; Region: YceI; cl01001 889513002871 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 889513002872 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 889513002873 Ligand binding site; other site 889513002874 Putative Catalytic site; other site 889513002875 DXD motif; other site 889513002876 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 889513002877 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 889513002878 putative active site [active] 889513002879 catalytic triad [active] 889513002880 putative dimer interface [polypeptide binding]; other site 889513002881 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 889513002882 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 889513002883 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 889513002884 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 889513002885 precorrin-3B synthase; Region: CobG; TIGR02435 889513002886 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 889513002887 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 889513002888 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 889513002889 Precorrin-8X methylmutase; Region: CbiC; pfam02570 889513002890 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 889513002891 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 889513002892 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 889513002893 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 889513002894 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 889513002895 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 889513002896 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 889513002897 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 889513002898 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 889513002899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513002900 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 889513002901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513002902 NAD(P) binding site [chemical binding]; other site 889513002903 active site 889513002904 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 889513002905 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 889513002906 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 889513002907 active site 889513002908 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 889513002909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513002910 ATP binding site [chemical binding]; other site 889513002911 putative Mg++ binding site [ion binding]; other site 889513002912 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513002913 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 889513002914 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 889513002915 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 889513002916 Predicted transcriptional regulator [Transcription]; Region: COG2378 889513002917 WYL domain; Region: WYL; cl14852 889513002918 Predicted transcriptional regulator [Transcription]; Region: COG2378 889513002919 WYL domain; Region: WYL; cl14852 889513002920 Pup-ligase protein; Region: Pup_ligase; cl15463 889513002921 Pup-like protein; Region: Pup; cl05289 889513002922 Pup-ligase protein; Region: Pup_ligase; cl15463 889513002923 proteasome ATPase; Region: pup_AAA; TIGR03689 889513002924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513002925 Walker A motif; other site 889513002926 ATP binding site [chemical binding]; other site 889513002927 Walker B motif; other site 889513002928 arginine finger; other site 889513002929 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 889513002930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513002931 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 889513002932 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 889513002933 active site 889513002934 metal binding site [ion binding]; metal-binding site 889513002935 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 889513002936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889513002937 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 889513002938 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 889513002939 Potassium binding sites [ion binding]; other site 889513002940 Cesium cation binding sites [ion binding]; other site 889513002941 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 889513002942 Aspartase; Region: Aspartase; cd01357 889513002943 active sites [active] 889513002944 tetramer interface [polypeptide binding]; other site 889513002945 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 889513002946 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 889513002947 ATP phosphoribosyltransferase; Region: HisG; cl15266 889513002948 HisG, C-terminal domain; Region: HisG_C; cl06867 889513002949 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 889513002950 homodimer interface [polypeptide binding]; other site 889513002951 putative metal binding site [ion binding]; other site 889513002952 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 889513002953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889513002954 motif II; other site 889513002955 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 889513002956 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 889513002957 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 889513002958 substrate binding pocket [chemical binding]; other site 889513002959 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 889513002960 B12 binding site [chemical binding]; other site 889513002961 cobalt ligand [ion binding]; other site 889513002962 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 889513002963 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 889513002964 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889513002965 active site 889513002966 HIGH motif; other site 889513002967 nucleotide binding site [chemical binding]; other site 889513002968 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889513002969 active site 889513002970 KMSKS motif; other site 889513002971 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 889513002972 tRNA binding surface [nucleotide binding]; other site 889513002973 anticodon binding site; other site 889513002974 Bacitracin resistance protein BacA; Region: BacA; cl00858 889513002975 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 889513002976 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889513002977 active site 889513002978 catalytic tetrad [active] 889513002979 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 889513002980 quinone interaction residues [chemical binding]; other site 889513002981 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 889513002982 active site 889513002983 catalytic residues [active] 889513002984 FMN binding site [chemical binding]; other site 889513002985 substrate binding site [chemical binding]; other site 889513002986 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 889513002987 substrate binding site [chemical binding]; other site 889513002988 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 889513002989 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 889513002990 dimerization domain swap beta strand [polypeptide binding]; other site 889513002991 regulatory protein interface [polypeptide binding]; other site 889513002992 active site 889513002993 regulatory phosphorylation site [posttranslational modification]; other site 889513002994 DAK2 domain; Region: Dak2; cl03685 889513002995 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 889513002996 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 889513002997 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889513002998 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 889513002999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513003000 NAD(P) binding site [chemical binding]; other site 889513003001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513003002 NAD(P) binding site [chemical binding]; other site 889513003003 active site 889513003004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003005 GTP/Mg2+ binding site [chemical binding]; other site 889513003006 G4 box; other site 889513003007 membrane ATPase/protein kinase; Provisional; Region: PRK09435 889513003008 G5 box; other site 889513003009 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 889513003010 Walker A; other site 889513003011 G1 box; other site 889513003012 Switch I region; other site 889513003013 G2 box; other site 889513003014 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 889513003015 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 889513003016 active site 889513003017 substrate binding site [chemical binding]; other site 889513003018 coenzyme B12 binding site [chemical binding]; other site 889513003019 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 889513003020 B12 binding site [chemical binding]; other site 889513003021 cobalt ligand [ion binding]; other site 889513003022 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 889513003023 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 889513003024 heterodimer interface [polypeptide binding]; other site 889513003025 substrate interaction site [chemical binding]; other site 889513003026 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 889513003027 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 889513003028 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 889513003029 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 889513003030 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 889513003031 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 889513003032 ferrochelatase; Reviewed; Region: hemH; PRK00035 889513003033 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 889513003034 C-terminal domain interface [polypeptide binding]; other site 889513003035 active site 889513003036 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 889513003037 active site 889513003038 N-terminal domain interface [polypeptide binding]; other site 889513003039 chromosome segregation protein; Provisional; Region: PRK02224 889513003040 NlpC/P60 family; Region: NLPC_P60; cl11438 889513003041 pyruvate carboxylase subunit A; Validated; Region: PRK07178 889513003042 aconitate hydratase; Validated; Region: PRK09277 889513003043 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 889513003044 substrate binding site [chemical binding]; other site 889513003045 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 889513003046 ligand binding site [chemical binding]; other site 889513003047 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 889513003048 substrate binding site [chemical binding]; other site 889513003049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889513003050 Helix-turn-helix domains; Region: HTH; cl00088 889513003051 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 889513003052 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128 889513003053 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 889513003054 catalytic triad [active] 889513003055 conserved cys residue [active] 889513003056 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 889513003057 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 889513003058 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003059 AAA domain; Region: AAA_22; pfam13401 889513003060 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 889513003061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003062 Walker A/P-loop; other site 889513003063 ATP binding site [chemical binding]; other site 889513003064 ABC transporter signature motif; other site 889513003065 Walker B; other site 889513003066 D-loop; other site 889513003067 H-loop/switch region; other site 889513003068 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889513003069 Domain of unknown function DUF59; Region: DUF59; cl00941 889513003070 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 889513003071 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 889513003072 trimerization site [polypeptide binding]; other site 889513003073 active site 889513003074 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 889513003075 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 889513003076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889513003077 catalytic residue [active] 889513003078 FeS assembly ATPase SufC; Region: sufC; TIGR01978 889513003079 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 889513003080 Walker A/P-loop; other site 889513003081 ATP binding site [chemical binding]; other site 889513003082 Q-loop/lid; other site 889513003083 ABC transporter signature motif; other site 889513003084 Walker B; other site 889513003085 D-loop; other site 889513003086 H-loop/switch region; other site 889513003087 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 889513003088 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 889513003089 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 889513003090 FeS assembly protein SufB; Region: sufB; TIGR01980 889513003091 Predicted transcriptional regulator [Transcription]; Region: COG2345 889513003092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889513003093 putative DNA binding site [nucleotide binding]; other site 889513003094 putative Zn2+ binding site [ion binding]; other site 889513003095 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 889513003096 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889513003097 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889513003098 Walker A/P-loop; other site 889513003099 ATP binding site [chemical binding]; other site 889513003100 Q-loop/lid; other site 889513003101 ABC transporter signature motif; other site 889513003102 Walker B; other site 889513003103 D-loop; other site 889513003104 H-loop/switch region; other site 889513003105 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889513003106 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 889513003107 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 889513003108 UbiA prenyltransferase family; Region: UbiA; cl00337 889513003109 transketolase; Reviewed; Region: PRK05899 889513003110 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 889513003111 TPP-binding site [chemical binding]; other site 889513003112 dimer interface [polypeptide binding]; other site 889513003113 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 889513003114 PYR/PP interface [polypeptide binding]; other site 889513003115 dimer interface [polypeptide binding]; other site 889513003116 TPP binding site [chemical binding]; other site 889513003117 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 889513003118 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 889513003119 putative active site [active] 889513003120 transaldolase; Provisional; Region: PRK03903 889513003121 catalytic residue [active] 889513003122 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 889513003123 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 889513003124 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 889513003125 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 889513003126 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 889513003127 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 889513003128 putative active site [active] 889513003129 Preprotein translocase SecG subunit; Region: SecG; cl09123 889513003130 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 889513003131 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 889513003132 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 889513003133 substrate binding site [chemical binding]; other site 889513003134 dimer interface [polypeptide binding]; other site 889513003135 catalytic triad [active] 889513003136 Phosphoglycerate kinase; Region: PGK; pfam00162 889513003137 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 889513003138 substrate binding site [chemical binding]; other site 889513003139 hinge regions; other site 889513003140 ADP binding site [chemical binding]; other site 889513003141 catalytic site [active] 889513003142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513003143 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 889513003144 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 889513003145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 889513003146 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 889513003147 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 889513003148 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 889513003149 phosphate binding site [ion binding]; other site 889513003150 putative substrate binding pocket [chemical binding]; other site 889513003151 dimer interface [polypeptide binding]; other site 889513003152 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 889513003153 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 889513003154 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 889513003155 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 889513003156 GIY-YIG motif/motif A; other site 889513003157 active site 889513003158 catalytic site [active] 889513003159 putative DNA binding site [nucleotide binding]; other site 889513003160 metal binding site [ion binding]; metal-binding site 889513003161 UvrB/uvrC motif; Region: UVR; pfam02151 889513003162 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 889513003163 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 889513003164 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 889513003165 homopentamer interface [polypeptide binding]; other site 889513003166 active site 889513003167 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 889513003168 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 889513003169 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 889513003170 dimerization interface [polypeptide binding]; other site 889513003171 active site 889513003172 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 889513003173 Lumazine binding domain; Region: Lum_binding; pfam00677 889513003174 Lumazine binding domain; Region: Lum_binding; pfam00677 889513003175 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 889513003176 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 889513003177 catalytic motif [active] 889513003178 Zn binding site [ion binding]; other site 889513003179 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 889513003180 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 889513003181 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 889513003182 substrate binding site [chemical binding]; other site 889513003183 hexamer interface [polypeptide binding]; other site 889513003184 metal binding site [ion binding]; metal-binding site 889513003185 16S rRNA methyltransferase B; Provisional; Region: PRK14902 889513003186 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 889513003187 putative RNA binding site [nucleotide binding]; other site 889513003188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513003189 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 889513003190 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 889513003191 putative active site [active] 889513003192 substrate binding site [chemical binding]; other site 889513003193 putative cosubstrate binding site; other site 889513003194 catalytic site [active] 889513003195 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 889513003196 substrate binding site [chemical binding]; other site 889513003197 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 889513003198 active site 889513003199 catalytic residues [active] 889513003200 metal binding site [ion binding]; metal-binding site 889513003201 primosome assembly protein PriA; Provisional; Region: PRK14873 889513003202 S-adenosylmethionine synthetase; Validated; Region: PRK05250 889513003203 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 889513003204 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 889513003205 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 889513003206 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 889513003207 Flavoprotein; Region: Flavoprotein; cl08021 889513003208 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 889513003209 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 889513003210 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 889513003211 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 889513003212 catalytic site [active] 889513003213 G-X2-G-X-G-K; other site 889513003214 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 889513003215 active site 889513003216 dimer interface [polypeptide binding]; other site 889513003217 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 889513003218 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889513003219 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889513003220 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 889513003221 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889513003222 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889513003223 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 889513003224 IMP binding site; other site 889513003225 dimer interface [polypeptide binding]; other site 889513003226 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 889513003227 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 889513003228 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 889513003229 catalytic site [active] 889513003230 subunit interface [polypeptide binding]; other site 889513003231 dihydroorotase; Validated; Region: pyrC; PRK09357 889513003232 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 889513003233 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 889513003234 active site 889513003235 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 889513003236 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 889513003237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513003238 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889513003239 active site 889513003240 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 889513003241 putative hydrophobic ligand binding site [chemical binding]; other site 889513003242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513003243 TIGR01777 family protein; Region: yfcH 889513003244 NAD(P) binding site [chemical binding]; other site 889513003245 active site 889513003246 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 889513003247 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 889513003248 putative RNA binding site [nucleotide binding]; other site 889513003249 elongation factor P; Validated; Region: PRK00529 889513003250 