-- dump date 20111121_011552 -- class Genbank::misc_feature -- table misc_feature_note -- id note 662755000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 662755000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755000003 Walker A motif; other site 662755000004 ATP binding site [chemical binding]; other site 662755000005 Walker B motif; other site 662755000006 arginine finger; other site 662755000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 662755000008 DnaA box-binding interface [nucleotide binding]; other site 662755000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 662755000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 662755000011 putative DNA binding surface [nucleotide binding]; other site 662755000012 dimer interface [polypeptide binding]; other site 662755000013 beta-clamp/clamp loader binding surface; other site 662755000014 beta-clamp/translesion DNA polymerase binding surface; other site 662755000015 recombination protein F; Reviewed; Region: recF; PRK00064 662755000016 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 662755000017 Walker A/P-loop; other site 662755000018 ATP binding site [chemical binding]; other site 662755000019 Q-loop/lid; other site 662755000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755000021 ABC transporter signature motif; other site 662755000022 Walker B; other site 662755000023 D-loop; other site 662755000024 H-loop/switch region; other site 662755000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 662755000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 662755000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 662755000028 ATP binding site [chemical binding]; other site 662755000029 Mg2+ binding site [ion binding]; other site 662755000030 G-X-G motif; other site 662755000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 662755000032 anchoring element; other site 662755000033 dimer interface [polypeptide binding]; other site 662755000034 ATP binding site [chemical binding]; other site 662755000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 662755000036 active site 662755000037 putative metal-binding site [ion binding]; other site 662755000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 662755000039 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 662755000040 DNA gyrase subunit A; Validated; Region: PRK05560 662755000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 662755000042 CAP-like domain; other site 662755000043 Active site [active] 662755000044 primary dimer interface [polypeptide binding]; other site 662755000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 662755000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 662755000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 662755000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 662755000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 662755000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 662755000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 662755000052 Domain of unknown function DUF222; Region: DUF222; pfam02720 662755000053 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 662755000054 active site 662755000055 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 662755000056 Phage integrase family; Region: Phage_integrase; pfam00589 662755000057 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 662755000058 DNA binding site [nucleotide binding] 662755000059 Int/Topo IB signature motif; other site 662755000060 active site 662755000061 putative transposase OrfB; Reviewed; Region: PHA02517 662755000062 Integrase core domain; Region: rve; cl01316 662755000063 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 662755000064 MULE transposase domain; Region: MULE; pfam10551 662755000065 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 662755000066 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755000067 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755000068 MULE transposase domain; Region: MULE; pfam10551 662755000069 AMP-binding enzyme; Region: AMP-binding; pfam00501 662755000070 potential frameshift: common BLAST hit: gi|17158096|ref|NP_478092.1| TraA protein 662755000071 TrwC relaxase; Region: TrwC; cl08490 662755000072 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 662755000073 Thymidine kinase; Region: TK; cl00631 662755000074 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 662755000075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755000076 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 662755000077 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 662755000078 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 662755000079 catalytic residue [active] 662755000080 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 662755000081 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 662755000082 dimer interface [polypeptide binding]; other site 662755000083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755000084 catalytic residue [active] 662755000085 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 662755000086 MatE; Region: MatE; cl10513 662755000087 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 662755000088 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 662755000089 putative ligand binding residues [chemical binding]; other site 662755000090 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755000091 dimer interface [polypeptide binding]; other site 662755000092 putative PBP binding regions; other site 662755000093 ABC-ATPase subunit interface; other site 662755000094 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 662755000095 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 662755000096 Walker A/P-loop; other site 662755000097 ATP binding site [chemical binding]; other site 662755000098 Q-loop/lid; other site 662755000099 ABC transporter signature motif; other site 662755000100 Walker B; other site 662755000101 D-loop; other site 662755000102 H-loop/switch region; other site 662755000103 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 662755000104 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 662755000105 NAD(P) binding site [chemical binding]; other site 662755000106 catalytic residues [active] 662755000107 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 662755000108 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 662755000109 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 662755000110 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 662755000111 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 662755000112 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 662755000113 chorismate binding enzyme; Region: Chorismate_bind; cl10555 662755000114 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 662755000115 active site 662755000116 Rhomboid family; Region: Rhomboid; cl11446 662755000117 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 662755000118 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 662755000119 Glutamine amidotransferase class-I; Region: GATase; pfam00117 662755000120 glutamine binding [chemical binding]; other site 662755000121 catalytic triad [active] 662755000122 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 662755000123 Catalytic domain of Protein Kinases; Region: PKc; cd00180 662755000124 active site 662755000125 ATP binding site [chemical binding]; other site 662755000126 substrate binding site [chemical binding]; other site 662755000127 activation loop (A-loop); other site 662755000128 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 662755000129 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 662755000130 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 662755000131 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 662755000132 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 662755000133 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 662755000134 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 662755000135 active site 662755000136 ATP binding site [chemical binding]; other site 662755000137 substrate binding site [chemical binding]; other site 662755000138 activation loop (A-loop); other site 662755000139 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 662755000140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 662755000141 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 662755000142 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 662755000143 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 662755000144 Active site [active] 662755000145 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 662755000146 phosphopeptide binding site; other site 662755000147 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 662755000148 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 662755000149 phosphopeptide binding site; other site 662755000150 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 662755000151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 662755000152 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 662755000153 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 662755000154 inhibitor-cofactor binding pocket; inhibition site 662755000155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755000156 catalytic residue [active] 662755000157 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 662755000158 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 662755000159 potential catalytic triad [active] 662755000160 conserved cys residue [active] 662755000161 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 662755000162 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 662755000163 dimer interface [polypeptide binding]; other site 662755000164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755000165 catalytic residue [active] 662755000166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 662755000167 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 662755000168 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 662755000169 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 662755000170 catalytic residue [active] 662755000171 Sulfate transporter family; Region: Sulfate_transp; cl00967 662755000172 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 662755000173 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 662755000174 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 662755000175 siderophore binding site; other site 662755000176 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755000177 dimer interface [polypeptide binding]; other site 662755000178 putative PBP binding regions; other site 662755000179 ABC-ATPase subunit interface; other site 662755000180 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755000181 ABC-ATPase subunit interface; other site 662755000182 dimer interface [polypeptide binding]; other site 662755000183 putative PBP binding regions; other site 662755000184 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 662755000185 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 662755000186 Walker A/P-loop; other site 662755000187 ATP binding site [chemical binding]; other site 662755000188 Q-loop/lid; other site 662755000189 ABC transporter signature motif; other site 662755000190 Walker B; other site 662755000191 D-loop; other site 662755000192 H-loop/switch region; other site 662755000193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755000194 DNA-binding site [nucleotide binding]; DNA binding site 662755000195 Integrase core domain; Region: rve; cl01316 662755000196 Transposase; Region: DEDD_Tnp_IS110; pfam01548 662755000197 Transposase; Region: DEDD_Tnp_IS110; pfam01548 662755000198 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 662755000199 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 662755000200 helix-hairpin-helix signature motif; other site 662755000201 active site 662755000202 MULE transposase domain; Region: MULE; pfam10551 662755000203 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755000204 putative transposase OrfB; Reviewed; Region: PHA02517 662755000205 Integrase core domain; Region: rve; cl01316 662755000206 MULE transposase domain; Region: MULE; pfam10551 662755000207 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755000208 MULE transposase domain; Region: MULE; pfam10551 662755000209 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755000210 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 662755000211 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 662755000212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755000213 homodimer interface [polypeptide binding]; other site 662755000214 catalytic residue [active] 662755000215 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 662755000216 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755000217 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 662755000218 active site 662755000219 DNA binding site [nucleotide binding] 662755000220 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 662755000221 Integrase core domain; Region: rve; cl01316 662755000222 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 662755000223 Cysteine-rich domain; Region: CCG; pfam02754 662755000224 Cysteine-rich domain; Region: CCG; pfam02754 662755000225 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 662755000226 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 662755000227 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 662755000228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755000229 dimer interface [polypeptide binding]; other site 662755000230 conserved gate region; other site 662755000231 putative PBP binding loops; other site 662755000232 ABC-ATPase subunit interface; other site 662755000233 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 662755000234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755000235 dimer interface [polypeptide binding]; other site 662755000236 conserved gate region; other site 662755000237 putative PBP binding loops; other site 662755000238 ABC-ATPase subunit interface; other site 662755000239 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 662755000240 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 662755000241 Walker A/P-loop; other site 662755000242 ATP binding site [chemical binding]; other site 662755000243 Q-loop/lid; other site 662755000244 ABC transporter signature motif; other site 662755000245 Walker B; other site 662755000246 D-loop; other site 662755000247 H-loop/switch region; other site 662755000248 Type II (General) Secretory Pathway (IISP) Family protein; Region: 3a0501s02; TIGR00960 662755000249 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 662755000250 Walker A/P-loop; other site 662755000251 ATP binding site [chemical binding]; other site 662755000252 Q-loop/lid; other site 662755000253 ABC transporter signature motif; other site 662755000254 Walker B; other site 662755000255 D-loop; other site 662755000256 H-loop/switch region; other site 662755000257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 662755000258 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 662755000259 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 662755000260 dimer interface [polypeptide binding]; other site 662755000261 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 662755000262 Integrase core domain; Region: rve; cl01316 662755000263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 662755000264 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 662755000265 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 662755000266 hinge; other site 662755000267 active site 662755000268 GAF domain; Region: GAF; cl00853 662755000269 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 662755000270 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 662755000271 DNA binding residues [nucleotide binding] 662755000272 dimerization interface [polypeptide binding]; other site 662755000273 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 662755000274 enoyl-CoA hydratase; Provisional; Region: PRK05862 662755000275 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 662755000276 substrate binding site [chemical binding]; other site 662755000277 oxyanion hole (OAH) forming residues; other site 662755000278 trimer interface [polypeptide binding]; other site 662755000279 cysteine synthases; Region: cysKM; TIGR01136 662755000280 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 662755000281 dimer interface [polypeptide binding]; other site 662755000282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755000283 catalytic residue [active] 662755000284 serine O-acetyltransferase; Region: cysE; TIGR01172 662755000285 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 662755000286 trimer interface [polypeptide binding]; other site 662755000287 active site 662755000288 substrate binding site [chemical binding]; other site 662755000289 CoA binding site [chemical binding]; other site 662755000290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755000291 MULE transposase domain; Region: MULE; pfam10551 662755000292 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755000293 PhoD-like phosphatase; Region: PhoD; pfam09423 662755000294 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 662755000295 MULE transposase domain; Region: MULE; pfam10551 662755000296 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755000297 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 662755000298 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 662755000299 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 662755000300 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 662755000301 FMN binding site [chemical binding]; other site 662755000302 active site 662755000303 catalytic residues [active] 662755000304 substrate binding site [chemical binding]; other site 662755000305 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 662755000306 PhoU domain; Region: PhoU; pfam01895 662755000307 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 662755000308 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 662755000309 ATP-binding site [chemical binding]; other site 662755000310 Gluconate-6-phosphate binding site [chemical binding]; other site 662755000311 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 662755000312 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 662755000313 Walker A/P-loop; other site 662755000314 ATP binding site [chemical binding]; other site 662755000315 Q-loop/lid; other site 662755000316 ABC transporter signature motif; other site 662755000317 Walker B; other site 662755000318 D-loop; other site 662755000319 H-loop/switch region; other site 662755000320 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 662755000321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755000322 dimer interface [polypeptide binding]; other site 662755000323 conserved gate region; other site 662755000324 putative PBP binding loops; other site 662755000325 ABC-ATPase subunit interface; other site 662755000326 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 662755000327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755000328 dimer interface [polypeptide binding]; other site 662755000329 conserved gate region; other site 662755000330 putative PBP binding loops; other site 662755000331 ABC-ATPase subunit interface; other site 662755000332 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 662755000333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755000334 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 662755000335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755000336 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 662755000337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 662755000338 DNA binding site [nucleotide binding] 662755000339 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 662755000340 heme-binding site [chemical binding]; other site 662755000341 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 662755000342 Aminotransferase class IV; Region: Aminotran_4; pfam01063 662755000343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755000344 catalytic residue [active] 662755000345 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 662755000346 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 662755000347 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 662755000348 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 662755000349 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 662755000350 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 662755000351 dimerization interface [polypeptide binding]; other site 662755000352 putative ATP binding site [chemical binding]; other site 662755000353 amidophosphoribosyltransferase; Provisional; Region: PRK07847 662755000354 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 662755000355 active site 662755000356 tetramer interface [polypeptide binding]; other site 662755000357 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 662755000358 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 662755000359 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 662755000360 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 662755000361 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 662755000362 dimerization interface [polypeptide binding]; other site 662755000363 ATP binding site [chemical binding]; other site 662755000364 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 662755000365 dimerization interface [polypeptide binding]; other site 662755000366 ATP binding site [chemical binding]; other site 662755000367 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 662755000368 putative active site [active] 662755000369 catalytic triad [active] 662755000370 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 662755000371 Predicted deacetylase [General function prediction only]; Region: COG3233 662755000372 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 662755000373 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755000374 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 662755000375 ATP binding site [chemical binding]; other site 662755000376 active site 662755000377 substrate binding site [chemical binding]; other site 662755000378 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 662755000379 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 662755000380 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 662755000381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755000382 dimer interface [polypeptide binding]; other site 662755000383 conserved gate region; other site 662755000384 putative PBP binding loops; other site 662755000385 ABC-ATPase subunit interface; other site 662755000386 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 662755000387 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 662755000388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755000389 dimer interface [polypeptide binding]; other site 662755000390 conserved gate region; other site 662755000391 putative PBP binding loops; other site 662755000392 ABC-ATPase subunit interface; other site 662755000393 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 662755000394 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 662755000395 Walker A/P-loop; other site 662755000396 ATP binding site [chemical binding]; other site 662755000397 Q-loop/lid; other site 662755000398 ABC transporter signature motif; other site 662755000399 Walker B; other site 662755000400 D-loop; other site 662755000401 H-loop/switch region; other site 662755000402 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 662755000403 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 662755000404 Walker A/P-loop; other site 662755000405 ATP binding site [chemical binding]; other site 662755000406 Q-loop/lid; other site 662755000407 ABC transporter signature motif; other site 662755000408 Walker B; other site 662755000409 D-loop; other site 662755000410 H-loop/switch region; other site 662755000411 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 662755000412 adenylosuccinate lyase; Region: purB; TIGR00928 662755000413 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 662755000414 tetramer interface [polypeptide binding]; other site 662755000415 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 662755000416 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 662755000417 putative DNA binding site [nucleotide binding]; other site 662755000418 catalytic residue [active] 662755000419 putative H2TH interface [polypeptide binding]; other site 662755000420 putative catalytic residues [active] 662755000421 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 662755000422 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 662755000423 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 662755000424 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 662755000425 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 662755000426 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 662755000427 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 662755000428 nucleotide binding site/active site [active] 662755000429 HIT family signature motif; other site 662755000430 catalytic residue [active] 662755000431 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 662755000432 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 662755000433 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 662755000434 dimerization interface [polypeptide binding]; other site 662755000435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 662755000436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 662755000437 dimer interface [polypeptide binding]; other site 662755000438 phosphorylation site [posttranslational modification] 662755000439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 662755000440 ATP binding site [chemical binding]; other site 662755000441 Mg2+ binding site [ion binding]; other site 662755000442 G-X-G motif; other site 662755000443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 662755000444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755000445 active site 662755000446 phosphorylation site [posttranslational modification] 662755000447 intermolecular recognition site; other site 662755000448 dimerization interface [polypeptide binding]; other site 662755000449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 662755000450 DNA binding site [nucleotide binding] 662755000451 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 662755000452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 662755000453 Integrase core domain; Region: rve; cl01316 662755000454 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 662755000455 Active Sites [active] 662755000456 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 662755000457 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 662755000458 Active Sites [active] 662755000459 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 662755000460 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 662755000461 CysD dimerization site [polypeptide binding]; other site 662755000462 G1 box; other site 662755000463 putative GEF interaction site [polypeptide binding]; other site 662755000464 GTP/Mg2+ binding site [chemical binding]; other site 662755000465 Switch I region; other site 662755000466 G2 box; other site 662755000467 G3 box; other site 662755000468 Switch II region; other site 662755000469 G4 box; other site 662755000470 G5 box; other site 662755000471 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 662755000472 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-...; Region: Translation_factor_III; cl02786 662755000473 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 662755000474 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 662755000475 putative active site [active] 662755000476 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and...; Region: Chelatase_Class_II; cl02784 662755000477 active site 662755000478 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 662755000479 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 662755000480 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 662755000481 Acetokinase family; Region: Acetate_kinase; cl01029 662755000482 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 662755000483 Catalytic domain of Protein Kinases; Region: PKc; cd00180 662755000484 active site 662755000485 ATP binding site [chemical binding]; other site 662755000486 substrate binding site [chemical binding]; other site 662755000487 activation loop (A-loop); other site 662755000488 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 662755000489 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 662755000490 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 662755000491 substrate binding pocket [chemical binding]; other site 662755000492 membrane-bound complex binding site; other site 662755000493 hinge residues; other site 662755000494 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 662755000495 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 662755000496 Walker A/P-loop; other site 662755000497 ATP binding site [chemical binding]; other site 662755000498 Q-loop/lid; other site 662755000499 ABC transporter signature motif; other site 662755000500 Walker B; other site 662755000501 D-loop; other site 662755000502 H-loop/switch region; other site 662755000503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755000504 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 662755000505 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 662755000506 putative active site [active] 662755000507 catalytic site [active] 662755000508 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 662755000509 putative active site [active] 662755000510 catalytic site [active] 662755000511 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 662755000512 putative catalytic site [active] 662755000513 putative metal binding site [ion binding]; other site 662755000514 putative phosphate binding site [ion binding]; other site 662755000515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755000516 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 662755000517 active site 662755000518 catalytic residues [active] 662755000519 metal binding site [ion binding]; metal-binding site 662755000520 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 662755000521 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 662755000522 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 662755000523 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 662755000524 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 662755000525 active site 662755000526 metal binding site [ion binding]; metal-binding site 662755000527 dimer interface [polypeptide binding]; other site 662755000528 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 662755000529 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 662755000530 ring oligomerisation interface [polypeptide binding]; other site 662755000531 ATP/Mg binding site [chemical binding]; other site 662755000532 stacking interactions; other site 662755000533 hinge regions; other site 662755000534 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 662755000535 Uncharacterized conserved protein [Function unknown]; Region: COG2326 662755000536 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 662755000537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755000538 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 662755000539 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755000540 Phosphopantetheine attachment site; Region: PP-binding; cl09936 662755000541 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 662755000542 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 662755000543 putative trimer interface [polypeptide binding]; other site 662755000544 putative CoA binding site [chemical binding]; other site 662755000545 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 662755000546 putative trimer interface [polypeptide binding]; other site 662755000547 putative CoA binding site [chemical binding]; other site 662755000548 Transcriptional regulators [Transcription]; Region: MarR; COG1846 662755000549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755000550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 662755000551 active site residue [active] 662755000552 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 662755000553 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 662755000554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755000555 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 662755000556 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 662755000557 dimer interface [polypeptide binding]; other site 662755000558 substrate binding site [chemical binding]; other site 662755000559 metal binding sites [ion binding]; metal-binding site 662755000560 PBP4 family; Region: PBP4; TIGR00666 662755000561 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 662755000562 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 662755000563 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 662755000564 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 662755000565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755000566 Walker A motif; other site 662755000567 ATP binding site [chemical binding]; other site 662755000568 Walker B motif; other site 662755000569 arginine finger; other site 662755000570 Peptidase family M41; Region: Peptidase_M41; pfam01434 662755000571 GTP cyclohydrolase I; Provisional; Region: PLN03044 662755000572 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 662755000573 homodecamer interface [polypeptide binding]; other site 662755000574 active site 662755000575 putative catalytic site residues [active] 662755000576 zinc binding site [ion binding]; other site 662755000577 GTP-CH-I/GFRP interaction surface; other site 662755000578 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 662755000579 dihydropteroate synthase; Region: DHPS; TIGR01496 662755000580 substrate binding pocket [chemical binding]; other site 662755000581 dimer interface [polypeptide binding]; other site 662755000582 inhibitor binding site; inhibition site 662755000583 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 662755000584 homooctamer interface [polypeptide binding]; other site 662755000585 active site 662755000586 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 662755000587 catalytic center binding site [active] 662755000588 ATP binding site [chemical binding]; other site 662755000589 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 662755000590 Uncharacterized conserved protein [Function unknown]; Region: COG5495 662755000591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755000592 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 662755000593 Pantoate-beta-alanine ligase; Region: PanC; cd00560 662755000594 pantoate--beta-alanine ligase; Region: panC; TIGR00018 662755000595 active site 662755000596 ATP-binding site [chemical binding]; other site 662755000597 pantoate-binding site; other site 662755000598 HXXH motif; other site 662755000599 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 662755000600 active site 662755000601 catalytic residues [active] 662755000602 Sodium:solute symporter family; Region: SSF; cl00456 662755000603 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 662755000604 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 662755000605 dimer interface [polypeptide binding]; other site 662755000606 active site 662755000607 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 662755000608 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 662755000609 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 662755000610 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 662755000611 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 662755000612 tetramerization interface [polypeptide binding]; other site 662755000613 active site 662755000614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755000615 Rrf2 family protein; Region: rrf2_super; TIGR00738 662755000616 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 662755000617 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 662755000618 heme-binding site [chemical binding]; other site 662755000619 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 662755000620 FAD binding pocket [chemical binding]; other site 662755000621 conserved FAD binding motif [chemical binding]; other site 662755000622 phosphate binding motif [ion binding]; other site 662755000623 beta-alpha-beta structure motif; other site 662755000624 NAD binding pocket [chemical binding]; other site 662755000625 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 662755000626 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 662755000627 dimer interface [polypeptide binding]; other site 662755000628 putative anticodon binding site; other site 662755000629 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 662755000630 motif 1; other site 662755000631 active site 662755000632 motif 2; other site 662755000633 motif 3; other site 662755000634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 662755000635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 662755000636 active site 662755000637 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 662755000638 active site 662755000639 Phosphate transporter family; Region: PHO4; cl00396 662755000640 Phosphate transporter family; Region: PHO4; cl00396 662755000641 Phosphate transporter family; Region: PHO4; cl00396 662755000642 Phosphate transporter family; Region: PHO4; cl00396 662755000643 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 662755000644 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 662755000645 dimer interface [polypeptide binding]; other site 662755000646 substrate binding site [chemical binding]; other site 662755000647 ATP binding site [chemical binding]; other site 662755000648 acyl-CoA synthetase; Provisional; Region: PRK13382 662755000649 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755000650 Clp protease ATP binding subunit; Region: clpC; CHL00095 662755000651 Clp amino terminal domain; Region: Clp_N; pfam02861 662755000652 Clp amino terminal domain; Region: Clp_N; pfam02861 662755000653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755000654 Walker A motif; other site 662755000655 ATP binding site [chemical binding]; other site 662755000656 Walker B motif; other site 662755000657 arginine finger; other site 662755000658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755000659 Walker A motif; other site 662755000660 ATP binding site [chemical binding]; other site 662755000661 Walker B motif; other site 662755000662 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 662755000663 Secretory lipase; Region: LIP; pfam03583 662755000664 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 662755000665 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 662755000666 minor groove reading motif; other site 662755000667 helix-hairpin-helix signature motif; other site 662755000668 active site 662755000669 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 662755000670 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 662755000671 active site clefts [active] 662755000672 zinc binding site [ion binding]; other site 662755000673 dimer interface [polypeptide binding]; other site 662755000674 DNA repair protein RadA; Provisional; Region: PRK11823 662755000675 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755000676 Walker A motif; other site 662755000677 ATP binding site [chemical binding]; other site 662755000678 Walker B motif; other site 662755000679 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 662755000680 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 662755000681 substrate binding site [chemical binding]; other site 662755000682 dimer interface [polypeptide binding]; other site 662755000683 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cl10030 662755000684 homotrimer interaction site [polypeptide binding]; other site 662755000685 zinc binding site [ion binding]; other site 662755000686 CDP-binding sites; other site 662755000687 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 662755000688 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755000689 Walker A/P-loop; other site 662755000690 ATP binding site [chemical binding]; other site 662755000691 Q-loop/lid; other site 662755000692 ABC transporter signature motif; other site 662755000693 Walker B; other site 662755000694 D-loop; other site 662755000695 H-loop/switch region; other site 662755000696 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 662755000697 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 662755000698 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 662755000699 active site 662755000700 HIGH motif; other site 662755000701 nucleotide binding site [chemical binding]; other site 662755000702 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 662755000703 KMSKS motif; other site 662755000704 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 662755000705 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 662755000706 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 662755000707 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 662755000708 dimer interface [polypeptide binding]; other site 662755000709 putative radical transfer pathway; other site 662755000710 diiron center [ion binding]; other site 662755000711 tyrosyl radical; other site 662755000712 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 662755000713 Htaa; Region: HtaA; pfam04213 662755000714 Htaa; Region: HtaA; pfam04213 662755000715 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 662755000716 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 662755000717 intersubunit interface [polypeptide binding]; other site 662755000718 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755000719 ABC-ATPase subunit interface; other site 662755000720 dimer interface [polypeptide binding]; other site 662755000721 putative PBP binding regions; other site 662755000722 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 662755000723 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 662755000724 Walker A/P-loop; other site 662755000725 ATP binding site [chemical binding]; other site 662755000726 Q-loop/lid; other site 662755000727 ABC transporter signature motif; other site 662755000728 Walker B; other site 662755000729 D-loop; other site 662755000730 H-loop/switch region; other site 662755000731 Htaa; Region: HtaA; pfam04213 662755000732 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 662755000733 heme binding pocket [chemical binding]; other site 662755000734 heme ligand [chemical binding]; other site 662755000735 Htaa; Region: HtaA; pfam04213 662755000736 benzoate transport; Region: 2A0115; TIGR00895 662755000737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755000738 putative substrate translocation pore; other site 662755000739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755000740 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 662755000741 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 662755000742 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 662755000743 Carboxylesterase family; Region: COesterase; pfam00135 662755000744 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755000745 substrate binding pocket [chemical binding]; other site 662755000746 catalytic triad [active] 662755000747 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 662755000748 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 662755000749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755000750 Walker A/P-loop; other site 662755000751 ATP binding site [chemical binding]; other site 662755000752 Q-loop/lid; other site 662755000753 ABC transporter signature motif; other site 662755000754 Walker B; other site 662755000755 D-loop; other site 662755000756 H-loop/switch region; other site 662755000757 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 662755000758 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 662755000759 intersubunit interface [polypeptide binding]; other site 662755000760 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 662755000761 Amino acid permease; Region: AA_permease; pfam00324 662755000762 ornithine cyclodeaminase; Validated; Region: PRK07589 662755000763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755000764 Transcriptional regulators [Transcription]; Region: PurR; COG1609 662755000765 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 662755000766 DNA binding site [nucleotide binding] 662755000767 domain linker motif; other site 662755000768 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 662755000769 putative dimerization interface [polypeptide binding]; other site 662755000770 putative ligand binding site [chemical binding]; other site 662755000771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755000772 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 662755000773 META domain; Region: META; cl01245 662755000774 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 662755000775 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 662755000776 active site 662755000777 homotetramer interface [polypeptide binding]; other site 662755000778 Uncharacterized conserved protein [Function unknown]; Region: COG2966 662755000779 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 662755000780 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 662755000781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755000782 Integrase core domain; Region: rve; cl01316 