-- dump date 20120504_143018 -- class Genbank::misc_feature -- table misc_feature_note -- id note 266264000001 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264000002 DNA binding residues [nucleotide binding] 266264000003 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266264000004 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264000005 P-loop; other site 266264000006 Magnesium ion binding site [ion binding]; other site 266264000007 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264000008 Magnesium ion binding site [ion binding]; other site 266264000009 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 266264000010 ParB-like nuclease domain; Region: ParBc; cl02129 266264000011 Initiator Replication protein; Region: Rep_3; cl03080 266264000012 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 266264000013 PAS domain; Region: PAS_9; pfam13426 266264000014 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264000015 active site 266264000016 I-site; other site 266264000017 metal binding site [ion binding]; metal-binding site 266264000018 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264000019 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 266264000020 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266264000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000022 Family description; Region: UvrD_C_2; cl15862 266264000023 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266264000024 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 266264000025 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 266264000026 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 266264000027 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 266264000028 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 266264000029 putative active site [active] 266264000030 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266264000031 Active Sites [active] 266264000032 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 266264000033 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266264000034 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264000035 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 266264000036 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266264000037 HSP70 interaction site [polypeptide binding]; other site 266264000038 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266264000039 Zn binding sites [ion binding]; other site 266264000040 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266264000041 dimer interface [polypeptide binding]; other site 266264000042 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 266264000043 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264000044 trimer interface [polypeptide binding]; other site 266264000045 eyelet of channel; other site 266264000046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264000047 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 266264000048 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264000049 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 266264000050 active site 266264000051 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266264000052 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266264000053 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264000054 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264000055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264000056 DNA-binding site [nucleotide binding]; DNA binding site 266264000057 FCD domain; Region: FCD; cl11656 266264000058 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264000059 MerT mercuric transport protein; Region: MerT; cl03578 266264000060 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 266264000061 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 266264000062 DNA binding residues [nucleotide binding] 266264000063 dimer interface [polypeptide binding]; other site 266264000064 mercury binding site [ion binding]; other site 266264000065 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264000066 Cytochrome c; Region: Cytochrom_C; cl11414 266264000067 Cytochrome c [Energy production and conversion]; Region: COG3258 266264000068 Cytochrome c; Region: Cytochrom_C; cl11414 266264000069 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266264000070 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264000071 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 266264000072 Int/Topo IB signature motif; other site 266264000073 transcriptional regulator, AraC family (fragment) 266264000074 MgtC family; Region: MgtC; pfam02308 266264000075 Phospholipid methyltransferase; Region: PEMT; cl00763 266264000076 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264000077 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 266264000078 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264000079 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 266264000080 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264000081 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 266264000082 Cation efflux family; Region: Cation_efflux; cl00316 266264000083 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266264000084 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266264000085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000086 active site 266264000087 phosphorylation site [posttranslational modification] 266264000088 intermolecular recognition site; other site 266264000089 dimerization interface [polypeptide binding]; other site 266264000090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264000091 DNA binding site [nucleotide binding] 266264000092 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264000093 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264000094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264000095 dimer interface [polypeptide binding]; other site 266264000096 phosphorylation site [posttranslational modification] 266264000097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000098 ATP binding site [chemical binding]; other site 266264000099 Mg2+ binding site [ion binding]; other site 266264000100 G-X-G motif; other site 266264000101 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264000102 trimer interface [polypeptide binding]; other site 266264000103 eyelet of channel; other site 266264000104 putative transposase OrfB; Reviewed; Region: PHA02517 266264000105 HTH-like domain; Region: HTH_21; pfam13276 266264000106 Integrase core domain; Region: rve; cl01316 266264000107 Integrase core domain; Region: rve_3; cl15866 266264000108 Helix-turn-helix domains; Region: HTH; cl00088 266264000109 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 266264000110 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 266264000111 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264000112 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 266264000113 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264000114 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 266264000115 Double zinc ribbon; Region: DZR; pfam12773 266264000116 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266264000117 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266264000118 Ligand binding site; other site 266264000119 Putative Catalytic site; other site 266264000120 DXD motif; other site 266264000121 GtrA-like protein; Region: GtrA; cl00971 266264000122 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 266264000123 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266264000124 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 266264000125 Helix-turn-helix domains; Region: HTH; cl00088 266264000126 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264000127 Helix-turn-helix domains; Region: HTH; cl00088 266264000128 Integrase core domain; Region: rve; cl01316 266264000129 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266264000130 active site 266264000131 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 266264000132 lipoprotein signal peptidase; Provisional; Region: PRK14787 266264000133 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 266264000134 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264000135 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 266264000136 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264000137 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264000138 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266264000139 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266264000140 DNA binding residues [nucleotide binding] 266264000141 dimer interface [polypeptide binding]; other site 266264000142 putative metal binding site [ion binding]; other site 266264000143 Cytochrome c; Region: Cytochrom_C; cl11414 266264000144 Iron permease FTR1 family; Region: FTR1; cl00475 266264000145 AAA domain; Region: AAA_22; pfam13401 266264000146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000147 Walker A motif; other site 266264000148 ATP binding site [chemical binding]; other site 266264000149 Walker B motif; other site 266264000150 arginine finger; other site 266264000151 Integrase core domain; Region: rve; cl01316 266264000152 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264000153 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264000154 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264000155 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 266264000156 MerE protein; Region: MerE; cl04911 266264000157 transcriptional regulator MerD; Provisional; Region: PRK13749 266264000158 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 266264000159 DNA binding residues [nucleotide binding] 266264000160 putative dimer interface [polypeptide binding]; other site 266264000161 putative mercuric reductase; Provisional; Region: PRK13748 266264000162 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264000163 metal-binding site [ion binding] 266264000164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264000165 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264000166 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264000167 metal-binding site [ion binding] 266264000168 MerT mercuric transport protein; Region: MerT; cl03578 266264000169 putative transcriptional regulator MerR; Provisional; Region: PRK13752 266264000170 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 266264000171 DNA binding residues [nucleotide binding] 266264000172 dimer interface [polypeptide binding]; other site 266264000173 mercury binding site [ion binding]; other site 266264000174 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 266264000175 dimerization domain [polypeptide binding]; other site 266264000176 dimer interface [polypeptide binding]; other site 266264000177 catalytic residues [active] 266264000178 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 266264000179 TraU protein; Region: TraU; cl06067 266264000180 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 266264000181 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 266264000182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264000183 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 266264000184 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 266264000185 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 266264000186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264000187 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 266264000188 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264000189 nucleophilic elbow; other site 266264000190 catalytic triad; other site 266264000191 NMT1-like family; Region: NMT1_2; cl15260 266264000192 Outer membrane efflux protein; Region: OEP; pfam02321 266264000193 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 266264000194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264000195 H+ Antiporter protein; Region: 2A0121; TIGR00900 266264000196 putative substrate translocation pore; other site 266264000197 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 266264000198 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266264000199 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264000200 PAS domain; Region: PAS_9; pfam13426 266264000201 putative active site [active] 266264000202 heme pocket [chemical binding]; other site 266264000203 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264000204 metal binding site [ion binding]; metal-binding site 266264000205 active site 266264000206 I-site; other site 266264000207 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264000208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264000209 putative substrate translocation pore; other site 266264000210 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 266264000211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264000212 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264000213 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 266264000214 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264000215 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 266264000216 Outer membrane efflux protein; Region: OEP; pfam02321 266264000217 Protein of unknown function (DUF541); Region: SIMPL; cl01077 266264000218 hypothetical protein; Provisional; Region: PRK08317 266264000219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264000220 S-adenosylmethionine binding site [chemical binding]; other site 266264000221 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 266264000222 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 266264000223 GtrA-like protein; Region: GtrA; cl00971 266264000224 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266264000225 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266264000226 Ligand binding site; other site 266264000227 Putative Catalytic site; other site 266264000228 DXD motif; other site 266264000229 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264000230 trimer interface [polypeptide binding]; other site 266264000231 eyelet of channel; other site 266264000232 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 266264000233 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 266264000234 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264000235 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264000236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264000237 active site 266264000238 motif I; other site 266264000239 motif II; other site 266264000240 Protein of unknown function, DUF; Region: DUF411; cl01142 266264000241 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264000242 Cytochrome c; Region: Cytochrom_C; cl11414 266264000243 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264000244 Copper resistance protein D; Region: CopD; cl00563 266264000245 Bacterial Ig-like domain; Region: Big_5; cl01012 266264000246 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 266264000247 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 266264000248 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 266264000249 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264000250 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264000251 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264000252 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 266264000253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000254 active site 266264000255 phosphorylation site [posttranslational modification] 266264000256 intermolecular recognition site; other site 266264000257 dimerization interface [polypeptide binding]; other site 266264000258 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264000259 DNA binding site [nucleotide binding] 266264000260 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264000261 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264000262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264000263 dimer interface [polypeptide binding]; other site 266264000264 phosphorylation site [posttranslational modification] 266264000265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000266 ATP binding site [chemical binding]; other site 266264000267 Mg2+ binding site [ion binding]; other site 266264000268 G-X-G motif; other site 266264000269 Copper resistance protein K; Region: CopK; pfam11525 266264000270 Cytochrome c; Region: Cytochrom_C; cl11414 266264000271 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 266264000272 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266264000273 Peptidase M30; Region: Peptidase_M30; pfam10460 266264000274 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 266264000275 hypothetical protein; Reviewed; Region: PRK09588 266264000276 Phage integrase protein; Region: DUF3701; pfam12482 266264000277 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 266264000278 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 266264000279 Int/Topo IB signature motif; other site 266264000280 Protein of unknown function DUF91; Region: DUF91; cl00709 266264000281 putative transposase OrfB; Reviewed; Region: PHA02517 266264000282 HTH-like domain; Region: HTH_21; pfam13276 266264000283 Integrase core domain; Region: rve; cl01316 266264000284 Integrase core domain; Region: rve_3; cl15866 266264000285 Helix-turn-helix domains; Region: HTH; cl00088 266264000286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264000287 non-specific DNA binding site [nucleotide binding]; other site 266264000288 salt bridge; other site 266264000289 sequence-specific DNA binding site [nucleotide binding]; other site 266264000290 putative transposase OrfB; Reviewed; Region: PHA02517 266264000291 HTH-like domain; Region: HTH_21; pfam13276 266264000292 Integrase core domain; Region: rve; cl01316 266264000293 Integrase core domain; Region: rve_3; cl15866 266264000294 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 266264000295 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266264000296 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264000297 P-loop; other site 266264000298 Magnesium ion binding site [ion binding]; other site 266264000299 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264000300 Magnesium ion binding site [ion binding]; other site 266264000301 ParB-like partition proteins; Region: parB_part; TIGR00180 266264000302 ParB-like nuclease domain; Region: ParBc; cl02129 266264000303 RES domain; Region: RES; cl02411 266264000304 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266264000305 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 266264000306 Int/Topo IB signature motif; other site 266264000307 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 266264000308 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 266264000309 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 266264000310 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 266264000311 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266264000312 active site 266264000313 Integrase core domain; Region: rve; cl01316 266264000314 AAA domain; Region: AAA_22; pfam13401 266264000315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000316 Walker A motif; other site 266264000317 ATP binding site [chemical binding]; other site 266264000318 Walker B motif; other site 266264000319 arginine finger; other site 266264000320 Cupin domain; Region: Cupin_2; cl09118 266264000321 Chlorite dismutase; Region: Chlor_dismutase; cl01280 266264000322 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 266264000323 putative transcriptional regulator MerR; Provisional; Region: PRK13752 266264000324 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 266264000325 DNA binding residues [nucleotide binding] 266264000326 dimer interface [polypeptide binding]; other site 266264000327 mercury binding site [ion binding]; other site 266264000328 MerT mercuric transport protein; Region: MerT; cl03578 266264000329 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264000330 metal-binding site [ion binding] 266264000331 putative mercuric reductase; Provisional; Region: PRK13748 266264000332 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264000333 metal-binding site [ion binding] 266264000334 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264000335 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264000336 transcriptional regulator MerD; Provisional; Region: PRK13749 266264000337 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 266264000338 DNA binding residues [nucleotide binding] 266264000339 putative dimer interface [polypeptide binding]; other site 266264000340 MerE protein; Region: MerE; cl04911 266264000341 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264000342 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 266264000343 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264000344 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264000345 catalytic residues [active] 266264000346 catalytic nucleophile [active] 266264000347 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264000348 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264000349 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264000350 Synaptic Site I dimer interface [polypeptide binding]; other site 266264000351 DNA binding site [nucleotide binding] 266264000352 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264000353 DNA-binding interface [nucleotide binding]; DNA binding site 266264000354 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264000355 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264000356 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 266264000357 IHF dimer interface [polypeptide binding]; other site 266264000358 IHF - DNA interface [nucleotide binding]; other site 266264000359 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266264000360 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264000361 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 266264000362 Int/Topo IB signature motif; other site 266264000363 Uncharacterized conserved protein [Function unknown]; Region: COG3391 266264000364 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266264000365 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266264000366 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 266264000367 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 266264000368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264000369 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 266264000370 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 266264000371 active site residue [active] 266264000372 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 266264000373 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266264000374 Chromate transporter; Region: Chromate_transp; pfam02417 266264000375 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 266264000376 Chromate transporter; Region: Chromate_transp; pfam02417 266264000377 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 266264000378 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266264000379 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266264000380 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 266264000381 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266264000382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264000383 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264000384 DNA binding residues [nucleotide binding] 266264000385 Outer membrane efflux protein; Region: OEP; pfam02321 266264000386 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 266264000387 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264000388 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 266264000389 EamA-like transporter family; Region: EamA; cl01037 266264000390 EamA-like transporter family; Region: EamA; cl01037 266264000391 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264000392 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264000393 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266264000394 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 266264000395 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000396 Walker A/P-loop; other site 266264000397 ATP binding site [chemical binding]; other site 266264000398 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266264000399 active site 266264000400 metal binding site [ion binding]; metal-binding site 266264000401 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 266264000402 Domain of unknown function (DUF932); Region: DUF932; cl12129 266264000403 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 266264000404 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 266264000405 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 266264000406 ATP binding site [chemical binding]; other site 266264000407 substrate interface [chemical binding]; other site 266264000408 Domain of unknown function (DUF2016); Region: DUF2016; pfam09436 266264000409 PRTRC system protein A; Region: PRTRC_A; TIGR03735 266264000410 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 266264000411 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 266264000412 PRTRC system protein F; Region: PRTRC_F; TIGR03742 266264000413 Alpha-helical domain 2; Region: alpha-hel2; pfam14456 266264000414 Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020 266264000415 PRTRC system protein E; Region: PRTRC_E; TIGR03741 266264000416 ParB-like nuclease domain; Region: ParBc; cl02129 266264000417 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 266264000418 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 266264000419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264000420 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266264000421 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266264000422 Family description; Region: UvrD_C_2; cl15862 266264000423 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 266264000424 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 266264000425 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264000426 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266264000427 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264000428 active site 266264000429 catalytic residues [active] 266264000430 DNA binding site [nucleotide binding] 266264000431 Int/Topo IB signature motif; other site 266264000432 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264000433 active site 266264000434 Int/Topo IB signature motif; other site 266264000435 DNA binding site [nucleotide binding] 266264000436 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264000437 active site 266264000438 DNA binding site [nucleotide binding] 266264000439 Int/Topo IB signature motif; other site 266264000440 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000441 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266264000442 RHS Repeat; Region: RHS_repeat; cl11982 266264000443 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 266264000444 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 266264000445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000446 Walker A motif; other site 266264000447 ATP binding site [chemical binding]; other site 266264000448 Walker B motif; other site 266264000449 arginine finger; other site 266264000450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264000451 Integrase core domain; Region: rve; cl01316 266264000452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266264000453 RHS Repeat; Region: RHS_repeat; cl11982 266264000454 RHS Repeat; Region: RHS_repeat; cl11982 266264000455 RHS Repeat; Region: RHS_repeat; cl11982 266264000456 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264000457 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266264000458 RHS Repeat; Region: RHS_repeat; cl11982 266264000459 RHS Repeat; Region: RHS_repeat; cl11982 266264000460 RHS Repeat; Region: RHS_repeat; cl11982 266264000461 RHS Repeat; Region: RHS_repeat; cl11982 266264000462 RHS Repeat; Region: RHS_repeat; cl11982 266264000463 RHS Repeat; Region: RHS_repeat; cl11982 266264000464 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 266264000465 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 266264000466 active site 266264000467 substrate binding site [chemical binding]; other site 266264000468 Mg2+ binding site [ion binding]; other site 266264000469 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266264000470 IHF dimer interface [polypeptide binding]; other site 266264000471 IHF - DNA interface [nucleotide binding]; other site 266264000472 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 266264000473 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264000474 active site 266264000475 catalytic residues [active] 266264000476 Int/Topo IB signature motif; other site 266264000477 DNA binding site [nucleotide binding] 266264000478 StbA protein; Region: StbA; pfam06406 266264000479 PRTRC system protein D; Region: PRTRC_D; TIGR03739 266264000480 CHC2 zinc finger; Region: zf-CHC2; cl15369 266264000481 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266264000482 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266264000483 dimer interface [polypeptide binding]; other site 266264000484 ssDNA binding site [nucleotide binding]; other site 266264000485 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266264000486 type III secretion system protein SpaS; Validated; Region: PRK08156 266264000487 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264000488 Helix-turn-helix domains; Region: HTH; cl00088 266264000489 Integrase core domain; Region: rve; cl01316 266264000490 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266264000491 PilS N terminal; Region: PilS; pfam08805 266264000492 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266264000493 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264000494 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000495 Walker A motif; other site 266264000496 ATP binding site [chemical binding]; other site 266264000497 Walker B motif; other site 266264000498 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 266264000499 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264000500 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 266264000501 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266264000502 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264000503 catalytic residue [active] 266264000504 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266264000505 VirB7 interaction site; other site 266264000506 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266264000507 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 266264000508 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266264000509 VirB7 interaction site; other site 266264000510 VirB8 protein; Region: VirB8; cl01500 266264000511 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 266264000512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000513 Walker A motif; other site 266264000514 ATP binding site [chemical binding]; other site 266264000515 Walker B motif; other site 266264000516 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266264000517 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 266264000518 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266264000519 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 266264000520 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 266264000521 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266264000522 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 266264000523 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 266264000524 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000525 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 266264000526 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266264000527 Family description; Region: UvrD_C_2; cl15862 266264000528 DnaA N-terminal domain; Region: DnaA_N; pfam11638 266264000529 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 266264000530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000531 Walker A motif; other site 266264000532 ATP binding site [chemical binding]; other site 266264000533 Walker B motif; other site 266264000534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000535 arginine finger; other site 266264000536 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 266264000537 DnaA box-binding interface [nucleotide binding]; other site 266264000538 DNA polymerase III subunit beta; Validated; Region: PRK05643 266264000539 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 266264000540 putative DNA binding surface [nucleotide binding]; other site 266264000541 dimer interface [polypeptide binding]; other site 266264000542 beta-clamp/clamp loader binding surface; other site 266264000543 beta-clamp/translesion DNA polymerase binding surface; other site 266264000544 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 266264000545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000546 ATP binding site [chemical binding]; other site 266264000547 Mg2+ binding site [ion binding]; other site 266264000548 G-X-G motif; other site 266264000549 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266264000550 anchoring element; other site 266264000551 dimer interface [polypeptide binding]; other site 266264000552 ATP binding site [chemical binding]; other site 266264000553 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 266264000554 active site 266264000555 putative metal-binding site [ion binding]; other site 266264000556 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 266264000557 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266264000558 Restriction endonuclease; Region: Mrr_cat; cl00516 266264000559 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266264000560 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266264000561 active site 266264000562 EamA-like transporter family; Region: EamA; cl01037 266264000563 Cupin domain; Region: Cupin_2; cl09118 266264000564 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266264000565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264000566 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266264000567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264000568 dimer interface [polypeptide binding]; other site 266264000569 conserved gate region; other site 266264000570 putative PBP binding loops; other site 266264000571 ABC-ATPase subunit interface; other site 266264000572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264000573 dimer interface [polypeptide binding]; other site 266264000574 conserved gate region; other site 266264000575 putative PBP binding loops; other site 266264000576 ABC-ATPase subunit interface; other site 266264000577 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266264000578 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000579 Walker A/P-loop; other site 266264000580 ATP binding site [chemical binding]; other site 266264000581 Q-loop/lid; other site 266264000582 ABC transporter signature motif; other site 266264000583 Walker B; other site 266264000584 D-loop; other site 266264000585 H-loop/switch region; other site 266264000586 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266264000587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264000588 Phospholipid methyltransferase; Region: PEMT; cl00763 266264000589 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 266264000590 homodimer interface [polypeptide binding]; other site 266264000591 chemical substrate binding site [chemical binding]; other site 266264000592 oligomer interface [polypeptide binding]; other site 266264000593 metal binding site [ion binding]; metal-binding site 266264000594 Protein of unknown function DUF72; Region: DUF72; cl00777 266264000595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000596 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266264000597 ATP binding site [chemical binding]; other site 266264000598 putative Mg++ binding site [ion binding]; other site 266264000599 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 266264000600 FOG: CBS domain [General function prediction only]; Region: COG0517 266264000601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264000602 putative substrate translocation pore; other site 266264000603 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 266264000604 catalytic residues [active] 266264000605 dimer interface [polypeptide binding]; other site 266264000606 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264000607 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266264000608 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264000609 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266264000610 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266264000611 metal binding site [ion binding]; metal-binding site 266264000612 putative dimer interface [polypeptide binding]; other site 266264000613 Cupin domain; Region: Cupin_2; cl09118 266264000614 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264000615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264000616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264000617 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264000618 putative substrate translocation pore; other site 266264000619 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 266264000620 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 266264000621 metal binding site [ion binding]; metal-binding site 266264000622 dimer interface [polypeptide binding]; other site 266264000623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264000624 NMT1-like family; Region: NMT1_2; cl15260 266264000625 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264000626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000627 active site 266264000628 phosphorylation site [posttranslational modification] 266264000629 intermolecular recognition site; other site 266264000630 dimerization interface [polypeptide binding]; other site 266264000631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264000632 DNA binding site [nucleotide binding] 266264000633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000634 active site 266264000635 phosphorylation site [posttranslational modification] 266264000636 intermolecular recognition site; other site 266264000637 dimerization interface [polypeptide binding]; other site 266264000638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264000639 DNA binding site [nucleotide binding] 266264000640 outer membrane protein (porin) (fragment) 266264000641 Helix-turn-helix domains; Region: HTH; cl00088 266264000642 putative transposase OrfB; Reviewed; Region: PHA02517 266264000643 HTH-like domain; Region: HTH_21; pfam13276 266264000644 Integrase core domain; Region: rve; cl01316 266264000645 Integrase core domain; Region: rve_3; cl15866 266264000646 outer membrane protein (porin) (fragment) 266264000647 Septum formation topological specificity factor MinE; Region: MinE; cl00538 266264000648 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 266264000649 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 266264000650 Switch I; other site 266264000651 Switch II; other site 266264000652 septum formation inhibitor; Reviewed; Region: PRK01973 266264000653 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 266264000654 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266264000655 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 266264000656 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 266264000657 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 266264000658 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264000659 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264000660 K+-transporting ATPase, c chain; Region: KdpC; cl00944 266264000661 sensor protein KdpD; Provisional; Region: PRK10490 266264000662 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 266264000663 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 266264000664 Ligand Binding Site [chemical binding]; other site 266264000665 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 266264000666 GAF domain; Region: GAF; cl15785 266264000667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264000668 phosphorylation site [posttranslational modification] 266264000669 dimer interface [polypeptide binding]; other site 266264000670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000671 ATP binding site [chemical binding]; other site 266264000672 Mg2+ binding site [ion binding]; other site 266264000673 G-X-G motif; other site 266264000674 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 266264000675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000676 active site 266264000677 phosphorylation site [posttranslational modification] 266264000678 intermolecular recognition site; other site 266264000679 dimerization interface [polypeptide binding]; other site 266264000680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264000681 DNA binding site [nucleotide binding] 266264000682 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266264000683 Sel1 repeat; Region: Sel1; cl02723 266264000684 Sel1 repeat; Region: Sel1; cl02723 266264000685 Sel1 repeat; Region: Sel1; cl02723 266264000686 Uncharacterized conserved protein [Function unknown]; Region: COG2308 266264000687 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 266264000688 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 266264000689 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266264000690 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266264000691 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 266264000692 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 266264000693 GatB domain; Region: GatB_Yqey; cl11497 266264000694 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266264000695 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264000696 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266264000697 Amidase; Region: Amidase; cl11426 266264000698 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 266264000699 rod shape-determining protein MreB; Provisional; Region: PRK13927 266264000700 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 266264000701 ATP binding site [chemical binding]; other site 266264000702 Cell division protein FtsA; Region: FtsA; cl11496 266264000703 rod shape-determining protein MreC; Provisional; Region: PRK13922 266264000704 rod shape-determining protein MreC; Region: MreC; pfam04085 266264000705 rod shape-determining protein MreD; Region: MreD; cl01087 266264000706 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 266264000707 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266264000708 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264000709 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 266264000710 GAF domain; Region: GAF; cl15785 266264000711 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266264000712 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264000713 active site 266264000714 DNA binding site [nucleotide binding] 266264000715 Int/Topo IB signature motif; other site 266264000716 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264000717 Helix-turn-helix domains; Region: HTH; cl00088 266264000718 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264000719 dimerization interface [polypeptide binding]; other site 266264000720 substrate binding pocket [chemical binding]; other site 266264000721 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 266264000722 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 266264000723 lipoyl synthase; Provisional; Region: PRK05481 266264000724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264000725 FeS/SAM binding site; other site 266264000726 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 266264000727 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 266264000728 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 266264000729 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 266264000730 putative active site [active] 266264000731 Protein of unknown function (DUF969); Region: DUF969; cl01573 266264000732 Protein of unknown function (DUF979); Region: DUF979; cl01572 266264000733 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 266264000734 putative substrate binding pocket [chemical binding]; other site 266264000735 AC domain interface; other site 266264000736 catalytic triad [active] 266264000737 AB domain interface; other site 266264000738 interchain disulfide; other site 266264000739 VanZ like family; Region: VanZ; cl01971 266264000740 Protein of unknown function (DUF330); Region: DUF330; cl01135 266264000741 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 266264000742 mce related protein; Region: MCE; pfam02470 266264000743 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 266264000744 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 266264000745 Walker A/P-loop; other site 266264000746 ATP binding site [chemical binding]; other site 266264000747 Q-loop/lid; other site 266264000748 ABC transporter signature motif; other site 266264000749 Walker B; other site 266264000750 D-loop; other site 266264000751 H-loop/switch region; other site 266264000752 Permease; Region: Permease; cl00510 266264000753 biotin--protein ligase; Provisional; Region: PRK06955 266264000754 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 266264000755 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 266264000756 Type III pantothenate kinase; Region: Pan_kinase; cl09130 266264000757 Sporulation related domain; Region: SPOR; cl10051 266264000758 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264000759 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 266264000760 active site 266264000761 nucleotide binding site [chemical binding]; other site 266264000762 HIGH motif; other site 266264000763 KMSKS motif; other site 266264000764 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 266264000765 dinuclear metal binding motif [ion binding]; other site 266264000766 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264000767 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266264000768 active site 266264000769 nucleophile elbow; other site 266264000770 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 266264000771 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264000772 substrate binding site [chemical binding]; other site 266264000773 oxyanion hole (OAH) forming residues; other site 266264000774 trimer interface [polypeptide binding]; other site 266264000775 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266264000776 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264000777 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264000778 Helix-turn-helix domains; Region: HTH; cl00088 266264000779 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264000780 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 266264000781 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266264000782 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 266264000783 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 266264000784 active site residue [active] 266264000785 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 266264000786 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 266264000787 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 266264000788 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 266264000789 substrate binding pocket [chemical binding]; other site 266264000790 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 266264000791 B12 binding site [chemical binding]; other site 266264000792 cobalt ligand [ion binding]; other site 266264000793 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 266264000794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264000795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000796 active site 266264000797 phosphorylation site [posttranslational modification] 266264000798 intermolecular recognition site; other site 266264000799 dimerization interface [polypeptide binding]; other site 266264000800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264000801 DNA binding residues [nucleotide binding] 266264000802 dimerization interface [polypeptide binding]; other site 266264000803 Response regulator receiver domain; Region: Response_reg; pfam00072 266264000804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000805 active site 266264000806 phosphorylation site [posttranslational modification] 266264000807 intermolecular recognition site; other site 266264000808 dimerization interface [polypeptide binding]; other site 266264000809 CHASE3 domain; Region: CHASE3; cl05000 266264000810 Histidine kinase; Region: HisKA_3; pfam07730 266264000811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000812 ATP binding site [chemical binding]; other site 266264000813 Mg2+ binding site [ion binding]; other site 266264000814 G-X-G motif; other site 266264000815 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 266264000816 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 266264000817 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 266264000818 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 266264000819 active site 266264000820 HIGH motif; other site 266264000821 KMSK motif region; other site 266264000822 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266264000823 tRNA binding surface [nucleotide binding]; other site 266264000824 anticodon binding site; other site 266264000825 Sporulation related domain; Region: SPOR; cl10051 266264000826 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 266264000827 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266264000828 catalytic residues [active] 266264000829 hinge region; other site 266264000830 alpha helical domain; other site 266264000831 short chain dehydrogenase; Provisional; Region: PRK08251 266264000832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264000833 NAD(P) binding site [chemical binding]; other site 266264000834 active site 266264000835 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266264000836 intersubunit interface [polypeptide binding]; other site 266264000837 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264000838 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266264000839 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 266264000840 DNA binding residues [nucleotide binding] 266264000841 putative dimer interface [polypeptide binding]; other site 266264000842 isovaleryl-CoA dehydrogenase; Region: PLN02519 266264000843 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 266264000844 substrate binding site [chemical binding]; other site 266264000845 FAD binding site [chemical binding]; other site 266264000846 catalytic base [active] 266264000847 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 266264000848 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891 266264000849 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 266264000850 active site clefts [active] 266264000851 zinc binding site [ion binding]; other site 266264000852 dimer interface [polypeptide binding]; other site 266264000853 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 266264000854 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264000855 dimer interface [polypeptide binding]; other site 266264000856 active site 266264000857 oxidoreductase; Provisional; Region: PRK12742 266264000858 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 266264000859 NADP binding site [chemical binding]; other site 266264000860 homodimer interface [polypeptide binding]; other site 266264000861 active site 266264000862 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264000863 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264000864 active site 266264000865 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 266264000866 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 266264000867 putative catalytic residue [active] 266264000868 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266264000869 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264000870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264000871 motif II; other site 266264000872 hypothetical protein; Provisional; Region: PRK01842 266264000873 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266264000874 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264000875 enoyl-CoA hydratase; Provisional; Region: PRK05995 266264000876 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264000877 substrate binding site [chemical binding]; other site 266264000878 oxyanion hole (OAH) forming residues; other site 266264000879 trimer interface [polypeptide binding]; other site 266264000880 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 266264000881 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264000882 inhibitor-cofactor binding pocket; inhibition site 266264000883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264000884 catalytic residue [active] 266264000885 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 266264000886 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264000887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264000888 catalytic residue [active] 266264000889 AAA domain; Region: AAA_26; pfam13500 266264000890 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000891 biotin synthase; Region: bioB; TIGR00433 266264000892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264000893 FeS/SAM binding site; other site 266264000894 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 266264000895 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 266264000896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264000897 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 266264000898 putative deacylase active site [active] 266264000899 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 266264000900 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264000901 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266264000902 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264000903 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 266264000904 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264000905 N-terminal plug; other site 266264000906 ligand-binding site [chemical binding]; other site 266264000907 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266264000908 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000909 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 266264000910 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266264000911 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 266264000912 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 266264000913 P-loop, Walker A motif; other site 266264000914 Base recognition motif; other site 266264000915 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 266264000916 ferric uptake regulator; Provisional; Region: fur; PRK09462 266264000917 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266264000918 metal binding site 2 [ion binding]; metal-binding site 266264000919 putative DNA binding helix; other site 266264000920 metal binding site 1 [ion binding]; metal-binding site 266264000921 dimer interface [polypeptide binding]; other site 266264000922 structural Zn2+ binding site [ion binding]; other site 266264000923 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264000924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264000925 NMT1-like family; Region: NMT1_2; cl15260 266264000926 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 266264000927 active site 266264000928 HslU subunit interaction site [polypeptide binding]; other site 266264000929 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 266264000930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000931 Walker A motif; other site 266264000932 ATP binding site [chemical binding]; other site 266264000933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264000934 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 266264000935 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 266264000936 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 266264000937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000938 active site 266264000939 phosphorylation site [posttranslational modification] 266264000940 intermolecular recognition site; other site 266264000941 dimerization interface [polypeptide binding]; other site 266264000942 Helix-turn-helix domains; Region: HTH; cl00088 266264000943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264000944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000945 ATP binding site [chemical binding]; other site 266264000946 Mg2+ binding site [ion binding]; other site 266264000947 G-X-G motif; other site 266264000948 Protein of unknown function (DUF461); Region: DUF461; cl01071 266264000949 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264000950 Helix-turn-helix domains; Region: HTH; cl00088 266264000951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264000952 dimerization interface [polypeptide binding]; other site 266264000953 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 266264000954 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 266264000955 feedback inhibition sensing region; other site 266264000956 homohexameric interface [polypeptide binding]; other site 266264000957 nucleotide binding site [chemical binding]; other site 266264000958 N-acetyl-L-glutamate binding site [chemical binding]; other site 266264000959 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264000960 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 266264000961 division inhibitor protein; Provisional; Region: slmA; PRK09480 266264000962 Helix-turn-helix domains; Region: HTH; cl00088 266264000963 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264000964 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 266264000965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264000966 S-adenosylmethionine binding site [chemical binding]; other site 266264000967 putative replication protein; Provisional; Region: PRK12377 266264000968 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 266264000969 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264000970 muropeptide transporter; Validated; Region: ampG; PRK11010 266264000971 muropeptide transporter; Reviewed; Region: ampG; PRK11902 266264000972 Peptidase family M48; Region: Peptidase_M48; cl12018 266264000973 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 266264000974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264000975 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 266264000976 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 266264000977 putative active site [active] 266264000978 putative catalytic site [active] 266264000979 putative DNA binding site [nucleotide binding]; other site 266264000980 putative phosphate binding site [ion binding]; other site 266264000981 metal binding site A [ion binding]; metal-binding site 266264000982 putative AP binding site [nucleotide binding]; other site 266264000983 putative metal binding site B [ion binding]; other site 266264000984 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264000985 active site 266264000986 amidophosphoribosyltransferase; Provisional; Region: PRK05793 266264000987 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264000988 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266264000989 active site 266264000990 nucleophile elbow; other site 266264000991 Patatin phospholipase; Region: DUF3734; pfam12536 266264000992 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 266264000993 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 266264000994 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266264000995 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266264000996 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 266264000997 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266264000998 putative acyl-acceptor binding pocket; other site 266264000999 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266264001000 putative acyl-acceptor binding pocket; other site 266264001001 S-adenosylmethionine synthetase; Validated; Region: PRK05250 266264001002 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 266264001003 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 266264001004 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 266264001005 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 266264001006 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 266264001007 NAD(P) binding site [chemical binding]; other site 266264001008 catalytic residues [active] 266264001009 choline dehydrogenase; Validated; Region: PRK02106 266264001010 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264001011 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264001012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264001013 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264001014 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264001015 dimer interface [polypeptide binding]; other site 266264001016 putative CheW interface [polypeptide binding]; other site 266264001017 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 266264001018 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264001019 active site 266264001021 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 266264001022 ThiC-associated domain; Region: ThiC-associated; pfam13667 266264001023 ThiC family; Region: ThiC; cl08031 266264001024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264001025 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 266264001026 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 266264001027 thiS-thiF/thiG interaction site; other site 266264001028 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 266264001029 ThiS interaction site; other site 266264001030 putative active site [active] 266264001031 tetramer interface [polypeptide binding]; other site 266264001032 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266264001033 thiamine phosphate binding site [chemical binding]; other site 266264001034 active site 266264001035 pyrophosphate binding site [ion binding]; other site 266264001036 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264001037 CoenzymeA binding site [chemical binding]; other site 266264001038 subunit interaction site [polypeptide binding]; other site 266264001039 PHB binding site; other site 266264001040 PGDYG protein; Region: PGDYG; pfam14083 266264001041 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 266264001042 dimer interface [polypeptide binding]; other site 266264001043 substrate binding site [chemical binding]; other site 266264001044 ATP binding site [chemical binding]; other site 266264001045 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 266264001046 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 266264001047 oligomerization interface [polypeptide binding]; other site 266264001048 active site 266264001049 NAD+ binding site [chemical binding]; other site 266264001050 Membrane protein of unknown function; Region: DUF360; cl00850 266264001051 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 266264001052 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266264001053 FAD binding site [chemical binding]; other site 266264001054 TfoX N-terminal domain; Region: TfoX_N; cl01167 266264001055 Ubiquitin-like proteins; Region: UBQ; cl00155 266264001056 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 266264001057 Protein of unknown function DUF82; Region: DUF82; pfam01927 266264001058 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 266264001059 lytic murein transglycosylase; Provisional; Region: PRK11619 266264001060 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266264001061 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264001062 catalytic residue [active] 266264001063 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 266264001064 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 266264001065 putative NAD(P) binding site [chemical binding]; other site 266264001066 active site 266264001067 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 266264001068 putative C-terminal domain interface [polypeptide binding]; other site 266264001069 putative GSH binding site (G-site) [chemical binding]; other site 266264001070 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264001071 putative dimer interface [polypeptide binding]; other site 266264001072 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 266264001073 putative dimer interface [polypeptide binding]; other site 266264001074 putative N-terminal domain interface [polypeptide binding]; other site 266264001075 putative substrate binding pocket (H-site) [chemical binding]; other site 266264001076 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 266264001077 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266264001078 active site 266264001079 NTP binding site [chemical binding]; other site 266264001080 metal binding triad [ion binding]; metal-binding site 266264001081 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266264001082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266264001083 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 266264001084 Uncharacterized conserved protein [Function unknown]; Region: COG1565 266264001085 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 266264001086 pteridine reductase; Provisional; Region: PRK09135 266264001087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264001088 NAD(P) binding site [chemical binding]; other site 266264001089 active site 266264001090 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266264001091 active site 266264001092 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 266264001093 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 266264001094 Ligand Binding Site [chemical binding]; other site 266264001095 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 266264001096 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 266264001097 Substrate binding site; other site 266264001098 Mg++ binding site; other site 266264001099 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 266264001100 active site 266264001101 substrate binding site [chemical binding]; other site 266264001102 CoA binding site [chemical binding]; other site 266264001103 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266264001104 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266264001105 glutaminase active site [active] 266264001106 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266264001107 dimer interface [polypeptide binding]; other site 266264001108 active site 266264001109 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266264001110 dimer interface [polypeptide binding]; other site 266264001111 active site 266264001112 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 266264001113 Type II transport protein GspH; Region: GspH; pfam12019 266264001114 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 266264001115 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 266264001116 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 266264001117 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 266264001118 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 266264001119 PilX N-terminal; Region: PilX_N; pfam14341 266264001120 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 266264001121 legume lectins; Region: lectin_L-type; cl14058 266264001122 homotetramer interaction site [polypeptide binding]; other site 266264001123 carbohydrate binding site [chemical binding]; other site 266264001124 metal binding site [ion binding]; metal-binding site 266264001125 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 266264001126 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 266264001127 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 266264001128 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 266264001129 dimerization interface [polypeptide binding]; other site 266264001130 active site 266264001131 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 266264001132 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 266264001133 heme binding site [chemical binding]; other site 266264001134 ferroxidase pore; other site 266264001135 ferroxidase diiron center [ion binding]; other site 266264001136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264001137 Coenzyme A binding pocket [chemical binding]; other site 266264001138 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266264001139 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266264001140 NADP binding site [chemical binding]; other site 266264001141 dimer interface [polypeptide binding]; other site 266264001142 Cation efflux family; Region: Cation_efflux; cl00316 266264001143 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266264001144 Helix-turn-helix domains; Region: HTH; cl00088 266264001145 transcriptional activator TtdR; Provisional; Region: PRK09801 266264001146 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264001147 dimerization interface [polypeptide binding]; other site 266264001148 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266264001149 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266264001150 substrate binding site [chemical binding]; other site 266264001151 ligand binding site [chemical binding]; other site 266264001152 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266264001153 substrate binding site [chemical binding]; other site 266264001154 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264001155 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 266264001156 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264001157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264001158 DNA-binding site [nucleotide binding]; DNA binding site 266264001159 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264001160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001161 homodimer interface [polypeptide binding]; other site 266264001162 catalytic residue [active] 266264001163 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 266264001164 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264001165 inhibitor-cofactor binding pocket; inhibition site 266264001166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001167 catalytic residue [active] 266264001168 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266264001169 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264001170 tetrameric interface [polypeptide binding]; other site 266264001171 NAD binding site [chemical binding]; other site 266264001172 catalytic residues [active] 266264001173 amino acid transporter; Region: 2A0306; TIGR00909 266264001174 Spore germination protein; Region: Spore_permease; cl15802 266264001175 Spore germination protein; Region: Spore_permease; cl15802 266264001176 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264001177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264001178 DNA-binding site [nucleotide binding]; DNA binding site 266264001179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264001180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001181 homodimer interface [polypeptide binding]; other site 266264001182 catalytic residue [active] 266264001183 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 266264001184 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 266264001185 B12 binding site [chemical binding]; other site 266264001186 cobalt ligand [ion binding]; other site 266264001187 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 266264001188 Walker A; other site 266264001189 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 266264001190 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 266264001191 putative active site [active] 266264001192 putative substrate binding site [chemical binding]; other site 266264001193 putative coenzyme B12 binding site [chemical binding]; other site 266264001194 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 266264001195 HIT family signature motif; other site 266264001196 catalytic residue [active] 266264001197 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 266264001198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264001199 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264001200 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264001201 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264001202 ligand binding site [chemical binding]; other site 266264001203 flexible hinge region; other site 266264001204 Helix-turn-helix domains; Region: HTH; cl00088 266264001205 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 266264001206 AMP-binding enzyme; Region: AMP-binding; cl15778 266264001207 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264001208 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264001209 Walker A/P-loop; other site 266264001210 ATP binding site [chemical binding]; other site 266264001211 Q-loop/lid; other site 266264001212 ABC transporter signature motif; other site 266264001213 Walker B; other site 266264001214 D-loop; other site 266264001215 H-loop/switch region; other site 266264001216 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264001217 TM-ABC transporter signature motif; other site 266264001218 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264001219 TM-ABC transporter signature motif; other site 266264001220 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 266264001221 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264001222 putative ligand binding site [chemical binding]; other site 266264001223 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264001224 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264001225 Walker A/P-loop; other site 266264001226 ATP binding site [chemical binding]; other site 266264001227 Q-loop/lid; other site 266264001228 ABC transporter signature motif; other site 266264001229 Walker B; other site 266264001230 D-loop; other site 266264001231 H-loop/switch region; other site 266264001232 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 266264001233 AMP-binding enzyme; Region: AMP-binding; cl15778 266264001234 Protein of unknown function (DUF454); Region: DUF454; cl01063 266264001235 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264001236 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264001237 FMN binding site [chemical binding]; other site 266264001238 substrate binding site [chemical binding]; other site 266264001239 putative catalytic residue [active] 266264001240 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 266264001241 PUA domain; Region: PUA; cl00607 266264001242 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 266264001243 putative RNA binding site [nucleotide binding]; other site 266264001244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001245 S-adenosylmethionine binding site [chemical binding]; other site 266264001246 Protein of unknown function (DUF493); Region: DUF493; cl01102 266264001247 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266264001248 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264001249 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 266264001250 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 266264001251 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264001252 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 266264001253 dimer interface [polypeptide binding]; other site 266264001254 [2Fe-2S] cluster binding site [ion binding]; other site 266264001255 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 266264001256 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266264001257 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266264001258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264001259 dimer interface [polypeptide binding]; other site 266264001260 phosphorylation site [posttranslational modification] 266264001261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264001262 ATP binding site [chemical binding]; other site 266264001263 Mg2+ binding site [ion binding]; other site 266264001264 G-X-G motif; other site 266264001265 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264001266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264001267 active site 266264001268 phosphorylation site [posttranslational modification] 266264001269 intermolecular recognition site; other site 266264001270 dimerization interface [polypeptide binding]; other site 266264001271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264001272 Walker A motif; other site 266264001273 ATP binding site [chemical binding]; other site 266264001274 Walker B motif; other site 266264001275 arginine finger; other site 266264001276 Helix-turn-helix domains; Region: HTH; cl00088 266264001277 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266264001278 active sites [active] 266264001279 tetramer interface [polypeptide binding]; other site 266264001280 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266264001281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264001282 Family description; Region: UvrD_C_2; cl15862 266264001283 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266264001284 catalytic residues [active] 266264001285 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 266264001286 catalytic residues [active] 266264001287 LysE type translocator; Region: LysE; cl00565 266264001288 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 266264001289 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 266264001290 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264001291 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 266264001292 Membrane fusogenic activity; Region: BMFP; cl01115 266264001293 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 266264001294 Nitrogen regulatory protein P-II; Region: P-II; cl00412 266264001295 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266264001296 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 266264001297 Glutamate-cysteine ligase; Region: GshA; pfam08886 266264001298 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 266264001299 glutathione synthetase; Provisional; Region: PRK05246 266264001300 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 266264001301 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264001302 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 266264001303 active pocket/dimerization site; other site 266264001304 active site 266264001305 phosphorylation site [posttranslational modification] 266264001306 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266264001307 dimerization domain swap beta strand [polypeptide binding]; other site 266264001308 regulatory protein interface [polypeptide binding]; other site 266264001309 active site 266264001310 regulatory phosphorylation site [posttranslational modification]; other site 266264001311 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 266264001312 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266264001313 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 266264001314 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266264001315 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 266264001316 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 266264001317 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 266264001318 heme binding site [chemical binding]; other site 266264001319 ferroxidase pore; other site 266264001320 ferroxidase diiron center [ion binding]; other site 266264001321 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 266264001322 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 266264001323 ATP binding site [chemical binding]; other site 266264001324 substrate interface [chemical binding]; other site 266264001325 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 266264001326 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 266264001327 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 266264001328 protein binding site [polypeptide binding]; other site 266264001329 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 266264001330 Catalytic dyad [active] 266264001331 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264001332 catalytic core [active] 266264001333 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264001334 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266264001335 active site residue [active] 266264001336 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 266264001337 GSH binding site [chemical binding]; other site 266264001338 catalytic residues [active] 266264001339 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 266264001340 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 266264001341 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 266264001342 putative active site [active] 266264001343 putative NTP binding site [chemical binding]; other site 266264001344 putative nucleic acid binding site [nucleotide binding]; other site 266264001345 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 266264001346 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266264001347 active site 266264001348 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 266264001349 SecA binding site; other site 266264001350 Preprotein binding site; other site 266264001351 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 266264001352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264001353 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 266264001354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264001355 NMT1-like family; Region: NMT1_2; cl15260 266264001356 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 266264001357 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 266264001358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264001359 active site 266264001360 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 266264001361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001362 S-adenosylmethionine binding site [chemical binding]; other site 266264001363 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 266264001364 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 266264001365 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 266264001366 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264001367 Cytochrome c; Region: Cytochrom_C; cl11414 266264001368 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266264001369 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 266264001370 Subunit I/III interface [polypeptide binding]; other site 266264001371 D-pathway; other site 266264001372 Subunit I/VIIc interface [polypeptide binding]; other site 266264001373 Subunit I/IV interface [polypeptide binding]; other site 266264001374 Subunit I/II interface [polypeptide binding]; other site 266264001375 Low-spin heme (heme a) binding site [chemical binding]; other site 266264001376 Subunit I/VIIa interface [polypeptide binding]; other site 266264001377 Subunit I/VIa interface [polypeptide binding]; other site 266264001378 Dimer interface; other site 266264001379 Putative water exit pathway; other site 266264001380 Binuclear center (heme a3/CuB) [ion binding]; other site 266264001381 K-pathway; other site 266264001382 Subunit I/Vb interface [polypeptide binding]; other site 266264001383 Putative proton exit pathway; other site 266264001384 Subunit I/VIb interface; other site 266264001385 Subunit I/VIc interface [polypeptide binding]; other site 266264001386 Electron transfer pathway; other site 266264001387 Subunit I/VIIIb interface [polypeptide binding]; other site 266264001388 Subunit I/VIIb interface [polypeptide binding]; other site 266264001389 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 266264001390 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 266264001391 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 266264001392 Subunit III/VIIa interface [polypeptide binding]; other site 266264001393 Phospholipid binding site [chemical binding]; other site 266264001394 Subunit I/III interface [polypeptide binding]; other site 266264001395 Subunit III/VIb interface [polypeptide binding]; other site 266264001396 Subunit III/VIa interface; other site 266264001397 Subunit III/Vb interface [polypeptide binding]; other site 266264001398 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 266264001399 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 266264001400 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 266264001401 UbiA prenyltransferase family; Region: UbiA; cl00337 266264001402 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266264001403 Cu(I) binding site [ion binding]; other site 266264001404 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 266264001405 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266264001406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264001407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264001408 DNA binding residues [nucleotide binding] 266264001409 Pirin-related protein [General function prediction only]; Region: COG1741 266264001410 Cupin domain; Region: Cupin_2; cl09118 266264001411 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266264001412 glycosyl transferase family protein; Provisional; Region: PRK08136 266264001413 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266264001414 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266264001415 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 266264001416 Walker A/P-loop; other site 266264001417 ATP binding site [chemical binding]; other site 266264001418 Q-loop/lid; other site 266264001419 ABC transporter signature motif; other site 266264001420 Walker B; other site 266264001421 D-loop; other site 266264001422 H-loop/switch region; other site 266264001423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264001424 dimer interface [polypeptide binding]; other site 266264001425 conserved gate region; other site 266264001426 putative PBP binding loops; other site 266264001427 ABC-ATPase subunit interface; other site 266264001428 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266264001429 NMT1-like family; Region: NMT1_2; cl15260 266264001430 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 266264001431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 266264001432 active site 266264001433 phosphorylation site [posttranslational modification] 266264001434 intermolecular recognition site; other site 266264001435 dimerization interface [polypeptide binding]; other site 266264001436 ANTAR domain; Region: ANTAR; cl04297 266264001437 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264001438 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 266264001439 maleylacetoacetate isomerase; Region: maiA; TIGR01262 266264001440 C-terminal domain interface [polypeptide binding]; other site 266264001441 GSH binding site (G-site) [chemical binding]; other site 266264001442 putative dimer interface [polypeptide binding]; other site 266264001443 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 266264001444 dimer interface [polypeptide binding]; other site 266264001445 N-terminal domain interface [polypeptide binding]; other site 266264001446 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 266264001447 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 266264001448 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266264001449 P loop; other site 266264001450 GTP binding site [chemical binding]; other site 266264001451 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266264001452 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266264001453 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266264001454 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266264001455 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266264001456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001457 S-adenosylmethionine binding site [chemical binding]; other site 266264001458 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 266264001459 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 266264001460 active site 266264001461 (T/H)XGH motif; other site 266264001462 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 266264001463 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 266264001464 putative active site [active] 266264001465 catalytic residue [active] 266264001466 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 266264001467 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 266264001468 5S rRNA interface [nucleotide binding]; other site 266264001469 CTC domain interface [polypeptide binding]; other site 266264001470 L16 interface [polypeptide binding]; other site 266264001471 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 266264001472 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 266264001473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264001474 active site 266264001475 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 266264001476 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 266264001477 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 266264001478 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 266264001479 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 266264001480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264001481 binding surface 266264001482 TPR motif; other site 266264001483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264001484 binding surface 266264001485 TPR motif; other site 266264001486 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266264001487 