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 889513003251 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 889513003252 RNA binding site [nucleotide binding]; other site 889513003253 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 889513003254 RNA binding site [nucleotide binding]; other site 889513003255 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 889513003256 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 889513003257 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 889513003258 active site 889513003259 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 889513003260 trimer interface [polypeptide binding]; other site 889513003261 active site 889513003262 dimer interface [polypeptide binding]; other site 889513003263 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 889513003264 active site 889513003265 dimer interface [polypeptide binding]; other site 889513003266 metal binding site [ion binding]; metal-binding site 889513003267 shikimate kinase; Reviewed; Region: aroK; PRK00131 889513003268 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 889513003269 ADP binding site [chemical binding]; other site 889513003270 magnesium binding site [ion binding]; other site 889513003271 putative shikimate binding site; other site 889513003272 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 889513003273 Tetramer interface [polypeptide binding]; other site 889513003274 active site 889513003275 FMN-binding site [chemical binding]; other site 889513003276 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 889513003277 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 889513003278 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 889513003279 shikimate binding site; other site 889513003280 NAD(P) binding site [chemical binding]; other site 889513003281 YceG-like family; Region: YceG; pfam02618 889513003282 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 889513003283 dimerization interface [polypeptide binding]; other site 889513003284 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 889513003285 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 889513003286 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 889513003287 motif 1; other site 889513003288 active site 889513003289 motif 2; other site 889513003290 motif 3; other site 889513003291 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 889513003292 DHHA1 domain; Region: DHHA1; pfam02272 889513003293 recombination factor protein RarA; Reviewed; Region: PRK13342 889513003294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513003295 Walker A motif; other site 889513003296 ATP binding site [chemical binding]; other site 889513003297 Walker B motif; other site 889513003298 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 889513003299 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 889513003300 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 889513003301 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 889513003302 dimer interface [polypeptide binding]; other site 889513003303 anticodon binding site; other site 889513003304 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 889513003305 homodimer interface [polypeptide binding]; other site 889513003306 motif 1; other site 889513003307 active site 889513003308 motif 2; other site 889513003309 GAD domain; Region: GAD; pfam02938 889513003310 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 889513003311 active site 889513003312 motif 3; other site 889513003313 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 889513003314 DEAD-like helicases superfamily; Region: DEXDc; smart00487 889513003315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513003316 ATP binding site [chemical binding]; other site 889513003317 putative Mg++ binding site [ion binding]; other site 889513003318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513003319 nucleotide binding region [chemical binding]; other site 889513003320 ATP-binding site [chemical binding]; other site 889513003321 Predicted membrane protein [Function unknown]; Region: COG1511 889513003322 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 889513003323 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 889513003324 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 889513003325 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889513003326 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003327 ATP binding site [chemical binding]; other site 889513003328 Q-loop/lid; other site 889513003329 ABC transporter signature motif; other site 889513003330 Walker B; other site 889513003331 D-loop; other site 889513003332 H-loop/switch region; other site 889513003333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889513003334 Helix-turn-helix domains; Region: HTH; cl00088 889513003335 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889513003336 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 889513003337 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 889513003338 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 889513003339 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 889513003340 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 889513003341 putative active site [active] 889513003342 putative catalytic site [active] 889513003343 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 889513003344 CoA-transferase family III; Region: CoA_transf_3; pfam02515 889513003345 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 889513003346 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 889513003347 dimer interface [polypeptide binding]; other site 889513003348 motif 1; other site 889513003349 active site 889513003350 motif 2; other site 889513003351 motif 3; other site 889513003352 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 889513003353 anticodon binding site; other site 889513003354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889513003355 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 889513003356 dimer interface [polypeptide binding]; other site 889513003357 catalytic triad [active] 889513003358 peroxidatic and resolving cysteines [active] 889513003359 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 889513003360 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 889513003361 active site 889513003362 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 889513003363 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889513003364 Zn2+ binding site [ion binding]; other site 889513003365 Mg2+ binding site [ion binding]; other site 889513003366 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 889513003367 synthetase active site [active] 889513003368 NTP binding site [chemical binding]; other site 889513003369 metal binding site [ion binding]; metal-binding site 889513003370 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 889513003371 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 889513003372 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889513003373 active site 889513003374 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 889513003375 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 889513003376 Protein export membrane protein; Region: SecD_SecF; cl14618 889513003377 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 889513003378 Protein export membrane protein; Region: SecD_SecF; cl14618 889513003379 Preprotein translocase subunit; Region: YajC; cl00806 889513003380 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 889513003381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513003382 Walker A motif; other site 889513003383 ATP binding site [chemical binding]; other site 889513003384 Walker B motif; other site 889513003385 arginine finger; other site 889513003386 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 889513003387 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 889513003388 RuvA N terminal domain; Region: RuvA_N; pfam01330 889513003389 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 889513003390 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 889513003391 active site 889513003392 putative DNA-binding cleft [nucleotide binding]; other site 889513003393 dimer interface [polypeptide binding]; other site 889513003394 Transcriptional regulator; Region: Transcrip_reg; cl00361 889513003395 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 889513003396 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 889513003397 active site 889513003398 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 889513003399 catalytic triad [active] 889513003400 dimer interface [polypeptide binding]; other site 889513003401 Protein of unknown function (DUF998); Region: DUF998; pfam06197 889513003402 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 889513003403 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 889513003404 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889513003405 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 889513003406 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889513003407 catalytic residue [active] 889513003408 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889513003409 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 889513003410 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 889513003411 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513003412 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 889513003413 putative acyl-acceptor binding pocket; other site 889513003414 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 889513003415 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 889513003416 nucleotide binding site/active site [active] 889513003417 HIT family signature motif; other site 889513003418 catalytic residue [active] 889513003419 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 889513003420 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 889513003421 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 889513003422 active site 889513003423 dimer interface [polypeptide binding]; other site 889513003424 motif 1; other site 889513003425 motif 2; other site 889513003426 motif 3; other site 889513003427 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 889513003428 anticodon binding site; other site 889513003429 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 889513003430 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 889513003431 Protein of unknown function (DUF461); Region: DUF461; cl01071 889513003432 Bacterial Ig-like domain; Region: Big_5; cl01012 889513003433 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 889513003434 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 889513003435 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 889513003436 SelR domain; Region: SelR; pfam01641 889513003437 Chlorite dismutase; Region: Chlor_dismutase; cl01280 889513003438 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 889513003439 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 889513003440 catalytic site [active] 889513003441 putative active site [active] 889513003442 putative substrate binding site [chemical binding]; other site 889513003443 HRDC domain; Region: HRDC; cl02578 889513003444 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 889513003445 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 889513003446 TPP-binding site; other site 889513003447 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 889513003448 PYR/PP interface [polypeptide binding]; other site 889513003449 dimer interface [polypeptide binding]; other site 889513003450 TPP binding site [chemical binding]; other site 889513003451 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 889513003452 TRAM domain; Region: TRAM; cl01282 889513003453 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 889513003454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513003455 S-adenosylmethionine binding site [chemical binding]; other site 889513003456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513003457 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 889513003458 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 889513003459 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 889513003460 trimer interface [polypeptide binding]; other site 889513003461 active site 889513003462 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 889513003463 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 889513003464 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889513003465 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889513003466 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 889513003467 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 889513003468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889513003469 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 889513003470 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 889513003471 DNA binding residues [nucleotide binding] 889513003472 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 889513003473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513003474 ATP binding site [chemical binding]; other site 889513003475 putative Mg++ binding site [ion binding]; other site 889513003476 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 889513003477 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 889513003478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513003479 S-adenosylmethionine binding site [chemical binding]; other site 889513003480 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 889513003481 putative active site [active] 889513003482 dimerization interface [polypeptide binding]; other site 889513003483 putative tRNAtyr binding site [nucleotide binding]; other site 889513003484 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 889513003485 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 889513003486 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889513003487 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 889513003488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 889513003489 DNA binding residues [nucleotide binding] 889513003490 Helix-turn-helix domains; Region: HTH; cl00088 889513003491 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 889513003492 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 889513003493 FeoA domain; Region: FeoA; cl00838 889513003494 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 889513003495 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 889513003496 NAD binding site [chemical binding]; other site 889513003497 homodimer interface [polypeptide binding]; other site 889513003498 active site 889513003499 substrate binding site [chemical binding]; other site 889513003500 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 889513003501 PAC2 family; Region: PAC2; cl00847 889513003502 DEAD-like helicases superfamily; Region: DEXDc; smart00487 889513003503 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513003504 ATP binding site [chemical binding]; other site 889513003505 putative Mg++ binding site [ion binding]; other site 889513003506 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889513003507 nucleotide binding region [chemical binding]; other site 889513003508 ATP-binding site [chemical binding]; other site 889513003509 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 889513003510 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 889513003511 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 889513003512 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 889513003513 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 889513003514 dimer interface [polypeptide binding]; other site 889513003515 decamer (pentamer of dimers) interface [polypeptide binding]; other site 889513003516 catalytic triad [active] 889513003517 peroxidatic and resolving cysteines [active] 889513003518 Helix-turn-helix domains; Region: HTH; cl00088 889513003519 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 889513003520 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 889513003521 dimerization interface [polypeptide binding]; other site 889513003522 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 889513003523 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 889513003524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889513003525 ATP binding site [chemical binding]; other site 889513003526 putative Mg++ binding site [ion binding]; other site 889513003527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003528 Helicase associated domain (HA2); Region: HA2; cl04503 889513003529 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 889513003530 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 889513003531 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 889513003532 ATP cone domain; Region: ATP-cone; pfam03477 889513003533 LexA repressor; Validated; Region: PRK00215 889513003534 Helix-turn-helix domains; Region: HTH; cl00088 889513003535 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 889513003536 Catalytic site [active] 889513003537 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 889513003538 Helix-turn-helix domains; Region: HTH; cl00088 889513003539 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 889513003540 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 889513003541 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 889513003542 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 889513003543 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 889513003544 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 889513003545 Helix-turn-helix domains; Region: HTH; cl00088 889513003546 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 889513003547 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 889513003548 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 889513003549 putative substrate binding site [chemical binding]; other site 889513003550 putative ATP binding site [chemical binding]; other site 889513003551 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889513003552 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 889513003553 active site 889513003554 phosphorylation site [posttranslational modification] 889513003555 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 889513003556 active site 889513003557 P-loop; other site 889513003558 phosphorylation site [posttranslational modification] 889513003559 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889513003560 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 889513003561 dimerization domain swap beta strand [polypeptide binding]; other site 889513003562 regulatory protein interface [polypeptide binding]; other site 889513003563 active site 889513003564 regulatory phosphorylation site [posttranslational modification]; other site 889513003565 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 889513003566 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 889513003567 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889513003568 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 889513003569 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 889513003570 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 889513003571 HflX GTPase family; Region: HflX; cd01878 889513003572 G1 box; other site 889513003573 GTP/Mg2+ binding site [chemical binding]; other site 889513003574 Switch I region; other site 889513003575 G2 box; other site 889513003576 G3 box; other site 889513003577 Switch II region; other site 889513003578 GTPase RsgA; Reviewed; Region: PRK12288 889513003579 G4 box; other site 889513003580 G5 box; other site 889513003581 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 889513003582 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 889513003583 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 889513003584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003585 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 889513003586 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 889513003587 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 889513003588 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 889513003589 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 889513003590 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 889513003591 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889513003592 FeS/SAM binding site; other site 889513003593 RecX family; Region: RecX; cl00936 889513003594 recombinase A; Provisional; Region: recA; PRK09354 889513003595 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 889513003596 hexamer interface [polypeptide binding]; other site 889513003597 Walker A motif; other site 889513003598 ATP binding site [chemical binding]; other site 889513003599 Walker B motif; other site 889513003600 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 889513003601 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 889513003602 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889513003603 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889513003604 Walker A/P-loop; other site 889513003605 ATP binding site [chemical binding]; other site 889513003606 Q-loop/lid; other site 889513003607 ABC transporter signature motif; other site 889513003608 Walker B; other site 889513003609 D-loop; other site 889513003610 H-loop/switch region; other site 889513003611 Cobalt transport protein; Region: CbiQ; cl00463 889513003612 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 889513003613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889513003614 sequence-specific DNA binding site [nucleotide binding]; other site 889513003615 salt bridge; other site 889513003616 Competence-damaged protein; Region: CinA; cl00666 889513003617 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 889513003618 YCII-related domain; Region: YCII; cl00999 889513003619 Integral membrane protein TerC family; Region: TerC; cl10468 889513003620 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003621 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 889513003622 TIGR03085 family protein; Region: TIGR03085 889513003623 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 889513003624 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889513003625 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 889513003626 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 889513003627 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 889513003628 dimer interface [polypeptide binding]; other site 889513003629 active site 889513003630 catalytic residue [active] 889513003631 Thymidylate synthase complementing protein; Region: Thy1; cl03630 889513003632 dihydrodipicolinate