662755000783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755000784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 662755000785 Integrase core domain; Region: rve; cl01316 662755000786 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 662755000787 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 662755000788 potential frameshift: common BLAST hit: gi|30387207|ref|NP_848184.1| ResA 662755000789 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 662755000790 catalytic nucleophile [active] 662755000791 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 662755000792 catalytic residues [active] 662755000793 Alpha amylase inhibitor; Region: A_amylase_inhib; cl03178 662755000794 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 662755000795 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 662755000796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755000797 Walker A/P-loop; other site 662755000798 ATP binding site [chemical binding]; other site 662755000799 Q-loop/lid; other site 662755000800 ABC transporter signature motif; other site 662755000801 Walker B; other site 662755000802 D-loop; other site 662755000803 H-loop/switch region; other site 662755000804 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755000805 Q-loop/lid; other site 662755000806 ABC transporter signature motif; other site 662755000807 Walker B; other site 662755000808 D-loop; other site 662755000809 H-loop/switch region; other site 662755000810 DNA repair helicase rad25; Region: rad25; TIGR00603 662755000811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 662755000812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755000813 penicillin-binding protein 2; Provisional; Region: PRK10795 662755000814 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 662755000815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755000816 ATP binding site [chemical binding]; other site 662755000817 putative Mg++ binding site [ion binding]; other site 662755000818 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 662755000819 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 662755000820 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 662755000821 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 662755000822 ferredoxin-NADP+ reductase; Region: PLN02852 662755000823 hypothetical protein; Provisional; Region: PRK09897 662755000824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755000825 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 662755000826 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 662755000827 active site residue [active] 662755000828 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 662755000829 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 662755000830 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 662755000831 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 662755000832 iron-sulfur cluster [ion binding]; other site 662755000833 [2Fe-2S] cluster binding site [ion binding]; other site 662755000834 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755000835 ABC transporter signature motif; other site 662755000836 Walker B; other site 662755000837 D-loop; other site 662755000838 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 662755000839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755000840 Walker A/P-loop; other site 662755000841 ATP binding site [chemical binding]; other site 662755000842 Q-loop/lid; other site 662755000843 ABC transporter signature motif; other site 662755000844 Walker B; other site 662755000845 D-loop; other site 662755000846 Cobalt transport protein; Region: CbiQ; cl00463 662755000847 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 662755000848 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 662755000849 THF binding site; other site 662755000850 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 662755000851 substrate binding site [chemical binding]; other site 662755000852 THF binding site; other site 662755000853 zinc-binding site [ion binding]; other site 662755000854 YibE/F-like protein; Region: YibE_F; cl02259 662755000855 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 662755000856 active site 662755000857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755000858 adenylosuccinate synthetase; Provisional; Region: PRK01117 662755000859 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 662755000860 GDP-binding site [chemical binding]; other site 662755000861 ACT binding site; other site 662755000862 IMP binding site; other site 662755000863 Predicted membrane protein [Function unknown]; Region: COG4129 662755000864 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 662755000865 putative catalytic site [active] 662755000866 putative metal binding site [ion binding]; other site 662755000867 putative phosphate binding site [ion binding]; other site 662755000868 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 662755000869 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 662755000870 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 662755000871 active site 662755000872 intersubunit interface [polypeptide binding]; other site 662755000873 zinc binding site [ion binding]; other site 662755000874 Na+ binding site [ion binding]; other site 662755000875 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 662755000876 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 662755000877 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 662755000878 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 662755000879 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 662755000880 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 662755000881 lipoyl attachment site [posttranslational modification]; other site 662755000882 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 662755000883 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 662755000884 glycine dehydrogenase; Provisional; Region: PRK05367 662755000885 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 662755000886 tetramer interface [polypeptide binding]; other site 662755000887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755000888 catalytic residue [active] 662755000889 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 662755000890 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 662755000891 catalytic residue [active] 662755000892 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 662755000893 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 662755000894 NADP binding site [chemical binding]; other site 662755000895 active site 662755000896 steroid binding site; other site 662755000897 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 662755000898 HPr interaction site; other site 662755000899 glycerol kinase (GK) interaction site [polypeptide binding]; other site 662755000900 active site 662755000901 phosphorylation site [posttranslational modification] 662755000902 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 662755000903 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 662755000904 active site residue [active] 662755000905 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 662755000906 active site residue [active] 662755000907 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 662755000908 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 662755000909 NAD(P) binding site [chemical binding]; other site 662755000910 catalytic residues [active] 662755000911 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 662755000912 Clp amino terminal domain; Region: Clp_N; pfam02861 662755000913 Clp amino terminal domain; Region: Clp_N; pfam02861 662755000914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755000915 Walker A motif; other site 662755000916 ATP binding site [chemical binding]; other site 662755000917 Walker B motif; other site 662755000918 arginine finger; other site 662755000919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755000920 Walker A motif; other site 662755000921 ATP binding site [chemical binding]; other site 662755000922 Walker B motif; other site 662755000923 arginine finger; other site 662755000924 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 662755000925 acyl-coenzyme A oxidase; Region: PLN02526 662755000926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 662755000927 active site 662755000928 Predicted amidohydrolase [General function prediction only]; Region: COG0388 662755000929 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 662755000930 putative active site [active] 662755000931 catalytic triad [active] 662755000932 putative dimer interface [polypeptide binding]; other site 662755000933 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 662755000934 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 662755000935 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 662755000936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755000937 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 662755000938 DNA binding residues [nucleotide binding] 662755000939 putative dimer interface [polypeptide binding]; other site 662755000940 chaperone protein DnaJ; Provisional; Region: PRK14279 662755000941 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 662755000942 HSP70 interaction site [polypeptide binding]; other site 662755000943 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 662755000944 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 662755000945 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 662755000946 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 662755000947 active site 662755000948 Integrase core domain; Region: rve; cl01316 662755000949 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 662755000950 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 662755000951 Walker A/P-loop; other site 662755000952 ATP binding site [chemical binding]; other site 662755000953 Q-loop/lid; other site 662755000954 ABC transporter signature motif; other site 662755000955 Walker B; other site 662755000956 D-loop; other site 662755000957 H-loop/switch region; other site 662755000958 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 662755000959 FtsX-like permease family; Region: FtsX; pfam02687 662755000960 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 662755000961 FtsX-like permease family; Region: FtsX; pfam02687 662755000962 Transcriptional regulators [Transcription]; Region: FadR; COG2186 662755000963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 662755000964 DNA-binding site [nucleotide binding]; DNA binding site 662755000965 FCD domain; Region: FCD; cl11656 662755000966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755000967 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 662755000968 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 662755000969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755000970 nucleotide binding region [chemical binding]; other site 662755000971 ATP-binding site [chemical binding]; other site 662755000972 MULE transposase domain; Region: MULE; pfam10551 662755000973 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755000974 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 662755000975 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 662755000976 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 662755000977 DNA-binding site [nucleotide binding]; DNA binding site 662755000978 RNA-binding motif; other site 662755000979 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 662755000980 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 662755000981 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 662755000982 Sulfate transporter family; Region: Sulfate_transp; cl00967 662755000983 Permease family; Region: Xan_ur_permease; pfam00860 662755000984 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 662755000985 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 662755000986 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 662755000987 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 662755000988 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 662755000989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 662755000990 catalytic residue [active] 662755000991 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 662755000992 dimer interface [polypeptide binding]; other site 662755000993 Citrate synthase; Region: Citrate_synt; pfam00285 662755000994 active site 662755000995 citrylCoA binding site [chemical binding]; other site 662755000996 NADH binding [chemical binding]; other site 662755000997 cationic pore residues; other site 662755000998 oxalacetate/citrate binding site [chemical binding]; other site 662755000999 coenzyme A binding site [chemical binding]; other site 662755001000 catalytic triad [active] 662755001001 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 662755001002 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 662755001003 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 662755001004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755001005 Walker A/P-loop; other site 662755001006 ATP binding site [chemical binding]; other site 662755001007 Q-loop/lid; other site 662755001008 ABC transporter signature motif; other site 662755001009 Walker B; other site 662755001010 D-loop; other site 662755001011 H-loop/switch region; other site 662755001012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 662755001013 non-specific DNA binding site [nucleotide binding]; other site 662755001014 salt bridge; other site 662755001015 sequence-specific DNA binding site [nucleotide binding]; other site 662755001016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 662755001017 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 662755001018 active site 662755001019 catalytic tetrad [active] 662755001020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 662755001021 enoyl-CoA hydratase; Provisional; Region: PRK07854 662755001022 substrate binding site [chemical binding]; other site 662755001023 oxyanion hole (OAH) forming residues; other site 662755001024 trimer interface [polypeptide binding]; other site 662755001025 Transposase; Region: DEDD_Tnp_IS110; pfam01548 662755001026 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 662755001027 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755001028 Walker A/P-loop; other site 662755001029 ATP binding site [chemical binding]; other site 662755001030 Q-loop/lid; other site 662755001031 ABC transporter signature motif; other site 662755001032 Walker B; other site 662755001033 D-loop; other site 662755001034 H-loop/switch region; other site 662755001035 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 662755001036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755001037 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 662755001038 Walker A/P-loop; other site 662755001039 ATP binding site [chemical binding]; other site 662755001040 Q-loop/lid; other site 662755001041 ABC transporter signature motif; other site 662755001042 Walker B; other site 662755001043 D-loop; other site 662755001044 H-loop/switch region; other site 662755001045 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 662755001046 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 662755001047 Walker A/P-loop; other site 662755001048 ATP binding site [chemical binding]; other site 662755001049 Q-loop/lid; other site 662755001050 ABC transporter signature motif; other site 662755001051 Walker B; other site 662755001052 D-loop; other site 662755001053 H-loop/switch region; other site 662755001054 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755001055 Walker A/P-loop; other site 662755001056 ATP binding site [chemical binding]; other site 662755001057 Q-loop/lid; other site 662755001058 ABC transporter signature motif; other site 662755001059 Walker B; other site 662755001060 D-loop; other site 662755001061 H-loop/switch region; other site 662755001062 Cobalt transport protein; Region: CbiQ; cl00463 662755001063 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 662755001064 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 662755001065 Sodium:solute symporter family; Region: SSF; cl00456 662755001066 Protein of unknown function, DUF485; Region: DUF485; cl01231 662755001067 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 662755001068 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 662755001069 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 662755001070 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 662755001071 folate binding site [chemical binding]; other site 662755001072 NADP+ binding site [chemical binding]; other site 662755001073 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 662755001074 dimerization interface [polypeptide binding]; other site 662755001075 active site 662755001076 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 662755001077 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 662755001078 active site 662755001079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755001080 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 662755001081 ATP binding site [chemical binding]; other site 662755001082 putative Mg++ binding site [ion binding]; other site 662755001083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755001084 nucleotide binding region [chemical binding]; other site 662755001085 ATP-binding site [chemical binding]; other site 662755001086 DEAD/H associated; Region: DEAD_assoc; pfam08494 662755001087 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 662755001088 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 662755001089 putative DNA binding site [nucleotide binding]; other site 662755001090 catalytic residue [active] 662755001091 putative H2TH interface [polypeptide binding]; other site 662755001092 putative catalytic residues [active] 662755001093 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 662755001094 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 662755001095 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 662755001096 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 662755001097 active site 662755001098 dimer interface [polypeptide binding]; other site 662755001099 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 662755001100 dimer interface [polypeptide binding]; other site 662755001101 active site 662755001102 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 662755001103 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 662755001104 tetramerization interface [polypeptide binding]; other site 662755001105 NAD(P) binding site [chemical binding]; other site 662755001106 catalytic residues [active] 662755001107 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 662755001108 sec-independent translocase; Provisional; Region: PRK00708 662755001109 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 662755001110 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 662755001111 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 662755001112 catalytic triad [active] 662755001113 catalytic triad [active] 662755001114 oxyanion hole [active] 662755001115 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 662755001116 active site 662755001117 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 662755001118 active site 662755001119 peptide chain release factor 2; Validated; Region: prfB; PRK00578 662755001120 RF-1 domain; Region: RF-1; cl02875 662755001121 RF-1 domain; Region: RF-1; cl02875 662755001122 Proline dehydrogenase; Region: Pro_dh; cl03282 662755001123 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 662755001124 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 662755001125 Glutamate binding site [chemical binding]; other site 662755001126 NAD binding site [chemical binding]; other site 662755001127 catalytic residues [active] 662755001128 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 662755001129 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 662755001130 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 662755001131 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755001132 Walker A/P-loop; other site 662755001133 ATP binding site [chemical binding]; other site 662755001134 Q-loop/lid; other site 662755001135 ABC transporter signature motif; other site 662755001136 Walker B; other site 662755001137 D-loop; other site 662755001138 H-loop/switch region; other site 662755001139 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 662755001140 FtsX-like permease family; Region: FtsX; pfam02687 662755001141 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 662755001142 SmpB-tmRNA interface; other site 662755001143 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 662755001144 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 662755001145 Walker A/P-loop; other site 662755001146 ATP binding site [chemical binding]; other site 662755001147 Q-loop/lid; other site 662755001148 ABC transporter signature motif; other site 662755001149 Walker B; other site 662755001150 D-loop; other site 662755001151 H-loop/switch region; other site 662755001152 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 662755001153 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755001154 ABC-ATPase subunit interface; other site 662755001155 dimer interface [polypeptide binding]; other site 662755001156 putative PBP binding regions; other site 662755001157 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755001158 ABC-ATPase subunit interface; other site 662755001159 dimer interface [polypeptide binding]; other site 662755001160 putative PBP binding regions; other site 662755001161 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 662755001162 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 662755001163 intersubunit interface [polypeptide binding]; other site 662755001164 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 662755001165 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 662755001166 FAD binding pocket [chemical binding]; other site 662755001167 FAD binding motif [chemical binding]; other site 662755001168 phosphate binding motif [ion binding]; other site 662755001169 NAD binding pocket [chemical binding]; other site 662755001170 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 662755001171 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 662755001172 active site 662755001173 substrate binding site [chemical binding]; other site 662755001174 metal binding site [ion binding]; metal-binding site 662755001175 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 662755001176 intersubunit interface [polypeptide binding]; other site 662755001177 active site 662755001178 catalytic residue [active] 662755001179 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 662755001180 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755001181 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 662755001182 phosphoglucomutase; Validated; Region: PRK07564 662755001183 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757 662755001184 active site 662755001185 substrate binding site [chemical binding]; other site 662755001186 metal binding site [ion binding]; metal-binding site 662755001187 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 662755001188 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 662755001189 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 662755001190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 662755001191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 662755001192 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 662755001193 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 662755001194 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 662755001195 putative active site [active] 662755001196 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 662755001197 G1 box; other site 662755001198 GTP/Mg2+ binding site [chemical binding]; other site 662755001199 Switch I region; other site 662755001200 G2 box; other site 662755001201 Switch II region; other site 662755001202 G3 box; other site 662755001203 G4 box; other site 662755001204 hypothetical protein; Provisional; Region: PRK12705 662755001205 G5 box; other site 662755001206 Predicted GTPases [General function prediction only]; Region: COG1160 662755001207 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 662755001208 G1 box; other site 662755001209 GTP/Mg2+ binding site [chemical binding]; other site 662755001210 Switch I region; other site 662755001211 G2 box; other site 662755001212 Switch II region; other site 662755001213 G3 box; other site 662755001214 G4 box; other site 662755001215 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 662755001216 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 662755001217 active site 662755001218 catalytic site [active] 662755001219 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 662755001220 active site 662755001221 catalytic site [active] 662755001222 Vitamin K epoxide reductase family; Region: VKOR; cl01729 662755001223 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 662755001224 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 662755001225 homodimer interface [polypeptide binding]; other site 662755001226 NAD binding pocket [chemical binding]; other site 662755001227 ATP binding pocket [chemical binding]; other site 662755001228 Mg binding site [ion binding]; other site 662755001229 active-site loop [active] 662755001230 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 662755001231 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 662755001232 catalytic residues [active] 662755001233 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 662755001234 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 662755001235 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 662755001236 Class I ribonucleotide reductase; Region: RNR_I; cd01679 662755001237 active site 662755001238 dimer interface [polypeptide binding]; other site 662755001239 catalytic residues [active] 662755001240 effector binding site; other site 662755001241 R2 peptide binding site; other site 662755001242 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 662755001243 Ferritin-like domain; Region: Ferritin; pfam00210 662755001244 ferroxidase diiron center [ion binding]; other site 662755001245 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 662755001246 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 662755001247 dimer interface [polypeptide binding]; other site 662755001248 putative radical transfer pathway; other site 662755001249 diiron center [ion binding]; other site 662755001250 tyrosyl radical; other site 662755001251 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 662755001252 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 662755001253 D-pathway; other site 662755001254 Putative ubiquinol binding site [chemical binding]; other site 662755001255 Low-spin heme (heme b) binding site [chemical binding]; other site 662755001256 Putative water exit pathway; other site 662755001257 Binuclear center (heme o3/CuB) [ion binding]; other site 662755001258 K-pathway; other site 662755001259 Putative proton exit pathway; other site 662755001260 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 662755001261 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 662755001262 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 662755001263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 662755001264 motif II; other site 662755001265 4-coumarate--CoA ligase; Region: PLN02246 662755001266 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755001267 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 662755001268 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 662755001269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 662755001270 DNA binding residues [nucleotide binding] 662755001271 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 662755001272 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 662755001273 Predicted GTPases [General function prediction only]; Region: COG1160 662755001274 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 662755001275 G1 box; other site 662755001276 GTP/Mg2+ binding site [chemical binding]; other site 662755001277 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 662755001278 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 662755001279 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755001280 DEAD_2; Region: DEAD_2; cl14887 662755001281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755001282 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 662755001283 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 662755001284 active site 662755001285 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 662755001286 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 662755001287 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 662755001288 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 662755001289 cleavage site 662755001290 Rhomboid family; Region: Rhomboid; cl11446 662755001291 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 662755001292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 662755001293 ribonuclease PH; Reviewed; Region: rph; PRK00173 662755001294 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 662755001295 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 662755001296 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 662755001297 dimerization interface [polypeptide binding]; other site 662755001298 active site 662755001299 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 662755001300 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 662755001301 metal binding site [ion binding]; metal-binding site 662755001302 putative dimer interface [polypeptide binding]; other site 662755001303 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 662755001304 Glucitol operon activator protein (GutM); Region: GutM; cl01890 662755001305 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 662755001306 catalytic triad [active] 662755001307 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 662755001308 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 662755001309 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 662755001310 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 662755001311 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 662755001312 Transposase; Region: DEDD_Tnp_IS110; pfam01548 662755001313 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 662755001314 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 662755001315 helix-hairpin-helix signature motif; other site 662755001316 active site 662755001317 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 662755001318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755001319 active site 662755001320 phosphorylation site [posttranslational modification] 662755001321 intermolecular recognition site; other site 662755001322 dimerization interface [polypeptide binding]; other site 662755001323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 662755001324 DNA binding residues [nucleotide binding] 662755001325 dimerization interface [polypeptide binding]; other site 662755001326 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 662755001327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 662755001328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755001329 active site 662755001330 phosphorylation site [posttranslational modification] 662755001331 intermolecular recognition site; other site 662755001332 dimerization interface [polypeptide binding]; other site 662755001333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 662755001334 DNA binding residues [nucleotide binding] 662755001335 dimerization interface [polypeptide binding]; other site 662755001336 Histidine kinase; Region: HisKA_3; pfam07730 662755001337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 662755001338 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755001339 IucA / IucC family; Region: IucA_IucC; pfam04183 662755001340 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 662755001341 IucA / IucC family; Region: IucA_IucC; pfam04183 662755001342 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 662755001343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755001344 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 662755001345 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 662755001346 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 662755001347 CoenzymeA binding site [chemical binding]; other site 662755001348 subunit interaction site [polypeptide binding]; other site 662755001349 PHB binding site; other site 662755001350 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 662755001351 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 662755001352 siderophore binding site; other site 662755001353 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 662755001354 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 662755001355 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 662755001356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 662755001357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 662755001358 LGFP repeat; Region: LGFP; pfam08310 662755001359 LGFP repeat; Region: LGFP; pfam08310 662755001360 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 662755001361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755001362 Walker A/P-loop; other site 662755001363 ATP binding site [chemical binding]; other site 662755001364 Q-loop/lid; other site 662755001365 ABC transporter signature motif; other site 662755001366 Walker B; other site 662755001367 D-loop; other site 662755001368 H-loop/switch region; other site 662755001369 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 662755001370 cystathionine gamma-synthase; Provisional; Region: PRK07811 662755001371 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 662755001372 homodimer interface [polypeptide binding]; other site 662755001373 substrate-cofactor binding pocket; other site 662755001374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755001375 catalytic residue [active] 662755001376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001377 NAD(P) binding site [chemical binding]; other site 662755001378 active site 662755001379 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 662755001380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 662755001381 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 662755001382 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 662755001383 putative active site [active] 662755001384 putative metal binding site [ion binding]; other site 662755001385 Domain of unknown function (DUF74); Region: DUF74; cl00426 662755001386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755001387 ATP binding site [chemical binding]; other site 662755001388 putative Mg++ binding site [ion binding]; other site 662755001389 Z1 domain; Region: Z1; pfam10593 662755001390 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 662755001391 putative active site [active] 662755001392 catalytic site [active] 662755001393 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 662755001394 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 662755001395 cofactor binding site; other site 662755001396 DNA binding site [nucleotide binding] 662755001397 substrate interaction site [chemical binding]; other site 662755001398 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 662755001399 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 662755001400 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 662755001401 Nitronate monooxygenase; Region: NMO; pfam03060 662755001402 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 662755001403 FMN binding site [chemical binding]; other site 662755001404 substrate binding site [chemical binding]; other site 662755001405 putative catalytic residue [active] 662755001406 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755001407 ATP binding site [chemical binding]; other site 662755001408 putative Mg++ binding site [ion binding]; other site 662755001409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755001410 nucleotide binding region [chemical binding]; other site 662755001411 ATP-binding site [chemical binding]; other site 662755001412 Helicase associated domain (HA2); Region: HA2; cl04503 662755001413 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 662755001414 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 662755001415 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 662755001416 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 662755001417 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 662755001418 active site 662755001419 FMN binding site [chemical binding]; other site 662755001420 2,4-decadienoyl-CoA binding site; other site 662755001421 catalytic residue [active] 662755001422 4Fe-4S cluster binding site [ion binding]; other site 662755001423 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 662755001424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001425 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 662755001426 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 662755001427 active site 662755001428 dimer interface [polypeptide binding]; other site 662755001429 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 662755001430 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 662755001431 active site 662755001432 FMN binding site [chemical binding]; other site 662755001433 substrate binding site [chemical binding]; other site 662755001434 3Fe-4S cluster binding site [ion binding]; other site 662755001435 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 662755001436 domain interface; other site 662755001437 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 662755001438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001439 LysE type translocator; Region: LysE; cl00565 662755001440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 662755001441 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 662755001442 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 662755001443 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 662755001444 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 662755001445 active site 662755001446 Zn binding site [ion binding]; other site 662755001447 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 662755001448 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 662755001449 active site 662755001450 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 662755001451 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 662755001452 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 662755001453 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 662755001454 putative metal binding site [ion binding]; other site 662755001455 Predicted transcriptional regulators [Transcription]; Region: COG1725 662755001456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 662755001457 DNA-binding site [nucleotide binding]; DNA binding site 662755001458 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 662755001459 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 662755001460 Walker A/P-loop; other site 662755001461 ATP binding site [chemical binding]; other site 662755001462 Q-loop/lid; other site 662755001463 ABC transporter signature motif; other site 662755001464 Walker B; other site 662755001465 D-loop; other site 662755001466 H-loop/switch region; other site 662755001467 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 662755001468 active site 662755001469 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 662755001470 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 662755001471 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 662755001472 Ligand Binding Site [chemical binding]; other site 662755001473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 662755001474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 662755001475 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 662755001476 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 662755001477 active site 662755001478 catalytic site [active] 662755001479 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 662755001480 Lsr2; Region: Lsr2; pfam11774 662755001481 PhoD-like phosphatase; Region: PhoD; pfam09423 662755001482 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 662755001483 putative active site [active] 662755001484 putative metal binding site [ion binding]; other site 662755001485 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 662755001486 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 662755001487 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 662755001488 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 662755001489 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 662755001490 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 662755001491 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 662755001492 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 662755001493 NAD binding site [chemical binding]; other site 662755001494 dimer interface [polypeptide binding]; other site 662755001495 tetramer (dimer of dimers) interface [polypeptide binding]; other site 662755001496 substrate binding site [chemical binding]; other site 662755001497 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 662755001498 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 662755001499 active site 662755001500 nucleophile elbow; other site 662755001501 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 662755001502 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 662755001503 active site 662755001504 catalytic site [active] 662755001505 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 662755001506 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 662755001507 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 662755001508 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 662755001509 prephenate dehydratase; Provisional; Region: PRK11898 662755001510 Prephenate dehydratase; Region: PDT; pfam00800 662755001511 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 662755001512 putative L-Phe binding site [chemical binding]; other site 662755001513 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 662755001514 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 662755001515 catalytic core [active] 662755001516 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 662755001517 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 662755001518 seryl-tRNA synthetase; Provisional; Region: PRK05431 662755001519 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 662755001520 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 662755001521 dimer interface [polypeptide binding]; other site 662755001522 active site 662755001523 motif 1; other site 662755001524 motif 2; other site 662755001525 motif 3; other site 662755001526 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 662755001527 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 662755001528 putative acyl-acceptor binding pocket; other site 662755001529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 662755001530 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 662755001531 active site 662755001532 motif I; other site 662755001533 motif II; other site 662755001534 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755001535 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 662755001536 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 662755001537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001539 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 662755001540 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 662755001541 active site 662755001542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 662755001543 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 662755001544 active site 662755001545 UbiA prenyltransferase family; Region: UbiA; cl00337 662755001546 Predicted esterase [General function prediction only]; Region: COG0627 662755001547 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755001548 Putative esterase; Region: Esterase; pfam00756 662755001549 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755001550 LGFP repeat; Region: LGFP; pfam08310 662755001551 LGFP repeat; Region: LGFP; pfam08310 662755001552 LGFP repeat; Region: LGFP; pfam08310 662755001553 Cutinase; Region: Cutinase; pfam01083 662755001554 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 662755001555 Phosphopantetheine attachment site; Region: PP-binding; cl09936 662755001556 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 662755001557 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 662755001558 active site 662755001559 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 662755001560 Acyl transferase domain; Region: Acyl_transf_1; cl08282 662755001561 Phosphopantetheine attachment site; Region: PP-binding; cl09936 662755001562 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 662755001563 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 662755001564 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 662755001565 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 662755001566 acyl-CoA synthetase; Validated; Region: PRK07788 662755001567 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755001568 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 662755001569 active site 662755001570 catalytic triad [active] 662755001571 oxyanion hole [active] 662755001572 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 662755001573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755001574 putative