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 266264001488 DNA binding site [nucleotide binding] 266264001489 catalytic residue [active] 266264001490 H2TH interface [polypeptide binding]; other site 266264001491 putative catalytic residues [active] 266264001492 turnover-facilitating residue; other site 266264001493 intercalation triad [nucleotide binding]; other site 266264001494 8OG recognition residue [nucleotide binding]; other site 266264001495 putative reading head residues; other site 266264001496 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266264001497 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266264001498 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264001499 Dynamin family; Region: Dynamin_N; pfam00350 266264001500 G1 box; other site 266264001501 GTP/Mg2+ binding site [chemical binding]; other site 266264001502 G2 box; other site 266264001503 Switch I region; other site 266264001504 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 266264001505 G3 box; other site 266264001506 Switch II region; other site 266264001507 GTP/Mg2+ binding site [chemical binding]; other site 266264001508 G4 box; other site 266264001509 G5 box; other site 266264001510 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 266264001511 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266264001512 minor groove reading motif; other site 266264001513 helix-hairpin-helix signature motif; other site 266264001514 substrate binding pocket [chemical binding]; other site 266264001515 active site 266264001516 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 266264001517 DNA binding and oxoG recognition site [nucleotide binding] 266264001518 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 266264001519 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 266264001520 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 266264001521 psiF repeat; Region: PsiF_repeat; pfam07769 266264001522 psiF repeat; Region: PsiF_repeat; pfam07769 266264001523 HPr kinase/phosphorylase; Provisional; Region: PRK05428 266264001524 DRTGG domain; Region: DRTGG; cl12147 266264001525 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 266264001526 Hpr binding site; other site 266264001527 active site 266264001528 homohexamer subunit interaction site [polypeptide binding]; other site 266264001529 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 266264001530 active site 266264001531 phosphorylation site [posttranslational modification] 266264001532 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 266264001533 30S subunit binding site; other site 266264001534 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 266264001535 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 266264001536 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 266264001537 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 266264001538 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 266264001539 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 266264001540 Walker A/P-loop; other site 266264001541 ATP binding site [chemical binding]; other site 266264001542 Q-loop/lid; other site 266264001543 ABC transporter signature motif; other site 266264001544 Walker B; other site 266264001545 D-loop; other site 266264001546 H-loop/switch region; other site 266264001547 OstA-like protein; Region: OstA; cl00844 266264001548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 266264001549 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 266264001550 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 266264001551 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 266264001552 putative active site [active] 266264001553 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 266264001554 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266264001555 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266264001556 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 266264001557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264001558 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266264001559 Ribbon-helix-helix domain; Region: RHH_4; cl01775 266264001560 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266264001561 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 266264001562 conserved cys residue [active] 266264001563 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264001564 active site 266264001565 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 266264001566 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266264001567 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266264001568 PhoU domain; Region: PhoU; pfam01895 266264001569 PhoU domain; Region: PhoU; pfam01895 266264001570 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 266264001571 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 266264001572 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 266264001573 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 266264001574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264001575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264001576 putative substrate translocation pore; other site 266264001577 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266264001578 dimer interface [polypeptide binding]; other site 266264001579 ssDNA binding site [nucleotide binding]; other site 266264001580 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266264001581 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264001582 DNA binding site [nucleotide binding] 266264001583 Int/Topo IB signature motif; other site 266264001584 active site 266264001585 catalytic residues [active] 266264001586 tyrosine-based site-specific recombinase (integrase) (partial) 266264001587 AAA domain; Region: AAA_22; pfam13401 266264001588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264001589 Walker A motif; other site 266264001590 ATP binding site [chemical binding]; other site 266264001591 Walker B motif; other site 266264001592 arginine finger; other site 266264001593 Integrase core domain; Region: rve; cl01316 266264001594 tyrosine-based site specific recombinase (partial) 266264001595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 266264001596 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264001597 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266264001598 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264001599 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 266264001600 ArsC family; Region: ArsC; pfam03960 266264001601 catalytic residues [active] 266264001602 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 266264001603 Membrane transport protein; Region: Mem_trans; cl09117 266264001604 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266264001605 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266264001606 active site 266264001607 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 266264001608 putative metal binding site [ion binding]; other site 266264001609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264001610 putative DNA binding site [nucleotide binding]; other site 266264001611 putative Zn2+ binding site [ion binding]; other site 266264001612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001613 S-adenosylmethionine binding site [chemical binding]; other site 266264001614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264001615 substrate binding pocket [chemical binding]; other site 266264001616 membrane-bound complex binding site; other site 266264001617 hinge residues; other site 266264001618 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266264001619 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264001620 catalytic residue [active] 266264001621 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264001622 Helix-turn-helix domains; Region: HTH; cl00088 266264001623 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264001624 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266264001625 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264001626 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264001627 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 266264001628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264001629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264001630 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 266264001631 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266264001632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264001633 putative substrate translocation pore; other site 266264001634 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 266264001635 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264001636 substrate binding pocket [chemical binding]; other site 266264001637 membrane-bound complex binding site; other site 266264001638 hinge residues; other site 266264001639 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266264001640 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266264001641 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266264001642 putative active site [active] 266264001643 hypothetical protein; Provisional; Region: PRK07483 266264001644 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264001645 inhibitor-cofactor binding pocket; inhibition site 266264001646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001647 catalytic residue [active] 266264001648 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266264001649 aspartate aminotransferase; Provisional; Region: PRK06108 266264001650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264001651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001652 homodimer interface [polypeptide binding]; other site 266264001653 catalytic residue [active] 266264001654 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264001655 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 266264001656 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266264001657 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266264001658 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 266264001659 Walker A/P-loop; other site 266264001660 ATP binding site [chemical binding]; other site 266264001661 Q-loop/lid; other site 266264001662 ABC transporter signature motif; other site 266264001663 Walker B; other site 266264001664 D-loop; other site 266264001665 H-loop/switch region; other site 266264001666 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264001667 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264001668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264001669 Helix-turn-helix domains; Region: HTH; cl00088 266264001670 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 266264001671 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 266264001672 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 266264001673 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266264001674 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266264001675 threonine dehydratase; Reviewed; Region: PRK09224 266264001676 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266264001677 tetramer interface [polypeptide binding]; other site 266264001678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001679 catalytic residue [active] 266264001680 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 266264001681 putative Ile/Val binding site [chemical binding]; other site 266264001682 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 266264001683 putative Ile/Val binding site [chemical binding]; other site 266264001684 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264001685 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 266264001686 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 266264001687 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266264001688 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 266264001689 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266264001690 active site 266264001691 homotetramer interface [polypeptide binding]; other site 266264001692 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266264001693 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 266264001694 Ligand binding site; other site 266264001695 metal-binding site 266264001696 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 266264001697 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266264001698 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266264001699 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 266264001700 putative hydrophobic ligand binding site [chemical binding]; other site 266264001701 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 266264001702 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266264001703 metal ion-dependent adhesion site (MIDAS); other site 266264001704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264001705 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264001706 Walker A motif; other site 266264001707 ATP binding site [chemical binding]; other site 266264001708 Walker B motif; other site 266264001709 arginine finger; other site 266264001710 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266264001711 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 266264001712 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266264001713 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266264001714 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264001715 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266264001716 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266264001717 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266264001718 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 266264001719 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264001720 FAD binding domain; Region: FAD_binding_4; pfam01565 266264001721 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 266264001722 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 266264001723 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266264001724 Cysteine-rich domain; Region: CCG; pfam02754 266264001725 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 266264001726 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 266264001727 nucleotide binding site/active site [active] 266264001728 HIT family signature motif; other site 266264001729 catalytic residue [active] 266264001730 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 266264001731 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266264001732 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 266264001733 Protein of unknown function (DUF971); Region: DUF971; cl01414 266264001734 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266264001735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001736 S-adenosylmethionine binding site [chemical binding]; other site 266264001737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264001738 Tim44-like domain; Region: Tim44; cl09208 266264001739 SCP-2 sterol transfer family; Region: SCP2; cl01225 266264001740 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 266264001741 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264001742 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 266264001743 Na binding site [ion binding]; other site 266264001744 putative glycosylation site [posttranslational modification]; other site 266264001745 putative glycosylation site [posttranslational modification]; other site 266264001746 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 266264001747 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 266264001748 Protein of unknown function (DUF502); Region: DUF502; cl01107 266264001749 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 266264001750 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 266264001751 dimer interface [polypeptide binding]; other site 266264001752 anticodon binding site; other site 266264001753 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 266264001754 homodimer interface [polypeptide binding]; other site 266264001755 motif 1; other site 266264001756 active site 266264001757 motif 2; other site 266264001758 GAD domain; Region: GAD; pfam02938 266264001759 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 266264001760 motif 3; other site 266264001761 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 266264001762 nudix motif; other site 266264001763 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266264001764 putative catalytic site [active] 266264001765 putative metal binding site [ion binding]; other site 266264001766 putative phosphate binding site [ion binding]; other site 266264001767 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 266264001768 Walker A motif; other site 266264001769 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 266264001770 putative active site [active] 266264001771 catalytic site [active] 266264001772 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 266264001773 PLD-like domain; Region: PLDc_2; pfam13091 266264001774 putative active site [active] 266264001775 catalytic site [active] 266264001776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264001777 Helix-turn-helix domains; Region: HTH; cl00088 266264001778 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266264001779 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266264001780 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 266264001781 FAD binding site [chemical binding]; other site 266264001782 substrate binding site [chemical binding]; other site 266264001783 catalytic residues [active] 266264001784 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266264001785 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266264001786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264001787 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264001788 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264001789 substrate binding site [chemical binding]; other site 266264001790 oxyanion hole (OAH) forming residues; other site 266264001791 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 266264001792 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264001793 dimer interface [polypeptide binding]; other site 266264001794 active site 266264001795 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 266264001796 enoyl-CoA hydratase; Provisional; Region: PRK06688 266264001797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264001798 substrate binding site [chemical binding]; other site 266264001799 oxyanion hole (OAH) forming residues; other site 266264001800 trimer interface [polypeptide binding]; other site 266264001801 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 266264001802 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266264001803 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 266264001804 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 266264001805 Walker A/P-loop; other site 266264001806 ATP binding site [chemical binding]; other site 266264001807 Q-loop/lid; other site 266264001808 ABC transporter signature motif; other site 266264001809 Walker B; other site 266264001810 D-loop; other site 266264001811 H-loop/switch region; other site 266264001812 NMT1/THI5 like; Region: NMT1; pfam09084 266264001813 NMT1-like family; Region: NMT1_2; cl15260 266264001814 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264001815 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266264001816 Walker A/P-loop; other site 266264001817 ATP binding site [chemical binding]; other site 266264001818 Q-loop/lid; other site 266264001819 ABC transporter signature motif; other site 266264001820 Walker B; other site 266264001821 D-loop; other site 266264001822 H-loop/switch region; other site 266264001823 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264001824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264001825 dimer interface [polypeptide binding]; other site 266264001826 conserved gate region; other site 266264001827 putative PBP binding loops; other site 266264001828 ABC-ATPase subunit interface; other site 266264001829 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264001830 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264001831 putative DNA binding site [nucleotide binding]; other site 266264001832 putative Zn2+ binding site [ion binding]; other site 266264001833 AsnC family; Region: AsnC_trans_reg; pfam01037 266264001834 Cysteine dioxygenase type I; Region: CDO_I; cl15835 266264001835 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264001836 Helix-turn-helix domains; Region: HTH; cl00088 266264001837 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264001838 dimerization interface [polypeptide binding]; other site 266264001839 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 266264001840 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 266264001841 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 266264001842 NAD(P) binding site [chemical binding]; other site 266264001843 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 266264001844 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264001845 substrate binding pocket [chemical binding]; other site 266264001846 membrane-bound complex binding site; other site 266264001847 hinge residues; other site 266264001848 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266264001849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264001850 dimer interface [polypeptide binding]; other site 266264001851 conserved gate region; other site 266264001852 putative PBP binding loops; other site 266264001853 ABC-ATPase subunit interface; other site 266264001854 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266264001855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264001856 dimer interface [polypeptide binding]; other site 266264001857 conserved gate region; other site 266264001858 putative PBP binding loops; other site 266264001859 ABC-ATPase subunit interface; other site 266264001860 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266264001861 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 266264001862 Walker A/P-loop; other site 266264001863 ATP binding site [chemical binding]; other site 266264001864 Q-loop/lid; other site 266264001865 ABC transporter signature motif; other site 266264001866 Walker B; other site 266264001867 D-loop; other site 266264001868 H-loop/switch region; other site 266264001869 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 266264001870 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 266264001871 putative active site [active] 266264001872 putative dimer interface [polypeptide binding]; other site 266264001873 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 266264001874 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 266264001875 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 266264001876 MOFRL family; Region: MOFRL; pfam05161 266264001877 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 266264001878 active site 266264001879 substrate binding pocket [chemical binding]; other site 266264001880 dimer interface [polypeptide binding]; other site 266264001881 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 266264001882 OsmC-like protein; Region: OsmC; cl00767 266264001883 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 266264001884 23S rRNA interface [nucleotide binding]; other site 266264001885 L3 interface [polypeptide binding]; other site 266264001886 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 266264001887 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 266264001888 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266264001889 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 266264001890 Peptidase family M23; Region: Peptidase_M23; pfam01551 266264001891 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 266264001892 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 266264001893 active site 266264001894 HIGH motif; other site 266264001895 dimer interface [polypeptide binding]; other site 266264001896 KMSKS motif; other site 266264001897 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264001898 RNA binding surface [nucleotide binding]; other site 266264001899 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 266264001900 putative active site [active] 266264001901 dimerization interface [polypeptide binding]; other site 266264001902 putative tRNAtyr binding site [nucleotide binding]; other site 266264001903 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 266264001904 substrate binding site [chemical binding]; other site 266264001905 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264001906 catalytic core [active] 266264001907 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 266264001908 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 266264001909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264001910 Walker A motif; other site 266264001911 ATP binding site [chemical binding]; other site 266264001912 Walker B motif; other site 266264001913 arginine finger; other site 266264001914 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 266264001915 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 266264001916 RuvA N terminal domain; Region: RuvA_N; pfam01330 266264001917 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 266264001918 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266264001919 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 266264001920 putative active site [active] 266264001921 catalytic site [active] 266264001922 putative metal binding site [ion binding]; other site 266264001923 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 266264001924 active site 266264001925 putative DNA-binding cleft [nucleotide binding]; other site 266264001926 dimer interface [polypeptide binding]; other site 266264001927 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 266264001928 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 266264001929 purine monophosphate binding site [chemical binding]; other site 266264001930 dimer interface [polypeptide binding]; other site 266264001931 putative catalytic residues [active] 266264001932 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 266264001933 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 266264001934 Helix-turn-helix domains; Region: HTH; cl00088 266264001935 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 266264001936 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266264001937 FMN binding site [chemical binding]; other site 266264001938 active site 266264001939 catalytic residues [active] 266264001940 substrate binding site [chemical binding]; other site 266264001941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264001942 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 266264001943 proline aminopeptidase P II; Provisional; Region: PRK10879 266264001944 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 266264001945 active site 266264001946 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 266264001947 Substrate binding site; other site 266264001948 metal-binding site 266264001949 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 266264001950 AzlC protein; Region: AzlC; cl00570 266264001951 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264001952 Phosphotransferase enzyme family; Region: APH; pfam01636 266264001953 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 266264001954 OstA-like protein; Region: OstA; cl00844 266264001955 OstA-like protein; Region: OstA; cl00844 266264001956 Organic solvent tolerance protein; Region: OstA_C; pfam04453 266264001957 SurA N-terminal domain; Region: SurA_N_3; cl07813 266264001958 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 266264001959 PPIC-type PPIASE domain; Region: Rotamase; cl08278 266264001960 PPIC-type PPIASE domain; Region: Rotamase; cl08278 266264001961 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 266264001962 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266264001963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264001964 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 266264001965 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 266264001966 active site 266264001967 HIGH motif; other site 266264001968 dimer interface [polypeptide binding]; other site 266264001969 KMSKS motif; other site 266264001970 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266264001971 EamA-like transporter family; Region: EamA; cl01037 266264001972 EamA-like transporter family; Region: EamA; cl01037 266264001973 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264001974 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 266264001975 dimer interface [polypeptide binding]; other site 266264001976 active site 266264001977 metal binding site [ion binding]; metal-binding site 266264001978 glutathione binding site [chemical binding]; other site 266264001979 Protein of unknown function DUF45; Region: DUF45; cl00636 266264001980 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266264001981 putative acyl-acceptor binding pocket; other site 266264001982 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 266264001983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264001984 active site 266264001985 motif I; other site 266264001986 motif II; other site 266264001987 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 266264001988 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 266264001989 dimer interface [polypeptide binding]; other site 266264001990 motif 1; other site 266264001991 active site 266264001992 motif 2; other site 266264001993 motif 3; other site 266264001994 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 266264001995 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 266264001996 putative active site [active] 266264001997 catalytic triad [active] 266264001998 putative dimer interface [polypeptide binding]; other site 266264001999 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 266264002000 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266264002001 Transporter associated domain; Region: CorC_HlyC; cl08393 266264002002 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 266264002003 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 266264002004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264002005 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 266264002006 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266264002007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264002008 FeS/SAM binding site; other site 266264002009 TRAM domain; Region: TRAM; cl01282 266264002010 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 266264002011 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 266264002012 Cl- selectivity filter; other site 266264002013 Cl- binding residues [ion binding]; other site 266264002014 pore gating glutamate residue; other site 266264002015 dimer interface [polypeptide binding]; other site 266264002016 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 266264002017 helicase 45; Provisional; Region: PTZ00424 266264002018 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266264002019 ATP binding site [chemical binding]; other site 266264002020 Mg++ binding site [ion binding]; other site 266264002021 motif III; other site 266264002022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264002023 nucleotide binding region [chemical binding]; other site 266264002024 ATP-binding site [chemical binding]; other site 266264002025 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264002026 Phosphotransferase enzyme family; Region: APH; pfam01636 266264002027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264002028 Ligand Binding Site [chemical binding]; other site 266264002029 transcriptional regulator FimZ; Provisional; Region: PRK09935 266264002030 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264002031 DNA binding residues [nucleotide binding] 266264002032 dimerization interface [polypeptide binding]; other site 266264002033 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 266264002034 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264002035 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264002036 catalytic residue [active] 266264002037 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264002038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264002039 putative substrate translocation pore; other site 266264002040 metabolite-proton symporter; Region: 2A0106; TIGR00883 266264002041 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 266264002042 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266264002043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264002044 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264002045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264002046 dimer interface [polypeptide binding]; other site 266264002047 phosphorylation site [posttranslational modification] 266264002048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264002049 ATP binding site [chemical binding]; other site 266264002050 Mg2+ binding site [ion binding]; other site 266264002051 G-X-G motif; other site 266264002052 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266264002053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002054 active site 266264002055 phosphorylation site [posttranslational modification] 266264002056 intermolecular recognition site; other site 266264002057 dimerization interface [polypeptide binding]; other site 266264002058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264002059 DNA binding site [nucleotide binding] 266264002060 recombinase A; Provisional; Region: recA; PRK09354 266264002061 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 266264002062 hexamer interface [polypeptide binding]; other site 266264002063 Walker A motif; other site 266264002064 ATP binding site [chemical binding]; other site 266264002065 Walker B motif; other site 266264002066 RecX family; Region: RecX; cl00936 266264002067 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266264002068 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 266264002069 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264002070 CoA-ligase; Region: Ligase_CoA; cl02894 266264002071 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266264002072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264002073 CoA-ligase; Region: Ligase_CoA; cl02894 266264002074 Integral membrane protein TerC family; Region: TerC; cl10468 266264002075 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 266264002076 Pilin (bacterial filament); Region: Pilin; pfam00114 266264002077 Pilin (bacterial filament); Region: Pilin; pfam00114 266264002078 O-Antigen ligase; Region: Wzy_C; cl04850 266264002079 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 266264002080 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 266264002081 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 266264002082 ABC transporter, ATP-binding protein-related protein 266264002083 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266264002084 MULE transposase domain; Region: MULE; pfam10551 266264002085 ABC transporter, ATP-binding protein-related protein 266264002086 Helix-turn-helix domains; Region: HTH; cl00088 266264002087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266264002088 Integrase core domain; Region: rve; cl01316 266264002089 transposase/IS protein; Provisional; Region: PRK09183 266264002090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002091 Walker A motif; other site 266264002092 ATP binding site [chemical binding]; other site 266264002093 Walker B motif; other site 266264002094 arginine finger; other site 266264002095 ser/tyr recombinase family protein (fragment) 266264002096 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 266264002097 trimer interface [polypeptide binding]; other site 266264002098 dimer interface [polypeptide binding]; other site 266264002099 putative active site [active] 266264002100 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 266264002101 Peptidase family M48; Region: Peptidase_M48; cl12018 266264002102 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 266264002103 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 266264002104 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264002105 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266264002106 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266264002107 putative active site [active] 266264002108 Zinc-finger domain; Region: zf-CHCC; cl01821 266264002109 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266264002110 homodimer interface [polypeptide binding]; other site 266264002111 substrate-cofactor binding pocket; other site 266264002112 catalytic residue [active] 266264002113 Probable chromatin-remodeling complex ATPase chain; Provisional; Region: PLN03142 266264002114 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264002115 ATP binding site [chemical binding]; other site 266264002116 putative Mg++ binding site [ion binding]; other site 266264002117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264002118 nucleotide binding region [chemical binding]; other site 266264002119 ATP-binding site [chemical binding]; other site 266264002120 amidase; Provisional; Region: PRK06170 266264002121 Amidase; Region: Amidase; cl11426 266264002122 benzoate transport; Region: 2A0115; TIGR00895 266264002123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264002124 putative substrate translocation pore; other site 266264002125 AzlC protein; Region: AzlC; cl00570 266264002126 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 266264002127 Helix-turn-helix domains; Region: HTH; cl00088 266264002128 Helix-turn-helix domains; Region: HTH; cl00088 266264002129 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 266264002130 Phosphoglycerate kinase; Region: PGK; pfam00162 266264002131 substrate binding site [chemical binding]; other site 266264002132 hinge regions; other site 266264002133 ADP binding site [chemical binding]; other site 266264002134 catalytic site [active] 266264002135 pyruvate kinase; Provisional; Region: PRK05826 266264002136 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266264002137 domain interfaces; other site 266264002138 active site 266264002139 hypothetical protein; Provisional; Region: PRK08185 266264002140 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266264002141 intersubunit interface [polypeptide binding]; other site 266264002142 active site 266264002143 zinc binding site [ion binding]; other site 266264002144 Na+ binding site [ion binding]; other site 266264002145 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 266264002146 ATP binding site [chemical binding]; other site 266264002147 active site 266264002148 substrate binding site [chemical binding]; other site 266264002149 AIR carboxylase; Region: AIRC; cl00310 266264002150 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 266264002151 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264002152 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 266264002153 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 266264002154 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 266264002155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264002156 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 266264002157 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 266264002158 Helix-turn-helix domains; Region: HTH; cl00088 266264002159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264002160 dimerization interface [polypeptide binding]; other site 266264002161 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264002162 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 266264002163 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 266264002164 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 266264002165 Protein export membrane protein; Region: SecD_SecF; cl14618 266264002166 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 266264002167 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264002168 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264002169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002170 active site 266264002171 phosphorylation site [posttranslational modification] 266264002172 intermolecular recognition site; other site 266264002173 dimerization interface [polypeptide binding]; other site 266264002174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264002175 DNA binding site [nucleotide binding] 266264002176 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 266264002177 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264002178 dimerization interface [polypeptide binding]; other site 266264002179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264002180 dimer interface [polypeptide binding]; other site 266264002181 phosphorylation site [posttranslational modification] 266264002182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264002183 ATP binding site [chemical binding]; other site 266264002184 Mg2+ binding site [ion binding]; other site 266264002185 G-X-G motif; other site 266264002186 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 266264002187 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 266264002188 putative deacylase active site [active] 266264002189 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 266264002190 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 266264002191 active site 266264002192 Int/Topo IB signature motif; other site 266264002193 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 266264002194 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266264002195 DNA binding site [nucleotide binding] 266264002196 active site 266264002197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264002198 NMT1-like family; Region: NMT1_2; cl15260 266264002199 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 266264002200 Membrane transport protein; Region: Mem_trans; cl09117 266264002201 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 266264002202 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 266264002203 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 266264002204 AMIN domain; Region: AMIN; pfam11741 266264002205 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 266264002206 active site 266264002207 metal binding site [ion binding]; metal-binding site 266264002208 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 266264002209 Membrane transport protein; Region: Mem_trans; cl09117 266264002210 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264002211 Helix-turn-helix domains; Region: HTH; cl00088 266264002212 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266264002213 putative dimerization interface [polypeptide binding]; other site 266264002214 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266264002215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264002216 S-adenosylmethionine binding site [chemical binding]; other site 266264002217 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264002218 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 266264002219 NAD binding site [chemical binding]; other site 266264002220 homodimer interface [polypeptide binding]; other site 266264002221 homotetramer interface [polypeptide binding]; other site 266264002222 active site 266264002223 adenylate kinase; Reviewed; Region: adk; PRK00279 266264002224 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 266264002225 AMP-binding site [chemical binding]; other site 266264002226 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 266264002227 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 266264002228 Ligand binding site; other site 266264002229 oligomer interface; other site 266264002230 Trm112p-like protein; Region: Trm112p; cl01066 266264002231 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 266264002232 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 266264002233 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 266264002234 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266264002235 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 266264002236 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 266264002237 generic binding surface II; other site 266264002238 generic binding surface I; other site 266264002239 superoxide dismutase; Provisional; Region: PRK10543 266264002240 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 266264002241 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266264002242 Helix-turn-helix domains; Region: HTH; cl00088 266264002243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264002244 D-galactonate transporter; Region: 2A0114; TIGR00893 266264002245 putative substrate translocation pore; other site 266264002246 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266264002247 dinuclear metal binding motif [ion binding]; other site 266264002248 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 266264002249 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 266264002250 FAD binding pocket [chemical binding]; other site 266264002251 FAD binding motif [chemical binding]; other site 266264002252 phosphate binding motif [ion binding]; other site 266264002253 beta-alpha-beta structure motif; other site 266264002254 NAD(p) ribose binding residues [chemical binding]; other site 266264002255 NAD binding pocket [chemical binding]; other site 266264002256 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 266264002257 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264002258 catalytic loop [active] 266264002259 iron binding site [ion binding]; other site 266264002260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264002261 Helix-turn-helix domains; Region: HTH; cl00088 266264002262 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 266264002263 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 266264002264 NAD binding site [chemical binding]; other site 266264002265 catalytic Zn binding site [ion binding]; other site 266264002266 substrate binding site [chemical binding]; other site 266264002267 structural Zn binding site [ion binding]; other site 266264002268 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 266264002269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264002270 NAD(P) binding site [chemical binding]; other site 266264002271 active site 266264002272 Citrate transporter; Region: CitMHS; pfam03600 266264002273 PAS fold; Region: PAS_4; pfam08448 266264002274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264002275 putative active site [active] 266264002276 heme pocket [chemical binding]; other site 266264002277 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 266264002278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002279 Walker A motif; other site 266264002280 ATP binding site [chemical binding]; other site 266264002281 Walker B motif; other site 266264002282 arginine finger; other site 266264002283 Helix-turn-helix domains; Region: HTH; cl00088 266264002284 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 266264002285 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 266264002286 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 266264002287 Peptidase M30; Region: Peptidase_M30; pfam10460 266264002288 Helix-turn-helix domains; Region: HTH; cl00088 266264002289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264002290 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 266264002291 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 266264002292 putative dimer interface [polypeptide binding]; other site 266264002293 [2Fe-2S] cluster binding site [ion binding]; other site 266264002294 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 266264002295 putative dimer interface [polypeptide binding]; other site 266264002296 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266264002297 SLBB domain; Region: SLBB; pfam10531 266264002298 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 266264002299 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 266264002300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264002301 catalytic loop [active] 266264002302 iron binding site [ion binding]; other site 266264002303 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 266264002304 4Fe-4S binding domain; Region: Fer4; cl02805 266264002305 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 266264002306 [4Fe-4S] binding site [ion binding]; other site 266264002307 molybdopterin cofactor binding site; other site 266264002308 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 266264002309 molybdopterin cofactor binding site; other site 266264002310 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 266264002311 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 266264002312 Transglycosylase; Region: Transgly; cl07896 266264002313 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266264002314 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266264002315 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266264002316 transmembrane helices; other site 266264002317 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 266264002318 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 266264002319 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 266264002320 acetate kinase; Region: ackA; TIGR00016 266264002321 Acetokinase family; Region: Acetate_kinase; cl01029 266264002322 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 266264002323 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 266264002324 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 266264002325 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266264002326 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 266264002327 NAD binding site [chemical binding]; other site 266264002328 homotetramer interface [polypeptide binding]; other site 266264002329 homodimer interface [polypeptide binding]; other site 266264002330 substrate binding site [chemical binding]; other site 266264002331 active site 266264002332 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586 266264002333 Helix-turn-helix domains; Region: HTH; cl00088 266264002334 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 266264002335 TOBE domain; Region: TOBE_2; cl01440 266264002336 TOBE domain; Region: TOBE_2; cl01440 266264002337 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 266264002338 putative active site [active] 266264002339 putative metal binding residues [ion binding]; other site 266264002340 signature motif; other site 266264002341 putative triphosphate binding site [ion binding]; other site 266264002342 dimer interface [polypeptide binding]; other site 266264002343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264002344 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 266264002345 Walker A/P-loop; other site 266264002346 ATP binding site [chemical binding]; other site 266264002347 Q-loop/lid; other site 266264002348 ABC transporter signature motif; other site 266264002349 Walker B; other site 266264002350 D-loop; other site 266264002351 H-loop/switch region; other site 266264002352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264002353 dimer interface [polypeptide binding]; other site 266264002354 conserved gate region; other site 266264002355 putative PBP binding loops; other site 266264002356 ABC-ATPase subunit interface; other site 266264002357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264002358 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266264002359 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 266264002360 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 266264002361 active site 266264002362 metal binding site [ion binding]; metal-binding site 266264002363 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266264002364 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266264002365 Sel1 repeat; Region: Sel1; cl02723 266264002366 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266264002367 PapC N-terminal domain; Region: PapC_N; pfam13954 266264002368 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266264002369 PapC C-terminal domain; Region: PapC_C; pfam13953 266264002370 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 266264002371 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266264002372 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266264002373 Fimbrial protein; Region: Fimbrial; cl01416 266264002374 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16918 266264002375 Protein of unknown function (DUF330); Region: DUF330; cl01135 266264002376 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 266264002377 mce related protein; Region: MCE; pfam02470 266264002378 mce related protein; Region: MCE; pfam02470 266264002379 Paraquat-inducible protein A; Region: PqiA; pfam04403 266264002380 Paraquat-inducible protein A; Region: PqiA; pfam04403 266264002381 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 266264002382 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266264002383 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 266264002384 HPP family; Region: HPP; pfam04982 266264002385 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 266264002386 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 266264002387 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 266264002388 Cl- selectivity filter; other site 266264002389 Cl- binding residues [ion binding]; other site 266264002390 pore gating glutamate residue; other site 266264002391 dimer interface [polypeptide binding]; other site 266264002392 FOG: CBS domain [General function prediction only]; Region: COG0517 266264002393 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 266264002394 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 266264002395 Amidinotransferase; Region: Amidinotransf; cl12043 266264002396 ornithine cyclodeaminase; Validated; Region: PRK07589 266264002397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264002398 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 266264002399 DNA binding residues [nucleotide binding] 266264002400 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264002401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002402 active site 266264002403 phosphorylation site [posttranslational modification] 266264002404 intermolecular recognition site; other site 266264002405 dimerization interface [polypeptide binding]; other site 266264002406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002407 Walker A motif; other site 266264002408 ATP binding site [chemical binding]; other site 266264002409 Walker B motif; other site 266264002410 Helix-turn-helix domains; Region: HTH; cl00088 266264002411 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266264002412 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264002413 dimer interface [polypeptide binding]; other site 266264002414 phosphorylation site [posttranslational modification] 266264002415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264002416 ATP binding site [chemical binding]; other site 266264002417 Mg2+ binding site [ion binding]; other site 266264002418 G-X-G motif; other site 266264002419 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266264002420 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 266264002421 MASE1; Region: MASE1; pfam05231 266264002422 putative diguanylate cyclase; Provisional; Region: PRK09776 266264002423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264002424 putative active site [active] 266264002425 heme pocket [chemical binding]; other site 266264002426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264002427 putative active site [active] 266264002428 heme pocket [chemical binding]; other site 266264002429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264002430 putative active site [active] 266264002431 heme pocket [chemical binding]; other site 266264002432 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264002433 metal binding site [ion binding]; metal-binding site 266264002434 active site 266264002435 I-site; other site 266264002436 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264002437 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264002438 Cytochrome c; Region: Cytochrom_C; cl11414 266264002439 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266264002440 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266264002441 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266264002442 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266264002443 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264002444 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264002445 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266264002446 Putative zinc-finger; Region: zf-HC2; cl15806 266264002447 RNA polymerase sigma factor; Provisional; Region: PRK12533 266264002448 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264002449 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266264002450 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264002451 active site 266264002452 metal binding site [ion binding]; metal-binding site 266264002453 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264002454 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 266264002455 Protein export membrane protein; Region: SecD_SecF; cl14618 266264002456 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 266264002457 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264002458 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264002459 MASE1; Region: MASE1; pfam05231 266264002460 PAS fold; Region: PAS_3; pfam08447 266264002461 Esterase/lipase [General function prediction only]; Region: COG1647 266264002462 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264002463 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264002464 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 266264002465 active site 266264002466 nucleophile elbow; other site 266264002467 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266264002468 Surface antigen; Region: Bac_surface_Ag; cl03097 266264002469 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264002470 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264002471 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264002472 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264002473 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 266264002474 active site 266264002475 catalytic residues [active] 266264002476 metal binding site [ion binding]; metal-binding site 266264002477 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266264002478 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264002479 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266264002480 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264002481 carboxyltransferase (CT) interaction site; other site 266264002482 biotinylation site [posttranslational modification]; other site 266264002483 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266264002484 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266264002485 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266264002486 AMP-binding domain protein; Validated; Region: PRK08315 266264002487 AMP-binding enzyme; Region: AMP-binding; cl15778 266264002488 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264002489 Helix-turn-helix domains; Region: HTH; cl00088 266264002490 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264002491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002492 active site 266264002493 phosphorylation site [posttranslational modification] 266264002494 intermolecular recognition site; other site 266264002495 dimerization interface [polypeptide binding]; other site 266264002496 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264002497 DNA binding residues [nucleotide binding] 266264002498 dimerization interface [polypeptide binding]; other site 266264002499 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 266264002500 Histidine kinase; Region: HisKA_3; pfam07730 266264002501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 266264002502 haemagglutination activity domain; Region: Haemagg_act; cl05436 266264002503 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 266264002504 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 266264002505 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 266264002506 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 266264002507 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 266264002508 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266264002509 oligomerisation interface [polypeptide binding]; other site 266264002510 mobile loop; other site 266264002511 roof hairpin; other site 266264002512 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266264002513 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266264002514 ring oligomerisation interface [polypeptide binding]; other site 266264002515 ATP/Mg binding site [chemical binding]; other site 266264002516 stacking interactions; other site 266264002517 hinge regions; other site 266264002518 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 266264002519 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 266264002520 Clp amino terminal domain; Region: Clp_N; pfam02861 266264002521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002522 Walker A motif; other site 266264002523 ATP binding site [chemical binding]; other site 266264002524 Walker B motif; other site 266264002525 arginine finger; other site 266264002526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002527 Walker A motif; other site 266264002528 ATP binding site [chemical binding]; other site 266264002529 Walker B motif; other site 266264002530 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 266264002531 Protein of unknown function (DUF796); Region: DUF796; cl01226 266264002532 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266264002533 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264002534 ligand binding site [chemical binding]; other site 266264002535 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 266264002536 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 266264002537 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 266264002538 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 266264002539 Protein of unknown function (DUF877); Region: DUF877; pfam05943 266264002540 Protein of unknown function (DUF770); Region: DUF770; cl01402 266264002541 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 266264002542 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 266264002543 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266264002544 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 266264002545 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 266264002546 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266264002547 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266264002548 putative active site [active] 266264002549 catalytic site [active] 266264002550 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266264002551 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 266264002552 putative active site [active] 266264002553 catalytic site [active] 266264002554 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266264002555 Sel1 repeat; Region: Sel1; cl02723 266264002556 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266264002557 Sel1 repeat; Region: Sel1; cl02723 266264002558 PAAR motif; Region: PAAR_motif; cl15808 266264002559 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 266264002560 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 266264002561 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 266264002562 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 266264002563 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 266264002564 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 266264002565 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 266264002566 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 266264002567 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264002568 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 266264002569 putative active site [active] 266264002570 putative metal binding site [ion binding]; other site 266264002571 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264002572 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266264002573 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264002574 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266264002575 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266264002576 ATP binding site [chemical binding]; other site 266264002577 Walker A motif; other site 266264002578 hexamer interface [polypeptide binding]; other site 266264002579 Walker B motif; other site 266264002580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002581 active site 266264002582 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 266264002583 phosphorylation site [posttranslational modification] 266264002584 intermolecular recognition site; other site 266264002585 dimerization interface [polypeptide binding]; other site 266264002586 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264002587 TadE-like protein; Region: TadE; cl10688 266264002588 TadE-like protein; Region: TadE; cl10688 266264002589 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266264002590 TadE-like protein; Region: TadE; cl10688 266264002591 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266264002592 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266264002593 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264002594 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266264002595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002596 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264002597 Walker A motif; other site 266264002598 ATP binding site [chemical binding]; other site 266264002599 Walker B motif; other site 266264002600 chromosomal replication initiation protein; Provisional; Region: PRK12422 266264002601 arginine finger; other site 266264002602 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 266264002603 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266264002604 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266264002605 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266264002606 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 266264002607 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 266264002608 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266264002609 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266264002610 Ligand binding site; other site 266264002611 Putative Catalytic site; other site 266264002612 DXD motif; other site 266264002613 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 266264002614 GtrA-like protein; Region: GtrA; cl00971 266264002615 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264002616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002617 Walker A motif; other site 266264002618 ATP binding site [chemical binding]; other site 266264002619 Walker B motif; other site 266264002620 arginine finger; other site 266264002621 Helix-turn-helix domains; Region: HTH; cl00088 266264002622 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264002623 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264002624 dimerization interface [polypeptide binding]; other site 266264002625 substrate binding pocket [chemical binding]; other site 266264002626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264002627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264002628 putative substrate translocation pore; other site 266264002629 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 266264002630 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266264002631 Repair protein; Region: Repair_PSII; cl01535 266264002632 Repair protein; Region: Repair_PSII; cl01535 266264002633 LemA family; Region: LemA; cl00742 266264002634 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266264002635 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266264002636 dimer interface [polypeptide binding]; other site 266264002637 active site 266264002638 catalytic residue [active] 266264002639 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 266264002640 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264002641 inhibitor-cofactor binding pocket; inhibition site 266264002642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264002643 catalytic residue [active] 266264002644 Rubredoxin [Energy production and conversion]; Region: COG1773 266264002645 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266264002646 iron binding site [ion binding]; other site 266264002647 Response regulator receiver domain; Region: Response_reg; pfam00072 266264002648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002649 active site 266264002650 phosphorylation site [posttranslational modification] 266264002651 intermolecular recognition site; other site 266264002652 dimerization interface [polypeptide binding]; other site 266264002653 Response regulator receiver domain; Region: Response_reg; pfam00072 266264002654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002655 active site 266264002656 phosphorylation site [posttranslational modification] 266264002657 intermolecular recognition site; other site 266264002658 dimerization interface [polypeptide binding]; other site 266264002659 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 266264002660 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 266264002661 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264002662 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264002663 dimer interface [polypeptide binding]; other site 266264002664 putative CheW interface [polypeptide binding]; other site 266264002665 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264002666 putative binding surface; other site 266264002667 active site 266264002668 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264002669 putative binding surface; other site 266264002670 active site 266264002671 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264002672 putative binding surface; other site 266264002673 active site 266264002674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264002675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264002676 ATP binding site [chemical binding]; other site 266264002677 Mg2+ binding site [ion binding]; other site 266264002678 G-X-G motif; other site 266264002679 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 266264002680 Response regulator receiver domain; Region: Response_reg; pfam00072 266264002681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002682 active site 266264002683 phosphorylation site [posttranslational modification] 266264002684 intermolecular recognition site; other site 266264002685 dimerization interface [polypeptide binding]; other site 266264002686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264002687 D-galactonate transporter; Region: 2A0114; TIGR00893 266264002688 putative substrate translocation pore; other site 266264002689 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 266264002690 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264002691 putative NAD(P) binding site [chemical binding]; other site 266264002692 active site 266264002693 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264002694 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 266264002695 NAD(P) binding site [chemical binding]; other site 266264002696 catalytic residues [active] 266264002697 catalytic residues [active] 266264002698 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 266264002699 dimer interface [polypeptide binding]; other site 266264002700 substrate binding site [chemical binding]; other site 266264002701 metal binding sites [ion binding]; metal-binding site 266264002702 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264002703 Protein of unknown function, DUF482; Region: DUF482; pfam04339 266264002704 NAD synthetase; Reviewed; Region: nadE; PRK02628 266264002705 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 266264002706 multimer interface [polypeptide binding]; other site 266264002707 active site 266264002708 catalytic triad [active] 266264002709 protein interface 1 [polypeptide binding]; other site 266264002710 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266264002711 homodimer interface [polypeptide binding]; other site 266264002712 NAD binding pocket [chemical binding]; other site 266264002713 ATP binding pocket [chemical binding]; other site 266264002714 Mg binding site [ion binding]; other site 266264002715 active-site loop [active] 266264002716 Nitrogen regulatory protein P-II; Region: P-II; cl00412 266264002717 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266264002718 Predicted membrane protein [Function unknown]; Region: COG2860 266264002719 UPF0126 domain; Region: UPF0126; pfam03458 266264002720 UPF0126 domain; Region: UPF0126; pfam03458 266264002721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 266264002722 Smr domain; Region: Smr; cl02619 266264002723 thioredoxin reductase; Provisional; Region: PRK10262 266264002724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264002725 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 266264002726 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264002727 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 266264002728 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 266264002729 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 266264002730 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264002731 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264002732 substrate binding pocket [chemical binding]; other site 266264002733 membrane-bound complex binding site; other site 266264002734 hinge residues; other site 266264002735 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266264002736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264002737 dimer interface [polypeptide binding]; other site 266264002738 conserved gate region; other site 266264002739 putative PBP binding loops; other site 266264002740 ABC-ATPase subunit interface; other site 266264002741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264002742 dimer interface [polypeptide binding]; other site 266264002743 conserved gate region; other site 266264002744 putative PBP binding loops; other site 266264002745 ABC-ATPase subunit interface; other site 266264002746 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266264002747 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 266264002748 Walker A/P-loop; other site 266264002749 ATP binding site [chemical binding]; other site 266264002750 Q-loop/lid; other site 266264002751 ABC transporter signature motif; other site 266264002752 Walker B; other site 266264002753 D-loop; other site 266264002754 H-loop/switch region; other site 266264002755 recombination factor protein RarA; Reviewed; Region: PRK13342 266264002756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002757 Walker A motif; other site 266264002758 ATP binding site [chemical binding]; other site 266264002759 Walker B motif; other site 266264002760 arginine finger; other site 266264002761 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 266264002762 seryl-tRNA synthetase; Provisional; Region: PRK05431 266264002763 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 266264002764 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 266264002765 dimer interface [polypeptide binding]; other site 266264002766 active site 266264002767 motif 1; other site 266264002768 motif 2; other site 266264002769 motif 3; other site 266264002770 serine-based site-specific recombinase (fragment) 266264002771 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 266264002772 putative major pilin subunit; Provisional; Region: PRK10574 266264002773 Pilin (bacterial filament); Region: Pilin; pfam00114 266264002774 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266264002775 Domain of unknown function DUF21; Region: DUF21; pfam01595 266264002776 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266264002777 Transporter associated domain; Region: CorC_HlyC; cl08393 266264002778 Helix-turn-helix domains; Region: HTH; cl00088 266264002779 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 266264002780 putative dimerization interface [polypeptide binding]; other site 266264002781 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266264002782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264002783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264002784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264002785 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264002786 substrate binding pocket [chemical binding]; other site 266264002787 membrane-bound complex binding site; other site 266264002788 hinge residues; other site 266264002789 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 266264002790 putative hydrophobic ligand binding site [chemical binding]; other site 266264002791 cyanophycin synthetase; Provisional; Region: PRK14016 266264002792 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264002793 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264002794 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264002795 cyanophycin synthetase; Provisional; Region: PRK14016 266264002796 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264002797 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264002798 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264002799 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 266264002800 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266264002801 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 266264002802 Walker A/P-loop; other site 266264002803 ATP binding site [chemical binding]; other site 266264002804 Q-loop/lid; other site 266264002805 ABC transporter signature motif; other site 266264002806 Walker B; other site 266264002807 D-loop; other site 266264002808 H-loop/switch region; other site 266264002809 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 266264002810 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266264002811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264002812 motif II; other site 266264002813 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 266264002814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264002815 S-adenosylmethionine binding site [chemical binding]; other site 266264002816 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264002817 ligand binding site [chemical binding]; other site 266264002818 DNA gyrase subunit A; Validated; Region: PRK05560 266264002819 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 266264002820 CAP-like domain; other site 266264002821 active site 266264002822 primary dimer interface [polypeptide binding]; other site 266264002823 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002824 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002825 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002826 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002827 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002828 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002829 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 266264002830 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 266264002831 homodimer interface [polypeptide binding]; other site 266264002832 substrate-cofactor binding pocket; other site 266264002833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264002834 catalytic residue [active] 266264002835 Chorismate mutase type II; Region: CM_2; cl00693 266264002836 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 266264002837 Prephenate dehydratase; Region: PDT; pfam00800 266264002838 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 266264002839 putative L-Phe binding site [chemical binding]; other site 266264002840 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 266264002841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264002842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264002843 homodimer interface [polypeptide binding]; other site 266264002844 catalytic residue [active] 266264002845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264002846 Prephenate dehydrogenase; Region: PDH; pfam02153 266264002847 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 266264002848 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 266264002849 hinge; other site 266264002850 active site 266264002851 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 266264002852 cytidylate kinase; Provisional; Region: cmk; PRK00023 266264002853 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 266264002854 CMP-binding site; other site 266264002855 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 266264002856 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 266264002857 RNA binding site [nucleotide binding]; other site 266264002858 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 266264002859 RNA binding site [nucleotide binding]; other site 266264002860 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 266264002861 RNA binding site [nucleotide binding]; other site 266264002862 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 266264002863 RNA binding site [nucleotide binding]; other site 266264002864 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 266264002865 RNA binding site [nucleotide binding]; other site 266264002866 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 266264002867 RNA binding site [nucleotide binding]; other site 266264002868 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266264002869 IHF dimer interface [polypeptide binding]; other site 266264002870 IHF - DNA interface [nucleotide binding]; other site 266264002871 tetratricopeptide repeat protein; Provisional; Region: PRK11788 266264002872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264002873 binding surface 266264002874 TPR motif; other site 266264002875 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266264002876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264002877 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266264002878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264002879 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 266264002880 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266264002881 putative ribose interaction site [chemical binding]; other site 266264002882 putative ADP binding site [chemical binding]; other site 266264002883 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 266264002884 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 266264002885 NADP binding site [chemical binding]; other site 266264002886 homopentamer interface [polypeptide binding]; other site 266264002887 substrate binding site [chemical binding]; other site 266264002888 active site 266264002889 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 266264002890 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 266264002891 cysteine synthase B; Region: cysM; TIGR01138 266264002892 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266264002893 dimer interface [polypeptide binding]; other site 266264002894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264002895 catalytic residue [active] 266264002896 Transglycosylase SLT domain; Region: SLT_2; pfam13406 266264002897 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266264002898 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264002899 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266264002900 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 266264002901 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 266264002902 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 266264002903 Walker A/P-loop; other site 266264002904 ATP binding site [chemical binding]; other site 266264002905 Q-loop/lid; other site 266264002906 ABC transporter signature motif; other site 266264002907 Walker B; other site 266264002908 D-loop; other site 266264002909 H-loop/switch region; other site 266264002910 NIL domain; Region: NIL; cl09633 266264002911 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 266264002912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264002913 ABC-ATPase subunit interface; other site 266264002914 NMT1-like family; Region: NMT1_2; cl15260 266264002915 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266264002916 Ligand binding site [chemical binding]; other site 266264002917 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266264002918 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 266264002919 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266264002920 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266264002921 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266264002922 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266264002923 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264002924 active site 266264002925 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266264002926 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266264002927 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264002928 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 266264002929 Helix-turn-helix domains; Region: HTH; cl00088 266264002930 AsnC family; Region: AsnC_trans_reg; pfam01037 266264002931 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 266264002932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264002933 FeS/SAM binding site; other site 266264002934 transcriptional activator TtdR; Provisional; Region: PRK09801 266264002935 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264002936 putative effector binding pocket; other site 266264002937 dimerization interface [polypeptide binding]; other site 266264002938 TM2 domain; Region: TM2; cl00984 266264002939 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 266264002940 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 266264002941 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 266264002942 RimM N-terminal domain; Region: RimM; pfam01782 266264002943 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 266264002944 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 266264002945 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 266264002946 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 266264002947 putative active site [active] 266264002948 putative CoA binding site [chemical binding]; other site 266264002949 nudix motif; other site 266264002950 metal binding site [ion binding]; metal-binding site 266264002951 rhodanese superfamily protein; Provisional; Region: PRK05320 266264002952 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 266264002953 active site residue [active] 266264002954 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 266264002955 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 266264002956 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266264002957 generic binding surface II; other site 266264002958 generic binding surface I; other site 266264002959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264002960 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 266264002961 putative ADP-binding pocket [chemical binding]; other site 266264002962 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266264002963 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 266264002964 putative metal binding site; other site 266264002965 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 266264002966 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266264002967 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 266264002968 Walker A/P-loop; other site 266264002969 ATP binding site [chemical binding]; other site 266264002970 Q-loop/lid; other site 266264002971 ABC transporter signature motif; other site 266264002972 Walker B; other site 266264002973 D-loop; other site 266264002974 H-loop/switch region; other site 266264002975 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266264002976 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264002977 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264002978 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 266264002979 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264002980 active site 266264002981 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 266264002982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264002983 Walker A/P-loop; other site 266264002984 ATP binding site [chemical binding]; other site 266264002985 Q-loop/lid; other site 266264002986 ABC transporter signature motif; other site 266264002987 Walker B; other site 266264002988 D-loop; other site 266264002989 H-loop/switch region; other site 266264002990 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 266264002991 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264002992 Walker A/P-loop; other site 266264002993 ATP binding site [chemical binding]; other site 266264002994 Q-loop/lid; other site 266264002995 ABC transporter signature motif; other site 266264002996 Walker B; other site 266264002997 D-loop; other site 266264002998 H-loop/switch region; other site 266264002999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264003000 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 266264003001 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 266264003002 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 266264003003 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 266264003004 