reductase; Provisional; Region: PRK00048 889513003633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513003634 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 889513003635 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 889513003636 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 889513003637 oligomer interface [polypeptide binding]; other site 889513003638 RNA binding site [nucleotide binding]; other site 889513003639 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 889513003640 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 889513003641 RNase E interface [polypeptide binding]; other site 889513003642 trimer interface [polypeptide binding]; other site 889513003643 active site 889513003644 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 889513003645 putative nucleic acid binding region [nucleotide binding]; other site 889513003646 G-X-X-G motif; other site 889513003647 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 889513003648 RNA binding site [nucleotide binding]; other site 889513003649 domain interface; other site 889513003650 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 889513003651 16S/18S rRNA binding site [nucleotide binding]; other site 889513003652 S13e-L30e interaction site [polypeptide binding]; other site 889513003653 25S rRNA binding site [nucleotide binding]; other site 889513003654 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 889513003655 active site 889513003656 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 889513003657 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 889513003658 active site 889513003659 Riboflavin kinase; Region: Flavokinase; cl03312 889513003660 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 889513003661 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 889513003662 RNA binding site [nucleotide binding]; other site 889513003663 active site 889513003664 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 889513003665 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 889513003666 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 889513003667 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 889513003668 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 889513003669 active site 889513003670 metal binding site [ion binding]; metal-binding site 889513003671 MatE; Region: MatE; cl10513 889513003672 MatE; Region: MatE; cl10513 889513003673 DHH family; Region: DHH; pfam01368 889513003674 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 889513003675 Ribosome-binding factor A; Region: RBFA; cl00542 889513003676 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 889513003677 translation initiation factor IF-2; Region: IF-2; TIGR00487 889513003678 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 889513003679 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 889513003680 G1 box; other site 889513003681 putative GEF interaction site [polypeptide binding]; other site 889513003682 GTP/Mg2+ binding site [chemical binding]; other site 889513003683 Switch I region; other site 889513003684 G2 box; other site 889513003685 G3 box; other site 889513003686 Switch II region; other site 889513003687 G4 box; other site 889513003688 G5 box; other site 889513003689 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 889513003690 Translation-initiation factor 2; Region: IF-2; pfam11987 889513003691 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 889513003692 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 889513003693 putative RNA binding cleft [nucleotide binding]; other site 889513003694 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 889513003695 NusA N-terminal domain; Region: NusA_N; pfam08529 889513003696 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 889513003697 RNA binding site [nucleotide binding]; other site 889513003698 homodimer interface [polypeptide binding]; other site 889513003699 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 889513003700 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 889513003701 G-X-X-G motif; other site 889513003702 ribosome maturation protein RimP; Reviewed; Region: PRK00092 889513003703 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 889513003704 prolyl-tRNA synthetase; Provisional; Region: PRK09194 889513003705 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 889513003706 dimer interface [polypeptide binding]; other site 889513003707 motif 1; other site 889513003708 active site 889513003709 motif 2; other site 889513003710 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 889513003711 putative deacylase active site [active] 889513003712 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 889513003713 active site 889513003714 motif 3; other site 889513003715 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 889513003716 anticodon binding site; other site 889513003717 Protein of unknown function (DUF328); Region: DUF328; cl01143 889513003718 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 889513003719 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 889513003720 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 889513003721 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 889513003722 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003723 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 889513003724 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 889513003725 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 889513003726 DNA binding site [nucleotide binding] 889513003727 active site 889513003728 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 889513003729 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003730 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 889513003731 catalytic triad [active] 889513003732 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 889513003733 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 889513003734 homodimer interface [polypeptide binding]; other site 889513003735 Walker A motif; other site 889513003736 ATP binding site [chemical binding]; other site 889513003737 hydroxycobalamin binding site [chemical binding]; other site 889513003738 Walker B motif; other site 889513003739 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 889513003740 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 889513003741 metal ion-dependent adhesion site (MIDAS); other site 889513003742 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 889513003743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513003744 Walker A motif; other site 889513003745 ATP binding site [chemical binding]; other site 889513003746 Walker B motif; other site 889513003747 arginine finger; other site 889513003748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513003749 Predicted dehydrogenase [General function prediction only]; Region: COG0579 889513003750 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 889513003751 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513003752 mycothione reductase; Reviewed; Region: PRK07846 889513003753 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889513003754 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889513003755 cobyric acid synthase; Provisional; Region: PRK00784 889513003756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003757 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003758 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 889513003759 catalytic triad [active] 889513003760 methionine aminopeptidase; Provisional; Region: PRK12318 889513003761 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 889513003762 active site 889513003763 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 889513003764 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889513003765 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 889513003766 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 889513003767 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 889513003768 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 889513003769 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 889513003770 active site 889513003771 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 889513003772 protein binding site [polypeptide binding]; other site 889513003773 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 889513003774 putative substrate binding region [chemical binding]; other site 889513003775 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 889513003776 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 889513003777 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 889513003778 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 889513003779 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 889513003780 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 889513003781 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 889513003782 ribosome recycling factor; Reviewed; Region: frr; PRK00083 889513003783 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 889513003784 hinge region; other site 889513003785 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 889513003786 putative nucleotide binding site [chemical binding]; other site 889513003787 uridine monophosphate binding site [chemical binding]; other site 889513003788 homohexameric interface [polypeptide binding]; other site 889513003789 elongation factor Ts; Provisional; Region: tsf; PRK09377 889513003790 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 889513003791 Elongation factor TS; Region: EF_TS; pfam00889 889513003792 Elongation factor TS; Region: EF_TS; pfam00889 889513003793 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 889513003794 rRNA interaction site [nucleotide binding]; other site 889513003795 S8 interaction site; other site 889513003796 putative laminin-1 binding site; other site 889513003797 Peptidase family M23; Region: Peptidase_M23; pfam01551 889513003798 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 889513003799 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 889513003800 active site 889513003801 DNA binding site [nucleotide binding] 889513003802 Int/Topo IB signature motif; other site 889513003803 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 889513003804 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 889513003805 Restriction endonuclease; Region: Mrr_cat; cl00516 889513003806 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 889513003807 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 889513003808 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003809 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 889513003810 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 889513003811 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 889513003812 RNA/DNA hybrid binding site [nucleotide binding]; other site 889513003813 active site 889513003814 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 889513003815 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 889513003816 Catalytic site [active] 889513003817 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 889513003818 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 889513003819 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 889513003820 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 889513003821 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 889513003822 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 889513003823 RNA binding site [nucleotide binding]; other site 889513003824 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 889513003825 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 889513003826 active site 889513003827 P-loop; other site 889513003828 phosphorylation site [posttranslational modification] 889513003829 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889513003830 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889513003831 active site 889513003832 phosphorylation site [posttranslational modification] 889513003833 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 889513003834 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 889513003835 RimM N-terminal domain; Region: RimM; pfam01782 889513003836 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 889513003837 Cupin domain; Region: Cupin_2; cl09118 889513003838 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 889513003839 signal recognition particle protein; Provisional; Region: PRK10867 889513003840 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 889513003841 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 889513003842 P loop; other site 889513003843 GTP binding site [chemical binding]; other site 889513003844 Signal peptide binding domain; Region: SRP_SPB; pfam02978 889513003845 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 889513003846 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 889513003847 metal binding triad; other site 889513003848 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 889513003849 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 889513003850 Nitrogen regulatory protein P-II; Region: P-II; cl00412 889513003851 Nitrogen regulatory protein P-II; Region: P-II; smart00938 889513003852 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 889513003853 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 889513003854 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513003855 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 889513003856 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 889513003857 Walker A/P-loop; other site 889513003858 ATP binding site [chemical binding]; other site 889513003859 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 889513003860 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 889513003861 ABC transporter signature motif; other site 889513003862 Walker B; other site 889513003863 D-loop; other site 889513003864 H-loop/switch region; other site 889513003865 Acylphosphatase; Region: Acylphosphatase; cl00551 889513003866 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 889513003867 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 889513003868 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 889513003869 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 889513003870 DNA binding site [nucleotide binding] 889513003871 catalytic residue [active] 889513003872 H2TH interface [polypeptide binding]; other site 889513003873 putative catalytic residues [active] 889513003874 turnover-facilitating residue; other site 889513003875 intercalation triad [nucleotide binding]; other site 889513003876 8OG recognition residue [nucleotide binding]; other site 889513003877 putative reading head residues; other site 889513003878 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 889513003879 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 889513003880 ribonuclease III; Reviewed; Region: rnc; PRK00102 889513003881 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 889513003882 dimerization interface [polypeptide binding]; other site 889513003883 active site 889513003884 metal binding site [ion binding]; metal-binding site 889513003885 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 889513003886 dsRNA binding site [nucleotide binding]; other site 889513003887 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 889513003888 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 889513003889 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 889513003890 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 889513003891 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 889513003892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513003893 glutamate dehydrogenase; Provisional; Region: PRK09414 889513003894 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 889513003895 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 889513003896 NAD(P) binding site [chemical binding]; other site 889513003897 Glycerate kinase family; Region: Gly_kinase; cl00841 889513003898 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 889513003899 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 889513003900 nucleotide binding site/active site [active] 889513003901 HIT family signature motif; other site 889513003902 catalytic residue [active] 889513003903 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 889513003904 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 889513003905 metal binding site [ion binding]; metal-binding site 889513003906 putative dimer interface [polypeptide binding]; other site 889513003907 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 889513003908 homodimer interface [polypeptide binding]; other site 889513003909 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 889513003910 active site pocket [active] 889513003911 Electron transfer DM13; Region: DM13; cl02735 889513003912 pyruvate kinase; Provisional; Region: PRK06247 889513003913 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 889513003914 domain interfaces; other site 889513003915 active site 889513003916 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 889513003917 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 889513003918 active site 889513003919 ribulose/triose binding site [chemical binding]; other site 889513003920 phosphate binding site [ion binding]; other site 889513003921 substrate (anthranilate) binding pocket [chemical binding]; other site 889513003922 product (indole) binding pocket [chemical binding]; other site 889513003923 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 889513003924 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 889513003925 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 889513003926 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 889513003927 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 889513003928 substrate binding site [chemical binding]; other site 889513003929 glutamase interaction surface [polypeptide binding]; other site 889513003930 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 889513003931 active site 889513003932 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 889513003933 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 889513003934 catalytic residues [active] 889513003935 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 889513003936 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 889513003937 putative active site [active] 889513003938 oxyanion strand; other site 889513003939 catalytic triad [active] 889513003940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513003941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889513003942 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 889513003943 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 889513003944 putative active site pocket [active] 889513003945 4-fold oligomerization interface [polypeptide binding]; other site 889513003946 metal binding residues [ion binding]; metal-binding site 889513003947 3-fold/trimer interface [polypeptide binding]; other site 889513003948 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 889513003949 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889513003950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513003951 homodimer interface [polypeptide binding]; other site 889513003952 catalytic residue [active] 889513003953 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 889513003954 histidinol dehydrogenase; Region: hisD; TIGR00069 889513003955 NAD binding site [chemical binding]; other site 889513003956 dimerization interface [polypeptide binding]; other site 889513003957 product binding site; other site 889513003958 substrate binding site [chemical binding]; other site 889513003959 zinc binding site [ion binding]; other site 889513003960 catalytic residues [active] 889513003961 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 889513003962 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 889513003963 Helix-turn-helix domains; Region: HTH; cl00088 889513003964 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 889513003965 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 889513003966 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 889513003967 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 889513003968 active site 889513003969 catalytic site [active] 889513003970 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 889513003971 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 889513003972 active site 889513003973 catalytic site [active] 889513003974 substrate binding site [chemical binding]; other site 889513003975 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 889513003976 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 889513003977 synthetase active site [active] 889513003978 NTP binding site [chemical binding]; other site 889513003979 metal binding site [ion binding]; metal-binding site 889513003980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889513003981 RNA binding surface [nucleotide binding]; other site 889513003982 Uncharacterized conserved protein [Function unknown]; Region: COG1739 889513003983 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 889513003984 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 889513003985 threonine dehydratase; Validated; Region: PRK08639 889513003986 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 889513003987 tetramer interface [polypeptide binding]; other site 889513003988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513003989 catalytic residue [active] 889513003990 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 889513003991 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 889513003992 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 889513003993 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 889513003994 generic binding surface I; other site 889513003995 generic binding surface II; other site 889513003996 Predicted permeases [General function prediction only]; Region: RarD; COG2962 889513003997 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 889513003998 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 889513003999 active site 889513004000 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 889513004001 lipoprotein signal peptidase; Provisional; Region: PRK14787 889513004002 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 889513004003 active site 889513004004 homotetramer interface [polypeptide binding]; other site 889513004005 homodimer interface [polypeptide binding]; other site 889513004006 DNA polymerase IV; Provisional; Region: PRK03348 889513004007 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 889513004008 active site 889513004009 DNA binding site [nucleotide binding] 889513004010 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 889513004011 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 889513004012 HIGH motif; other site 889513004013 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 889513004014 active site 889513004015 KMSKS motif; other site 889513004016 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 889513004017 tRNA binding surface [nucleotide binding]; other site 889513004018 anticodon binding site; other site 889513004019 DivIVA domain; Region: DivI1A_domain; TIGR03544 889513004020 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 889513004021 YGGT family; Region: YGGT; cl00508 889513004022 Protein of unknown function (DUF552); Region: DUF552; cl00775 889513004023 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 889513004024 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 889513004025 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 889513004026 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 889513004027 nucleotide binding site [chemical binding]; other site 889513004028 SulA interaction site; other site 889513004029 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 889513004030 Cell division protein FtsQ; Region: FtsQ; pfam03799 889513004031 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 889513004032 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 889513004033 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889513004034 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889513004035 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 889513004036 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 889513004037 homodimer interface [polypeptide binding]; other site 889513004038 active site 889513004039 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 889513004040 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 889513004041 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889513004042 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 889513004043 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 889513004044 Mg++ binding site [ion binding]; other site 889513004045 putative catalytic motif [active] 889513004046 putative substrate binding site [chemical binding]; other site 889513004047 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 889513004048 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 889513004049 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889513004050 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889513004051 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 889513004052 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 889513004053 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889513004054 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889513004055 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 889513004056 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 889513004057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889513004058 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 889513004059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513004060 cell division protein MraZ; Reviewed; Region: PRK00326 889513004061 MraZ protein; Region: MraZ; pfam02381 889513004062 MraZ protein; Region: MraZ; pfam02381 889513004063 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 889513004064 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513004065 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 889513004066 substrate binding pocket [chemical binding]; other site 889513004067 chain length determination region; other site 889513004068 substrate-Mg2+ binding site; other site 889513004069 catalytic residues [active] 889513004070 aspartate-rich region 1; other site 889513004071 active site lid residues [active] 889513004072 aspartate-rich region 2; other site 889513004073 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 889513004074 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 889513004075 Catalytic domain of Protein Kinases; Region: PKc; cd00180 889513004076 active site 889513004077 ATP binding site [chemical binding]; other site 889513004078 substrate binding site [chemical binding]; other site 889513004079 activation loop (A-loop); other site 889513004080 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889513004081 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889513004082 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889513004083 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889513004084 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 889513004085 OpgC protein; Region: OpgC_C; cl00792 889513004086 Acyltransferase family; Region: Acyl_transf_3; pfam01757 889513004087 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 889513004088 putative acyl-acceptor binding pocket; other site 889513004089 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 889513004090 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889513004091 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 889513004092 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889513004093 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 889513004094 NlpC/P60 family; Region: NLPC_P60; cl11438 889513004095 NlpC/P60 family; Region: NLPC_P60; cl11438 889513004096 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 889513004097 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 889513004098 heme bH binding site [chemical binding]; other site 889513004099 intrachain domain interface; other site 889513004100 heme bL binding site [chemical binding]; other site 889513004101 interchain domain interface [polypeptide binding]; other site 889513004102 Qo binding site; other site 889513004103 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 889513004104 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 889513004105 iron-sulfur cluster [ion binding]; other site 889513004106 [2Fe-2S] cluster binding site [ion binding]; other site 889513004107 Cytochrome c; Region: Cytochrom_C; cl11414 889513004108 Cytochrome c; Region: Cytochrom_C; cl11414 889513004109 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 889513004110 Subunit I/III interface [polypeptide binding]; other site 889513004111 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 889513004112 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 889513004113 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 889513004114 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 889513004115 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 889513004116 active site 889513004117 dimer interface [polypeptide binding]; other site 889513004118 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 889513004119 Ligand Binding Site [chemical binding]; other site 889513004120 Molecular Tunnel; other site 889513004121 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 889513004122 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 889513004123 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 889513004124 homotrimer interface [polypeptide binding]; other site 889513004125 Walker A motif; other site 889513004126 GTP binding site [chemical binding]; other site 889513004127 Walker B motif; other site 889513004128 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 889513004129 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 889513004130 putative dimer interface [polypeptide binding]; other site 889513004131 active site pocket [active] 889513004132 putative cataytic base [active] 889513004133 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 889513004134 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 889513004135 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 889513004136 homodimer interface [polypeptide binding]; other site 889513004137 substrate-cofactor binding pocket; other site 889513004138 catalytic residue [active] 889513004139 multifunctional aminopeptidase A; Provisional; Region: PRK00913 889513004140 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 889513004141 interface (dimer of trimers) [polypeptide binding]; other site 889513004142 Substrate-binding/catalytic site; other site 889513004143 Zn-binding sites [ion binding]; other site 889513004144 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 889513004145 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 889513004146 E3 interaction surface; other site 889513004147 lipoyl attachment site [posttranslational modification]; other site 889513004148 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 889513004149 E3 interaction surface; other site 889513004150 lipoyl attachment site [posttranslational modification]; other site 889513004151 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 889513004152 E3 interaction surface; other site 889513004153 lipoyl attachment site [posttranslational modification]; other site 889513004154 e3 binding domain; Region: E3_binding; pfam02817 889513004155 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 889513004156 glycine dehydrogenase; Provisional; Region: PRK05367 889513004157 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 889513004158 tetramer interface [polypeptide binding]; other site 889513004159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513004160 catalytic residue [active] 889513004161 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 889513004162 tetramer interface [polypeptide binding]; other site 889513004163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513004164 catalytic residue [active] 889513004165 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 889513004166 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 889513004167 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 889513004168 lipoyl attachment site [posttranslational modification]; other site 889513004169 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 889513004170 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889513004171 active site 889513004172 metal binding site [ion binding]; metal-binding site 889513004173 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 889513004174 lipoyl synthase; Provisional; Region: PRK05481 889513004175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889513004176 FeS/SAM binding site; other site 889513004177 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 889513004178 RDD family; Region: RDD; cl00746 889513004179 glutamine synthetase, type I; Region: GlnA; TIGR00653 889513004180 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 889513004181 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 889513004182 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 889513004183 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 889513004184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889513004185 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 889513004186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513004187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513004188 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 889513004189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513004190 Walker A/P-loop; other site 889513004191 ATP binding site [chemical binding]; other site 889513004192 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 889513004193 putative active site [active] 889513004194 putative metal-binding site [ion binding]; other site 889513004195 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 889513004196 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 889513004197 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 889513004198 HsdM N-terminal domain; Region: HsdM_N; pfam12161 889513004199 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889513004200 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889513004201 Walker A/P-loop; other site 889513004202 ATP binding site [chemical binding]; other site 889513004203 Q-loop/lid; other site 889513004204 ABC transporter signature motif; other site 889513004205 Walker B; other site 889513004206 D-loop; other site 889513004207 H-loop/switch region; other site 889513004208 Htaa; Region: HtaA; pfam04213 889513004209 Htaa; Region: HtaA; pfam04213 889513004210 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889513004211 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 889513004212 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 889513004213 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 889513004214 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 889513004215 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 889513004216 active site 889513004217 CsbD-like; Region: CsbD; cl15799 889513004218 Predicted permease [General function prediction only]; Region: COG2056 889513004219 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 889513004220 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 889513004221 nudix motif; other site 889513004222 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 889513004223 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 889513004224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513004225 catalytic residue [active] 889513004226 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 889513004227 active site 889513004228 catalytic site [active] 889513004229 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 889513004230 heme binding pocket [chemical binding]; other site 889513004231 heme ligand [chemical binding]; other site 889513004232 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 889513004233 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 889513004234 metal binding triad; other site 889513004235 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 889513004236 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 889513004237 metal binding triad; other site 889513004238 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 889513004239 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 889513004240 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 889513004241 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 889513004242 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 889513004243 putative active site; other site 889513004244 putative metal binding residues [ion binding]; other site 889513004245 signature motif; other site 889513004246 putative triphosphate binding site [ion binding]; other site 889513004247 CHAD domain; Region: CHAD; cl10506 889513004248 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 889513004249 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 889513004250 RNB domain; Region: RNB; pfam00773 889513004251 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 889513004252 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 889513004253 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 889513004254 RNA/DNA hybrid binding site [nucleotide binding]; other site 889513004255 active site 889513004256 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889513004257 catalytic core [active] 889513004258 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 889513004259 Putative zinc ribbon domain; Region: DUF164; pfam02591 889513004260 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 889513004261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 889513004262 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 889513004263 hypothetical protein; Provisional; Region: PRK07908 889513004264 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889513004265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513004266 homodimer interface [polypeptide binding]; other site 889513004267 catalytic residue [active] 889513004268 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 889513004269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889513004270 motif II; other site 889513004271 Low molecular weight phosphatase family; Region: LMWPc; cd00115 889513004272 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 889513004273 CobD/Cbib protein; Region: CobD_Cbib; cl00561 889513004274 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 889513004275 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 889513004276 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 889513004277 dimer interface [polypeptide binding]; other site 889513004278 TPP-binding site [chemical binding]; other site 889513004279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 889513004280 Phosphopantetheine attachment site; Region: PP-binding; cl09936 889513004281 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 889513004282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889513004283 active site 889513004284 motif I; other site 889513004285 motif II; other site 889513004286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889513004287 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889513004288 UPF0126 domain; Region: UPF0126; pfam03458 889513004289 UPF0126 domain; Region: UPF0126; pfam03458 889513004290 DNA primase; Validated; Region: dnaG; PRK05667 889513004291 CHC2 zinc finger; Region: zf-CHC2; cl15369 889513004292 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 889513004293 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 889513004294 active site 889513004295 metal binding site [ion binding]; metal-binding site 889513004296 interdomain interaction site; other site 889513004297 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 889513004298 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 889513004299 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 889513004300 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 889513004301 glutaminase active site [active] 889513004302 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 889513004303 dimer interface [polypeptide binding]; other site 889513004304 active site 889513004305 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 889513004306 dimer interface [polypeptide binding]; other site 889513004307 active site 889513004308 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 889513004309 active site 889513004310 barstar interaction site; other site 889513004311 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 889513004312 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889513004313 Zn2+ binding site [ion binding]; other site 889513004314 Mg2+ binding site [ion binding]; other site 889513004315 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 889513004316 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 889513004317 putative active site [active] 889513004318 Repair protein; Region: Repair_PSII; cl01535 889513004319 glycyl-tRNA synthetase; Provisional; Region: PRK04173 889513004320 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 889513004321 motif 1; other site 889513004322 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 889513004323 dimer interface [polypeptide binding]; other site 889513004324 active site 889513004325 motif 2; other site 889513004326 motif 3; other site 889513004327 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 889513004328 anticodon binding site; other site 889513004329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889513004330 dimerization interface [polypeptide binding]; other site 889513004331 putative DNA binding site [nucleotide binding]; other site 889513004332 putative Zn2+ binding site [ion binding]; other site 889513004333 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 889513004334 metal binding site 2 [ion binding]; metal-binding site 889513004335 putative DNA binding helix; other site 889513004336 metal binding site 1 [ion binding]; metal-binding site 889513004337 dimer interface [polypeptide binding]; other site 889513004338 structural Zn2+ binding site [ion binding]; other site 889513004339 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 889513004340 diiron binding motif [ion binding]; other site 889513004341 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 889513004342 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 889513004343 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 889513004344 catalytic residue [active] 889513004345 putative FPP diphosphate binding site; other site 889513004346 putative FPP binding hydrophobic cleft; other site 889513004347 dimer interface [polypeptide binding]; other site 889513004348 putative IPP diphosphate binding site; other site 889513004349 Recombination protein O N terminal; Region: RecO_N; cl15812 889513004350 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 889513004351 Recombination protein O C terminal; Region: RecO_C; pfam02565 889513004352 GTPase Era; Reviewed; Region: era; PRK00089 889513004353 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 889513004354 G1 box; other site 889513004355 GTP/Mg2+ binding site [chemical binding]; other site 889513004356 Switch I region; other site 889513004357 G2 box; other site 889513004358 Switch II region; other site 889513004359 G3 box; other site 889513004360 G4 box; other site 889513004361 G5 box; other site 889513004362 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 889513004363 pyridoxamine kinase; Validated; Region: PRK05756 889513004364 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 889513004365 dimer interface [polypeptide binding]; other site 889513004366 pyridoxal binding site [chemical binding]; other site 889513004367 ATP binding site [chemical binding]; other site 889513004368 Domain of unknown function DUF21; Region: DUF21; pfam01595 889513004369 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 889513004370 Transporter associated domain; Region: CorC_HlyC; cl08393 889513004371 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 889513004372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513004373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 889513004374 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 889513004375 chaperone protein DnaJ; Provisional; Region: PRK14278 889513004376 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 889513004377 HSP70 interaction site [polypeptide binding]; other site 889513004378 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 889513004379 Zn binding sites [ion binding]; other site 889513004380 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 889513004381 dimer interface [polypeptide binding]; other site 889513004382 coproporphyrinogen III oxidase; Validated; Region: PRK05628 889513004383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889513004384 FeS/SAM binding site; other site 889513004385 HemN C-terminal domain; Region: HemN_C; pfam06969 889513004386 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 889513004387 AMP-binding enzyme; Region: AMP-binding; cl15778 889513004388 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 889513004389 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 889513004390 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 889513004391 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 889513004392 active site 889513004393 Zn binding site [ion binding]; other site 889513004394 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513004395 substrate binding pocket [chemical binding]; other site 889513004396 catalytic triad [active] 889513004397 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 889513004398 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 889513004399 active site 889513004400 metal binding site [ion binding]; metal-binding site 889513004401 nudix motif; other site 889513004402 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 889513004403 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 889513004404 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 889513004405 active site 889513004406 BCCT family transporter; Region: BCCT; cl00569 889513004407 Membrane transport protein; Region: Mem_trans; cl09117 889513004408 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 889513004409 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 889513004410 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889513004411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513004412 dimer interface [polypeptide binding]; other site 889513004413 conserved gate region; other site 889513004414 putative PBP binding loops; other site 889513004415 ABC-ATPase subunit interface; other site 889513004416 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 889513004417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513004418 dimer interface [polypeptide binding]; other site 889513004419 conserved gate region; other site 889513004420 putative PBP binding loops; other site 889513004421 ABC-ATPase subunit interface; other site 889513004422 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 889513004423 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513004424 Walker A/P-loop; other site 889513004425 ATP binding site [chemical binding]; other site 889513004426 Q-loop/lid; other site 889513004427 ABC transporter signature motif; other site 889513004428 Walker B; other site 889513004429 D-loop; other site 889513004430 H-loop/switch region; other site 889513004431 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889513004432 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513004433 Walker A/P-loop; other site 889513004434 ATP binding site [chemical binding]; other site 889513004435 Q-loop/lid; other site 889513004436 ABC transporter signature motif; other site 889513004437 Walker B; other site 889513004438 D-loop; other site 889513004439 H-loop/switch region; other site 889513004440 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889513004441 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 889513004442 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 889513004443 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889513004444 catalytic residue [active] 889513004445 putative inner membrane protein; Provisional; Region: PRK11099 889513004446 Sulphur transport; Region: Sulf_transp; cl01018 889513004447 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 889513004448 CPxP motif; other site 889513004449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 889513004450 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 889513004451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 889513004452 multidrug resistance protein MdtH; Provisional; Region: PRK11646 889513004453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 889513004454 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513004455 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 889513004456 Walker A/P-loop; other site 889513004457 ATP binding site [chemical binding]; other site 889513004458 Q-loop/lid; other site 889513004459 ABC transporter signature motif; other site 889513004460 Walker B; other site 889513004461 D-loop; other site 889513004462 H-loop/switch region; other site 889513004463 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889513004464 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513004465 Walker A/P-loop; other site 889513004466 ATP binding site [chemical binding]; other site 889513004467 Q-loop/lid; other site 889513004468 ABC transporter signature motif; other site 889513004469 Walker B; other site 889513004470 D-loop; other site 889513004471 H-loop/switch region; other site 889513004472 GTP-binding protein LepA; Provisional; Region: PRK05433 889513004473 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 889513004474 G1 box; other site 889513004475 putative GEF interaction site [polypeptide binding]; other site 889513004476 GTP/Mg2+ binding site [chemical binding]; other site 889513004477 Switch I region; other site 889513004478 G2 box; other site 889513004479 G3 box; other site 889513004480 Switch II region; other site 889513004481 G4 box; other site 889513004482 G5 box; other site 889513004483 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 889513004484 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 889513004485 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 889513004486 PemK-like protein; Region: PemK; cl00995 889513004487 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 889513004488 LysE type translocator; Region: LysE; cl00565 889513004489 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 889513004490 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 889513004491 hypothetical protein; Validated; Region: PRK05629 889513004492 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 889513004493 Competence protein; Region: Competence; cl00471 889513004494 comEA protein; Region: comE; TIGR01259 889513004495 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 889513004496 Oligomerisation domain; Region: Oligomerisation; cl00519 889513004497 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 889513004498 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 889513004499 active site 889513004500 (T/H)XGH motif; other site 889513004501 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 889513004502 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 889513004503 putative catalytic cysteine [active] 889513004504 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 889513004505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513004506 Protein of unknown function (DUF454); Region: DUF454; cl01063 889513004507 putative transporter; Validated; Region: PRK03818 889513004508 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 889513004509 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889513004510 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889513004511 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 889513004512 gamma-glutamyl kinase; Provisional; Region: PRK05429 889513004513 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 889513004514 nucleotide binding site [chemical binding]; other site 889513004515 homotetrameric interface [polypeptide binding]; other site 889513004516 putative phosphate binding site [ion binding]; other site 889513004517 putative allosteric binding site; other site 889513004518 PUA domain; Region: PUA; cl00607 889513004519 GTPase CgtA; Reviewed; Region: obgE; PRK12296 889513004520 GTP1/OBG; Region: GTP1_OBG; pfam01018 889513004521 Obg GTPase; Region: Obg; cd01898 889513004522 G1 box; other site 889513004523 GTP/Mg2+ binding site [chemical binding]; other site 889513004524 Switch I region; other site 889513004525 G2 box; other site 889513004526 G3 box; other site 889513004527 Switch II region; other site 889513004528 G4 box; other site 889513004529 G5 box; other site 889513004530 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 889513004531 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 889513004532 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 889513004533 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 889513004534 translation initiation factor IF-2; Validated; Region: infB; PRK05306 889513004535 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 889513004536 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 889513004537 homodimer interface [polypeptide binding]; other site 889513004538 oligonucleotide binding site [chemical binding]; other site 889513004539 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 889513004540 active site 889513004541 multimer interface [polypeptide binding]; other site 889513004542 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 889513004543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513004544 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 889513004545 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 889513004546 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889513004547 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889513004548 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889513004549 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 889513004550 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889513004551 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 889513004552 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 889513004553 active site 889513004554 KMSKS motif; other site 889513004555 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 889513004556 tRNA binding surface [nucleotide binding]; other site 889513004557 anticodon binding site; other site 889513004558 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 889513004559 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 889513004560 malate dehydrogenase; Provisional; Region: PRK05442 889513004561 NAD(P) binding site [chemical binding]; other site 889513004562 dimer interface [polypeptide binding]; other site 889513004563 malate binding site [chemical binding]; other site 889513004564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889513004565 Helix-turn-helix domains; Region: HTH; cl00088 889513004566 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 889513004567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513004568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513004569 Walker A motif; other site 889513004570 ATP binding site [chemical binding]; other site 889513004571 Walker B motif; other site 889513004572 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 889513004573 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 889513004574 glutamine binding [chemical binding]; other site 889513004575 catalytic triad [active] 889513004576 hypothetical protein; Validated; Region: PRK09070 889513004577 chorismate binding enzyme; Region: Chorismate_bind; cl10555 889513004578 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 889513004579 substrate-cofactor binding pocket; other site 889513004580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513004581 catalytic residue [active] 889513004582 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 889513004583 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 889513004584 oligomer interface [polypeptide binding]; other site 889513004585 active site residues [active] 889513004586 Clp protease; Region: CLP_protease; pfam00574 889513004587 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 889513004588 oligomer interface [polypeptide binding]; other site 889513004589 active site residues [active] 889513004590 trigger factor; Provisional; Region: tig; PRK01490 889513004591 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 889513004592 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 889513004593 Pirin-related protein [General function prediction only]; Region: COG1741 889513004594 Cupin domain; Region: Cupin_2; cl09118 889513004595 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 889513004596 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 889513004597 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 889513004598 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 889513004599 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 889513004600 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 889513004601 Zn binding site [ion binding]; other site 889513004602 Mechanosensitive ion channel; Region: MS_channel; pfam00924 889513004603 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 889513004604 apolar tunnel; other site 889513004605 heme binding site [chemical binding]; other site 889513004606 dimerization interface [polypeptide binding]; other site 889513004607 Protein of unknown function, DUF606; Region: DUF606; cl01273 889513004608 Protein of unknown function, DUF606; Region: DUF606; cl01273 889513004609 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 889513004610 active site 889513004611 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 889513004612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513004613 Walker A/P-loop; other site 889513004614 ATP binding site [chemical binding]; other site 889513004615 Q-loop/lid; other site 889513004616 ABC transporter signature motif; other site 889513004617 Walker B; other site 889513004618 D-loop; other site 889513004619 H-loop/switch region; other site 889513004620 ABC transporter; Region: ABC_tran_2; pfam12848 889513004621 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889513004622 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 889513004623 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 889513004624 dimer interface [polypeptide binding]; other site 889513004625 ssDNA binding site [nucleotide binding]; other site 889513004626 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889513004627 YcaO-like family; Region: YcaO; pfam02624 889513004628 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 889513004629 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 889513004630 NADPH bind site [chemical binding]; other site 889513004631 putative FMN binding site [chemical binding]; other site 889513004632 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 889513004633 SpaB C-terminal domain; Region: SpaB_C; cl14828 889513004634 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 889513004635 YcaO-like family; Region: YcaO; pfam02624 889513004636 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 889513004637 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889513004638 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889513004639 Walker A/P-loop; other site 889513004640 ATP binding site [chemical binding]; other site 889513004641 Q-loop/lid; other site 889513004642 ABC transporter signature motif; other site 889513004643 Walker B; other site 889513004644 D-loop; other site 889513004645 H-loop/switch region; other site 889513004646 Copper resistance protein D; Region: CopD; cl00563 889513004647 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 889513004648 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 889513004649 Carbon starvation protein CstA; Region: CstA; pfam02554 889513004650 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 889513004651 Protein of unknown function (DUF466); Region: DUF466; cl01082 889513004652 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 889513004653 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 889513004654 active site 889513004655 catalytic triad [active] 889513004656 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 889513004657 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 889513004658 NADP binding site [chemical binding]; other site 889513004659 dimer interface [polypeptide binding]; other site 889513004660 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 889513004661 classical (c) SDRs; Region: SDR_c; cd05233 889513004662 NAD(P) binding site [chemical binding]; other site 889513004663 active site 889513004664 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 889513004665 catalytic site [active] 889513004666 putative active site [active] 889513004667 putative substrate binding site [chemical binding]; other site 889513004668 dimer interface [polypeptide binding]; other site 889513004669 N-acetylneuraminate lyase; Region: nanA; TIGR00683 889513004670 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 889513004671 inhibitor site; inhibition site 889513004672 active site 889513004673 dimer interface [polypeptide binding]; other site 889513004674 catalytic residue [active] 889513004675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 889513004676 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 889513004677 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 889513004678 Prostaglandin dehydrogenases; Region: PGDH; cd05288 889513004679 NAD(P) binding site [chemical binding]; other site 889513004680 substrate binding site [chemical binding]; other site 889513004681 dimer interface [polypeptide binding]; other site 889513004682 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 889513004683 Isochorismatase family; Region: Isochorismatase; pfam00857 889513004684 catalytic triad [active] 889513004685 metal binding site [ion binding]; metal-binding site 889513004686 conserved cis-peptide bond; other site 889513004687 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 889513004688 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 889513004689 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 889513004690 catalytic triad [active] 889513004691 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 889513004692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889513004693 Helix-turn-helix domains; Region: HTH; cl00088 889513004694 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 889513004695 Acyl transferase domain; Region: Acyl_transf_1; cl08282 889513004696 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 889513004697 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 889513004698 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 889513004699 FMN binding site [chemical binding]; other site 889513004700 substrate binding site [chemical binding]; other site 889513004701 putative catalytic residue [active] 889513004702 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 889513004703 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 889513004704 active site 2 [active] 889513004705 active site 1 [active] 889513004706 Acyl transferase domain; Region: Acyl_transf_1; cl08282 889513004707 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 889513004708 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 889513004709 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 889513004710 putative NAD(P) binding site [chemical binding]; other site 889513004711 active site 889513004712 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 889513004713 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 889513004714 active site 889513004715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 889513004716 Histidine kinase; Region: HisKA_3; pfam07730 889513004717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 889513004718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 889513004719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889513004720 active site 889513004721 phosphorylation site [posttranslational modification] 889513004722 intermolecular recognition site; other site 889513004723 dimerization interface [polypeptide binding]; other site 889513004724 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889513004725 DNA binding residues [nucleotide binding] 889513004726 dimerization interface [polypeptide binding]; other site 889513004727 Protein of unknown function (DUF418); Region: DUF418; cl12135 889513004728 CAAX protease self-immunity; Region: Abi; cl00558 889513004729 Glucitol operon activator protein (GutM); Region: GutM; cl01890 889513004730 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 889513004731 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 889513004732 active site 889513004733 dimerization interface [polypeptide binding]; other site 889513004734 ribonuclease PH; Reviewed; Region: rph; PRK00173 889513004735 Ribonuclease PH; Region: RNase_PH_bact; cd11362 889513004736 hexamer interface [polypeptide binding]; other site 889513004737 active site 889513004738 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889513004739 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 889513004740 Rhomboid family; Region: Rhomboid; cl11446 889513004741 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 889513004742 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 889513004743 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 889513004744 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 889513004745 active site 889513004746 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 889513004747 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513004748 DEAD_2; Region: DEAD_2; pfam06733 889513004749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513004750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 889513004751 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513004752 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 889513004753 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 889513004754 phosphoserine phosphatase SerB; Region: serB; TIGR00338 889513004755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889513004756 motif II; other site 889513004757 Helix-turn-helix domains; Region: HTH; cl00088 889513004758 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 889513004759 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 889513004760 D-pathway; other site 889513004761 Putative ubiquinol binding site [chemical binding]; other site 889513004762 Low-spin heme (heme b) binding site [chemical binding]; other site 889513004763 Putative water exit pathway; other site 889513004764 Binuclear center (heme o3/CuB) [ion binding]; other site 889513004765 K-pathway; other site 889513004766 Putative proton exit pathway; other site 889513004767 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 889513004768 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 889513004769 dimer interface [polypeptide binding]; other site 889513004770 putative radical transfer pathway; other site 889513004771 diiron center [ion binding]; other site 889513004772 tyrosyl radical; other site 889513004773 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 889513004774 Ferritin-like domain; Region: Ferritin; pfam00210 889513004775 ferroxidase diiron center [ion binding]; other site 889513004776 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 889513004777 