substrate translocation pore; other site 662755001575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 662755001576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755001577 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 662755001578 putative dimerization interface [polypeptide binding]; other site 662755001579 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 662755001580 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 662755001581 Predicted integral membrane protein [Function unknown]; Region: COG0392 662755001582 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 662755001583 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 662755001584 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 662755001585 putative metal binding site [ion binding]; other site 662755001586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755001587 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 662755001588 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 662755001589 active site 662755001590 substrate-binding site [chemical binding]; other site 662755001591 metal-binding site [ion binding] 662755001592 GTP binding site [chemical binding]; other site 662755001593 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 662755001594 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 662755001595 catalytic residue [active] 662755001596 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 662755001597 catalytic residues [active] 662755001598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001599 peroxiredoxin; Region: AhpC; TIGR03137 662755001600 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 662755001601 dimer interface [polypeptide binding]; other site 662755001602 decamer (pentamer of dimers) interface [polypeptide binding]; other site 662755001603 catalytic triad [active] 662755001604 peroxidatic and resolving cysteines [active] 662755001605 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 662755001606 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 662755001607 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 662755001608 CPxP motif; other site 662755001609 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 662755001610 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 662755001611 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 662755001612 substrate binding site [chemical binding]; other site 662755001613 oxyanion hole (OAH) forming residues; other site 662755001614 trimer interface [polypeptide binding]; other site 662755001615 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 662755001616 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 662755001617 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 662755001618 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 662755001619 dimer interface [polypeptide binding]; other site 662755001620 active site 662755001621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 662755001622 S-adenosylmethionine binding site [chemical binding]; other site 662755001623 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 662755001624 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 662755001625 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 662755001626 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 662755001627 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 662755001628 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 662755001629 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 662755001630 Ligand Binding Site [chemical binding]; other site 662755001631 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 662755001632 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 662755001633 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 662755001634 VanW like protein; Region: VanW; pfam04294 662755001635 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 662755001636 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 662755001637 Integrase core domain; Region: rve; cl01316 662755001638 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 662755001639 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 662755001640 Walker A/P-loop; other site 662755001641 ATP binding site [chemical binding]; other site 662755001642 Q-loop/lid; other site 662755001643 ABC transporter signature motif; other site 662755001644 Walker B; other site 662755001645 D-loop; other site 662755001646 H-loop/switch region; other site 662755001647 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 662755001648 active site 662755001649 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 662755001650 homodimer interface [polypeptide binding]; other site 662755001651 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 662755001652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 662755001653 active site 662755001654 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 662755001655 ABC-2 type transporter; Region: ABC2_membrane; cl11417 662755001656 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 662755001657 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 662755001658 Walker A/P-loop; other site 662755001659 ATP binding site [chemical binding]; other site 662755001660 Q-loop/lid; other site 662755001661 ABC transporter signature motif; other site 662755001662 Walker B; other site 662755001663 D-loop; other site 662755001664 H-loop/switch region; other site 662755001665 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 662755001666 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 662755001667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001668 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 662755001669 active site 662755001670 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 662755001671 active site 662755001672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 662755001673 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 662755001674 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 662755001675 active site 662755001676 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 662755001677 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 662755001678 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 662755001679 active site 662755001680 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 662755001681 trimer interface [polypeptide binding]; other site 662755001682 active site 662755001683 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 662755001684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001685 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 662755001686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001687 Fic family protein [Function unknown]; Region: COG3177 662755001688 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 662755001689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001690 NAD(P) binding site [chemical binding]; other site 662755001691 active site 662755001692 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 662755001693 MULE transposase domain; Region: MULE; pfam10551 662755001694 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755001695 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 662755001696 Integrase core domain; Region: rve; cl01316 662755001697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 662755001698 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 662755001699 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 662755001700 substrate binding pocket [chemical binding]; other site 662755001701 substrate-Mg2+ binding site; other site 662755001702 aspartate-rich region 1; other site 662755001703 aspartate-rich region 2; other site 662755001704 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 662755001705 metal-binding site [ion binding] 662755001706 Flavin Reductases; Region: FlaRed; cl00801 662755001707 Predicted membrane protein [Function unknown]; Region: COG1470 662755001708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755001709 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 662755001710 putative active site [active] 662755001711 putative substrate binding site [chemical binding]; other site 662755001712 catalytic site [active] 662755001713 dimer interface [polypeptide binding]; other site 662755001714 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 662755001715 classical (c) SDRs; Region: SDR_c; cd05233 662755001716 NAD(P) binding site [chemical binding]; other site 662755001717 active site 662755001718 Copper resistance protein D; Region: CopD; cl00563 662755001719 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 662755001720 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 662755001721 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755001722 Walker A/P-loop; other site 662755001723 ATP binding site [chemical binding]; other site 662755001724 Q-loop/lid; other site 662755001725 ABC transporter signature motif; other site 662755001726 Walker B; other site 662755001727 D-loop; other site 662755001728 H-loop/switch region; other site 662755001729 ABC transporter; Region: ABC_tran_2; pfam12848 662755001730 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 662755001731 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 662755001732 Integrase core domain; Region: rve; cl01316 662755001733 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 662755001734 active site 662755001735 putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional; Region: PRK12775 662755001736 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 662755001737 apolar tunnel; other site 662755001738 heme binding site [chemical binding]; other site 662755001739 dimerization interface [polypeptide binding]; other site 662755001740 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 662755001741 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 662755001742 Zn binding site [ion binding]; other site 662755001743 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 662755001744 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 662755001745 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 662755001746 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 662755001747 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 662755001748 MULE transposase domain; Region: MULE; pfam10551 662755001749 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755001750 trigger factor; Provisional; Region: tig; PRK01490 662755001751 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 662755001752 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 662755001753 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 662755001754 oligomer interface [polypeptide binding]; other site 662755001755 active site residues [active] 662755001756 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 662755001757 oligomer interface [polypeptide binding]; other site 662755001758 active site residues [active] 662755001759 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 662755001760 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 662755001761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755001762 Walker A motif; other site 662755001763 ATP binding site [chemical binding]; other site 662755001764 Walker B motif; other site 662755001765 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 662755001766 malate dehydrogenase; Provisional; Region: PRK05442 662755001767 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 662755001768 NAD(P) binding site [chemical binding]; other site 662755001769 dimer interface [polypeptide binding]; other site 662755001770 malate binding site [chemical binding]; other site 662755001771 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755001772 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 662755001773 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 662755001774 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 662755001775 active site 662755001776 HIGH motif; other site 662755001777 nucleotide binding site [chemical binding]; other site 662755001778 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 662755001779 active site 662755001780 KMSKS motif; other site 662755001781 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 662755001782 tRNA binding surface [nucleotide binding]; other site 662755001783 anticodon binding site; other site 662755001784 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 662755001785 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 662755001786 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 662755001787 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 662755001788 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 662755001789 active site 662755001790 multimer interface [polypeptide binding]; other site 662755001791 MULE transposase domain; Region: MULE; pfam10551 662755001792 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755001793 translation initiation factor IF-2; Validated; Region: infB; PRK05306 662755001794 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 662755001795 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 662755001796 homodimer interface [polypeptide binding]; other site 662755001797 oligonucleotide binding site [chemical binding]; other site 662755001798 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 662755001799 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 662755001800 GTPase CgtA; Reviewed; Region: obgE; PRK12296 662755001801 GTP1/OBG; Region: GTP1_OBG; pfam01018 662755001802 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 662755001803 G1 box; other site 662755001804 GTP/Mg2+ binding site [chemical binding]; other site 662755001805 Switch I region; other site 662755001806 G2 box; other site 662755001807 G3 box; other site 662755001808 Switch II region; other site 662755001809 G4 box; other site 662755001810 G5 box; other site 662755001811 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 662755001812 gamma-glutamyl kinase; Provisional; Region: PRK05429 662755001813 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 662755001814 nucleotide binding site [chemical binding]; other site 662755001815 homotetrameric interface [polypeptide binding]; other site 662755001816 putative phosphate binding site [ion binding]; other site 662755001817 putative allosteric binding site; other site 662755001818 PUA domain; Region: PUA; cl00607 662755001819 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 662755001820 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 662755001821 putative catalytic cysteine [active] 662755001822 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 662755001823 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 662755001824 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 662755001825 active site 662755001826 (T/H)XGH motif; other site 662755001827 Domain of unknown function DUF143; Region: DUF143; cl00519 662755001828 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 662755001829 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 662755001830 catalytic core [active] 662755001831 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 662755001832 SLBB domain; Region: SLBB; pfam10531 662755001833 comEA protein; Region: comE; TIGR01259 662755001834 Competence protein; Region: Competence; cl00471 662755001835 hypothetical protein; Validated; Region: PRK05629 662755001836 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 662755001837 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 662755001838 PemK-like protein; Region: PemK; cl00995 662755001839 GTP-binding protein LepA; Provisional; Region: PRK05433 662755001840 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 662755001841 G1 box; other site 662755001842 putative GEF interaction site [polypeptide binding]; other site 662755001843 GTP/Mg2+ binding site [chemical binding]; other site 662755001844 Switch I region; other site 662755001845 G2 box; other site 662755001846 G3 box; other site 662755001847 Switch II region; other site 662755001848 G4 box; other site 662755001849 G5 box; other site 662755001850 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 662755001851 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 662755001852 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 662755001853 Predicted membrane protein [Function unknown]; Region: COG1289 662755001854 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 662755001855 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 662755001856 putative active site [active] 662755001857 putative metal binding site [ion binding]; other site 662755001858 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 662755001859 sulfoacetaldehyde acetyltransferase; Region: sulphoacet_xsc; TIGR03457 662755001860 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 662755001861 PYR/PP interface [polypeptide binding]; other site 662755001862 dimer interface [polypeptide binding]; other site 662755001863 TPP binding site [chemical binding]; other site 662755001864 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 662755001865 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 662755001866 TPP-binding site [chemical binding]; other site 662755001867 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 662755001868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755001869 ATP binding site [chemical binding]; other site 662755001870 putative Mg++ binding site [ion binding]; other site 662755001871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755001872 nucleotide binding region [chemical binding]; other site 662755001873 ATP-binding site [chemical binding]; other site 662755001874 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 662755001875 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 662755001876 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 662755001877 dimer interface [polypeptide binding]; other site 662755001878 putative anticodon binding site; other site 662755001879 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 662755001880 motif 1; other site 662755001881 dimer interface [polypeptide binding]; other site 662755001882 active site 662755001883 motif 2; other site 662755001884 motif 3; other site 662755001885 BCCT family transporter; Region: BCCT; cl00569 662755001886 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 662755001887 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 662755001888 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 662755001889 CsbD-like; Region: CsbD; cl01272 662755001890 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 662755001891 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 662755001892 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 662755001893 Walker A/P-loop; other site 662755001894 ATP binding site [chemical binding]; other site 662755001895 Q-loop/lid; other site 662755001896 ABC transporter signature motif; other site 662755001897 Walker B; other site 662755001898 D-loop; other site 662755001899 H-loop/switch region; other site 662755001900 aspartate aminotransferase; Provisional; Region: PRK08361 662755001901 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 662755001902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755001903 homodimer interface [polypeptide binding]; other site 662755001904 catalytic residue [active] 662755001905 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755001906 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 662755001907 substrate binding pocket [chemical binding]; other site 662755001908 catalytic triad [active] 662755001909 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 662755001910 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 662755001911 active site 662755001912 Zn binding site [ion binding]; other site 662755001913 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 662755001914 putative bifunctional 4-alpha-glucanotransferase/glycogen debranching enzyme; Provisional; Region: PRK14510 662755001915 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 662755001916 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755001917 coproporphyrinogen III oxidase; Validated; Region: PRK05628 662755001918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 662755001919 HemN C-terminal region; Region: HemN_C; pfam06969 662755001920 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 662755001921 HrcA protein C terminal domain; Region: HrcA; pfam01628 662755001922 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 662755001923 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 662755001924 HSP70 interaction site [polypeptide binding]; other site 662755001925 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 662755001926 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 662755001927 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 662755001928 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 662755001929 PhoH-like protein; Region: PhoH; cl12134 662755001930 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 662755001931 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 662755001932 Domain of unknown function DUF21; Region: DUF21; pfam01595 662755001933 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 662755001934 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 662755001935 Transporter associated domain; Region: CorC_HlyC; cl08393 662755001936 GTPase Era; Reviewed; Region: era; PRK00089 662755001937 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 662755001938 G1 box; other site 662755001939 GTP/Mg2+ binding site [chemical binding]; other site 662755001940 Switch I region; other site 662755001941 G2 box; other site 662755001942 Switch II region; other site 662755001943 G3 box; other site 662755001944 G4 box; other site 662755001945 G5 box; other site 662755001946 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 662755001947 Recombination protein O N terminal; Region: RecO_N; pfam11967 662755001948 Recombination protein O C terminal; Region: RecO_C; pfam02565 662755001949 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 662755001950 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 662755001951 catalytic residue [active] 662755001952 putative FPP diphosphate binding site; other site 662755001953 putative FPP binding hydrophobic cleft; other site 662755001954 dimer interface [polypeptide binding]; other site 662755001955 putative IPP diphosphate binding site; other site 662755001956 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 662755001957 dinuclear metal binding motif [ion binding]; other site 662755001958 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 662755001959 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 662755001960 metal binding site 2 [ion binding]; metal-binding site 662755001961 putative DNA binding helix; other site 662755001962 metal binding site 1 [ion binding]; metal-binding site 662755001963 dimer interface [polypeptide binding]; other site 662755001964 structural Zn2+ binding site [ion binding]; other site 662755001965 MULE transposase domain; Region: MULE; pfam10551 662755001966 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755001967 glycyl-tRNA synthetase; Provisional; Region: PRK04173 662755001968 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 662755001969 motif 1; other site 662755001970 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 662755001971 active site 662755001972 motif 2; other site 662755001973 motif 3; other site 662755001974 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 662755001975 anticodon binding site; other site 662755001976 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 662755001977 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 662755001978 putative active site [active] 662755001979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 662755001980 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 662755001981 active site 662755001982 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 662755001983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755001984 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 662755001985 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 662755001986 DNA primase; Validated; Region: dnaG; PRK05667 662755001987 CHC2 zinc finger; Region: zf-CHC2; cl02597 662755001988 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 662755001989 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 662755001990 active site 662755001991 metal binding site [ion binding]; metal-binding site 662755001992 interdomain interaction site; other site 662755001993 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 662755001994 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 662755001995 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 662755001996 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 662755001997 NAD binding site [chemical binding]; other site 662755001998 catalytic Zn binding site [ion binding]; other site 662755001999 substrate binding site [chemical binding]; other site 662755002000 structural Zn binding site [ion binding]; other site 662755002001 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 662755002002 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 662755002003 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 662755002004 metal-binding site [ion binding] 662755002005 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 662755002006 MULE transposase domain; Region: MULE; pfam10551 662755002007 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755002008 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 662755002009 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 662755002010 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 662755002011 Beta-lactamase; Region: Beta-lactamase; cl01009 662755002012 Phosphopantetheine attachment site; Region: PP-binding; cl09936 662755002013 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 662755002014 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755002015 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 662755002016 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 662755002017 dimer interface [polypeptide binding]; other site 662755002018 TPP-binding site [chemical binding]; other site 662755002019 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 662755002020 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 662755002021 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 662755002022 Low molecular weight phosphatase family; Region: LMWPc; cd00115 662755002023 Active site [active] 662755002024 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 662755002025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755002026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 662755002027 active site 662755002028 motif I; other site 662755002029 motif II; other site 662755002030 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 662755002031 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 662755002032 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 662755002033 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 662755002034 Putative zinc ribbon domain; Region: DUF164; pfam02591 662755002035 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 662755002036 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 662755002037 RNA/DNA hybrid binding site [nucleotide binding]; other site 662755002038 active site 662755002039 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 662755002040 catalytic core [active] 662755002041 RNB domain; Region: RNB; pfam00773 662755002042 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 662755002043 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 662755002044 oligomerization interface [polypeptide binding]; other site 662755002045 active site 662755002046 metal binding site [ion binding]; metal-binding site 662755002047 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 662755002048 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 662755002049 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 662755002050 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 662755002051 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 662755002052 metal binding triad; other site 662755002053 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 662755002054 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 662755002055 metal binding triad; other site 662755002056 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 662755002057 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 662755002058 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 662755002059 hypothetical protein; Provisional; Region: PRK08912 662755002060 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 662755002061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755002062 homodimer interface [polypeptide binding]; other site 662755002063 catalytic residue [active] 662755002064 biotin synthase; Validated; Region: PRK06256 662755002065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 662755002066 FeS/SAM binding site; other site 662755002067 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 662755002068 Predicted membrane protein [Function unknown]; Region: COG1511 662755002069 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 662755002070 ABC-2 type transporter; Region: ABC2_membrane; cl11417 662755002071 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 662755002072 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 662755002073 Walker A/P-loop; other site 662755002074 ATP binding site [chemical binding]; other site 662755002075 Q-loop/lid; other site 662755002076 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 662755002077 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 662755002078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755002079 catalytic residue [active] 662755002080 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 662755002081 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 662755002082 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 662755002083 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 662755002084 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 662755002085 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 662755002086 carboxyltransferase (CT) interaction site; other site 662755002087 biotinylation site [posttranslational modification]; other site 662755002088 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 662755002089 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 662755002090 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 662755002091 LamB/YcsF family; Region: LamB_YcsF; cl00664 662755002092 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 662755002093 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 662755002094 FMN binding site [chemical binding]; other site 662755002095 active site 662755002096 substrate binding site [chemical binding]; other site 662755002097 catalytic residue [active] 662755002098 glutamine synthetase, type I; Region: GlnA; TIGR00653 662755002099 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 662755002100 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 662755002101 RDD family; Region: RDD; cl00746 662755002102 LysE type translocator; Region: LysE; cl00565 662755002103 lipoyl synthase; Provisional; Region: PRK05481 662755002104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 662755002105 FeS/SAM binding site; other site 662755002106 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 662755002107 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 662755002108 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 662755002109 E3 interaction surface; other site 662755002110 lipoyl attachment site [posttranslational modification]; other site 662755002111 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 662755002112 E3 interaction surface; other site 662755002113 lipoyl attachment site [posttranslational modification]; other site 662755002114 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 662755002115 E3 interaction surface; other site 662755002116 lipoyl attachment site [posttranslational modification]; other site 662755002117 e3 binding domain; Region: E3_binding; pfam02817 662755002118 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 662755002119 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 662755002120 multifunctional aminopeptidase A; Provisional; Region: PRK00913 662755002121 interface (dimer of trimers) [polypeptide binding]; other site 662755002122 Substrate-binding/catalytic site; other site 662755002123 Zn-binding sites [ion binding]; other site 662755002124 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 662755002125 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 662755002126 homodimer interface [polypeptide binding]; other site 662755002127 substrate-cofactor binding pocket; other site 662755002128 catalytic residue [active] 662755002129 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 662755002130 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 662755002131 active site pocket [active] 662755002132 putative dimer interface [polypeptide binding]; other site 662755002133 putative cataytic base [active] 662755002134 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 662755002135 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 662755002136 PspC domain; Region: PspC; cl00864 662755002137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 662755002138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 662755002139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755002140 active site 662755002141 phosphorylation site [posttranslational modification] 662755002142 intermolecular recognition site; other site 662755002143 dimerization interface [polypeptide binding]; other site 662755002144 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 662755002145 DNA binding residues [nucleotide binding] 662755002146 dimerization interface [polypeptide binding]; other site 662755002147 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 662755002148 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 662755002149 active site 662755002150 dimer interface [polypeptide binding]; other site 662755002151 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 662755002152 Ligand Binding Site [chemical binding]; other site 662755002153 Molecular Tunnel; other site 662755002154 pyruvate dehydrogenase; Provisional; Region: PRK06546 662755002155 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 662755002156 PYR/PP interface [polypeptide binding]; other site 662755002157 tetramer interface [polypeptide binding]; other site 662755002158 dimer interface [polypeptide binding]; other site 662755002159 TPP binding site [chemical binding]; other site 662755002160 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 662755002161 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 662755002162 TPP-binding site [chemical binding]; other site 662755002163 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 662755002164 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 662755002165 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 662755002166 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 662755002167 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 662755002168 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 662755002169 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 662755002170 Subunit I/III interface [polypeptide binding]; other site 662755002171 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 662755002172 Cytochrome c; Region: Cytochrom_C; cl11414 662755002173 Cytochrome c; Region: Cytochrom_C; cl11414 662755002174 Cytochrome c; Region: Cytochrom_C; cl11414 662755002175 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 662755002176 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 662755002177 iron-sulfur cluster [ion binding]; other site 662755002178 [2Fe-2S] cluster binding site [ion binding]; other site 662755002179 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 662755002180 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 662755002181 heme bH binding site [chemical binding]; other site 662755002182 intrachain domain interface; other site 662755002183 heme bL binding site [chemical binding]; other site 662755002184 interchain domain interface [polypeptide binding]; other site 662755002185 Qo binding site; other site 662755002186 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 662755002187 active site 662755002188 substrate binding site [chemical binding]; other site 662755002189 catalytic site [active] 662755002190 NlpC/P60 family; Region: NLPC_P60; cl11438 662755002191 Spc7 kinetochore protein; Region: Spc7; smart00787 662755002192 NlpC/P60 family; Region: NLPC_P60; cl11438 662755002193 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 662755002194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 662755002195 Predicted permease [General function prediction only]; Region: COG2985 662755002196 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 662755002197 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 662755002198 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 662755002199 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 662755002200 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 662755002201 catalytic site [active] 662755002202 metal binding site [ion binding]; metal-binding site 662755002203 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 662755002204 putative acyl-acceptor binding pocket; other site 662755002205 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 662755002206 Acyltransferase family; Region: Acyl_transf_3; pfam01757 662755002207 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 662755002208 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 662755002209 Catalytic domain of Protein Kinases; Region: PKc; cd00180 662755002210 active site 662755002211 ATP binding site [chemical binding]; other site 662755002212 substrate binding site [chemical binding]; other site 662755002213 activation loop (A-loop); other site 662755002214 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 662755002215 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 662755002216 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 662755002217 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 662755002218 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 662755002219 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 662755002220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755002221 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 662755002222 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 662755002223 substrate binding pocket [chemical binding]; other site 662755002224 chain length determination region; other site 662755002225 substrate-Mg2+ binding site; other site 662755002226 catalytic residues [active] 662755002227 aspartate-rich region 1; other site 662755002228 active site lid residues [active] 662755002229 aspartate-rich region 2; other site 662755002230 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 662755002231 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 662755002232 FAD binding site [chemical binding]; other site 662755002233 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 662755002234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755002235 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 662755002236 MULE transposase domain; Region: MULE; pfam10551 662755002237 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755002238 cell division protein MraZ; Reviewed; Region: PRK00326 662755002239 MraZ protein; Region: MraZ; pfam02381 662755002240 MraZ protein; Region: MraZ; pfam02381 662755002241 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 662755002242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755002243 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 662755002244 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 662755002245 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 662755002246 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 662755002247 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 662755002248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 662755002249 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 662755002250 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 662755002251 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 662755002252 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 662755002253 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 662755002254 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 662755002255 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 662755002256 Mg++ binding site [ion binding]; other site 662755002257 putative catalytic motif [active] 662755002258 putative substrate binding site [chemical binding]; other site 662755002259 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 662755002260 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 662755002261 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 662755002262 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 662755002263 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 662755002264 active site 662755002265 homodimer interface [polypeptide binding]; other site 662755002266 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 662755002267 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 662755002268 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 662755002269 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 662755002270 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 662755002271 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 662755002272 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 662755002273 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 662755002274 nucleotide binding site [chemical binding]; other site 662755002275 SulA interaction site; other site 662755002276 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 662755002277 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 662755002278 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 662755002279 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 662755002280 catalytic residue [active] 662755002281 Protein of unknown function (DUF552); Region: DUF552; cl00775 662755002282 YGGT family; Region: YGGT; cl00508 662755002283 DivIVA domain; Region: DivI1A_domain; TIGR03544 662755002284 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 662755002285 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 662755002286 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 662755002287 HIGH motif; other site 662755002288 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 662755002289 active site 662755002290 KMSKS motif; other site 662755002291 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 662755002292 tRNA binding surface [nucleotide binding]; other site 662755002293 anticodon binding site; other site 662755002294 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 662755002295 EamA-like transporter family; Region: EamA; cl01037 662755002296 DNA polymerase IV; Provisional; Region: PRK03348 662755002297 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 662755002298 active site 662755002299 DNA binding site [nucleotide binding] 662755002300 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 662755002301 active site/substrate binding site [active] 662755002302 tetramer interface [polypeptide binding]; other site 662755002303 lipoprotein signal peptidase; Provisional; Region: PRK14787 662755002304 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 662755002305 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 662755002306 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 662755002307 active site 662755002308 Predicted permeases [General function prediction only]; Region: RarD; COG2962 662755002309 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 662755002310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 662755002311 dimer interface [polypeptide binding]; other site 662755002312 active site 662755002313 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 662755002314 substrate binding site [chemical binding]; other site 662755002315 catalytic residue [active] 662755002316 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 662755002317 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 662755002318 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 662755002319 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 662755002320 generic binding surface II; other site 662755002321 generic binding surface I; other site 662755002322 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 662755002323 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 662755002324 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 662755002325 Uncharacterized conserved protein [Function unknown]; Region: COG1739 662755002326 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 662755002327 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 662755002328 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 662755002329 RNA binding surface [nucleotide binding]; other site 662755002330 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 662755002331 synthetase active site [active] 662755002332 NTP binding site [chemical binding]; other site 662755002333 metal binding site [ion binding]; metal-binding site 662755002334 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 662755002335 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 662755002336 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 662755002337 Dimer interface [polypeptide binding]; other site 662755002338 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 662755002339 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 662755002340 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 662755002341 tetracycline repressor protein TetR; Provisional; Region: PRK13756 662755002342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 662755002343 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 662755002344 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 662755002345 NAD binding site [chemical binding]; other site 662755002346 dimerization interface [polypeptide binding]; other site 662755002347 product binding site; other site 662755002348 substrate binding site [chemical binding]; other site 662755002349 zinc binding site [ion binding]; other site 662755002350 catalytic residues [active] 662755002351 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 662755002352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 662755002353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755002354 homodimer interface [polypeptide binding]; other site 662755002355 catalytic residue [active] 662755002356 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 662755002357 putative active site pocket [active] 662755002358 4-fold oligomerization interface [polypeptide binding]; other site 662755002359 metal binding residues [ion binding]; metal-binding site 662755002360 3-fold/trimer interface [polypeptide binding]; other site 662755002361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755002362 putative substrate translocation pore; other site 662755002363 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 662755002364 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 662755002365 putative active site [active] 662755002366 oxyanion strand; other site 662755002367 catalytic triad [active] 662755002368 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 662755002369 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 662755002370 catalytic residues [active] 662755002371 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 662755002372 active site 662755002373 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 662755002374 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 662755002375 substrate binding site [chemical binding]; other site 662755002376 glutamase interaction surface [polypeptide binding]; other site 662755002377 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 662755002378 anthranilate synthase component I; Provisional; Region: PRK13571 662755002379 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 662755002380 chorismate binding enzyme; Region: Chorismate_bind; cl10555 662755002381 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl09759 662755002382 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 662755002383 active site 662755002384 ribulose/triose binding site [chemical binding]; other site 662755002385 phosphate binding site [ion binding]; other site 662755002386 substrate (anthranilate) binding pocket [chemical binding]; other site 662755002387 product (indole) binding pocket [chemical binding]; other site 662755002388 tryptophan synthase, beta chain; Region: PLN02618 662755002389 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 662755002390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755002391 catalytic residue [active] 662755002392 tryptophan synthase; Region: PLN02591 662755002393 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 662755002394 substrate binding site [chemical binding]; other site 662755002395 active site 662755002396 catalytic residues [active] 662755002397 heterodimer interface [polypeptide binding]; other site 662755002398 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 662755002399 pyruvate kinase; Provisional; Region: PRK06247 662755002400 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 662755002401 domain interfaces; other site 662755002402 active site 662755002403 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 662755002404 amidohydrolase; Region: amidohydrolases; TIGR01891 662755002405 metal binding site [ion binding]; metal-binding site 662755002406 putative dimer interface [polypeptide binding]; other site 662755002407 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 662755002408 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 662755002409 nucleotide binding site/active site [active] 662755002410 HIT family signature motif; other site 662755002411 catalytic residue [active] 662755002412 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 662755002413 active site 662755002414 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 662755002415 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 662755002416 Walker A/P-loop; other site 662755002417 ATP binding site [chemical binding]; other site 662755002418 Q-loop/lid; other site 662755002419 ABC transporter signature motif; other site 662755002420 Walker B; other site 662755002421 D-loop; other site 662755002422 H-loop/switch region; other site 662755002423 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 662755002424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755002425 dimer interface [polypeptide binding]; other site 662755002426 conserved gate region; other site 662755002427 putative PBP binding loops; other site 662755002428 ABC-ATPase subunit interface; other site 662755002429 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 662755002430 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 662755002431 substrate binding pocket [chemical binding]; other site 662755002432 membrane-bound complex binding site; other site 662755002433 hinge residues; other site 662755002434 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 662755002435 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 662755002436 DNA binding site [nucleotide binding] 662755002437 active site 662755002438 Glutaminase; Region: Glutaminase; cl00907 662755002439 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 662755002440 anti sigma factor interaction site; other site 662755002441 regulatory phosphorylation site [posttranslational modification]; other site 662755002442 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 662755002443 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 662755002444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 662755002445 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 662755002446 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 662755002447 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 662755002448 putative substrate binding pocket [chemical binding]; other site 662755002449 AC domain interface; other site 662755002450 catalytic triad [active] 662755002451 AB domain interface; other site 662755002452 interchain disulfide; other site 662755002453 Predicted helicase [General function prediction only]; Region: COG4889 662755002454 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 662755002455 catalytic residues [active] 662755002456 Recombinase; Region: Recombinase; pfam07508 662755002457 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 662755002458 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 662755002459 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 662755002460 catalytic residues [active] 662755002461 catalytic nucleophile [active] 662755002462 Recombinase; Region: Recombinase; pfam07508 662755002463 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 662755002464 GIY-YIG motif/motif A; other site 662755002465 putative active site [active] 662755002466 putative metal binding site [ion binding]; other site 662755002467 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 662755002468 amidase catalytic site [active] 662755002469 Zn binding residues [ion binding]; other site 662755002470 substrate binding site [chemical binding]; other site 662755002471 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 662755002472 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 662755002473 Holin family; Region: Phage_holin_4; cl01989 662755002474 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 662755002475 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 662755002476 gp58-like protein; Region: Gp58; pfam07902 662755002477 Phage tail protein; Region: Sipho_tail; cl11462 662755002478 Phage-related minor tail protein [Function unknown]; Region: COG5280 662755002479 Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192 662755002480 Phage-related protein [Function unknown]; Region: COG5412 662755002481 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 662755002482 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 662755002483 oligomerization interface [polypeptide binding]; other site 662755002484 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 662755002485 Phage capsid family; Region: Phage_capsid; pfam05065 662755002486 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 662755002487 oligomer interface [polypeptide binding]; other site 662755002488 active site residues [active] 662755002489 Phage-related protein [Function unknown]; Region: COG4695; cl01923 662755002490 Phage portal protein; Region: Phage_portal; pfam04860 662755002491 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 662755002492 Phage Terminase; Region: Terminase_1; pfam03354 662755002493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755002494 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 662755002495 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 662755002496 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 662755002497 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 662755002498 Phage terminase, small subunit; Region: Terminase_4; cl01525 662755002499 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 662755002500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755002501 ATP binding site [chemical binding]; other site 662755002502 putative Mg++ binding site [ion binding]; other site 662755002503 VRR-NUC domain; Region: VRR_NUC; cl08494 662755002504 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 662755002505 D5 N terminal like; Region: D5_N; cl07360 662755002506 C-terminal domain; Region: primase_Cterm; TIGR01613 662755002507 BRO family, N-terminal domain; Region: Bro-N; cl10591 662755002508 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 662755002509 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 662755002510 active site 662755002511 DNA binding site [nucleotide binding] 662755002512 catalytic site [active] 662755002513 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 662755002514 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 662755002515 sporulation sigma factor SigF; Validated; Region: PRK05572 662755002516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 662755002517 DNA binding residues [nucleotide binding] 662755002518 Predicted ATPase [General function prediction only]; Region: COG5293 662755002519 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 662755002520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755002521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755002522 Restriction endonuclease [Defense mechanisms]; Region: COG3587 662755002523 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755002524 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 662755002525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755002526 ATP binding site [chemical binding]; other site 662755002527 putative Mg++ binding site [ion binding]; other site 662755002528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755002529 nucleotide binding region [chemical binding]; other site 662755002530 ATP-binding site [chemical binding]; other site 662755002531 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 662755002532 Predicted helicase [General function prediction only]; Region: COG4889 662755002533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755002534 ATP binding site [chemical binding]; other site 662755002535 putative Mg++ binding site [ion binding]; other site 662755002536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755002537 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 662755002538 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 662755002539 active site 662755002540 substrate binding site [chemical binding]; other site 662755002541 catalytic site [active] 662755002542 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 662755002543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 662755002544 DNA polymerase I; Provisional; Region: PRK05755 662755002545 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 662755002546 active site 662755002547 metal binding site 1 [ion binding]; metal-binding site 662755002548 putative 5' ssDNA interaction site; other site 662755002549 metal binding site 3; metal-binding site 662755002550 metal binding site 2 [ion binding]; metal-binding site 662755002551 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 662755002552 putative DNA binding site [nucleotide binding]; other site 662755002553 putative metal binding site [ion binding]; other site 662755002554 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 662755002555 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 662755002556 active site 662755002557 DNA binding site [nucleotide binding] 662755002558 catalytic site [active] 662755002559 Domain of unknown function (DUF368); Region: DUF368; cl00893 662755002560 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 662755002561 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 662755002562 RNA binding site [nucleotide binding]; other site 662755002563 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 662755002564 RNA binding site [nucleotide binding]; other site 662755002565 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 662755002566 RNA binding site [nucleotide binding]; other site 662755002567 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 662755002568 RNA binding site [nucleotide binding]; other site 662755002569 enoyl-CoA hydratase; Region: PLN02864 662755002570 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 662755002571 active site 2 [active] 662755002572 active site 1 [active] 662755002573 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 662755002574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755002575 NAD(P) binding site [chemical binding]; other site 662755002576 active site 662755002577 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 662755002578 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 662755002579 dimer interface [polypeptide binding]; other site 662755002580 active site 662755002581 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 662755002582 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 662755002583 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 662755002584 CoA-binding site [chemical binding]; other site 662755002585 ATP-binding [chemical binding]; other site 662755002586 excinuclease ABC subunit B; Provisional; Region: PRK05298 662755002587 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755002588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755002589 nucleotide binding region [chemical binding]; other site 662755002590 ATP-binding site [chemical binding]; other site 662755002591 Ultra-violet resistance protein B; Region: UvrB; pfam12344 662755002592 UvrB/uvrC motif; Region: UVR; pfam02151 662755002593 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 662755002594 Ligand Binding Site [chemical binding]; other site 662755002595 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 662755002596 UvrD/REP helicase; Region: UvrD-helicase; cl14126 662755002597 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 662755002598 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 662755002599 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 662755002600 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 662755002601 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 662755002602 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 662755002603 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 662755002604 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 662755002605 23S rRNA binding site [nucleotide binding]; other site 662755002606 L21 binding site [polypeptide binding]; other site 662755002607 L13 binding site [polypeptide binding]; other site 662755002608 TM2 domain; Region: TM2; cl00984 662755002609 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 662755002610 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 662755002611 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 662755002612 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 662755002613 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 662755002614 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 662755002615 dimer interface [polypeptide binding]; other site 662755002616 motif 1; other site 662755002617 active site 662755002618 motif 2; other site 662755002619 motif 3; other site 662755002620 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 662755002621 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 662755002622 putative tRNA-binding site [nucleotide binding]; other site 662755002623 B3/4 domain; Region: B3_4; cl11458 662755002624 tRNA synthetase B5 domain; Region: B5; cl08394 662755002625 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 662755002626 dimer interface [polypeptide binding]; other site 662755002627 motif 1; other site 662755002628 motif 3; other site 662755002629 motif 2; other site 662755002630 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 662755002631 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 662755002632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755002633 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 662755002634 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 662755002635 heterotetramer interface [polypeptide binding]; other site 662755002636 active site pocket [active] 662755002637 cleavage site 662755002638 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 662755002639 feedback inhibition sensing region; other site 662755002640 homohexameric interface [polypeptide binding]; other site 662755002641 nucleotide binding site [chemical binding]; other site 662755002642 N-acetyl-L-glutamate binding site [chemical binding]; other site 662755002643 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 662755002644 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 662755002645 inhibitor-cofactor binding pocket; inhibition site 662755002646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755002647 catalytic residue [active] 662755002648 ornithine carbamoyltransferase; Provisional; Region: PRK00779 662755002649 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 662755002650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755002651 arginine repressor; Region: argR_whole; TIGR01529 662755002652 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 662755002653 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 662755002654 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 662755002655 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 662755002656 ANP binding site [chemical binding]; other site 662755002657 Substrate Binding Site II [chemical binding]; other site 662755002658 Substrate Binding Site I [chemical binding]; other site 662755002659 argininosuccinate lyase; Provisional; Region: PRK00855 662755002660 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 662755002661 active sites [active] 662755002662 tetramer interface [polypeptide binding]; other site 662755002663 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 662755002664 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 662755002665 ATP binding site [chemical binding]; other site 662755002666 substrate interface [chemical binding]; other site 662755002667 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 662755002668 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 662755002669 ThiS interaction site; other site 662755002670 putative active site [active] 662755002671 tetramer interface [polypeptide binding]; other site 662755002672 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 662755002673 thiS-thiF/thiG interaction site; other site 662755002674 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 662755002675 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 662755002676 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 662755002677 active site 662755002678 thiamine phosphate binding site [chemical binding]; other site 662755002679 pyrophosphate binding site [ion binding]; other site 662755002680 ThiC family; Region: ThiC; cl08031 662755002681 Trm112p-like protein; Region: Trm112p; cl01066 662755002682 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 662755002683 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 662755002684 active site 662755002685 HIGH motif; other site 662755002686 dimer interface [polypeptide binding]; other site 662755002687 KMSKS motif; other site 662755002688 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 662755002689 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 662755002690 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 662755002691 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 662755002692 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 662755002693 Walker A/P-loop; other site 662755002694 ATP binding site [chemical binding]; other site 662755002695 Q-loop/lid; other site 662755002696 ABC transporter signature motif; other site 662755002697 Walker B; other site 662755002698 D-loop; other site 662755002699 H-loop/switch region; other site 662755002700 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 662755002701 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 662755002702 Walker A/P-loop; other site 662755002703 ATP binding site [chemical binding]; other site 662755002704 Q-loop/lid; other site 662755002705 ABC transporter signature motif; other site 662755002706 Walker B; other site 662755002707 D-loop; other site 662755002708 H-loop/switch region; other site 662755002709 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 662755002710 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 662755002711 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 662755002712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755002713 dimer interface [polypeptide binding]; other site 662755002714 conserved gate region; other site 662755002715 putative PBP binding loops; other site 662755002716 ABC-ATPase subunit interface; other site 662755002717 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 662755002718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755002719 dimer interface [polypeptide binding]; other site 662755002720 conserved gate region; other site 662755002721 putative PBP binding loops; other site 662755002722 ABC-ATPase subunit interface; other site 662755002723 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 662755002724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755002725 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 662755002726 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 662755002727 RNA binding surface [nucleotide binding]; other site 662755002728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755002729 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 662755002730 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 662755002731 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 662755002732 Walker A/P-loop; other site 662755002733 ATP binding site [chemical binding]; other site 662755002734 Q-loop/lid; other site 662755002735 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755002736 Walker B; other site 662755002737 D-loop; other site 662755002738 H-loop/switch region; other site 662755002739 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 662755002740 Thiamine pyrophosphokinase; Region: TPK; cl09135 662755002741 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 662755002742 CTP synthetase; Validated; Region: pyrG; PRK05380 662755002743 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 662755002744 Catalytic site [active] 662755002745 Active site [active] 662755002746 UTP binding site [chemical binding]; other site 662755002747 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 662755002748 active site 662755002749 putative oxyanion hole; other site 662755002750 catalytic triad [active] 662755002751 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 662755002752 dimer interface [polypeptide binding]; other site 662755002753 ADP-ribose binding site [chemical binding]; other site 662755002754 active site 662755002755 nudix motif; other site 662755002756 metal binding site [ion binding]; metal-binding site 662755002757 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 662755002758 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 662755002759 DNA binding site [nucleotide binding] 662755002760 Int/Topo IB signature motif; other site 662755002761 active site 662755002762 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 662755002763 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 662755002764 P-loop; other site 662755002765 Magnesium ion binding site [ion binding]; other site 662755002766 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 662755002767 Magnesium ion binding site [ion binding]; other site 662755002768 ScpA/B protein; Region: ScpA_ScpB; cl00598 662755002769 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 662755002770 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 662755002771 active site 662755002772 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 662755002773 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 662755002774 RNA binding surface [nucleotide binding]; other site 662755002775 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 662755002776 active site 662755002777 cytidylate kinase; Provisional; Region: cmk; PRK00023 662755002778 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 662755002779 CMP-binding site; other site 662755002780 The sites determining sugar specificity; other site 662755002781 GTP-binding protein Der; Reviewed; Region: PRK03003 662755002782 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 662755002783 G1 box; other site 662755002784 GTP/Mg2+ binding site [chemical binding]; other site 662755002785 Switch I region; other site 662755002786 G2 box; other site 662755002787 Switch II region; other site 662755002788 G3 box; other site 662755002789 G4 box; other site 662755002790 G5 box; other site 662755002791 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 662755002792 G1 box; other site 662755002793 GTP/Mg2+ binding site [chemical binding]; other site 662755002794 Switch I region; other site 662755002795 G2 box; other site 662755002796 G3 box; other site 662755002797 Switch II region; other site 662755002798 G4 box; other site 662755002799 G5 box; other site 662755002800 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 662755002801 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 662755002802 Potassium binding sites [ion binding]; other site 662755002803 Cesium cation binding sites [ion binding]; other site 662755002804 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 662755002805 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 662755002806 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 662755002807 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 662755002808 Predicted esterase [General function prediction only]; Region: COG0627 662755002809 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 662755002810 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 662755002811 active site 662755002812 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 662755002813 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 662755002814 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 662755002815 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 662755002816 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 662755002817 phosphopeptide binding site; other site 662755002818 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 662755002819 DNA binding residues [nucleotide binding] 662755002820 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 662755002821 DNA binding residues [nucleotide binding] 662755002822 putative dimer interface [polypeptide binding]; other site 662755002823 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 662755002824 metal ion-dependent adhesion site (MIDAS); other site 662755002825 Domain of unknown function DUF21; Region: DUF21; pfam01595 662755002826 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 662755002827 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 662755002828 Domain of unknown function DUF21; Region: DUF21; pfam01595 662755002829 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 662755002830 Transporter associated domain; Region: CorC_HlyC; cl08393 662755002831 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755002832 ATP binding site [chemical binding]; other site 662755002833 putative Mg++ binding site [ion binding]; other site 662755002834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755002835 nucleotide binding region [chemical binding]; other site 662755002836 ATP-binding site [chemical binding]; other site 662755002837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755002838 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 662755002839 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 662755002840 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 662755002841 CoenzymeA binding site [chemical binding]; other site 662755002842 subunit interaction site [polypeptide binding]; other site 662755002843 PHB binding site; other site 662755002844 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 662755002845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755002846 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 662755002847 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 662755002848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755002849 metabolite-proton symporter; Region: 2A0106; TIGR00883 662755002850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755002851 putative substrate translocation pore; other site 662755002852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755002853 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 662755002854 amidase; Provisional; Region: PRK12470 662755002855 Secretory lipase; Region: LIP; pfam03583 662755002856 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 662755002857 Cation transport protein; Region: TrkH; cl10514 662755002858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755002859 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 662755002860 MgtE intracellular N domain; Region: MgtE_N; cl15244 662755002861 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 662755002862 Divalent cation transporter; Region: MgtE; cl00786 662755002863 YceI-like domain; Region: YceI; cl01001 662755002864 Integrase core domain; Region: rve; cl01316 662755002865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 662755002866 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 662755002867 Ligand binding site [chemical binding]; other site 662755002868 Putative Catalytic site [active] 662755002869 DXD motif; other site 662755002870 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 662755002871 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 662755002872 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 662755002873 putative active site [active] 662755002874 catalytic triad [active] 662755002875 putative dimer interface [polypeptide binding]; other site 662755002876 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 662755002877 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 662755002878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755002879 NAD(P) binding site [chemical binding]; other site 662755002880 active site 662755002881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755002882 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 662755002883 ATP binding site [chemical binding]; other site 662755002884 putative Mg++ binding site [ion binding]; other site 662755002885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755002886 nucleotide binding region [chemical binding]; other site 662755002887 ATP-binding site [chemical binding]; other site 662755002888 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 662755002889 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 662755002890 Predicted transcriptional regulator [Transcription]; Region: COG2378 662755002891 Predicted transcriptional regulator [Transcription]; Region: COG2378 662755002892 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 662755002893 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 662755002894 Pup-like protein; Region: Pup; cl05289 662755002895 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 662755002896 Pup-ligase protein; Region: Pup_ligase; pfam03136 662755002897 proteasome ATPase; Region: pup_AAA; TIGR03689 662755002898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755002899 Walker A motif; other site 662755002900 ATP binding site [chemical binding]; other site 662755002901 Walker B motif; other site 662755002902 arginine finger; other site 662755002903 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 662755002904 active site 662755002905 metal binding site [ion binding]; metal-binding site 662755002906 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 662755002907 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 662755002908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 662755002909 S-adenosylmethionine binding site [chemical binding]; other site 662755002910 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 662755002911 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 662755002912 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 662755002913 Aspartase; Region: Aspartase; cd01357 662755002914 active sites [active] 662755002915 tetramer interface [polypeptide binding]; other site 662755002916 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 662755002917 ATP phosphoribosyltransferase; Region: HisG; cl15266 662755002918 HisG, C-terminal domain; Region: HisG_C; cl06867 662755002919 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 662755002920 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 662755002921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 662755002922 motif II; other site 662755002923 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 662755002924 CoenzymeA binding site [chemical binding]; other site 662755002925 subunit interaction site [polypeptide binding]; other site 662755002926 PHB binding site; other site 662755002927 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 662755002928 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 662755002929 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 662755002930 substrate binding pocket [chemical binding]; other site 662755002931 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 662755002932 B12 binding site [chemical binding]; other site 662755002933 cobalt ligand [ion binding]; other site 662755002934 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 662755002935 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 662755002936 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 662755002937 active site 662755002938 HIGH motif; other site 662755002939 nucleotide binding site [chemical binding]; other site 662755002940 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 662755002941 active site 662755002942 KMSKS motif; other site 662755002943 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 662755002944 Bacitracin resistance protein BacA; Region: BacA; cl00858 662755002945 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 662755002946 quinone interaction residues [chemical binding]; other site 662755002947 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 662755002948 active site 662755002949 catalytic residues [active] 662755002950 FMN binding site [chemical binding]; other site 662755002951 substrate binding site [chemical binding]; other site 662755002952 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 662755002953 substrate binding site [chemical binding]; other site 662755002954 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 662755002955 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 662755002956 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 662755002957 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 662755002958 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 662755002959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 662755002960 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 662755002961 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 662755002962 NlpC/P60 family; Region: NLPC_P60; cl11438 662755002963 aconitate hydratase; Validated; Region: PRK09277 662755002964 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 662755002965 substrate binding site [chemical binding]; other site 662755002966 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 662755002967 ligand binding site [chemical binding]; other site 662755002968 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 662755002969 substrate binding site [chemical binding]; other site 662755002970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 662755002971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 662755002972 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 662755002973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755002974 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 662755002975 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 662755002976 dimer interface [polypeptide binding]; other site 662755002977 PYR/PP interface [polypeptide binding]; other site 662755002978 TPP binding site [chemical binding]; other site 662755002979 substrate binding site [chemical binding]; other site 662755002980 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008 662755002981 TPP-binding site; other site 662755002982 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 662755002983 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 662755002984 catalytic triad [active] 662755002985 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 662755002986 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 662755002987 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 662755002988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755002989 Walker A/P-loop; other site 662755002990 ATP binding site [chemical binding]; other site 662755002991 ABC transporter signature motif; other site 662755002992 Walker B; other site 662755002993 D-loop; other site 662755002994 H-loop/switch region; other site 662755002995 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 662755002996 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 662755002997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755002998 Domain of unknown function DUF59; Region: DUF59; cl00941 662755002999 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 662755003000 trimerization site [polypeptide binding]; other site 662755003001 active site 662755003002 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 662755003003 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 662755003004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 662755003005 catalytic residue [active] 662755003006 FeS assembly ATPase SufC; Region: sufC; TIGR01978 662755003007 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 662755003008 Walker A/P-loop; other site 662755003009 ATP binding site [chemical binding]; other site 662755003010 Q-loop/lid; other site 662755003011 ABC transporter signature motif; other site 662755003012 Walker B; other site 662755003013 D-loop; other site 662755003014 H-loop/switch region; other site 662755003015 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 662755003016 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 662755003017 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 662755003018 FeS assembly protein SufB; Region: sufB; TIGR01980 662755003019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 662755003020 putative DNA binding site [nucleotide binding]; other site 662755003021 dimerization interface [polypeptide binding]; other site 662755003022 Predicted transcriptional regulator [Transcription]; Region: COG2345 662755003023 putative Zn2+ binding site [ion binding]; other site 662755003024 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 662755003025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755003026 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 662755003027 ABC transporter signature motif; other site 662755003028 Walker B; other site 662755003029 D-loop; other site 662755003030 H-loop/switch region; other site 662755003031 ABC-2 type transporter; Region: ABC2_membrane; cl11417 662755003032 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 662755003033 UbiA prenyltransferase family; Region: UbiA; cl00337 662755003034 transketolase; Reviewed; Region: PRK05899 662755003035 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 662755003036 TPP-binding site [chemical binding]; other site 662755003037 dimer interface [polypeptide binding]; other site 662755003038 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 662755003039 PYR/PP interface [polypeptide binding]; other site 662755003040 dimer interface [polypeptide binding]; other site 662755003041 TPP binding site [chemical binding]; other site 662755003042 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 662755003043 putative active site [active] 662755003044 transaldolase; Provisional; Region: PRK03903 662755003045 catalytic residue [active] 662755003046 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 662755003047 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 662755003048 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 662755003049 opcA protein; Region: OpcA; TIGR00534 662755003050 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 662755003051 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 662755003052 putative active site [active] 662755003053 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 662755003054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755003055 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 662755003056 substrate binding site [chemical binding]; other site 662755003057 dimer interface [polypeptide binding]; other site 662755003058 catalytic triad [active] 662755003059 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 662755003060 substrate binding site [chemical binding]; other site 662755003061 hinge regions; other site 662755003062 ADP binding site [chemical binding]; other site 662755003063 catalytic site [active] 662755003064 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 662755003065 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 662755003066 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 662755003067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 662755003068 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 662755003069 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 662755003070 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 662755003071 phosphate binding site [ion binding]; other site 662755003072 putative substrate binding pocket [chemical binding]; other site 662755003073 dimer interface [polypeptide binding]; other site 662755003074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755003075 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 662755003076 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 662755003077 GIY-YIG motif/motif A; other site 662755003078 active site 662755003079 catalytic site [active] 662755003080 putative DNA binding site [nucleotide binding]; other site 662755003081 metal binding site [ion binding]; metal-binding site 662755003082 UvrB/uvrC motif; Region: UVR; pfam02151 662755003083 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 662755003084 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 662755003085 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 662755003086 homopentamer interface [polypeptide binding]; other site 662755003087 active site 662755003088 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 662755003089 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 662755003090 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 662755003091 dimerization interface [polypeptide binding]; other site 662755003092 active site 662755003093 Lumazine binding domain; Region: Lum_binding; pfam00677 662755003094 Lumazine binding domain; Region: Lum_binding; pfam00677 662755003095 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 662755003096 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 662755003097 catalytic motif [active] 662755003098 Zn binding site [ion binding]; other site 662755003099 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 662755003100 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 662755003101 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 662755003102 substrate binding site [chemical binding]; other site 662755003103 hexamer interface [polypeptide binding]; other site 662755003104 metal binding site [ion binding]; metal-binding site 662755003105 16S rRNA methyltransferase B; Provisional; Region: PRK14902 662755003106 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 