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 266264003005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264003006 DNA-binding site [nucleotide binding]; DNA binding site 266264003007 UTRA domain; Region: UTRA; cl01230 266264003008 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 266264003009 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264003010 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266264003011 active site 266264003012 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 266264003013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264003014 Guanylate kinase; Region: Guanylate_kin; pfam00625 266264003015 active site 266264003016 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264003017 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266264003018 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 266264003019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264003020 dimer interface [polypeptide binding]; other site 266264003021 conserved gate region; other site 266264003022 putative PBP binding loops; other site 266264003023 ABC-ATPase subunit interface; other site 266264003024 NMT1-like family; Region: NMT1_2; cl15260 266264003025 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 266264003026 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 266264003027 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 266264003028 Walker A/P-loop; other site 266264003029 ATP binding site [chemical binding]; other site 266264003030 Q-loop/lid; other site 266264003031 ABC transporter signature motif; other site 266264003032 Walker B; other site 266264003033 D-loop; other site 266264003034 H-loop/switch region; other site 266264003035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264003036 D-galactonate transporter; Region: 2A0114; TIGR00893 266264003037 putative substrate translocation pore; other site 266264003038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264003039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264003040 putative substrate translocation pore; other site 266264003041 ribonuclease G; Provisional; Region: PRK11712 266264003042 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 266264003043 homodimer interface [polypeptide binding]; other site 266264003044 oligonucleotide binding site [chemical binding]; other site 266264003045 Maf-like protein; Region: Maf; pfam02545 266264003046 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266264003047 active site 266264003048 dimer interface [polypeptide binding]; other site 266264003049 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 266264003050 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 266264003051 Oligomerisation domain; Region: Oligomerisation; cl00519 266264003052 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 266264003053 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 266264003054 active site 266264003055 (T/H)XGH motif; other site 266264003056 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 266264003057 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 266264003058 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 266264003059 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264003060 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 266264003061 Transcriptional regulator; Region: Transcrip_reg; cl00361 266264003062 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 266264003063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264003064 Walker A motif; other site 266264003065 ATP binding site [chemical binding]; other site 266264003066 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 266264003067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264003068 active site 266264003069 NMT1-like family; Region: NMT1_2; cl15260 266264003070 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266264003071 EamA-like transporter family; Region: EamA; cl01037 266264003072 EamA-like transporter family; Region: EamA; cl01037 266264003073 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266264003074 putative NAD(P) binding site [chemical binding]; other site 266264003075 putative active site [active] 266264003076 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 266264003077 active site 266264003078 dimer interfaces [polypeptide binding]; other site 266264003079 catalytic residues [active] 266264003080 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 266264003081 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266264003082 putative ligand binding site [chemical binding]; other site 266264003083 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266264003084 TM-ABC transporter signature motif; other site 266264003085 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266264003086 TM-ABC transporter signature motif; other site 266264003087 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266264003088 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266264003089 Walker A/P-loop; other site 266264003090 ATP binding site [chemical binding]; other site 266264003091 Q-loop/lid; other site 266264003092 ABC transporter signature motif; other site 266264003093 Walker B; other site 266264003094 D-loop; other site 266264003095 H-loop/switch region; other site 266264003096 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266264003097 Pirin-related protein [General function prediction only]; Region: COG1741 266264003098 Cupin domain; Region: Cupin_2; cl09118 266264003099 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266264003100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264003101 dimer interface [polypeptide binding]; other site 266264003102 conserved gate region; other site 266264003103 putative PBP binding loops; other site 266264003104 ABC-ATPase subunit interface; other site 266264003105 NMT1-like family; Region: NMT1_2; cl15260 266264003106 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266264003107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264003108 dimer interface [polypeptide binding]; other site 266264003109 conserved gate region; other site 266264003110 ABC-ATPase subunit interface; other site 266264003111 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 266264003112 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 266264003113 Walker A/P-loop; other site 266264003114 ATP binding site [chemical binding]; other site 266264003115 Q-loop/lid; other site 266264003116 ABC transporter signature motif; other site 266264003117 Walker B; other site 266264003118 D-loop; other site 266264003119 H-loop/switch region; other site 266264003120 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 266264003121 FOG: CBS domain [General function prediction only]; Region: COG0517 266264003122 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266264003123 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 266264003124 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 266264003125 active site residues [active] 266264003126 dimer interface [polypeptide binding]; other site 266264003127 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 266264003128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264003129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264003130 putative substrate translocation pore; other site 266264003131 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266264003132 intersubunit interface [polypeptide binding]; other site 266264003133 active site 266264003134 Zn2+ binding site [ion binding]; other site 266264003135 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266264003136 active site 1 [active] 266264003137 dimer interface [polypeptide binding]; other site 266264003138 hexamer interface [polypeptide binding]; other site 266264003139 active site 2 [active] 266264003140 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 266264003141 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 266264003142 tetramer interface [polypeptide binding]; other site 266264003143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264003144 catalytic residue [active] 266264003145 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266264003146 nudix motif; other site 266264003147 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 266264003148 CPxP motif; other site 266264003149 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 266264003150 YaeQ protein; Region: YaeQ; cl01913 266264003151 YceI-like domain; Region: YceI; cl01001 266264003152 MAPEG family; Region: MAPEG; cl09190 266264003153 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 266264003154 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 266264003155 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264003156 active site 266264003157 HIGH motif; other site 266264003158 nucleotide binding site [chemical binding]; other site 266264003159 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 266264003160 KMSKS motif; other site 266264003161 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 266264003162 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264003163 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264003164 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266264003165 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 266264003166 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 266264003167 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266264003168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264003169 NMT1-like family; Region: NMT1_2; cl15260 266264003170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264003171 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264003172 dimerization interface [polypeptide binding]; other site 266264003173 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266264003174 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266264003175 potassium/proton antiporter; Reviewed; Region: PRK05326 266264003176 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266264003177 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266264003178 Transporter associated domain; Region: CorC_HlyC; cl08393 266264003179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264003180 NMT1-like family; Region: NMT1_2; cl15260 266264003181 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 266264003182 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264003183 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264003184 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 266264003185 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 266264003186 motif 1; other site 266264003187 active site 266264003188 motif 2; other site 266264003189 motif 3; other site 266264003190 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 266264003191 DHHA1 domain; Region: DHHA1; pfam02272 266264003192 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 266264003193 dimer interface [polypeptide binding]; other site 266264003194 NADP binding site [chemical binding]; other site 266264003195 catalytic residues [active] 266264003196 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264003197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264003198 DNA-binding site [nucleotide binding]; DNA binding site 266264003199 FCD domain; Region: FCD; cl11656 266264003200 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 266264003201 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 266264003202 active site 266264003203 tetramer interface [polypeptide binding]; other site 266264003204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264003205 NMT1-like family; Region: NMT1_2; cl15260 266264003206 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 266264003207 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264003208 N-terminal plug; other site 266264003209 ligand-binding site [chemical binding]; other site 266264003210 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264003211 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 266264003212 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 266264003213 active site 266264003214 substrate binding site [chemical binding]; other site 266264003215 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 266264003216 FMN binding site [chemical binding]; other site 266264003217 putative catalytic residues [active] 266264003218 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264003219 Helix-turn-helix domains; Region: HTH; cl00088 266264003220 enoyl-CoA hydratase; Provisional; Region: PRK08290 266264003221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264003222 substrate binding site [chemical binding]; other site 266264003223 oxyanion hole (OAH) forming residues; other site 266264003224 trimer interface [polypeptide binding]; other site 266264003225 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 266264003226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264003227 CoA-ligase; Region: Ligase_CoA; cl02894 266264003228 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264003229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264003230 NMT1-like family; Region: NMT1_2; cl15260 266264003231 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266264003232 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264003233 active site 266264003234 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264003235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264003236 active site 266264003237 Abortive infection C-terminus; Region: Abi_C; pfam14355 266264003238 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 266264003239 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264003240 FeS/SAM binding site; other site 266264003241 HemN C-terminal domain; Region: HemN_C; pfam06969 266264003242 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 266264003243 active site 266264003244 dimerization interface [polypeptide binding]; other site 266264003245 ribonuclease PH; Reviewed; Region: rph; PRK00173 266264003246 Ribonuclease PH; Region: RNase_PH_bact; cd11362 266264003247 hexamer interface [polypeptide binding]; other site 266264003248 active site 266264003249 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 266264003250 Protein phosphatase 2C; Region: PP2C; pfam00481 266264003251 active site 266264003252 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266264003253 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266264003254 active site 266264003255 ATP binding site [chemical binding]; other site 266264003256 substrate binding site [chemical binding]; other site 266264003257 activation loop (A-loop); other site 266264003258 hypothetical protein; Provisional; Region: PRK11820 266264003259 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 266264003260 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 266264003261 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 266264003262 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 266264003263 catalytic site [active] 266264003264 G-X2-G-X-G-K; other site 266264003265 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 266264003266 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266264003267 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266264003268 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266264003269 synthetase active site [active] 266264003270 NTP binding site [chemical binding]; other site 266264003271 metal binding site [ion binding]; metal-binding site 266264003272 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266264003273 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266264003274 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 266264003275 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266264003276 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266264003277 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 266264003278 Cupin domain; Region: Cupin_2; cl09118 266264003279 PAS domain; Region: PAS_9; pfam13426 266264003280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264003281 PAS domain; Region: PAS_9; pfam13426 266264003282 putative active site [active] 266264003283 heme pocket [chemical binding]; other site 266264003284 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264003285 metal binding site [ion binding]; metal-binding site 266264003286 active site 266264003287 I-site; other site 266264003288 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264003289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264003290 DNA-binding site [nucleotide binding]; DNA binding site 266264003291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264003292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264003293 homodimer interface [polypeptide binding]; other site 266264003294 catalytic residue [active] 266264003295 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 266264003296 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266264003297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264003298 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 266264003299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264003300 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266264003301 Protein of unknown function (DUF342); Region: DUF342; pfam03961 266264003302 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 266264003303 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 266264003304 AMP binding site [chemical binding]; other site 266264003305 metal binding site [ion binding]; metal-binding site 266264003306 active site 266264003307 aminopeptidase N; Provisional; Region: pepN; PRK14015 266264003308 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 266264003309 active site 266264003310 Zn binding site [ion binding]; other site 266264003311 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 266264003312 malic enzyme; Reviewed; Region: PRK12862 266264003313 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266264003314 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266264003315 putative NAD(P) binding site [chemical binding]; other site 266264003316 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 266264003317 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264003318 trimer interface [polypeptide binding]; other site 266264003319 eyelet of channel; other site 266264003320 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 266264003321 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 266264003322 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 266264003323 active site 266264003324 catalytic site [active] 266264003325 tetramer interface [polypeptide binding]; other site 266264003326 xanthine permease; Region: pbuX; TIGR03173 266264003327 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264003328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264003329 DNA-binding site [nucleotide binding]; DNA binding site 266264003330 FCD domain; Region: FCD; cl11656 266264003331 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 266264003332 active site 266264003333 homotetramer interface [polypeptide binding]; other site 266264003334 Predicted membrane protein [Function unknown]; Region: COG3748 266264003335 Protein of unknown function (DUF989); Region: DUF989; pfam06181 266264003336 Cytochrome c; Region: Cytochrom_C; cl11414 266264003337 Predicted membrane protein [Function unknown]; Region: COG2119 266264003338 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 266264003339 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 266264003341 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266264003342 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 266264003343 putative di-iron ligands [ion binding]; other site 266264003344 guanine deaminase; Provisional; Region: PRK09228 266264003345 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 266264003346 active site 266264003347 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266264003348 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 266264003349 active site 266264003350 purine riboside binding site [chemical binding]; other site 266264003351 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266264003352 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 266264003353 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266264003354 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 266264003355 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266264003356 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264003357 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 266264003358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266264003359 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266264003360 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 266264003361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264003362 Helix-turn-helix domains; Region: HTH; cl00088 266264003363 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 266264003364 putative substrate binding pocket [chemical binding]; other site 266264003365 putative dimerization interface [polypeptide binding]; other site 266264003366 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 266264003367 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264003368 Helix-turn-helix domains; Region: HTH; cl00088 266264003369 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264003370 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 266264003371 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 266264003372 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 266264003373 apolar tunnel; other site 266264003374 heme binding site [chemical binding]; other site 266264003375 dimerization interface [polypeptide binding]; other site 266264003376 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 266264003377 Helix-turn-helix domains; Region: HTH; cl00088 266264003378 Bacterial transcriptional repressor; Region: TetR; pfam13972 266264003379 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266264003380 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 266264003381 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264003382 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 266264003383 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264003384 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 266264003385 putative active site [active] 266264003386 putative metal binding site [ion binding]; other site 266264003387 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264003388 RDD family; Region: RDD; cl00746 266264003389 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 266264003390 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 266264003391 RNA polymerase factor sigma-70; Validated; Region: PRK09047 266264003392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264003393 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264003394 DNA binding residues [nucleotide binding] 266264003395 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 266264003396 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264003397 PYR/PP interface [polypeptide binding]; other site 266264003398 dimer interface [polypeptide binding]; other site 266264003399 TPP binding site [chemical binding]; other site 266264003400 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266264003401 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 266264003402 TPP-binding site [chemical binding]; other site 266264003403 dimer interface [polypeptide binding]; other site 266264003404 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 266264003405 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 266264003406 putative valine binding site [chemical binding]; other site 266264003407 dimer interface [polypeptide binding]; other site 266264003408 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 266264003409 ketol-acid reductoisomerase; Provisional; Region: PRK05479 266264003410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264003411 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 266264003412 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 266264003413 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266264003414 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 266264003415 BON domain; Region: BON; cl02771 266264003416 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264003417 2-isopropylmalate synthase; Validated; Region: PRK00915 266264003418 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 266264003419 active site 266264003420 catalytic residues [active] 266264003421 metal binding site [ion binding]; metal-binding site 266264003422 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 266264003423 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264003424 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 266264003425 putative ligand binding site [chemical binding]; other site 266264003426 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 266264003427 16S/18S rRNA binding site [nucleotide binding]; other site 266264003428 S13e-L30e interaction site [polypeptide binding]; other site 266264003429 25S rRNA binding site [nucleotide binding]; other site 266264003430 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 266264003431 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 266264003432 RNase E interface [polypeptide binding]; other site 266264003433 trimer interface [polypeptide binding]; other site 266264003434 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 266264003435 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 266264003436 RNase E interface [polypeptide binding]; other site 266264003437 trimer interface [polypeptide binding]; other site 266264003438 active site 266264003439 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 266264003440 putative nucleic acid binding region [nucleotide binding]; other site 266264003441 G-X-X-G motif; other site 266264003442 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 266264003443 RNA binding site [nucleotide binding]; other site 266264003444 domain interface; other site 266264003445 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266264003446 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 266264003447 NAD(P) binding site [chemical binding]; other site 266264003448 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266264003449 substrate binding site [chemical binding]; other site 266264003450 dimer interface [polypeptide binding]; other site 266264003451 catalytic triad [active] 266264003452 Preprotein translocase SecG subunit; Region: SecG; cl09123 266264003453 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 266264003454 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 266264003455 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 266264003456 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 266264003457 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 266264003458 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 266264003459 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 266264003460 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 266264003461 putative dimer interface [polypeptide binding]; other site 266264003462 [2Fe-2S] cluster binding site [ion binding]; other site 266264003463 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 266264003464 SLBB domain; Region: SLBB; pfam10531 266264003465 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 266264003466 NADH dehydrogenase subunit G; Validated; Region: PRK09129 266264003467 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264003468 catalytic loop [active] 266264003469 iron binding site [ion binding]; other site 266264003470 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 266264003471 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 266264003472 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 266264003473 NADH dehydrogenase; Region: NADHdh; cl00469 266264003474 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 266264003475 4Fe-4S binding domain; Region: Fer4; cl02805 266264003476 4Fe-4S binding domain; Region: Fer4; cl02805 266264003477 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 266264003478 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 266264003479 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 266264003480 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 266264003481 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 266264003482 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 266264003483 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 266264003484 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 266264003485 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 266264003486 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 266264003487 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 266264003488 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 266264003489 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 266264003490 dimer interface [polypeptide binding]; other site 266264003491 ADP-ribose binding site [chemical binding]; other site 266264003492 active site 266264003493 nudix motif; other site 266264003494 metal binding site [ion binding]; metal-binding site 266264003495 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 266264003496 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 266264003497 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264003498 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 266264003499 FAD binding site [chemical binding]; other site 266264003500 substrate binding site [chemical binding]; other site 266264003501 catalytic base [active] 266264003502 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264003503 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264003504 active site 266264003505 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266264003506 putative active site [active] 266264003507 putative catalytic site [active] 266264003508 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 266264003509 putative active site [active] 266264003510 putative catalytic site [active] 266264003511 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 266264003512 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264003513 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 266264003514 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266264003515 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266264003516 D-pathway; other site 266264003517 Putative ubiquinol binding site [chemical binding]; other site 266264003518 Low-spin heme (heme b) binding site [chemical binding]; other site 266264003519 Putative water exit pathway; other site 266264003520 Binuclear center (heme o3/CuB) [ion binding]; other site 266264003521 K-pathway; other site 266264003522 Putative proton exit pathway; other site 266264003523 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 266264003524 Subunit I/III interface [polypeptide binding]; other site 266264003525 Subunit III/IV interface [polypeptide binding]; other site 266264003526 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 266264003527 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264003528 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 266264003529 putative ligand binding site [chemical binding]; other site 266264003530 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264003531 TM-ABC transporter signature motif; other site 266264003532 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264003533 TM-ABC transporter signature motif; other site 266264003534 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 266264003535 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264003536 Walker A/P-loop; other site 266264003537 ATP binding site [chemical binding]; other site 266264003538 Q-loop/lid; other site 266264003539 ABC transporter signature motif; other site 266264003540 Walker B; other site 266264003541 D-loop; other site 266264003542 H-loop/switch region; other site 266264003543 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 266264003544 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264003545 Walker A/P-loop; other site 266264003546 ATP binding site [chemical binding]; other site 266264003547 Q-loop/lid; other site 266264003548 ABC transporter signature motif; other site 266264003549 Walker B; other site 266264003550 D-loop; other site 266264003551 H-loop/switch region; other site 266264003552 UreD urease accessory protein; Region: UreD; cl00530 266264003553 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 266264003554 alpha-gamma subunit interface [polypeptide binding]; other site 266264003555 beta-gamma subunit interface [polypeptide binding]; other site 266264003556 HupE / UreJ protein; Region: HupE_UreJ; cl01011 266264003557 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 266264003558 gamma-beta subunit interface [polypeptide binding]; other site 266264003559 alpha-beta subunit interface [polypeptide binding]; other site 266264003560 urease subunit alpha; Reviewed; Region: ureC; PRK13207 266264003561 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 266264003562 subunit interactions [polypeptide binding]; other site 266264003563 active site 266264003564 flap region; other site 266264003565 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 266264003566 dimer interface [polypeptide binding]; other site 266264003567 catalytic residues [active] 266264003568 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 266264003569 UreF; Region: UreF; pfam01730 266264003570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264003571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264003572 non-specific DNA binding site [nucleotide binding]; other site 266264003573 salt bridge; other site 266264003574 sequence-specific DNA binding site [nucleotide binding]; other site 266264003575 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 266264003576 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266264003577 C-terminal domain interface [polypeptide binding]; other site 266264003578 GSH binding site (G-site) [chemical binding]; other site 266264003579 dimer interface [polypeptide binding]; other site 266264003580 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 266264003581 N-terminal domain interface [polypeptide binding]; other site 266264003582 putative dimer interface [polypeptide binding]; other site 266264003583 active site 266264003584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264003585 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 266264003586 FAD binding site [chemical binding]; other site 266264003587 substrate binding site [chemical binding]; other site 266264003588 catalytic base [active] 266264003589 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 266264003590 Helix-turn-helix domains; Region: HTH; cl00088 266264003591 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 266264003592 substrate binding pocket [chemical binding]; other site 266264003593 dimerization interface [polypeptide binding]; other site 266264003594 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 266264003595 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266264003596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264003597 NMT1-like family; Region: NMT1_2; cl15260 266264003598 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 266264003599 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266264003600 putative active site [active] 266264003601 putative substrate binding site [chemical binding]; other site 266264003602 ATP binding site [chemical binding]; other site 266264003603 enoyl-CoA hydratase; Provisional; Region: PRK07511 266264003604 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264003605 substrate binding site [chemical binding]; other site 266264003606 oxyanion hole (OAH) forming residues; other site 266264003607 trimer interface [polypeptide binding]; other site 266264003608 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 266264003609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264003610 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264003611 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264003612 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264003613 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266264003614 C-terminal domain interface [polypeptide binding]; other site 266264003615 GSH binding site (G-site) [chemical binding]; other site 266264003616 dimer interface [polypeptide binding]; other site 266264003617 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 266264003618 putative N-terminal domain interface [polypeptide binding]; other site 266264003619 putative dimer interface [polypeptide binding]; other site 266264003620 putative substrate binding pocket (H-site) [chemical binding]; other site 266264003621 methionine aminotransferase; Validated; Region: PRK09082 266264003622 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264003623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264003624 homodimer interface [polypeptide binding]; other site 266264003625 catalytic residue [active] 266264003626 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 266264003627 Protein of unknown function (DUF328); Region: DUF328; cl01143 266264003628 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 266264003629 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 266264003630 putative active site [active] 266264003631 Zn binding site [ion binding]; other site 266264003632 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266264003633 NMT1-like family; Region: NMT1_2; cl15260 266264003634 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264003635 Helix-turn-helix domains; Region: HTH; cl00088 266264003636 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 266264003637 dimerization interface [polypeptide binding]; other site 266264003638 substrate binding pocket [chemical binding]; other site 266264003639 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266264003640 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266264003641 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264003642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264003643 Walker A motif; other site 266264003644 ATP binding site [chemical binding]; other site 266264003645 Walker B motif; other site 266264003646 arginine finger; other site 266264003647 Cytochrome c; Region: Cytochrom_C; cl11414 266264003648 Cytochrome c; Region: Cytochrom_C; cl11414 266264003649 NeuB family; Region: NeuB; cl00496 266264003650 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266264003651 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266264003652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264003653 S-adenosylmethionine binding site [chemical binding]; other site 266264003654 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 266264003655 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 266264003656 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266264003657 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 266264003658 putative active site [active] 266264003659 catalytic triad [active] 266264003660 dimer interface [polypeptide binding]; other site 266264003661 Predicted membrane protein [Function unknown]; Region: COG3164 266264003662 AsmA-like C-terminal region; Region: AsmA_2; cl15864 266264003663 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 266264003664 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266264003665 metal binding triad; other site 266264003666 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266264003667 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266264003668 metal binding triad; other site 266264003669 Rhomboid family; Region: Rhomboid; cl11446 266264003670 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 266264003671 active site 266264003672 catalytic triad [active] 266264003673 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 266264003674 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 266264003675 Walker A/P-loop; other site 266264003676 ATP binding site [chemical binding]; other site 266264003677 Q-loop/lid; other site 266264003678 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 266264003679 ABC transporter signature motif; other site 266264003680 Walker B; other site 266264003681 D-loop; other site 266264003682 H-loop/switch region; other site 266264003683 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 266264003684 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 266264003685 Helix-turn-helix domains; Region: HTH; cl00088 266264003686 ferrochelatase; Reviewed; Region: hemH; PRK00035 266264003687 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 266264003688 C-terminal domain interface [polypeptide binding]; other site 266264003689 active site 266264003690 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 266264003691 active site 266264003692 N-terminal domain interface [polypeptide binding]; other site 266264003693 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264003694 RNA binding surface [nucleotide binding]; other site 266264003695 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 266264003696 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 266264003697 dimer interface [polypeptide binding]; other site 266264003698 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 266264003699 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266264003700 catalytic residues [active] 266264003701 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 266264003702 dimerization interface [polypeptide binding]; other site 266264003703 substrate binding site [chemical binding]; other site 266264003704 active site 266264003705 calcium binding site [ion binding]; other site 266264003706 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 266264003707 EamA-like transporter family; Region: EamA; cl01037 266264003708 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 266264003709 putative FMN binding site [chemical binding]; other site 266264003710 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 266264003711 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264003712 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264003713 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266264003714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264003715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264003716 Helix-turn-helix domains; Region: HTH; cl00088 266264003717 endonuclease III; Provisional; Region: PRK10702 266264003718 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266264003719 minor groove reading motif; other site 266264003720 helix-hairpin-helix signature motif; other site 266264003721 substrate binding pocket [chemical binding]; other site 266264003722 active site 266264003723 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 266264003724 ferredoxin; Provisional; Region: PRK06991 266264003725 Putative Fe-S cluster; Region: FeS; pfam04060 266264003726 4Fe-4S binding domain; Region: Fer4; cl02805 266264003727 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266264003728 Helix-turn-helix domains; Region: HTH; cl00088 266264003729 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 266264003730 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 266264003731 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 266264003732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264003733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264003734 homodimer interface [polypeptide binding]; other site 266264003735 catalytic residue [active] 266264003736 excinuclease ABC subunit B; Provisional; Region: PRK05298 266264003737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264003738 ATP binding site [chemical binding]; other site 266264003739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264003740 nucleotide binding region [chemical binding]; other site 266264003741 ATP-binding site [chemical binding]; other site 266264003742 Ultra-violet resistance protein B; Region: UvrB; pfam12344 266264003743 UvrB/uvrC motif; Region: UVR; pfam02151 266264003744 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266264003745 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266264003746 active site 266264003747 Site-specific recombinase; Region: SpecificRecomb; cl15411 266264003748 Helix-turn-helix domains; Region: HTH; cl00088 266264003749 Rrf2 family protein; Region: rrf2_super; TIGR00738 266264003750 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264003751 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 266264003752 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264003753 catalytic residue [active] 266264003754 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266264003755 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266264003756 trimerization site [polypeptide binding]; other site 266264003757 active site 266264003758 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266264003759 co-chaperone HscB; Provisional; Region: hscB; PRK03578 266264003760 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 266264003761 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 266264003762 chaperone protein HscA; Provisional; Region: hscA; PRK05183 266264003763 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 266264003764 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264003765 catalytic loop [active] 266264003766 iron binding site [ion binding]; other site 266264003767 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 266264003768 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 266264003769 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 266264003770 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 266264003771 dimer interface [polypeptide binding]; other site 266264003772 putative anticodon binding site; other site 266264003773 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 266264003774 motif 1; other site 266264003775 active site 266264003776 motif 2; other site 266264003777 motif 3; other site 266264003778 short chain dehydrogenase; Provisional; Region: PRK07023 266264003779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264003780 NAD(P) binding site [chemical binding]; other site 266264003781 active site 266264003782 peptide chain release factor 2; Validated; Region: prfB; PRK00578 266264003783 RF-1 domain; Region: RF-1; cl02875 266264003784 RF-1 domain; Region: RF-1; cl02875 266264003785 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264003786 Peptidase family M23; Region: Peptidase_M23; pfam01551 266264003787 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 266264003788 DHH family; Region: DHH; pfam01368 266264003789 DHHA1 domain; Region: DHHA1; pfam02272 266264003790 Sulfatase; Region: Sulfatase; cl10460 266264003791 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 266264003792 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266264003793 FtsX-like permease family; Region: FtsX; cl15850 266264003794 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 266264003795 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266264003796 Walker A/P-loop; other site 266264003797 ATP binding site [chemical binding]; other site 266264003798 Q-loop/lid; other site 266264003799 ABC transporter signature motif; other site 266264003800 Walker B; other site 266264003801 D-loop; other site 266264003802 H-loop/switch region; other site 266264003803 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266264003804 active site 266264003805 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 266264003806 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 266264003807 Competence protein; Region: Competence; cl00471 266264003808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264003809 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 266264003810 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266264003811 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266264003812 putative active site [active] 266264003813 6-phosphogluconate dehydratase; Region: edd; TIGR01196 266264003814 Dehydratase family; Region: ILVD_EDD; cl00340 266264003815 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 266264003816 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 266264003817 ATP-binding site [chemical binding]; other site 266264003818 Gluconate-6-phosphate binding site [chemical binding]; other site 266264003819 Uncharacterized conserved protein [Function unknown]; Region: COG2308 266264003820 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 266264003821 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 266264003822 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266264003823 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266264003824 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266264003825 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 266264003826 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 266264003827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264003828 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 266264003829 nucleophilic elbow; other site 266264003830 catalytic triad; other site 266264003831 CTP synthetase; Validated; Region: pyrG; PRK05380 266264003832 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 266264003833 Catalytic site [active] 266264003834 active site 266264003835 UTP binding site [chemical binding]; other site 266264003836 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 266264003837 active site 266264003838 putative oxyanion hole; other site 266264003839 catalytic triad [active] 266264003840 NeuB family; Region: NeuB; cl00496 266264003841 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266264003842 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 266264003843 enolase; Provisional; Region: eno; PRK00077 266264003844 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 266264003845 dimer interface [polypeptide binding]; other site 266264003846 metal binding site [ion binding]; metal-binding site 266264003847 substrate binding pocket [chemical binding]; other site 266264003848 Septum formation initiator; Region: DivIC; cl11433 266264003849 Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281 266264003850 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 266264003851 dimerization interface [polypeptide binding]; other site 266264003852 domain crossover interface; other site 266264003853 redox-dependent activation switch; other site 266264003854 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266264003855 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 266264003856 trimer interface [polypeptide binding]; other site 266264003857 putative metal binding site [ion binding]; other site 266264003858 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266264003859 dinuclear metal binding motif [ion binding]; other site 266264003860 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266264003861 AMP-binding enzyme; Region: AMP-binding; cl15778 266264003862 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264003863 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 266264003864 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264003865 nucleophilic elbow; other site 266264003866 catalytic triad; other site 266264003867 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 266264003868 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266264003869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264003870 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 266264003871 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 266264003872 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 266264003873 active site 266264003874 putative substrate binding region [chemical binding]; other site 266264003875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264003876 S-adenosylmethionine binding site [chemical binding]; other site 266264003877 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266264003878 dihydrodipicolinate synthase; Region: dapA; TIGR00674 266264003879 dimer interface [polypeptide binding]; other site 266264003880 active site 266264003881 catalytic residue [active] 266264003882 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 266264003883 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 266264003884 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264003885 Uncharacterized conserved protein [Function unknown]; Region: COG2850 266264003886 JmjC domain, hydroxylase; Region: JmjC; cl15814 266264003887 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 266264003888 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 266264003889 MutS domain I; Region: MutS_I; pfam01624 266264003890 MutS domain II; Region: MutS_II; pfam05188 266264003891 MutS family domain IV; Region: MutS_IV; pfam05190 266264003892 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 266264003893 Walker A/P-loop; other site 266264003894 ATP binding site [chemical binding]; other site 266264003895 Q-loop/lid; other site 266264003896 ABC transporter signature motif; other site 266264003897 Walker B; other site 266264003898 D-loop; other site 266264003899 H-loop/switch region; other site 266264003900 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 266264003901 YcfA-like protein; Region: YcfA; cl00752 266264003902 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 266264003903 active site 266264003904 dimerization interface [polypeptide binding]; other site 266264003905 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 266264003906 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 266264003907 serine O-acetyltransferase; Region: cysE; TIGR01172 266264003908 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266264003909 trimer interface [polypeptide binding]; other site 266264003910 active site 266264003911 substrate binding site [chemical binding]; other site 266264003912 CoA binding site [chemical binding]; other site 266264003913 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 266264003914 putative active site [active] 266264003915 putative metal binding site [ion binding]; other site 266264003916 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 266264003917 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 266264003918 substrate binding site [chemical binding]; other site 266264003919 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 266264003920 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 266264003921 active site 266264003922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264003923 TPR motif; other site 266264003924 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266264003925 binding surface 266264003926 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 266264003927 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266264003928 active site 266264003929 HIGH motif; other site 266264003930 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266264003931 KMSKS motif; other site 266264003932 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 266264003933 tRNA binding surface [nucleotide binding]; other site 266264003934 anticodon binding site; other site 266264003935 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266264003936 endonuclease III; Region: ENDO3c; smart00478 266264003937 minor groove reading motif; other site 266264003938 helix-hairpin-helix signature motif; other site 266264003939 substrate binding pocket [chemical binding]; other site 266264003940 active site 266264003941 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266264003942 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 266264003943 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 266264003944 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 266264003945 Ligand Binding Site [chemical binding]; other site 266264003946 TilS substrate binding domain; Region: TilS; pfam09179 266264003947 B3/4 domain; Region: B3_4; cl11458 266264003948 aspartate kinase; Reviewed; Region: PRK06635 266264003949 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 266264003950 putative nucleotide binding site [chemical binding]; other site 266264003951 putative catalytic residues [active] 266264003952 putative Mg ion binding site [ion binding]; other site 266264003953 putative aspartate binding site [chemical binding]; other site 266264003954 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 266264003955 putative allosteric regulatory site; other site 266264003956 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 266264003957 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 266264003958 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 266264003959 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264003960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264003961 metal binding site [ion binding]; metal-binding site 266264003962 active site 266264003963 I-site; other site 266264003964 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266264003965 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266264003966 transmembrane helices; other site 266264003967 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266264003968 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 266264003969 NAD binding site [chemical binding]; other site 266264003970 substrate binding site [chemical binding]; other site 266264003971 catalytic Zn binding site [ion binding]; other site 266264003972 tetramer interface [polypeptide binding]; other site 266264003973 structural Zn binding site [ion binding]; other site 266264003974 Surface antigen; Region: Bac_surface_Ag; cl03097 266264003975 Surface antigen; Region: Bac_surface_Ag; cl03097 266264003976 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266264003977 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264003978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264003979 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 266264003980 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 266264003981 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 266264003982 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266264003983 active site 266264003984 HIGH motif; other site 266264003985 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266264003986 KMSKS motif; other site 266264003987 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266264003988 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266264003989 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266264003990 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 266264003991 trimer interface [polypeptide binding]; other site 266264003992 active site 266264003993 dihydroorotase; Validated; Region: PRK09060 266264003994 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264003995 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 266264003996 active site 266264003997 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264003998 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264003999 N-terminal plug; other site 266264004000 ligand-binding site [chemical binding]; other site 266264004001 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 266264004002 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 266264004003 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 266264004004 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264004005 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264004006 N-terminal plug; other site 266264004007 ligand-binding site [chemical binding]; other site 266264004008 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 266264004009 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 266264004010 active site 266264004011 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264004012 dimer interface [polypeptide binding]; other site 266264004013 catalytic residues [active] 266264004014 substrate binding site [chemical binding]; other site 266264004015 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 266264004016 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266264004017 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 266264004018 IucA / IucC family; Region: IucA_IucC; pfam04183 266264004019 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 266264004020 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 266264004021 IucA / IucC family; Region: IucA_IucC; pfam04183 266264004022 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 266264004023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264004024 putative substrate translocation pore; other site 266264004025 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 266264004026 IucA / IucC family; Region: IucA_IucC; pfam04183 266264004027 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 266264004028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264004029 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 266264004030 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 266264004031 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266264004032 dimer interface [polypeptide binding]; other site 266264004033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264004034 catalytic residue [active] 266264004035 Secretin and TonB N terminus short domain; Region: STN; cl06624 266264004036 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264004037 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264004038 N-terminal plug; other site 266264004039 ligand-binding site [chemical binding]; other site 266264004040 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 266264004041 FecR protein; Region: FecR; pfam04773 266264004042 RNA polymerase sigma factor; Reviewed; Region: PRK12527 266264004043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264004044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264004045 DNA binding residues [nucleotide binding] 266264004046 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266264004047 Protein export membrane protein; Region: SecD_SecF; cl14618 266264004048 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266264004049 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 266264004050 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264004051 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264004052 substrate binding pocket [chemical binding]; other site 266264004053 membrane-bound complex binding site; other site 266264004054 hinge residues; other site 266264004055 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 266264004056 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 266264004057 putative molybdopterin cofactor binding site [chemical binding]; other site 266264004058 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 266264004059 putative molybdopterin cofactor binding site; other site 266264004060 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 266264004061 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264004062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264004063 DNA-binding site [nucleotide binding]; DNA binding site 266264004064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264004065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264004066 homodimer interface [polypeptide binding]; other site 266264004067 catalytic residue [active] 266264004068 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264004069 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264004070 FAD binding domain; Region: FAD_binding_4; pfam01565 266264004071 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 266264004072 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264004073 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 266264004074 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 266264004075 Protein of unknown function (DUF962); Region: DUF962; cl01879 266264004076 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264004077 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264004078 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 266264004079 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266264004080 homodimer interface [polypeptide binding]; other site 266264004081 substrate-cofactor binding pocket; other site 266264004082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264004083 catalytic residue [active] 266264004084 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 266264004085 FOG: CBS domain [General function prediction only]; Region: COG0517 266264004086 lysophospholipid transporter LplT; Provisional; Region: PRK11195 266264004087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264004088 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266264004089 putative acyl-acceptor binding pocket; other site 266264004090 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 266264004091 putative C-terminal domain interface [polypeptide binding]; other site 266264004092 putative GSH binding site [chemical binding]; other site 266264004093 putative dimer interface [polypeptide binding]; other site 266264004094 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 266264004095 putative N-terminal domain interface [polypeptide binding]; other site 266264004096 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 266264004097 Tetramer interface [polypeptide binding]; other site 266264004098 active site 266264004099 FMN-binding site [chemical binding]; other site 266264004100 MFS_1 like family; Region: MFS_1_like; pfam12832 266264004101 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 266264004102 Predicted dehydrogenase [General function prediction only]; Region: COG0579 266264004103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264004104 DNA-binding site [nucleotide binding]; DNA binding site 266264004105 FCD domain; Region: FCD; cl11656 266264004106 Flagellar protein YcgR; Region: YcgR_2; pfam12945 266264004107 PilZ domain; Region: PilZ; cl01260 266264004108 Cytochrome c; Region: Cytochrom_C; cl11414 266264004109 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264004110 Cytochrome c; Region: Cytochrom_C; cl11414 266264004111 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 266264004112 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 266264004113 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 266264004114 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 266264004115 molybdopterin cofactor binding site [chemical binding]; other site 266264004116 substrate binding site [chemical binding]; other site 266264004117 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 266264004118 molybdopterin cofactor binding site; other site 266264004119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264004120 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266264004121 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 266264004122 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 266264004123 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264004124 classical (c) SDRs; Region: SDR_c; cd05233 266264004125 NAD(P) binding site [chemical binding]; other site 266264004126 active site 266264004127 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 266264004128 DctM-like transporters; Region: DctM; pfam06808 266264004129 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 266264004130 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266264004131 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266264004132 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264004133 active site 266264004134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264004135 PAS domain; Region: PAS_9; pfam13426 266264004136 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264004137 DNA binding residues [nucleotide binding] 266264004138 dimerization interface [polypeptide binding]; other site 266264004139 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264004140 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264004141 Protein of unknown function, DUF; Region: DUF411; cl01142 266264004142 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 266264004143 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 266264004144 NAD binding site [chemical binding]; other site 266264004145 homotetramer interface [polypeptide binding]; other site 266264004146 homodimer interface [polypeptide binding]; other site 266264004147 substrate binding site [chemical binding]; other site 266264004148 active site 266264004149 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264004150 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264004151 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266264004152 homotrimer interaction site [polypeptide binding]; other site 266264004153 putative active site [active] 266264004154 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266264004155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266264004156 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266264004157 synthetase active site [active] 266264004158 NTP binding site [chemical binding]; other site 266264004159 metal binding site [ion binding]; metal-binding site 266264004160 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266264004161 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266264004162 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 266264004163 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 266264004164 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 266264004165 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 266264004166 active site 266264004167 dimer interface [polypeptide binding]; other site 266264004168 motif 1; other site 266264004169 motif 2; other site 266264004170 motif 3; other site 266264004171 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 266264004172 anticodon binding site; other site 266264004173 translation initiation factor IF-3; Region: infC; TIGR00168 266264004174 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 266264004175 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 266264004176 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 266264004177 ribosomal protein L20; Region: rpl20; CHL00068 266264004178 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 266264004179 23S rRNA binding site [nucleotide binding]; other site 266264004180 L21 binding site [polypeptide binding]; other site 266264004181 L13 binding site [polypeptide binding]; other site 266264004182 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 266264004183 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 266264004184 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 266264004185 dimer interface [polypeptide binding]; other site 266264004186 motif 1; other site 266264004187 active site 266264004188 motif 2; other site 266264004189 motif 3; other site 266264004190 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 266264004191 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 266264004192 putative tRNA-binding site [nucleotide binding]; other site 266264004193 B3/4 domain; Region: B3_4; cl11458 266264004194 tRNA synthetase B5 domain; Region: B5; cl08394 266264004195 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 266264004196 dimer interface [polypeptide binding]; other site 266264004197 motif 1; other site 266264004198 motif 3; other site 266264004199 motif 2; other site 266264004200 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 266264004201 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266264004202 IHF - DNA interface [nucleotide binding]; other site 266264004203 IHF dimer interface [polypeptide binding]; other site 266264004204 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 266264004205 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266264004206 DNA binding residues [nucleotide binding] 266264004207 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 266264004208 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 266264004209 putative trimer interface [polypeptide binding]; other site 266264004210 putative CoA binding site [chemical binding]; other site 266264004211 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 266264004212 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266264004213 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 266264004214 catalytic residues [active] 266264004215 Transposase domain (DUF772); Region: DUF772; pfam05598 266264004216 DDE superfamily endonuclease; Region: DDE_4; cl15789 266264004217 Protein-methionine-S-oxide reductase 266264004218 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264004219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264004220 active site 266264004221 phosphorylation site [posttranslational modification] 266264004222 intermolecular recognition site; other site 266264004223 dimerization interface [polypeptide binding]; other site 266264004224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264004225 DNA binding site [nucleotide binding] 266264004226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264004227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264004228 dimer interface [polypeptide binding]; other site 266264004229 phosphorylation site [posttranslational modification] 266264004230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264004231 ATP binding site [chemical binding]; other site 266264004232 Mg2+ binding site [ion binding]; other site 266264004233 G-X-G motif; other site 266264004234 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 266264004235 Helix-turn-helix domains; Region: HTH; cl00088 266264004236 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264004237 dimerization interface [polypeptide binding]; other site 266264004238 enolase; Provisional; Region: eno; PRK00077 266264004239 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 266264004240 dimer interface [polypeptide binding]; other site 266264004241 metal binding site [ion binding]; metal-binding site 266264004242 substrate binding pocket [chemical binding]; other site 266264004243 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 266264004244 hypothetical protein 266264004245 hypothetical protein 266264004246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264004247 NMT1-like family; Region: NMT1_2; cl15260 266264004248 Helix-turn-helix domains; Region: HTH; cl00088 266264004249 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266264004250 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264004251 dimerization interface [polypeptide binding]; other site 266264004252 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 266264004253 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 266264004254 active site 266264004255 putative substrate binding pocket [chemical binding]; other site 266264004256 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266264004257 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264004258 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264004259 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264004260 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264004261 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266264004262 putative catalytic site [active] 266264004263 putative phosphate binding site [ion binding]; other site 266264004264 active site 266264004265 metal binding site A [ion binding]; metal-binding site 266264004266 DNA binding site [nucleotide binding] 266264004267 putative AP binding site [nucleotide binding]; other site 266264004268 putative metal binding site B [ion binding]; other site 266264004269 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 266264004270 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 266264004271 active site 266264004272 Zn binding site [ion binding]; other site 266264004273 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 266264004274 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266264004275 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266264004276 homodimer interface [polypeptide binding]; other site 266264004277 NADP binding site [chemical binding]; other site 266264004278 substrate binding site [chemical binding]; other site 266264004279 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 266264004280 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266264004281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264004282 active site 266264004283 phosphorylation site [posttranslational modification] 266264004284 intermolecular recognition site; other site 266264004285 dimerization interface [polypeptide binding]; other site 266264004286 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264004287 DNA binding residues [nucleotide binding] 266264004288 dimerization interface [polypeptide binding]; other site 266264004289 PAS domain S-box; Region: sensory_box; TIGR00229 266264004290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264004291 putative active site [active] 266264004292 heme pocket [chemical binding]; other site 266264004293 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 266264004294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264004295 dimer interface [polypeptide binding]; other site 266264004296 phosphorylation site [posttranslational modification] 266264004297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264004298 ATP binding site [chemical binding]; other site 266264004299 Mg2+ binding site [ion binding]; other site 266264004300 G-X-G motif; other site 266264004301 hypothetical protein 266264004302 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 266264004303 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 266264004304 dimer interface [polypeptide binding]; other site 266264004305 TPP-binding site [chemical binding]; other site 266264004306 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 266264004307 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 266264004308 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264004309 E3 interaction surface; other site 266264004310 lipoyl attachment site [posttranslational modification]; other site 266264004311 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264004312 E3 interaction surface; other site 266264004313 lipoyl attachment site [posttranslational modification]; other site 266264004314 e3 binding domain; Region: E3_binding; pfam02817 266264004315 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 266264004316 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 266264004317 active site 266264004318 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264004319 E3 interaction surface; other site 266264004320 lipoyl attachment site [posttranslational modification]; other site 266264004321 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 266264004322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264004323 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264004324 Phasin protein; Region: Phasin_2; cl11491 266264004325 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 266264004326 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264004327 active site 266264004328 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 266264004329 putative FMN binding site [chemical binding]; other site 266264004330 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 266264004331 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264004332 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264004333 Helix-turn-helix domains; Region: HTH; cl00088 266264004334 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264004335 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 266264004336 Cysteine-rich domain; Region: CCG; pfam02754 266264004337 Cysteine-rich domain; Region: CCG; pfam02754 266264004338 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 266264004339 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 266264004340 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266264004341 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 266264004342 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 266264004343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264004344 Walker A/P-loop; other site 266264004345 ATP binding site [chemical binding]; other site 266264004346 Q-loop/lid; other site 266264004347 ABC transporter signature motif; other site 266264004348 Walker B; other site 266264004349 D-loop; other site 266264004350 H-loop/switch region; other site 266264004351 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 266264004352 TM-ABC transporter signature motif; other site 266264004353 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 266264004354 zinc binding site [ion binding]; other site 266264004355 putative ligand binding site [chemical binding]; other site 266264004356 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266264004357 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264004358 active site 266264004359 catalytic tetrad [active] 266264004360 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 266264004361 quinone interaction residues [chemical binding]; other site 266264004362 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 266264004363 active site 266264004364 catalytic residues [active] 266264004365 FMN binding site [chemical binding]; other site 266264004366 substrate binding site [chemical binding]; other site 266264004367 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 266264004368 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 266264004369 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264004370 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264004371 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 266264004372 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 266264004373 nudix motif; other site 266264004374 RES domain; Region: RES; cl02411 266264004375 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 266264004376 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266264004377 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 266264004378 4Fe-4S binding domain; Region: Fer4; cl02805 266264004379 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 266264004380 dimerization interface [polypeptide binding]; other site 266264004381 FAD binding pocket [chemical binding]; other site 266264004382 FAD binding motif [chemical binding]; other site 266264004383 catalytic residues [active] 266264004384 NAD binding pocket [chemical binding]; other site 266264004385 phosphate binding motif [ion binding]; other site 266264004386 beta-alpha-beta structure motif; other site 266264004387 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 266264004388 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 266264004389 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264004390 substrate binding site [chemical binding]; other site 266264004391 oxyanion hole (OAH) forming residues; other site 266264004392 trimer interface [polypeptide binding]; other site 266264004393 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266264004394 substrate binding site [chemical binding]; other site 266264004395 oxyanion hole (OAH) forming residues; other site 266264004396 trimer interface [polypeptide binding]; other site 266264004397 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 266264004398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264004399 non-specific DNA binding site [nucleotide binding]; other site 266264004400 salt bridge; other site 266264004401 sequence-specific DNA binding site [nucleotide binding]; other site 266264004402 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266264004403 ADP binding site [chemical binding]; other site 266264004404 magnesium binding site [ion binding]; other site 266264004405 putative shikimate binding site; other site 266264004406 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 266264004407 AMP-binding enzyme; Region: AMP-binding; cl15778 266264004408 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264004409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264004410 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264004411 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 266264004412 putative ligand binding site [chemical binding]; other site 266264004413 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264004414 TM-ABC transporter signature motif; other site 266264004415 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264004416 TM-ABC transporter signature motif; other site 266264004417 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264004418 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264004419 Walker A/P-loop; other site 266264004420 ATP binding site [chemical binding]; other site 266264004421 Q-loop/lid; other site 266264004422 ABC transporter signature motif; other site 266264004423 Walker B; other site 266264004424 D-loop; other site 266264004425 H-loop/switch region; other site 266264004426 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264004427 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264004428 Walker A/P-loop; other site 266264004429 ATP binding site [chemical binding]; other site 266264004430 Q-loop/lid; other site 266264004431 ABC transporter signature motif; other site 266264004432 Walker B; other site 266264004433 D-loop; other site 266264004434 H-loop/switch region; other site 266264004435 K+ potassium transporter; Region: K_trans; cl15781 266264004436 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 266264004437 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 266264004438 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 266264004439 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 266264004440 RNA binding site [nucleotide binding]; other site 266264004441 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 266264004442 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264004443 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264004444 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264004445 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266264004446 active site 266264004447 Int/Topo IB signature motif; other site 266264004448 DNA binding site [nucleotide binding] 266264004449 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 266264004450 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 266264004451 DNA repair protein RadC (part 1) 266264004452 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266264004453 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264004454 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266264004455 Int/Topo IB signature motif; other site 266264004456 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 266264004457 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264004458 active site 266264004459 DNA binding site [nucleotide binding] 266264004460 Int/Topo IB signature motif; other site 266264004461 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266264004462 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266264004463 Int/Topo IB signature motif; other site 266264004464 DNA repair protein(fragment; part 2) 266264004465 Domain of unknown function (DUF932); Region: DUF932; cl12129 266264004466 ParB-like nuclease domain; Region: ParBc; cl02129 266264004467 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 266264004468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264004469 Coenzyme A binding pocket [chemical binding]; other site 266264004470 hypothetical protein 266264004471 Protein of unknown function (DUF736); Region: DUF736; cl02303 266264004472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264004473 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266264004474 Winged helix-turn helix; Region: HTH_29; pfam13551 266264004475 Integrase core domain; Region: rve; cl01316 266264004476 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266264004477 Integrase core domain; Region: rve_3; cl15866 266264004478 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 266264004479 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264004480 Replication initiator protein A; Region: RPA; cl02339 266264004481 ParA-like protein; Provisional; Region: PHA02518 266264004482 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264004483 P-loop; other site 266264004484 Magnesium ion binding site [ion binding]; other site 266264004485 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266264004486 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 266264004487 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266264004488 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 266264004489 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266264004490 Cytochrome C'; Region: Cytochrom_C_2; cl01610 266264004491 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 266264004492 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266264004493 MULE transposase domain; Region: MULE; pfam10551 266264004494 transposase/IS protein; Provisional; Region: PRK09183 266264004495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264004496 Walker A motif; other site 266264004497 ATP binding site [chemical binding]; other site 266264004498 Walker B motif; other site 266264004499 arginine finger; other site 266264004500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266264004501 Helix-turn-helix domains; Region: HTH; cl00088 266264004502 Integrase core domain; Region: rve; cl01316 266264004503 Integrase core domain; Region: rve_3; cl15866 266264004504 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266264004505 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 266264004506 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264004507 Beta-Casp domain; Region: Beta-Casp; cl12567 266264004508 