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 889513004778 Class I ribonucleotide reductase; Region: RNR_I; cd01679 889513004779 active site 889513004780 dimer interface [polypeptide binding]; other site 889513004781 catalytic residues [active] 889513004782 effector binding site; other site 889513004783 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 889513004784 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889513004785 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 889513004786 catalytic residues [active] 889513004787 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 889513004788 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 889513004789 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 889513004790 homodimer interface [polypeptide binding]; other site 889513004791 NAD binding pocket [chemical binding]; other site 889513004792 ATP binding pocket [chemical binding]; other site 889513004793 Mg binding site [ion binding]; other site 889513004794 active-site loop [active] 889513004795 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 889513004796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889513004797 dimerization interface [polypeptide binding]; other site 889513004798 putative DNA binding site [nucleotide binding]; other site 889513004799 putative Zn2+ binding site [ion binding]; other site 889513004800 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 889513004801 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 889513004802 DoxX; Region: DoxX; cl00976 889513004803 phosphoglucomutase; Validated; Region: PRK07564 889513004804 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 889513004805 active site 889513004806 substrate binding site [chemical binding]; other site 889513004807 metal binding site [ion binding]; metal-binding site 889513004808 CrcB-like protein; Region: CRCB; cl09114 889513004809 CrcB-like protein; Region: CRCB; cl09114 889513004810 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889513004811 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 889513004812 FtsX-like permease family; Region: FtsX; cl15850 889513004813 FtsX-like permease family; Region: FtsX; cl15850 889513004814 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889513004815 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889513004816 Walker A/P-loop; other site 889513004817 ATP binding site [chemical binding]; other site 889513004818 Q-loop/lid; other site 889513004819 ABC transporter signature motif; other site 889513004820 Walker B; other site 889513004821 D-loop; other site 889513004822 H-loop/switch region; other site 889513004823 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 889513004824 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 889513004825 hinge; other site 889513004826 active site 889513004827 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 889513004828 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 889513004829 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889513004830 DNA binding residues [nucleotide binding] 889513004831 dimerization interface [polypeptide binding]; other site 889513004832 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 889513004833 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 889513004834 dimer interface [polypeptide binding]; other site 889513004835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513004836 catalytic residue [active] 889513004837 serine O-acetyltransferase; Region: cysE; TIGR01172 889513004838 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 889513004839 trimer interface [polypeptide binding]; other site 889513004840 active site 889513004841 substrate binding site [chemical binding]; other site 889513004842 CoA binding site [chemical binding]; other site 889513004843 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513004844 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 889513004845 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 889513004846 putative active site [active] 889513004847 metal binding site [ion binding]; metal-binding site 889513004848 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 889513004849 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 889513004850 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 889513004851 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 889513004852 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889513004853 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513004854 Walker A/P-loop; other site 889513004855 ATP binding site [chemical binding]; other site 889513004856 Q-loop/lid; other site 889513004857 ABC transporter signature motif; other site 889513004858 Walker B; other site 889513004859 H-loop/switch region; other site 889513004860 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 889513004861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513004862 Walker A/P-loop; other site 889513004863 ATP binding site [chemical binding]; other site 889513004864 Q-loop/lid; other site 889513004865 ABC transporter signature motif; other site 889513004866 Walker B; other site 889513004867 D-loop; other site 889513004868 H-loop/switch region; other site 889513004869 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 889513004870 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 889513004871 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 889513004872 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 889513004873 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 889513004874 FMN binding site [chemical binding]; other site 889513004875 active site 889513004876 catalytic residues [active] 889513004877 substrate binding site [chemical binding]; other site 889513004878 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 889513004879 PhoU domain; Region: PhoU; pfam01895 889513004880 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 889513004881 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 889513004882 Walker A/P-loop; other site 889513004883 ATP binding site [chemical binding]; other site 889513004884 Q-loop/lid; other site 889513004885 ABC transporter signature motif; other site 889513004886 Walker B; other site 889513004887 D-loop; other site 889513004888 H-loop/switch region; other site 889513004889 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 889513004890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513004891 dimer interface [polypeptide binding]; other site 889513004892 conserved gate region; other site 889513004893 putative PBP binding loops; other site 889513004894 ABC-ATPase subunit interface; other site 889513004895 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889513004896 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 889513004897 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513004898 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513004899 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 889513004900 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 889513004901 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 889513004902 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 889513004903 heme-binding site [chemical binding]; other site 889513004904 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 889513004905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513004906 catalytic residue [active] 889513004907 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 889513004908 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 889513004909 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 889513004910 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 889513004911 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 889513004912 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 889513004913 dimerization interface [polypeptide binding]; other site 889513004914 putative ATP binding site [chemical binding]; other site 889513004915 amidophosphoribosyltransferase; Provisional; Region: PRK07847 889513004916 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 889513004917 active site 889513004918 tetramer interface [polypeptide binding]; other site 889513004919 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889513004920 active site 889513004921 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889513004922 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 889513004923 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 889513004924 dimer interface [polypeptide binding]; other site 889513004925 putative radical transfer pathway; other site 889513004926 diiron center [ion binding]; other site 889513004927 tyrosyl radical; other site 889513004928 Haemolysin-III related; Region: HlyIII; cl03831 889513004929 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 889513004930 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 889513004931 dimerization interface [polypeptide binding]; other site 889513004932 ATP binding site [chemical binding]; other site 889513004933 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 889513004934 dimerization interface [polypeptide binding]; other site 889513004935 ATP binding site [chemical binding]; other site 889513004936 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 889513004937 putative active site [active] 889513004938 catalytic triad [active] 889513004939 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 889513004940 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 889513004941 catalytic residues [active] 889513004942 dimer interface [polypeptide binding]; other site 889513004943 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 889513004944 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513004945 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 889513004946 ATP binding site [chemical binding]; other site 889513004947 active site 889513004948 substrate binding site [chemical binding]; other site 889513004949 adenylosuccinate lyase; Region: purB; TIGR00928 889513004950 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 889513004951 tetramer interface [polypeptide binding]; other site 889513004952 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 889513004953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513004954 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889513004955 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 889513004956 Cation transport protein; Region: TrkH; cl10514 889513004957 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 889513004958 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 889513004959 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889513004960 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 889513004961 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 889513004962 nucleotide binding site/active site [active] 889513004963 HIT family signature motif; other site 889513004964 catalytic residue [active] 889513004965 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 889513004966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 889513004967 dimerization interface [polypeptide binding]; other site 889513004968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889513004969 dimer interface [polypeptide binding]; other site 889513004970 phosphorylation site [posttranslational modification] 889513004971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889513004972 ATP binding site [chemical binding]; other site 889513004973 Mg2+ binding site [ion binding]; other site 889513004974 G-X-G motif; other site 889513004975 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889513004976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889513004977 active site 889513004978 phosphorylation site [posttranslational modification] 889513004979 intermolecular recognition site; other site 889513004980 dimerization interface [polypeptide binding]; other site 889513004981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889513004982 DNA binding site [nucleotide binding] 889513004983 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889513004984 Helix-turn-helix domains; Region: HTH; cl00088 889513004985 Predicted esterase [General function prediction only]; Region: COG0627 889513004986 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513004987 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 889513004988 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 889513004989 putative active site [active] 889513004990 pyruvate dehydrogenase; Provisional; Region: PRK06546 889513004991 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 889513004992 PYR/PP interface [polypeptide binding]; other site 889513004993 tetramer interface [polypeptide binding]; other site 889513004994 dimer interface [polypeptide binding]; other site 889513004995 TPP binding site [chemical binding]; other site 889513004996 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 889513004997 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 889513004998 TPP-binding site [chemical binding]; other site 889513004999 Uncharacterized conserved protein [Function unknown]; Region: COG2966 889513005000 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 889513005001 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 889513005002 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 889513005003 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 889513005004 active site 889513005005 homotetramer interface [polypeptide binding]; other site 889513005006 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 889513005007 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889513005008 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889513005009 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889513005010 DNA binding site [nucleotide binding] 889513005011 domain linker motif; other site 889513005012 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 889513005013 putative dimerization interface [polypeptide binding]; other site 889513005014 putative ligand binding site [chemical binding]; other site 889513005015 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 889513005016 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 889513005017 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 889513005018 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 889513005019 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 889513005020 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889513005021 active site 889513005022 HIGH motif; other site 889513005023 nucleotide binding site [chemical binding]; other site 889513005024 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 889513005025 KMSKS motif; other site 889513005026 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 889513005027 tRNA binding surface [nucleotide binding]; other site 889513005028 anticodon binding site; other site 889513005029 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 889513005030 homotrimer interaction site [polypeptide binding]; other site 889513005031 zinc binding site [ion binding]; other site 889513005032 CDP-binding sites; other site 889513005033 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 889513005034 substrate binding site; other site 889513005035 dimer interface; other site 889513005036 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 889513005037 DNA repair protein RadA; Provisional; Region: PRK11823 889513005038 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513005039 Walker A motif; other site 889513005040 ATP binding site [chemical binding]; other site 889513005041 Walker B motif; other site 889513005042 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 889513005043 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 889513005044 active site clefts [active] 889513005045 zinc binding site [ion binding]; other site 889513005046 dimer interface [polypeptide binding]; other site 889513005047 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 889513005048 endonuclease III; Region: ENDO3c; smart00478 889513005049 minor groove reading motif; other site 889513005050 helix-hairpin-helix signature motif; other site 889513005051 substrate binding pocket [chemical binding]; other site 889513005052 active site 889513005053 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 889513005054 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 889513005055 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 889513005056 Clp protease ATP binding subunit; Region: clpC; CHL00095 889513005057 Clp amino terminal domain; Region: Clp_N; pfam02861 889513005058 Clp amino terminal domain; Region: Clp_N; pfam02861 889513005059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513005060 Walker A motif; other site 889513005061 ATP binding site [chemical binding]; other site 889513005062 Walker B motif; other site 889513005063 arginine finger; other site 889513005064 UvrB/uvrC motif; Region: UVR; pfam02151 889513005065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513005066 Walker A motif; other site 889513005067 ATP binding site [chemical binding]; other site 889513005068 Walker B motif; other site 889513005069 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 889513005070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513005071 putative substrate translocation pore; other site 889513005072 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 889513005073 active site 889513005074 tetramer interface [polypeptide binding]; other site 889513005075 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 889513005076 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513005077 CAAX protease self-immunity; Region: Abi; cl00558 889513005078 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 889513005079 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 889513005080 dimer interface [polypeptide binding]; other site 889513005081 putative anticodon binding site; other site 889513005082 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 889513005083 motif 1; other site 889513005084 active site 889513005085 motif 2; other site 889513005086 motif 3; other site 889513005087 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 889513005088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 889513005089 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 889513005090 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 889513005091 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 889513005092 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 889513005093 NAD(P) binding site [chemical binding]; other site 889513005094 catalytic residues [active] 889513005095 choline dehydrogenase; Validated; Region: PRK02106 889513005096 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 889513005097 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889513005098 pantoate--beta-alanine ligase; Region: panC; TIGR00018 889513005099 active site 889513005100 nucleotide binding site [chemical binding]; other site 889513005101 HIGH motif; other site 889513005102 KMSKS motif; other site 889513005103 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 889513005104 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 889513005105 catalytic center binding site [active] 889513005106 ATP binding site [chemical binding]; other site 889513005107 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 889513005108 homooctamer interface [polypeptide binding]; other site 889513005109 active site 889513005110 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 889513005111 dihydropteroate synthase; Region: DHPS; TIGR01496 889513005112 substrate binding pocket [chemical binding]; other site 889513005113 dimer interface [polypeptide binding]; other site 889513005114 inhibitor binding site; inhibition site 889513005115 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 889513005116 GTP cyclohydrolase I; Provisional; Region: PLN03044 889513005117 homodecamer interface [polypeptide binding]; other site 889513005118 active site 889513005119 putative catalytic site residues [active] 889513005120 zinc binding site [ion binding]; other site 889513005121 GTP-CH-I/GFRP interaction surface; other site 889513005122 FtsH Extracellular; Region: FtsH_ext; pfam06480 889513005123 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 889513005124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513005125 Walker A motif; other site 889513005126 ATP binding site [chemical binding]; other site 889513005127 Walker B motif; other site 889513005128 arginine finger; other site 889513005129 Peptidase family M41; Region: Peptidase_M41; pfam01434 889513005130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889513005131 active site 889513005132 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 889513005133 Ligand Binding Site [chemical binding]; other site 889513005134 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889513005135 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 889513005136 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 889513005137 dimer interface [polypeptide binding]; other site 889513005138 substrate binding site [chemical binding]; other site 889513005139 metal binding sites [ion binding]; metal-binding site 889513005140 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 889513005141 active site residue [active] 889513005142 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 889513005143 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 889513005144 Secretory lipase; Region: LIP; pfam03583 889513005145 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889513005146 Helix-turn-helix domains; Region: HTH; cl00088 889513005147 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 889513005148 AMP-binding enzyme; Region: AMP-binding; cl15778 889513005149 Phosphopantetheine attachment site; Region: PP-binding; cl09936 889513005150 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 889513005151 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 889513005152 putative trimer interface [polypeptide binding]; other site 889513005153 putative CoA binding site [chemical binding]; other site 889513005154 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 889513005155 putative trimer interface [polypeptide binding]; other site 889513005156 putative CoA binding site [chemical binding]; other site 889513005157 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 889513005158 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 889513005159 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 889513005160 ring oligomerisation interface [polypeptide binding]; other site 889513005161 ATP/Mg binding site [chemical binding]; other site 889513005162 stacking