662755003107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 662755003108 S-adenosylmethionine binding site [chemical binding]; other site 662755003109 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 662755003110 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 662755003111 putative active site [active] 662755003112 substrate binding site [chemical binding]; other site 662755003113 putative cosubstrate binding site; other site 662755003114 catalytic site [active] 662755003115 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 662755003116 substrate binding site [chemical binding]; other site 662755003117 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 662755003118 active site 662755003119 catalytic residues [active] 662755003120 metal binding site [ion binding]; metal-binding site 662755003121 primosome assembly protein PriA; Provisional; Region: PRK14873 662755003122 S-adenosylmethionine synthetase; Validated; Region: PRK05250 662755003123 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 662755003124 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 662755003125 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 662755003126 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 662755003127 Flavoprotein; Region: Flavoprotein; cl08021 662755003128 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 662755003129 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 662755003130 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 662755003131 catalytic site [active] 662755003132 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 662755003133 active site 662755003134 dimer interface [polypeptide binding]; other site 662755003135 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 662755003136 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 662755003137 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 662755003138 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 662755003139 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 662755003140 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 662755003141 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 662755003142 IMP binding site; other site 662755003143 dimer interface [polypeptide binding]; other site 662755003144 interdomain contacts; other site 662755003145 partial ornithine binding site; other site 662755003146 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 662755003147 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 662755003148 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 662755003149 catalytic site [active] 662755003150 subunit interface [polypeptide binding]; other site 662755003151 dihydroorotase; Validated; Region: pyrC; PRK09357 662755003152 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 662755003153 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 662755003154 active site 662755003155 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 662755003156 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 662755003157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755003158 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 662755003159 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 662755003160 putative RNA binding site [nucleotide binding]; other site 662755003161 elongation factor P; Validated; Region: PRK00529 662755003162 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 662755003163 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 662755003164 RNA binding site [nucleotide binding]; other site 662755003165 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 662755003166 RNA binding site [nucleotide binding]; other site 662755003167 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 662755003168 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 662755003169 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 662755003170 active site 662755003171 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 662755003172 trimer interface [polypeptide binding]; other site 662755003173 active site 662755003174 dimer interface [polypeptide binding]; other site 662755003175 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 662755003176 active site 662755003177 dimer interface [polypeptide binding]; other site 662755003178 metal binding site [ion binding]; metal-binding site 662755003179 shikimate kinase; Reviewed; Region: aroK; PRK00131 662755003180 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 662755003181 ADP binding site [chemical binding]; other site 662755003182 magnesium binding site [ion binding]; other site 662755003183 putative shikimate binding site; other site 662755003184 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 662755003185 Tetramer interface [polypeptide binding]; other site 662755003186 Active site [active] 662755003187 FMN-binding site [chemical binding]; other site 662755003188 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 662755003189 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 662755003190 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 662755003191 shikimate binding site; other site 662755003192 NAD(P) binding site [chemical binding]; other site 662755003193 YceG-like family; Region: YceG; pfam02618 662755003194 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 662755003195 dimerization interface [polypeptide binding]; other site 662755003196 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 662755003197 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 662755003198 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 662755003199 motif 1; other site 662755003200 active site 662755003201 motif 2; other site 662755003202 motif 3; other site 662755003203 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 662755003204 DHHA1 domain; Region: DHHA1; pfam02272 662755003205 recombination factor protein RarA; Reviewed; Region: PRK13342 662755003206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755003207 Walker A motif; other site 662755003208 ATP binding site [chemical binding]; other site 662755003209 Walker B motif; other site 662755003210 arginine finger; other site 662755003211 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 662755003212 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 662755003213 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 662755003214 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 662755003215 dimer interface [polypeptide binding]; other site 662755003216 anticodon binding site; other site 662755003217 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 662755003218 homodimer interface [polypeptide binding]; other site 662755003219 motif 1; other site 662755003220 active site 662755003221 motif 2; other site 662755003222 GAD domain; Region: GAD; pfam02938 662755003223 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 662755003224 active site 662755003225 motif 3; other site 662755003226 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 662755003227 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 662755003228 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 662755003229 generic binding surface II; other site 662755003230 generic binding surface I; other site 662755003231 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 662755003232 putative active site [active] 662755003233 putative catalytic site [active] 662755003234 putative Mg binding site IVb [ion binding]; other site 662755003235 putative phosphate binding site [ion binding]; other site 662755003236 putative DNA binding site [nucleotide binding]; other site 662755003237 putative Mg binding site IVa [ion binding]; other site 662755003238 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 662755003239 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 662755003240 putative active site [active] 662755003241 putative metal binding site [ion binding]; other site 662755003242 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 662755003243 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 662755003244 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 662755003245 dimer interface [polypeptide binding]; other site 662755003246 motif 1; other site 662755003247 active site 662755003248 motif 2; other site 662755003249 motif 3; other site 662755003250 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 662755003251 anticodon binding site; other site 662755003252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 662755003253 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 662755003254 active site 662755003255 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 662755003256 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 662755003257 Zn2+ binding site [ion binding]; other site 662755003258 Mg2+ binding site [ion binding]; other site 662755003259 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 662755003260 synthetase active site [active] 662755003261 NTP binding site [chemical binding]; other site 662755003262 metal binding site [ion binding]; metal-binding site 662755003263 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 662755003264 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 662755003265 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 662755003266 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 662755003267 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 662755003268 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 662755003269 Protein export membrane protein; Region: SecD_SecF; cl14618 662755003270 Protein export membrane protein; Region: SecD_SecF; cl14618 662755003271 Preprotein translocase subunit; Region: YajC; cl00806 662755003272 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 662755003273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755003274 Walker A motif; other site 662755003275 ATP binding site [chemical binding]; other site 662755003276 Walker B motif; other site 662755003277 arginine finger; other site 662755003278 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 662755003279 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 662755003280 RuvA N terminal domain; Region: RuvA_N; pfam01330 662755003281 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 662755003282 active site 662755003283 putative DNA-binding cleft [nucleotide binding]; other site 662755003284 dimer interface [polypeptide binding]; other site 662755003285 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 662755003286 Domain of unknown function DUF28; Region: DUF28; cl00361 662755003287 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 662755003288 predicted active site [active] 662755003289 catalytic triad [active] 662755003290 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 662755003291 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 662755003292 active site 662755003293 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 662755003294 catalytic triad [active] 662755003295 dimer interface [polypeptide binding]; other site 662755003296 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 662755003297 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 662755003298 active site 662755003299 multimer interface [polypeptide binding]; other site 662755003300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 662755003301 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 662755003302 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 662755003303 putative acyl-acceptor binding pocket; other site 662755003304 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 662755003305 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 662755003306 nucleotide binding site/active site [active] 662755003307 HIT family signature motif; other site 662755003308 catalytic residue [active] 662755003309 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 662755003310 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 662755003311 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 662755003312 active site 662755003313 dimer interface [polypeptide binding]; other site 662755003314 motif 1; other site 662755003315 motif 2; other site 662755003316 motif 3; other site 662755003317 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 662755003318 anticodon binding site; other site 662755003319 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 662755003320 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 662755003321 Protein of unknown function (DUF461); Region: DUF461; cl01071 662755003322 Copper resistance protein CopC; Region: CopC; cl01012 662755003323 potential frameshift: common BLAST hit: gi|257067717|ref|YP_003153972.1| transposase 662755003324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 662755003325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 662755003326 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 662755003327 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 662755003328 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 662755003329 NAD binding site [chemical binding]; other site 662755003330 substrate binding site [chemical binding]; other site 662755003331 catalytic Zn binding site [ion binding]; other site 662755003332 tetramer interface [polypeptide binding]; other site 662755003333 structural Zn binding site [ion binding]; other site 662755003334 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 662755003335 Protein of unknown function (DUF419); Region: DUF419; cl15265 662755003336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 662755003337 MULE transposase domain; Region: MULE; pfam10551 662755003338 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755003339 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 662755003340 SelR domain; Region: SelR; cl00369 662755003341 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 662755003342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755003343 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 662755003344 substrate binding site [chemical binding]; other site 662755003345 active site 662755003346 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 662755003347 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 662755003348 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 662755003349 putative active site [active] 662755003350 catalytic site [active] 662755003351 putative substrate binding site [chemical binding]; other site 662755003352 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 662755003353 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 662755003354 TPP-binding site; other site 662755003355 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 662755003356 PYR/PP interface [polypeptide binding]; other site 662755003357 dimer interface [polypeptide binding]; other site 662755003358 TPP binding site [chemical binding]; other site 662755003359 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 662755003360 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 662755003361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755003362 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 662755003363 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 662755003364 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 662755003365 trimer interface [polypeptide binding]; other site 662755003366 active site 662755003367 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 662755003368 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 662755003369 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 662755003370 active site 662755003371 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 662755003372 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 662755003373 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 662755003374 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 662755003375 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 662755003376 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 662755003377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 662755003378 DNA binding residues [nucleotide binding] 662755003379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755003380 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 662755003381 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 662755003382 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 662755003383 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 662755003384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755003385 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cl00253 662755003386 dimerization interface [polypeptide binding]; other site 662755003387 putative tRNAtyr binding site [nucleotide binding]; other site 662755003388 putative active site [active] 662755003389 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 662755003390 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 662755003391 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 662755003392 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 662755003393 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 662755003394 DNA binding residues [nucleotide binding] 662755003395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755003396 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 662755003397 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 662755003398 PAC2 family; Region: PAC2; cl00847 662755003399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755003400 ATP binding site [chemical binding]; other site 662755003401 putative Mg++ binding site [ion binding]; other site 662755003402 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 662755003403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755003404 nucleotide binding region [chemical binding]; other site 662755003405 ATP-binding site [chemical binding]; other site 662755003406 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 662755003407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755003408 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 662755003409 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 662755003410 dimerization interface [polypeptide binding]; other site 662755003411 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 662755003412 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 662755003413 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755003414 ATP binding site [chemical binding]; other site 662755003415 putative Mg++ binding site [ion binding]; other site 662755003416 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755003417 Helicase associated domain (HA2); Region: HA2; cl04503 662755003418 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 662755003419 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 662755003420 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 662755003421 ATP cone domain; Region: ATP-cone; pfam03477 662755003422 LexA repressor; Validated; Region: PRK00215 662755003423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755003424 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 662755003425 Catalytic site [active] 662755003426 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 662755003427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755003428 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 662755003429 Sulfate transporter family; Region: Sulfate_transp; cl00967 662755003430 Permease family; Region: Xan_ur_permease; pfam00860 662755003431 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 662755003432 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 662755003433 G1 box; other site 662755003434 GTP/Mg2+ binding site [chemical binding]; other site 662755003435 Switch I region; other site 662755003436 G2 box; other site 662755003437 G3 box; other site 662755003438 Switch II region; other site 662755003439 G4 box; other site 662755003440 G5 box; other site 662755003441 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 662755003442 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 662755003443 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 662755003444 IPP transferase; Region: IPPT; cl00403 662755003445 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 662755003446 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 662755003447 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 662755003448 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 662755003449 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 662755003450 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 662755003451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 662755003452 FeS/SAM binding site; other site 662755003453 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 662755003454 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 662755003455 Walker A/P-loop; other site 662755003456 ATP binding site [chemical binding]; other site 662755003457 Q-loop/lid; other site 662755003458 ABC transporter signature motif; other site 662755003459 Walker B; other site 662755003460 D-loop; other site 662755003461 H-loop/switch region; other site 662755003462 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 662755003463 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 662755003464 substrate binding pocket [chemical binding]; other site 662755003465 membrane-bound complex binding site; other site 662755003466 hinge residues; other site 662755003467 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 662755003468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755003469 dimer interface [polypeptide binding]; other site 662755003470 conserved gate region; other site 662755003471 putative PBP binding loops; other site 662755003472 ABC-ATPase subunit interface; other site 662755003473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755003474 dimer interface [polypeptide binding]; other site 662755003475 conserved gate region; other site 662755003476 putative PBP binding loops; other site 662755003477 ABC-ATPase subunit interface; other site 662755003478 RecX family; Region: RecX; cl00936 662755003479 recombinase A; Provisional; Region: recA; PRK09354 662755003480 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 662755003481 hexamer interface [polypeptide binding]; other site 662755003482 Walker A motif; other site 662755003483 ATP binding site [chemical binding]; other site 662755003484 Walker B motif; other site 662755003485 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 662755003486 BioY family; Region: BioY; cl00560 662755003487 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 662755003488 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 662755003489 Walker A/P-loop; other site 662755003490 ATP binding site [chemical binding]; other site 662755003491 Q-loop/lid; other site 662755003492 ABC transporter signature motif; other site 662755003493 Walker B; other site 662755003494 D-loop; other site 662755003495 H-loop/switch region; other site 662755003496 Cobalt transport protein; Region: CbiQ; cl00463 662755003497 PspA/IM30 family; Region: PspA_IM30; pfam04012 662755003498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 662755003499 non-specific DNA binding site [nucleotide binding]; other site 662755003500 salt bridge; other site 662755003501 sequence-specific DNA binding site [nucleotide binding]; other site 662755003502 Competence-damaged protein; Region: CinA; cl00666 662755003503 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 662755003504 Integral membrane protein TerC family; Region: TerC; cl10468 662755003505 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 662755003506 DNA translocase FtsK; Provisional; Region: PRK10263 662755003507 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755003508 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 662755003509 TIGR03085 family protein; Region: TIGR03085 662755003510 DinB superfamily; Region: DinB_2; cl00986 662755003511 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 662755003512 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 662755003513 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 662755003514 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 662755003515 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 662755003516 dimer interface [polypeptide binding]; other site 662755003517 active site 662755003518 catalytic residue [active] 662755003519 Thymidylate synthase complementing protein; Region: Thy1; cl03630 662755003520 dihydrodipicolinate reductase; Provisional; Region: PRK00048 662755003521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755003522 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 662755003523 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 662755003524 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 662755003525 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 662755003526 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 662755003527 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 662755003528 putative nucleic acid binding region [nucleotide binding]; other site 662755003529 G-X-X-G motif; other site 662755003530 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 662755003531 RNA binding site [nucleotide binding]; other site 662755003532 domain interface; other site 662755003533 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 662755003534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 662755003535 catalytic residue [active] 662755003536 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 662755003537 16S/18S rRNA binding site [nucleotide binding]; other site 662755003538 S13e-L30e interaction site [polypeptide binding]; other site 662755003539 25S rRNA binding site [nucleotide binding]; other site 662755003540 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 662755003541 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 662755003542 active site 662755003543 Riboflavin kinase; Region: Flavokinase; cl03312 662755003544 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 662755003545 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 662755003546 RNA binding site [nucleotide binding]; other site 662755003547 active site 662755003548 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 662755003549 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 662755003550 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 662755003551 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 662755003552 active site 662755003553 metal binding site [ion binding]; metal-binding site 662755003554 putative efflux protein, MATE family; Region: matE; TIGR00797 662755003555 MatE; Region: MatE; cl10513 662755003556 MatE; Region: MatE; cl10513 662755003557 Ribosome-binding factor A; Region: RBFA; cl00542 662755003558 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 662755003559 translation initiation factor IF-2; Region: IF-2; TIGR00487 662755003560 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 662755003561 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 662755003562 G1 box; other site 662755003563 putative GEF interaction site [polypeptide binding]; other site 662755003564 GTP/Mg2+ binding site [chemical binding]; other site 662755003565 Switch I region; other site 662755003566 G2 box; other site 662755003567 G3 box; other site 662755003568 Switch II region; other site 662755003569 G4 box; other site 662755003570 G5 box; other site 662755003571 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 662755003572 Translation-initiation factor 2; Region: IF-2; pfam11987 662755003573 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 662755003574 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 662755003575 NusA N-terminal domain; Region: NusA_N; pfam08529 662755003576 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 662755003577 RNA binding site [nucleotide binding]; other site 662755003578 homodimer interface [polypeptide binding]; other site 662755003579 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 662755003580 G-X-X-G motif; other site 662755003581 ribosome maturation protein RimP; Reviewed; Region: PRK00092 662755003582 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 662755003583 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 662755003584 prolyl-tRNA synthetase; Provisional; Region: PRK09194 662755003585 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 662755003586 dimer interface [polypeptide binding]; other site 662755003587 motif 1; other site 662755003588 active site 662755003589 motif 2; other site 662755003590 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 662755003591 putative deacylase active site [active] 662755003592 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 662755003593 active site 662755003594 motif 3; other site 662755003595 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 662755003596 anticodon binding site; other site 662755003597 Protein of unknown function (DUF328); Region: DUF328; cl01143 662755003598 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 662755003599 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 662755003600 Predicted dehydrogenase [General function prediction only]; Region: COG0579 662755003601 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 662755003602 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755003603 mycothione reductase; Reviewed; Region: PRK07846 662755003604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755003605 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 662755003606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755003607 short chain dehydrogenase; Provisional; Region: PRK05650 662755003608 NAD(P) binding site [chemical binding]; other site 662755003609 active site 662755003610 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 662755003611 Predicted transcriptional regulators [Transcription]; Region: COG1725 662755003612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 662755003613 DNA-binding site [nucleotide binding]; DNA binding site 662755003614 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 662755003615 methionine aminopeptidase; Reviewed; Region: PRK07281 662755003616 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 662755003617 active site 662755003618 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 662755003619 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 662755003620 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 662755003621 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 662755003622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755003623 active site 662755003624 phosphorylation site [posttranslational modification] 662755003625 intermolecular recognition site; other site 662755003626 dimerization interface [polypeptide binding]; other site 662755003627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 662755003628 DNA binding residues [nucleotide binding] 662755003629 dimerization interface [polypeptide binding]; other site 662755003630 Acyltransferase family; Region: Acyl_transf_3; pfam01757 662755003631 Histidine kinase; Region: HisKA_3; pfam07730 662755003632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 662755003633 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 662755003634 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 662755003635 Walker A/P-loop; other site 662755003636 ATP binding site [chemical binding]; other site 662755003637 Q-loop/lid; other site 662755003638 ABC transporter signature motif; other site 662755003639 Walker B; other site 662755003640 D-loop; other site 662755003641 H-loop/switch region; other site 662755003642 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 662755003643 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 662755003644 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 662755003645 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 662755003646 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 662755003647 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 662755003648 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 662755003649 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 662755003650 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 662755003651 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 662755003652 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 662755003653 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 662755003654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 662755003655 FeS/SAM binding site; other site 662755003656 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 662755003657 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 662755003658 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 662755003659 hinge region; other site 662755003660 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 662755003661 putative nucleotide binding site [chemical binding]; other site 662755003662 uridine monophosphate binding site [chemical binding]; other site 662755003663 homohexameric interface [polypeptide binding]; other site 662755003664 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 662755003665 Integrase core domain; Region: rve; cl01316 662755003666 elongation factor Ts; Provisional; Region: tsf; PRK09377 662755003667 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 662755003668 Elongation factor TS; Region: EF_TS; pfam00889 662755003669 Elongation factor TS; Region: EF_TS; pfam00889 662755003670 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 662755003671 rRNA interaction site [nucleotide binding]; other site 662755003672 S8 interaction site; other site 662755003673 putative laminin-1 binding site; other site 662755003674 Peptidase family M23; Region: Peptidase_M23; pfam01551 662755003675 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 662755003676 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 662755003677 DNA binding site [nucleotide binding] 662755003678 Int/Topo IB signature motif; other site 662755003679 active site 662755003680 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 662755003681 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 662755003682 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 662755003683 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 662755003684 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755003685 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 662755003686 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 662755003687 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 662755003688 RNA/DNA hybrid binding site [nucleotide binding]; other site 662755003689 active site 662755003690 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 662755003691 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 662755003692 Catalytic site [active] 662755003693 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 662755003694 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 662755003695 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 662755003696 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 662755003697 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 662755003698 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 662755003699 RNA binding site [nucleotide binding]; other site 662755003700 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 662755003701 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 662755003702 NAD(P) binding site [chemical binding]; other site 662755003703 catalytic residues [active] 662755003704 BCCT family transporter; Region: BCCT; cl00569 662755003705 choline transport protein BetT; Provisional; Region: PRK09928 662755003706 choline dehydrogenase; Validated; Region: PRK02106 662755003707 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 662755003708 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 662755003709 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 662755003710 RimM N-terminal domain; Region: RimM; pfam01782 662755003711 glutamate dehydrogenase; Provisional; Region: PRK09414 662755003712 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 662755003713 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 662755003714 NAD(P) binding site [chemical binding]; other site 662755003715 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 662755003716 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 662755003717 signal recognition particle protein; Provisional; Region: PRK10867 662755003718 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 662755003719 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 662755003720 P loop; other site 662755003721 GTP binding site [chemical binding]; other site 662755003722 Signal peptide binding domain; Region: SRP_SPB; pfam02978 662755003723 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 662755003724 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 662755003725 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 662755003726 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 662755003727 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 662755003728 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 662755003729 Walker A/P-loop; other site 662755003730 ATP binding site [chemical binding]; other site 662755003731 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 662755003732 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 662755003733 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 662755003734 ABC transporter signature motif; other site 662755003735 Walker B; other site 662755003736 D-loop; other site 662755003737 H-loop/switch region; other site 662755003738 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 662755003739 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 662755003740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755003741 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 662755003742 dimerization interface [polypeptide binding]; other site 662755003743 putative DNA binding site [nucleotide binding]; other site 662755003744 putative Zn2+ binding site [ion binding]; other site 662755003745 Membrane transport protein; Region: Mem_trans; cl09117 662755003746 Low molecular weight phosphatase family; Region: LMWPc; cl00105 662755003747 Active site [active] 662755003748 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 662755003749 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 662755003750 DNA binding site [nucleotide binding] 662755003751 catalytic residue [active] 662755003752 H2TH interface [polypeptide binding]; other site 662755003753 putative catalytic residues [active] 662755003754 turnover-facilitating residue; other site 662755003755 intercalation triad [nucleotide binding]; other site 662755003756 8OG recognition residue [nucleotide binding]; other site 662755003757 putative reading head residues; other site 662755003758 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 662755003759 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 662755003760 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 662755003761 dimerization interface [polypeptide binding]; other site 662755003762 active site 662755003763 metal binding site [ion binding]; metal-binding site 662755003764 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 662755003765 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 662755003766 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 662755003767 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 662755003768 active site 662755003769 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 662755003770 (T/H)XGH motif; other site 662755003771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755003772 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 662755003773 carboxyltransferase (CT) interaction site; other site 662755003774 biotinylation site [posttranslational modification]; other site 662755003775 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 662755003776 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 662755003777 generic binding surface II; other site 662755003778 ssDNA binding site; other site 662755003779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755003780 ATP binding site [chemical binding]; other site 662755003781 putative Mg++ binding site [ion binding]; other site 662755003782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755003783 nucleotide binding region [chemical binding]; other site 662755003784 ATP-binding site [chemical binding]; other site 662755003785 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 662755003786 DAK2 domain; Region: Dak2; cl03685 662755003787 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 662755003788 ligand binding site [chemical binding]; other site 662755003789 active site 662755003790 UGI interface [polypeptide binding]; other site 662755003791 catalytic site [active] 662755003792 thiamine monophosphate kinase; Provisional; Region: PRK05731 662755003793 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 662755003794 ATP binding site [chemical binding]; other site 662755003795 dimerization interface [polypeptide binding]; other site 662755003796 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 662755003797 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 662755003798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 662755003799 non-specific DNA binding site [nucleotide binding]; other site 662755003800 salt bridge; other site 662755003801 sequence-specific DNA binding site [nucleotide binding]; other site 662755003802 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 662755003803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755003804 Cytochrome P450; Region: p450; cl12078 662755003805 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 662755003806 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 662755003807 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 662755003808 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 662755003809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755003810 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 662755003811 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 662755003812 active site 662755003813 Ap6A binding site [chemical binding]; other site 662755003814 nudix motif; other site 662755003815 metal binding site [ion binding]; metal-binding site 662755003816 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 662755003817 catalytic core [active] 662755003818 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 662755003819 substrate binding site [chemical binding]; other site 662755003820 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 662755003821 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 662755003822 substrate binding site [chemical binding]; other site 662755003823 ligand binding site [chemical binding]; other site 662755003824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755003825 Transcriptional regulator [Transcription]; Region: IclR; COG1414 662755003826 Bacterial transcriptional regulator; Region: IclR; pfam01614 662755003827 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 662755003828 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 662755003829 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 662755003830 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 662755003831 DNA binding residues [nucleotide binding] 662755003832 dimer interface [polypeptide binding]; other site 662755003833 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 662755003834 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 662755003835 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 662755003836 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 662755003837 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 662755003838 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 662755003839 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755003840 K+-transporting ATPase, c chain; Region: KdpC; cl00944 662755003841 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 662755003842 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 662755003843 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 662755003844 Ligand Binding Site [chemical binding]; other site 662755003845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 662755003846 dimer interface [polypeptide binding]; other site 662755003847 phosphorylation site [posttranslational modification] 662755003848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 662755003849 ATP binding site [chemical binding]; other site 662755003850 Mg2+ binding site [ion binding]; other site 662755003851 G-X-G motif; other site 662755003852 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 662755003853 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 662755003854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755003855 active site 662755003856 phosphorylation site [posttranslational modification] 662755003857 intermolecular recognition site; other site 662755003858 dimerization interface [polypeptide binding]; other site 662755003859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 662755003860 DNA binding site [nucleotide binding] 662755003861 OPT oligopeptide transporter protein; Region: OPT; cl14607 662755003862 putative oligopeptide transporter, OPT family; Region: TIGR00733 662755003863 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 662755003864 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 662755003865 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 662755003866 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 662755003867 GIY-YIG motif/motif A; other site 662755003868 active site 662755003869 catalytic site [active] 662755003870 PIF1-like helicase; Region: PIF1; pfam05970 662755003871 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 662755003872 Uncharacterized conserved protein [Function unknown]; Region: COG3410 662755003873 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 662755003874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 662755003875 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 662755003876 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 662755003877 FAD binding pocket [chemical binding]; other site 662755003878 FAD binding motif [chemical binding]; other site 662755003879 phosphate binding motif [ion binding]; other site 662755003880 beta-alpha-beta structure motif; other site 662755003881 NAD binding pocket [chemical binding]; other site 662755003882 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 662755003883 catalytic loop [active] 662755003884 iron binding site [ion binding]; other site 662755003885 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 662755003886 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 662755003887 putative di-iron ligands [ion binding]; other site 662755003888 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 662755003889 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 662755003890 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 662755003891 active site 662755003892 HIGH motif; other site 662755003893 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 662755003894 active site 662755003895 KMSKS motif; other site 662755003896 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755003897 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 662755003898 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755003899 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 662755003900 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 662755003901 putative transposase OrfB; Reviewed; Region: PHA02517 662755003902 Integrase core domain; Region: rve; cl01316 662755003903 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 662755003904 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 662755003905 ABC transporter signature motif; other site 662755003906 Walker B; other site 662755003907 D-loop; other site 662755003908 H-loop/switch region; other site 662755003909 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 662755003910 G4 box; other site 662755003911 GTP/Mg2+ binding site [chemical binding]; other site 662755003912 G5 box; other site 662755003913 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 662755003914 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 662755003915 G1 box; other site 662755003916 Walker A/P-loop; other site 662755003917 ATP binding site [chemical binding]; other site 662755003918 Q-loop/lid; other site 662755003919 ABC transporter signature motif; other site 662755003920 Walker B; other site 662755003921 D-loop; other site 662755003922 H-loop/switch region; other site 662755003923 Cobalt transport protein; Region: CbiQ; cl00463 662755003924 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 662755003925 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 662755003926 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755003927 Walker A/P-loop; other site 662755003928 ATP binding site [chemical binding]; other site 662755003929 Q-loop/lid; other site 662755003930 ABC transporter signature motif; other site 662755003931 Walker B; other site 662755003932 D-loop; other site 662755003933 H-loop/switch region; other site 662755003934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 662755003935 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 662755003936 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 662755003937 GTP/Mg2+ binding site [chemical binding]; other site 662755003938 G4 box; other site 662755003939 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755003940 G5 box; other site 662755003941 G1 box; other site 662755003942 Walker A/P-loop; other site 662755003943 ATP binding site [chemical binding]; other site 662755003944 Q-loop/lid; other site 662755003945 ABC transporter signature motif; other site 662755003946 Walker B; other site 662755003947 D-loop; other site 662755003948 H-loop/switch region; other site 662755003949 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755003950 MULE transposase domain; Region: MULE; pfam10551 662755003951 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 662755003952 Integrase core domain; Region: rve; cl01316 662755003953 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 662755003954 classical (c) SDRs; Region: SDR_c; cd05233 662755003955 NAD(P) binding site [chemical binding]; other site 662755003956 active site 662755003957 isochorismate synthase DhbC; Validated; Region: PRK06923 662755003958 chorismate binding enzyme; Region: Chorismate_bind; cl10555 662755003959 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 662755003960 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 662755003961 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 662755003962 active site 662755003963 substrate binding site [chemical binding]; other site 662755003964 catalytic site [active] 662755003965 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 662755003966 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 662755003967 ligand binding site [chemical binding]; other site 662755003968 flexible hinge region; other site 662755003969 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain...; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 662755003970 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 662755003971 metal binding triad; other site 662755003972 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 662755003973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 662755003974 Integrase core domain; Region: rve; cl01316 662755003975 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 662755003976 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755003977 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 662755003978 Walker A/P-loop; other site 662755003979 ATP binding site [chemical binding]; other site 662755003980 Q-loop/lid; other site 662755003981 ABC transporter signature motif; other site 662755003982 Walker B; other site 662755003983 D-loop; other site 662755003984 H-loop/switch region; other site 662755003985 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 662755003986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755003987 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 662755003988 putative L-serine binding site [chemical binding]; other site 662755003989 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 662755003990 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 662755003991 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 662755003992 proline/glycine betaine transporter; Provisional; Region: PRK10642 662755003993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755003994 putative substrate translocation pore; other site 662755003995 ketol-acid reductoisomerase; Provisional; Region: PRK05479 662755003996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755003997 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 662755003998 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 662755003999 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 662755004000 putative valine binding site [chemical binding]; other site 662755004001 dimer interface [polypeptide binding]; other site 662755004002 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 662755004003 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 662755004004 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 662755004005 PYR/PP interface [polypeptide binding]; other site 662755004006 dimer interface [polypeptide binding]; other site 662755004007 TPP binding site [chemical binding]; other site 662755004008 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 662755004009 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 662755004010 TPP-binding site [chemical binding]; other site 662755004011 dimer interface [polypeptide binding]; other site 662755004012 Mechanosensitive ion channel; Region: MS_channel; pfam00924 662755004013 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 662755004014 Dehydratase family; Region: ILVD_EDD; cl00340 662755004015 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 662755004016 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 662755004017 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 662755004018 putative dimer interface [polypeptide binding]; other site 662755004019 N-terminal domain interface [polypeptide binding]; other site 662755004020 putative substrate binding pocket (H-site) [chemical binding]; other site 662755004021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755004022 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 662755004023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 662755004024 dimerization interface [polypeptide binding]; other site 662755004025 LysE type translocator; Region: LysE; cl00565 662755004026 LysE type translocator; Region: LysE; cl00565 662755004027 DoxX; Region: DoxX; cl00976 662755004028 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 662755004029 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 662755004030 GatB domain; Region: GatB_Yqey; cl11497 662755004031 6-phosphofructokinase; Provisional; Region: PRK03202 662755004032 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 662755004033 active site 662755004034 ADP/pyrophosphate binding site [chemical binding]; other site 662755004035 dimerization interface [polypeptide binding]; other site 662755004036 allosteric effector site; other site 662755004037 fructose-1,6-bisphosphate binding site; other site 662755004038 putative transporter; Provisional; Region: PRK10504 662755004039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755004040 putative substrate translocation pore; other site 662755004041 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 662755004042 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 662755004043 nudix motif; other site 662755004044 nudix motif; other site 662755004045 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 662755004046 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 662755004047 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 662755004048 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 662755004049 threonine dehydratase; Reviewed; Region: PRK09224 662755004050 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 662755004051 tetramer interface [polypeptide binding]; other site 662755004052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755004053 catalytic residue [active] 662755004054 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 662755004055 putative Ile/Val binding site [chemical binding]; other site 662755004056 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 662755004057 putative Ile/Val binding site [chemical binding]; other site 662755004058 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 662755004059 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 662755004060 active site 662755004061 catalytic site [active] 662755004062 substrate binding site [chemical binding]; other site 662755004063 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 662755004064 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 662755004065 Walker A/P-loop; other site 662755004066 ATP binding site [chemical binding]; other site 662755004067 Q-loop/lid; other site 662755004068 ABC transporter signature motif; other site 662755004069 Walker B; other site 662755004070 D-loop; other site 662755004071 H-loop/switch region; other site 662755004072 Histidine kinase; Region: HisKA_3; pfam07730 662755004073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 662755004074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 662755004075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755004076 active site 662755004077 phosphorylation site [posttranslational modification] 662755004078 intermolecular recognition site; other site 662755004079 dimerization interface [polypeptide binding]; other site 662755004080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 662755004081 DNA binding residues [nucleotide binding] 662755004082 dimerization interface [polypeptide binding]; other site 662755004083 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 662755004084 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 662755004085 nucleotide binding pocket [chemical binding]; other site 662755004086 K-X-D-G motif; other site 662755004087 catalytic site [active] 662755004088 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 662755004089 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 662755004090 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 662755004091 Dimer interface [polypeptide binding]; other site 662755004092 BRCT sequence motif; other site 662755004093 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 662755004094 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 662755004095 Ligand Binding Site [chemical binding]; other site 662755004096 Protein of unknown function, DUF393; Region: DUF393; cl01136 662755004097 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 662755004098 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 662755004099 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 662755004100 catalytic residue [active] 662755004101 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 662755004102 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 662755004103 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 662755004104 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 662755004105 Ligand Binding Site [chemical binding]; other site 662755004106 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 662755004107 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 662755004108 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 662755004109 Ligand binding site [chemical binding]; other site 662755004110 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 662755004111 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755004112 Walker A/P-loop; other site 662755004113 ATP binding site [chemical binding]; other site 662755004114 Q-loop/lid; other site 662755004115 ABC transporter signature motif; other site 662755004116 Walker B; other site 662755004117 D-loop; other site 662755004118 H-loop/switch region; other site 662755004119 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 662755004120 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 662755004121 glycogen branching enzyme; Provisional; Region: PRK05402 662755004122 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 662755004123 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 662755004124 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 662755004125 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 662755004126 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 662755004127 Protein of unknown function DUF91; Region: DUF91; cl00709 662755004128 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 662755004129 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 662755004130 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 662755004131 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 662755004132 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 662755004133 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 662755004134 alpha subunit interaction interface [polypeptide binding]; other site 662755004135 Walker A motif; other site 662755004136 ATP binding site [chemical binding]; other site 662755004137 Walker B motif; other site 662755004138 inhibitor binding site; inhibition site 662755004139 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 662755004140 ATP synthase; Region: ATP-synt; cl00365 662755004141 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 662755004142 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 662755004143 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 662755004144 beta subunit interaction interface [polypeptide binding]; other site 662755004145 Walker A motif; other site 662755004146 ATP binding site [chemical binding]; other site 662755004147 Walker B motif; other site 662755004148 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 662755004149 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 662755004150 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 662755004151 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 662755004152 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 662755004153 ATP synthase subunit C; Region: ATP-synt_C; cl00466 662755004154 ATP synthase A chain; Region: ATP-synt_A; cl00413 662755004155 Protein of unknown function (DUF421); Region: DUF421; cl00990 662755004156 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 662755004157 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 662755004158 Mg++ binding site [ion binding]; other site 662755004159 putative catalytic motif [active] 662755004160 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 662755004161 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 662755004162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 662755004163 S-adenosylmethionine binding site [chemical binding]; other site 662755004164 peptide chain release factor 1; Validated; Region: prfA; PRK00591 662755004165 RF-1 domain; Region: RF-1; cl02875 662755004166 RF-1 domain; Region: RF-1; cl02875 662755004167 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 662755004168 transcription termination factor Rho; Provisional; Region: PRK12608 662755004169 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 662755004170 RNA binding site [nucleotide binding]; other site 662755004171 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 662755004172 multimer interface [polypeptide binding]; other site 662755004173 Walker A motif; other site 662755004174 ATP binding site [chemical binding]; other site 662755004175 Walker B motif; other site 662755004176 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 662755004177 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755004178 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 662755004179 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 662755004180 homoserine kinase; Provisional; Region: PRK01212 662755004181 homoserine dehydrogenase; Provisional; Region: PRK06349 662755004182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755004183 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 662755004184 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 662755004185 diaminopimelate decarboxylase; Region: lysA; TIGR01048 662755004186 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 662755004187 active site 662755004188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 662755004189 substrate binding site [chemical binding]; other site 662755004190 catalytic residues [active] 662755004191 dimer interface [polypeptide binding]; other site 662755004192 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 662755004193 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 662755004194 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 662755004195 active site 662755004196 HIGH motif; other site 662755004197 KMSK motif region; other site 662755004198 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 662755004199 tRNA binding surface [nucleotide binding]; other site 662755004200 anticodon binding site; other site 662755004201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755004202 cell division protein MukB; Provisional; Region: mukB; PRK04863 662755004203 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 662755004204 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 662755004205 active site 662755004206 metal binding site [ion binding]; metal-binding site 662755004207 DNA binding site [nucleotide binding] 662755004208 Uncharacterized conserved protein [Function unknown]; Region: COG4279 662755004209 SNF2 Helicase protein; Region: DUF3670; pfam12419 662755004210 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 662755004211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755004212 ATP binding site [chemical binding]; other site 662755004213 putative Mg++ binding site [ion binding]; other site 662755004214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755004215 nucleotide binding region [chemical binding]; other site 662755004216 ATP-binding site [chemical binding]; other site 662755004217 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 662755004218 Sodium:solute symporter family; Region: SSF; cl00456 662755004219 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 662755004220 helicase 45; Provisional; Region: PTZ00424 662755004221 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 662755004222 ATP binding site [chemical binding]; other site 662755004223 Mg++ binding site [ion binding]; other site 662755004224 motif III; other site 662755004225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755004226 nucleotide binding region [chemical binding]; other site 662755004227 ATP-binding site [chemical binding]; other site 662755004228 DbpA RNA binding domain; Region: DbpA; pfam03880 662755004229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755004230 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 662755004231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755004232 substrate binding pocket [chemical binding]; other site 662755004233 catalytic triad [active] 662755004234 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 662755004235 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 662755004236 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 662755004237 TPP-binding site [chemical binding]; other site 662755004238 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 662755004239 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 662755004240 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 662755004241 Domain of unknown function DUF59; Region: DUF59; cl00941 662755004242 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 662755004243 sec-independent translocase; Provisional; Region: tatB; PRK00182 662755004244 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 662755004245 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 662755004246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 662755004247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 662755004248 DNA binding residues [nucleotide binding] 662755004249 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 662755004250 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 662755004251 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 662755004252 ligand binding site [chemical binding]; other site 662755004253 oligomer interface [polypeptide binding]; other site 662755004254 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 662755004255 dimer interface [polypeptide binding]; other site 662755004256 N-terminal domain interface [polypeptide binding]; other site 662755004257 sulfate 1 binding site; other site 662755004258 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 662755004259 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 662755004260 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 662755004261 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 662755004262 active site 662755004263 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 662755004264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 662755004265 S-adenosylmethionine binding site [chemical binding]; other site 662755004266 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 662755004267 interface (dimer of trimers) [polypeptide binding]; other site 662755004268 Substrate-binding/catalytic site; other site 662755004269 Zn-binding sites [ion binding]; other site 662755004270 DivIVA domain; Region: DivI1A_domain; TIGR03544 662755004271 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 662755004272 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 662755004273 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 662755004274 metal binding site [ion binding]; metal-binding site 662755004275 putative dimer interface [polypeptide binding]; other site 662755004276 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 662755004277 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 662755004278 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 662755004279 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 662755004280 putative trimer interface [polypeptide binding]; other site 662755004281 putative CoA binding site [chemical binding]; other site 662755004282 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 662755004283 active site 662755004284 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 662755004285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 662755004286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755004287 homodimer interface [polypeptide binding]; other site 662755004288 catalytic residue [active] 662755004289 Ferredoxin [Energy production and conversion]; Region: COG1146 662755004290 4Fe-4S binding domain; Region: Fer4; cl02805 662755004291 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 662755004292 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 662755004293 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 662755004294 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 662755004295 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 662755004296 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 662755004297 G1 box; other site 662755004298 putative GEF interaction site [polypeptide binding]; other site 662755004299 GTP/Mg2+ binding site [chemical binding]; other site 662755004300 Switch I region; other site 662755004301 G2 box; other site 662755004302 G3 box; other site 662755004303 Switch II region; other site 662755004304 G4 box; other site 662755004305 G5 box; other site 662755004306 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 662755004307 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 662755004308 Uncharacterised protein family (UPF0253); Region: UPF0253; cl11640 662755004309 Protein of unknown function (DUF402); Region: DUF402; cl00979 662755004310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755004311 NAD(P) binding site [chemical binding]; other site 662755004312 active site 662755004313 Excalibur calcium-binding domain; Region: Excalibur; cl05460 662755004314 Integrase core domain; Region: rve; cl01316 662755004315 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 662755004316 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 662755004317 active site 662755004318 Cutinase; Region: Cutinase; pfam01083 662755004319 Protein of unknown function (DUF808); Region: DUF808; cl01002 662755004320 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 662755004321 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 662755004322 active site 662755004323 nucleophile elbow; other site 662755004324 Chlorite dismutase; Region: Chlor_dismutase; cl01280 662755004325 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 662755004326 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 662755004327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755004328 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 662755004329 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 662755004330 Walker A/P-loop; other site 662755004331 ATP binding site [chemical binding]; other site 662755004332 Q-loop/lid; other site 662755004333 ABC transporter signature motif; other site 662755004334 Walker B; other site 662755004335 D-loop; other site 662755004336 H-loop/switch region; other site 662755004337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755004338 Walker A/P-loop; other site 662755004339 ATP binding site [chemical binding]; other site 662755004340 Q-loop/lid; other site 662755004341 ABC transporter signature motif; other site 662755004342 Walker B; other site 662755004343 D-loop; other site 662755004344 H-loop/switch region; other site 662755004345 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 662755004346 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 662755004347 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755004348 Walker A/P-loop; other site 662755004349 ATP binding site [chemical binding]; other site 662755004350 Q-loop/lid; other site 662755004351 ABC transporter signature motif; other site 662755004352 Walker B; other site 662755004353 D-loop; other site 662755004354 H-loop/switch region; other site 662755004355 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 662755004356 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 662755004357 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755004358 Walker A/P-loop; other site 662755004359 ATP binding site [chemical binding]; other site 662755004360 Q-loop/lid; other site 662755004361 ABC transporter signature motif; other site 662755004362 Walker B; other site 662755004363 D-loop; other site 662755004364 H-loop/switch region; other site 662755004365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755004366 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 662755004367 putative substrate translocation pore; other site 662755004368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 662755004369 S-adenosylmethionine binding site [chemical binding]; other site 662755004370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 662755004371 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 662755004372 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 662755004373 dimerization interface [polypeptide binding]; other site 662755004374 putative DNA binding site [nucleotide binding]; other site 662755004375 putative Zn2+ binding site [ion binding]; other site 662755004376 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 662755004377 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 662755004378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755004379 Protein of unknown function DUF2625; Region: DUF2625; cl08177 662755004380 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 662755004381 RF-1 domain; Region: RF-1; cl02875 662755004382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 662755004383 salt bridge; other site 662755004384 non-specific DNA binding site [nucleotide binding]; other site 662755004385 sequence-specific DNA binding site [nucleotide binding]; other site 662755004386 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 662755004387 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 662755004388 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 662755004389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755004390 ATP binding site [chemical binding]; other site 662755004391 putative Mg++ binding site [ion binding]; other site 662755004392 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 662755004393 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 662755004394 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 662755004395 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 662755004396 Integrase core domain; Region: rve; cl01316 662755004397 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 662755004398 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 662755004399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755004400 ABC-ATPase subunit interface; other site 662755004401 dimer interface [polypeptide binding]; other site 662755004402 putative PBP binding regions; other site 662755004403 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 662755004404 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 662755004405 intersubunit interface [polypeptide binding]; other site 662755004406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 662755004407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 662755004408 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 662755004409 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 662755004410 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 662755004411 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 662755004412 Walker A/P-loop; other site 662755004413 ATP binding site [chemical binding]; other site 662755004414 Q-loop/lid; other site 662755004415 ABC transporter signature motif; other site 662755004416 Walker B; other site 662755004417 D-loop; other site 662755004418 H-loop/switch region; other site 662755004419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755004420 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 662755004421 Walker A/P-loop; other site 662755004422 ATP binding site [chemical binding]; other site 662755004423 Q-loop/lid; other site 662755004424 ABC transporter signature motif; other site 662755004425 Walker B; other site 662755004426 D-loop; other site 662755004427 H-loop/switch region; other site 662755004428 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 662755004429 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 662755004430 FAD binding pocket [chemical binding]; other site 662755004431 FAD binding motif [chemical binding]; other site 662755004432 phosphate binding motif [ion binding]; other site 662755004433 NAD binding pocket [chemical binding]; other site 662755004434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755004435 putative substrate translocation pore; other site 662755004436 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 662755004437 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 662755004438 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 662755004439 DNA binding residues [nucleotide binding] 662755004440 dimer interface [polypeptide binding]; other site 662755004441 [2Fe-2S] cluster binding site [ion binding]; other site 662755004442 HsdM N-terminal domain; Region: HsdM_N; pfam12161 662755004443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 662755004444 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 662755004445 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 662755004446 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 662755004447 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 662755004448 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 662755004449 active site 662755004450 DNA binding site [nucleotide binding] 662755004451 catalytic site [active] 662755004452 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 662755004453 BRO family, N-terminal domain; Region: Bro-N; cl10591 662755004454 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 662755004455 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 662755004456 D5 N terminal like; Region: D5_N; cl07360 662755004457 C-terminal domain; Region: primase_Cterm; TIGR01613 662755004458 VRR-NUC domain; Region: VRR_NUC; cl08494 662755004459 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 662755004460 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755004461 ATP binding site [chemical binding]; other site 662755004462 putative Mg++ binding site [ion binding]; other site 662755004463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 662755004464 Phage terminase, small subunit; Region: Terminase_4; cl01525 662755004465 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 662755004466 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 662755004467 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 662755004468 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 662755004469 ParB-like nuclease domain; Region: ParBc; cl02129 662755004470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755004471 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 662755004472 Phage Terminase; Region: Terminase_1; pfam03354 662755004473 Phage-related protein [Function unknown]; Region: COG4695; cl01923 662755004474 Phage portal protein; Region: Phage_portal; pfam04860 662755004475 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 662755004476 oligomer interface [polypeptide binding]; other site 662755004477 active site residues [active] 662755004478 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 662755004479 Phage capsid family; Region: Phage_capsid; pfam05065 662755004480 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 662755004481 oligomerization interface [polypeptide binding]; other site 662755004482 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 662755004483 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 662755004484 Phage-related minor tail protein [Function unknown]; Region: COG5280 662755004485 Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192 662755004486 Phage-related protein [Function unknown]; Region: COG5412 662755004487 Phage tail protein; Region: Sipho_tail; cl11462 662755004488 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 662755004489 gp58-like protein; Region: Gp58; pfam07902 662755004490 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 662755004491 Holin family; Region: Phage_holin_4; cl01989 662755004492 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 662755004493 amidase catalytic site [active] 662755004494 Zn binding residues [ion binding]; other site 662755004495 substrate binding site [chemical binding]; other site 662755004496 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 662755004497 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 662755004498 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 662755004499 catalytic residues [active] 662755004500 catalytic nucleophile [active] 662755004501 Recombinase; Region: Recombinase; pfam07508 662755004502 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 662755004503 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 662755004504 catalytic residues [active] 662755004505 catalytic nucleophile [active] 662755004506 Recombinase; Region: Recombinase; pfam07508 662755004507 Peptidase S46; Region: Peptidase_S46; pfam10459 662755004508 HsdM N-terminal domain; Region: HsdM_N; pfam12161 662755004509 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 662755004510 GTP-binding protein YchF; Reviewed; Region: PRK09601 662755004511 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 662755004512 G1 box; other site 662755004513 GTP/Mg2+ binding site [chemical binding]; other site 662755004514 Switch I region; other site 662755004515 G2 box; other site 662755004516 Switch II region; other site 662755004517 G3 box; other site 662755004518 G4 box; other site 662755004519 G5 box; other site 662755004520 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 662755004521 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 662755004522 Domain of unknown function DUF20; Region: UPF0118; cl00465 662755004523 LytB protein; Region: LYTB; cl00507 662755004524 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 662755004525 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 662755004526 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 662755004527 generic binding surface II; other site 662755004528 generic binding surface I; other site 662755004529 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 662755004530 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 662755004531 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 662755004532 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 662755004533 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 662755004534 putative active site [active] 662755004535 fumarate hydratase; Reviewed; Region: fumC; PRK00485 662755004536 Class II fumarases; Region: Fumarase_classII; cd01362 662755004537 active site 662755004538 tetramer interface [polypeptide binding]; other site 662755004539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 662755004540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 662755004541 Major Facilitator Superfamily; Region: MFS_1; pfam07690 662755004542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755004543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755004544 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 662755004545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 662755004546 Coenzyme A binding pocket [chemical binding]; other site 662755004547 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 662755004548 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 662755004549 putative active site [active] 662755004550 PhoH-like protein; Region: PhoH; cl12134 662755004551 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 662755004552 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 662755004553 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 662755004554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 662755004555 active site 662755004556 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 662755004557 putative homotetramer interface [polypeptide binding]; other site 662755004558 putative homodimer interface [polypeptide binding]; other site 662755004559 putative allosteric switch controlling residues; other site 662755004560 putative metal binding site [ion binding]; other site 662755004561 putative homodimer-homodimer interface [polypeptide binding]; other site 662755004562 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 662755004563 enoyl-CoA hydratase; Provisional; Region: PRK06688 662755004564 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 662755004565 substrate binding site [chemical binding]; other site 662755004566 oxyanion hole (OAH) forming residues; other site 662755004567 trimer interface [polypeptide binding]; other site 662755004568 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 662755004569 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 662755004570 dimer interface [polypeptide binding]; other site 662755004571 glycine-pyridoxal phosphate binding site [chemical binding]; other site 662755004572 active site 662755004573 folate binding site [chemical binding]; other site 662755004574 pantothenate kinase; Provisional; Region: PRK05439 662755004575 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 662755004576 ATP-binding site [chemical binding]; other site 662755004577 CoA-binding site [chemical binding]; other site 662755004578 Mg2+-binding site [ion binding]; other site 662755004579 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 662755004580 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 662755004581 catalytic residue [active] 662755004582 putative FPP diphosphate binding site; other site 662755004583 putative FPP binding hydrophobic cleft; other site 662755004584 dimer interface [polypeptide binding]; other site 662755004585 putative IPP diphosphate binding site; other site 662755004586 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 662755004587 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 662755004588 domain; Region: GreA_GreB_N; pfam03449 662755004589 C-term; Region: GreA_GreB; pfam01272 662755004590 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 662755004591 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 662755004592 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 662755004593 NAD(P) binding site [chemical binding]; other site 662755004594 catalytic residues [active] 662755004595 short chain dehydrogenase; Provisional; Region: PRK08219 662755004596 classical (c) SDRs; Region: SDR_c; cd05233 662755004597 NAD(P) binding site [chemical binding]; other site 662755004598 active site 662755004599 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 662755004600 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 662755004601 putative substrate binding site [chemical binding]; other site 662755004602 putative ATP binding site [chemical binding]; other site 662755004603 Protein of unknown function (DUF501); Region: DUF501; cl00652 662755004604 exopolyphosphatase; Region: exo_poly_only; TIGR03706 662755004605 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 662755004606 Septum formation initiator; Region: DivIC; cl11433 662755004607 enolase; Provisional; Region: eno; PRK00077 662755004608 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 662755004609 dimer interface [polypeptide binding]; other site 662755004610 metal binding site [ion binding]; metal-binding site 662755004611 substrate binding pocket [chemical binding]; other site 662755004612 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 662755004613 N-acetyl-D-glucosamine binding site [chemical binding]; other site 662755004614 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 662755004615 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 662755004616 FeoA domain; Region: FeoA; cl00838 662755004617 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 662755004618 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 662755004619 metal binding site [ion binding]; metal-binding site 662755004620 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 662755004621 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 662755004622 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755004623 ABC-ATPase subunit interface; other site 662755004624 dimer interface [polypeptide binding]; other site 662755004625 putative PBP binding regions; other site 662755004626 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 662755004627 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 662755004628 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 662755004629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755004630 ATP binding site [chemical binding]; other site 662755004631 putative Mg++ binding site [ion binding]; other site 662755004632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755004633 nucleotide binding region [chemical binding]; other site 662755004634 ATP-binding site [chemical binding]; other site 662755004635 TRCF domain; Region: TRCF; cl04088 662755004636 MULE transposase domain; Region: MULE; pfam10551 