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266264004509 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 266264004510 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264004511 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266264004512 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266264004513 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266264004514 transposase (fragment) 266264004515 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264004516 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266264004517 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266264004518 Int/Topo IB signature motif; other site 266264004519 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266264004520 Int/Topo IB signature motif; other site 266264004521 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266264004522 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264004523 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264004524 active site 266264004525 DNA binding site [nucleotide binding] 266264004526 Int/Topo IB signature motif; other site 266264004527 transposase (fragment)IS66 family 266264004528 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 266264004529 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264004530 Walker B; other site 266264004531 D-loop; other site 266264004532 H-loop/switch region; other site 266264004533 transposase (fragment), with second part being Rmet_1304 266264004534 transposase, fragment of tnpB (Rmet_1302) 266264004535 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264004536 Integrase core domain; Region: rve; cl01316 266264004537 Integrase core domain; Region: rve_3; cl15866 266264004538 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 266264004539 dimerization interface [polypeptide binding]; other site 266264004540 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 266264004541 ATP binding site [chemical binding]; other site 266264004542 Hydrogenase formation hypA family; Region: HypD; cl12072 266264004543 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 266264004544 HupF/HypC family; Region: HupF_HypC; cl00394 266264004545 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 266264004546 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264004547 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 266264004548 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 266264004549 Protein of unknown function (DUF3457); Region: DUF3457; cl08122 266264004550 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266264004551 Rubredoxin; Region: Rubredoxin; pfam00301 266264004552 iron binding site [ion binding]; other site 266264004553 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 266264004554 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 266264004555 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 266264004556 HupF/HypC family; Region: HupF_HypC; cl00394 266264004557 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 266264004558 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 266264004559 putative substrate-binding site; other site 266264004560 nickel binding site [ion binding]; other site 266264004561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264004562 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266264004563 HupE / UreJ protein; Region: HupE_UreJ; cl01011 266264004564 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 266264004565 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 266264004566 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 266264004567 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 266264004568 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264004569 Winged helix-turn helix; Region: HTH_29; pfam13551 266264004570 Integrase core domain; Region: rve; cl01316 266264004571 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266264004572 Integrase core domain; Region: rve_3; cl15866 266264004573 IS3/IS407 family, partial tnpB, with second part being Rmet_1279 ((belongs to CMGI-2) 266264004574 Helix-turn-helix domains; Region: HTH; cl00088 266264004575 putative insertion sequence transposase protein IS5 family, partial with second part being Rmet_1278 (belongs to CMGI-2) 266264004576 Activator of aromatic catabolism; Region: XylR_N; pfam06505 266264004577 Heme NO binding; Region: HNOB; cl15268 266264004578 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264004579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264004580 Walker A motif; other site 266264004581 ATP binding site [chemical binding]; other site 266264004582 Walker B motif; other site 266264004583 arginine finger; other site 266264004584 Helix-turn-helix domains; Region: HTH; cl00088 266264004585 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 266264004586 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264004587 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 266264004588 Formaldehyde dehydrogenases; Region: FDH_like; cd05278 266264004589 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266264004590 catalytic Zn binding site [ion binding]; other site 266264004591 NAD(P) binding site [chemical binding]; other site 266264004592 structural Zn binding site [ion binding]; other site 266264004593 DDE superfamily endonuclease; Region: DDE_4; cl15789 266264004594 DDE superfamily endonuclease; Region: DDE_4; cl15789 266264004595 glutathionine S-transferase (fragment) 266264004596 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266264004597 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264004598 catalytic loop [active] 266264004599 iron binding site [ion binding]; other site 266264004600 Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190 266264004601 FAD binding pocket [chemical binding]; other site 266264004602 FAD binding motif [chemical binding]; other site 266264004603 phosphate binding motif [ion binding]; other site 266264004604 beta-alpha-beta structure motif; other site 266264004605 NAD binding pocket [chemical binding]; other site 266264004606 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 266264004607 dimerization interface [polypeptide binding]; other site 266264004608 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 266264004609 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 266264004610 [2Fe-2S] cluster binding site [ion binding]; other site 266264004611 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 266264004612 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 266264004613 dimerization interface [polypeptide binding]; other site 266264004614 putative path to active site cavity [active] 266264004615 diiron center [ion binding]; other site 266264004616 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 266264004617 active site 1 [active] 266264004618 dimer interface [polypeptide binding]; other site 266264004619 hexamer interface [polypeptide binding]; other site 266264004620 active site 2 [active] 266264004621 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264004622 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 266264004623 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 266264004624 active site 266264004625 catalytic residues [active] 266264004626 metal binding site [ion binding]; metal-binding site 266264004627 DmpG-like communication domain; Region: DmpG_comm; pfam07836 266264004628 acetaldehyde dehydrogenase; Validated; Region: PRK08300 266264004629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264004630 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 266264004631 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264004632 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264004633 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 266264004634 NAD binding site [chemical binding]; other site 266264004635 catalytic residues [active] 266264004636 Domain of unknown function (DUF336); Region: DUF336; cl01249 266264004637 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 266264004638 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 266264004639 tetramer interface [polypeptide binding]; other site 266264004640 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 266264004641 tetramer interface [polypeptide binding]; other site 266264004642 active site 266264004643 Fe binding site [ion binding]; other site 266264004644 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264004645 catalytic loop [active] 266264004646 iron binding site [ion binding]; other site 266264004647 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266264004648 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264004649 catalytic loop [active] 266264004650 iron binding site [ion binding]; other site 266264004651 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 266264004652 FAD binding pocket [chemical binding]; other site 266264004653 FAD binding motif [chemical binding]; other site 266264004654 phosphate binding motif [ion binding]; other site 266264004655 beta-alpha-beta structure motif; other site 266264004656 NAD binding pocket [chemical binding]; other site 266264004657 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 266264004658 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 266264004659 dimerization interface [polypeptide binding]; other site 266264004660 putative path to active site cavity [active] 266264004661 diiron center [ion binding]; other site 266264004662 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 266264004663 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 266264004664 dimerization interface [polypeptide binding]; other site 266264004665 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 266264004666 conserved hypothetical protein (partial)(gene belongs to CMGI-2) 266264004667 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 266264004668 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266264004669 NAD(P) binding site [chemical binding]; other site 266264004670 homotetramer interface [polypeptide binding]; other site 266264004671 homodimer interface [polypeptide binding]; other site 266264004672 active site 266264004673 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264004674 Ligand Binding Site [chemical binding]; other site 266264004675 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266264004676 classical (c) SDRs; Region: SDR_c; cd05233 266264004677 NAD(P) binding site [chemical binding]; other site 266264004678 active site 266264004679 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264004680 Helix-turn-helix domains; Region: HTH; cl00088 266264004681 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264004682 dimerization interface [polypeptide binding]; other site 266264004683 substrate binding pocket [chemical binding]; other site 266264004684 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266264004685 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264004686 Walker A motif; other site 266264004687 ATP binding site [chemical binding]; other site 266264004688 Walker B motif; other site 266264004689 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 266264004690 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 266264004691 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266264004692 ATP binding site [chemical binding]; other site 266264004693 Walker A motif; other site 266264004694 hexamer interface [polypeptide binding]; other site 266264004695 Walker B motif; other site 266264004696 TrbC/VIRB2 family; Region: TrbC; cl01583 266264004697 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266264004698 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266264004699 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266264004700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264004701 Walker A motif; other site 266264004702 ATP binding site [chemical binding]; other site 266264004703 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 266264004704 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 266264004705 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266264004706 VirB8 protein; Region: VirB8; cl01500 266264004707 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266264004708 VirB7 interaction site; other site 266264004709 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 266264004710 Protein of unknown function (DUF2274); Region: DUF2274; cl02406 266264004711 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 266264004712 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 266264004713 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264004714 RNA binding surface [nucleotide binding]; other site 266264004715 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266264004716 active site 266264004717 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 266264004718 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 266264004719 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266264004720 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266264004721 putative acyltransferase; Provisional; Region: PRK05790 266264004722 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264004723 dimer interface [polypeptide binding]; other site 266264004724 active site 266264004725 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 266264004726 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266264004727 NAD(P) binding site [chemical binding]; other site 266264004728 homotetramer interface [polypeptide binding]; other site 266264004729 homodimer interface [polypeptide binding]; other site 266264004730 active site 266264004731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 266264004732 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 266264004733 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 266264004734 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 266264004735 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 266264004736 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266264004737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264004738 FeS/SAM binding site; other site 266264004739 TRAM domain; Region: TRAM; cl01282 266264004740 beta-ketothiolase; Provisional; Region: PRK09051 266264004741 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264004742 dimer interface [polypeptide binding]; other site 266264004743 active site 266264004744 cystathionine beta-lyase; Provisional; Region: PRK07050 266264004745 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264004746 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264004747 catalytic residue [active] 266264004748 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 266264004749 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 266264004750 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 266264004751 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 266264004752 phosphoserine phosphatase SerB; Region: serB; TIGR00338 266264004753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264004754 motif II; other site 266264004755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264004756 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266264004757 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266264004758 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264004759 substrate binding pocket [chemical binding]; other site 266264004760 membrane-bound complex binding site; other site 266264004761 hinge residues; other site 266264004762 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 266264004763 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266264004764 active site 266264004765 dimer interface [polypeptide binding]; other site 266264004766 non-prolyl cis peptide bond; other site 266264004767 insertion regions; other site 266264004768 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264004769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264004770 putative PBP binding loops; other site 266264004771 dimer interface [polypeptide binding]; other site 266264004772 ABC-ATPase subunit interface; other site 266264004773 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 266264004774 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266264004775 Walker A/P-loop; other site 266264004776 ATP binding site [chemical binding]; other site 266264004777 Q-loop/lid; other site 266264004778 ABC transporter signature motif; other site 266264004779 Walker B; other site 266264004780 D-loop; other site 266264004781 H-loop/switch region; other site 266264004782 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 266264004783 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264004784 sulfate transport protein; Provisional; Region: cysT; CHL00187 266264004785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264004786 dimer interface [polypeptide binding]; other site 266264004787 conserved gate region; other site 266264004788 putative PBP binding loops; other site 266264004789 ABC-ATPase subunit interface; other site 266264004790 sulfate transport protein; Provisional; Region: cysT; CHL00187 266264004791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264004792 dimer interface [polypeptide binding]; other site 266264004793 conserved gate region; other site 266264004794 putative PBP binding loops; other site 266264004795 ABC-ATPase subunit interface; other site 266264004796 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 266264004797 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 266264004798 Walker A/P-loop; other site 266264004799 ATP binding site [chemical binding]; other site 266264004800 Q-loop/lid; other site 266264004801 ABC transporter signature motif; other site 266264004802 Walker B; other site 266264004803 D-loop; other site 266264004804 H-loop/switch region; other site 266264004805 TOBE-like domain; Region: TOBE_3; pfam12857 266264004806 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 266264004807 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 266264004808 substrate binding site [chemical binding]; other site 266264004809 dimerization interface [polypeptide binding]; other site 266264004810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266264004811 Histidine kinase; Region: His_kinase; pfam06580 266264004812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 266264004813 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 266264004814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264004815 active site 266264004816 phosphorylation site [posttranslational modification] 266264004817 intermolecular recognition site; other site 266264004818 dimerization interface [polypeptide binding]; other site 266264004819 LytTr DNA-binding domain; Region: LytTR; cl04498 266264004820 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 266264004821 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266264004822 putative active site pocket [active] 266264004823 dimerization interface [polypeptide binding]; other site 266264004824 putative catalytic residue [active] 266264004825 short chain dehydrogenase; Validated; Region: PRK05855 266264004826 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264004827 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 266264004828 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266264004829 tetramer interface [polypeptide binding]; other site 266264004830 active site 266264004831 Mg2+/Mn2+ binding site [ion binding]; other site 266264004832 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 266264004833 Putative glucoamylase; Region: Glycoamylase; pfam10091 266264004834 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264004835 Ligand Binding Site [chemical binding]; other site 266264004836 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 266264004837 Helix-turn-helix domains; Region: HTH; cl00088 266264004838 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264004839 putative effector binding pocket; other site 266264004840 dimerization interface [polypeptide binding]; other site 266264004841 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266264004842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264004843 motif II; other site 266264004844 malate synthase A; Region: malate_syn_A; TIGR01344 266264004845 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 266264004846 active site 266264004847 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266264004848 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264004849 active site 266264004850 metal binding site [ion binding]; metal-binding site 266264004851 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 266264004852 putative hydrophobic ligand binding site [chemical binding]; other site 266264004853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264004854 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264004855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264004856 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 266264004857 acyl-CoA binding pocket [chemical binding]; other site 266264004858 CoA binding site [chemical binding]; other site 266264004859 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 266264004860 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266264004861 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264004862 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266264004863 Fe-S cluster binding site [ion binding]; other site 266264004864 active site 266264004865 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 266264004866 lysophospholipid transporter LplT; Provisional; Region: PRK11195 266264004867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264004868 alanine racemase; Reviewed; Region: dadX; PRK03646 266264004869 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 266264004870 active site 266264004871 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264004872 substrate binding site [chemical binding]; other site 266264004873 catalytic residues [active] 266264004874 dimer interface [polypeptide binding]; other site 266264004875 DNA repair protein RadA; Provisional; Region: PRK11823 266264004876 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 266264004877 Walker A motif/ATP binding site; other site 266264004878 ATP binding site [chemical binding]; other site 266264004879 Walker B motif; other site 266264004880 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 266264004881 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 266264004882 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 266264004883 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264004884 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264004885 ABC transporter; Region: ABC_tran_2; pfam12848 266264004886 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264004887 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266264004888 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266264004889 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266264004890 putative active site [active] 266264004891 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 266264004892 catalytic nucleophile [active] 266264004893 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 266264004894 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264004895 Walker A/P-loop; other site 266264004896 ATP binding site [chemical binding]; other site 266264004897 Q-loop/lid; other site 266264004898 ABC transporter signature motif; other site 266264004899 Walker B; other site 266264004900 D-loop; other site 266264004901 H-loop/switch region; other site 266264004902 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264004903 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264004904 Walker A/P-loop; other site 266264004905 ATP binding site [chemical binding]; other site 266264004906 Q-loop/lid; other site 266264004907 ABC transporter signature motif; other site 266264004908 Walker B; other site 266264004909 D-loop; other site 266264004910 H-loop/switch region; other site 266264004911 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264004912 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266264004913 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 266264004914 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 266264004915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264004916 dimer interface [polypeptide binding]; other site 266264004917 conserved gate region; other site 266264004918 putative PBP binding loops; other site 266264004919 ABC-ATPase subunit interface; other site 266264004920 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 266264004921 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266264004922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264004923 dimer interface [polypeptide binding]; other site 266264004924 conserved gate region; other site 266264004925 putative PBP binding loops; other site 266264004926 ABC-ATPase subunit interface; other site 266264004927 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 266264004928 homodimer interface [polypeptide binding]; other site 266264004929 homotetramer interface [polypeptide binding]; other site 266264004930 active site pocket [active] 266264004931 cleavage site 266264004932 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 266264004933 SxDxEG motif; other site 266264004934 active site 266264004935 metal binding site [ion binding]; metal-binding site 266264004936 homopentamer interface [polypeptide binding]; other site 266264004937 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 266264004938 putative active site [active] 266264004939 Zn binding site [ion binding]; other site 266264004940 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 266264004941 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266264004942 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264004943 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264004944 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266264004945 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266264004946 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264004947 Cytochrome c; Region: Cytochrom_C; cl11414 266264004948 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 266264004949 HemK family putative methylases; Region: hemK_fam; TIGR00536 266264004950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264004951 S-adenosylmethionine binding site [chemical binding]; other site 266264004952 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 266264004953 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 266264004954 metal binding site [ion binding]; metal-binding site 266264004955 dimer interface [polypeptide binding]; other site 266264004956 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 266264004957 ArsC family; Region: ArsC; pfam03960 266264004958 putative catalytic residues [active] 266264004959 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 266264004960 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 266264004961 trimer interface [polypeptide binding]; other site 266264004962 active site 266264004963 substrate binding site [chemical binding]; other site 266264004964 CoA binding site [chemical binding]; other site 266264004965 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 266264004966 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264004967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264004968 homodimer interface [polypeptide binding]; other site 266264004969 catalytic residue [active] 266264004970 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266264004971 dinuclear metal binding motif [ion binding]; other site 266264004972 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266264004973 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 266264004974 Walker A/P-loop; other site 266264004975 ATP binding site [chemical binding]; other site 266264004976 Q-loop/lid; other site 266264004977 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 266264004978 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 266264004979 ABC transporter signature motif; other site 266264004980 Walker B; other site 266264004981 D-loop; other site 266264004982 H-loop/switch region; other site 266264004983 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 266264004984 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 266264004985 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 266264004986 nucleotide binding pocket [chemical binding]; other site 266264004987 K-X-D-G motif; other site 266264004988 catalytic site [active] 266264004989 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 266264004990 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 266264004991 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 266264004992 Dimer interface [polypeptide binding]; other site 266264004993 BRCT sequence motif; other site 266264004994 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266264004995 active site 266264004996 catalytic residues [active] 266264004997 metal binding site [ion binding]; metal-binding site 266264004998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264004999 putative substrate translocation pore; other site 266264005000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264005002 MAEBL; Provisional; Region: PTZ00121 266264005003 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266264005004 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264005005 RNA binding surface [nucleotide binding]; other site 266264005006 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 266264005007 active site 266264005008 PII uridylyl-transferase; Provisional; Region: PRK03059 266264005009 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266264005010 metal binding triad; other site 266264005011 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266264005012 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266264005013 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 266264005014 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 266264005015 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266264005016 active site 266264005017 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 266264005018 rRNA interaction site [nucleotide binding]; other site 266264005019 S8 interaction site; other site 266264005020 putative laminin-1 binding site; other site 266264005021 elongation factor Ts; Provisional; Region: tsf; PRK09377 266264005022 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 266264005023 Elongation factor TS; Region: EF_TS; pfam00889 266264005024 Elongation factor TS; Region: EF_TS; pfam00889 266264005025 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 266264005026 putative nucleotide binding site [chemical binding]; other site 266264005027 uridine monophosphate binding site [chemical binding]; other site 266264005028 homohexameric interface [polypeptide binding]; other site 266264005029 ribosome recycling factor; Reviewed; Region: frr; PRK00083 266264005030 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 266264005031 hinge region; other site 266264005032 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 266264005033 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 266264005034 catalytic residue [active] 266264005035 putative FPP diphosphate binding site; other site 266264005036 putative FPP binding hydrophobic cleft; other site 266264005037 dimer interface [polypeptide binding]; other site 266264005038 putative IPP diphosphate binding site; other site 266264005039 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 266264005040 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 266264005041 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 266264005042 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 266264005043 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 266264005044 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266264005045 zinc metallopeptidase RseP; Provisional; Region: PRK10779 266264005046 active site 266264005047 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 266264005048 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 266264005049 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 266264005050 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266264005051 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266264005052 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266264005053 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266264005054 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266264005055 Surface antigen; Region: Bac_surface_Ag; cl03097 266264005056 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 266264005057 periplasmic chaperone; Provisional; Region: PRK10780 266264005058 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 266264005059 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 266264005060 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 266264005061 trimer interface [polypeptide binding]; other site 266264005062 active site 266264005063 UDP-GlcNAc binding site [chemical binding]; other site 266264005064 lipid binding site [chemical binding]; lipid-binding site 266264005065 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 266264005066 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 266264005067 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 266264005068 active site 266264005069 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 266264005070 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 266264005071 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 266264005072 RNA/DNA hybrid binding site [nucleotide binding]; other site 266264005073 active site 266264005074 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266264005075 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 266264005076 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 266264005077 phosphoenolpyruvate synthase; Validated; Region: PRK06464 266264005078 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 266264005079 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 266264005080 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266264005081 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266264005082 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 266264005083 SmpB-tmRNA interface; other site 266264005084 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 266264005085 putative coenzyme Q binding site [chemical binding]; other site 266264005086 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 266264005087 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 266264005088 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 266264005089 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 266264005090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 266264005091 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 266264005092 active site 266264005093 GMP synthase; Reviewed; Region: guaA; PRK00074 266264005094 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 266264005095 AMP/PPi binding site [chemical binding]; other site 266264005096 candidate oxyanion hole; other site 266264005097 catalytic triad [active] 266264005098 potential glutamine specificity residues [chemical binding]; other site 266264005099 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 266264005100 ATP Binding subdomain [chemical binding]; other site 266264005101 Ligand Binding sites [chemical binding]; other site 266264005102 Dimerization subdomain; other site 266264005103 integrase; Provisional; Region: PRK09692 266264005104 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266264005105 active site 266264005106 Int/Topo IB signature motif; other site 266264005107 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264005108 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264005109 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266264005110 active site 266264005111 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 266264005112 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 266264005113 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 266264005114 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 266264005115 putative active site [active] 266264005116 putative NTP binding site [chemical binding]; other site 266264005117 putative nucleic acid binding site [nucleotide binding]; other site 266264005118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264005119 non-specific DNA binding site [nucleotide binding]; other site 266264005120 salt bridge; other site 266264005121 sequence-specific DNA binding site [nucleotide binding]; other site 266264005122 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266264005123 Domain of unknown function (DUF932); Region: DUF932; cl12129 266264005124 ParB-like nuclease domain; Region: ParBc; cl02129 266264005125 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 266264005126 Protein of unknown function (DUF736); Region: DUF736; cl02303 266264005127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264005128 non-specific DNA binding site [nucleotide binding]; other site 266264005129 salt bridge; other site 266264005130 sequence-specific DNA binding site [nucleotide binding]; other site 266264005131 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266264005132 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 266264005133 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264005134 Replication initiator protein A; Region: RPA; cl02339 266264005135 ParA-like protein; Provisional; Region: PHA02518 266264005136 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264005137 P-loop; other site 266264005138 Magnesium ion binding site [ion binding]; other site 266264005139 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266264005140 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 266264005141 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266264005142 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 266264005143 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266264005144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264005145 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264005146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264005147 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264005148 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264005149 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266264005150 intersubunit interface [polypeptide binding]; other site 266264005151 active site 266264005152 zinc binding site [ion binding]; other site 266264005153 Na+ binding site [ion binding]; other site 266264005154 Ribosomal RNA small subunit methyltransferase B (rRNA (cytosine-C(5)-)-methyltransferase) (16S rRNA m5C967 methyltransferase) (fragment) 266264005155 conserved hypothetical protein with HAD-superfamily hydrolase domain (fragment) 266264005156 conserved hypothetical protein with HAD-superfamily hydrolase domain (fragment) 266264005157 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 266264005158 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 266264005159 metal ion-dependent adhesion site (MIDAS); other site 266264005160 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264005161 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 266264005162 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 266264005163 multimerization interface [polypeptide binding]; other site 266264005164 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 266264005165 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 266264005166 dimer interface [polypeptide binding]; other site 266264005167 catalytic residue [active] 266264005168 metal binding site [ion binding]; metal-binding site 266264005169 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005170 Helix-turn-helix domains; Region: HTH; cl00088 266264005171 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 266264005172 putative dimerization interface [polypeptide binding]; other site 266264005173 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266264005174 MULE transposase domain; Region: MULE; pfam10551 266264005175 transposase (part 2) IS1595 family 266264005176 transposase (part 1) 266264005177 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264005178 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264005179 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 266264005180 metal binding site [ion binding]; metal-binding site 266264005181 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 266264005182 Helix-turn-helix domains; Region: HTH; cl00088 266264005183 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 266264005184 putative dimerization interface [polypeptide binding]; other site 266264005185 hypothetical protein 266264005186 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266264005187 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 266264005188 substrate binding site [chemical binding]; other site 266264005189 hexamer interface [polypeptide binding]; other site 266264005190 metal binding site [ion binding]; metal-binding site 266264005191 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 266264005192 AMP binding site [chemical binding]; other site 266264005193 metal binding site [ion binding]; metal-binding site 266264005194 active site 266264005195 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264005196 transketolase; Reviewed; Region: PRK12753 266264005197 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266264005198 TPP-binding site [chemical binding]; other site 266264005199 dimer interface [polypeptide binding]; other site 266264005200 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266264005201 PYR/PP interface [polypeptide binding]; other site 266264005202 dimer interface [polypeptide binding]; other site 266264005203 TPP binding site [chemical binding]; other site 266264005204 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266264005205 phosphoglycolate phosphatase; Provisional; Region: PRK13222 266264005206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264005207 motif II; other site 266264005208 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 266264005209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264005210 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 266264005211 Phosphoglycerate kinase; Region: PGK; pfam00162 266264005212 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 266264005213 substrate binding site [chemical binding]; other site 266264005214 hinge regions; other site 266264005215 ADP binding site [chemical binding]; other site 266264005216 catalytic site [active] 266264005217 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 266264005218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264005219 motif II; other site 266264005220 hypothetical protein; Provisional; Region: PRK08185 266264005221 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266264005222 intersubunit interface [polypeptide binding]; other site 266264005223 active site 266264005224 zinc binding site [ion binding]; other site 266264005225 Na+ binding site [ion binding]; other site 266264005226 pyruvate kinase; Provisional; Region: PRK06247 266264005227 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266264005228 domain interfaces; other site 266264005229 active site 266264005230 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266264005231 substrate binding site [chemical binding]; other site 266264005232 dimer interface [polypeptide binding]; other site 266264005233 catalytic triad [active] 266264005234 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 266264005235 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266264005236 active site 266264005237 dimer interface [polypeptide binding]; other site 266264005238 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 266264005239 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, hoxF; composed of proteins similar to the NAD-reducing hydrogenase (hoxS) alpha subunit of Alcaligenes eutrophus H16. HoxS is a cytoplasmic hydrogenase...; Region: TRX_Fd_NuoE_hoxF; cd03083 266264005240 putative dimer interface [polypeptide binding]; other site 266264005241 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266264005242 SLBB domain; Region: SLBB; pfam10531 266264005243 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 266264005244 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266264005245 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 266264005246 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 266264005247 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 266264005248 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 266264005249 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 266264005250 nickel binding site [ion binding]; other site 266264005251 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264005252 ligand binding site [chemical binding]; other site 266264005253 flexible hinge region; other site 266264005254 pyridine nucleotide transhydrogenase, alpha subunit (part 1) 266264005255 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264005256 Helix-turn-helix domains; Region: HTH; cl00088 266264005257 Integrase core domain; Region: rve; cl01316 266264005258 pyridine nucleotide transhydrogenase, alpha subunit (part 2) 266264005259 pyridine nucleotide transhydrogenase (proton pump), alpha subunit (fragment) 266264005260 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 266264005261 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 266264005262 High-affinity nickel-transport protein; Region: NicO; cl00964 266264005263 putative hydrogenase expression/formation 266264005264 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 266264005265 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 266264005266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264005267 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 266264005268 Acylphosphatase; Region: Acylphosphatase; cl00551 266264005269 HypF finger; Region: zf-HYPF; pfam07503 266264005270 HypF finger; Region: zf-HYPF; pfam07503 266264005271 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 266264005272 HupF/HypC family; Region: HupF_HypC; cl00394 266264005273 Hydrogenase formation hypA family; Region: HypD; cl12072 266264005274 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 266264005275 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 266264005276 dimerization interface [polypeptide binding]; other site 266264005277 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 266264005278 ATP binding site [chemical binding]; other site 266264005279 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 266264005280 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 266264005281 putative active site [active] 266264005282 putative substrate binding site [chemical binding]; other site 266264005283 putative cosubstrate binding site; other site 266264005284 catalytic site [active] 266264005285 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 266264005286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264005287 substrate binding site [chemical binding]; other site 266264005288 oxyanion hole (OAH) forming residues; other site 266264005289 trimer interface [polypeptide binding]; other site 266264005290 Response regulator receiver domain; Region: Response_reg; pfam00072 266264005291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005292 active site 266264005293 phosphorylation site [posttranslational modification] 266264005294 intermolecular recognition site; other site 266264005295 dimerization interface [polypeptide binding]; other site 266264005296 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 266264005297 Fragment of fructose-bisphosphate aldolase (cbbA) 266264005298 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264005299 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264005300 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264005301 Helix-turn-helix domains; Region: HTH; cl00088 266264005302 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264005303 dimerization interface [polypeptide binding]; other site 266264005304 substrate binding pocket [chemical binding]; other site 266264005305 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266264005306 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264005307 Walker A motif; other site 266264005308 ATP binding site [chemical binding]; other site 266264005309 Walker B motif; other site 266264005310 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 266264005311 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 266264005312 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266264005313 ATP binding site [chemical binding]; other site 266264005314 Walker A motif; other site 266264005315 hexamer interface [polypeptide binding]; other site 266264005316 Walker B motif; other site 266264005317 TrbC/VIRB2 family; Region: TrbC; cl01583 266264005318 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266264005319 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266264005320 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266264005321 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264005322 Walker A motif; other site 266264005323 ATP binding site [chemical binding]; other site 266264005324 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 266264005325 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 266264005326 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266264005327 conjugal transfer protein TrbL; Provisional; Region: PRK13875 266264005328 VirB8 protein; Region: VirB8; cl01500 266264005329 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266264005330 VirB7 interaction site; other site 266264005331 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 266264005332 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 266264005333 Protein of unknown function (DUF2274); Region: DUF2274; cl02406 266264005334 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 266264005335 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 266264005336 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 266264005337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264005338 Helix-turn-helix domains; Region: HTH; cl00088 266264005339 Helix-turn-helix domains; Region: HTH; cl00088 266264005340 putative transposase OrfB; Reviewed; Region: PHA02517 266264005341 HTH-like domain; Region: HTH_21; pfam13276 266264005342 Integrase core domain; Region: rve; cl01316 266264005343 Integrase core domain; Region: rve_3; cl15866 266264005344 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266264005345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264005346 NAD(P) binding pocket [chemical binding]; other site 266264005347 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264005348 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264005349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264005350 Helix-turn-helix domains; Region: HTH; cl00088 266264005351 PAS domain S-box; Region: sensory_box; TIGR00229 266264005352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264005353 putative active site [active] 266264005354 heme pocket [chemical binding]; other site 266264005355 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 266264005356 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 266264005357 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 266264005358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264005359 FeS/SAM binding site; other site 266264005360 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266264005361 active site 266264005362 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266264005363 nucleoside/Zn binding site; other site 266264005364 dimer interface [polypeptide binding]; other site 266264005365 catalytic motif [active] 266264005366 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 266264005367 dimer interface [polypeptide binding]; other site 266264005368 catalytic triad [active] 266264005369 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 266264005370 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264005371 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264005372 ABC transporter; Region: ABC_tran_2; pfam12848 266264005373 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264005374 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266264005375 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264005376 NAD binding site [chemical binding]; other site 266264005377 catalytic residues [active] 266264005378 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 266264005379 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266264005380 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 266264005381 active site 266264005382 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266264005383 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266264005384 catalytic triad [active] 266264005385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 266264005386 MOSC domain; Region: MOSC; pfam03473 266264005387 3-alpha domain; Region: 3-alpha; pfam03475 266264005388 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 266264005389 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264005390 CoenzymeA binding site [chemical binding]; other site 266264005391 subunit interaction site [polypeptide binding]; other site 266264005392 PHB binding site; other site 266264005393 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 266264005394 active site 266264005395 homodimer interface [polypeptide binding]; other site 266264005396 homotetramer interface [polypeptide binding]; other site 266264005397 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 266264005398 PrpF protein; Region: PrpF; pfam04303 266264005399 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 266264005400 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266264005401 substrate binding site [chemical binding]; other site 266264005402 ligand binding site [chemical binding]; other site 266264005403 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 266264005404 substrate binding site [chemical binding]; other site 266264005405 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266264005406 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 266264005407 dimer interface [polypeptide binding]; other site 266264005408 active site 266264005409 citrylCoA binding site [chemical binding]; other site 266264005410 oxalacetate/citrate binding site [chemical binding]; other site 266264005411 coenzyme A binding site [chemical binding]; other site 266264005412 catalytic triad [active] 266264005413 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 266264005414 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266264005415 tetramer interface [polypeptide binding]; other site 266264005416 active site 266264005417 Mg2+/Mn2+ binding site [ion binding]; other site 266264005418 Propionate catabolism activator; Region: PrpR_N; pfam06506 266264005419 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 266264005420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264005421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264005422 Walker A motif; other site 266264005423 ATP binding site [chemical binding]; other site 266264005424 Walker B motif; other site 266264005425 arginine finger; other site 266264005426 Helix-turn-helix domains; Region: HTH; cl00088 266264005427 TIGR03440 family protein; Region: unchr_TIGR03440 266264005428 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 266264005429 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264005430 transcriptional activator, LysR family (fragment) 266264005431 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264005432 Helix-turn-helix domains; Region: HTH; cl00088 266264005433 Integrase core domain; Region: rve; cl01316 266264005434 transcriptional regulator, LysR-family (fragment) 266264005435 DoxX; Region: DoxX; cl00976 266264005436 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 266264005437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264005438 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 266264005439 Cupin domain; Region: Cupin_2; cl09118 266264005440 NMT1-like family; Region: NMT1_2; cl15260 266264005441 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266264005442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264005443 dimer interface [polypeptide binding]; other site 266264005444 conserved gate region; other site 266264005445 putative PBP binding loops; other site 266264005446 ABC-ATPase subunit interface; other site 266264005447 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264005448 Cytochrome c; Region: Cytochrom_C; cl11414 266264005449 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 266264005450 Helix-turn-helix domains; Region: HTH; cl00088 266264005451 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264005452 Surface antigen; Region: Bac_surface_Ag; cl03097 266264005453 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266264005454 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264005455 Cupin domain; Region: Cupin_2; cl09118 266264005456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264005457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264005458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005459 Helix-turn-helix domains; Region: HTH; cl00088 266264005460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264005461 dimerization interface [polypeptide binding]; other site 266264005462 LrgA family; Region: LrgA; cl00608 266264005463 LrgB-like family; Region: LrgB; cl00596 266264005464 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264005465 FAD binding domain; Region: FAD_binding_4; pfam01565 266264005466 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264005467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264005468 DNA-binding site [nucleotide binding]; DNA binding site 266264005469 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264005470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264005471 homodimer interface [polypeptide binding]; other site 266264005472 catalytic residue [active] 266264005473 acetylornithine deacetylase; Provisional; Region: PRK06837 266264005474 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 266264005475 metal binding site [ion binding]; metal-binding site 266264005476 dimer interface [polypeptide binding]; other site 266264005477 putative extracellular solute-binding protein, family 5 (fragment) 266264005478 putative transposase OrfB; Reviewed; Region: PHA02517 266264005479 HTH-like domain; Region: HTH_21; pfam13276 266264005480 Integrase core domain; Region: rve; cl01316 266264005481 Integrase core domain; Region: rve_3; cl15866 266264005482 Helix-turn-helix domains; Region: HTH; cl00088 266264005483 Putative solute-binding transport protein (Periplasmic) (fragment) 266264005484 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266264005485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264005486 dimer interface [polypeptide binding]; other site 266264005487 conserved gate region; other site 266264005488 putative PBP binding loops; other site 266264005489 ABC-ATPase subunit interface; other site 266264005490 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266264005491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264005492 dimer interface [polypeptide binding]; other site 266264005493 conserved gate region; other site 266264005494 putative PBP binding loops; other site 266264005495 ABC-ATPase subunit interface; other site 266264005496 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266264005497 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264005498 Walker A/P-loop; other site 266264005499 ATP binding site [chemical binding]; other site 266264005500 Q-loop/lid; other site 266264005501 ABC transporter signature motif; other site 266264005502 Walker B; other site 266264005503 D-loop; other site 266264005504 H-loop/switch region; other site 266264005505 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264005506 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264005507 Walker A/P-loop; other site 266264005508 ATP binding site [chemical binding]; other site 266264005509 Q-loop/lid; other site 266264005510 ABC transporter signature motif; other site 266264005511 Walker B; other site 266264005512 D-loop; other site 266264005513 H-loop/switch region; other site 266264005514 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264005515 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 266264005516 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264005517 inhibitor-cofactor binding pocket; inhibition site 266264005518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264005519 catalytic residue [active] 266264005520 Cupin domain; Region: Cupin_2; cl09118 266264005521 thiamine pyrophosphate protein; Validated; Region: PRK08199 266264005522 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264005523 PYR/PP interface [polypeptide binding]; other site 266264005524 dimer interface [polypeptide binding]; other site 266264005525 TPP binding site [chemical binding]; other site 266264005526 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266264005527 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266264005528 TPP-binding site [chemical binding]; other site 266264005529 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 266264005530 allantoate amidohydrolase; Reviewed; Region: PRK12893 266264005531 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266264005532 active site 266264005533 metal binding site [ion binding]; metal-binding site 266264005534 dimer interface [polypeptide binding]; other site 266264005535 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 266264005536 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 266264005537 NAD(P) binding site [chemical binding]; other site 266264005538 catalytic residues [active] 266264005539 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264005540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005541 putative substrate translocation pore; other site 266264005542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005543 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264005544 Helix-turn-helix domains; Region: HTH; cl00088 266264005545 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266264005546 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264005547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264005548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264005549 dimer interface [polypeptide binding]; other site 266264005550 phosphorylation site [posttranslational modification] 266264005551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264005552 ATP binding site [chemical binding]; other site 266264005553 Mg2+ binding site [ion binding]; other site 266264005554 G-X-G motif; other site 266264005555 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266264005556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005557 active site 266264005558 phosphorylation site [posttranslational modification] 266264005559 intermolecular recognition site; other site 266264005560 dimerization interface [polypeptide binding]; other site 266264005561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264005562 DNA binding site [nucleotide binding] 266264005563 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264005564 trimer interface [polypeptide binding]; other site 266264005565 eyelet of channel; other site 266264005566 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266264005567 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266264005568 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266264005569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005570 Helix-turn-helix domains; Region: HTH; cl00088 266264005571 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266264005572 putative dimerization interface [polypeptide binding]; other site 266264005573 tartronate semialdehyde reductase; Provisional; Region: PRK15059 266264005574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264005575 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266264005576 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 266264005577 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266264005578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264005579 NMT1-like family; Region: NMT1_2; cl15260 266264005580 thiamine pyrophosphate protein; Validated; Region: PRK08199 266264005581 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264005582 PYR/PP interface [polypeptide binding]; other site 266264005583 dimer interface [polypeptide binding]; other site 266264005584 TPP binding site [chemical binding]; other site 266264005585 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266264005586 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266264005587 TPP-binding site [chemical binding]; other site 266264005588 pyruvate carboxylase; Reviewed; Region: PRK12999 266264005589 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264005590 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264005591 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266264005592 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 266264005593 active site 266264005594 catalytic residues [active] 266264005595 metal binding site [ion binding]; metal-binding site 266264005596 homodimer binding site [polypeptide binding]; other site 266264005597 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264005598 carboxyltransferase (CT) interaction site; other site 266264005599 biotinylation site [posttranslational modification]; other site 266264005600 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264005601 trimer interface [polypeptide binding]; other site 266264005602 eyelet of channel; other site 266264005603 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264005604 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 266264005605 putative ligand binding site [chemical binding]; other site 266264005606 Putative cyclase; Region: Cyclase; cl00814 266264005607 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266264005608 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264005609 DNA polymerase II; Reviewed; Region: PRK05762 266264005610 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 266264005611 active site 266264005612 catalytic site [active] 266264005613 substrate binding site [chemical binding]; other site 266264005614 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 266264005615 active site 266264005616 metal-binding site 266264005617 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264005618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 266264005619 Anti-sigma-K factor rskA; Region: RskA; pfam10099 266264005620 RNA polymerase sigma factor; Provisional; Region: PRK12514 266264005621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264005622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264005623 DNA binding residues [nucleotide binding] 266264005624 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266264005625 dinuclear metal binding motif [ion binding]; other site 266264005626 Inner membrane protein CreD; Region: CreD; cl01844 266264005627 sensory histidine kinase CreC; Provisional; Region: PRK11100 266264005628 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264005629 dimerization interface [polypeptide binding]; other site 266264005630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264005631 dimer interface [polypeptide binding]; other site 266264005632 phosphorylation site [posttranslational modification] 266264005633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264005634 ATP binding site [chemical binding]; other site 266264005635 Mg2+ binding site [ion binding]; other site 266264005636 G-X-G motif; other site 266264005637 DNA-binding response regulator CreB; Provisional; Region: PRK11083 266264005638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005639 active site 266264005640 phosphorylation site [posttranslational modification] 266264005641 intermolecular recognition site; other site 266264005642 dimerization interface [polypeptide binding]; other site 266264005643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264005644 DNA binding site [nucleotide binding] 266264005645 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266264005646 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 266264005647 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 266264005648 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266264005649 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 266264005650 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266264005651 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 266264005652 putative dimer interface [polypeptide binding]; other site 266264005653 N-terminal domain interface [polypeptide binding]; other site 266264005654 putative substrate binding pocket (H-site) [chemical binding]; other site 266264005655 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 266264005656 putative ligand binding site [chemical binding]; other site 266264005657 putative catalytic site [active] 266264005658 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 266264005659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266264005660 Integrase core domain; Region: rve; cl01316 266264005661 Integrase core domain; Region: rve; cl01316 266264005662 hypothetical protein 266264005663 IS66-like transposase remnant 266264005664 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266264005665 transposase remnant 266264005666 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 266264005667 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266264005668 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266264005669 Fimbrial protein; Region: Fimbrial; cl01416 266264005670 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266264005671 PapC N-terminal domain; Region: PapC_N; pfam13954 266264005672 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266264005673 PapC C-terminal domain; Region: PapC_C; pfam13953 266264005674 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266264005675 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266264005676 Fimbrial protein; Region: Fimbrial; cl01416 266264005677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266264005678 Integrase core domain; Region: rve; cl01316 266264005679 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266264005680 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264005681 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 266264005682 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266264005683 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266264005684 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 266264005685 dimer interaction site [polypeptide binding]; other site 266264005686 substrate-binding tunnel; other site 266264005687 active site 266264005688 catalytic site [active] 266264005689 substrate binding site [chemical binding]; other site 266264005690 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 266264005691 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 266264005692 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 266264005693 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 266264005694 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264005695 Ligand Binding Site [chemical binding]; other site 266264005696 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264005697 Ligand Binding Site [chemical binding]; other site 266264005698 phage integrase family protein (fragment) 266264005699 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 266264005700 NeuB family; Region: NeuB; cl00496 266264005701 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266264005702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264005703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005704 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 266264005705 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266264005706 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266264005707 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264005708 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266264005709 Walker A/P-loop; other site 266264005710 ATP binding site [chemical binding]; other site 266264005711 Q-loop/lid; other site 266264005712 ABC transporter signature motif; other site 266264005713 Walker B; other site 266264005714 D-loop; other site 266264005715 H-loop/switch region; other site 266264005716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264005717 Walker A/P-loop; other site 266264005718 ATP binding site [chemical binding]; other site 266264005719 Q-loop/lid; other site 266264005720 ABC transporter signature motif; other site 266264005721 Walker B; other site 266264005722 D-loop; other site 266264005723 H-loop/switch region; other site 266264005724 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266264005725 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266264005726 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 266264005727 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264005728 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264005729 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264005730 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 266264005731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264005732 PAS domain; Region: PAS_9; pfam13426 266264005733 putative active site [active] 266264005734 heme pocket [chemical binding]; other site 266264005735 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264005736 metal binding site [ion binding]; metal-binding site 266264005737 active site 266264005738 I-site; other site 266264005739 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264005740 hypothetical protein 266264005741 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 266264005742 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 266264005743 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 266264005744 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264005745 ligand binding site [chemical binding]; other site 266264005746 flexible hinge region; other site 266264005747 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264005748 non-specific DNA interactions [nucleotide binding]; other site 266264005749 DNA binding site [nucleotide binding] 266264005750 sequence specific DNA binding site [nucleotide binding]; other site 266264005751 putative cAMP binding site [chemical binding]; other site 266264005752 hypothetical protein 266264005753 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 266264005754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264005755 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 266264005756 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 266264005757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264005758 dimer interface [polypeptide binding]; other site 266264005759 phosphorylation site [posttranslational modification] 266264005760 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 266264005761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264005762 ATP binding site [chemical binding]; other site 266264005763 G-X-G motif; other site 266264005764 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266264005765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005766 active site 266264005767 phosphorylation site [posttranslational modification] 266264005768 intermolecular recognition site; other site 266264005769 dimerization interface [polypeptide binding]; other site 266264005770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264005771 DNA binding residues [nucleotide binding] 266264005772 dimerization interface [polypeptide binding]; other site 266264005773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005774 Response regulator receiver domain; Region: Response_reg; pfam00072 266264005775 active site 266264005776 phosphorylation site [posttranslational modification] 266264005777 intermolecular recognition site; other site 266264005778 dimerization interface [polypeptide binding]; other site 266264005779 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586 266264005780 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264005781 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264005782 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264005783 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266264005784 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264005785 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264005786 active site 266264005787 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266264005788 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 266264005789 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264005790 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266264005791 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264005792 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264005793 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 266264005794 Ion channel; Region: Ion_trans_2; cl11596 266264005795 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264005796 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264005797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264005798 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266264005799 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266264005800 NADP binding site [chemical binding]; other site 266264005801 dimer interface [polypeptide binding]; other site 266264005802 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264005803 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264005804 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264005805 AMP-binding enzyme; Region: AMP-binding; cl15778 266264005806 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264005807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264005808 NMT1-like family; Region: NMT1_2; cl15260 266264005809 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264005810 Helix-turn-helix domains; Region: HTH; cl00088 266264005811 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266264005812 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266264005813 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264005814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264005815 active site 266264005816 enoyl-CoA hydratase; Provisional; Region: PRK05995 266264005817 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264005818 substrate binding site [chemical binding]; other site 266264005819 oxyanion hole (OAH) forming residues; other site 266264005820 trimer interface [polypeptide binding]; other site 266264005821 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266264005822 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264005823 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264005824 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266264005825 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264005826 carboxyltransferase (CT) interaction site; other site 266264005827 biotinylation site [posttranslational modification]; other site 266264005828 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 266264005829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264005830 NMT1-like family; Region: NMT1_2; cl15260 266264005831 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264005832 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264005833 major facilitator superfamily (MFS) metabolite/H+ symporter (fragment) 266264005834 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 266264005835 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266264005836 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264005837 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264005838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264005839 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264005840 trimer interface [polypeptide binding]; other site 266264005841 eyelet of channel; other site 266264005842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264005843 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 266264005844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005845 putative substrate translocation pore; other site 266264005846 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266264005847 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264005848 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 266264005849 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266264005850 DXD motif; other site 266264005851 PilZ domain; Region: PilZ; cl01260 266264005852 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266264005853 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264005854 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264005855 Ligand Binding Site [chemical binding]; other site 266264005856 TIGR03442 family protein; Region: TIGR03442 266264005857 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 266264005858 putative active site [active] 266264005859 putative dimer interface [polypeptide binding]; other site 266264005860 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264005861 AMP-binding domain protein; Validated; Region: PRK07529 266264005862 AMP-binding enzyme; Region: AMP-binding; cl15778 266264005863 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 266264005864 AAA domain; Region: AAA_33; pfam13671 266264005865 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264005866 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264005867 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264005868 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264005869 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266264005870 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266264005871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005872 active site 266264005873 phosphorylation site [posttranslational modification] 266264005874 intermolecular recognition site; other site 266264005875 dimerization interface [polypeptide binding]; other site 266264005876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264005877 DNA binding site [nucleotide binding] 266264005878 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264005879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264005880 dimer interface [polypeptide binding]; other site 266264005881 phosphorylation site [posttranslational modification] 266264005882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264005883 ATP binding site [chemical binding]; other site 266264005884 Mg2+ binding site [ion binding]; other site 266264005885 G-X-G motif; other site 266264005886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264005887 NMT1-like family; Region: NMT1_2; cl15260 266264005888 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264005889 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264005890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005891 Helix-turn-helix domains; Region: HTH; cl00088 266264005892 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264005893 putative effector binding pocket; other site 266264005894 dimerization interface [polypeptide binding]; other site 266264005895 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 266264005896 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266264005897 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264005898 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264005899 ABC transporter; Region: ABC_tran_2; pfam12848 266264005900 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264005901 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264005902 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264005903 Integral membrane protein TerC family; Region: TerC; cl10468 266264005904 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266264005905 Transporter associated domain; Region: CorC_HlyC; cl08393 266264005906 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264005907 hypothetical protein 266264005908 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 266264005909 Protein of unknown function (DUF419); Region: DUF419; cl15265 266264005910 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 266264005911 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264005912 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264005913 catalytic residue [active] 266264005914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005915 Helix-turn-helix domains; Region: HTH; cl00088 266264005916 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264005917 dimerization interface [polypeptide binding]; other site 266264005918 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 266264005919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264005920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264005921 NMT1-like family; Region: NMT1_2; cl15260 266264005922 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266264005923 Amidase; Region: Amidase; cl11426 266264005924 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 266264005925 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266264005926 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264005927 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 266264005928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264005929 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264005930 Helix-turn-helix domains; Region: HTH; cl00088 266264005931 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264005932 dimerization interface [polypeptide binding]; other site 266264005933 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264005934 FAD binding domain; Region: FAD_binding_4; pfam01565 266264005935 Berberine and berberine like; Region: BBE; pfam08031 266264005936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264005937 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 266264005938 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266264005939 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266264005940 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 266264005941 dimer interface [polypeptide binding]; other site 266264005942 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264005943 ligand binding site [chemical binding]; other site 266264005944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264005945 S-adenosylmethionine binding site [chemical binding]; other site 266264005946 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 266264005947 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 266264005948 dimer interface [polypeptide binding]; other site 266264005949 active site 266264005950 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266264005951 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264005952 catalytic loop [active] 266264005953 iron binding site [ion binding]; other site 266264005954 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 266264005955 FAD binding pocket [chemical binding]; other site 266264005956 FAD binding motif [chemical binding]; other site 266264005957 phosphate binding motif [ion binding]; other site 266264005958 beta-alpha-beta structure motif; other site 266264005959 NAD binding pocket [chemical binding]; other site 266264005960 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 266264005961 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 266264005962 dimerization interface [polypeptide binding]; other site 266264005963 putative path to active site cavity [active] 266264005964 diiron center [ion binding]; other site 266264005965 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 266264005966 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 266264005967 dimerization interface [polypeptide binding]; other site 266264005968 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 266264005969 Activator of aromatic catabolism; Region: XylR_N; pfam06505 266264005970 Heme NO binding; Region: HNOB; cl15268 266264005971 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 266264005972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264005973 Walker A motif; other site 266264005974 ATP binding site [chemical binding]; other site 266264005975 Walker B motif; other site 266264005976 arginine finger; other site 266264005977 Helix-turn-helix domains; Region: HTH; cl00088 266264005978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264005979 DNA-binding site [nucleotide binding]; DNA binding site 266264005980 FCD domain; Region: FCD; cl11656 266264005981 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264005982 FAD binding domain; Region: FAD_binding_4; pfam01565 266264005983 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264005984 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264005985 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266264005986 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266264005987 Walker A/P-loop; other site 266264005988 ATP binding site [chemical binding]; other site 266264005989 Q-loop/lid; other site 266264005990 ABC transporter signature motif; other site 266264005991 Walker B; other site 266264005992 D-loop; other site 266264005993 H-loop/switch region; other site 266264005994 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266264005995 FtsX-like permease family; Region: FtsX; cl15850 266264005996 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266264005997 FtsX-like permease family; Region: FtsX; cl15850 