interactions; other site 889513005163 hinge regions; other site 889513005164 hypothetical protein; Provisional; Region: PRK07907 889513005165 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 889513005166 active site 889513005167 metal binding site [ion binding]; metal-binding site 889513005168 dimer interface [polypeptide binding]; other site 889513005169 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 889513005170 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 889513005171 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 889513005172 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 889513005173 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 889513005174 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 889513005175 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 889513005176 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 889513005177 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 889513005178 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 889513005179 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 889513005180 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 889513005181 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 889513005182 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 889513005183 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 889513005184 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 889513005185 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 889513005186 active site 889513005187 catalytic residues [active] 889513005188 metal binding site [ion binding]; metal-binding site 889513005189 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 889513005190 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513005191 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 889513005192 putative catalytic site [active] 889513005193 putative phosphate binding site [ion binding]; other site 889513005194 active site 889513005195 metal binding site A [ion binding]; metal-binding site 889513005196 DNA binding site [nucleotide binding] 889513005197 putative AP binding site [nucleotide binding]; other site 889513005198 putative metal binding site B [ion binding]; other site 889513005199 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 889513005200 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 889513005201 putative active site [active] 889513005202 catalytic site [active] 889513005203 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 889513005204 putative active site [active] 889513005205 catalytic site [active] 889513005206 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 889513005207 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889513005208 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 889513005209 Walker A/P-loop; other site 889513005210 ATP binding site [chemical binding]; other site 889513005211 Q-loop/lid; other site 889513005212 ABC transporter signature motif; other site 889513005213 Walker B; other site 889513005214 D-loop; other site 889513005215 H-loop/switch region; other site 889513005216 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 889513005217 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 889513005218 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 889513005219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889513005220 substrate binding pocket [chemical binding]; other site 889513005221 membrane-bound complex binding site; other site 889513005222 hinge residues; other site 889513005223 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 889513005224 Catalytic domain of Protein Kinases; Region: PKc; cd00180 889513005225 active site 889513005226 ATP binding site [chemical binding]; other site 889513005227 substrate binding site [chemical binding]; other site 889513005228 activation loop (A-loop); other site 889513005229 acetate kinase; Region: ackA; TIGR00016 889513005230 Acetokinase family; Region: Acetate_kinase; cl01029 889513005231 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 889513005232 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 889513005233 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 889513005234 ferredoxin-NADP+ reductase; Region: PLN02852 889513005235 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889513005236 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 889513005237 active site 889513005238 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 889513005239 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889513005240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889513005241 active site 889513005242 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 889513005243 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 889513005244 catalytic residues [active] 889513005245 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 889513005246 ResB-like family; Region: ResB; pfam05140 889513005247 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 889513005248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 889513005249 TPR motif; other site 889513005250 TPR repeat; Region: TPR_11; pfam13414 889513005251 binding surface 889513005252 Cytochrome c552; Region: Cytochrom_C552; pfam02335 889513005253 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 889513005254 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 889513005255 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 889513005256 GDP-binding site [chemical binding]; other site 889513005257 ACT binding site; other site 889513005258 IMP binding site; other site 889513005259 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 889513005260 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513005261 Walker A/P-loop; other site 889513005262 ATP binding site [chemical binding]; other site 889513005263 Q-loop/lid; other site 889513005264 ABC transporter signature motif; other site 889513005265 Walker B; other site 889513005266 D-loop; other site 889513005267 H-loop/switch region; other site 889513005268 Helix-turn-helix domains; Region: HTH; cl00088 889513005269 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 889513005270 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 889513005271 active site 889513005272 intersubunit interface [polypeptide binding]; other site 889513005273 zinc binding site [ion binding]; other site 889513005274 Na+ binding site [ion binding]; other site 889513005275 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 889513005276 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 889513005277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889513005278 active site 889513005279 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 889513005280 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 889513005281 active site residue [active] 889513005282 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 889513005283 active site residue [active] 889513005284 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 889513005285 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 889513005286 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 889513005287 Gram positive anchor; Region: Gram_pos_anchor; cl15427 889513005288 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 889513005289 active site 889513005290 catalytic site [active] 889513005291 Fibronectin type III-like domain; Region: Fn3-like; cl15273 889513005292 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 889513005293 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 889513005294 active site 889513005295 catalytic site [active] 889513005296 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 889513005297 Clp amino terminal domain; Region: Clp_N; pfam02861 889513005298 Clp amino terminal domain; Region: Clp_N; pfam02861 889513005299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513005300 Walker A motif; other site 889513005301 ATP binding site [chemical binding]; other site 889513005302 Walker B motif; other site 889513005303 arginine finger; other site 889513005304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889513005305 Walker A motif; other site 889513005306 ATP binding site [chemical binding]; other site 889513005307 Walker B motif; other site 889513005308 arginine finger; other site 889513005309 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 889513005310 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 889513005311 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889513005312 Walker A/P-loop; other site 889513005313 ATP binding site [chemical binding]; other site 889513005314 Q-loop/lid; other site 889513005315 ABC transporter signature motif; other site 889513005316 Walker B; other site 889513005317 D-loop; other site 889513005318 H-loop/switch region; other site 889513005319 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 889513005320 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 889513005321 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 889513005322 FAD binding pocket [chemical binding]; other site 889513005323 conserved FAD binding motif [chemical binding]; other site 889513005324 phosphate binding motif [ion binding]; other site 889513005325 beta-alpha-beta structure motif; other site 889513005326 NAD binding pocket [chemical binding]; other site 889513005327 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889513005328 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 889513005329 FtsX-like permease family; Region: FtsX; cl15850 889513005330 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889513005331 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889513005332 Walker A/P-loop; other site 889513005333 ATP binding site [chemical binding]; other site 889513005334 Q-loop/lid; other site 889513005335 ABC transporter signature motif; other site 889513005336 Walker B; other site 889513005337 D-loop; other site 889513005338 H-loop/switch region; other site 889513005339 macrolide transporter subunit MacA; Provisional; Region: PRK11578 889513005340 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 889513005341 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 889513005342 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 889513005343 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 889513005344 NAD binding site [chemical binding]; other site 889513005345 substrate binding site [chemical binding]; other site 889513005346 catalytic Zn binding site [ion binding]; other site 889513005347 tetramer interface [polypeptide binding]; other site 889513005348 structural Zn binding site [ion binding]; other site 889513005349 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 889513005350 active site 889513005351 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 889513005352 DNA binding residues [nucleotide binding] 889513005353 chaperone protein DnaJ; Provisional; Region: PRK14279 889513005354 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 889513005355 HSP70 interaction site [polypeptide binding]; other site 889513005356 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 889513005357 Zn binding sites [ion binding]; other site 889513005358 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 889513005359 dimer interface [polypeptide binding]; other site 889513005360 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 889513005361 dimer interface [polypeptide binding]; other site 889513005362 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 889513005363 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 889513005364 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 889513005365 active site 889513005366 catalytic site [active] 889513005367 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 889513005368 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513005369 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 889513005370 Walker A/P-loop; other site 889513005371 ATP binding site [chemical binding]; other site 889513005372 Q-loop/lid; other site 889513005373 ABC transporter signature motif; other site 889513005374 Walker B; other site 889513005375 D-loop; other site 889513005376 H-loop/switch region; other site 889513005377 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889513005378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513005379 dimer interface [polypeptide binding]; other site 889513005380 conserved gate region; other site 889513005381 putative PBP binding loops; other site 889513005382 ABC-ATPase subunit interface; other site 889513005383 Phosphate transporter family; Region: PHO4; cl00396 889513005384 Phosphate transporter family; Region: PHO4; cl00396 889513005385 adrenodoxin reductase; Provisional; Region: PTZ00188 889513005386 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 889513005387 4Fe-4S binding domain; Region: Fer4; cl02805 889513005388 Cysteine-rich domain; Region: CCG; pfam02754 889513005389 Cysteine-rich domain; Region: CCG; pfam02754 889513005390 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 889513005391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889513005392 dimerization interface [polypeptide binding]; other site 889513005393 putative DNA binding site [nucleotide binding]; other site 889513005394 putative Zn2+ binding site [ion binding]; other site 889513005395 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889513005396 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889513005397 Walker A/P-loop; other site 889513005398 ATP binding site [chemical binding]; other site 889513005399 Q-loop/lid; other site 889513005400 ABC transporter signature motif; other site 889513005401 Walker B; other site 889513005402 D-loop; other site 889513005403 H-loop/switch region; other site 889513005404 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 889513005405 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513005406 putative PBP binding regions; other site 889513005407 ABC-ATPase subunit interface; other site 889513005408 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 889513005409 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889513005410 intersubunit interface [polypeptide binding]; other site 889513005411 UreD urease accessory protein; Region: UreD; cl00530 889513005412 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889513005413 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 889513005414 UreF; Region: UreF; pfam01730 889513005415 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 889513005416 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 889513005417 dimer interface [polypeptide binding]; other site 889513005418 catalytic residues [active] 889513005419 urease subunit alpha; Reviewed; Region: ureC; PRK13207 889513005420 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 889513005421 subunit interactions [polypeptide binding]; other site 889513005422 active site 889513005423 flap region; other site 889513005424 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 889513005425 gamma-beta subunit interface [polypeptide binding]; other site 889513005426 alpha-beta subunit interface [polypeptide binding]; other site 889513005427 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 889513005428 alpha-gamma subunit interface [polypeptide binding]; other site 889513005429 beta-gamma subunit interface [polypeptide binding]; other site 889513005430 EamA-like transporter family; Region: EamA; cl01037 889513005431 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 889513005432 EamA-like transporter family; Region: EamA; cl01037 889513005433 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 889513005434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889513005435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513005436 homodimer interface [polypeptide binding]; other site 889513005437 catalytic residue [active] 889513005438 YibE/F-like protein; Region: YibE_F; cl02259 889513005439 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 889513005440 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 889513005441 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 889513005442 dimer interface [polypeptide binding]; other site 889513005443 putative anticodon binding site; other site 889513005444 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 889513005445 motif 1; other site 889513005446 dimer interface [polypeptide binding]; other site 889513005447 active site 889513005448 motif 2; other site 889513005449 motif 3; other site 889513005450 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 889513005451 Protein of unknown function (DUF998); Region: DUF998; pfam06197 889513005452 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 889513005453 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 889513005454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513005455 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 889513005456 trimer interface [polypeptide binding]; other site 889513005457 active site 889513005458 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 889513005459 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 889513005460 NAD(P) binding site [chemical binding]; other site 889513005461 catalytic residues [active] 889513005462 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 889513005463 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 889513005464 VanW like protein; Region: VanW; pfam04294 889513005465 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 889513005466 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 889513005467 OpgC protein; Region: OpgC_C; cl00792 889513005468 Acyltransferase family; Region: Acyl_transf_3; pfam01757 889513005469 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 889513005470 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889513005471 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 889513005472 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 889513005473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513005474 S-adenosylmethionine binding site [chemical binding]; other site 889513005475 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 889513005476 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 889513005477 active site 889513005478 substrate-binding site [chemical binding]; other site 889513005479 metal-binding site [ion binding] 889513005480 GTP binding site [chemical binding]; other site 889513005481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889513005482 S-adenosylmethionine binding site [chemical binding]; other site 889513005483 LabA_like proteins; Region: LabA_like; cd06167 889513005484 putative metal binding site [ion binding]; other site 889513005485 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 889513005486 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 889513005487 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 889513005488 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 889513005489 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 889513005490 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 889513005491 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889513005492 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889513005493 Phosphopantetheine attachment site; Region: PP-binding; cl09936 889513005494 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 889513005495 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 889513005496 active site 889513005497 Acyl transferase domain; Region: Acyl_transf_1; cl08282 889513005498 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 889513005499 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 889513005500 AMP-binding enzyme; Region: AMP-binding; cl15778 889513005501 Cutinase; Region: Cutinase; pfam01083 889513005502 Putative esterase; Region: Esterase; pfam00756 889513005503 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513005504 LGFP repeat; Region: LGFP; pfam08310 889513005505 LGFP repeat; Region: LGFP; pfam08310 889513005506 LGFP repeat; Region: LGFP; pfam08310 889513005507 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 889513005508 Predicted esterase [General function prediction only]; Region: COG0627 889513005509 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889513005510 UbiA prenyltransferase family; Region: UbiA; cl00337 889513005511 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 889513005512 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 889513005513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 889513005514 Repair protein; Region: Repair_PSII; cl01535 889513005515 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 889513005516 active site 889513005517 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 889513005518 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 889513005519 active site 889513005520 catalytic site [active] 889513005521 metal binding site [ion binding]; metal-binding site 889513005522 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 889513005523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513005524 putative substrate translocation pore; other site 889513005525 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 889513005526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513005527 UDP-galactopyranose mutase; Region: GLF; pfam03275 889513005528 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889513005529 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889513005530 Walker A/P-loop; other site 889513005531 ATP binding site [chemical binding]; other site 889513005532 Q-loop/lid; other site 889513005533 ABC transporter signature motif; other site 889513005534 Walker B; other site 889513005535 D-loop; other site 889513005536 H-loop/switch region; other site 889513005537 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 889513005538 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889513005539 putative PBP binding regions; other site 889513005540 ABC-ATPase subunit interface; other site 889513005541 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 889513005542 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 889513005543 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 889513005544 putative binding site residues; other site 889513005545 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 889513005546 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 889513005547 amidase catalytic site [active] 889513005548 Zn binding residues [ion binding]; other site 889513005549 substrate binding site [chemical binding]; other site 889513005550 LGFP repeat; Region: LGFP; pfam08310 889513005551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889513005552 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889513005553 