662755004637 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755004638 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 662755004639 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 662755004640 Substrate binding site [chemical binding]; other site 662755004641 Mg++ binding site [ion binding]; other site 662755004642 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 662755004643 active site 662755004644 substrate binding site [chemical binding]; other site 662755004645 CoA binding site [chemical binding]; other site 662755004646 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 662755004647 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 662755004648 Domain of unknown function DUF20; Region: UPF0118; cl00465 662755004649 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 662755004650 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 662755004651 5S rRNA interface [nucleotide binding]; other site 662755004652 CTC domain interface [polypeptide binding]; other site 662755004653 L16 interface [polypeptide binding]; other site 662755004654 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 662755004655 putative active site [active] 662755004656 catalytic residue [active] 662755004657 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 662755004658 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 662755004659 G1 box; other site 662755004660 putative GEF interaction site [polypeptide binding]; other site 662755004661 GTP/Mg2+ binding site [chemical binding]; other site 662755004662 Switch I region; other site 662755004663 G2 box; other site 662755004664 G3 box; other site 662755004665 Switch II region; other site 662755004666 G4 box; other site 662755004667 G5 box; other site 662755004668 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 662755004669 hydroperoxidase II; Provisional; Region: katE; PRK11249 662755004670 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 662755004671 heme binding pocket [chemical binding]; other site 662755004672 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 662755004673 domain interactions; other site 662755004674 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 662755004675 putative active site [active] 662755004676 catalytic residue [active] 662755004677 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 662755004678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 662755004679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 662755004680 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 662755004681 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 662755004682 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 662755004683 substrate binding site [chemical binding]; other site 662755004684 oxyanion hole (OAH) forming residues; other site 662755004685 trimer interface [polypeptide binding]; other site 662755004686 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 662755004687 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 662755004688 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 662755004689 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 662755004690 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 662755004691 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 662755004692 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755004693 Walker A/P-loop; other site 662755004694 ATP binding site [chemical binding]; other site 662755004695 Q-loop/lid; other site 662755004696 ABC transporter signature motif; other site 662755004697 Walker B; other site 662755004698 D-loop; other site 662755004699 H-loop/switch region; other site 662755004700 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 662755004701 Mnd1 family; Region: Mnd1; pfam03962 662755004702 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 662755004703 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 662755004704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 662755004705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 662755004706 Domain of unknown function (DUF348); Region: DUF348; pfam03990 662755004707 Domain of unknown function (DUF348); Region: DUF348; pfam03990 662755004708 Domain of unknown function (DUF348); Region: DUF348; pfam03990 662755004709 G5 domain; Region: G5; pfam07501 662755004710 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 662755004711 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 662755004712 active site 662755004713 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 662755004714 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 662755004715 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 662755004716 active site 662755004717 HIGH motif; other site 662755004718 KMSKS motif; other site 662755004719 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 662755004720 tRNA binding surface [nucleotide binding]; other site 662755004721 anticodon binding site; other site 662755004722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755004723 BCCT family transporter; Region: BCCT; cl00569 662755004724 Predicted methyltransferases [General function prediction only]; Region: COG0313 662755004725 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 662755004726 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 662755004727 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 662755004728 Predicted integral membrane protein [Function unknown]; Region: COG5660 662755004729 DoxX; Region: DoxX; cl00976 662755004730 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 662755004731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 662755004732 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 662755004733 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 662755004734 dimer interface [polypeptide binding]; other site 662755004735 putative functional site; other site 662755004736 putative MPT binding site; other site 662755004737 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 662755004738 active site 662755004739 tetramer interface [polypeptide binding]; other site 662755004740 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 662755004741 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 662755004742 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 662755004743 MPT binding site; other site 662755004744 trimer interface [polypeptide binding]; other site 662755004745 polyadenylate binding protein, human types 1, 2, 3, 4 family; Region: PABP-1234; TIGR01628 662755004746 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 662755004747 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 662755004748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 662755004749 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 662755004750 dimerization interface [polypeptide binding]; other site 662755004751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 662755004752 dimer interface [polypeptide binding]; other site 662755004753 phosphorylation site [posttranslational modification] 662755004754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 662755004755 ATP binding site [chemical binding]; other site 662755004756 G-X-G motif; other site 662755004757 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 662755004758 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 662755004759 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 662755004760 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 662755004761 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 662755004762 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 662755004763 RDD family; Region: RDD; cl00746 662755004764 Membrane transport protein; Region: Mem_trans; cl09117 662755004765 putative acyltransferase; Provisional; Region: PRK05790 662755004766 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 662755004767 dimer interface [polypeptide binding]; other site 662755004768 active site 662755004769 AMP-binding domain protein; Validated; Region: PRK08315 662755004770 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755004771 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 662755004772 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 662755004773 putative active site [active] 662755004774 putative catalytic site [active] 662755004775 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 662755004776 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 662755004777 active site 662755004778 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 662755004779 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 662755004780 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 662755004781 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 662755004782 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 662755004783 carboxyltransferase (CT) interaction site; other site 662755004784 biotinylation site [posttranslational modification]; other site 662755004785 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 662755004786 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 662755004787 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 662755004788 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 662755004789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 662755004790 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 662755004791 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 662755004792 purine monophosphate binding site [chemical binding]; other site 662755004793 dimer interface [polypeptide binding]; other site 662755004794 putative catalytic residues [active] 662755004795 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 662755004796 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 662755004797 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 662755004798 active site 662755004799 substrate binding site [chemical binding]; other site 662755004800 cosubstrate binding site; other site 662755004801 catalytic site [active] 662755004802 Peptidase family M23; Region: Peptidase_M23; pfam01551 662755004803 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 662755004804 UvrD/REP helicase; Region: UvrD-helicase; cl14126 662755004805 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 662755004806 Chorismate mutase type II; Region: CM_2; cl00693 662755004807 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role...; Region: PAP2_acid_phosphatase; cd03397 662755004808 active site 662755004809 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 662755004810 Nucleoside recognition; Region: Gate; cl00486 662755004811 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 662755004812 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 662755004813 Integrase core domain; Region: rve; cl01316 662755004814 MULE transposase domain; Region: MULE; pfam10551 662755004815 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755004816 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 662755004817 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 662755004818 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 662755004819 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 662755004820 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 662755004821 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 662755004822 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 662755004823 UvrD/REP helicase; Region: UvrD-helicase; cl14126 662755004824 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 662755004825 HRDC domain; Region: HRDC; cl02578 662755004826 Ion channel; Region: Ion_trans_2; cl11596 662755004827 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 662755004828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755004829 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 662755004830 UvrD/REP helicase; Region: UvrD-helicase; cl14126 662755004831 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 662755004832 UvrD/REP helicase; Region: UvrD-helicase; cl14126 662755004833 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 662755004834 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 662755004835 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 662755004836 TIGR02569 family protein; Region: TIGR02569_actnb 662755004837 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 662755004838 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 662755004839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755004840 ATP binding site [chemical binding]; other site 662755004841 putative Mg++ binding site [ion binding]; other site 662755004842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755004843 nucleotide binding region [chemical binding]; other site 662755004844 ATP-binding site [chemical binding]; other site 662755004845 Transcription factor WhiB; Region: Whib; pfam02467 662755004846 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 662755004847 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 662755004848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 662755004849 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 662755004850 DNA binding residues [nucleotide binding] 662755004851 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 662755004852 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 662755004853 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 662755004854 hinge; other site 662755004855 active site 662755004856 Predicted GTPases [General function prediction only]; Region: COG1162 662755004857 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 662755004858 GTPase/OB domain interface [polypeptide binding]; other site 662755004859 GTPase/Zn-binding domain interface [polypeptide binding]; other site 662755004860 GTP/Mg2+ binding site [chemical binding]; other site 662755004861 G4 box; other site 662755004862 G5 box; other site 662755004863 G1 box; other site 662755004864 Switch I region; other site 662755004865 G2 box; other site 662755004866 G3 box; other site 662755004867 Switch II region; other site 662755004868 AzlC protein; Region: AzlC; cl00570 662755004869 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 662755004870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755004871 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 662755004872 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 662755004873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 662755004874 nucleotide binding region [chemical binding]; other site 662755004875 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 662755004876 30S subunit binding site; other site 662755004877 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 662755004878 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 662755004879 lipoprotein LpqB; Provisional; Region: PRK13616 662755004880 Sporulation and spore germination; Region: Germane; cl11253 662755004881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 662755004882 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 662755004883 dimerization interface [polypeptide binding]; other site 662755004884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 662755004885 dimer interface [polypeptide binding]; other site 662755004886 phosphorylation site [posttranslational modification] 662755004887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 662755004888 ATP binding site [chemical binding]; other site 662755004889 Mg2+ binding site [ion binding]; other site 662755004890 G-X-G motif; other site 662755004891 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 662755004892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755004893 active site 662755004894 phosphorylation site [posttranslational modification] 662755004895 intermolecular recognition site; other site 662755004896 dimerization interface [polypeptide binding]; other site 662755004897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 662755004898 DNA binding site [nucleotide binding] 662755004899 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 662755004900 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 662755004901 TMP-binding site; other site 662755004902 ATP-binding site [chemical binding]; other site 662755004903 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 662755004904 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 662755004905 active site 662755004906 NAD+ binding site [chemical binding]; other site 662755004907 oligomerization interface [polypeptide binding]; other site 662755004908 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 662755004909 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 662755004910 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 662755004911 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 662755004912 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 662755004913 active site 662755004914 substrate binding site [chemical binding]; other site 662755004915 metal binding site [ion binding]; metal-binding site 662755004916 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 662755004917 Transcription factor WhiB; Region: Whib; pfam02467 662755004918 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 662755004919 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 662755004920 active site 662755004921 Substrate binding site [chemical binding]; other site 662755004922 Mg++ binding site [ion binding]; other site 662755004923 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 662755004924 putative trimer interface [polypeptide binding]; other site 662755004925 putative CoA binding site [chemical binding]; other site 662755004926 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 662755004927 Probable Catalytic site [active] 662755004928 metal binding site [ion binding]; metal-binding site 662755004929 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 662755004930 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 662755004931 NADP binding site [chemical binding]; other site 662755004932 active site 662755004933 putative substrate binding site [chemical binding]; other site 662755004934 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 662755004935 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755004936 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 662755004937 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 662755004938 Walker A/P-loop; other site 662755004939 ATP binding site [chemical binding]; other site 662755004940 Q-loop/lid; other site 662755004941 ABC transporter signature motif; other site 662755004942 Walker B; other site 662755004943 D-loop; other site 662755004944 H-loop/switch region; other site 662755004945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 662755004946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755004947 active site 662755004948 phosphorylation site [posttranslational modification] 662755004949 intermolecular recognition site; other site 662755004950 dimerization interface [polypeptide binding]; other site 662755004951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 662755004952 DNA binding residues [nucleotide binding] 662755004953 dimerization interface [polypeptide binding]; other site 662755004954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 662755004955 Histidine kinase; Region: HisKA_3; pfam07730 662755004956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 662755004957 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 662755004958 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 662755004959 Walker A/P-loop; other site 662755004960 ATP binding site [chemical binding]; other site 662755004961 Q-loop/lid; other site 662755004962 ABC transporter signature motif; other site 662755004963 Walker B; other site 662755004964 D-loop; other site 662755004965 H-loop/switch region; other site 662755004966 TOBE domain; Region: TOBE_2; cl01440 662755004967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 662755004968 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 662755004969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755004970 dimer interface [polypeptide binding]; other site 662755004971 conserved gate region; other site 662755004972 putative PBP binding loops; other site 662755004973 ABC-ATPase subunit interface; other site 662755004974 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 662755004975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755004976 dimer interface [polypeptide binding]; other site 662755004977 conserved gate region; other site 662755004978 putative PBP binding loops; other site 662755004979 ABC-ATPase subunit interface; other site 662755004980 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 662755004981 putative active site [active] 662755004982 AIR carboxylase; Region: AIRC; cl00310 662755004983 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 662755004984 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 662755004985 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 662755004986 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 662755004987 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 662755004988 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 662755004989 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 662755004990 Maf-like protein; Region: Maf; pfam02545 662755004991 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 662755004992 active site 662755004993 dimer interface [polypeptide binding]; other site 662755004994 citrate synthase; Provisional; Region: PRK14033 662755004995 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA...; Region: DsCS_like; cd06111 662755004996 dimer interface [polypeptide binding]; other site 662755004997 active site 662755004998 citrylCoA binding site [chemical binding]; other site 662755004999 oxalacetate/citrate binding site [chemical binding]; other site 662755005000 coenzyme A binding site [chemical binding]; other site 662755005001 catalytic triad [active] 662755005002 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 662755005003 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 662755005004 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 662755005005 active site residue [active] 662755005006 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 662755005007 active site residue [active] 662755005008 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 662755005009 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 662755005010 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 662755005011 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 662755005012 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 662755005013 carboxyltransferase (CT) interaction site; other site 662755005014 biotinylation site [posttranslational modification]; other site 662755005015 potential frameshift: common BLAST hit: gi|68536761|ref|YP_251466.1| putative glycerol kinase 662755005016 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 662755005017 catalytic site [active] 662755005018 metal binding site [ion binding]; metal-binding site 662755005019 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 662755005020 N- and C-terminal domain interface [polypeptide binding]; other site 662755005021 active site 662755005022 carbohydrate binding site [chemical binding]; other site 662755005023 MgATP binding site [chemical binding]; other site 662755005024 metal binding site [ion binding]; metal-binding site 662755005025 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 662755005026 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 662755005027 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 662755005028 NAD(P) binding site [chemical binding]; other site 662755005029 catalytic residues [active] 662755005030 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 662755005031 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 662755005032 metal binding site [ion binding]; metal-binding site 662755005033 putative dimer interface [polypeptide binding]; other site 662755005034 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 662755005035 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 662755005036 active site 662755005037 substrate binding site [chemical binding]; other site 662755005038 metal binding site [ion binding]; metal-binding site 662755005039 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757 662755005040 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 662755005041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755005042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755005043 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 662755005044 NlpC/P60 family; Region: NLPC_P60; cl11438 662755005045 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 662755005046 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755005047 Walker A/P-loop; other site 662755005048 ATP binding site [chemical binding]; other site 662755005049 Q-loop/lid; other site 662755005050 ABC transporter signature motif; other site 662755005051 Walker B; other site 662755005052 D-loop; other site 662755005053 H-loop/switch region; other site 662755005054 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 662755005055 TM-ABC transporter signature motif; other site 662755005056 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 662755005057 putative ligand binding site [chemical binding]; other site 662755005058 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 662755005059 active site 662755005060 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 662755005061 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 662755005062 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 662755005063 active site 662755005064 HIGH motif; other site 662755005065 dimer interface [polypeptide binding]; other site 662755005066 KMSKS motif; other site 662755005067 hypothetical protein; Provisional; Region: PRK10578 662755005068 UPF0126 domain; Region: UPF0126; pfam03458 662755005069 UPF0126 domain; Region: UPF0126; pfam03458 662755005070 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 662755005071 putative catalytic site [active] 662755005072 putative metal binding site [ion binding]; other site 662755005073 putative phosphate binding site [ion binding]; other site 662755005074 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 662755005075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755005076 putative substrate translocation pore; other site 662755005077 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 662755005078 isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178 662755005079 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 662755005080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755005081 CoA-ligase; Region: Ligase_CoA; pfam00549 662755005082 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 662755005083 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 662755005084 CoA-ligase; Region: Ligase_CoA; pfam00549 662755005085 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 662755005086 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 662755005087 homodimer interface [polypeptide binding]; other site 662755005088 substrate-cofactor binding pocket; other site 662755005089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755005090 catalytic residue [active] 662755005091 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755005092 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 662755005093 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 662755005094 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 662755005095 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 662755005096 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 662755005097 homodimer interface [polypeptide binding]; other site 662755005098 NADP binding site [chemical binding]; other site 662755005099 substrate binding site [chemical binding]; other site 662755005100 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 662755005101 Uncharacterized conserved protein [Function unknown]; Region: COG3268 662755005102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755005103 NAD(P) binding pocket [chemical binding]; other site 662755005104 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 662755005105 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755005106 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755005107 Cobalt transport protein; Region: CbiQ; cl00463 662755005108 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 662755005109 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 662755005110 Walker A/P-loop; other site 662755005111 ATP binding site [chemical binding]; other site 662755005112 Q-loop/lid; other site 662755005113 ABC transporter signature motif; other site 662755005114 Walker B; other site 662755005115 D-loop; other site 662755005116 H-loop/switch region; other site 662755005117 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 662755005118 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 662755005119 Walker A/P-loop; other site 662755005120 ATP binding site [chemical binding]; other site 662755005121 Q-loop/lid; other site 662755005122 ABC transporter signature motif; other site 662755005123 Walker B; other site 662755005124 D-loop; other site 662755005125 H-loop/switch region; other site 662755005126 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 662755005127 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 662755005128 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 662755005129 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 662755005130 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 662755005131 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 662755005132 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 662755005133 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 662755005134 generic binding surface II; other site 662755005135 generic binding surface I; other site 662755005136 T5orf172 domain; Region: T5orf172; cl11176 662755005137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755005138 ATP binding site [chemical binding]; other site 662755005139 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 662755005140 putative Mg++ binding site [ion binding]; other site 662755005141 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 662755005142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 662755005143 non-specific DNA binding site [nucleotide binding]; other site 662755005144 salt bridge; other site 662755005145 sequence-specific DNA binding site [nucleotide binding]; other site 662755005146 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 662755005147 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 662755005148 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 662755005149 Walker A/P-loop; other site 662755005150 ATP binding site [chemical binding]; other site 662755005151 Q-loop/lid; other site 662755005152 ABC transporter signature motif; other site 662755005153 Walker B; other site 662755005154 D-loop; other site 662755005155 H-loop/switch region; other site 662755005156 NIL domain; Region: NIL; cl09633 662755005157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 662755005158 dimer interface [polypeptide binding]; other site 662755005159 conserved gate region; other site 662755005160 putative PBP binding loops; other site 662755005161 ABC-ATPase subunit interface; other site 662755005162 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 662755005163 putative dimer interface [polypeptide binding]; other site 662755005164 putative [2Fe-2S] cluster binding site [ion binding]; other site 662755005165 DNA Polymerase Y-family; Region: PolY_like; cd03468 662755005166 active site 662755005167 DNA binding site [nucleotide binding] 662755005168 GMP synthase; Reviewed; Region: guaA; PRK00074 662755005169 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 662755005170 AMP/PPi binding site [chemical binding]; other site 662755005171 candidate oxyanion hole; other site 662755005172 catalytic triad [active] 662755005173 potential glutamine specificity residues [chemical binding]; other site 662755005174 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 662755005175 ATP Binding subdomain [chemical binding]; other site 662755005176 Ligand Binding sites [chemical binding]; other site 662755005177 Dimerization subdomain; other site 662755005178 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 662755005179 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 662755005180 phosphate binding site [ion binding]; other site 662755005181 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 662755005182 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 662755005183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 662755005184 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 662755005185 active site 662755005186 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 662755005187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 662755005188 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 662755005189 DNA binding residues [nucleotide binding] 662755005190 Transcription factor WhiB; Region: Whib; pfam02467 662755005191 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 662755005192 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 662755005193 ring oligomerisation interface [polypeptide binding]; other site 662755005194 ATP/Mg binding site [chemical binding]; other site 662755005195 stacking interactions; other site 662755005196 hinge regions; other site 662755005197 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 662755005198 oligomerisation interface [polypeptide binding]; other site 662755005199 mobile loop; other site 662755005200 roof hairpin; other site 662755005201 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 662755005202 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 662755005203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 662755005204 Coenzyme A binding pocket [chemical binding]; other site 662755005205 UGMP family protein; Validated; Region: PRK09604 662755005206 alanine racemase; Reviewed; Region: alr; PRK00053 662755005207 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 662755005208 active site 662755005209 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 662755005210 dimer interface [polypeptide binding]; other site 662755005211 substrate binding site [chemical binding]; other site 662755005212 catalytic residues [active] 662755005213 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 662755005214 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 662755005215 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 662755005216 glutaminase active site [active] 662755005217 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 662755005218 dimer interface [polypeptide binding]; other site 662755005219 active site 662755005220 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 662755005221 dimer interface [polypeptide binding]; other site 662755005222 active site 662755005223 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 662755005224 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 662755005225 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 662755005226 active site 662755005227 substrate binding site [chemical binding]; other site 662755005228 metal binding site [ion binding]; metal-binding site 662755005229 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 662755005230 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 662755005231 23S rRNA interface [nucleotide binding]; other site 662755005232 L3 interface [polypeptide binding]; other site 662755005233 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 662755005234 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 662755005235 Proteins of 100 residues with WXG; Region: WXG100; cl02005 662755005236 Proteins of 100 residues with WXG; Region: WXG100; cl02005 662755005237 C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 662755005238 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 662755005239 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755005240 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 662755005241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755005242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755005243 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 662755005244 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 662755005245 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 662755005246 active site 662755005247 catalytic residues [active] 662755005248 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 662755005249 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 662755005250 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 662755005251 dimerization interface 3.5A [polypeptide binding]; other site 662755005252 active site 662755005253 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 662755005254 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 662755005255 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 662755005256 alphaNTD - beta interaction site [polypeptide binding]; other site 662755005257 alphaNTD homodimer interface [polypeptide binding]; other site 662755005258 alphaNTD - beta' interaction site [polypeptide binding]; other site 662755005259 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 662755005260 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 662755005261 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 662755005262 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 662755005263 RNA binding surface [nucleotide binding]; other site 662755005264 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 662755005265 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 662755005266 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 662755005267 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 662755005268 rRNA binding site [nucleotide binding]; other site 662755005269 predicted 30S ribosome binding site; other site 662755005270 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 662755005271 methionine aminopeptidase; Provisional; Region: PRK12318 662755005272 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 662755005273 active site 662755005274 adenylate kinase; Reviewed; Region: adk; PRK00279 662755005275 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 662755005276 AMP-binding site [chemical binding]; other site 662755005277 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 662755005278 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 662755005279 SecY translocase; Region: SecY; pfam00344 662755005280 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 662755005281 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 662755005282 23S rRNA binding site [nucleotide binding]; other site 662755005283 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 662755005284 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 662755005285 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 662755005286 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 662755005287 23S rRNA interface [nucleotide binding]; other site 662755005288 L21e interface [polypeptide binding]; other site 662755005289 5S rRNA interface [nucleotide binding]; other site 662755005290 L27 interface [polypeptide binding]; other site 662755005291 L5 interface [polypeptide binding]; other site 662755005292 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 662755005293 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 662755005294 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 662755005295 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 662755005296 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755005297 ABC-ATPase subunit interface; other site 662755005298 dimer interface [polypeptide binding]; other site 662755005299 putative PBP binding regions; other site 662755005300 Transposase; Region: DEDD_Tnp_IS110; pfam01548 662755005301 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 662755005302 multiple promoter invertase; Provisional; Region: mpi; PRK13413 662755005303 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 662755005304 catalytic residues [active] 662755005305 catalytic nucleophile [active] 662755005306 Presynaptic Site I dimer interface [polypeptide binding]; other site 662755005307 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 662755005308 Synaptic Flat tetramer interface [polypeptide binding]; other site 662755005309 Synaptic Site I dimer interface [polypeptide binding]; other site 662755005310 DNA binding site [nucleotide binding] 662755005311 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 662755005312 DNA-binding interface [nucleotide binding]; DNA binding site 662755005313 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 662755005314 active site 662755005315 ATP binding site [chemical binding]; other site 662755005316 substrate binding site [chemical binding]; other site 662755005317 activation loop (A-loop); other site 662755005318 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 662755005319 active site 662755005320 zinc binding site [ion binding]; other site 662755005321 FtsX-like permease family; Region: FtsX; pfam02687 662755005322 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 662755005323 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 662755005324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755005325 Walker A/P-loop; other site 662755005326 ATP binding site [chemical binding]; other site 662755005327 Q-loop/lid; other site 662755005328 ABC transporter signature motif; other site 662755005329 Walker B; other site 662755005330 D-loop; other site 662755005331 H-loop/switch region; other site 662755005332 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 662755005333 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 662755005334 Walker A/P-loop; other site 662755005335 ATP binding site [chemical binding]; other site 662755005336 Q-loop/lid; other site 662755005337 ABC transporter signature motif; other site 662755005338 Walker B; other site 662755005339 D-loop; other site 662755005340 H-loop/switch region; other site 662755005341 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755005342 ABC-ATPase subunit interface; other site 662755005343 dimer interface [polypeptide binding]; other site 662755005344 putative PBP binding regions; other site 662755005345 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 662755005346 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755005347 ABC-ATPase subunit interface; other site 662755005348 dimer interface [polypeptide binding]; other site 662755005349 putative PBP binding regions; other site 662755005350 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 662755005351 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 662755005352 siderophore binding site; other site 662755005353 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 662755005354 FAD binding pocket [chemical binding]; other site 662755005355 FAD binding motif [chemical binding]; other site 662755005356 phosphate binding motif [ion binding]; other site 662755005357 NAD binding pocket [chemical binding]; other site 662755005358 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 662755005359 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 662755005360 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 662755005361 KOW motif; Region: KOW; cl00354 662755005362 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 662755005363 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 662755005364 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 662755005365 putative translocon interaction site; other site 662755005366 signal recognition particle (SRP54) interaction site; other site 662755005367 L23 interface [polypeptide binding]; other site 662755005368 trigger factor interaction site; other site 662755005369 23S rRNA interface [nucleotide binding]; other site 662755005370 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 662755005371 23S rRNA interface [nucleotide binding]; other site 662755005372 5S rRNA interface [nucleotide binding]; other site 662755005373 putative antibiotic binding site [chemical binding]; other site 662755005374 L25 interface [polypeptide binding]; other site 662755005375 L27 interface [polypeptide binding]; other site 662755005376 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 662755005377 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 662755005378 G-X-X-G motif; other site 662755005379 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 662755005380 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 662755005381 putative translocon binding site; other site 662755005382 protein-rRNA interface [nucleotide binding]; other site 662755005383 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 662755005384 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 662755005385 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 662755005386 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 662755005387 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 662755005388 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 662755005389 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 662755005390 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 662755005391 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 662755005392 active site 662755005393 catalytic site [active] 662755005394 MULE transposase domain; Region: MULE; pfam10551 662755005395 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755005396 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 662755005397 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 662755005398 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 662755005399 putative homodimer interface [polypeptide