266264005998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005999 Helix-turn-helix domains; Region: HTH; cl00088 266264006000 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 266264006001 putative dimerization interface [polypeptide binding]; other site 266264006002 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266264006003 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 266264006004 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266264006005 putative hydrophobic ligand binding site [chemical binding]; other site 266264006006 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 266264006007 putative hydrophobic ligand binding site [chemical binding]; other site 266264006008 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264006009 dimerization interface [polypeptide binding]; other site 266264006010 putative DNA binding site [nucleotide binding]; other site 266264006011 Predicted transcriptional regulators [Transcription]; Region: COG1510 266264006012 putative Zn2+ binding site [ion binding]; other site 266264006013 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264006014 Helix-turn-helix domains; Region: HTH; cl00088 266264006015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264006016 NMT1-like family; Region: NMT1_2; cl15260 266264006017 Sulfatase; Region: Sulfatase; cl10460 266264006018 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266264006019 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266264006020 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264006021 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 266264006022 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266264006023 active site 266264006024 metal-binding site 266264006025 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 266264006026 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266264006027 tetramer interface [polypeptide binding]; other site 266264006028 active site 266264006029 Mg2+/Mn2+ binding site [ion binding]; other site 266264006030 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266264006031 active site 266264006032 metal-binding site 266264006033 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264006034 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 266264006035 PYR/PP interface [polypeptide binding]; other site 266264006036 dimer interface [polypeptide binding]; other site 266264006037 TPP binding site [chemical binding]; other site 266264006038 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 266264006039 TPP-binding site; other site 266264006040 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 266264006041 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264006042 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264006043 catalytic residue [active] 266264006044 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 266264006045 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 266264006046 putative active site [active] 266264006047 catalytic site [active] 266264006048 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 266264006049 putative active site [active] 266264006050 catalytic site [active] 266264006051 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266264006052 [2Fe-2S] cluster binding site [ion binding]; other site 266264006053 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266264006054 hydrophobic ligand binding site; other site 266264006055 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264006056 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264006057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264006058 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266264006059 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264006060 active site 266264006061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264006062 NMT1-like family; Region: NMT1_2; cl15260 266264006063 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264006064 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264006065 active site 266264006066 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264006067 Helix-turn-helix domains; Region: HTH; cl00088 266264006068 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264006069 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264006070 Helix-turn-helix domains; Region: HTH; cl00088 266264006071 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264006072 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264006073 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264006074 N-terminal plug; other site 266264006075 ligand-binding site [chemical binding]; other site 266264006076 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 266264006077 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 266264006078 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264006079 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264006080 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 266264006081 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 266264006082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264006083 Zn2+ binding site [ion binding]; other site 266264006084 Mg2+ binding site [ion binding]; other site 266264006085 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266264006086 HSP70 interaction site [polypeptide binding]; other site 266264006087 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266264006088 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266264006089 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266264006090 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266264006091 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266264006092 active site 266264006093 PilZ domain; Region: PilZ; cl01260 266264006094 DNA polymerase III subunit delta'; Validated; Region: PRK06964 266264006095 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264006096 thymidylate kinase; Validated; Region: tmk; PRK00698 266264006097 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 266264006098 TMP-binding site; other site 266264006099 ATP-binding site [chemical binding]; other site 266264006100 YceG-like family; Region: YceG; pfam02618 266264006101 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 266264006102 dimerization interface [polypeptide binding]; other site 266264006103 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 266264006104 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 266264006105 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266264006106 NRDE protein; Region: NRDE; cl01315 266264006107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264006108 Coenzyme A binding pocket [chemical binding]; other site 266264006109 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264006110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264006111 DNA-binding site [nucleotide binding]; DNA binding site 266264006112 FCD domain; Region: FCD; cl11656 266264006113 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266264006114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264006115 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 266264006116 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266264006117 intersubunit interface [polypeptide binding]; other site 266264006118 active site 266264006119 Zn2+ binding site [ion binding]; other site 266264006120 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266264006121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006122 putative substrate translocation pore; other site 266264006123 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 266264006124 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 266264006125 putative NAD(P) binding site [chemical binding]; other site 266264006126 active site 266264006127 putative substrate binding site [chemical binding]; other site 266264006128 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264006129 active site 266264006130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264006131 NMT1-like family; Region: NMT1_2; cl15260 266264006132 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264006133 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266264006134 substrate binding pocket [chemical binding]; other site 266264006135 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 266264006136 putative ADP-ribose binding site [chemical binding]; other site 266264006137 putative active site [active] 266264006138 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264006139 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264006140 hypothetical protein; Provisional; Region: PRK06194 266264006141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264006142 NAD(P) binding site [chemical binding]; other site 266264006143 active site 266264006144 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264006145 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266264006146 C-terminal domain interface [polypeptide binding]; other site 266264006147 GSH binding site (G-site) [chemical binding]; other site 266264006148 dimer interface [polypeptide binding]; other site 266264006149 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266264006150 N-terminal domain interface [polypeptide binding]; other site 266264006151 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266264006152 intersubunit interface [polypeptide binding]; other site 266264006153 active site 266264006154 Zn2+ binding site [ion binding]; other site 266264006155 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 266264006156 Prostaglandin dehydrogenases; Region: PGDH; cd05288 266264006157 NAD(P) binding site [chemical binding]; other site 266264006158 substrate binding site [chemical binding]; other site 266264006159 dimer interface [polypeptide binding]; other site 266264006160 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264006161 CoenzymeA binding site [chemical binding]; other site 266264006162 subunit interaction site [polypeptide binding]; other site 266264006163 PHB binding site; other site 266264006164 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 266264006165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264006166 NAD(P) binding site [chemical binding]; other site 266264006167 active site 266264006168 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266264006169 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266264006170 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 266264006171 FAD binding site [chemical binding]; other site 266264006172 substrate binding site [chemical binding]; other site 266264006173 catalytic residues [active] 266264006174 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266264006175 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 266264006176 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264006177 dimer interface [polypeptide binding]; other site 266264006178 active site 266264006179 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 266264006180 Isochorismatase family; Region: Isochorismatase; pfam00857 266264006181 catalytic triad [active] 266264006182 metal binding site [ion binding]; metal-binding site 266264006183 conserved cis-peptide bond; other site 266264006184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264006185 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266264006186 substrate binding site [chemical binding]; other site 266264006187 oxyanion hole (OAH) forming residues; other site 266264006188 trimer interface [polypeptide binding]; other site 266264006189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264006190 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264006191 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264006192 lysine transporter; Provisional; Region: PRK10836 266264006193 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264006194 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264006195 Walker A/P-loop; other site 266264006196 ATP binding site [chemical binding]; other site 266264006197 Q-loop/lid; other site 266264006198 ABC transporter signature motif; other site 266264006199 Walker B; other site 266264006200 D-loop; other site 266264006201 H-loop/switch region; other site 266264006202 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264006203 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264006204 Walker A/P-loop; other site 266264006205 ATP binding site [chemical binding]; other site 266264006206 Q-loop/lid; other site 266264006207 ABC transporter signature motif; other site 266264006208 Walker B; other site 266264006209 D-loop; other site 266264006210 H-loop/switch region; other site 266264006211 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264006212 TM-ABC transporter signature motif; other site 266264006213 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264006214 TM-ABC transporter signature motif; other site 266264006215 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264006216 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 266264006217 putative ligand binding site [chemical binding]; other site 266264006218 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 266264006219 AMP-binding enzyme; Region: AMP-binding; cl15778 266264006220 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264006221 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 266264006222 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 266264006223 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 266264006224 Intracellular septation protein A; Region: IspA; cl01098 266264006225 BolA-like protein; Region: BolA; cl00386 266264006226 SurA N-terminal domain; Region: SurA_N_3; cl07813 266264006227 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 266264006228 PPIC-type PPIASE domain; Region: Rotamase; cl08278 266264006229 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 266264006230 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 266264006231 dimerization interface [polypeptide binding]; other site 266264006232 ATP binding site [chemical binding]; other site 266264006233 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 266264006234 dimerization interface [polypeptide binding]; other site 266264006235 ATP binding site [chemical binding]; other site 266264006236 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 266264006237 putative active site [active] 266264006238 catalytic triad [active] 266264006239 Helix-turn-helix domains; Region: HTH; cl00088 266264006240 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 266264006241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264006242 metal binding site [ion binding]; metal-binding site 266264006243 active site 266264006244 I-site; other site 266264006245 amidase; Provisional; Region: PRK07056 266264006246 Amidase; Region: Amidase; cl11426 266264006247 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266264006248 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266264006249 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 266264006250 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 266264006251 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266264006252 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 266264006253 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 266264006254 putative substrate binding site [chemical binding]; other site 266264006255 putative ATP binding site [chemical binding]; other site 266264006256 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 266264006257 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 266264006258 active site 266264006259 dimer interface [polypeptide binding]; other site 266264006260 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 266264006261 dimer interface [polypeptide binding]; other site 266264006262 active site 266264006263 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266264006264 Q-loop/lid; other site 266264006265 ABC transporter signature motif; other site 266264006266 Walker B; other site 266264006267 D-loop; other site 266264006268 H-loop/switch region; other site 266264006269 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 266264006270 active site 266264006271 catalytic triad [active] 266264006272 oxyanion hole [active] 266264006273 switch loop; other site 266264006274 SurA N-terminal domain; Region: SurA_N_3; cl07813 266264006275 periplasmic folding chaperone; Provisional; Region: PRK10788 266264006276 PPIC-type PPIASE domain; Region: Rotamase; cl08278 266264006277 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 266264006278 Found in ATP-dependent protease La (LON); Region: LON; smart00464 266264006279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006280 Walker A motif; other site 266264006281 ATP binding site [chemical binding]; other site 266264006282 Walker B motif; other site 266264006283 arginine finger; other site 266264006284 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 266264006285 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 266264006286 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 266264006287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006288 Walker A motif; other site 266264006289 ATP binding site [chemical binding]; other site 266264006290 Walker B motif; other site 266264006291 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 266264006292 Clp protease; Region: CLP_protease; pfam00574 266264006293 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266264006294 oligomer interface [polypeptide binding]; other site 266264006295 active site residues [active] 266264006296 trigger factor; Provisional; Region: tig; PRK01490 266264006297 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 266264006298 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 266264006299 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 266264006300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264006301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264006302 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 266264006303 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 266264006304 PLD-like domain; Region: PLDc_2; pfam13091 266264006305 putative active site [active] 266264006306 catalytic site [active] 266264006307 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264006308 DNA binding residues [nucleotide binding] 266264006309 dimerization interface [polypeptide binding]; other site 266264006310 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 266264006311 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 266264006312 transcriptional regulator; Provisional; Region: PRK10632 266264006313 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264006314 putative effector binding pocket; other site 266264006315 dimerization interface [polypeptide binding]; other site 266264006316 hypothetical protein; Validated; Region: PRK07586 266264006317 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264006318 PYR/PP interface [polypeptide binding]; other site 266264006319 dimer interface [polypeptide binding]; other site 266264006320 TPP binding site [chemical binding]; other site 266264006321 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266264006322 TPP-binding site [chemical binding]; other site 266264006323 dimer interface [polypeptide binding]; other site 266264006324 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266264006325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264006326 Helix-turn-helix domains; Region: HTH; cl00088 266264006327 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266264006328 putative effector binding pocket; other site 266264006329 putative dimerization interface [polypeptide binding]; other site 266264006330 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266264006331 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264006332 NAD binding site [chemical binding]; other site 266264006333 catalytic residues [active] 266264006334 pyruvate dehydrogenase; Provisional; Region: PRK09124 266264006335 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 266264006336 PYR/PP interface [polypeptide binding]; other site 266264006337 dimer interface [polypeptide binding]; other site 266264006338 tetramer interface [polypeptide binding]; other site 266264006339 TPP binding site [chemical binding]; other site 266264006340 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266264006341 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 266264006342 TPP-binding site [chemical binding]; other site 266264006343 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266264006344 Helix-turn-helix domains; Region: HTH; cl00088 266264006345 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264006346 dimerization interface [polypeptide binding]; other site 266264006347 substrate binding pocket [chemical binding]; other site 266264006348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264006349 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 266264006350 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266264006351 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 266264006352 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266264006353 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266264006354 DNA binding site [nucleotide binding] 266264006355 domain linker motif; other site 266264006356 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266264006357 dimerization interface [polypeptide binding]; other site 266264006358 ligand binding site [chemical binding]; other site 266264006359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264006360 NMT1-like family; Region: NMT1_2; cl15260 266264006361 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264006362 trimer interface [polypeptide binding]; other site 266264006363 eyelet of channel; other site 266264006364 Cupin domain; Region: Cupin_2; cl09118 266264006365 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266264006366 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266264006367 NAD(P) binding site [chemical binding]; other site 266264006368 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266264006369 short chain dehydrogenase; Provisional; Region: PRK12828 266264006370 classical (c) SDRs; Region: SDR_c; cd05233 266264006371 NAD(P) binding site [chemical binding]; other site 266264006372 active site 266264006373 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 266264006374 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 266264006375 dimer interface [polypeptide binding]; other site 266264006376 active site 266264006377 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266264006378 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264006379 Isochorismatase family; Region: Isochorismatase; pfam00857 266264006380 catalytic triad [active] 266264006381 dimer interface [polypeptide binding]; other site 266264006382 conserved cis-peptide bond; other site 266264006383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264006384 active site 266264006385 dimerization interface [polypeptide binding]; other site 266264006386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264006387 DNA binding residues [nucleotide binding] 266264006388 dimerization interface [polypeptide binding]; other site 266264006389 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264006390 dimer interface [polypeptide binding]; other site 266264006391 catalytic triad [active] 266264006392 conserved cis-peptide bond; other site 266264006393 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 266264006394 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 266264006395 catalytic residues [active] 266264006396 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 266264006397 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 266264006398 Isochorismatase family; Region: Isochorismatase; pfam00857 266264006399 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264006400 catalytic triad [active] 266264006401 dimer interface [polypeptide binding]; other site 266264006402 conserved cis-peptide bond; other site 266264006403 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 266264006404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264006405 ligand binding site [chemical binding]; other site 266264006406 flexible hinge region; other site 266264006407 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266264006408 OsmC-like protein; Region: OsmC; cl00767 266264006409 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264006410 classical (c) SDRs; Region: SDR_c; cd05233 266264006411 NAD(P) binding site [chemical binding]; other site 266264006412 active site 266264006413 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266264006414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006415 putative substrate translocation pore; other site 266264006416 amidase; Provisional; Region: PRK07056 266264006417 Amidase; Region: Amidase; cl11426 266264006418 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 266264006419 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264006420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264006421 DNA-binding site [nucleotide binding]; DNA binding site 266264006422 FCD domain; Region: FCD; cl11656 266264006423 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264006424 Helix-turn-helix domains; Region: HTH; cl00088 266264006425 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264006426 allantoate amidohydrolase; Reviewed; Region: PRK12893 266264006427 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266264006428 active site 266264006429 metal binding site [ion binding]; metal-binding site 266264006430 dimer interface [polypeptide binding]; other site 266264006431 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 266264006432 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266264006433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266264006434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264006435 dimer interface [polypeptide binding]; other site 266264006436 conserved gate region; other site 266264006437 putative PBP binding loops; other site 266264006438 ABC-ATPase subunit interface; other site 266264006439 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 266264006440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264006441 dimer interface [polypeptide binding]; other site 266264006442 conserved gate region; other site 266264006443 putative PBP binding loops; other site 266264006444 ABC-ATPase subunit interface; other site 266264006445 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266264006446 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264006447 Walker A/P-loop; other site 266264006448 ATP binding site [chemical binding]; other site 266264006449 Q-loop/lid; other site 266264006450 ABC transporter signature motif; other site 266264006451 Walker B; other site 266264006452 D-loop; other site 266264006453 H-loop/switch region; other site 266264006454 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264006455 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264006456 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266264006457 Walker A/P-loop; other site 266264006458 ATP binding site [chemical binding]; other site 266264006459 Q-loop/lid; other site 266264006460 ABC transporter signature motif; other site 266264006461 Walker B; other site 266264006462 D-loop; other site 266264006463 H-loop/switch region; other site 266264006464 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264006465 Amidase; Region: Amidase; cl11426 266264006466 Cyclophilin-like; Region: Cyclophil_like; cl00950 266264006467 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264006468 Helix-turn-helix domains; Region: HTH; cl00088 266264006469 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264006470 dimerization interface [polypeptide binding]; other site 266264006471 substrate binding pocket [chemical binding]; other site 266264006472 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264006473 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266264006474 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264006475 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264006476 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264006477 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266264006478 active site lid residues [active] 266264006479 substrate binding pocket [chemical binding]; other site 266264006480 catalytic residues [active] 266264006481 substrate-Mg2+ binding site; other site 266264006482 aspartate-rich region 1; other site 266264006483 aspartate-rich region 2; other site 266264006484 allantoate amidohydrolase; Reviewed; Region: PRK12893 266264006485 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266264006486 active site 266264006487 metal binding site [ion binding]; metal-binding site 266264006488 dimer interface [polypeptide binding]; other site 266264006489 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266264006490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264006491 active site 266264006492 phosphorylation site [posttranslational modification] 266264006493 intermolecular recognition site; other site 266264006494 dimerization interface [polypeptide binding]; other site 266264006495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264006496 DNA binding site [nucleotide binding] 266264006497 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 266264006498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264006499 dimerization interface [polypeptide binding]; other site 266264006500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264006501 ATP binding site [chemical binding]; other site 266264006502 Mg2+ binding site [ion binding]; other site 266264006503 G-X-G motif; other site 266264006504 citrate-proton symporter; Provisional; Region: PRK15075 266264006505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006506 putative substrate translocation pore; other site 266264006507 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266264006508 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 266264006509 dimer interface [polypeptide binding]; other site 266264006510 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266264006511 catalytic triad [active] 266264006512 peroxidatic and resolving cysteines [active] 266264006513 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 266264006514 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264006515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264006516 Coenzyme A binding pocket [chemical binding]; other site 266264006517 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 266264006518 homotrimer interaction site [polypeptide binding]; other site 266264006519 zinc binding site [ion binding]; other site 266264006520 CDP-binding sites; other site 266264006521 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 266264006522 substrate binding site; other site 266264006523 dimer interface; other site 266264006524 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 266264006525 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 266264006526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264006527 ATP binding site [chemical binding]; other site 266264006528 putative Mg++ binding site [ion binding]; other site 266264006529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264006530 nucleotide binding region [chemical binding]; other site 266264006531 ATP-binding site [chemical binding]; other site 266264006532 TRCF domain; Region: TRCF; cl04088 266264006533 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 266264006534 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 266264006535 metal binding site [ion binding]; metal-binding site 266264006536 putative dimer interface [polypeptide binding]; other site 266264006537 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 266264006538 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266264006539 OsmC-like protein; Region: OsmC; cl00767 266264006540 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 266264006541 Clp amino terminal domain; Region: Clp_N; pfam02861 266264006542 Clp amino terminal domain; Region: Clp_N; pfam02861 266264006543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006544 Walker A motif; other site 266264006545 ATP binding site [chemical binding]; other site 266264006546 Walker B motif; other site 266264006547 arginine finger; other site 266264006548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006549 Walker A motif; other site 266264006550 ATP binding site [chemical binding]; other site 266264006551 Walker B motif; other site 266264006552 arginine finger; other site 266264006553 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 266264006554 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 266264006555 CrcB-like protein; Region: CRCB; cl09114 266264006556 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 266264006557 MoaE homodimer interface [polypeptide binding]; other site 266264006558 MoaD interaction [polypeptide binding]; other site 266264006559 active site residues [active] 266264006560 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 266264006561 MoaE interaction surface [polypeptide binding]; other site 266264006562 MoeB interaction surface [polypeptide binding]; other site 266264006563 thiocarboxylated glycine; other site 266264006564 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266264006565 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266264006566 dimer interface [polypeptide binding]; other site 266264006567 putative functional site; other site 266264006568 putative MPT binding site; other site 266264006569 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 266264006570 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 266264006571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264006572 catalytic residue [active] 266264006573 homoserine dehydrogenase; Provisional; Region: PRK06349 266264006574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264006575 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 266264006576 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 266264006577 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 266264006578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264006579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264006580 homodimer interface [polypeptide binding]; other site 266264006581 catalytic residue [active] 266264006582 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 266264006583 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 266264006584 catalytic triad [active] 266264006585 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 266264006586 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 266264006587 putative active site [active] 266264006588 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264006589 NlpC/P60 family; Region: NLPC_P60; cl11438 266264006590 Phosphate transporter family; Region: PHO4; cl00396 266264006591 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 266264006592 replicative DNA helicase; Provisional; Region: PRK07004 266264006593 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 266264006594 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 266264006595 Walker A motif; other site 266264006596 ATP binding site [chemical binding]; other site 266264006597 Walker B motif; other site 266264006598 DNA binding loops [nucleotide binding] 266264006599 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 266264006600 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 266264006601 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 266264006602 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 266264006603 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 266264006604 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 266264006605 active site 266264006606 homotetramer interface [polypeptide binding]; other site 266264006607 homodimer interface [polypeptide binding]; other site 266264006608 LexA repressor; Validated; Region: PRK00215 266264006609 Helix-turn-helix domains; Region: HTH; cl00088 266264006610 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266264006611 Catalytic site [active] 266264006612 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 266264006613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264006614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264006615 homodimer interface [polypeptide binding]; other site 266264006616 catalytic residue [active] 266264006617 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 266264006618 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 266264006619 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266264006620 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266264006621 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 266264006622 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 266264006623 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 266264006624 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266264006625 FMN binding site [chemical binding]; other site 266264006626 active site 266264006627 catalytic residues [active] 266264006628 substrate binding site [chemical binding]; other site 266264006629 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264006630 Helix-turn-helix domains; Region: HTH; cl00088 266264006631 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 266264006632 HTH-like domain; Region: HTH_21; pfam13276 266264006633 Integrase core domain; Region: rve; cl01316 266264006634 Integrase core domain; Region: rve_3; cl15866 266264006635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264006636 Phosphate-starvation-inducible E; Region: PsiE; cl01264 266264006637 tyrosine-based site-specific recombinase (fragment) 266264006638 AAA domain; Region: AAA_22; pfam13401 266264006639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006640 Walker A motif; other site 266264006641 ATP binding site [chemical binding]; other site 266264006642 Walker B motif; other site 266264006643 arginine finger; other site 266264006644 Integrase core domain; Region: rve; cl01316 266264006645 tyrosine-based site-specific recombinase(fragment) 266264006646 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264006647 Integrase core domain; Region: rve; cl01316 266264006648 AAA domain; Region: AAA_22; pfam13401 266264006649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006650 Walker A motif; other site 266264006651 ATP binding site [chemical binding]; other site 266264006652 Walker B motif; other site 266264006653 arginine finger; other site 266264006654 phage head/capsid major protein(fragment) 266264006655 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 266264006656 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264006657 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 266264006658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264006659 substrate binding site [chemical binding]; other site 266264006660 oxyanion hole (OAH) forming residues; other site 266264006661 trimer interface [polypeptide binding]; other site 266264006662 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266264006663 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266264006664 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 266264006665 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 266264006666 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 266264006667 G1 box; other site 266264006668 putative GEF interaction site [polypeptide binding]; other site 266264006669 GTP/Mg2+ binding site [chemical binding]; other site 266264006670 Switch I region; other site 266264006671 G2 box; other site 266264006672 G3 box; other site 266264006673 Switch II region; other site 266264006674 G4 box; other site 266264006675 G5 box; other site 266264006676 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 266264006677 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 266264006678 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264006679 Helix-turn-helix domains; Region: HTH; cl00088 266264006680 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264006681 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 266264006682 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264006683 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264006684 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264006685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006686 putative substrate translocation pore; other site 266264006687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006688 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 266264006689 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 266264006690 RNA binding site [nucleotide binding]; other site 266264006691 active site 266264006692 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 266264006693 Ribosome-binding factor A; Region: RBFA; cl00542 266264006694 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266264006695 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 266264006696 translation initiation factor IF-2; Region: IF-2; TIGR00487 266264006697 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266264006698 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 266264006699 G1 box; other site 266264006700 putative GEF interaction site [polypeptide binding]; other site 266264006701 GTP/Mg2+ binding site [chemical binding]; other site 266264006702 Switch I region; other site 266264006703 G2 box; other site 266264006704 G3 box; other site 266264006705 Switch II region; other site 266264006706 G4 box; other site 266264006707 G5 box; other site 266264006708 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 266264006709 Translation-initiation factor 2; Region: IF-2; pfam11987 266264006710 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 266264006711 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 266264006712 NusA N-terminal domain; Region: NusA_N; pfam08529 266264006713 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 266264006714 RNA binding site [nucleotide binding]; other site 266264006715 homodimer interface [polypeptide binding]; other site 266264006716 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 266264006717 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266264006718 G-X-X-G motif; other site 266264006719 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 266264006720 ribosome maturation protein RimP; Reviewed; Region: PRK00092 266264006721 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 266264006722 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 266264006723 Sm1 motif; other site 266264006724 predicted subunit interaction site [polypeptide binding]; other site 266264006725 RNA binding pocket [nucleotide binding]; other site 266264006726 Sm2 motif; other site 266264006727 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266264006728 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264006729 RNA binding surface [nucleotide binding]; other site 266264006730 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 266264006731 probable active site [active] 266264006732 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 266264006733 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266264006734 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 266264006735 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264006736 ligand binding site [chemical binding]; other site 266264006737 flexible hinge region; other site 266264006738 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264006739 putative switch regulator; other site 266264006740 non-specific DNA interactions [nucleotide binding]; other site 266264006741 DNA binding site [nucleotide binding] 266264006742 sequence specific DNA binding site [nucleotide binding]; other site 266264006743 putative cAMP binding site [chemical binding]; other site 266264006744 FixH; Region: FixH; cl01254 266264006745 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 266264006746 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266264006747 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 266264006748 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 266264006749 Cytochrome c; Region: Cytochrom_C; cl11414 266264006750 Cytochrome c; Region: Cytochrom_C; cl11414 266264006751 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 266264006752 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 266264006753 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 266264006754 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 266264006755 Low-spin heme binding site [chemical binding]; other site 266264006756 Putative water exit pathway; other site 266264006757 Binuclear center (active site) [active] 266264006758 Putative proton exit pathway; other site 266264006759 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 266264006760 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 266264006761 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264006762 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 266264006763 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264006764 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264006765 Predicted ATPase [General function prediction only]; Region: COG1485 266264006766 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 266264006767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264006768 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264006769 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 266264006770 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264006771 E3 interaction surface; other site 266264006772 lipoyl attachment site [posttranslational modification]; other site 266264006773 e3 binding domain; Region: E3_binding; pfam02817 266264006774 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 266264006775 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 266264006776 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 266264006777 TPP-binding site [chemical binding]; other site 266264006778 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 266264006779 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 266264006780 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 266264006781 putative active site [active] 266264006782 catalytic site [active] 266264006783 putative metal binding site [ion binding]; other site 266264006784 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266264006785 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266264006786 Walker A/P-loop; other site 266264006787 ATP binding site [chemical binding]; other site 266264006788 Q-loop/lid; other site 266264006789 ABC transporter signature motif; other site 266264006790 Walker B; other site 266264006791 D-loop; other site 266264006792 H-loop/switch region; other site 266264006793 TOBE domain; Region: TOBE_2; cl01440 266264006794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266264006795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264006796 dimer interface [polypeptide binding]; other site 266264006797 conserved gate region; other site 266264006798 putative PBP binding loops; other site 266264006799 ABC-ATPase subunit interface; other site 266264006800 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266264006801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266264006802 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266264006803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264006804 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 266264006805 Peptidase M30; Region: Peptidase_M30; pfam10460 266264006806 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 266264006807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264006808 active site 266264006809 phosphorylation site [posttranslational modification] 266264006810 intermolecular recognition site; other site 266264006811 dimerization interface [polypeptide binding]; other site 266264006812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006813 Walker A motif; other site 266264006814 ATP binding site [chemical binding]; other site 266264006815 Walker B motif; other site 266264006816 arginine finger; other site 266264006817 Helix-turn-helix domains; Region: HTH; cl00088 266264006818 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266264006819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264006820 dimer interface [polypeptide binding]; other site 266264006821 phosphorylation site [posttranslational modification] 266264006822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264006823 ATP binding site [chemical binding]; other site 266264006824 Mg2+ binding site [ion binding]; other site 266264006825 G-X-G motif; other site 266264006826 glutamine synthetase; Provisional; Region: glnA; PRK09469 266264006827 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266264006828 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266264006829 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 266264006830 active site residue [active] 266264006831 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 266264006832 putative MPT binding site; other site 266264006833 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 266264006834 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266264006835 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 266264006836 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 266264006837 NodB motif; other site 266264006838 active site 266264006839 catalytic site [active] 266264006840 metal binding site [ion binding]; metal-binding site 266264006841 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 266264006842 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266264006843 structural tetrad; other site 266264006844 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266264006845 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 266264006846 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264006847 ATP binding site [chemical binding]; other site 266264006848 putative Mg++ binding site [ion binding]; other site 266264006849 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264006850 Helicase associated domain (HA2); Region: HA2; cl04503 266264006851 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 266264006852 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 266264006853 N-acetylglutamate synthase; Validated; Region: PRK05279 266264006854 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 266264006855 putative feedback inhibition sensing region; other site 266264006856 putative nucleotide binding site [chemical binding]; other site 266264006857 putative substrate binding site [chemical binding]; other site 266264006858 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264006859 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 266264006860 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 266264006861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006862 putative substrate translocation pore; other site 266264006863 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 266264006864 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 266264006865 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 266264006866 [4Fe-4S] binding site [ion binding]; other site 266264006867 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266264006868 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266264006869 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266264006870 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 266264006871 molybdopterin cofactor binding site; other site 266264006872 nitrate reductase, beta subunit; Region: narH; TIGR01660 266264006873 4Fe-4S binding domain; Region: Fer4; cl02805 266264006874 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 266264006875 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 266264006876 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 266264006877 active site clefts [active] 266264006878 zinc binding site [ion binding]; other site 266264006879 dimer interface [polypeptide binding]; other site 266264006880 Cytochrome c; Region: Cytochrom_C; cl11414 266264006881 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 266264006882 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266264006883 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264006884 Helix-turn-helix domains; Region: HTH; cl00088 266264006885 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264006886 Helix-turn-helix domains; Region: HTH; cl00088 266264006887 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 266264006888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 266264006889 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264006890 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264006891 FMN binding site [chemical binding]; other site 266264006892 substrate binding site [chemical binding]; other site 266264006893 putative catalytic residue [active] 266264006894 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 266264006895 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 266264006896 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 266264006897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264006898 dimerization interface [polypeptide binding]; other site 266264006899 GAF domain; Region: GAF; cl15785 266264006900 Histidine kinase; Region: HisKA_3; pfam07730 266264006901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264006902 ATP binding site [chemical binding]; other site 266264006903 Mg2+ binding site [ion binding]; other site 266264006904 G-X-G motif; other site 266264006905 transcriptional regulator NarL; Provisional; Region: PRK10651 266264006906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264006907 active site 266264006908 phosphorylation site [posttranslational modification] 266264006909 intermolecular recognition site; other site 266264006910 dimerization interface [polypeptide binding]; other site 266264006911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264006912 DNA binding residues [nucleotide binding] 266264006913 dimerization interface [polypeptide binding]; other site 266264006914 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 266264006915 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266264006916 active site 266264006917 dimer interface [polypeptide binding]; other site 266264006918 transaldolase-like protein; Provisional; Region: PTZ00411 266264006919 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 266264006920 active site 266264006921 dimer interface [polypeptide binding]; other site 266264006922 catalytic residue [active] 266264006923 NAD-dependent deacetylase; Provisional; Region: PRK00481 266264006924 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 266264006925 NAD+ binding site [chemical binding]; other site 266264006926 substrate binding site [chemical binding]; other site 266264006927 Zn binding site [ion binding]; other site 266264006928 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 266264006929 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 266264006930 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 266264006931 ribonuclease R; Region: RNase_R; TIGR02063 266264006932 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266264006933 RNB domain; Region: RNB; pfam00773 266264006934 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 266264006935 RNA binding site [nucleotide binding]; other site 266264006936 Predicted transcriptional regulator [Transcription]; Region: COG1959 266264006937 Helix-turn-helix domains; Region: HTH; cl00088 266264006938 Helix-turn-helix domains; Region: HTH; cl00088 266264006939 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 266264006940 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266264006941 NAD binding site [chemical binding]; other site 266264006942 putative active site [active] 266264006943 substrate binding site [chemical binding]; other site 266264006944 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264006945 active site 266264006946 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 266264006947 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 266264006948 GDP-binding site [chemical binding]; other site 266264006949 ACT binding site; other site 266264006950 IMP binding site; other site 266264006951 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 266264006952 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 266264006953 dimer interface [polypeptide binding]; other site 266264006954 motif 1; other site 266264006955 active site 266264006956 motif 2; other site 266264006957 motif 3; other site 266264006958 HflC protein; Region: hflC; TIGR01932 266264006959 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 266264006960 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 266264006961 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 266264006962 HflK protein; Region: hflK; TIGR01933 266264006963 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 266264006964 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 266264006965 HflX GTPase family; Region: HflX; cd01878 266264006966 G1 box; other site 266264006967 GTP/Mg2+ binding site [chemical binding]; other site 266264006968 Switch I region; other site 266264006969 G2 box; other site 266264006970 G3 box; other site 266264006971 Switch II region; other site 266264006972 G4 box; other site 266264006973 G5 box; other site 266264006974 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 266264006975 Sm1 motif; other site 266264006976 intra - hexamer interaction site; other site 266264006977 inter - hexamer interaction site [polypeptide binding]; other site 266264006978 nucleotide binding pocket [chemical binding]; other site 266264006979 Sm2 motif; other site 266264006980 GTP-binding protein Der; Reviewed; Region: PRK00093 266264006981 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 266264006982 G1 box; other site 266264006983 GTP/Mg2+ binding site [chemical binding]; other site 266264006984 Switch I region; other site 266264006985 G2 box; other site 266264006986 Switch II region; other site 266264006987 G3 box; other site 266264006988 G4 box; other site 266264006989 G5 box; other site 266264006990 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 266264006991 G1 box; other site 266264006992 GTP/Mg2+ binding site [chemical binding]; other site 266264006993 Switch I region; other site 266264006994 G2 box; other site 266264006995 G3 box; other site 266264006996 Switch II region; other site 266264006997 G4 box; other site 266264006998 G5 box; other site 266264006999 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 266264007000 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 266264007001 Trp docking motif [polypeptide binding]; other site 266264007002 active site 266264007003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 266264007004 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 266264007005 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 266264007006 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 266264007007 dimer interface [polypeptide binding]; other site 266264007008 motif 1; other site 266264007009 active site 266264007010 motif 2; other site 266264007011 motif 3; other site 266264007012 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 266264007013 anticodon binding site; other site 266264007014 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 266264007015 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266264007016 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266264007017 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 266264007018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264007019 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 266264007020 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 266264007021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264007022 binding surface 266264007023 TPR motif; other site 266264007024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264007025 binding surface 266264007026 TPR motif; other site 266264007027 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 266264007028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264007029 FeS/SAM binding site; other site 266264007030 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 266264007031 active site 266264007032 multimer interface [polypeptide binding]; other site 266264007033 YccA-like proteins; Region: YccA_like; cd10433 266264007034 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 266264007035 TRAM domain; Region: TRAM; cl01282 266264007036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264007037 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266264007038 putative catalytic site [active] 266264007039 putative metal binding site [ion binding]; other site 266264007040 putative phosphate binding site [ion binding]; other site 266264007041 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 266264007042 active site 266264007043 catalytic site [active] 266264007044 substrate binding site [chemical binding]; other site 266264007045 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 266264007046 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 266264007047 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266264007048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264007049 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266264007050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264007051 DNA binding residues [nucleotide binding] 266264007052 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264007053 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 266264007054 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 266264007055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264007056 S-adenosylmethionine binding site [chemical binding]; other site 266264007057 Survival protein SurE; Region: SurE; cl00448 266264007058 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266264007059 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 266264007060 NAD(P) binding site [chemical binding]; other site 266264007061 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264007062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007063 dimer interface [polypeptide binding]; other site 266264007064 conserved gate region; other site 266264007065 putative PBP binding loops; other site 266264007066 ABC-ATPase subunit interface; other site 266264007067 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264007068 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266264007069 Walker A/P-loop; other site 266264007070 ATP binding site [chemical binding]; other site 266264007071 Q-loop/lid; other site 266264007072 ABC transporter signature motif; other site 266264007073 Walker B; other site 266264007074 D-loop; other site 266264007075 H-loop/switch region; other site 266264007076 NMT1-like family; Region: NMT1_2; cl15260 266264007077 NMT1/THI5 like; Region: NMT1; pfam09084 266264007078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264007079 NMT1-like family; Region: NMT1_2; cl15260 266264007080 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 266264007081 active site 266264007082 catalytic residues [active] 266264007083 metal binding site [ion binding]; metal-binding site 266264007084 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264007085 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264007086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264007087 Helix-turn-helix domains; Region: HTH; cl00088 266264007088 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264007089 putative dimerization interface [polypeptide binding]; other site 266264007090 recombination protein RecR; Reviewed; Region: recR; PRK00076 266264007091 RecR protein; Region: RecR; pfam02132 266264007092 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 266264007093 putative active site [active] 266264007094 putative metal-binding site [ion binding]; other site 266264007095 tetramer interface [polypeptide binding]; other site 266264007096 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 266264007097 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 266264007098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007099 Walker A motif; other site 266264007100 ATP binding site [chemical binding]; other site 266264007101 Walker B motif; other site 266264007102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264007103 arginine finger; other site 266264007104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 266264007105 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 266264007106 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 266264007107 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 266264007108 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 266264007109 active site 266264007110 dimer interface [polypeptide binding]; other site 266264007111 effector binding site; other site 266264007112 Cys-rich peptide, TIGR04165 family; Region: methano_modCys 266264007113 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 266264007114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264007115 Family description; Region: UvrD_C_2; cl15862 266264007116 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 266264007117 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 266264007118 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266264007119 catalytic residues [active] 266264007120 transcription termination factor Rho; Provisional; Region: rho; PRK09376 266264007121 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 266264007122 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 266264007123 RNA binding site [nucleotide binding]; other site 266264007124 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 266264007125 multimer interface [polypeptide binding]; other site 266264007126 Walker A motif; other site 266264007127 ATP binding site [chemical binding]; other site 266264007128 Walker B motif; other site 266264007129 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 266264007130 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 266264007131 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266264007132 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 266264007133 multidrug efflux protein; Reviewed; Region: PRK01766 266264007134 MatE; Region: MatE; cl10513 266264007135 MatE; Region: MatE; cl10513 266264007136 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 266264007137 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266264007138 HIGH motif; other site 266264007139 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266264007140 active site 266264007141 KMSKS motif; other site 266264007142 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 266264007143 nucleophile elbow; other site 266264007144 NlpC/P60 family; Region: NLPC_P60; cl11438 266264007145 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266264007146 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264007147 Walker A/P-loop; other site 266264007148 ATP binding site [chemical binding]; other site 266264007149 Q-loop/lid; other site 266264007150 ABC transporter signature motif; other site 266264007151 Walker B; other site 266264007152 D-loop; other site 266264007153 H-loop/switch region; other site 266264007154 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264007155 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264007156 Walker A/P-loop; other site 266264007157 ATP binding site [chemical binding]; other site 266264007158 Q-loop/lid; other site 266264007159 ABC transporter signature motif; other site 266264007160 Walker B; other site 266264007161 D-loop; other site 266264007162 H-loop/switch region; other site 266264007163 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 266264007164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007165 dimer interface [polypeptide binding]; other site 266264007166 conserved gate region; other site 266264007167 putative PBP binding loops; other site 266264007168 ABC-ATPase subunit interface; other site 266264007169 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 266264007170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007171 dimer interface [polypeptide binding]; other site 266264007172 conserved gate region; other site 266264007173 putative PBP binding loops; other site 266264007174 ABC-ATPase subunit interface; other site 266264007175 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266264007176 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266264007177 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266264007178 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 266264007179 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266264007180 NAD binding site [chemical binding]; other site 266264007181 homotetramer interface [polypeptide binding]; other site 266264007182 homodimer interface [polypeptide binding]; other site 266264007183 substrate binding site [chemical binding]; other site 266264007184 active site 266264007185 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264007186 Helix-turn-helix domains; Region: HTH; cl00088 266264007187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264007188 dimerization interface [polypeptide binding]; other site 266264007189 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 266264007190 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264007191 SCP-2 sterol transfer family; Region: SCP2; cl01225 266264007192 flagellin; Validated; Region: PRK08026 266264007193 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266264007194 flagellin; Validated; Region: PRK08026 266264007195 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266264007196 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266264007197 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266264007198 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264007199 Transglycosylase; Region: Transgly; cl07896 266264007200 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264007201 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264007202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264007203 active site 266264007204 phosphorylation site [posttranslational modification] 266264007205 intermolecular recognition site; other site 266264007206 dimerization interface [polypeptide binding]; other site 266264007207 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264007208 DNA binding residues [nucleotide binding] 266264007209 dimerization interface [polypeptide binding]; other site 266264007210 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264007211 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264007212 substrate binding pocket [chemical binding]; other site 266264007213 membrane-bound complex binding site; other site 266264007214 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264007215 hinge residues; other site 266264007216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264007217 dimer interface [polypeptide binding]; other site 266264007218 phosphorylation site [posttranslational modification] 266264007219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264007220 ATP binding site [chemical binding]; other site 266264007221 Mg2+ binding site [ion binding]; other site 266264007222 G-X-G motif; other site 266264007223 Response regulator receiver domain; Region: Response_reg; pfam00072 266264007224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264007225 active site 266264007226 phosphorylation site [posttranslational modification] 266264007227 intermolecular recognition site; other site 266264007228 dimerization interface [polypeptide binding]; other site 266264007229 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264007230 Cytochrome c; Region: Cytochrom_C; cl11414 266264007231 Cytochrome c [Energy production and conversion]; Region: COG3258 266264007232 Cytochrome c; Region: Cytochrom_C; cl11414 266264007233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264007234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264007235 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 266264007236 5' RNA guide strand anchoring site; other site 266264007237 active site 266264007238 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 266264007239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264007240 non-specific DNA binding site [nucleotide binding]; other site 266264007241 salt bridge; other site 266264007242 sequence-specific DNA binding site [nucleotide binding]; other site 266264007243 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 266264007244 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 266264007245 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266264007246 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266264007247 active site 266264007248 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264007249 active site 266264007250 catalytic residues [active] 266264007251 DNA binding site [nucleotide binding] 266264007252 Int/Topo IB signature motif; other site 266264007253 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264007254 metal binding site [ion binding]; metal-binding site 266264007255 active site 266264007256 I-site; other site 266264007257 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266264007258 rRNA binding site [nucleotide binding]; other site 266264007259 predicted 30S ribosome binding site; other site 266264007260 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264007261 catalytic core [active] 266264007262 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264007263 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 266264007264 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 266264007265 polyphosphate kinase; Provisional; Region: PRK05443 266264007266 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 266264007267 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 266264007268 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266264007269 putative active site [active] 266264007270 catalytic site [active] 266264007271 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 266264007272 putative domain interface [polypeptide binding]; other site 266264007273 putative active site [active] 266264007274 catalytic site [active] 266264007275 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266264007276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264007277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264007278 dimer interface [polypeptide binding]; other site 266264007279 phosphorylation site [posttranslational modification] 266264007280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264007281 ATP binding site [chemical binding]; other site 266264007282 Mg2+ binding site [ion binding]; other site 266264007283 G-X-G motif; other site 266264007284 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 266264007285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264007286 active site 266264007287 phosphorylation site [posttranslational modification] 266264007288 intermolecular recognition site; other site 266264007289 dimerization interface [polypeptide binding]; other site 266264007290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264007291 DNA binding site [nucleotide binding] 266264007292 transcriptional regulator PhoU; Provisional; Region: PRK11115 266264007293 PhoU domain; Region: PhoU; pfam01895 266264007294 PhoU domain; Region: PhoU; pfam01895 266264007295 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 266264007296 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 266264007297 Walker A/P-loop; other site 266264007298 ATP binding site [chemical binding]; other site 266264007299 Q-loop/lid; other site 266264007300 ABC transporter signature motif; other site 266264007301 Walker B; other site 266264007302 D-loop; other site 266264007303 H-loop/switch region; other site 266264007304 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 266264007305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007306 dimer interface [polypeptide binding]; other site 266264007307 conserved gate region; other site 266264007308 putative PBP binding loops; other site 266264007309 ABC-ATPase subunit interface; other site 266264007310 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 266264007311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007312 dimer interface [polypeptide binding]; other site 266264007313 conserved gate region; other site 266264007314 putative PBP binding loops; other site 266264007315 ABC-ATPase subunit interface; other site 266264007316 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264007317 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 266264007318 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 266264007319 active site 266264007320 substrate binding site [chemical binding]; other site 266264007321 metal binding site [ion binding]; metal-binding site 266264007322 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 266264007323 dihydropteroate synthase; Region: DHPS; TIGR01496 266264007324 substrate binding pocket [chemical binding]; other site 266264007325 dimer interface [polypeptide binding]; other site 266264007326 inhibitor binding site; inhibition site 266264007327 FtsH Extracellular; Region: FtsH_ext; pfam06480 266264007328 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266264007329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007330 Walker A motif; other site 266264007331 ATP binding site [chemical binding]; other site 266264007332 Walker B motif; other site 266264007333 arginine finger; other site 266264007334 Peptidase family M41; Region: Peptidase_M41; pfam01434 266264007335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264007336 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 266264007337 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 266264007338 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 266264007339 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 266264007340 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266264007341 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266264007342 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 266264007343 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264007344 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264007345 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 266264007346 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264007347 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264007348 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 266264007349 IMP binding site; other site 266264007350 dimer interface [polypeptide binding]; other site 266264007351 interdomain contacts; other site 266264007352 partial ornithine binding site; other site 266264007353 LysE type translocator; Region: LysE; cl00565 266264007354 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 266264007355 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 266264007356 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 266264007357 catalytic site [active] 266264007358 subunit interface [polypeptide binding]; other site 266264007359 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264007360 homotrimer interaction site [polypeptide binding]; other site 266264007361 putative active site [active] 266264007362 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264007363 active site 266264007364 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266264007365 AMP-binding enzyme; Region: AMP-binding; cl15778 266264007366 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264007367 isovaleryl-CoA dehydrogenase; Region: PLN02519 266264007368 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264007369 active site 266264007370 enoyl-CoA hydratase; Provisional; Region: PRK06688 266264007371 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264007372 substrate binding site [chemical binding]; other site 266264007373 oxyanion hole (OAH) forming residues; other site 266264007374 trimer interface [polypeptide binding]; other site 266264007375 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264007376 classical (c) SDRs; Region: SDR_c; cd05233 266264007377 NAD(P) binding site [chemical binding]; other site 266264007378 active site 266264007379 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 266264007380 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266264007381 active site 266264007382 FMN binding site [chemical binding]; other site 266264007383 substrate binding site [chemical binding]; other site 266264007384 homotetramer interface [polypeptide binding]; other site 266264007385 catalytic residue [active] 266264007386 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 266264007387 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 266264007388 AMP-binding enzyme; Region: AMP-binding; cl15778 266264007389 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264007390 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266264007391 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 266264007392 putative active site [active] 266264007393 catalytic site [active] 266264007394 putative metal binding site [ion binding]; other site 266264007395 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266264007396 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264007397 catalytic residue [active] 266264007398 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264007399 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264007400 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 266264007401 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264007402 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266264007403 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266264007404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264007405 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 266264007406 RNA/DNA hybrid binding site [nucleotide binding]; other site 266264007407 active site 266264007408 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 266264007409 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 266264007410 active site 266264007411 catalytic site [active] 266264007412 substrate binding site [chemical binding]; other site 266264007413 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 266264007414 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 266264007415 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264007416 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266264007417 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264007418 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266264007419 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264007420 Ligand Binding Site [chemical binding]; other site 266264007421 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264007422 Ligand Binding Site [chemical binding]; other site 266264007423 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 266264007424 putative FMN binding site [chemical binding]; other site 266264007425 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 266264007426 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 266264007427 active site residue [active] 266264007428 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 266264007429 active site residue [active] 266264007430 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 266264007431 active site residue [active] 266264007432 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 266264007433 active site residue [active] 266264007434 Cysteine dioxygenase type I; Region: CDO_I; cl15835 266264007435 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264007436 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264007437 active site 266264007438 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266264007439 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 266264007440 dimer interface [polypeptide binding]; other site 266264007441 active site 266264007442 non-prolyl cis peptide bond; other site 266264007443 insertion regions; other site 266264007444 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266264007445 NMT1-like family; Region: NMT1_2; cl15260 266264007446 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264007447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007448 dimer interface [polypeptide binding]; other site 266264007449 conserved gate region; other site 266264007450 putative PBP binding loops; other site 266264007451 ABC-ATPase subunit interface; other site 266264007452 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264007453 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266264007454 Walker A/P-loop; other site 266264007455 ATP binding site [chemical binding]; other site 266264007456 Q-loop/lid; other site 266264007457 ABC transporter signature motif; other site 266264007458 Walker B; other site 266264007459 D-loop; other site 266264007460 H-loop/switch region; other site 266264007461 Cytochrome c; Region: Cytochrom_C; cl11414 266264007462 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266264007463 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266264007464 putative active site [active] 266264007465 Isochorismatase family; Region: Isochorismatase; pfam00857 266264007466 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 266264007467 catalytic triad [active] 266264007468 conserved cis-peptide bond; other site 266264007469 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264007470 Helix-turn-helix domains; Region: HTH; cl00088 266264007471 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264007472 dimerization interface [polypeptide binding]; other site 266264007473 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264007474 PAS domain S-box; Region: sensory_box; TIGR00229 266264007475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264007476 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264007477 metal binding site [ion binding]; metal-binding site 266264007478 active site 266264007479 I-site; other site 266264007480 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266264007481 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264007482 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 266264007483 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266264007484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007485 dimer interface [polypeptide binding]; other site 266264007486 conserved gate region; other site 266264007487 putative PBP binding loops; other site 266264007488 ABC-ATPase subunit interface; other site 266264007489 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266264007490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007491 dimer interface [polypeptide binding]; other site 266264007492 conserved gate region; other site 266264007493 putative PBP binding loops; other site 266264007494 ABC-ATPase subunit interface; other site 266264007495 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266264007496 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 266264007497 Walker A/P-loop; other site 266264007498 ATP binding site [chemical binding]; other site 266264007499 Q-loop/lid; other site 266264007500 ABC transporter signature motif; other site 266264007501 Walker B; other site 266264007502 D-loop; other site 266264007503 H-loop/switch region; other site 266264007504 TOBE domain; Region: TOBE_2; cl01440 266264007505 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266264007506 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264007507 Walker A/P-loop; other site 266264007508 ATP binding site [chemical binding]; other site 266264007509 Q-loop/lid; other site 266264007510 ABC transporter signature motif; other site 266264007511 Walker B; other site 266264007512 D-loop; other site 266264007513 H-loop/switch region; other site 266264007514 TOBE domain; Region: TOBE_2; cl01440 266264007515 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 266264007516 Helix-turn-helix domains; Region: HTH; cl00088 266264007517 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264007518 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 266264007519 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 266264007520 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 266264007521 putative active site [active] 266264007522 putative substrate binding site [chemical binding]; other site 266264007523 putative cosubstrate binding site; other site 266264007524 catalytic site [active] 266264007525 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 266264007526 nudix motif; other site 266264007527 glycerol kinase; Provisional; Region: glpK; PRK00047 266264007528 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 266264007529 N- and C-terminal domain interface [polypeptide binding]; other site 266264007530 active site 266264007531 MgATP binding site [chemical binding]; other site 266264007532 catalytic site [active] 266264007533 metal binding site [ion binding]; metal-binding site 266264007534 glycerol binding site [chemical binding]; other site 266264007535 homotetramer interface [polypeptide binding]; other site 266264007536 homodimer interface [polypeptide binding]; other site 266264007537 FBP binding site [chemical binding]; other site 266264007538 protein IIAGlc interface [polypeptide binding]; other site 266264007539 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 266264007540 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 266264007541 