active site 889513005554 motif I; other site 889513005555 motif II; other site 889513005556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889513005557 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 889513005558 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 889513005559 putative acyl-acceptor binding pocket; other site 889513005560 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 889513005561 seryl-tRNA synthetase; Provisional; Region: PRK05431 889513005562 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 889513005563 dimer interface [polypeptide binding]; other site 889513005564 active site 889513005565 motif 1; other site 889513005566 motif 2; other site 889513005567 motif 3; other site 889513005568 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889513005569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889513005570 DNA-binding site [nucleotide binding]; DNA binding site 889513005571 UTRA domain; Region: UTRA; cl01230 889513005572 Septum formation; Region: Septum_form; pfam13845 889513005573 Septum formation; Region: Septum_form; pfam13845 889513005574 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 889513005575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889513005576 catalytic core [active] 889513005577 Prephenate dehydratase; Region: PDT; pfam00800 889513005578 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 889513005579 putative L-Phe binding site [chemical binding]; other site 889513005580 Amidase; Region: Amidase; cl11426 889513005581 CAAX protease self-immunity; Region: Abi; cl00558 889513005582 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 889513005583 Htaa; Region: HtaA; pfam04213 889513005584 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 889513005585 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 889513005586 putative active site [active] 889513005587 catalytic site [active] 889513005588 putative metal binding site [ion binding]; other site 889513005589 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 889513005590 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 889513005591 Nucleoside recognition; Region: Gate; cl00486 889513005592 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 889513005593 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 889513005594 active site 889513005595 catalytic motif [active] 889513005596 Zn binding site [ion binding]; other site 889513005597 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 889513005598 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 889513005599 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 889513005600 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 889513005601 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 889513005602 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 889513005603 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889513005604 NAD binding site [chemical binding]; other site 889513005605 dimer interface [polypeptide binding]; other site 889513005606 substrate binding site [chemical binding]; other site 889513005607 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 889513005608 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 889513005609 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 889513005610 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 889513005611 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889513005612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513005613 putative substrate translocation pore; other site 889513005614 Abi-like protein; Region: Abi_2; cl01988 889513005615 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 889513005616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513005617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513005618 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 889513005619 homodimer interface [polypeptide binding]; other site 889513005620 chemical substrate binding site [chemical binding]; other site 889513005621 oligomer interface [polypeptide binding]; other site 889513005622 metal binding site [ion binding]; metal-binding site 889513005623 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 889513005624 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 889513005625 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 889513005626 Lsr2; Region: Lsr2; pfam11774 889513005627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 889513005628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889513005629 active site 889513005630 phosphorylation site [posttranslational modification] 889513005631 intermolecular recognition site; other site 889513005632 dimerization interface [polypeptide binding]; other site 889513005633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889513005634 DNA binding residues [nucleotide binding] 889513005635 dimerization interface [polypeptide binding]; other site 889513005636 Histidine kinase; Region: HisKA_3; pfam07730 889513005637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889513005638 ATP binding site [chemical binding]; other site 889513005639 Mg2+ binding site [ion binding]; other site 889513005640 G-X-G motif; other site 889513005641 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 889513005642 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 889513005643 active site 889513005644 catalytic site [active] 889513005645 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 889513005646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889513005647 Helix-turn-helix domains; Region: HTH; cl00088 889513005648 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 889513005649 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889513005650 Ligand Binding Site [chemical binding]; other site 889513005651 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889513005652 Ligand Binding Site [chemical binding]; other site 889513005653 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 889513005654 active site 889513005655 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889513005656 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889513005657 Walker A/P-loop; other site 889513005658 ATP binding site [chemical binding]; other site 889513005659 Q-loop/lid; other site 889513005660 ABC transporter signature motif; other site 889513005661 Walker B; other site 889513005662 D-loop; other site 889513005663 H-loop/switch region; other site 889513005664 Predicted transcriptional regulators [Transcription]; Region: COG1725 889513005665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889513005666 DNA-binding site [nucleotide binding]; DNA binding site 889513005667 LabA_like proteins; Region: LabA_like; cd06167 889513005668 putative metal binding site [ion binding]; other site 889513005669 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 889513005670 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889513005671 catalytic residues [active] 889513005672 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 889513005673 metal-binding site [ion binding] 889513005674 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 889513005675 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 889513005676 metal-binding site [ion binding] 889513005677 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889513005678 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889513005679 benzoate transport; Region: 2A0115; TIGR00895 889513005680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513005681 putative substrate translocation pore; other site 889513005682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889513005683 replicative DNA helicase; Provisional; Region: PRK05636 889513005684 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 889513005685 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 889513005686 Walker A motif; other site 889513005687 ATP binding site [chemical binding]; other site 889513005688 Walker B motif; other site 889513005689 DNA binding loops [nucleotide binding] 889513005690 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 889513005691 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 889513005692 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 889513005693 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 889513005694 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 889513005695 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 889513005696 dimer interface [polypeptide binding]; other site 889513005697 ssDNA binding site [nucleotide binding]; other site 889513005698 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889513005699 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 889513005700 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 889513005701 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 889513005702 Transglycosylase; Region: Transgly; cl07896 889513005703 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889513005704 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889513005705 Helix-turn-helix domains; Region: HTH; cl00088 889513005706 Helix-turn-helix domains; Region: HTH; cl00088 889513005707 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889513005708 Ligand Binding Site [chemical binding]; other site 889513005709 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889513005710 Ligand Binding Site [chemical binding]; other site 889513005711 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 889513005712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513005713 NAD(P) binding site [chemical binding]; other site 889513005714 active site 889513005715 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 889513005716 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 889513005717 active site residue [active] 889513005718 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 889513005719 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 889513005720 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 889513005721 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 889513005722 dimerization interface [polypeptide binding]; other site 889513005723 DPS ferroxidase diiron center [ion binding]; other site 889513005724 ion pore; other site 889513005725 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 889513005726 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 889513005727 putative DNA binding site [nucleotide binding]; other site 889513005728 catalytic residue [active] 889513005729 putative H2TH interface [polypeptide binding]; other site 889513005730 putative catalytic residues [active] 889513005731 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 889513005732 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 889513005733 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 889513005734 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 889513005735 putative substrate binding site [chemical binding]; other site 889513005736 putative ATP binding site [chemical binding]; other site 889513005737 VanZ like family; Region: VanZ; cl01971 889513005738 Predicted membrane protein [Function unknown]; Region: COG1511 889513005739 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 889513005740 Predicted membrane protein [Function unknown]; Region: COG1511 889513005741 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 889513005742 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 889513005743 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 889513005744 HIGH motif; other site 889513005745 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 889513005746 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889513005747 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889513005748 active site 889513005749 KMSKS motif; other site 889513005750 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 889513005751 tRNA binding surface [nucleotide binding]; other site 889513005752 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889513005753 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889513005754 Walker A/P-loop; other site 889513005755 ATP binding site [chemical binding]; other site 889513005756 Q-loop/lid; other site 889513005757 ABC transporter signature motif; other site 889513005758 Walker B; other site 889513005759 D-loop; other site 889513005760 H-loop/switch region; other site 889513005761 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889513005762 FtsX-like permease family; Region: FtsX; cl15850 889513005763 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 889513005764 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 889513005765 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 889513005766 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 889513005767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 889513005768 Histidine kinase; Region: HisKA_3; pfam07730 889513005769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 889513005770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 889513005771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889513005772 active site 889513005773 phosphorylation site [posttranslational modification] 889513005774 intermolecular recognition site; other site 889513005775 dimerization interface [polypeptide binding]; other site 889513005776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889513005777 DNA binding residues [nucleotide binding] 889513005778 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 889513005779 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 889513005780 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 889513005781 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 889513005782 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 889513005783 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 889513005784 active site 889513005785 trimer interface [polypeptide binding]; other site 889513005786 allosteric site; other site 889513005787 active site lid [active] 889513005788 hexamer (dimer of trimers) interface [polypeptide binding]; other site 889513005789 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 889513005790 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 889513005791 active site 889513005792 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 889513005793 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 889513005794 putative active site cavity [active] 889513005795 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889513005796 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889513005797 Transcriptional regulators [Transcription]; Region: FadR; COG2186 889513005798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889513005799 DNA-binding site [nucleotide binding]; DNA binding site 889513005800 FCD domain; Region: FCD; cl11656 889513005801 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 889513005802 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 889513005803 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889513005804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513005805 dimer interface [polypeptide binding]; other site 889513005806 conserved gate region; other site 889513005807 putative PBP binding loops; other site 889513005808 ABC-ATPase subunit interface; other site 889513005809 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 889513005810 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 889513005811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889513005812 dimer interface [polypeptide binding]; other site 889513005813 conserved gate region; other site 889513005814 putative PBP binding loops; other site 889513005815 ABC-ATPase subunit interface; other site 889513005816 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 889513005817 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513005818 Walker A/P-loop; other site 889513005819 ATP binding site [chemical binding]; other site 889513005820 Q-loop/lid; other site 889513005821 ABC transporter signature motif; other site 889513005822 Walker B; other site 889513005823 D-loop; other site 889513005824 H-loop/switch region; other site 889513005825 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889513005826 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 889513005827 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889513005828 Walker A/P-loop; other site 889513005829 ATP binding site [chemical binding]; other site 889513005830 Q-loop/lid; other site 889513005831 ABC transporter signature motif; other site 889513005832 Walker B; other site 889513005833 D-loop; other site 889513005834 H-loop/switch region; other site 889513005835 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889513005836 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 889513005837 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 889513005838 inhibitor site; inhibition site 889513005839 active site 889513005840 dimer interface [polypeptide binding]; other site 889513005841 catalytic residue [active] 889513005842 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 889513005843 active site 889513005844 catalytic residues [active] 889513005845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 889513005846 hypothetical protein; Provisional; Region: PRK13663 889513005847 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 889513005848 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 889513005849 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 889513005850 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 889513005851 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 889513005852 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 889513005853 substrate binding pocket [chemical binding]; other site 889513005854 substrate-Mg2+ binding site; other site 889513005855 aspartate-rich region 1; other site 889513005856 aspartate-rich region 2; other site 889513005857 phytoene desaturase; Region: crtI_fam; TIGR02734 889513005858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889513005859 SdpI/YhfL protein family; Region: SdpI; pfam13630 889513005860 anthranilate synthase component I; Provisional; Region: PRK13564 889513005861 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 889513005862 chorismate binding enzyme; Region: Chorismate_bind; cl10555 889513005863 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 889513005864 Glutamine amidotransferase class-I; Region: GATase; pfam00117 889513005865 glutamine binding [chemical binding]; other site 889513005866 catalytic triad [active] 889513005867 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 889513005868 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 889513005869 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 889513005870 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 889513005871 active site 889513005872 ribulose/triose binding site [chemical binding]; other site 889513005873 phosphate binding site [ion binding]; other site 889513005874 substrate (anthranilate) binding pocket [chemical binding]; other site 889513005875 product (indole) binding pocket [chemical binding]; other site 889513005876 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 889513005877 active site 889513005878 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 889513005879 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 889513005880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889513005881 catalytic residue [active] 889513005882 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 889513005883 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 889513005884 substrate binding site [chemical binding]; other site 889513005885 active site 889513005886 catalytic residues [active] 889513005887 heterodimer interface [polypeptide binding]; other site 889513005888 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 889513005889 iron-sulfur cluster [ion binding]; other site 889513005890 [2Fe-2S] cluster binding site [ion binding]; other site 889513005891 Membrane transport protein; Region: Mem_trans; cl09117 889513005892 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 889513005893 AzlC protein; Region: AzlC; cl00570 889513005894 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 889513005895 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 889513005896 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 889513005897 active site 889513005898 NTP binding site [chemical binding]; other site 889513005899 metal binding triad [ion binding]; metal-binding site 889513005900 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 889513005901 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889513005902 Zn2+ binding site [ion binding]; other site 889513005903 Mg2+ binding site [ion binding]; other site 889513005904 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 889513005905 active site 889513005906 Ap6A binding site [chemical binding]; other site 889513005907 nudix motif; other site 889513005908 metal binding site [ion binding]; metal-binding site 889513005909 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 889513005910 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 889513005911 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889513005912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889513005913 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 889513005914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889513005915 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889513005916 catalytic residues [active] 889513005917 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 889513005918 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 889513005919 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 889513005920 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 889513005921 active site 889513005922 metal binding site [ion binding]; metal-binding site 889513005923 ParB-like partition proteins; Region: parB_part; TIGR00180 889513005924 ParB-like nuclease domain; Region: ParBc; cl02129 889513005925 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 889513005926 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 889513005927 P-loop; other site 889513005928 Magnesium ion binding site [ion binding]; other site 889513005929 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 889513005930 Magnesium ion binding site [ion binding]; other site 889513005931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 889513005932 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 889513005933 Haemolytic domain; Region: Haemolytic; cl00506 889513005934 Ribonuclease P; Region: Ribonuclease_P; cl00457 889513005935 Ribosomal protein L34; Region: Ribosomal_L34; cl00370