binding]; other site 662755005400 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 662755005401 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 662755005402 23S rRNA interface [nucleotide binding]; other site 662755005403 L7/L12 interface [polypeptide binding]; other site 662755005404 putative thiostrepton binding site; other site 662755005405 L25 interface [polypeptide binding]; other site 662755005406 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 662755005407 mRNA/rRNA interface [nucleotide binding]; other site 662755005408 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 662755005409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 662755005410 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 662755005411 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 662755005412 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 662755005413 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 662755005414 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 662755005415 intersubunit interface [polypeptide binding]; other site 662755005416 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 662755005417 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 662755005418 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 662755005419 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 662755005420 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 662755005421 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 662755005422 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 662755005423 dimer interface [polypeptide binding]; other site 662755005424 ABC-ATPase subunit interface; other site 662755005425 putative PBP binding regions; other site 662755005426 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 662755005427 23S rRNA interface [nucleotide binding]; other site 662755005428 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 662755005429 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 662755005430 peripheral dimer interface [polypeptide binding]; other site 662755005431 core dimer interface [polypeptide binding]; other site 662755005432 L10 interface [polypeptide binding]; other site 662755005433 L11 interface [polypeptide binding]; other site 662755005434 putative EF-Tu interaction site [polypeptide binding]; other site 662755005435 putative EF-G interaction site [polypeptide binding]; other site 662755005436 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 662755005437 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 662755005438 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 662755005439 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 662755005440 RPB1 interaction site [polypeptide binding]; other site 662755005441 RPB10 interaction site [polypeptide binding]; other site 662755005442 RPB11 interaction site [polypeptide binding]; other site 662755005443 RPB3 interaction site [polypeptide binding]; other site 662755005444 RPB12 interaction site [polypeptide binding]; other site 662755005445 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 662755005446 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 662755005447 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 662755005448 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 662755005449 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 662755005450 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 662755005451 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 662755005452 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 662755005453 DNA binding site [nucleotide binding] 662755005454 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 662755005455 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 662755005456 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 662755005457 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 662755005458 S17 interaction site [polypeptide binding]; other site 662755005459 S8 interaction site; other site 662755005460 16S rRNA interaction site [nucleotide binding]; other site 662755005461 streptomycin interaction site [chemical binding]; other site 662755005462 23S rRNA interaction site [nucleotide binding]; other site 662755005463 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 662755005464 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 662755005465 elongation factor G; Reviewed; Region: PRK00007 662755005466 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 662755005467 G1 box; other site 662755005468 putative GEF interaction site [polypeptide binding]; other site 662755005469 GTP/Mg2+ binding site [chemical binding]; other site 662755005470 Switch I region; other site 662755005471 G2 box; other site 662755005472 G3 box; other site 662755005473 Switch II region; other site 662755005474 G4 box; other site 662755005475 G5 box; other site 662755005476 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 662755005477 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 662755005478 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 662755005479 elongation factor Tu; Reviewed; Region: PRK00049 662755005480 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 662755005481 G1 box; other site 662755005482 GEF interaction site [polypeptide binding]; other site 662755005483 GTP/Mg2+ binding site [chemical binding]; other site 662755005484 Switch I region; other site 662755005485 G2 box; other site 662755005486 G3 box; other site 662755005487 Switch II region; other site 662755005488 G4 box; other site 662755005489 G5 box; other site 662755005490 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 662755005491 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 662755005492 Antibiotic Binding Site [chemical binding]; other site 662755005493 MULE transposase domain; Region: MULE; pfam10551 662755005494 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755005495 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 662755005496 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 662755005497 substrate binding pocket [chemical binding]; other site 662755005498 chain length determination region; other site 662755005499 substrate-Mg2+ binding site; other site 662755005500 catalytic residues [active] 662755005501 aspartate-rich region 1; other site 662755005502 active site lid residues [active] 662755005503 aspartate-rich region 2; other site 662755005504 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 662755005505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755005506 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 662755005507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 662755005508 S-adenosylmethionine binding site [chemical binding]; other site 662755005509 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 662755005510 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 662755005511 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 662755005512 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 662755005513 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 662755005514 dimer interface [polypeptide binding]; other site 662755005515 tetramer interface [polypeptide binding]; other site 662755005516 PYR/PP interface [polypeptide binding]; other site 662755005517 TPP binding site [chemical binding]; other site 662755005518 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 662755005519 TPP-binding site; other site 662755005520 O-succinylbenzoate synthase; Provisional; Region: PRK02901 662755005521 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 662755005522 metal binding site [ion binding]; metal-binding site 662755005523 substrate binding pocket [chemical binding]; other site 662755005524 naphthoate synthase; Validated; Region: PRK08321 662755005525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 662755005526 substrate binding site [chemical binding]; other site 662755005527 oxyanion hole (OAH) forming residues; other site 662755005528 trimer interface [polypeptide binding]; other site 662755005529 DoxX; Region: DoxX; cl00976 662755005530 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755005531 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 662755005532 UbiA prenyltransferase family; Region: UbiA; cl00337 662755005533 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 662755005534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755005535 putative substrate translocation pore; other site 662755005536 VanZ like family; Region: VanZ; cl01971 662755005537 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 662755005538 active site 662755005539 ATP binding site [chemical binding]; other site 662755005540 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 662755005541 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 662755005542 substrate binding site [chemical binding]; other site 662755005543 tetramer interface [polypeptide binding]; other site 662755005544 Cupin domain; Region: Cupin_2; cl09118 662755005545 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 662755005546 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 662755005547 Walker A/P-loop; other site 662755005548 ATP binding site [chemical binding]; other site 662755005549 Q-loop/lid; other site 662755005550 ABC transporter signature motif; other site 662755005551 Walker B; other site 662755005552 D-loop; other site 662755005553 H-loop/switch region; other site 662755005554 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 662755005555 dimer interface [polypeptide binding]; other site 662755005556 putative PBP binding regions; other site 662755005557 ABC-ATPase subunit interface; other site 662755005558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 662755005559 Integrase core domain; Region: rve; cl01316 662755005560 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 662755005561 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 662755005562 NAD binding site [chemical binding]; other site 662755005563 substrate binding site [chemical binding]; other site 662755005564 homodimer interface [polypeptide binding]; other site 662755005565 active site 662755005566 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 662755005567 ResB-like family; Region: ResB; pfam05140 662755005568 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 662755005569 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 662755005570 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 662755005571 catalytic residues [active] 662755005572 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 662755005573 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 662755005574 catalytic core [active] 662755005575 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 662755005576 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 662755005577 inhibitor-cofactor binding pocket; inhibition site 662755005578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755005579 catalytic residue [active] 662755005580 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 662755005581 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 662755005582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755005583 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 662755005584 dimer interface [polypeptide binding]; other site 662755005585 active site 662755005586 Schiff base residues; other site 662755005587 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 662755005588 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 662755005589 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 662755005590 active site 662755005591 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 662755005592 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 662755005593 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 662755005594 domain interfaces; other site 662755005595 active site 662755005596 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 662755005597 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 662755005598 tRNA; other site 662755005599 putative tRNA binding site [nucleotide binding]; other site 662755005600 putative NADP binding site [chemical binding]; other site 662755005601 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 662755005602 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 662755005603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755005604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755005605 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 662755005606 exopolyphosphatase; Region: exo_poly_only; TIGR03706 662755005607 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 662755005608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 662755005609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755005610 active site 662755005611 phosphorylation site [posttranslational modification] 662755005612 intermolecular recognition site; other site 662755005613 dimerization interface [polypeptide binding]; other site 662755005614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 662755005615 DNA binding site [nucleotide binding] 662755005616 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 662755005617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 662755005618 dimer interface [polypeptide binding]; other site 662755005619 phosphorylation site [posttranslational modification] 662755005620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 662755005621 ATP binding site [chemical binding]; other site 662755005622 G-X-G motif; other site 662755005623 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 662755005624 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 662755005625 catalytic core [active] 662755005626 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 662755005627 Protein of unknown function (DUF2596); Region: DUF2596; pfam10770 662755005628 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 662755005629 active site 662755005630 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 662755005631 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 662755005632 putative ADP-binding pocket [chemical binding]; other site 662755005633 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 662755005634 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755005635 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755005636 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 662755005637 FAD binding domain; Region: FAD_binding_4; pfam01565 662755005638 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 662755005639 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 662755005640 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 662755005641 intersubunit interface [polypeptide binding]; other site 662755005642 active site 662755005643 catalytic residue [active] 662755005644 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 662755005645 Predicted membrane protein [Function unknown]; Region: COG2733 662755005646 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 662755005647 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 662755005648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755005649 domain; Region: Succ_DH_flav_C; pfam02910 662755005650 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 662755005651 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 662755005652 putative Iron-sulfur protein interface [polypeptide binding]; other site 662755005653 proximal heme binding site [chemical binding]; other site 662755005654 distal heme binding site [chemical binding]; other site 662755005655 putative dimer interface [polypeptide binding]; other site 662755005656 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 662755005657 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 662755005658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755005659 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 662755005660 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 662755005661 active site 662755005662 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 662755005663 tetramer interface [polypeptide binding]; other site 662755005664 active site 662755005665 Mg2+/Mn2+ binding site [ion binding]; other site 662755005666 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 662755005667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 662755005668 non-specific DNA binding site [nucleotide binding]; other site 662755005669 salt bridge; other site 662755005670 sequence-specific DNA binding site [nucleotide binding]; other site 662755005671 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 662755005672 Domain of unknown function (DUF955); Region: DUF955; cl01076 662755005673 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 662755005674 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 662755005675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755005676 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 662755005677 Predicted esterase [General function prediction only]; Region: COG0627 662755005678 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 662755005679 Zn binding site [ion binding]; other site 662755005680 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 662755005681 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 662755005682 active site 662755005683 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 662755005684 Ligand binding site [chemical binding]; other site 662755005685 Putative Catalytic site [active] 662755005686 DXD motif; other site 662755005687 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 662755005688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 662755005689 acyl-CoA oxidase; Region: PLN02312 662755005690 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 662755005691 active site 662755005692 diacylglycerol kinase; Reviewed; Region: PRK11914 662755005693 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 662755005694 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 662755005695 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 662755005696 FAD binding domain; Region: FAD_binding_4; pfam01565 662755005697 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 662755005698 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755005699 MULE transposase domain; Region: MULE; pfam10551 662755005700 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 662755005701 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 662755005702 putative acyl-acceptor binding pocket; other site 662755005703 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 662755005704 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 662755005705 Transcriptional regulators [Transcription]; Region: MarR; COG1846 662755005706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755005707 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755005708 MULE transposase domain; Region: MULE; pfam10551 662755005709 DNA polymerase III subunit delta'; Validated; Region: PRK07940 662755005710 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755005711 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 662755005712 dimerization interface [polypeptide binding]; other site 662755005713 cyclase homology domain; Region: CHD; cd07302 662755005714 nucleotidyl binding site; other site 662755005715 metal binding site [ion binding]; metal-binding site 662755005716 dimer interface [polypeptide binding]; other site 662755005717 CoA-transferase family III; Region: CoA_transf_3; cl00778 662755005718 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 662755005719 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 662755005720 active site 662755005721 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 662755005722 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 662755005723 active site 662755005724 interdomain interaction site; other site 662755005725 putative metal-binding site [ion binding]; other site 662755005726 nucleotide binding site [chemical binding]; other site 662755005727 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 662755005728 domain I; other site 662755005729 phosphate binding site [ion binding]; other site 662755005730 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 662755005731 domain II; other site 662755005732 domain III; other site 662755005733 nucleotide binding site [chemical binding]; other site 662755005734 DNA binding groove [nucleotide binding] 662755005735 catalytic site [active] 662755005736 domain IV; other site 662755005737 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 662755005738 DNA-binding site [nucleotide binding]; DNA binding site 662755005739 RNA-binding motif; other site 662755005740 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 662755005741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 662755005742 ATP binding site [chemical binding]; other site 662755005743 putative Mg++ binding site [ion binding]; other site 662755005744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755005745 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 662755005746 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 662755005747 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 662755005748 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 662755005749 ATP binding site [chemical binding]; other site 662755005750 Walker A motif; other site 662755005751 hexamer interface [polypeptide binding]; other site 662755005752 Walker B motif; other site 662755005753 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 662755005754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 662755005755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 662755005756 motif II; other site 662755005757 Fic/DOC family; Region: Fic; cl00960 662755005758 Fic family protein [Function unknown]; Region: COG3177 662755005759 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 662755005760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 662755005761 Colicin V production protein; Region: Colicin_V; cl00567 662755005762 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 662755005763 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 662755005764 putative active site [active] 662755005765 putative CoA binding site [chemical binding]; other site 662755005766 nudix motif; other site 662755005767 metal binding site [ion binding]; metal-binding site 662755005768 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 662755005769 catalytic residues [active] 662755005770 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 662755005771 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 662755005772 minor groove reading motif; other site 662755005773 helix-hairpin-helix signature motif; other site 662755005774 substrate binding pocket [chemical binding]; other site 662755005775 active site 662755005776 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 662755005777 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 662755005778 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 662755005779 ligand binding site [chemical binding]; other site 662755005780 flexible hinge region; other site 662755005781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755005782 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 662755005783 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 662755005784 homotrimer interaction site [polypeptide binding]; other site 662755005785 putative active site [active] 662755005786 Transcription factor WhiB; Region: Whib; pfam02467 662755005787 Transglycosylase; Region: Transgly; cl07896 662755005788 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 662755005789 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 662755005790 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 662755005791 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 662755005792 putative active site [active] 662755005793 putative metal binding site [ion binding]; other site 662755005794 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755005795 MULE transposase domain; Region: MULE; pfam10551 662755005796 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 662755005797 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 662755005798 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 662755005799 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 662755005800 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 662755005801 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 662755005802 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 662755005803 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 662755005804 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 662755005805 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 662755005806 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 662755005807 OsmC-like protein; Region: OsmC; cl00767 662755005808 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 662755005809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 662755005810 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 662755005811 DNA binding residues [nucleotide binding] 662755005812 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 662755005813 hydrophobic ligand binding site; other site 662755005814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755005815 TIGR01777 family protein; Region: yfcH 662755005816 NAD(P) binding site [chemical binding]; other site 662755005817 active site 662755005818 ferrochelatase; Reviewed; Region: hemH; PRK00035 662755005819 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 662755005820 C-terminal domain interface [polypeptide binding]; other site 662755005821 active site 662755005822 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 662755005823 active site 662755005824 N-terminal domain interface [polypeptide binding]; other site 662755005825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 662755005826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755005827 putative substrate translocation pore; other site 662755005828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755005829 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 662755005830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755005831 NAD(P) binding site [chemical binding]; other site 662755005832 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 662755005833 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 662755005834 aspartate kinase; Reviewed; Region: PRK06635 662755005835 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 662755005836 putative nucleotide binding site [chemical binding]; other site 662755005837 putative catalytic residues [active] 662755005838 putative Mg ion binding site [ion binding]; other site 662755005839 putative aspartate binding site [chemical binding]; other site 662755005840 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 662755005841 putative allosteric regulatory site; other site 662755005842 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 662755005843 putative allosteric regulatory residue; other site 662755005844 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 662755005845 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 662755005846 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 662755005847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 662755005848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 662755005849 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 662755005850 active site 662755005851 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 662755005852 2-isopropylmalate synthase; Validated; Region: PRK03739 662755005853 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 662755005854 active site 662755005855 catalytic residues [active] 662755005856 metal binding site [ion binding]; metal-binding site 662755005857 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 662755005858 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 662755005859 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 662755005860 active site 662755005861 substrate binding site [chemical binding]; other site 662755005862 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 662755005863 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 662755005864 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 662755005865 catalytic triad [active] 662755005866 Predicted membrane protein [Function unknown]; Region: COG4270 662755005867 recombination protein RecR; Reviewed; Region: recR; PRK00076 662755005868 RecR protein; Region: RecR; pfam02132 662755005869 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 662755005870 putative active site [active] 662755005871 putative metal-binding site [ion binding]; other site 662755005872 tetramer interface [polypeptide binding]; other site 662755005873 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 662755005874 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 662755005875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 662755005876 Walker A motif; other site 662755005877 ATP binding site [chemical binding]; other site 662755005878 Walker B motif; other site 662755005879 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 662755005880 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 662755005881 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 662755005882 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 662755005883 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 662755005884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755005885 homodimer interface [polypeptide binding]; other site 662755005886 catalytic residue [active] 662755005887 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 662755005888 metal ion-dependent adhesion site (MIDAS); other site 662755005889 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 662755005890 proposed catalytic triad [active] 662755005891 conserved cys residue [active] 662755005892 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 662755005893 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 662755005894 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 662755005895 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 662755005896 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 662755005897 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 662755005898 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 662755005899 helicase Cas3; Provisional; Region: PRK09694 662755005900 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 662755005901 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755005902 enoyl-CoA hydratase; Provisional; Region: PRK07509 662755005903 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 662755005904 substrate binding site [chemical binding]; other site 662755005905 oxyanion hole (OAH) forming residues; other site 662755005906 trimer interface [polypeptide binding]; other site 662755005907 Quinolinate synthetase A protein; Region: NadA; cl00420 662755005908 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 662755005909 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 662755005910 dimerization interface [polypeptide binding]; other site 662755005911 active site 662755005912 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 662755005913 putative active site [active] 662755005914 putative metal binding site [ion binding]; other site 662755005915 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 662755005916 glutamyl-tRNA synthetase; Region: PLN02627 662755005917 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 662755005918 active site 662755005919 HIGH motif; other site 662755005920 nucleotide binding site [chemical binding]; other site 662755005921 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 662755005922 active site 662755005923 KMSKS motif; other site 662755005924 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 662755005925 Integrase core domain; Region: rve; cl01316 662755005926 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 662755005927 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 662755005928 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 662755005929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755005930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755005931 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 662755005932 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 662755005933 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 662755005934 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 662755005935 nudix motif; other site 662755005936 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 662755005937 Secretory lipase; Region: LIP; pfam03583 662755005938 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 662755005939 nucleoside/Zn binding site; other site 662755005940 dimer interface [polypeptide binding]; other site 662755005941 catalytic motif [active] 662755005942 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 662755005943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755005944 MULE transposase domain; Region: MULE; pfam10551 662755005945 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755005946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 662755005947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 662755005948 homodimer interface [polypeptide binding]; other site 662755005949 catalytic residue [active] 662755005950 Transposase; Region: DEDD_Tnp_IS110; pfam01548 662755005951 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 662755005952 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 662755005953 helix-hairpin-helix signature motif; other site 662755005954 active site 662755005955 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 662755005956 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 662755005957 NAD(P) binding site [chemical binding]; other site 662755005958 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 662755005959 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 662755005960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 662755005961 ABC-2 type transporter; Region: ABC2_membrane; cl11417 662755005962 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 662755005963 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 662755005964 Walker A/P-loop; other site 662755005965 ATP binding site [chemical binding]; other site 662755005966 Q-loop/lid; other site 662755005967 ABC transporter signature motif; other site 662755005968 Walker B; other site 662755005969 D-loop; other site 662755005970 H-loop/switch region; other site 662755005971 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 662755005972 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 662755005973 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 662755005974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 662755005975 active site 662755005976 GtrA-like protein; Region: GtrA; cl00971 662755005977 GtrA-like protein; Region: GtrA; cl00971 662755005978 Divergent AAA domain; Region: AAA_4; pfam04326 662755005979 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 662755005980 Arginase family; Region: Arginase; cl00306 662755005981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755005982 Bacterial transcriptional regulator; Region: IclR; pfam01614 662755005983 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 662755005984 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 662755005985 active site 662755005986 urocanate hydratase; Provisional; Region: PRK05414 662755005987 urocanate hydratase; Region: hutU; TIGR01228 662755005988 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 662755005989 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 662755005990 active sites [active] 662755005991 tetramer interface [polypeptide binding]; other site 662755005992 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 662755005993 FAD binding domain; Region: FAD_binding_4; pfam01565 662755005994 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 662755005995 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 662755005996 classical (c) SDRs; Region: SDR_c; cd05233 662755005997 NAD(P) binding site [chemical binding]; other site 662755005998 active site 662755005999 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 662755006000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755006001 putative substrate translocation pore; other site 662755006002 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 662755006003 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 662755006004 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 662755006005 putative NAD(P) binding site [chemical binding]; other site 662755006006 putative substrate binding site [chemical binding]; other site 662755006007 catalytic Zn binding site [ion binding]; other site 662755006008 structural Zn binding site [ion binding]; other site 662755006009 dimer interface [polypeptide binding]; other site 662755006010 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 662755006011 catalytic residues [active] 662755006012 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 662755006013 CoenzymeA binding site [chemical binding]; other site 662755006014 subunit interaction site [polypeptide binding]; other site 662755006015 PHB binding site; other site 662755006016 CrcB-like protein; Region: CRCB; cl09114 662755006017 CrcB-like protein; Region: CRCB; cl09114 662755006018 Transcriptional regulators [Transcription]; Region: MarR; COG1846 662755006019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755006020 replicative DNA helicase; Provisional; Region: PRK05636 662755006021 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 662755006022 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 662755006023 Walker A motif; other site 662755006024 ATP binding site [chemical binding]; other site 662755006025 Walker B motif; other site 662755006026 DNA binding loops [nucleotide binding] 662755006027 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 662755006028 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 662755006029 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 662755006030 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 662755006031 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 662755006032 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 662755006033 dimer interface [polypeptide binding]; other site 662755006034 ssDNA binding site [nucleotide binding]; other site 662755006035 tetramer (dimer of dimers) interface [polypeptide binding]; other site 662755006036 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 662755006037 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 662755006038 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 662755006039 Transglycosylase; Region: Transgly; cl07896 662755006040 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 662755006041 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 662755006042 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 662755006043 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 662755006044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 662755006045 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 662755006046 Ligand Binding Site [chemical binding]; other site 662755006047 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 662755006048 Ligand Binding Site [chemical binding]; other site 662755006049 DNA photolyase; Region: DNA_photolyase; pfam00875 662755006050 Cation efflux family; Region: Cation_efflux; cl00316 662755006051 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 662755006052 Transposase, Mutator family; Region: Transposase_mut; pfam00872 662755006053 MULE transposase domain; Region: MULE; pfam10551 662755006054 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 662755006055 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 662755006056 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 662755006057 HIGH motif; other site 662755006058 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 662755006059 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 662755006060 active site 662755006061 KMSKS motif; other site 662755006062 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 662755006063 tRNA binding surface [nucleotide binding]; other site 662755006064 Histidine kinase; Region: HisKA_3; pfam07730 662755006065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 662755006066 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 662755006067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 662755006068 active site 662755006069 phosphorylation site [posttranslational modification] 662755006070 intermolecular recognition site; other site 662755006071 dimerization interface [polypeptide binding]; other site 662755006072 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 662755006073 DNA binding residues [nucleotide binding] 662755006074 dimerization interface [polypeptide binding]; other site 662755006075 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 662755006076 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 662755006077 substrate binding site [chemical binding]; other site 662755006078 ATP binding site [chemical binding]; other site 662755006079 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 662755006080 active site 662755006081 tetramer interface [polypeptide binding]; other site 662755006082 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 662755006083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755006084 putative substrate translocation pore; other site 662755006085 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 662755006086 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 662755006087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755006088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755006089 Membrane transport protein; Region: Mem_trans; cl09117 662755006090 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 662755006091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 662755006092 putative substrate translocation pore; other site 662755006093 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 662755006094 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 662755006095 Walker A/P-loop; other site 662755006096 ATP binding site [chemical binding]; other site 662755006097 Q-loop/lid; other site 662755006098 ABC transporter signature motif; other site 662755006099 Walker B; other site 662755006100 D-loop; other site 662755006101 H-loop/switch region; other site 662755006102 ABC transporter; Region: ABC_tran_2; pfam12848 662755006103 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 662755006104 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 662755006105 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 662755006106 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 662755006107 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 662755006108 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 662755006109 Cysteine-rich domain; Region: CCG; pfam02754 662755006110 Cysteine-rich domain; Region: CCG; pfam02754 662755006111 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 662755006112 nudix motif; other site 662755006113 Sec24-related protein; Provisional; Region: PTZ00395 662755006114 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 662755006115 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 662755006116 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 662755006117 active site 662755006118 NTP binding site [chemical binding]; other site 662755006119 metal binding triad [ion binding]; metal-binding site 662755006120 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 662755006121 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 662755006122 Zn2+ binding site [ion binding]; other site 662755006123 Mg2+ binding site [ion binding]; other site 662755006124 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 662755006125 active site 662755006126 Ap6A binding site [chemical binding]; other site 662755006127 nudix motif; other site 662755006128 metal binding site [ion binding]; metal-binding site 662755006129 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 662755006130 MatE; Region: MatE; cl10513 662755006131 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 662755006132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 662755006133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 662755006134 DNA binding residues [nucleotide binding] 662755006135 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 662755006136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 662755006137 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 662755006138 catalytic residues [active] 662755006139 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 662755006140 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 662755006141 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 662755006142 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 662755006143 active site 662755006144 metal binding site [ion binding]; metal-binding site 662755006145 ParB-like partition proteins; Region: parB_part; TIGR00180 662755006146 ParB-like nuclease domain; Region: ParBc; cl02129 662755006147 KorB domain; Region: KorB; pfam08535 662755006148 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 662755006149 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 662755006150 P-loop; other site 662755006151 Magnesium ion binding site [ion binding]; other site 662755006152 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 662755006153 Magnesium ion binding site [ion binding]; other site 662755006154 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 662755006155 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 662755006156 Ribosomal protein L34; Region: Ribosomal_L34; cl00370