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 266264007542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264007543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264007544 metal binding site [ion binding]; metal-binding site 266264007545 active site 266264007546 I-site; other site 266264007547 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264007548 ligand binding site [chemical binding]; other site 266264007549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264007550 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 266264007551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264007552 putative active site [active] 266264007553 heme pocket [chemical binding]; other site 266264007554 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264007555 metal binding site [ion binding]; metal-binding site 266264007556 active site 266264007557 I-site; other site 266264007558 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264007559 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 266264007560 homodimer interface [polypeptide binding]; other site 266264007561 substrate-cofactor binding pocket; other site 266264007562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264007563 catalytic residue [active] 266264007564 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 266264007565 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 266264007566 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 266264007567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264007568 binding surface 266264007569 TPR motif; other site 266264007570 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 266264007571 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 266264007572 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 266264007573 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 266264007574 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 266264007575 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266264007576 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 266264007577 DXD motif; other site 266264007578 PilZ domain; Region: PilZ; cl01260 266264007579 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 266264007580 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 266264007581 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 266264007582 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 266264007583 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264007584 metal binding site [ion binding]; metal-binding site 266264007585 active site 266264007586 I-site; other site 266264007587 DNA packaging protein UL33; Provisional; Region: PHA03236 266264007588 flagellar capping protein; Reviewed; Region: fliD; PRK08032 266264007589 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 266264007590 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 266264007591 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266264007592 MULE transposase domain; Region: MULE; pfam10551 266264007593 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 266264007594 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266264007595 Na binding site [ion binding]; other site 266264007596 acetyl-CoA synthetase; Provisional; Region: PRK00174 266264007597 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 266264007598 AMP-binding enzyme; Region: AMP-binding; cl15778 266264007599 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264007600 EamA-like transporter family; Region: EamA; cl01037 266264007601 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 266264007602 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 266264007603 Fumarase C-terminus; Region: Fumerase_C; cl00795 266264007604 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266264007605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007606 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 266264007607 Walker A motif; other site 266264007608 ATP binding site [chemical binding]; other site 266264007609 Walker B motif; other site 266264007610 arginine finger; other site 266264007611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007612 Walker A motif; other site 266264007613 ATP binding site [chemical binding]; other site 266264007614 Walker B motif; other site 266264007615 arginine finger; other site 266264007616 Gram-negative bacterial tonB protein; Region: TonB; cl10048 266264007617 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266264007618 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 266264007619 Hemin uptake protein hemP; Region: hemP; cl10043 266264007620 Domain of unknown function (DUF336); Region: DUF336; cl01249 266264007621 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 266264007622 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 266264007623 Helix-turn-helix domains; Region: HTH; cl00088 266264007624 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 266264007625 putative dimerization interface [polypeptide binding]; other site 266264007626 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266264007627 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266264007628 Domain of unknown function (DUF305); Region: DUF305; cl15795 266264007629 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264007630 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266264007631 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264007632 Magnesium ion binding site [ion binding]; other site 266264007633 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 266264007634 ParB-like nuclease domain; Region: ParBc; cl02129 266264007635 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 266264007636 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 266264007637 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 266264007638 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266264007639 dimer interface [polypeptide binding]; other site 266264007640 ssDNA binding site [nucleotide binding]; other site 266264007641 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266264007642 DNA topoisomerase III; Provisional; Region: PRK07726 266264007643 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 266264007644 active site 266264007645 putative interdomain interaction site [polypeptide binding]; other site 266264007646 putative metal-binding site [ion binding]; other site 266264007647 putative nucleotide binding site [chemical binding]; other site 266264007648 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266264007649 domain I; other site 266264007650 DNA binding groove [nucleotide binding] 266264007651 phosphate binding site [ion binding]; other site 266264007652 domain II; other site 266264007653 domain III; other site 266264007654 nucleotide binding site [chemical binding]; other site 266264007655 catalytic site [active] 266264007656 domain IV; other site 266264007657 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 266264007658 Cation efflux family; Region: Cation_efflux; cl00316 266264007659 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266264007660 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266264007661 DNA binding residues [nucleotide binding] 266264007662 dimer interface [polypeptide binding]; other site 266264007663 putative metal binding site [ion binding]; other site 266264007664 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264007665 metal-binding site [ion binding] 266264007666 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 266264007667 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264007668 metal-binding site [ion binding] 266264007669 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264007670 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264007671 metal-binding site [ion binding] 266264007672 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264007673 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264007674 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 266264007675 putative transcriptional regulator MerR; Provisional; Region: PRK13752 266264007676 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 266264007677 DNA binding residues [nucleotide binding] 266264007678 dimer interface [polypeptide binding]; other site 266264007679 mercury binding site [ion binding]; other site 266264007680 MerT mercuric transport protein; Region: MerT; cl03578 266264007681 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264007682 metal-binding site [ion binding] 266264007683 mercuric reductase 266264007684 putative mercuric reductase; Provisional; Region: PRK13748 266264007685 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264007686 transposase (fragment) 266264007687 transposase (fragment) 266264007688 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 266264007689 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 266264007690 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 266264007691 Domain of unknown function (DUF932); Region: DUF932; cl12129 266264007692 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 266264007693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264007694 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266264007695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264007696 nucleotide binding region [chemical binding]; other site 266264007697 ATP-binding site [chemical binding]; other site 266264007698 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 266264007699 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 266264007700 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266264007701 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 266264007702 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 266264007703 Domain of unknown function DUF87; Region: DUF87; pfam01935 266264007704 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 266264007705 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 266264007706 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264007707 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 266264007708 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264007709 ABC transporter signature motif; other site 266264007710 Walker B; other site 266264007711 D-loop; other site 266264007712 H-loop/switch region; other site 266264007713 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 266264007714 active site 266264007715 NTP binding site [chemical binding]; other site 266264007716 metal binding triad [ion binding]; metal-binding site 266264007717 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 266264007718 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264007719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007720 Walker A motif; other site 266264007721 ATP binding site [chemical binding]; other site 266264007722 Walker B motif; other site 266264007723 arginine finger; other site 266264007724 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 266264007725 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264007726 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 266264007727 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 266264007728 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 266264007729 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 266264007730 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 266264007731 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 266264007732 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 266264007733 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 266264007734 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 266264007735 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 266264007736 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266264007737 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 266264007738 MPN+ (JAMM) motif; other site 266264007739 Zinc-binding site [ion binding]; other site 266264007740 Protein of unknown function (DUF1525); Region: DUF1525; cl06515 266264007741 TraU protein; Region: TraU; cl06067 266264007742 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 266264007743 Protein of unknown function (DUF3742); Region: DUF3742; pfam12553 266264007744 RES domain; Region: RES; cl02411 266264007745 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 266264007746 Putative helicase; Region: TraI_2; pfam07514 266264007747 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 266264007748 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264007749 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264007750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264007751 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264007752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264007753 substrate binding site [chemical binding]; other site 266264007754 oxyanion hole (OAH) forming residues; other site 266264007755 trimer interface [polypeptide binding]; other site 266264007756 DsrE/DsrF-like family; Region: DrsE; cl00672 266264007757 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264007758 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264007759 dimerization interface [polypeptide binding]; other site 266264007760 putative DNA binding site [nucleotide binding]; other site 266264007761 putative Zn2+ binding site [ion binding]; other site 266264007762 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 266264007763 active site residue [active] 266264007764 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266264007765 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264007766 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 266264007767 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266264007768 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 266264007769 Low-spin heme binding site [chemical binding]; other site 266264007770 D-pathway; other site 266264007771 Putative water exit pathway; other site 266264007772 Binuclear center (active site) [active] 266264007773 K-pathway; other site 266264007774 Putative proton exit pathway; other site 266264007775 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 266264007776 Cytochrome c; Region: Cytochrom_C; cl11414 266264007777 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264007778 Cytochrome c; Region: Cytochrom_C; cl11414 266264007779 Cytochrome c [Energy production and conversion]; Region: COG3258 266264007780 Cytochrome c; Region: Cytochrom_C; cl11414 266264007781 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264007782 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264007783 metal-binding site [ion binding] 266264007784 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264007785 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264007786 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 266264007787 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 266264007788 putative active site [active] 266264007789 catalytic triad [active] 266264007790 putative dimer interface [polypeptide binding]; other site 266264007791 Putative sensor-kinase ArmS (part 2) 266264007792 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264007793 Helix-turn-helix domains; Region: HTH; cl00088 266264007794 Integrase core domain; Region: rve; cl01316 266264007795 Putative sensor-kinase ArmS (part1) 266264007796 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 266264007797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264007798 active site 266264007799 phosphorylation site [posttranslational modification] 266264007800 intermolecular recognition site; other site 266264007801 dimerization interface [polypeptide binding]; other site 266264007802 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264007803 DNA binding site [nucleotide binding] 266264007804 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 266264007805 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264007806 Walker A/P-loop; other site 266264007807 ATP binding site [chemical binding]; other site 266264007808 Q-loop/lid; other site 266264007809 ABC transporter signature motif; other site 266264007810 Walker B; other site 266264007811 D-loop; other site 266264007812 H-loop/switch region; other site 266264007813 CcmB protein; Region: CcmB; cl01016 266264007814 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266264007815 Heme exporter protein D (CcmD); Region: CcmD; cl11475 266264007816 CcmE; Region: CcmE; cl00994 266264007817 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266264007818 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 266264007819 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 266264007820 catalytic residues [active] 266264007821 central insert; other site 266264007822 Cytochrome C biogenesis protein; Region: CcmH; cl01179 266264007823 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 266264007824 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 266264007825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264007826 binding surface 266264007827 TPR motif; other site 266264007828 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 266264007829 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 266264007830 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 266264007831 DsbD alpha interface [polypeptide binding]; other site 266264007832 catalytic residues [active] 266264007833 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 266264007834 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266264007835 catalytic residues [active] 266264007836 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 266264007837 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 266264007838 dimerization domain [polypeptide binding]; other site 266264007839 dimer interface [polypeptide binding]; other site 266264007840 catalytic residues [active] 266264007841 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 266264007842 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 266264007843 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264007844 DsrE/DsrF-like family; Region: DrsE; cl00672 266264007845 Helix-turn-helix domains; Region: HTH; cl00088 266264007846 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264007847 dimerization interface [polypeptide binding]; other site 266264007848 substrate binding pocket [chemical binding]; other site 266264007849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264007850 sequence-specific DNA binding site [nucleotide binding]; other site 266264007851 salt bridge; other site 266264007852 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264007853 dimerization interface [polypeptide binding]; other site 266264007854 tyrosine-based site specific recombinase (part 2) 266264007855 Integrase core domain; Region: rve; cl01316 266264007856 AAA domain; Region: AAA_22; pfam13401 266264007857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007858 Walker A motif; other site 266264007859 ATP binding site [chemical binding]; other site 266264007860 Walker B motif; other site 266264007861 arginine finger; other site 266264007862 tyrosine-based site specific recombinase (part1) 266264007863 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266264007864 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 266264007865 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266264007866 GIY-YIG motif/motif A; other site 266264007867 active site 266264007868 catalytic site [active] 266264007869 putative DNA binding site [nucleotide binding]; other site 266264007870 metal binding site [ion binding]; metal-binding site 266264007871 UvrB/uvrC motif; Region: UVR; pfam02151 266264007872 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 266264007873 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 266264007874 elongation factor P; Validated; Region: PRK00529 266264007875 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 266264007876 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 266264007877 RNA binding site [nucleotide binding]; other site 266264007878 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 266264007879 RNA binding site [nucleotide binding]; other site 266264007880 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 266264007881 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 266264007882 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 266264007883 active site 266264007884 hydrophilic channel; other site 266264007885 dimerization interface [polypeptide binding]; other site 266264007886 catalytic residues [active] 266264007887 active site lid [active] 266264007888 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 266264007889 Recombination protein O N terminal; Region: RecO_N; cl15812 266264007890 Recombination protein O C terminal; Region: RecO_C; pfam02565 266264007891 GTPase Era; Reviewed; Region: era; PRK00089 266264007892 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 266264007893 G1 box; other site 266264007894 GTP/Mg2+ binding site [chemical binding]; other site 266264007895 Switch I region; other site 266264007896 G2 box; other site 266264007897 Switch II region; other site 266264007898 G3 box; other site 266264007899 G4 box; other site 266264007900 G5 box; other site 266264007901 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 266264007902 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 266264007903 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 266264007904 dimerization interface [polypeptide binding]; other site 266264007905 active site 266264007906 metal binding site [ion binding]; metal-binding site 266264007907 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 266264007908 signal peptidase I; Provisional; Region: PRK10861 266264007909 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266264007910 Catalytic site [active] 266264007911 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266264007912 GTP-binding protein LepA; Provisional; Region: PRK05433 266264007913 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 266264007914 G1 box; other site 266264007915 putative GEF interaction site [polypeptide binding]; other site 266264007916 GTP/Mg2+ binding site [chemical binding]; other site 266264007917 Switch I region; other site 266264007918 G2 box; other site 266264007919 G3 box; other site 266264007920 Switch II region; other site 266264007921 G4 box; other site 266264007922 G5 box; other site 266264007923 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 266264007924 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 266264007925 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 266264007926 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266264007927 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266264007928 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266264007929 protein binding site [polypeptide binding]; other site 266264007930 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266264007931 protein binding site [polypeptide binding]; other site 266264007932 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 266264007933 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 266264007934 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 266264007935 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 266264007936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264007937 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264007938 DNA binding residues [nucleotide binding] 266264007939 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 266264007940 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266264007941 dimer interface [polypeptide binding]; other site 266264007942 active site 266264007943 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266264007944 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264007945 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266264007946 NAD(P) binding site [chemical binding]; other site 266264007947 homotetramer interface [polypeptide binding]; other site 266264007948 homodimer interface [polypeptide binding]; other site 266264007949 active site 266264007950 Acyl transferase domain; Region: Acyl_transf_1; cl08282 266264007951 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 266264007952 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 266264007953 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266264007954 dimer interface [polypeptide binding]; other site 266264007955 active site 266264007956 CoA binding pocket [chemical binding]; other site 266264007957 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 266264007958 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 266264007959 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 266264007960 Maf-like protein; Region: Maf; pfam02545 266264007961 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266264007962 active site 266264007963 dimer interface [polypeptide binding]; other site 266264007964 Predicted methyltransferases [General function prediction only]; Region: COG0313 266264007965 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266264007966 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 266264007967 tandem repeat interface [polypeptide binding]; other site 266264007968 oligomer interface [polypeptide binding]; other site 266264007969 active site residues [active] 266264007970 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266264007971 iron-sulfur cluster [ion binding]; other site 266264007972 [2Fe-2S] cluster binding site [ion binding]; other site 266264007973 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266264007974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264007975 motif II; other site 266264007976 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 266264007977 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 266264007978 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266264007979 active site 266264007980 ribonuclease E; Reviewed; Region: rne; PRK10811 266264007981 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 266264007982 homodimer interface [polypeptide binding]; other site 266264007983 oligonucleotide binding site [chemical binding]; other site 266264007984 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 266264007985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264007986 FeS/SAM binding site; other site 266264007987 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 266264007988 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266264007989 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 266264007990 GTP binding site; other site 266264007991 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266264007992 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 266264007993 dimer interface [polypeptide binding]; other site 266264007994 putative functional site; other site 266264007995 putative MPT binding site; other site 266264007996 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 266264007997 RmuC family; Region: RmuC; pfam02646 266264007998 glyoxylate reductase; Reviewed; Region: PRK13243 266264007999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008000 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266264008001 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266264008002 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 266264008003 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 266264008004 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 266264008005 active site 266264008006 Ferredoxin [Energy production and conversion]; Region: COG1146 266264008007 4Fe-4S binding domain; Region: Fer4; cl02805 266264008008 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 266264008009 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266264008010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264008011 Cupin domain; Region: Cupin_2; cl09118 266264008012 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264008013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264008014 LysE type translocator; Region: LysE; cl00565 266264008015 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 266264008016 LysE type translocator; Region: LysE; cl00565 266264008017 nodulation ABC transporter NodI; Provisional; Region: PRK13537 266264008018 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 266264008019 Walker A/P-loop; other site 266264008020 ATP binding site [chemical binding]; other site 266264008021 Q-loop/lid; other site 266264008022 ABC transporter signature motif; other site 266264008023 Walker B; other site 266264008024 D-loop; other site 266264008025 H-loop/switch region; other site 266264008026 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266264008027 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 266264008028 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266264008029 homodimer interface [polypeptide binding]; other site 266264008030 substrate-cofactor binding pocket; other site 266264008031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008032 catalytic residue [active] 266264008033 amidophosphoribosyltransferase; Provisional; Region: PRK09246 266264008034 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 266264008035 active site 266264008036 tetramer interface [polypeptide binding]; other site 266264008037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264008038 active site 266264008039 Colicin V production protein; Region: Colicin_V; cl00567 266264008040 Sporulation related domain; Region: SPOR; cl10051 266264008041 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 266264008042 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264008043 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264008044 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 266264008045 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266264008046 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 266264008047 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 266264008048 substrate binding site [chemical binding]; other site 266264008049 active site 266264008050 catalytic residues [active] 266264008051 heterodimer interface [polypeptide binding]; other site 266264008052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264008053 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 266264008054 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 266264008055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008056 catalytic residue [active] 266264008057 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 266264008058 active site 266264008059 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 266264008060 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 266264008061 dimerization interface 3.5A [polypeptide binding]; other site 266264008062 active site 266264008063 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 266264008064 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 266264008065 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 266264008066 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 266264008067 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 266264008068 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 266264008069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008070 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 266264008071 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 266264008072 tartrate dehydrogenase; Provisional; Region: PRK08194 266264008073 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266264008074 substrate binding site [chemical binding]; other site 266264008075 Entericidin EcnA/B family; Region: Entericidin; cl02322 266264008076 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266264008077 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266264008078 substrate binding site [chemical binding]; other site 266264008079 ligand binding site [chemical binding]; other site 266264008080 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 266264008081 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264008082 Walker A/P-loop; other site 266264008083 ATP binding site [chemical binding]; other site 266264008084 Q-loop/lid; other site 266264008085 ABC transporter signature motif; other site 266264008086 Walker B; other site 266264008087 D-loop; other site 266264008088 H-loop/switch region; other site 266264008089 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 266264008090 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264008091 Walker A/P-loop; other site 266264008092 ATP binding site [chemical binding]; other site 266264008093 Q-loop/lid; other site 266264008094 ABC transporter signature motif; other site 266264008095 Walker B; other site 266264008096 D-loop; other site 266264008097 H-loop/switch region; other site 266264008098 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 266264008099 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 266264008100 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264008101 TM-ABC transporter signature motif; other site 266264008102 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264008103 TM-ABC transporter signature motif; other site 266264008104 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 266264008105 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266264008106 dimerization interface [polypeptide binding]; other site 266264008107 ligand binding site [chemical binding]; other site 266264008108 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 266264008109 dimer interface [polypeptide binding]; other site 266264008110 Citrate synthase; Region: Citrate_synt; pfam00285 266264008111 active site 266264008112 citrylCoA binding site [chemical binding]; other site 266264008113 NADH binding [chemical binding]; other site 266264008114 cationic pore residues; other site 266264008115 oxalacetate/citrate binding site [chemical binding]; other site 266264008116 coenzyme A binding site [chemical binding]; other site 266264008117 catalytic triad [active] 266264008118 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 266264008119 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266264008120 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 266264008121 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 266264008122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008123 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266264008124 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 266264008125 SdhC subunit interface [polypeptide binding]; other site 266264008126 proximal heme binding site [chemical binding]; other site 266264008127 cardiolipin binding site; other site 266264008128 Iron-sulfur protein interface; other site 266264008129 proximal quinone binding site [chemical binding]; other site 266264008130 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 266264008131 Iron-sulfur protein interface; other site 266264008132 proximal quinone binding site [chemical binding]; other site 266264008133 SdhD (CybS) interface [polypeptide binding]; other site 266264008134 proximal heme binding site [chemical binding]; other site 266264008135 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266264008136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264008137 DNA-binding site [nucleotide binding]; DNA binding site 266264008138 UTRA domain; Region: UTRA; cl01230 266264008139 malate dehydrogenase; Provisional; Region: PRK05442 266264008140 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 266264008141 NAD(P) binding site [chemical binding]; other site 266264008142 dimer interface [polypeptide binding]; other site 266264008143 malate binding site [chemical binding]; other site 266264008144 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266264008145 aconitate hydratase; Provisional; Region: acnA; PRK12881 266264008146 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266264008147 substrate binding site [chemical binding]; other site 266264008148 ligand binding site [chemical binding]; other site 266264008149 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 266264008150 substrate binding site [chemical binding]; other site 266264008151 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 266264008152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264008153 S-adenosylmethionine binding site [chemical binding]; other site 266264008154 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 266264008155 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266264008156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264008157 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 266264008158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264008159 dimerization interface [polypeptide binding]; other site 266264008160 putative DNA binding site [nucleotide binding]; other site 266264008161 putative Zn2+ binding site [ion binding]; other site 266264008162 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266264008163 putative hydrophobic ligand binding site [chemical binding]; other site 266264008164 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266264008165 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264008166 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266264008167 N-terminal domain interface [polypeptide binding]; other site 266264008168 dimer interface [polypeptide binding]; other site 266264008169 substrate binding pocket (H-site) [chemical binding]; other site 266264008170 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264008171 Cytochrome c; Region: Cytochrom_C; cl11414 266264008172 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266264008173 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264008174 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 266264008175 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 266264008176 putative active site [active] 266264008177 heat shock protein 90; Provisional; Region: PRK05218 266264008178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264008179 ATP binding site [chemical binding]; other site 266264008180 Mg2+ binding site [ion binding]; other site 266264008181 G-X-G motif; other site 266264008182 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264008183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264008184 DNA-binding site [nucleotide binding]; DNA binding site 266264008185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264008186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008187 homodimer interface [polypeptide binding]; other site 266264008188 catalytic residue [active] 266264008189 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266264008190 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 266264008191 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 266264008192 LysE type translocator; Region: LysE; cl00565 266264008193 EamA-like transporter family; Region: EamA; cl01037 266264008194 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266264008195 homotrimer interaction site [polypeptide binding]; other site 266264008196 putative active site [active] 266264008197 aspartate aminotransferase; Provisional; Region: PRK05764 266264008198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264008199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008200 homodimer interface [polypeptide binding]; other site 266264008201 catalytic residue [active] 266264008202 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264008203 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 266264008204 putative C-terminal domain interface [polypeptide binding]; other site 266264008205 putative GSH binding site (G-site) [chemical binding]; other site 266264008206 putative dimer interface [polypeptide binding]; other site 266264008207 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 266264008208 putative N-terminal domain interface [polypeptide binding]; other site 266264008209 putative dimer interface [polypeptide binding]; other site 266264008210 putative substrate binding pocket (H-site) [chemical binding]; other site 266264008211 glycolate transporter; Provisional; Region: PRK09695 266264008212 L-lactate permease; Region: Lactate_perm; cl00701 266264008213 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266264008214 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266264008215 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 266264008216 Walker A/P-loop; other site 266264008217 ATP binding site [chemical binding]; other site 266264008218 Q-loop/lid; other site 266264008219 ABC transporter signature motif; other site 266264008220 Walker B; other site 266264008221 D-loop; other site 266264008222 H-loop/switch region; other site 266264008223 Chromate transporter; Region: Chromate_transp; pfam02417 266264008224 Chromate transporter; Region: Chromate_transp; pfam02417 266264008225 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 266264008226 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 266264008227 CAP-like domain; other site 266264008228 active site 266264008229 primary dimer interface [polypeptide binding]; other site 266264008230 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266264008231 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264008232 catalytic residue [active] 266264008233 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 266264008234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264008235 ATP binding site [chemical binding]; other site 266264008236 Mg2+ binding site [ion binding]; other site 266264008237 G-X-G motif; other site 266264008238 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266264008239 anchoring element; other site 266264008240 dimer interface [polypeptide binding]; other site 266264008241 ATP binding site [chemical binding]; other site 266264008242 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266264008243 active site 266264008244 metal binding site [ion binding]; metal-binding site 266264008245 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266264008246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264008247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264008248 putative substrate translocation pore; other site 266264008249 ABC transporter ATPase component; Reviewed; Region: PRK11147 266264008250 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264008251 Walker A/P-loop; other site 266264008252 ATP binding site [chemical binding]; other site 266264008253 Q-loop/lid; other site 266264008254 ABC transporter signature motif; other site 266264008255 Walker B; other site 266264008256 D-loop; other site 266264008257 H-loop/switch region; other site 266264008258 ABC transporter; Region: ABC_tran_2; pfam12848 266264008259 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264008260 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264008261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264008262 DNA binding residues [nucleotide binding] 266264008263 dimerization interface [polypeptide binding]; other site 266264008264 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264008265 AMP-binding enzyme; Region: AMP-binding; cl15778 266264008266 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264008267 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264008268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008269 NAD(P) binding site [chemical binding]; other site 266264008270 active site 266264008271 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 266264008272 active site 266264008273 catalytic site [active] 266264008274 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266264008275 active site 266264008276 catalytic site [active] 266264008277 lipid-transfer protein; Provisional; Region: PRK08256 266264008278 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264008279 active site 266264008280 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264008281 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264008282 active site 266264008283 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264008284 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264008285 active site 266264008286 lipid-transfer protein; Provisional; Region: PRK08256 266264008287 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264008288 active site 266264008289 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264008290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008291 NAD(P) binding site [chemical binding]; other site 266264008292 active site 266264008293 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264008294 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264008295 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264008296 DNA binding residues [nucleotide binding] 266264008297 dimerization interface [polypeptide binding]; other site 266264008298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264008299 NMT1-like family; Region: NMT1_2; cl15260 266264008300 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264008301 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264008302 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264008303 trimer interface [polypeptide binding]; other site 266264008304 eyelet of channel; other site 266264008305 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266264008306 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264008307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264008308 substrate binding pocket [chemical binding]; other site 266264008309 membrane-bound complex binding site; other site 266264008310 hinge residues; other site 266264008311 benzoate transporter; Region: benE; TIGR00843 266264008312 Benzoate membrane transport protein; Region: BenE; pfam03594 266264008313 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 266264008314 Fimbrial protein; Region: Fimbrial; cl01416 266264008315 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264008316 AAA domain; Region: AAA_22; pfam13401 266264008317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264008318 Walker A motif; other site 266264008319 ATP binding site [chemical binding]; other site 266264008320 Walker B motif; other site 266264008321 arginine finger; other site 266264008322 Integrase core domain; Region: rve; cl01316 266264008323 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 266264008324 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 266264008325 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 266264008326 HTH-like domain; Region: HTH_21; pfam13276 266264008327 Integrase core domain; Region: rve; cl01316 266264008328 Integrase core domain; Region: rve_3; cl15866 266264008329 Helix-turn-helix domains; Region: HTH; cl00088 266264008330 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266264008331 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 266264008332 catalytic residues [active] 266264008333 catalytic nucleophile [active] 266264008334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264008335 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266264008336 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264008337 active site 266264008338 Int/Topo IB signature motif; other site 266264008339 DNA binding site [nucleotide binding] 266264008340 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 266264008341 active site 266264008342 helicase 45; Provisional; Region: PTZ00424 266264008343 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266264008344 ATP binding site [chemical binding]; other site 266264008345 Mg++ binding site [ion binding]; other site 266264008346 motif III; other site 266264008347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264008348 nucleotide binding region [chemical binding]; other site 266264008349 ATP-binding site [chemical binding]; other site 266264008350 TIGR03440 family protein; Region: unchr_TIGR03440 266264008351 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 266264008352 probable methyltransferase; Region: TIGR03438 266264008353 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 266264008355 Integral membrane protein TerC family; Region: TerC; cl10468 266264008356 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 266264008357 dimerization interface [polypeptide binding]; other site 266264008358 active site 266264008359 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 266264008360 folate binding site [chemical binding]; other site 266264008361 NADP+ binding site [chemical binding]; other site 266264008362 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 266264008363 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 266264008364 Protein of unknown function (DUF615); Region: DUF615; cl01147 266264008365 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 266264008366 MPT binding site; other site 266264008367 trimer interface [polypeptide binding]; other site 266264008368 Membrane transport protein; Region: Mem_trans; cl09117 266264008369 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 266264008370 catalytic site [active] 266264008371 putative active site [active] 266264008372 putative substrate binding site [chemical binding]; other site 266264008373 dimer interface [polypeptide binding]; other site 266264008374 Peptidase family M48; Region: Peptidase_M48; cl12018 266264008375 GTPase RsgA; Reviewed; Region: PRK00098 266264008376 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 266264008377 RNA binding site [nucleotide binding]; other site 266264008378 homodimer interface [polypeptide binding]; other site 266264008379 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 266264008380 GTPase/Zn-binding domain interface [polypeptide binding]; other site 266264008381 GTP/Mg2+ binding site [chemical binding]; other site 266264008382 G4 box; other site 266264008383 G5 box; other site 266264008384 G1 box; other site 266264008385 Switch I region; other site 266264008386 G2 box; other site 266264008387 G3 box; other site 266264008388 Switch II region; other site 266264008389 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 266264008390 CobD/Cbib protein; Region: CobD_Cbib; cl00561 266264008391 Cupin domain; Region: Cupin_2; cl09118 266264008392 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 266264008393 Helix-turn-helix domains; Region: HTH; cl00088 266264008394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264008395 dimerization interface [polypeptide binding]; other site 266264008396 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264008397 active site 266264008398 HIGH motif; other site 266264008399 nucleotide binding site [chemical binding]; other site 266264008400 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264008401 active site 266264008402 KMSKS motif; other site 266264008403 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266264008404 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266264008405 ATP binding site [chemical binding]; other site 266264008406 Mg++ binding site [ion binding]; other site 266264008407 motif III; other site 266264008408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264008409 nucleotide binding region [chemical binding]; other site 266264008410 ATP-binding site [chemical binding]; other site 266264008411 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 266264008412 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 266264008413 Interdomain contacts; other site 266264008414 Cytokine receptor motif; other site 266264008415 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266264008416 putative active site [active] 266264008417 putative metal binding site [ion binding]; other site 266264008418 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266264008419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264008420 NMT1-like family; Region: NMT1_2; cl15260 266264008421 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 266264008422 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264008423 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264008424 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266264008425 Helix-turn-helix domains; Region: HTH; cl00088 266264008426 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264008427 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264008428 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266264008429 C-terminal domain interface [polypeptide binding]; other site 266264008430 GSH binding site (G-site) [chemical binding]; other site 266264008431 dimer interface [polypeptide binding]; other site 266264008432 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 266264008433 dimer interface [polypeptide binding]; other site 266264008434 N-terminal domain interface [polypeptide binding]; other site 266264008435 putative substrate binding pocket (H-site) [chemical binding]; other site 266264008436 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 266264008437 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 266264008438 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 266264008439 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266264008440 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266264008441 Helix-turn-helix domains; Region: HTH; cl00088 266264008442 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264008443 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 266264008444 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 266264008445 homodimer interface [polypeptide binding]; other site 266264008446 active site 266264008447 TDP-binding site; other site 266264008448 acceptor substrate-binding pocket; other site 266264008449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264008450 NMT1-like family; Region: NMT1_2; cl15260 266264008451 putative CoA-transferase; Provisional; Region: PRK11430 266264008452 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264008453 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266264008454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008455 CoA-ligase; Region: Ligase_CoA; cl02894 266264008456 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264008457 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264008458 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264008459 active site 266264008460 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264008461 Helix-turn-helix domains; Region: HTH; cl00088 266264008462 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264008463 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264008464 lipid-transfer protein; Provisional; Region: PRK08256 266264008465 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264008466 active site 266264008467 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 266264008468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264008469 substrate binding site [chemical binding]; other site 266264008470 oxyanion hole (OAH) forming residues; other site 266264008471 trimer interface [polypeptide binding]; other site 266264008472 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264008473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008474 NAD(P) binding site [chemical binding]; other site 266264008475 active site 266264008476 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264008477 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264008478 FMN binding site [chemical binding]; other site 266264008479 substrate binding site [chemical binding]; other site 266264008480 putative catalytic residue [active] 266264008481 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266264008482 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266264008483 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266264008484 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266264008485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264008486 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266264008487 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264008488 DNA binding residues [nucleotide binding] 266264008489 DNA primase; Validated; Region: dnaG; PRK05667 266264008490 CHC2 zinc finger; Region: zf-CHC2; cl15369 266264008491 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 266264008492 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 266264008493 active site 266264008494 metal binding site [ion binding]; metal-binding site 266264008495 interdomain interaction site; other site 266264008496 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 266264008497 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 266264008498 GatB domain; Region: GatB_Yqey; cl11497 266264008499 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 266264008500 HI0933-like protein; Region: HI0933_like; pfam03486 266264008501 UGMP family protein; Validated; Region: PRK09604 266264008502 PhoD-like phosphatase; Region: PhoD; pfam09423 266264008503 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266264008504 putative active site [active] 266264008505 putative metal binding site [ion binding]; other site 266264008506 PhoD-like phosphatase; Region: PhoD; pfam09423 266264008507 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266264008508 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 266264008509 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 266264008510 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 266264008511 TPP-binding site; other site 266264008512 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266264008513 PYR/PP interface [polypeptide binding]; other site 266264008514 dimer interface [polypeptide binding]; other site 266264008515 TPP binding site [chemical binding]; other site 266264008516 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266264008517 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266264008518 substrate binding pocket [chemical binding]; other site 266264008519 chain length determination region; other site 266264008520 substrate-Mg2+ binding site; other site 266264008521 catalytic residues [active] 266264008522 aspartate-rich region 1; other site 266264008523 active site lid residues [active] 266264008524 aspartate-rich region 2; other site 266264008525 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 266264008526 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266264008527 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266264008528 [2Fe-2S] cluster binding site [ion binding]; other site 266264008529 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 266264008530 alpha subunit interface [polypeptide binding]; other site 266264008531 active site 266264008532 substrate binding site [chemical binding]; other site 266264008533 Fe binding site [ion binding]; other site 266264008534 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266264008535 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266264008536 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266264008537 active site residue [active] 266264008538 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266264008539 active site residue [active] 266264008540 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 266264008541 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266264008542 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264008543 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266264008544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264008545 K+-transporting ATPase, c chain; Region: KdpC; cl00944 266264008546 DNA polymerase I; Provisional; Region: PRK05755 266264008547 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 266264008548 active site 266264008549 metal binding site 1 [ion binding]; metal-binding site 266264008550 putative 5' ssDNA interaction site; other site 266264008551 metal binding site 3; metal-binding site 266264008552 metal binding site 2 [ion binding]; metal-binding site 266264008553 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 266264008554 putative DNA binding site [nucleotide binding]; other site 266264008555 putative metal binding site [ion binding]; other site 266264008556 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 266264008557 active site 266264008558 catalytic site [active] 266264008559 substrate binding site [chemical binding]; other site 266264008560 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 266264008561 active site 266264008562 DNA binding site [nucleotide binding] 266264008563 catalytic site [active] 266264008564 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266264008565 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 266264008566 Phosphotransferase enzyme family; Region: APH; pfam01636 266264008567 putative active site [active] 266264008568 putative substrate binding site [chemical binding]; other site 266264008569 ATP binding site [chemical binding]; other site 266264008570 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 266264008571 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264008572 Family description; Region: UvrD_C_2; cl15862 266264008573 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 266264008574 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266264008575 HIGH motif; other site 266264008576 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266264008577 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266264008578 active site 266264008579 KMSKS motif; other site 266264008580 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 266264008581 tRNA binding surface [nucleotide binding]; other site 266264008582 anticodon binding site; other site 266264008583 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 266264008584 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266264008585 active site 266264008586 tetramer interface; other site 266264008587 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266264008588 putative active site pocket [active] 266264008589 dimerization interface [polypeptide binding]; other site 266264008590 putative catalytic residue [active] 266264008591 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266264008592 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 266264008593 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266264008594 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266264008595 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 266264008596 AMP-binding enzyme; Region: AMP-binding; cl15778 266264008597 AMP-binding enzyme; Region: AMP-binding; cl15778 266264008598 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 266264008599 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 266264008600 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 266264008601 AAA domain; Region: AAA_33; pfam13671 266264008602 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264008603 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 266264008604 putative ATP binding site [chemical binding]; other site 266264008605 putative substrate interface [chemical binding]; other site 266264008606 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 266264008607 AsmA-like C-terminal region; Region: AsmA_2; cl15864 266264008608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264008609 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264008610 putative substrate translocation pore; other site 266264008611 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 266264008612 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266264008613 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 266264008614 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 266264008615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264008616 S-adenosylmethionine binding site [chemical binding]; other site 266264008617 Protein of unknown function DUF72; Region: DUF72; cl00777 266264008618 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 266264008619 Flavin Reductases; Region: FlaRed; cl00801 266264008620 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264008621 Helix-turn-helix domains; Region: HTH; cl00088 266264008622 AsnC family; Region: AsnC_trans_reg; pfam01037 266264008623 Putative cyclase 266264008624 Putative cyclase; Region: Cyclase; cl00814 266264008625 kynureninase; Region: kynureninase; TIGR01814 266264008626 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264008627 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264008628 catalytic residue [active] 266264008629 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 266264008630 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264008631 Helix-turn-helix domains; Region: HTH; cl00088 266264008632 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 266264008633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264008634 FAD binding site [chemical binding]; other site 266264008635 substrate binding pocket [chemical binding]; other site 266264008636 catalytic base [active] 266264008637 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266264008638 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266264008639 dimer interface [polypeptide binding]; other site 266264008640 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266264008641 catalytic triad [active] 266264008642 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 266264008643 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 266264008644 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 266264008645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264008646 metal binding site [ion binding]; metal-binding site 266264008647 active site 266264008648 I-site; other site 266264008649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264008650 PAS fold; Region: PAS_3; pfam08447 266264008651 putative active site [active] 266264008652 heme pocket [chemical binding]; other site 266264008653 hypothetical protein; Provisional; Region: PRK13560 266264008654 D5 N terminal like; Region: D5_N; cl07360 266264008655 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 266264008656 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 266264008657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264008658 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264008659 Walker A motif; other site 266264008660 ATP binding site [chemical binding]; other site 266264008661 Walker B motif; other site 266264008662 arginine finger; other site 266264008663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264008664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264008665 Predicted transporter component [General function prediction only]; Region: COG2391 266264008666 Sulphur transport; Region: Sulf_transp; cl01018 266264008667 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266264008668 Ligand Binding Site [chemical binding]; other site 266264008669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 266264008670 Bul1 N terminus; Region: Bul1_N; pfam04425 266264008671 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264008672 ligand binding site [chemical binding]; other site 266264008673 translocation protein TolB; Provisional; Region: tolB; PRK02889 266264008674 TolB amino-terminal domain; Region: TolB_N; cl00639 266264008675 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266264008676 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266264008677 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266264008678 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266264008679 Gram-negative bacterial tonB protein; Region: TonB; cl10048 266264008680 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 266264008681 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266264008682 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264008683 active site 266264008684 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266264008685 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266264008686 dimer interface [polypeptide binding]; other site 266264008687 active site 266264008688 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266264008689 folate binding site [chemical binding]; other site 266264008690 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 266264008691 ATP cone domain; Region: ATP-cone; pfam03477 266264008692 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 266264008693 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 266264008694 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 266264008695 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 266264008696 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 266264008697 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 266264008698 catalytic motif [active] 266264008699 Zn binding site [ion binding]; other site 266264008700 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266264008701 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 266264008702 Lumazine binding domain; Region: Lum_binding; pfam00677 266264008703 Lumazine binding domain; Region: Lum_binding; pfam00677 266264008704 Putative motility protein; Region: YjfB_motility; pfam14070 266264008705 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266264008706 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264008707 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 266264008708 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 266264008709 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 266264008710 dimerization interface [polypeptide binding]; other site 266264008711 active site 266264008712 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 266264008713 homopentamer interface [polypeptide binding]; other site 266264008714 active site 266264008715 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 266264008716 putative RNA binding site [nucleotide binding]; other site 266264008717 aminotransferase; Validated; Region: PRK07337 266264008718 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264008719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008720 homodimer interface [polypeptide binding]; other site 266264008721 catalytic residue [active] 266264008722 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266264008723 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264008724 catalytic residue [active] 266264008725 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 266264008726 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 266264008727 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 266264008728 AMP-binding enzyme; Region: AMP-binding; cl15778 266264008729 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 266264008730 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264008731 putative C-terminal domain interface [polypeptide binding]; other site 266264008732 putative GSH binding site (G-site) [chemical binding]; other site 266264008733 putative dimer interface [polypeptide binding]; other site 266264008734 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 266264008735 putative N-terminal domain interface [polypeptide binding]; other site 266264008736 putative dimer interface [polypeptide binding]; other site 266264008737 putative substrate binding pocket (H-site) [chemical binding]; other site 266264008738 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 266264008739 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 266264008740 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 266264008741 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 266264008742 active site 266264008743 catalytic residues [active] 266264008744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264008745 Bacitracin resistance protein BacA; Region: BacA; cl00858 266264008746 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 266264008747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264008748 Helix-turn-helix domains; Region: HTH; cl00088 266264008749 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266264008750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264008751 S-adenosylmethionine binding site [chemical binding]; other site 266264008752 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264008753 active site residue [active] 266264008754 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 266264008755 O-Antigen ligase; Region: Wzy_C; cl04850 266264008756 META domain; Region: META; cl01245 266264008757 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 266264008758 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 266264008759 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 266264008760 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266264008761 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 266264008762 putative active site [active] 266264008763 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 266264008764 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 266264008765 active site 266264008766 substrate binding site [chemical binding]; other site 266264008767 metal binding site [ion binding]; metal-binding site 266264008768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264008769 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 266264008770 putative ADP-binding pocket [chemical binding]; other site 266264008771 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 266264008772 Bacterial sugar transferase; Region: Bac_transf; cl00939 266264008773 This family is most closely related to the GT1 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor...; Region: GT1_WbdM_like; cd04951 266264008774 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 266264008775 MatE; Region: MatE; cl10513 266264008776 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 266264008777 putative ADP-binding pocket [chemical binding]; other site 266264008778 Chain length determinant protein; Region: Wzz; cl15801 266264008779 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 266264008780 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266264008781 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 266264008782 NAD(P) binding site [chemical binding]; other site 266264008783 homodimer interface [polypeptide binding]; other site 266264008784 substrate binding site [chemical binding]; other site 266264008785 active site 266264008786 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266264008787 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266264008788 inhibitor-cofactor binding pocket; inhibition site 266264008789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008790 catalytic residue [active] 266264008791 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 266264008792 putative trimer interface [polypeptide binding]; other site 266264008793 putative CoA binding site [chemical binding]; other site 266264008794 hypothetical protein 266264008795 Bacterial sugar transferase; Region: Bac_transf; cl00939 266264008796 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 266264008797 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 266264008798 putative ADP-binding pocket [chemical binding]; other site 266264008799 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266264008800 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266264008801 active site 266264008802 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266264008803 MatE; Region: MatE; cl10513 266264008804 Cupin domain; Region: Cupin_2; cl09118 266264008805 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 266264008806 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 266264008807 substrate binding site; other site 266264008808 tetramer interface; other site 266264008809 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 266264008810 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 266264008811 NADP binding site [chemical binding]; other site 266264008812 active site 266264008813 putative substrate binding site [chemical binding]; other site 266264008814 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 266264008815 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 266264008816 NAD binding site [chemical binding]; other site 266264008817 substrate binding site [chemical binding]; other site 266264008818 homodimer interface [polypeptide binding]; other site 266264008819 active site 266264008820 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 266264008821 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 266264008822 active site 266264008823 metal binding site [ion binding]; metal-binding site 266264008824 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266264008825 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266264008826 putative acyl-acceptor binding pocket; other site 266264008827 dihydroorotase; Provisional; Region: PRK07627 266264008828 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264008829 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 266264008830 active site 266264008831 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 266264008832 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266264008833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264008835 active site 266264008836 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 266264008837 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 266264008838 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266264008839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 266264008840 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 266264008841 active site 266264008842 uracil binding [chemical binding]; other site 266264008843 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 266264008844 DNA photolyase; Region: DNA_photolyase; pfam00875 266264008845 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 266264008846 OpgC protein; Region: OpgC_C; cl00792 266264008847 hemY protein; Region: hemY_coli; TIGR00540 266264008848 HemY protein N-terminus; Region: HemY_N; pfam07219 266264008849 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 266264008850 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 266264008851 active site 266264008852 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 266264008853 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 266264008854 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 266264008855 domain interfaces; other site 266264008856 active site 266264008857 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 266264008858 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 266264008859 argininosuccinate lyase; Provisional; Region: PRK00855 266264008860 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266264008861 active sites [active] 266264008862 tetramer interface [polypeptide binding]; other site 266264008863 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 266264008864 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 266264008865 arginine decarboxylase; Provisional; Region: PRK15029 266264008866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 266264008867 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264008868 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264008869 catalytic residue [active] 266264008870 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 266264008871 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266264008872 trimer interface [polypeptide binding]; other site 266264008873 active site 266264008874 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 266264008875 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 266264008876 E-class dimer interface [polypeptide binding]; other site 266264008877 P-class dimer interface [polypeptide binding]; other site 266264008878 active site 266264008879 Cu2+ binding site [ion binding]; other site 266264008880 Zn2+ binding site [ion binding]; other site 266264008881 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266264008882 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 266264008883 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 266264008884 4Fe-4S binding domain; Region: Fer4; cl02805 266264008885 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 266264008886 [4Fe-4S] binding site [ion binding]; other site 266264008887 molybdopterin cofactor binding site; other site 266264008888 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266264008889 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 266264008890 molybdopterin cofactor binding site; other site 266264008891 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 266264008892 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 266264008893 4Fe-4S binding domain; Region: Fer4; cl02805 266264008894 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266264008895 4Fe-4S binding domain; Region: Fer4; cl02805 266264008896 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 266264008897 hydrogenase 4 subunit H; Validated; Region: PRK08222 266264008898 4Fe-4S binding domain; Region: Fer4; cl02805 266264008899 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 266264008900 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 266264008901 antiporter inner membrane protein; Provisional; Region: PRK11670 266264008902 Domain of unknown function DUF59; Region: DUF59; cl00941 266264008903 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 266264008904 Walker A motif; other site 266264008905 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264008906 ligand binding site [chemical binding]; other site 266264008907 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 266264008908 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 266264008909 active site 266264008910 HIGH motif; other site 266264008911 KMSKS motif; other site 266264008912 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 266264008913 tRNA binding surface [nucleotide binding]; other site 266264008914 anticodon binding site; other site 266264008915 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 266264008916 dimer interface [polypeptide binding]; other site 266264008917 putative tRNA-binding site [nucleotide binding]; other site 266264008918 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 266264008919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 266264008920 Family of unknown function (DUF490); Region: DUF490; pfam04357 266264008921 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 266264008922 Surface antigen; Region: Bac_surface_Ag; cl03097 266264008923 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 266264008924 ScpA/B protein; Region: ScpA_ScpB; cl00598 266264008925 pantoate--beta-alanine ligase; Region: panC; TIGR00018 266264008926 Pantoate-beta-alanine ligase; Region: PanC; cd00560 266264008927 active site 266264008928 ATP-binding site [chemical binding]; other site 266264008929 pantoate-binding site; other site 266264008930 HXXH motif; other site 266264008931 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 266264008932 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 266264008933 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 266264008934 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266264008935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264008936 Coenzyme A binding pocket [chemical binding]; other site 266264008937 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266264008938 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264008939 P-loop; other site 266264008940 Magnesium ion binding site [ion binding]; other site 266264008941 cobyric acid synthase; Provisional; Region: PRK00784 266264008942 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264008943 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264008944 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 266264008945 catalytic triad [active] 266264008946 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 266264008947 homotrimer interface [polypeptide binding]; other site 266264008948 Walker A motif; other site 266264008949 GTP binding site [chemical binding]; other site 266264008950 Walker B motif; other site 266264008951 CobD/Cbib protein; Region: CobD_Cbib; cl00561 266264008952 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 266264008953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264008954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008955 homodimer interface [polypeptide binding]; other site 266264008956 catalytic residue [active] 266264008957 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 266264008958 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 266264008959 cobalamin binding residues [chemical binding]; other site 266264008960 putative BtuC binding residues; other site 266264008961 dimer interface [polypeptide binding]; other site 266264008962 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264008963 catalytic core [active] 266264008964 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 266264008965 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 266264008966 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 266264008967 active site pocket [active] 266264008968 putative dimer interface [polypeptide binding]; other site 266264008969 putative cataytic base [active] 266264008970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264008971 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 266264008972 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 266264008973 homodimer interface [polypeptide binding]; other site 266264008974 Walker A motif; other site 266264008975 ATP binding site [chemical binding]; other site 266264008976 hydroxycobalamin binding site [chemical binding]; other site 266264008977 Walker B motif; other site 266264008978 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266264008979 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266264008980 Walker A/P-loop; other site 266264008981 ATP binding site [chemical binding]; other site 266264008982 Q-loop/lid; other site 266264008983 ABC transporter signature motif; other site 266264008984 Walker B; other site 266264008985 D-loop; other site 266264008986 H-loop/switch region; other site 266264008987 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266264008988 ABC-ATPase subunit interface; other site 266264008989 dimer interface [polypeptide binding]; other site 266264008990 putative PBP binding regions; other site 266264008991 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 266264008992 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264008993 N-terminal plug; other site 266264008994 ligand-binding site [chemical binding]; other site 266264008996 Cell division protein ZapA; Region: ZapA; cl01146 266264008997 EVE domain; Region: EVE; cl00728 266264008998 Protein of unknown function (DUF541); Region: SIMPL; cl01077 266264008999 malonyl-CoA synthase; Validated; Region: PRK07514 266264009000 AMP-binding enzyme; Region: AMP-binding; cl15778 266264009001 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264009002 enoyl-CoA hydratase; Provisional; Region: PRK06127 266264009003 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264009004 substrate binding site [chemical binding]; other site 266264009005 oxyanion hole (OAH) forming residues; other site 266264009006 trimer interface [polypeptide binding]; other site 266264009007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264009008 NMT1-like family; Region: NMT1_2; cl15260 266264009009 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 266264009010 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264009011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264009012 DNA-binding site [nucleotide binding]; DNA binding site 266264009013 FCD domain; Region: FCD; cl11656 266264009014 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 266264009015 Peptidase family M48; Region: Peptidase_M48; cl12018 266264009016 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 266264009017 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264009018 Helix-turn-helix domains; Region: HTH; cl00088 266264009019 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 266264009020 putative dimerization interface [polypeptide binding]; other site 266264009021 putative substrate binding pocket [chemical binding]; other site 266264009022 Dehydratase family; Region: ILVD_EDD; cl00340 266264009023 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 266264009024 multifunctional aminopeptidase A; Provisional; Region: PRK00913 266264009025 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266264009026 interface (dimer of trimers) [polypeptide binding]; other site 266264009027 Substrate-binding/catalytic site; other site 266264009028 Zn-binding sites [ion binding]; other site 266264009029 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 266264009030 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266264009031 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 266264009032 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266264009033 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 266264009034 putative active site [active] 266264009035 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 266264009036 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 266264009037 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 266264009038 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 266264009039 CysD dimerization site [polypeptide binding]; other site 266264009040 G1 box; other site 266264009041 putative GEF interaction site [polypeptide binding]; other site 266264009042 GTP/Mg2+ binding site [chemical binding]; other site 266264009043 Switch I region; other site 266264009044 G2 box; other site 266264009045 G3 box; other site 266264009046 Switch II region; other site 266264009047 G4 box; other site 266264009048 G5 box; other site 266264009049 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 266264009050 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 266264009051 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 266264009052 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266264009053 Active Sites [active] 266264009054 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 266264009055 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266264009056 Active Sites [active] 266264009057 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 266264009058 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 266264009059 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266264009060 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266264009061 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264009062 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 266264009063 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 266264009064 Helix-turn-helix domains; Region: HTH; cl00088 266264009065 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 266264009066 substrate binding site [chemical binding]; other site 266264009067 dimerization interface [polypeptide binding]; other site 266264009068 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 266264009069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264009070 S-adenosylmethionine binding site [chemical binding]; other site 266264009071 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264009072 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 266264009073 putative ligand binding site [chemical binding]; other site 266264009074 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266264009075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009076 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264009077 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 266264009078 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 266264009079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264009080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264009081 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264009082 Walker A/P-loop; other site 266264009083 ATP binding site [chemical binding]; other site 266264009084 Relaxase/mobilization nuclease topoisomerase/primase fusion protein (fragment) 266264009085 AAA domain; Region: AAA_22; pfam13401 266264009086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264009087 Walker A motif; other site 266264009088 ATP binding site [chemical binding]; other site 266264009089 Walker B motif; other site 266264009090 arginine finger; other site 266264009091 Integrase core domain; Region: rve; cl01316 266264009092 relaxase/mobilization nuclease domain-containing protein (fragment)(CMGI-5) 266264009093 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264009094 Helix-turn-helix domains; Region: HTH; cl00088 266264009095 Integrase core domain; Region: rve; cl01316 266264009096 conserved hypothetical protein 266264009097 hypothetical protein 266264009098 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 266264009099 Domain of unknown function DUF29; Region: DUF29; pfam01724 266264009100 putative transcriptional regulator (fragment) 266264009101 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 266264009102 active site 266264009103 catalytic site [active] 266264009104 substrate binding site [chemical binding]; other site 266264009105 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264009106 active site 266264009107 DNA binding site [nucleotide binding] 266264009108 Int/Topo IB signature motif; other site 266264009109 Outer membrane autotransporter barrel (fragment) 266264009110 Peptidase family M48; Region: Peptidase_M48; cl12018 266264009111 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266264009112 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 266264009113 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 266264009114 active site 266264009115 imidazolonepropionase; Validated; Region: PRK09356 266264009116 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 266264009117 active site 266264009118 HutD; Region: HutD; cl01532 266264009119 urocanate hydratase; Provisional; Region: PRK05414 266264009120 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266264009121 active sites [active] 266264009122 tetramer interface [polypeptide binding]; other site 266264009123 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266264009124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264009125 DNA-binding site [nucleotide binding]; DNA binding site 266264009126 UTRA domain; Region: UTRA; cl01230 266264009127 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264009128 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266264009129 Walker A/P-loop; other site 266264009130 ATP binding site [chemical binding]; other site 266264009131 Q-loop/lid; other site 266264009132 ABC transporter signature motif; other site 266264009133 Walker B; other site 266264009134 D-loop; other site 266264009135 H-loop/switch region; other site 266264009136 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264009137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264009138 dimer interface [polypeptide binding]; other site 266264009139 conserved gate region; other site 266264009140 putative PBP binding loops; other site 266264009141 ABC-ATPase subunit interface; other site 266264009142 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266264009143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264009144 substrate binding pocket [chemical binding]; other site 266264009145 membrane-bound complex binding site; other site 266264009146 hinge residues; other site 266264009147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009148 NAD(P) binding site [chemical binding]; other site 266264009149 active site 266264009150 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266264009151 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264009152 catalytic loop [active] 266264009153 iron binding site [ion binding]; other site 266264009154 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 266264009155 FAD binding pocket [chemical binding]; other site 266264009156 FAD binding motif [chemical binding]; other site 266264009157 phosphate binding motif [ion binding]; other site 266264009158 beta-alpha-beta structure motif; other site 266264009159 NAD binding pocket [chemical binding]; other site 266264009160 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 266264009161 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264009162 inhibitor-cofactor binding pocket; inhibition site 266264009163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264009164 catalytic residue [active] 266264009165 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264009166 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264009167 Walker A/P-loop; other site 266264009168 ATP binding site [chemical binding]; other site 266264009169 Q-loop/lid; other site 266264009170 ABC transporter signature motif; other site 266264009171 Walker B; other site 266264009172 D-loop; other site 266264009173 H-loop/switch region; other site 266264009174 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264009175 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264009176 Walker A/P-loop; other site 266264009177 ATP binding site [chemical binding]; other site 266264009178 Q-loop/lid; other site 266264009179 ABC transporter signature motif; other site 266264009180 Walker B; other site 266264009181 D-loop; other site 266264009182 H-loop/switch region; other site 266264009183 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264009184 TM-ABC transporter signature motif; other site 266264009185 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264009186 TM-ABC transporter signature motif; other site 266264009187 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264009188 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266264009189 dimerization interface [polypeptide binding]; other site 266264009190 ligand binding site [chemical binding]; other site 266264009191 LytB protein; Region: LYTB; cl00507 266264009192 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 266264009193 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 266264009194 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 266264009195 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 266264009196 L-aspartate oxidase; Provisional; Region: PRK09077 266264009197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009198 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266264009199 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 266264009200 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266264009201 dimerization interface [polypeptide binding]; other site 266264009202 active site 266264009203 Quinolinate synthetase A protein; Region: NadA; cl00420 266264009204 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 266264009205 Di-iron ligands [ion binding]; other site 266264009206 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266264009207 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 266264009208 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264009209 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 266264009210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264009211 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 266264009212 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 266264009213 active site 266264009214 substrate binding site [chemical binding]; other site 266264009215 cosubstrate binding site; other site 266264009216 catalytic site [active] 266264009217 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 266264009218 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266264009219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264009220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009221 active site 266264009222 phosphorylation site [posttranslational modification] 266264009223 intermolecular recognition site; other site 266264009224 dimerization interface [polypeptide binding]; other site 266264009225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264009226 DNA binding residues [nucleotide binding] 266264009227 dimerization interface [polypeptide binding]; other site 266264009228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266264009229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264009230 ATP binding site [chemical binding]; other site 266264009231 Mg2+ binding site [ion binding]; other site 266264009232 G-X-G motif; other site 266264009233 Response regulator receiver domain; Region: Response_reg; pfam00072 266264009234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009235 active site 266264009236 phosphorylation site [posttranslational modification] 266264009237 intermolecular recognition site; other site 266264009238 dimerization interface [polypeptide binding]; other site 266264009239 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 266264009240 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 266264009241 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 266264009242 putative active site [active] 266264009243 putative NTP binding site [chemical binding]; other site 266264009244 putative nucleic acid binding site [nucleotide binding]; other site 266264009245 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 266264009246 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266264009247 active site 266264009248 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 266264009249 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 266264009250 active site 266264009251 Riboflavin kinase; Region: Flavokinase; cl03312 266264009252 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 266264009253 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264009254 active site 266264009255 HIGH motif; other site 266264009256 nucleotide binding site [chemical binding]; other site 266264009257 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266264009258 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 266264009259 active site 266264009260 KMSKS motif; other site 266264009261 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 266264009262 tRNA binding surface [nucleotide binding]; other site 266264009263 anticodon binding site; other site 266264009264 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266264009265 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 266264009266 lipoprotein signal peptidase; Provisional; Region: PRK14787 266264009267 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 266264009268 Flavoprotein; Region: Flavoprotein; cl08021 266264009269 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 266264009270 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266264009271 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266264009272 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266264009273 trimer interface [polypeptide binding]; other site 266264009274 active site 266264009275 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266264009276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264009277 NMT1-like family; Region: NMT1_2; cl15260 266264009278 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 266264009279 Clp amino terminal domain; Region: Clp_N; pfam02861 266264009280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264009281 Walker A motif; other site 266264009282 ATP binding site [chemical binding]; other site 266264009283 Walker B motif; other site 266264009284 arginine finger; other site 266264009285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264009286 Walker A motif; other site 266264009287 ATP binding site [chemical binding]; other site 266264009288 Walker B motif; other site 266264009289 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 266264009290 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 266264009291 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266264009292 DNA-binding site [nucleotide binding]; DNA binding site 266264009293 RNA-binding motif; other site 266264009294 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 266264009295 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 266264009296 pseudouridine synthase; Region: TIGR00093 266264009297 active site 266264009298 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 266264009299 Protein of unknown function (DUF520); Region: DUF520; cl00723 266264009300 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 266264009301 FAD binding domain; Region: FAD_binding_4; pfam01565 266264009302 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 266264009303 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 266264009304 ornithine carbamoyltransferase; Provisional; Region: PRK00779 266264009305 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266264009306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009307 conserved hypothetical protein 266264009308 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 266264009309 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 266264009310 Uncharacterized conserved protein [Function unknown]; Region: COG2912 266264009311 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 266264009312 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266264009313 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266264009314 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 266264009315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264009316 ATP binding site [chemical binding]; other site 266264009317 Mg2+ binding site [ion binding]; other site 266264009318 G-X-G motif; other site 266264009319 Domain of unknown function (DUF3328); Region: DUF3328; pfam11807 266264009320 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 266264009321 ATP binding site [chemical binding]; other site 266264009322 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 266264009323 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 266264009324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264009325 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264009326 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 266264009327 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 266264009328 dimerization interface [polypeptide binding]; other site 266264009329 putative ATP binding site [chemical binding]; other site 266264009330 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264009331 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 266264009332 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266264009333 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264009334 poly(A) polymerase; Region: pcnB; TIGR01942 266264009335 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266264009336 active site 266264009337 NTP binding site [chemical binding]; other site 266264009338 metal binding triad [ion binding]; metal-binding site 266264009339 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266264009340 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 266264009341 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 266264009342 catalytic center binding site [active] 266264009343 ATP binding site [chemical binding]; other site 266264009344 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 266264009345 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 266264009346 Substrate-binding site [chemical binding]; other site 266264009347 Substrate specificity [chemical binding]; other site 266264009348 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 266264009349 oligomerization interface [polypeptide binding]; other site 266264009350 active site 266264009351 metal binding site [ion binding]; metal-binding site 266264009352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264009353 dimer interface [polypeptide binding]; other site 266264009354 conserved gate region; other site 266264009355 putative PBP binding loops; other site 266264009356 ABC-ATPase subunit interface; other site 266264009357 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266264009358 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 266264009359 Walker A/P-loop; other site 266264009360 ATP binding site [chemical binding]; other site 266264009361 Q-loop/lid; other site 266264009362 ABC transporter signature motif; other site 266264009363 Walker B; other site 266264009364 D-loop; other site 266264009365 H-loop/switch region; other site 266264009366 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 266264009367 chorismate binding enzyme; Region: Chorismate_bind; cl10555 266264009368 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 266264009369 homodimer interface [polypeptide binding]; other site 266264009370 substrate-cofactor binding pocket; other site 266264009371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264009372 catalytic residue [active] 266264009373 chaperone protein DnaJ; Provisional; Region: PRK10767 266264009374 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266264009375 HSP70 interaction site [polypeptide binding]; other site 266264009376 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 266264009377 substrate binding site [polypeptide binding]; other site 266264009378 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266264009379 Zn binding sites [ion binding]; other site 266264009380 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266264009381 dimer interface [polypeptide binding]; other site 266264009382 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 266264009383 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 266264009384 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 266264009385 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 266264009386 FAD binding domain; Region: FAD_binding_4; pfam01565 266264009387 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264009388 Helix-turn-helix domains; Region: HTH; cl00088 266264009389 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264009390 dimerization interface [polypeptide binding]; other site 266264009391 substrate binding pocket [chemical binding]; other site 266264009392 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 266264009393 FAD binding domain; Region: FAD_binding_4; pfam01565 266264009394 Ion transport protein; Region: Ion_trans; pfam00520 266264009395 Ion channel; Region: Ion_trans_2; cl11596 266264009396 Double zinc ribbon; Region: DZR; pfam12773 266264009397 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 266264009398 FAD binding domain; Region: FAD_binding_4; pfam01565 266264009399 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 266264009400 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266264009401 Cysteine-rich domain; Region: CCG; pfam02754 266264009402 Cysteine-rich domain; Region: CCG; pfam02754 266264009403 LrgA family; Region: LrgA; cl00608 266264009404 LrgB-like family; Region: LrgB; cl00596 266264009405 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266264009406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264009407 Predicted transcriptional regulator [Transcription]; Region: COG2378 266264009408 Helix-turn-helix domains; Region: HTH; cl00088 266264009409 WYL domain; Region: WYL; cl14852 266264009410 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 266264009411 catalytic residues [active] 266264009412 dimer interface [polypeptide binding]; other site 266264009413 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 266264009414 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 266264009415 Walker A motif; other site 266264009416 ATP binding site [chemical binding]; other site 266264009417 Walker B motif; other site 266264009418 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 266264009419 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 266264009420 Walker A motif; other site 266264009421 ATP binding site [chemical binding]; other site 266264009422 Walker B motif; other site 266264009423 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 266264009424 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264009425 catalytic residue [active] 266264009426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009427 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 266264009428 UbiA prenyltransferase family; Region: UbiA; cl00337 266264009429 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 266264009430 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 266264009431 dimerization interface [polypeptide binding]; other site 266264009432 DPS ferroxidase diiron center [ion binding]; other site 266264009433 ion pore; other site 266264009434 conserved hypothetical protein 266264009435 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 266264009436 Helix-turn-helix domains; Region: HTH; cl00088 266264009437 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 266264009438 dimerization interface [polypeptide binding]; other site 266264009439 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 266264009440 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 266264009441 generic binding surface II; other site 266264009442 ssDNA binding site; other site 266264009443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264009444 ATP binding site [chemical binding]; other site 266264009445 putative Mg++ binding site [ion binding]; other site 266264009446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264009447 nucleotide binding region [chemical binding]; other site 266264009448 ATP-binding site [chemical binding]; other site 266264009449 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 266264009450 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 266264009451 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 266264009452 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 266264009453 Preprotein translocase subunit; Region: YajC; cl00806 266264009454 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 266264009455 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 266264009456 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 266264009457 Protein export membrane protein; Region: SecD_SecF; cl14618 266264009458 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 266264009459 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 266264009460 Protein export membrane protein; Region: SecD_SecF; cl14618 266264009461 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264009462 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264009463 Response regulator receiver domain; Region: Response_reg; pfam00072 266264009464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009465 active site 266264009466 phosphorylation site [posttranslational modification] 266264009467 intermolecular recognition site; other site 266264009468 dimerization interface [polypeptide binding]; other site 266264009469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009470 active site 266264009471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264009472 phosphorylation site [posttranslational modification] 266264009473 intermolecular recognition site; other site 266264009474 dimerization interface [polypeptide binding]; other site 266264009475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264009476 dimer interface [polypeptide binding]; other site 266264009477 phosphorylation site [posttranslational modification] 266264009478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264009479 ATP binding site [chemical binding]; other site 266264009480 Mg2+ binding site [ion binding]; other site 266264009481 G-X-G motif; other site 266264009482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266264009483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264009484 dimer interface [polypeptide binding]; other site 266264009485 phosphorylation site [posttranslational modification] 266264009486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264009487 ATP binding site [chemical binding]; other site 266264009488 Mg2+ binding site [ion binding]; other site 266264009489 G-X-G motif; other site 266264009490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264009491 YceI-like domain; Region: YceI; cl01001 266264009492 YceI-like domain; Region: YceI; cl01001 266264009493 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266264009494 adenylosuccinate lyase; Provisional; Region: PRK09285 266264009495 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 266264009496 tetramer interface [polypeptide binding]; other site 266264009497 active site 266264009498 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase 266264009499 putative glutathione S-transferase; Provisional; Region: PRK10357 266264009500 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 266264009501 putative C-terminal domain interface [polypeptide binding]; other site 266264009502 putative GSH binding site (G-site) [chemical binding]; other site 266264009503 putative dimer interface [polypeptide binding]; other site 266264009504 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 266264009505 dimer interface [polypeptide binding]; other site 266264009506 N-terminal domain interface [polypeptide binding]; other site 266264009507 putative substrate binding pocket (H-site) [chemical binding]; other site 266264009508 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 266264009509 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 266264009510 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 266264009511 nudix motif; other site 266264009512 Dihydrodipicolinate synthase (Fragment) 266264009513 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 266264009514 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 266264009515 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 266264009516 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266264009517 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 266264009518 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 266264009519 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 266264009520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009521 active site 266264009522 phosphorylation site [posttranslational modification] 266264009523 intermolecular recognition site; other site 266264009524 dimerization interface [polypeptide binding]; other site 266264009525 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 266264009526 THUMP domain; Region: THUMP; cl12076 266264009527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264009528 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 266264009529 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 266264009530 putative catalytic residue [active] 266264009531 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 266264009532 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 266264009533 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 266264009534 putative catalytic cysteine [active] 266264009535 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 266264009536 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 266264009537 Lipopolysaccharide-assembly; Region: LptE; cl01125 266264009538 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 266264009539 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 266264009540 HIGH motif; other site 266264009541 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266264009542 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264009543 active site 266264009544 KMSKS motif; other site 266264009545 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 266264009546 tRNA binding surface [nucleotide binding]; other site 266264009547 dihydrodipicolinate reductase; Provisional; Region: PRK00048 266264009548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009549 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266264009550 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 266264009551 ferric uptake regulator; Provisional; Region: fur; PRK09462 266264009552 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266264009553 metal binding site 2 [ion binding]; metal-binding site 266264009554 putative DNA binding helix; other site 266264009555 metal binding site 1 [ion binding]; metal-binding site 266264009556 dimer interface [polypeptide binding]; other site 266264009557 structural Zn2+ binding site [ion binding]; other site 266264009558 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 266264009559 Helix-turn-helix domains; Region: HTH; cl00088 266264009560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264009561 dimerization interface [polypeptide binding]; other site 266264009562 Flavin Reductases; Region: FlaRed; cl00801 266264009563 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 266264009564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009565 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 266264009566 transketolase; Reviewed; Region: PRK12753 266264009567 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266264009568 TPP-binding site [chemical binding]; other site 266264009569 dimer interface [polypeptide binding]; other site 266264009570 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266264009571 PYR/PP interface [polypeptide binding]; other site 266264009572 dimer interface [polypeptide binding]; other site 266264009573 TPP binding site [chemical binding]; other site 266264009574 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266264009575 spermidine synthase; Provisional; Region: PRK00811 266264009576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264009577 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 266264009578 putative dimer interface [polypeptide binding]; other site 266264009579 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264009580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 266264009581 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 266264009582 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 266264009583 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 266264009584 putative RNAase interaction site [polypeptide binding]; other site 266264009585 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 266264009586 active site 266264009587 barstar interaction site; other site 266264009588 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 266264009589 FAD binding site [chemical binding]; other site 266264009590 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266264009591 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264009592 Helix-turn-helix domains; Region: HTH; cl00088 266264009593 putative transposase OrfB; Reviewed; Region: PHA02517 266264009594 HTH-like domain; Region: HTH_21; pfam13276 266264009595 Integrase core domain; Region: rve; cl01316 266264009596 Integrase core domain; Region: rve_3; cl15866 266264009597 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266264009598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009599 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 266264009600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264009601 dimer interface [polypeptide binding]; other site 266264009602 conserved gate region; other site 266264009603 ABC-ATPase subunit interface; other site 266264009604 NMT1-like family; Region: NMT1_2; cl15260 266264009605 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 266264009606 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 266264009607 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 266264009608 Walker A/P-loop; other site 266264009609 ATP binding site [chemical binding]; other site 266264009610 Q-loop/lid; other site 266264009611 ABC transporter signature motif; other site 266264009612 Walker B; other site 266264009613 D-loop; other site 266264009614 H-loop/switch region; other site 266264009615 Helix-turn-helix domains; Region: HTH; cl00088 266264009616 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 266264009617 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264009618 dimerization interface [polypeptide binding]; other site 266264009619 LysE type translocator; Region: LysE; cl00565 266264009620 transposase (fragment) Tn3 family 266264009621 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 266264009622 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 266264009623 active site 266264009624 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 266264009625 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264009626 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264009627 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264009628 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264009629 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264009630 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264009631 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264009632 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264009633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009634 active site 266264009635 phosphorylation site [posttranslational modification] 266264009636 intermolecular recognition site; other site 266264009637 dimerization interface [polypeptide binding]; other site 266264009638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264009639 DNA binding site [nucleotide binding] 266264009640 sensor protein QseC; Provisional; Region: PRK10337 266264009641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264009642 dimer interface [polypeptide binding]; other site 266264009643 phosphorylation site [posttranslational modification] 266264009644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264009645 ATP binding site [chemical binding]; other site 266264009646 Mg2+ binding site [ion binding]; other site 266264009647 G-X-G motif; other site 266264009648 EamA-like transporter family; Region: EamA; cl01037 266264009649 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264009650 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264009651 catalytic residues [active] 266264009652 catalytic nucleophile [active] 266264009653 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264009654 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264009655 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264009656 Synaptic Site I dimer interface [polypeptide binding]; other site 266264009657 DNA binding site [nucleotide binding] 266264009658 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264009659 DNA-binding interface [nucleotide binding]; DNA binding site 266264009660 TniQ; Region: TniQ; pfam06527 266264009661 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264009662 Integrase core domain; Region: rve; cl01316 266264009663 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266264009664 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264009665 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264009666 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264009667 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264009668 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266264009669 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 266264009670 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264009671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264009672 dimer interface [polypeptide binding]; other site 266264009673 phosphorylation site [posttranslational modification] 266264009674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 266264009675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264009676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009677 active site 266264009678 phosphorylation site [posttranslational modification] 266264009679 intermolecular recognition site; other site 266264009680 dimerization interface [polypeptide binding]; other site 266264009681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264009682 DNA binding site [nucleotide binding] 266264009683 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 266264009684 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 266264009685 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 266264009686 FAD binding pocket [chemical binding]; other site 266264009687 FAD binding motif [chemical binding]; other site 266264009688 phosphate binding motif [ion binding]; other site 266264009689 beta-alpha-beta structure motif; other site 266264009690 NAD binding pocket [chemical binding]; other site 266264009691 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 266264009692 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266264009693 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 266264009694 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266264009695 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266264009696 ParA-like protein; Provisional; Region: PHA02518 266264009697 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264009698 P-loop; other site 266264009699 Magnesium ion binding site [ion binding]; other site 266264009700 Replication initiator protein A; Region: RPA; cl02339 266264009701 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264009702 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 266264009703 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266264009704 hypothetical protein 266264009705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264009706 non-specific DNA binding site [nucleotide binding]; other site 266264009707 salt bridge; other site 266264009708 sequence-specific DNA binding site [nucleotide binding]; other site 266264009709 Protein of unknown function (DUF736); Region: DUF736; cl02303 266264009710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264009711 Coenzyme A binding pocket [chemical binding]; other site 266264009712 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 266264009713 ParB-like nuclease domain; Region: ParBc; cl02129 266264009714 Domain of unknown function (DUF932); Region: DUF932; cl12129 266264009715 conserved hypothetical protein 266264009716 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266264009717 Predicted hydrolase (metallo-beta-lactamase superfamily) 266264009718 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 266264009719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009720 ATP binding site [chemical binding]; other site 266264009721 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 266264009722 Predicted transcriptional regulator [Transcription]; Region: COG2378 266264009723 WYL domain; Region: WYL; cl14852 266264009724 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 266264009725 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 266264009726 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264009727 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266264009728 active site 266264009729 DNA binding site [nucleotide binding] 266264009730 Int/Topo IB signature motif; other site 266264009731 Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434 266264009732 malic enzyme; Reviewed; Region: PRK12862 266264009733 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266264009734 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266264009735 putative NAD(P) binding site [chemical binding]; other site 266264009736 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 266264009737 thiamine monophosphate kinase; Provisional; Region: PRK05731 266264009738 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 266264009739 ATP binding site [chemical binding]; other site 266264009740 dimerization interface [polypeptide binding]; other site 266264009741 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 266264009742 tetramer interfaces [polypeptide binding]; other site 266264009743 binuclear metal-binding site [ion binding]; other site 266264009744 Competence-damaged protein; Region: CinA; cl00666 266264009745 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 266264009746 active site 266264009747 dimer interface [polypeptide binding]; other site 266264009748 EamA-like transporter family; Region: EamA; cl01037 266264009749 EamA-like transporter family; Region: EamA; cl01037 266264009750 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266264009751 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 266264009752 Transglycosylase; Region: Transgly; cl07896 266264009753 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 266264009754 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266264009755 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266264009756 shikimate binding site; other site 266264009757 NAD(P) binding site [chemical binding]; other site 266264009758 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266264009759 Gram-negative bacterial tonB protein; Region: TonB; cl10048 266264009760 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 266264009761 RNB domain; Region: RNB; pfam00773 266264009762 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 266264009763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009764 NAD(P) binding site [chemical binding]; other site 266264009765 active site 266264009766 UTRA domain; Region: UTRA; cl01230 266264009767 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 266264009768 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 266264009769 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266264009770 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264009771 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264009772 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266264009773 catalytic residues [active] 266264009774 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 266264009775 trimer interface [polypeptide binding]; other site 266264009776 active site 266264009777 dimer interface [polypeptide binding]; other site 266264009778 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 266264009779 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264009780 carboxyltransferase (CT) interaction site; other site 266264009781 biotinylation site [posttranslational modification]; other site 266264009782 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266264009783 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264009784 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264009785 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266264009786 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 266264009787 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266264009788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264009789 S-adenosylmethionine binding site [chemical binding]; other site 266264009790 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 266264009791 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 266264009792 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 266264009793 dimer interface [polypeptide binding]; other site 266264009794 catalytic triad [active] 266264009795 peroxidatic and resolving cysteines [active] 266264009796 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266264009797 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 266264009798 substrate binding site [chemical binding]; other site 266264009799 ATP binding site [chemical binding]; other site 266264009800 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 266264009801 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 266264009802 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 266264009803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264009804 NMT1-like family; Region: NMT1_2; cl15260 266264009805 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 266264009806 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264009807 N-terminal plug; other site 266264009808 ligand-binding site [chemical binding]; other site 266264009809 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264009810 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 266264009811 Helix-turn-helix domains; Region: HTH; cl00088 266264009812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264009813 dimerization interface [polypeptide binding]; other site 266264009814 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266264009815 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264009816 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264009817 active site 266264009818 catalytic tetrad [active] 266264009819 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 266264009820 putative amphipathic alpha helix; other site 266264009821 Putative exonuclease, RdgC; Region: RdgC; cl01122 266264009822 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266264009823 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266264009824 putative NAD(P) binding site [chemical binding]; other site 266264009825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264009826 NMT1-like family; Region: NMT1_2; cl15260 266264009827 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 266264009828 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 266264009829 dimer interface [polypeptide binding]; other site 266264009830 putative radical transfer pathway; other site 266264009831 diiron center [ion binding]; other site 266264009832 tyrosyl radical; other site 266264009833 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 266264009834 ATP cone domain; Region: ATP-cone; pfam03477 266264009835 Class I ribonucleotide reductase; Region: RNR_I; cd01679 266264009836 active site 266264009837 dimer interface [polypeptide binding]; other site 266264009838 catalytic residues [active] 266264009839 effector binding site; other site 266264009840 R2 peptide binding site; other site 266264009841 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 266264009842 amidase catalytic site [active] 266264009843 Zn binding residues [ion binding]; other site 266264009844 substrate binding site [chemical binding]; other site 266264009845 Response regulator receiver domain; Region: Response_reg; pfam00072 266264009846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009847 active site 266264009848 phosphorylation site [posttranslational modification] 266264009849 intermolecular recognition site; other site 266264009850 dimerization interface [polypeptide binding]; other site 266264009851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264009852 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264009853 Walker A motif; other site 266264009854 ATP binding site [chemical binding]; other site 266264009855 Walker B motif; other site 266264009856 arginine finger; other site 266264009857 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 266264009858 Helix-turn-helix domains; Region: HTH; cl00088 266264009859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264009860 dimer interface [polypeptide binding]; other site 266264009861 phosphorylation site [posttranslational modification] 266264009862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264009863 ATP binding site [chemical binding]; other site 266264009864 Mg2+ binding site [ion binding]; other site 266264009865 G-X-G motif; other site 266264009866 FHIPEP family; Region: FHIPEP; pfam00771 266264009867 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266264009868 signal recognition particle protein; Provisional; Region: PRK10867 266264009869 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 266264009870 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266264009871 P loop; other site 266264009872 GTP binding site [chemical binding]; other site 266264009873 Signal peptide binding domain; Region: SRP_SPB; pfam02978 266264009874 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264009875 active site 266264009876 LysE type translocator; Region: LysE; cl00565 266264009877 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266264009878 active site 266264009879 substrate binding sites [chemical binding]; other site 266264009880 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 266264009881 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264009882 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266264009883 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264009884 catalytic residue [active] 266264009885 prolyl-tRNA synthetase; Provisional; Region: PRK09194 266264009886 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 266264009887 dimer interface [polypeptide binding]; other site 266264009888 motif 1; other site 266264009889 active site 266264009890 motif 2; other site 266264009891 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 266264009892 putative deacylase active site [active] 266264009893 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 266264009894 active site 266264009895 motif 3; other site 266264009896 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 266264009897 anticodon binding site; other site 266264009898 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 266264009899 putative active site [active] 266264009900 Ap4A binding site [chemical binding]; other site 266264009901 nudix motif; other site 266264009902 putative metal binding site [ion binding]; other site 266264009903 CNP1-like family; Region: CNP1; pfam08750 266264009904 gamma-glutamyl kinase; Provisional; Region: PRK05429 266264009905 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 266264009906 nucleotide binding site [chemical binding]; other site 266264009907 homotetrameric interface [polypeptide binding]; other site 266264009908 putative phosphate binding site [ion binding]; other site 266264009909 putative allosteric binding site; other site 266264009910 PUA domain; Region: PUA; cl00607 266264009911 GTPase CgtA; Reviewed; Region: obgE; PRK12299 266264009912 GTP1/OBG; Region: GTP1_OBG; pfam01018 266264009913 Obg GTPase; Region: Obg; cd01898 266264009914 G1 box; other site 266264009915 GTP/Mg2+ binding site [chemical binding]; other site 266264009916 Switch I region; other site 266264009917 G2 box; other site 266264009918 G3 box; other site 266264009919 Switch II region; other site 266264009920 G4 box; other site 266264009921 G5 box; other site 266264009922 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 266264009923 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 266264009924 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266264009925 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266264009926 substrate binding pocket [chemical binding]; other site 266264009927 chain length determination region; other site 266264009928 substrate-Mg2+ binding site; other site 266264009929 catalytic residues [active] 266264009930 aspartate-rich region 1; other site 266264009931 active site lid residues [active] 266264009932 aspartate-rich region 2; other site 266264009933 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 266264009934 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 266264009935 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266264009936 Walker A motif; other site 266264009937 ATP binding site [chemical binding]; other site 266264009938 Walker B motif; other site 266264009939 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266264009940 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264009941 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264009942 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 266264009943 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 266264009944 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 266264009945 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 266264009946 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 266264009947 CoA-binding site [chemical binding]; other site 266264009948 ATP-binding [chemical binding]; other site 266264009949 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 266264009950 Domain of unknown function (DUF329); Region: DUF329; cl01144 266264009951 OPT oligopeptide transporter protein; Region: OPT; cl14607 266264009952 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 266264009953 active site 266264009954 8-oxo-dGMP binding site [chemical binding]; other site 266264009955 nudix motif; other site 266264009956 metal binding site [ion binding]; metal-binding site 266264009957 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 266264009958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264009959 Walker A motif; other site 266264009960 ATP binding site [chemical binding]; other site 266264009961 Walker B motif; other site 266264009962 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 266264009963 heterotetramer interface [polypeptide binding]; other site 266264009964 active site pocket [active] 266264009965 cleavage site 266264009966 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 266264009967 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 266264009968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264009969 nucleotide binding region [chemical binding]; other site 266264009970 ATP-binding site [chemical binding]; other site 266264009971 SEC-C motif; Region: SEC-C; pfam02810 266264009972 Peptidase family M23; Region: Peptidase_M23; pfam01551 266264009973 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 266264009974 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 266264009975 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 266264009976 catalytic triad [active] 266264009977 dimer interface [polypeptide binding]; other site 266264009978 cell division protein FtsZ; Validated; Region: PRK09330 266264009979 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 266264009980 nucleotide binding site [chemical binding]; other site 266264009981 SulA interaction site; other site 266264009982 cell division protein FtsA; Region: ftsA; TIGR01174 266264009983 Cell division protein FtsA; Region: FtsA; cl11496 266264009984 Cell division protein FtsA; Region: FtsA; cl11496 266264009985 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266264009986 Cell division protein FtsQ; Region: FtsQ; pfam03799 266264009987 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 266264009988 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266264009989 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264009990 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 266264009991 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266264009992 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264009993 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264009994 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 266264009995 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 266264009996 active site 266264009997 homodimer interface [polypeptide binding]; other site 266264009998 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 266264009999 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 266264010000 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264010001 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264010002 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 266264010003 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 266264010004 Mg++ binding site [ion binding]; other site 266264010005 putative catalytic motif [active] 266264010006 putative substrate binding site [chemical binding]; other site 266264010007 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 266264010008 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266264010009 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264010010 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264010011 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 266264010012 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266264010013 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264010014 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264010015 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266264010016 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266264010017 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264010018 Septum formation initiator; Region: DivIC; cl11433 266264010019 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 266264010020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264010021 MraZ protein; Region: MraZ; pfam02381 266264010022 cell division protein MraZ; Reviewed; Region: PRK00326 266264010023 MraZ protein; Region: MraZ; pfam02381 266264010024 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 266264010025 diiron binding motif [ion binding]; other site 266264010026 outer membrane protein (porin) (fragment) 266264010027 AAA domain; Region: AAA_22; pfam13401 266264010028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264010029 Walker A motif; other site 266264010030 ATP binding site [chemical binding]; other site 266264010031 Walker B motif; other site 266264010032 arginine finger; other site 266264010033 Integrase core domain; Region: rve; cl01316 266264010034 outer membrane protein (porin) 266264010035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264010036 NMT1-like family; Region: NMT1_2; cl15260 266264010037 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264010038 Helix-turn-helix domains; Region: HTH; cl00088 266264010039 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 266264010040 AMP-binding enzyme; Region: AMP-binding; cl15778 266264010041 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264010042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264010043 Helix-turn-helix domains; Region: HTH; cl00088 266264010044 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 266264010045 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266264010046 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 266264010047 putative [4Fe-4S] binding site [ion binding]; other site 266264010048 putative molybdopterin cofactor binding site [chemical binding]; other site 266264010049 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 266264010050 putative molybdopterin cofactor binding site; other site 266264010051 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264010052 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 266264010053 putative ligand binding site [chemical binding]; other site 266264010054 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266264010055 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264010056 Walker A/P-loop; other site 266264010057 ATP binding site [chemical binding]; other site 266264010058 Q-loop/lid; other site 266264010059 ABC transporter signature motif; other site 266264010060 Walker B; other site 266264010061 D-loop; other site 266264010062 H-loop/switch region; other site 266264010063 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264010064 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266264010065 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264010066 Walker A/P-loop; other site 266264010067 ATP binding site [chemical binding]; other site 266264010068 Q-loop/lid; other site 266264010069 ABC transporter signature motif; other site 266264010070 Walker B; other site 266264010071 D-loop; other site 266264010072 H-loop/switch region; other site 266264010073 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264010074 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266264010075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264010076 putative PBP binding loops; other site 266264010077 ABC-ATPase subunit interface; other site 266264010078 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266264010079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264010080 dimer interface [polypeptide binding]; other site 266264010081 conserved gate region; other site 266264010082 putative PBP binding loops; other site 266264010083 ABC-ATPase subunit interface; other site 266264010084 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 266264010085 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266264010086 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266264010087 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266264010088 metal binding site [ion binding]; metal-binding site 266264010089 putative dimer interface [polypeptide binding]; other site 266264010090 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 266264010091 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 266264010092 hypothetical protein 266264010093 enoyl-CoA hydratase; Provisional; Region: PRK05862 266264010094 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264010095 substrate binding site [chemical binding]; other site 266264010096 oxyanion hole (OAH) forming residues; other site 266264010097 trimer interface [polypeptide binding]; other site 266264010098 enoyl-CoA hydratase; Provisional; Region: PRK08140 266264010099 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264010100 substrate binding site [chemical binding]; other site 266264010101 oxyanion hole (OAH) forming residues; other site 266264010102 trimer interface [polypeptide binding]; other site 266264010103 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264010104 CoenzymeA binding site [chemical binding]; other site 266264010105 subunit interaction site [polypeptide binding]; other site 266264010106 PHB binding site; other site 266264010107 AMP-binding enzyme; Region: AMP-binding; cl15778 266264010108 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 266264010109 AMP-binding enzyme; Region: AMP-binding; cl15778 266264010110 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 266264010111 GAF domain; Region: GAF; cl15785 266264010112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264010113 Walker A motif; other site 266264010114 ATP binding site [chemical binding]; other site 266264010115 Walker B motif; other site 266264010116 arginine finger; other site 266264010117 Helix-turn-helix domains; Region: HTH; cl00088 266264010118 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 266264010119 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 266264010120 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 266264010121 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 266264010122 Cytochrome c; Region: Cytochrom_C; cl11414 266264010123 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 266264010124 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266264010125 structural tetrad; other site 266264010126 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 266264010127 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264010128 FeS/SAM binding site; other site 266264010129 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 266264010130 Cytochrome c; Region: Cytochrom_C; cl11414 266264010131 Cytochrome c; Region: Cytochrom_C; cl11414 266264010132 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 266264010133 MltA specific insert domain; Region: MltA; cl08398 266264010134 3D domain; Region: 3D; cl01439 266264010135 Protein of unknown function (DUF525); Region: DUF525; cl01119 266264010136 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266264010137 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 266264010138 substrate binding site [chemical binding]; other site 266264010139 hexamer interface [polypeptide binding]; other site 266264010140 metal binding site [ion binding]; metal-binding site 266264010141 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 266264010142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264010143 motif II; other site 266264010144 anthranilate synthase component I; Provisional; Region: PRK13565 266264010145 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 266264010146 chorismate binding enzyme; Region: Chorismate_bind; cl10555 266264010147 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 266264010148 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 266264010149 glutamine binding [chemical binding]; other site 266264010150 catalytic triad [active] 266264010151 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 266264010152 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266264010153 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266264010154 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 266264010155 active site 266264010156 ribulose/triose binding site [chemical binding]; other site 266264010157 phosphate binding site [ion binding]; other site 266264010158 substrate (anthranilate) binding pocket [chemical binding]; other site 266264010159 product (indole) binding pocket [chemical binding]; other site 266264010160 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 266264010161 putative active site [active] 266264010162 putative triphosphate binding site [ion binding]; other site 266264010163 putative metal binding residues [ion binding]; other site 266264010164 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 266264010165 ligand binding site [chemical binding]; other site 266264010166 active site 266264010167 UGI interface [polypeptide binding]; other site 266264010168 catalytic site [active] 266264010169 Acylphosphatase; Region: Acylphosphatase; cl00551 266264010170 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 266264010171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264010172 dimer interface [polypeptide binding]; other site 266264010173 conserved gate region; other site 266264010174 putative PBP binding loops; other site 266264010175 ABC-ATPase subunit interface; other site 266264010176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264010177 dimer interface [polypeptide binding]; other site 266264010178 conserved gate region; other site 266264010179 putative PBP binding loops; other site 266264010180 ABC-ATPase subunit interface; other site 266264010181 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264010182 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266264010183 Walker A/P-loop; other site 266264010184 ATP binding site [chemical binding]; other site 266264010185 Q-loop/lid; other site 266264010186 ABC transporter signature motif; other site 266264010187 Walker B; other site 266264010188 D-loop; other site 266264010189 H-loop/switch region; other site 266264010190 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 266264010191 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 266264010192 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 266264010193 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 266264010194 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 266264010195 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 266264010196 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 266264010197 protein binding site [polypeptide binding]; other site 266264010198 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 266264010199 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 266264010200 NADP binding site [chemical binding]; other site 266264010201 dimer interface [polypeptide binding]; other site 266264010202 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 266264010203 dimerization domain [polypeptide binding]; other site 266264010204 dimer interface [polypeptide binding]; other site 266264010205 catalytic residues [active] 266264010206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264010207 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266264010208 Putative membrane protein (fragment) PAP2 family protein 266264010209 GTP-binding protein YchF; Reviewed; Region: PRK09601 266264010210 YchF GTPase; Region: YchF; cd01900 266264010211 G1 box; other site 266264010212 GTP/Mg2+ binding site [chemical binding]; other site 266264010213 Switch I region; other site 266264010214 G2 box; other site 266264010215 Switch II region; other site 266264010216 G3 box; other site 266264010217 G4 box; other site 266264010218 G5 box; other site 266264010219 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 266264010220 GDYXXLXY protein; Region: GDYXXLXY; cl02066 266264010221 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 266264010222 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 266264010223 Predicted membrane protein [Function unknown]; Region: COG4984 266264010224 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 266264010225 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 266264010226 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 266264010227 tRNA; other site 266264010228 putative tRNA binding site [nucleotide binding]; other site 266264010229 putative NADP binding site [chemical binding]; other site 266264010230 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 266264010231 peptide chain release factor 1; Validated; Region: prfA; PRK00591 266264010232 RF-1 domain; Region: RF-1; cl02875 266264010233 RF-1 domain; Region: RF-1; cl02875 266264010234 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 266264010235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264010236 S-adenosylmethionine binding site [chemical binding]; other site 266264010237 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 266264010238 putative GSH binding site [chemical binding]; other site 266264010239 catalytic residues [active] 266264010240 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 266264010241 Flavoprotein; Region: Flavoprotein; cl08021 266264010242 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264010243 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266264010244 NAD(P) binding site [chemical binding]; other site 266264010245 catalytic residues [active] 266264010246 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 266264010247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264010248 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264010249 Helix-turn-helix domains; Region: HTH; cl00088 266264010250 AsnC family; Region: AsnC_trans_reg; pfam01037 266264010251 dihydrodipicolinate reductase; Provisional; Region: PRK00048 266264010252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264010253 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266264010254 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 266264010255 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 266264010256 putative ion selectivity filter; other site 266264010257 putative pore gating glutamate residue; other site 266264010258 putative H+/Cl- coupling transport residue; other site 266264010259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264010260 NMT1-like family; Region: NMT1_2; cl15260 266264010261 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 266264010262 AMP-binding enzyme; Region: AMP-binding; cl15778 266264010263 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264010264 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264010265 Helix-turn-helix domains; Region: HTH; cl00088 266264010266 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264010267 putative effector binding pocket; other site 266264010268 dimerization interface [polypeptide binding]; other site 266264010269 Helix-turn-helix domains; Region: HTH; cl00088 266264010270 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 266264010271 MatE; Region: MatE; cl10513 266264010272 MatE; Region: MatE; cl10513 266264010273 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 266264010274 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 266264010275 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 266264010276 putative active site [active] 266264010277 putative metal binding site [ion binding]; other site 266264010278 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 266264010279 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264010280 Walker A/P-loop; other site 266264010281 ATP binding site [chemical binding]; other site 266264010282 Q-loop/lid; other site 266264010283 ABC transporter signature motif; other site 266264010284 Walker B; other site 266264010285 D-loop; other site 266264010286 H-loop/switch region; other site 266264010287 ABC transporter; Region: ABC_tran_2; pfam12848 266264010288 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264010289 Protein of unknown function DUF45; Region: DUF45; cl00636 266264010290 TM1410 hypothetical-related protein; Region: DUF297; cl00997 266264010291 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264010292 metal binding site [ion binding]; metal-binding site 266264010293 active site 266264010294 I-site; other site 266264010295 Stringent starvation protein B; Region: SspB; cl01120 266264010296 stringent starvation protein A; Provisional; Region: sspA; PRK09481 266264010297 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 266264010298 C-terminal domain interface [polypeptide binding]; other site 266264010299 putative GSH binding site (G-site) [chemical binding]; other site 266264010300 dimer interface [polypeptide binding]; other site 266264010301 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 266264010302 dimer interface [polypeptide binding]; other site 266264010303 N-terminal domain interface [polypeptide binding]; other site 266264010304 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 266264010305 cytochrome b; Provisional; Region: CYTB; MTH00145 266264010306 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 266264010307 Qi binding site; other site 266264010308 intrachain domain interface; other site 266264010309 interchain domain interface [polypeptide binding]; other site 266264010310 heme bH binding site [chemical binding]; other site 266264010311 heme bL binding site [chemical binding]; other site 266264010312 Qo binding site; other site 266264010313 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 266264010314 interchain domain interface [polypeptide binding]; other site 266264010315 intrachain domain interface; other site 266264010316 Qi binding site; other site 266264010317 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 266264010318 Qo binding site; other site 266264010319 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 266264010320 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 266264010321 [2Fe-2S] cluster binding site [ion binding]; other site 266264010322 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 266264010323 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 266264010324 Uncharacterized conserved protein [Function unknown]; Region: COG0327 266264010325 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 266264010326 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266264010327 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266264010328 protein binding site [polypeptide binding]; other site 266264010329 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264010330 trimer interface [polypeptide binding]; other site 266264010331 eyelet of channel; other site 266264010332 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 266264010333 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 266264010334 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 266264010335 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 266264010336 nucleotide binding site/active site [active] 266264010337 HIT family signature motif; other site 266264010338 catalytic residue [active] 266264010339 Predicted membrane protein [Function unknown]; Region: COG3671 266264010340 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 266264010341 metal binding site [ion binding]; metal-binding site 266264010342 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 266264010343 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 266264010344 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266264010345 substrate binding site [chemical binding]; other site 266264010346 glutamase interaction surface [polypeptide binding]; other site 266264010347 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 266264010348 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 266264010349 catalytic residues [active] 266264010350 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 266264010351 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 266264010352 putative active site [active] 266264010353 oxyanion strand; other site 266264010354 catalytic triad [active] 266264010355 MarC family integral membrane protein; Region: MarC; cl00919 266264010356 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 266264010357 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 266264010358 putative active site pocket [active] 266264010359 4-fold oligomerization interface [polypeptide binding]; other site 266264010360 metal binding residues [ion binding]; metal-binding site 266264010361 3-fold/trimer interface [polypeptide binding]; other site 266264010362 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 266264010363 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264010364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264010365 homodimer interface [polypeptide binding]; other site 266264010366 catalytic residue [active] 266264010367 histidinol dehydrogenase; Region: hisD; TIGR00069 266264010368 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266264010369 NAD binding site [chemical binding]; other site 266264010370 dimerization interface [polypeptide binding]; other site 266264010371 product binding site; other site 266264010372 substrate binding site [chemical binding]; other site 266264010373 zinc binding site [ion binding]; other site 266264010374 catalytic residues [active] 266264010375 ATP phosphoribosyltransferase; Region: HisG; cl15266 266264010376 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 266264010377 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 266264010378 hinge; other site 266264010379 active site 266264010380 BolA-like protein; Region: BolA; cl00386 266264010381 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266264010382 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266264010383 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 266264010384 Walker A/P-loop; other site 266264010385 ATP binding site [chemical binding]; other site 266264010386 Q-loop/lid; other site 266264010387 ABC transporter signature motif; other site 266264010388 Walker B; other site 266264010389 D-loop; other site 266264010390 H-loop/switch region; other site 266264010391 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266264010392 anti sigma factor interaction site; other site 266264010393 regulatory phosphorylation site [posttranslational modification]; other site 266264010394 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 266264010395 VacJ like lipoprotein; Region: VacJ; cl01073 266264010396 mce related protein; Region: MCE; pfam02470 266264010397 Permease; Region: Permease; cl00510 266264010398 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 266264010399 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 266264010400 Walker A/P-loop; other site 266264010401 ATP binding site [chemical binding]; other site 266264010402 Q-loop/lid; other site 266264010403 ABC transporter signature motif; other site 266264010404 Walker B; other site 266264010405 D-loop; other site 266264010406 H-loop/switch region; other site 266264010407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264010408 NMT1-like family; Region: NMT1_2; cl15260 266264010409 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 266264010410 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 266264010411 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 266264010412 active site 266264010413 dimer interface [polypeptide binding]; other site 266264010414 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 266264010415 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266264010416 active site 266264010417 FMN binding site [chemical binding]; other site 266264010418 substrate binding site [chemical binding]; other site 266264010419 3Fe-4S cluster binding site [ion binding]; other site 266264010420 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 266264010421 domain interface; other site 266264010422 Transposase IS200 like; Region: Y1_Tnp; cl00848 266264010423 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 266264010424 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264010425 Zn2+ binding site [ion binding]; other site 266264010426 Mg2+ binding site [ion binding]; other site 266264010427 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 266264010428 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 266264010429 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 266264010430 active site 266264010431 dimer interface [polypeptide binding]; other site 266264010432 metal binding site [ion binding]; metal-binding site 266264010433 shikimate kinase; Reviewed; Region: aroK; PRK00131 266264010434 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266264010435 ADP binding site [chemical binding]; other site 266264010436 magnesium binding site [ion binding]; other site 266264010437 putative shikimate binding site; other site 266264010438 AMIN domain; Region: AMIN; pfam11741 266264010439 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 266264010440 Secretin and TonB N terminus short domain; Region: STN; cl06624 266264010441 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266264010442 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264010443 Pilus assembly protein, PilP; Region: PilP; pfam04351 266264010444 Pilus assembly protein, PilO; Region: PilO; cl01234 266264010445 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 266264010446 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 266264010447 Cell division protein FtsA; Region: FtsA; cl11496 266264010448 Competence protein A; Region: Competence_A; pfam11104 266264010449 Transglycosylase; Region: Transgly; cl07896 266264010450 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264010451 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238 266264010452 putative iron binding site [ion binding]; other site 266264010453 diaminopimelate decarboxylase; Region: lysA; TIGR01048 266264010454 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 266264010455 active site 266264010456 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264010457 substrate binding site [chemical binding]; other site 266264010458 catalytic residues [active] 266264010459 dimer interface [polypeptide binding]; other site 266264010460 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 266264010461 TMAO/DMSO reductase; Reviewed; Region: PRK05363 266264010462 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 266264010463 Moco binding site; other site 266264010464 metal coordination site [ion binding]; other site 266264010465 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266264010466 RNA polymerase sigma factor; Provisional; Region: PRK11924 266264010467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264010468 DNA binding residues [nucleotide binding] 266264010469 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266264010470 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266264010471 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266264010472 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 266264010473 Cytochrome c; Region: Cytochrom_C; cl11414 266264010474 Cytochrome c; Region: Cytochrom_C; cl11414 266264010475 Predicted GTPase [General function prediction only]; Region: COG0218 266264010476 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 266264010477 G1 box; other site 266264010478 GTP/Mg2+ binding site [chemical binding]; other site 266264010479 Switch I region; other site 266264010480 G2 box; other site 266264010481 G3 box; other site 266264010482 Switch II region; other site 266264010483 G4 box; other site 266264010484 G5 box; other site 266264010485 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 266264010486 dimer interface [polypeptide binding]; other site 266264010487 active site 266264010488 aspartate-rich active site metal binding site; other site 266264010489 allosteric magnesium binding site [ion binding]; other site 266264010490 Schiff base residues; other site 266264010491 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 266264010492 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 266264010493 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 266264010494 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 266264010495 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266264010496 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 266264010497 DsbD alpha interface [polypeptide binding]; other site 266264010498 catalytic residues [active] 266264010499 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 266264010500 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 266264010501 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 266264010502 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 266264010503 alphaNTD homodimer interface [polypeptide binding]; other site 266264010504 alphaNTD - beta interaction site [polypeptide binding]; other site 266264010505 alphaNTD - beta' interaction site [polypeptide binding]; other site 266264010506 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 266264010507 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 266264010508 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 266264010509 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264010510 RNA binding surface [nucleotide binding]; other site 266264010511 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 266264010512 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 266264010513 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 266264010514 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 266264010515 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266264010516 rRNA binding site [nucleotide binding]; other site 266264010517 predicted 30S ribosome binding site; other site 266264010518 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 266264010519 SecY translocase; Region: SecY; pfam00344 266264010520 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 266264010521 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 266264010522 23S rRNA binding site [nucleotide binding]; other site 266264010523 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 266264010524 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 266264010525 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 266264010526 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 266264010527 5S rRNA interface [nucleotide binding]; other site 266264010528 23S rRNA interface [nucleotide binding]; other site 266264010529 L5 interface [polypeptide binding]; other site 266264010530 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 266264010531 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266264010532 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266264010533 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 266264010534 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 266264010535 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 266264010536 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 266264010537 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 266264010538 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 266264010539 KOW motif; Region: KOW; cl00354 266264010540 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 266264010541 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 266264010542 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 266264010543 23S rRNA interface [nucleotide binding]; other site 266264010544 putative translocon interaction site; other site 266264010545 signal recognition particle (SRP54) interaction site; other site 266264010546 L23 interface [polypeptide binding]; other site 266264010547 trigger factor interaction site; other site 266264010548 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 266264010549 23S rRNA interface [nucleotide binding]; other site 266264010550 5S rRNA interface [nucleotide binding]; other site 266264010551 putative antibiotic binding site [chemical binding]; other site 266264010552 L25 interface [polypeptide binding]; other site 266264010553 L27 interface [polypeptide binding]; other site 266264010554 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 266264010555 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 266264010556 G-X-X-G motif; other site 266264010557 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 266264010558 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 266264010559 putative translocon binding site; other site 266264010560 protein-rRNA interface [nucleotide binding]; other site 266264010561 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 266264010562 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 266264010563 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 266264010564 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 266264010565 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 266264010566 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 266264010567 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 266264010568 Flavin Reductases; Region: FlaRed; cl00801 266264010569 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266264010570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264010571 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264010572 classical (c) SDRs; Region: SDR_c; cd05233 266264010573 NAD(P) binding site [chemical binding]; other site 266264010574 active site 266264010575 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266264010576 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264010577 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264010578 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264010579 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 266264010580 elongation factor Tu; Reviewed; Region: PRK00049 266264010581 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266264010582 G1 box; other site 266264010583 GEF interaction site [polypeptide binding]; other site 266264010584 GTP/Mg2+ binding site [chemical binding]; other site 266264010585 Switch I region; other site 266264010586 G2 box; other site 266264010587 G3 box; other site 266264010588 Switch II region; other site 266264010589 G4 box; other site 266264010590 G5 box; other site 266264010591 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266264010592 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266264010593 Antibiotic Binding Site [chemical binding]; other site 266264010594 elongation factor G; Reviewed; Region: PRK00007 266264010595 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 266264010596 G1 box; other site 266264010597 putative GEF interaction site [polypeptide binding]; other site 266264010598 GTP/Mg2+ binding site [chemical binding]; other site 266264010599 Switch I region; other site 266264010600 G2 box; other site 266264010601 G3 box; other site 266264010602 Switch II region; other site 266264010603 G4 box; other site 266264010604 G5 box; other site 266264010605 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266264010606 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266264010607 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266264010608 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 266264010609 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 266264010610 S17 interaction site [polypeptide binding]; other site 266264010611 S8 interaction site; other site 266264010612 16S rRNA interaction site [nucleotide binding]; other site 266264010613 streptomycin interaction site [chemical binding]; other site 266264010614 23S rRNA interaction site [nucleotide binding]; other site 266264010615 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 266264010616 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 266264010617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264010618 ATP binding site [chemical binding]; other site 266264010619 putative Mg++ binding site [ion binding]; other site 266264010620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264010621 nucleotide binding region [chemical binding]; other site 266264010622 ATP-binding site [chemical binding]; other site 266264010623 RQC domain; Region: RQC; cl09632 266264010624 HRDC domain; Region: HRDC; cl02578 266264010625 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264010626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264010627 DNA-binding site [nucleotide binding]; DNA binding site 266264010628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264010629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264010630 homodimer interface [polypeptide binding]; other site 266264010631 catalytic residue [active] 266264010632 Cytochrome c; Region: Cytochrom_C; cl11414 266264010633 Cytochrome c; Region: Cytochrom_C; cl11414 266264010634 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 266264010635 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 266264010636 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 266264010637 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 266264010638 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 266264010639 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 266264010640 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 266264010641 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266264010642 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 266264010643 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 266264010644 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266264010645 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 266264010646 DNA binding site [nucleotide binding] 266264010647 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 266264010648 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 266264010649 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 266264010650 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266264010651 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 266264010652 RPB11 interaction site [polypeptide binding]; other site 266264010653 RPB12 interaction site [polypeptide binding]; other site 266264010654 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266264010655 RPB3 interaction site [polypeptide binding]; other site 266264010656 RPB1 interaction site [polypeptide binding]; other site 266264010657 RPB11 interaction site [polypeptide binding]; other site 266264010658 RPB10 interaction site [polypeptide binding]; other site 266264010659 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 266264010660 core dimer interface [polypeptide binding]; other site 266264010661 peripheral dimer interface [polypeptide binding]; other site 266264010662 L10 interface [polypeptide binding]; other site 266264010663 L11 interface [polypeptide binding]; other site 266264010664 putative EF-Tu interaction site [polypeptide binding]; other site 266264010665 putative EF-G interaction site [polypeptide binding]; other site 266264010666 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 266264010667 23S rRNA interface [nucleotide binding]; other site 266264010668 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 266264010669 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 266264010670 mRNA/rRNA interface [nucleotide binding]; other site 266264010671 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 266264010672 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 266264010673 23S rRNA interface [nucleotide binding]; other site 266264010674 L7/L12 interface [polypeptide binding]; other site 266264010675 putative thiostrepton binding site; other site 266264010676 L25 interface [polypeptide binding]; other site 266264010677 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 266264010678 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 266264010679 putative homodimer interface [polypeptide binding]; other site 266264010680 KOW motif; Region: KOW; cl00354 266264010681 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 266264010682 elongation factor Tu; Reviewed; Region: PRK00049 266264010683 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266264010684 G1 box; other site 266264010685 GEF interaction site [polypeptide binding]; other site 266264010686 GTP/Mg2+ binding site [chemical binding]; other site 266264010687 Switch I region; other site 266264010688 G2 box; other site 266264010689 G3 box; other site 266264010690 Switch II region; other site 266264010691 G4 box; other site 266264010692 G5 box; other site 266264010693 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266264010694 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266264010695 Antibiotic Binding Site [chemical binding]; other site 266264010696 Protein of unknown function, DUF488; Region: DUF488; cl01246 266264010697 Nucleoside recognition; Region: Gate; cl00486 266264010698 Nucleoside recognition; Region: Gate; cl00486 266264010699 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 266264010700 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266264010701 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264010702 Ligand Binding Site [chemical binding]; other site 266264010703 Protein of unknown function DUF91; Region: DUF91; cl00709 266264010704 putative transposase OrfB; Reviewed; Region: PHA02517 266264010705 HTH-like domain; Region: HTH_21; pfam13276 266264010706 Integrase core domain; Region: rve; cl01316 266264010707 Integrase core domain; Region: rve_3; cl15866 266264010708 Helix-turn-helix domains; Region: HTH; cl00088 266264010709 LabA_like proteins; Region: LabA_like; cd06167 266264010710 putative metal binding site [ion binding]; other site 266264010711 Cytidine/deoxycytidylate deaminase (fragment) 266264010712 Transposase domain (DUF772); Region: DUF772; pfam05598 266264010713 DDE superfamily endonuclease; Region: DDE_4; cl15789 266264010714 Deoxycytidylate deaminase-related protein (fragment) 266264010715 Helix-turn-helix domains; Region: HTH; cl00088 266264010716 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266264010717 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266264010718 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266264010719 hypothetical protein; Provisional; Region: PRK06153 266264010720 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 266264010721 ATP binding site [chemical binding]; other site 266264010722 substrate interface [chemical binding]; other site 266264010723 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 266264010724 TniQ; Region: TniQ; pfam06527 266264010725 transposase/IS protein; Provisional; Region: PRK09183 266264010726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264010727 Walker A motif; other site 266264010728 ATP binding site [chemical binding]; other site 266264010729 Walker B motif; other site 266264010730 arginine finger; other site 266264010731 Helix-turn-helix domains; Region: HTH; cl00088 266264010732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266264010733 Integrase core domain; Region: rve; cl01316 266264010734 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 266264010735 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 266264010736 putative active site [active] 266264010737 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 266264010738 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264010739 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 266264010740 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 266264010741 Phenylacetic acid degradation B; Region: PaaB; cl01371 266264010742 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 266264010743 Domain of unknown function DUF59; Region: DUF59; cl00941 266264010744 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 266264010745 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 266264010746 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 266264010747 FAD binding pocket [chemical binding]; other site 266264010748 FAD binding motif [chemical binding]; other site 266264010749 phosphate binding motif [ion binding]; other site 266264010750 beta-alpha-beta structure motif; other site 266264010751 NAD(p) ribose binding residues [chemical binding]; other site 266264010752 NAD binding pocket [chemical binding]; other site 266264010753 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 266264010754 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264010755 catalytic loop [active] 266264010756 iron binding site [ion binding]; other site 266264010757 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 266264010758 Protein of unknown function; Region: DUF3658; pfam12395 266264010759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264010760 Helix-turn-helix domains; Region: HTH; cl00088 266264010761 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 266264010762 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266264010763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264010764 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264010765 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264010766 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264010767 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264010768 putative DNA binding site [nucleotide binding]; other site 266264010769 putative Zn2+ binding site [ion binding]; other site 266264010770 AsnC family; Region: AsnC_trans_reg; pfam01037 266264010771 Eps15 homology domain; Region: EH; smart00027 266264010772 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 266264010773 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 266264010774 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 266264010775 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 266264010776 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 266264010777 heme-binding site [chemical binding]; other site 266264010778 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 266264010779 FAD binding pocket [chemical binding]; other site 266264010780 FAD binding motif [chemical binding]; other site 266264010781 phosphate binding motif [ion binding]; other site 266264010782 beta-alpha-beta structure motif; other site 266264010783 NAD binding pocket [chemical binding]; other site 266264010784 Heme binding pocket [chemical binding]; other site 266264010785 Predicted transcriptional regulator [Transcription]; Region: COG1959 266264010786 Helix-turn-helix domains; Region: HTH; cl00088 266264010787 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 266264010788 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266264010789 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 266264010790 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 266264010791 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 266264010792 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 266264010793 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 266264010794 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 266264010795 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 266264010796 GspL periplasmic domain; Region: GspL_C; cl14909 266264010797 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 266264010798 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 266264010799 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 266264010800 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266264010801 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266264010802 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266264010803 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 266264010804 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264010805 type II secretion system protein E; Region: type_II_gspE; TIGR02533 266264010806 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266264010807 Walker A motif; other site 266264010808 ATP binding site [chemical binding]; other site 266264010809 Walker B motif; other site 266264010810 type II secretion system protein F; Region: GspF; TIGR02120 266264010811 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264010812 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264010813 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 266264010814 putative metal binding site [ion binding]; other site 266264010815 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 266264010816 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 266264010817 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 266264010818 dimer interface [polypeptide binding]; other site 266264010819 PYR/PP interface [polypeptide binding]; other site 266264010820 TPP binding site [chemical binding]; other site 266264010821 substrate binding site [chemical binding]; other site 266264010822 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 266264010823 TPP-binding site; other site 266264010824 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 266264010825 putative acetyltransferase; Provisional; Region: PRK03624 266264010826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264010827 Coenzyme A binding pocket [chemical binding]; other site 266264010828 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 266264010829 dimer interface [polypeptide binding]; other site 266264010830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264010831 metal binding site [ion binding]; metal-binding site 266264010832 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264010833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264010834 putative substrate translocation pore; other site 266264010835 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 266264010836 putative active site [active] 266264010837 metal binding site [ion binding]; metal-binding site 266264010838 metabolite-proton symporter; Region: 2A0106; TIGR00883 266264010839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264010840 putative substrate translocation pore; other site 266264010841 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 266264010842 LysE type translocator; Region: LysE; cl00565 266264010843 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266264010844 Cation efflux family; Region: Cation_efflux; cl00316 266264010845 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 266264010846 ligand binding site; other site 266264010847 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 266264010848 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 266264010849 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 266264010850 B12 binding site [chemical binding]; other site 266264010851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264010852 FeS/SAM binding site; other site 266264010853 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 266264010854 putative active site [active] 266264010855 YdjC motif; other site 266264010856 Mg binding site [ion binding]; other site 266264010857 putative homodimer interface [polypeptide binding]; other site 266264010858 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 266264010859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264010860 NMT1-like family; Region: NMT1_2; cl15260 266264010861 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 266264010862 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264010863 FAD binding site [chemical binding]; other site 266264010864 substrate binding site [chemical binding]; other site 266264010865 catalytic base [active] 266264010866 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264010867 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264010868 active site 266264010869 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264010870 enoyl-CoA hydratase; Validated; Region: PRK08139 266264010871 substrate binding site [chemical binding]; other site 266264010872 oxyanion hole (OAH) forming residues; other site 266264010873 trimer interface [polypeptide binding]; other site 266264010874 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264010875 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264010876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264010877 NMT1-like family; Region: NMT1_2; cl15260 266264010878 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 266264010879 Helix-turn-helix domains; Region: HTH; cl00088 266264010880 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266264010881 putative dimerization interface [polypeptide binding]; other site 266264010882 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 266264010883 active site 266264010884 metal binding site [ion binding]; metal-binding site 266264010885 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266264010886 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266264010887 catalytic residues [active] 266264010888 DsrE/DsrF-like family; Region: DrsE; cl00672 266264010889 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 266264010890 Predicted secreted protein [Function unknown]; Region: COG5501 266264010891 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 266264010892 Cytochrome c; Region: Cytochrom_C; cl11414 266264010893 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 266264010894 EamA-like transporter family; Region: EamA; cl01037 266264010895 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266264010896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264010897 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 266264010898 Cytochrome c; Region: Cytochrom_C; cl11414 266264010899 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 266264010900 BON domain; Region: BON; cl02771 266264010901 BON domain; Region: BON; cl02771 266264010902 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 266264010903 dimer interface [polypeptide binding]; other site 266264010904 active site 266264010905 Restriction endonuclease; Region: Mrr_cat; cl00516 266264010906 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 266264010907 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 266264010908 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266264010909 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 266264010910 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264010911 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 266264010912 active site 266264010913 catalytic site [active] 266264010914 substrate binding site [chemical binding]; other site 266264010915 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 266264010916 ArsC family; Region: ArsC; pfam03960 266264010917 catalytic residues [active] 266264010918 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 266264010919 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264010920 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264010921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264010922 Coenzyme A binding pocket [chemical binding]; other site 266264010923 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264010924 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266264010925 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264010926 Helix-turn-helix domains; Region: HTH; cl00088 266264010927 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 266264010928 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 266264010929 putative metal binding site [ion binding]; other site 266264010930 allantoate amidohydrolase; Reviewed; Region: PRK12890 266264010931 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266264010932 active site 266264010933 metal binding site [ion binding]; metal-binding site 266264010934 dimer interface [polypeptide binding]; other site 266264010935 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 266264010936 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266264010937 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264010938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264010939 DNA-binding site [nucleotide binding]; DNA binding site 266264010940 FCD domain; Region: FCD; cl11656 266264010941 Helix-turn-helix domains; Region: HTH; cl00088 266264010942 transcriptional activator TtdR; Provisional; Region: PRK09801 266264010943 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264010944 putative effector binding pocket; other site 266264010945 dimerization interface [polypeptide binding]; other site 266264010946 glyoxylate carboligase; Provisional; Region: PRK11269 266264010947 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264010948 PYR/PP interface [polypeptide binding]; other site 266264010949 dimer interface [polypeptide binding]; other site 266264010950 TPP binding site [chemical binding]; other site 266264010951 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266264010952 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266264010953 TPP-binding site [chemical binding]; other site 266264010954 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 266264010955 tartronate semialdehyde reductase; Provisional; Region: PRK15059 266264010956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264010957 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 266264010958 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 266264010959 MOFRL family; Region: MOFRL; pfam05161 266264010960 pyruvate kinase; Provisional; Region: PRK06247 266264010961 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266264010962 domain interfaces; other site 266264010963 active site 266264010964 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 266264010965 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 266264010966 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266264010967 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266264010968 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266264010969 DNA binding residues [nucleotide binding] 266264010970 dimer interface [polypeptide binding]; other site 266264010971 putative metal binding site [ion binding]; other site 266264010972 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 266264010973 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 266264010974 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 266264010975 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 266264010976 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 266264010977 Short C-terminal domain; Region: SHOCT; cl01373 266264010978 Predicted membrane protein [Function unknown]; Region: COG3766 266264010979 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 266264010980 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 266264010981 spermidine synthase; Provisional; Region: PRK03612 266264010982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264010983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264010984 S-adenosylmethionine binding site [chemical binding]; other site 266264010985 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266264010986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264010987 Peptidase family M48; Region: Peptidase_M48; cl12018 266264010988 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266264010989 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266264010990 conserved cys residue [active] 266264010991 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 266264010992 Cytochrome P450; Region: p450; pfam00067 266264010993 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 266264010994 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264010995 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 266264010996 FAD binding pocket [chemical binding]; other site 266264010997 FAD binding motif [chemical binding]; other site 266264010998 catalytic residues [active] 266264010999 NAD binding pocket [chemical binding]; other site 266264011000 phosphate binding motif [ion binding]; other site 266264011001 beta-alpha-beta structure motif; other site 266264011002 RF-1 domain; Region: RF-1; cl02875 266264011003 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264011004 FAD binding domain; Region: FAD_binding_4; pfam01565 266264011005 Berberine and berberine like; Region: BBE; pfam08031 266264011006 enoyl-CoA hydratase; Validated; Region: PRK08139 266264011007 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264011008 substrate binding site [chemical binding]; other site 266264011009 oxyanion hole (OAH) forming residues; other site 266264011010 trimer interface [polypeptide binding]; other site 266264011011 Cytochrome c; Region: Cytochrom_C; cl11414 266264011012 Cytochrome c; Region: Cytochrom_C; cl11414 266264011013 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 266264011014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264011015 FeS/SAM binding site; other site 266264011016 HemN C-terminal domain; Region: HemN_C; pfam06969 266264011017 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264011018 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 266264011019 putative ligand binding site [chemical binding]; other site 266264011020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264011021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264011022 dimer interface [polypeptide binding]; other site 266264011023 phosphorylation site [posttranslational modification] 266264011024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264011025 ATP binding site [chemical binding]; other site 266264011026 Mg2+ binding site [ion binding]; other site 266264011027 G-X-G motif; other site 266264011028 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266264011029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011030 active site 266264011031 phosphorylation site [posttranslational modification] 266264011032 intermolecular recognition site; other site 266264011033 dimerization interface [polypeptide binding]; other site 266264011034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264011035 DNA binding site [nucleotide binding] 266264011036 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 266264011037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264011038 Family description; Region: UvrD_C_2; cl15862 266264011041 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 266264011042 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266264011043 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 266264011044 lipoyl attachment site [posttranslational modification]; other site 266264011045 glycine dehydrogenase; Provisional; Region: PRK05367 266264011046 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266264011047 tetramer interface [polypeptide binding]; other site 266264011048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264011049 catalytic residue [active] 266264011050 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266264011051 tetramer interface [polypeptide binding]; other site 266264011052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264011053 catalytic residue [active] 266264011054 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 266264011055 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 266264011056 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 266264011057 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264011058 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 266264011059 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 266264011060 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266264011061 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266264011062 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 266264011063 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264011064 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266264011065 dimerization interface [polypeptide binding]; other site 266264011066 ligand binding site [chemical binding]; other site 266264011067 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 266264011068 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 266264011069 Proline dehydrogenase; Region: Pro_dh; cl03282 266264011070 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 266264011071 Glutamate binding site [chemical binding]; other site 266264011072 NAD binding site [chemical binding]; other site 266264011073 catalytic residues [active] 266264011074 primosome assembly protein PriA; Validated; Region: PRK05580 266264011075 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264011076 ATP binding site [chemical binding]; other site 266264011077 putative Mg++ binding site [ion binding]; other site 266264011078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264011079 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 266264011080 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 266264011081 substrate binding site [chemical binding]; other site 266264011082 active site 266264011083 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264011084 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266264011085 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 266264011086 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 266264011087 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 266264011088 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 266264011089 alpha subunit interaction interface [polypeptide binding]; other site 266264011090 Walker A motif; other site 266264011091 ATP binding site [chemical binding]; other site 266264011092 Walker B motif; other site 266264011093 inhibitor binding site; inhibition site 266264011094 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266264011095 ATP synthase; Region: ATP-synt; cl00365 266264011096 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 266264011097 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 266264011098 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 266264011099 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 266264011100 beta subunit interaction interface [polypeptide binding]; other site 266264011101 Walker A motif; other site 266264011102 ATP binding site [chemical binding]; other site 266264011103 Walker B motif; other site 266264011104 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266264011105 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 266264011106 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 266264011107 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 266264011108 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 266264011109 ATP synthase subunit C; Region: ATP-synt_C; cl00466 266264011110 ATP synthase A chain; Region: ATP-synt_A; cl00413 266264011111 ATP synthase I chain; Region: ATP_synt_I; cl09170 266264011112 ParB-like partition proteins; Region: parB_part; TIGR00180 266264011113 ParB-like nuclease domain; Region: ParBc; cl02129 266264011114 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266264011115 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264011116 P-loop; other site 266264011117 Magnesium ion binding site [ion binding]; other site 266264011118 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264011119 Magnesium ion binding site [ion binding]; other site 266264011120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264011121 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 266264011122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011123 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 266264011124 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266264011125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264011126 NMT1-like family; Region: NMT1_2; cl15260 266264011127 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264011128 Helix-turn-helix domains; Region: HTH; cl00088 266264011129 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264011130 dimerization interface [polypeptide binding]; other site 266264011131 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264011132 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264011133 Walker A/P-loop; other site 266264011134 ATP binding site [chemical binding]; other site 266264011135 Q-loop/lid; other site 266264011136 ABC transporter signature motif; other site 266264011137 Walker B; other site 266264011138 D-loop; other site 266264011139 H-loop/switch region; other site 266264011140 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264011141 TM-ABC transporter signature motif; other site 266264011142 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264011143 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264011144 Walker A/P-loop; other site 266264011145 ATP binding site [chemical binding]; other site 266264011146 Q-loop/lid; other site 266264011147 ABC transporter signature motif; other site 266264011148 Walker B; other site 266264011149 D-loop; other site 266264011150 H-loop/switch region; other site 266264011151 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264011152 TM-ABC transporter signature motif; other site 266264011153 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264011154 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 266264011155 putative ligand binding site [chemical binding]; other site 266264011156 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 266264011157 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264011158 TM-ABC transporter signature motif; other site 266264011159 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264011160 TM-ABC transporter signature motif; other site 266264011161 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264011162 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 266264011163 putative ligand binding site [chemical binding]; other site 266264011164 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264011165 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264011166 Walker A/P-loop; other site 266264011167 ATP binding site [chemical binding]; other site 266264011168 Q-loop/lid; other site 266264011169 ABC transporter signature motif; other site 266264011170 Walker B; other site 266264011171 D-loop; other site 266264011172 H-loop/switch region; other site 266264011173 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264011174 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264011175 Walker A/P-loop; other site 266264011176 ATP binding site [chemical binding]; other site 266264011177 Q-loop/lid; other site 266264011178 ABC transporter signature motif; other site 266264011179 Walker B; other site 266264011180 D-loop; other site 266264011181 H-loop/switch region; other site 266264011182 choline dehydrogenase; Validated; Region: PRK02106 266264011183 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264011184 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266264011185 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264011186 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266264011187 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 266264011188 DNA binding residues [nucleotide binding] 266264011189 dimer interface [polypeptide binding]; other site 266264011190 copper binding site [ion binding]; other site 266264011191 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264011192 metal-binding site [ion binding] 266264011193 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264011194 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264011195 metal-binding site [ion binding] 266264011196 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264011197 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264011198 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264011199 metal-binding site [ion binding] 266264011200 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 266264011201 ornithine cyclodeaminase; Validated; Region: PRK07340 266264011202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011203 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266264011204 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264011205 active site 266264011206 catalytic tetrad [active] 266264011207 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 266264011208 Transglycosylase; Region: Transgly; cl07896 266264011209 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264011210 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 266264011211 YhhN-like protein; Region: YhhN; cl01505 266264011212 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 266264011213 MG2 domain; Region: A2M_N; pfam01835 266264011214 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 266264011215 Alpha-2-macroglobulin family; Region: A2M; pfam00207 266264011216 Helix-turn-helix domains; Region: HTH; cl00088 266264011217 AsnC family; Region: AsnC_trans_reg; pfam01037 266264011218 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 266264011219 cofactor binding site; other site 266264011220 metal binding site [ion binding]; metal-binding site 266264011221 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 266264011222 aromatic arch; other site 266264011223 DCoH dimer interaction site [polypeptide binding]; other site 266264011224 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 266264011225 DCoH tetramer interaction site [polypeptide binding]; other site 266264011226 substrate binding site [chemical binding]; other site 266264011227 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266264011228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011229 active site 266264011230 phosphorylation site [posttranslational modification] 266264011231 intermolecular recognition site; other site 266264011232 dimerization interface [polypeptide binding]; other site 266264011233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264011234 DNA binding site [nucleotide binding] 266264011235 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266264011236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264011237 dimer interface [polypeptide binding]; other site 266264011238 phosphorylation site [posttranslational modification] 266264011239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264011240 ATP binding site [chemical binding]; other site 266264011241 Mg2+ binding site [ion binding]; other site 266264011242 G-X-G motif; other site 266264011243 SET domain; Region: SET; cl02566 266264011244 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266264011245 IHF dimer interface [polypeptide binding]; other site 266264011246 IHF - DNA interface [nucleotide binding]; other site 266264011247 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 266264011248 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 266264011249 amphipathic channel; other site 266264011250 Asn-Pro-Ala signature motifs; other site 266264011251 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 266264011252 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 266264011253 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266264011254 Predicted permeases [General function prediction only]; Region: RarD; COG2962 266264011255 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266264011256 active site 266264011257 DNA polymerase IV; Validated; Region: PRK02406 266264011258 DNA binding site [nucleotide binding] 266264011259 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266264011260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264011261 putative substrate translocation pore; other site 266264011262 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 266264011263 Cache domain; Region: Cache_1; pfam02743 266264011264 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264011265 metal binding site [ion binding]; metal-binding site 266264011266 active site 266264011267 I-site; other site 266264011268 NMT1-like family; Region: NMT1_2; cl15260 266264011269 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266264011270 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266264011271 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264011272 CoenzymeA binding site [chemical binding]; other site 266264011273 subunit interaction site [polypeptide binding]; other site 266264011274 PHB binding site; other site 266264011275 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 266264011276 active site 266264011277 nucleophile elbow; other site 266264011278 glutathione reductase; Validated; Region: PRK06116 266264011279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264011280 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264011281 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 266264011282 Helix-turn-helix domains; Region: HTH; cl00088 266264011283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264011284 dimerization interface [polypeptide binding]; other site 266264011285 amidase; Provisional; Region: PRK07487 266264011286 Amidase; Region: Amidase; cl11426 266264011287 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 266264011288 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 266264011289 Na binding site [ion binding]; other site 266264011290 Response regulator receiver domain; Region: Response_reg; pfam00072 266264011291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011292 active site 266264011293 phosphorylation site [posttranslational modification] 266264011294 intermolecular recognition site; other site 266264011295 dimerization interface [polypeptide binding]; other site 266264011296 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264011297 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 266264011298 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 266264011299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264011300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264011301 dimer interface [polypeptide binding]; other site 266264011302 phosphorylation site [posttranslational modification] 266264011303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264011304 ATP binding site [chemical binding]; other site 266264011305 Mg2+ binding site [ion binding]; other site 266264011306 G-X-G motif; other site 266264011307 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 266264011308 16S rRNA methyltransferase B; Provisional; Region: PRK10901 266264011309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264011310 S-adenosylmethionine binding site [chemical binding]; other site 266264011311 Peptidase family M48; Region: Peptidase_M48; cl12018 266264011312 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 266264011313 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 266264011314 putative active site [active] 266264011315 substrate binding site [chemical binding]; other site 266264011316 putative cosubstrate binding site; other site 266264011317 catalytic site [active] 266264011318 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 266264011319 substrate binding site [chemical binding]; other site 266264011320 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266264011321 active site 266264011322 catalytic residues [active] 266264011323 metal binding site [ion binding]; metal-binding site 266264011324 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264011325 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 266264011326 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 266264011327 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266264011328 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266264011329 catalytic residues [active] 266264011330 DNA topoisomerase III; Validated; Region: PRK08173 266264011331 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 266264011332 active site 266264011333 putative interdomain interaction site [polypeptide binding]; other site 266264011334 putative metal-binding site [ion binding]; other site 266264011335 putative nucleotide binding site [chemical binding]; other site 266264011336 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266264011337 domain I; other site 266264011338 DNA binding groove [nucleotide binding] 266264011339 phosphate binding site [ion binding]; other site 266264011340 domain II; other site 266264011341 domain III; other site 266264011342 nucleotide binding site [chemical binding]; other site 266264011343 catalytic site [active] 266264011344 domain IV; other site 266264011345 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 266264011346 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 266264011347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264011348 Helix-turn-helix domains; Region: HTH; cl00088 266264011349 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264011350 putative effector binding pocket; other site 266264011351 dimerization interface [polypeptide binding]; other site 266264011352 Protein of unknown function (DUF466); Region: DUF466; cl01082 266264011353 carbon starvation protein A; Provisional; Region: PRK15015 266264011354 Carbon starvation protein CstA; Region: CstA; pfam02554 266264011355 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 266264011356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 266264011357 Cache domain; Region: Cache_2; cl07034 266264011358 Histidine kinase; Region: HisKA_3; pfam07730 266264011359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264011360 ATP binding site [chemical binding]; other site 266264011361 Mg2+ binding site [ion binding]; other site 266264011362 G-X-G motif; other site 266264011363 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264011364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011365 active site 266264011366 phosphorylation site [posttranslational modification] 266264011367 intermolecular recognition site; other site 266264011368 dimerization interface [polypeptide binding]; other site 266264011369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264011370 DNA binding residues [nucleotide binding] 266264011371 dimerization interface [polypeptide binding]; other site 266264011372 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 266264011373 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 266264011374 active site 266264011375 substrate-binding site [chemical binding]; other site 266264011376 metal-binding site [ion binding] 266264011377 GTP binding site [chemical binding]; other site 266264011378 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266264011379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011380 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 266264011381 MOSC domain; Region: MOSC; pfam03473 266264011382 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264011383 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264011384 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264011385 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 266264011386 Protein export membrane protein; Region: SecD_SecF; cl14618 266264011387 Protein of unknown function, DUF399; Region: DUF399; cl01139 266264011388 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266264011389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266264011390 dimer interface [polypeptide binding]; other site 266264011391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264011392 ATP binding site [chemical binding]; other site 266264011393 Mg2+ binding site [ion binding]; other site 266264011394 G-X-G motif; other site 266264011395 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266264011396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011397 active site 266264011398 phosphorylation site [posttranslational modification] 266264011399 intermolecular recognition site; other site 266264011400 dimerization interface [polypeptide binding]; other site 266264011401 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264011402 DNA binding site [nucleotide binding] 266264011403 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266264011404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264011405 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 266264011406 Helix-turn-helix domains; Region: HTH; cl00088 266264011407 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 266264011408 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264011409 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264011410 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264011411 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266264011412 Protein export membrane protein; Region: SecD_SecF; cl14618 266264011413 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 266264011414 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 266264011415 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 266264011416 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 266264011417 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 266264011418 Helix-turn-helix domains; Region: HTH; cl00088 266264011419 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 266264011420 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264011421 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266264011422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011424 short chain dehydrogenase; Provisional; Region: PRK05650 266264011425 NAD(P) binding site [chemical binding]; other site 266264011426 active site 266264011427 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264011428 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 266264011429 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 266264011430 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 266264011431 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266264011432 DNA binding residues [nucleotide binding] 266264011433 putative dimer interface [polypeptide binding]; other site 266264011434 Helix-turn-helix domains; Region: HTH; cl00088 266264011435 cell density-dependent motility repressor; Provisional; Region: PRK10082 266264011436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264011437 dimerization interface [polypeptide binding]; other site 266264011438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264011439 NMT1-like family; Region: NMT1_2; cl15260 266264011440 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 266264011441 putative active site [active] 266264011442 Zn binding site [ion binding]; other site 266264011443 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 266264011444 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264011445 Helix-turn-helix domains; Region: HTH; cl00088 266264011446 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 266264011447 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 266264011448 trmE is a tRNA modification GTPase; Region: trmE; cd04164 266264011449 G1 box; other site 266264011450 GTP/Mg2+ binding site [chemical binding]; other site 266264011451 Switch I region; other site 266264011452 G2 box; other site 266264011453 Switch II region; other site 266264011454 G3 box; other site 266264011455 G4 box; other site 266264011456 G5 box; other site 266264011457 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 266264011458 CHAD domain; Region: CHAD; cl10506 266264011459 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 266264011460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264011461 S-adenosylmethionine binding site [chemical binding]; other site 266264011462 membrane protein insertase; Provisional; Region: PRK01318 266264011463 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 266264011464 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 266264011465 Haemolytic domain; Region: Haemolytic; cl00506 266264011466 Ribonuclease P; Region: Ribonuclease_P; cl00457 266264011467 hypothetical protein 266264011468 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 266264011469 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266264011470 DNA-binding site [nucleotide binding]; DNA binding site 266264011471 RNA-binding motif; other site 266264011472 ParA-like protein; Provisional; Region: PHA02518 266264011473 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264011474 P-loop; other site 266264011475 Magnesium ion binding site [ion binding]; other site 266264011476 ParB-like partition proteins; Region: parB_part; TIGR00180 266264011477 ParB-like nuclease domain; Region: ParBc; cl02129 266264011478 Phage integrase protein; Region: DUF3701; pfam12482 266264011479 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264011480 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264011481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264011482 DNA binding residues [nucleotide binding] 266264011483 dimerization interface [polypeptide binding]; other site 266264011484 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264011485 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264011486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264011487 NMT1-like family; Region: NMT1_2; cl15260 266264011488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264011489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011490 NAD(P) binding site [chemical binding]; other site 266264011491 active site 266264011492 lipid-transfer protein; Provisional; Region: PRK08256 266264011493 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264011494 active site 266264011495 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264011496 AMP-binding enzyme; Region: AMP-binding; cl15778 266264011497 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264011498 Isochorismatase family; Region: Isochorismatase; pfam00857 266264011499 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264011500 catalytic triad [active] 266264011501 dimer interface [polypeptide binding]; other site 266264011502 conserved cis-peptide bond; other site 266264011503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264011504 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 266264011505 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266264011506 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264011507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264011508 DNA binding residues [nucleotide binding] 266264011509 dimerization interface [polypeptide binding]; other site 266264011510 aminopeptidase P (fragment) 266264011511 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266264011512 active site 266264011513 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266264011514 Bacterial sugar transferase; Region: Bac_transf; cl00939 266264011515 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266264011516 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264011517 active site 266264011518 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 266264011519 dimer interface [polypeptide binding]; other site 266264011520 motif 1; other site 266264011521 active site 266264011522 motif 2; other site 266264011523 motif 3; other site 266264011524 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 266264011525 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 266264011526 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264011527 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264011528 ligand binding site [chemical binding]; other site 266264011529 flexible hinge region; other site 266264011530 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264011531 non-specific DNA interactions [nucleotide binding]; other site 266264011532 DNA binding site [nucleotide binding] 266264011533 sequence specific DNA binding site [nucleotide binding]; other site 266264011534 putative cAMP binding site [chemical binding]; other site 266264011535 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 266264011536 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 266264011537 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266264011538 Substrate binding site; other site 266264011539 Cupin domain; Region: Cupin_2; cl09118 266264011540 tyrosine kinase; Provisional; Region: PRK11519 266264011541 Chain length determinant protein; Region: Wzz; cl15801 266264011542 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264011543 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 266264011544 Nucleotide binding site [chemical binding]; other site 266264011545 P loop; other site 266264011546 DTAP/Switch II; other site 266264011547 Switch I; other site 266264011548 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 266264011549 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 266264011550 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 266264011551 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266264011552 short chain dehydrogenase; Provisional; Region: PRK05650 266264011553 NADP binding site [chemical binding]; other site 266264011554 active site 266264011555 steroid binding site; other site 266264011556 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 266264011557 tyrosine kinase; Provisional; Region: PRK11519 266264011558 Chain length determinant protein; Region: Wzz; cl15801 266264011559 Chain length determinant protein; Region: Wzz; cl15801 266264011560 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264011561 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266264011562 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266264011563 active site 266264011564 polysaccharide export protein Wza; Provisional; Region: PRK15078 266264011565 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266264011566 SLBB domain; Region: SLBB; pfam10531 266264011567 YdjC-family proteins; Region: YdjC_like; cd10788 266264011568 putative active site [active] 266264011569 YdjC motif; other site 266264011570 Mg binding site [ion binding]; other site 266264011571 putative homodimer interface [polypeptide binding]; other site 266264011572 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266264011573 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264011574 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266264011575 putative acyl transferase; Provisional; Region: PRK10502 266264011576 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 266264011577 putative trimer interface [polypeptide binding]; other site 266264011578 putative active site [active] 266264011579 putative substrate binding site [chemical binding]; other site 266264011580 putative CoA binding site [chemical binding]; other site 266264011581 putative glycosyl transferase; Provisional; Region: PRK10307 266264011582 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 266264011583 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 266264011584 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 266264011585 NADP binding site [chemical binding]; other site 266264011586 active site 266264011587 putative substrate binding site [chemical binding]; other site 266264011588 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266264011589 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 266264011590 NADP-binding site; other site 266264011591 homotetramer interface [polypeptide binding]; other site 266264011592 substrate binding site [chemical binding]; other site 266264011593 homodimer interface [polypeptide binding]; other site 266264011594 active site 266264011595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 266264011596 active site 266264011597 intermolecular recognition site; other site 266264011598 dimerization interface [polypeptide binding]; other site 266264011599 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264011600 DNA binding residues [nucleotide binding] 266264011601 dimerization interface [polypeptide binding]; other site 266264011602 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 266264011603 oligomer interface [polypeptide binding]; other site 266264011604 active site 266264011605 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264011606 active site 266264011607 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266264011608 substrate binding site [chemical binding]; other site 266264011609 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266264011610 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266264011611 substrate binding site [chemical binding]; other site 266264011612 ligand binding site [chemical binding]; other site 266264011613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264011614 NMT1-like family; Region: NMT1_2; cl15260 266264011615 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266264011616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264011617 DNA-binding site [nucleotide binding]; DNA binding site 266264011618 UTRA domain; Region: UTRA; cl01230 266264011619 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39G; cd02423 266264011620 putative active site [active] 266264011621 IncA protein; Region: IncA; pfam04156 266264011622 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264011623 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 266264011624 putative ligand binding site [chemical binding]; other site 266264011625 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 266264011626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011627 NAD(P) binding site [chemical binding]; other site 266264011628 active site 266264011629 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 266264011630 Helix-turn-helix domains; Region: HTH; cl00088 266264011631 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266264011632 putative dimerization interface [polypeptide binding]; other site 266264011633 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 266264011634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264011635 NMT1-like family; Region: NMT1_2; cl15260 266264011636 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266264011637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264011639 hypothetical protein; Provisional; Region: PRK01346 266264011640 Coenzyme A binding pocket [chemical binding]; other site 266264011641 AMP nucleosidase; Provisional; Region: PRK08292 266264011642 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 266264011643 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 266264011644 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 266264011645 2-isopropylmalate synthase; Validated; Region: PRK03739 266264011646 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 266264011647 active site 266264011648 catalytic residues [active] 266264011649 metal binding site [ion binding]; metal-binding site 266264011650 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 266264011651 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 266264011652 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 266264011653 G1 box; other site 266264011654 GTP/Mg2+ binding site [chemical binding]; other site 266264011655 Switch I region; other site 266264011656 G2 box; other site 266264011657 G3 box; other site 266264011658 Switch II region; other site 266264011659 G4 box; other site 266264011660 G5 box; other site 266264011661 Nucleoside recognition; Region: Gate; cl00486 266264011662 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 266264011663 Nucleoside recognition; Region: Gate; cl00486 266264011664 FeoA domain; Region: FeoA; cl00838 266264011665 Helix-turn-helix domains; Region: HTH; cl00088 266264011666 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266264011667 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 266264011668 putative dimerization interface [polypeptide binding]; other site 266264011669 putative substrate binding pocket [chemical binding]; other site 266264011670 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264011671 active site 266264011672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264011673 NMT1-like family; Region: NMT1_2; cl15260 266264011674 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264011675 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264011676 glycolate transporter; Provisional; Region: PRK09695 266264011677 L-lactate permease; Region: Lactate_perm; cl00701 266264011678 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 266264011679 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 266264011680 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 266264011681 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 266264011682 Cysteine-rich domain; Region: CCG; pfam02754 266264011683 Cysteine-rich domain; Region: CCG; pfam02754 266264011684 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264011685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264011686 DNA-binding site [nucleotide binding]; DNA binding site 266264011687 FCD domain; Region: FCD; cl11656 266264011688 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266264011689 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 266264011690 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 266264011691 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 266264011692 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 266264011693 putative deacylase active site [active] 266264011694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264011695 Helix-turn-helix domains; Region: HTH; cl00088 266264011696 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264011697 putative effector binding pocket; other site 266264011698 dimerization interface [polypeptide binding]; other site 266264011699 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 266264011700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264011701 putative substrate translocation pore; other site 266264011702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264011703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264011704 active site 266264011705 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266264011706 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266264011707 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266264011708 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266264011709 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266264011710 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 266264011711 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 266264011712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264011713 AlkA N-terminal domain; Region: AlkA_N; cl05528 266264011714 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 266264011715 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266264011716 minor groove reading motif; other site 266264011717 helix-hairpin-helix signature motif; other site 266264011718 substrate binding pocket [chemical binding]; other site 266264011719 active site 266264011720 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266264011721 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266264011722 DNA binding site [nucleotide binding] 266264011723 active site 266264011724 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 266264011725 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266264011726 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266264011727 LysE type translocator; Region: LysE; cl00565 266264011728 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264011729 Helix-turn-helix domains; Region: HTH; cl00088 266264011730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264011731 dimerization interface [polypeptide binding]; other site 266264011732 Flagellar regulator YcgR; Region: YcgR; pfam07317 266264011733 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 266264011734 PilZ domain; Region: PilZ; cl01260 266264011735 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266264011736 Helix-turn-helix domains; Region: HTH; cl00088 266264011737 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264011738 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264011739 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 266264011740 active site 266264011741 nucleophile elbow; other site 266264011742 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 266264011743 Surface antigen; Region: Bac_surface_Ag; cl03097 266264011744 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 266264011745 NAD-dependent deacetylase; Provisional; Region: PRK05333 266264011746 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 266264011747 NAD+ binding site [chemical binding]; other site 266264011748 substrate binding site [chemical binding]; other site 266264011749 Zn binding site [ion binding]; other site 266264011750 SlyX; Region: SlyX; cl01090 266264011751 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264011752 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266264011753 dimer interface [polypeptide binding]; other site 266264011754 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 266264011755 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266264011756 Ligand Binding Site [chemical binding]; other site 266264011757 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266264011758 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264011759 active site 266264011760 catalytic tetrad [active] 266264011761 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 266264011762 Transglycosylase; Region: Transgly; cl07896 266264011763 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264011764 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 266264011765 elongation factor G; Reviewed; Region: PRK00007 266264011766 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 266264011767 G1 box; other site 266264011768 putative GEF interaction site [polypeptide binding]; other site 266264011769 GTP/Mg2+ binding site [chemical binding]; other site 266264011770 Switch I region; other site 266264011771 G2 box; other site 266264011772 G3 box; other site 266264011773 Switch II region; other site 266264011774 G4 box; other site 266264011775 G5 box; other site 266264011776 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266264011777 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266264011778 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266264011779 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 266264011780 NodB motif; other site 266264011781 active site 266264011782 catalytic site [active] 266264011783 metal binding site [ion binding]; metal-binding site 266264011784 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 266264011785 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 266264011786 Cache domain; Region: Cache_2; cl07034 266264011787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264011788 dimer interface [polypeptide binding]; other site 266264011789 putative CheW interface [polypeptide binding]; other site 266264011790 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266264011791 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266264011792 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 266264011793 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266264011794 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 266264011795 active site residue [active] 266264011796 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 266264011797 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264011798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011799 active site 266264011800 phosphorylation site [posttranslational modification] 266264011801 intermolecular recognition site; other site 266264011802 dimerization interface [polypeptide binding]; other site 266264011803 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264011804 DNA binding residues [nucleotide binding] 266264011805 dimerization interface [polypeptide binding]; other site 266264011806 OsmC-like protein; Region: OsmC; cl00767 266264011807 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 266264011808 GIY-YIG motif/motif A; other site 266264011809 putative active site [active] 266264011810 putative metal binding site [ion binding]; other site 266264011811 OsmC-like protein; Region: OsmC; cl00767 266264011812 Helix-turn-helix domains; Region: HTH; cl00088 266264011813 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266264011814 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266264011815 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266264011816 protein binding site [polypeptide binding]; other site 266264011817 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266264011818 protein binding site [polypeptide binding]; other site 266264011819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264011820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264011821 putative substrate translocation pore; other site 266264011822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264011823 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264011824 Helix-turn-helix domains; Region: HTH; cl00088 266264011825 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 266264011826 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266264011827 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 266264011828 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266264011829 MoxR-like ATPases [General function prediction only]; Region: COG0714 266264011830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264011831 Walker A motif; other site 266264011832 ATP binding site [chemical binding]; other site 266264011833 Walker B motif; other site 266264011834 arginine finger; other site 266264011835 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264011836 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264011837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264011838 DNA-binding site [nucleotide binding]; DNA binding site 266264011839 FCD domain; Region: FCD; cl11656 266264011840 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266264011841 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264011842 catalytic loop [active] 266264011843 iron binding site [ion binding]; other site 266264011844 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 266264011845 FAD binding pocket [chemical binding]; other site 266264011846 FAD binding motif [chemical binding]; other site 266264011847 phosphate binding motif [ion binding]; other site 266264011848 beta-alpha-beta structure motif; other site 266264011849 NAD binding pocket [chemical binding]; other site 266264011850 Domain of unknown function (DUF336); Region: DUF336; cl01249 266264011851 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 266264011852 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264011853 NAD(P) binding site [chemical binding]; other site 266264011854 catalytic residues [active] 266264011855 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 266264011856 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266264011857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011858 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264011859 catalytic loop [active] 266264011860 iron binding site [ion binding]; other site 266264011861 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264011862 catalytic loop [active] 266264011863 iron binding site [ion binding]; other site 266264011864 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266264011865 Helix-turn-helix domains; Region: HTH; cl00088 266264011866 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264011867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264011868 Helix-turn-helix domains; Region: HTH; cl00088 266264011869 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264011870 putative effector binding pocket; other site 266264011871 dimerization interface [polypeptide binding]; other site 266264011872 YGGT family; Region: YGGT; cl00508 266264011873 YGGT family; Region: YGGT; cl00508 266264011874 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264011875 Helix-turn-helix domains; Region: HTH; cl00088 266264011876 Dienelactone hydrolase family; Region: DLH; pfam01738 266264011877 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264011878 Dodecin; Region: Dodecin; cl01328 266264011879 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 266264011880 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266264011881 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266264011882 TadE-like protein; Region: TadE; cl10688 266264011883 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 266264011884 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266264011885 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266264011886 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264011887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011888 active site 266264011889 phosphorylation site [posttranslational modification] 266264011890 intermolecular recognition site; other site 266264011891 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 266264011892 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266264011893 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266264011894 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266264011895 ATP binding site [chemical binding]; other site 266264011896 Walker A motif; other site 266264011897 hexamer interface [polypeptide binding]; other site 266264011898 Walker B motif; other site 266264011899 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264011900 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264011901 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 266264011902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264011903 binding surface 266264011904 TPR motif; other site 266264011905 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 266264011906 Predicted membrane protein [Function unknown]; Region: COG4655 266264011907 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 266264011908 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 266264011909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264011910 Walker A motif; other site 266264011911 ATP binding site [chemical binding]; other site 266264011912 Walker B motif; other site 266264011913 arginine finger; other site 266264011914 Helix-turn-helix domains; Region: HTH; cl00088 266264011915 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 266264011916 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 266264011917 active site 266264011918 metal binding site [ion binding]; metal-binding site 266264011919 DNA binding site [nucleotide binding] 266264011920 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 266264011921 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 266264011922 AAA domain; Region: AAA_23; pfam13476 266264011923 Walker A/P-loop; other site 266264011924 ATP binding site [chemical binding]; other site 266264011925 Q-loop/lid; other site 266264011926 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 266264011927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264011928 ABC transporter signature motif; other site 266264011929 Walker B; other site 266264011930 D-loop; other site 266264011931 H-loop/switch region; other site 266264011932 hypothetical protein; Provisional; Region: PRK09133 266264011933 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 266264011934 putative metal binding site [ion binding]; other site 266264011935 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264011936 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264011937 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 266264011938 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264011939 dimer interface [polypeptide binding]; other site 266264011940 active site 266264011941 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264011942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011943 NAD(P) binding site [chemical binding]; other site 266264011944 active site 266264011945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264011946 NMT1-like family; Region: NMT1_2; cl15260 266264011947 Helix-turn-helix domains; Region: HTH; cl00088 266264011948 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 266264011949 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264011950 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264011951 FMN binding site [chemical binding]; other site 266264011952 substrate binding site [chemical binding]; other site 266264011953 putative catalytic residue [active] 266264011954 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264011955 Int/Topo IB signature motif; other site 266264011956 DNA binding site [nucleotide binding] 266264011957 active site 266264011958 UDP-glucose 4-epimerase; Region: PLN02240 266264011959 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 266264011960 NAD binding site [chemical binding]; other site 266264011961 homodimer interface [polypeptide binding]; other site 266264011962 active site 266264011963 substrate binding site [chemical binding]; other site 266264011964 H-NS histone family; Region: Histone_HNS; pfam00816 266264011965 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 266264011966 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 266264011967 dimer interface [polypeptide binding]; other site 266264011968 ligand binding site [chemical binding]; other site 266264011969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264011970 dimerization interface [polypeptide binding]; other site 266264011971 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264011972 dimer interface [polypeptide binding]; other site 266264011973 putative CheW interface [polypeptide binding]; other site 266264011974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264011975 metal binding site [ion binding]; metal-binding site 266264011976 active site 266264011977 I-site; other site 266264011978 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264011979 Response regulator receiver domain; Region: Response_reg; pfam00072 266264011980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011981 active site 266264011982 phosphorylation site [posttranslational modification] 266264011983 intermolecular recognition site; other site 266264011984 dimerization interface [polypeptide binding]; other site 266264011985 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 266264011986 putative CheA interaction surface; other site 266264011987 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264011988 PAS fold; Region: PAS_3; pfam08447 266264011989 putative active site [active] 266264011990 heme pocket [chemical binding]; other site 266264011991 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264011992 dimerization interface [polypeptide binding]; other site 266264011993 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264011994 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264011995 dimer interface [polypeptide binding]; other site 266264011996 putative CheW interface [polypeptide binding]; other site 266264011997 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264011998 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264011999 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264012000 dimer interface [polypeptide binding]; other site 266264012001 putative CheW interface [polypeptide binding]; other site 266264012002 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 266264012003 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 266264012004 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 266264012005 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 266264012006 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266264012007 flagellar motor protein MotB; Validated; Region: motB; PRK09041 266264012008 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 266264012009 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264012010 ligand binding site [chemical binding]; other site 266264012011 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264012012 putative binding surface; other site 266264012013 active site 266264012014 CheY binding; Region: CheY-binding; pfam09078 266264012015 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 266264012016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264012017 ATP binding site [chemical binding]; other site 266264012018 Mg2+ binding site [ion binding]; other site 266264012019 G-X-G motif; other site 266264012020 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 266264012021 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 266264012022 putative CheA interaction surface; other site 266264012023 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 266264012024 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 266264012025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264012026 CheD chemotactic sensory transduction; Region: CheD; cl00810 266264012027 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 266264012028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012029 active site 266264012030 phosphorylation site [posttranslational modification] 266264012031 intermolecular recognition site; other site 266264012032 dimerization interface [polypeptide binding]; other site 266264012033 CheB methylesterase; Region: CheB_methylest; pfam01339 266264012034 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 266264012035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012036 active site 266264012037 phosphorylation site [posttranslational modification] 266264012038 intermolecular recognition site; other site 266264012039 dimerization interface [polypeptide binding]; other site 266264012040 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 266264012041 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 266264012042 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 266264012043 putative metal binding site [ion binding]; other site 266264012044 hypothetical protein; Provisional; Region: PRK11239 266264012045 Protein of unknown function, DUF480; Region: DUF480; cl01209 266264012046 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 266264012047 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 266264012048 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 266264012049 FHIPEP family; Region: FHIPEP; pfam00771 266264012050 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 266264012051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264012052 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 266264012053 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264012054 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 266264012055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264012056 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266264012057 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264012058 DNA binding residues [nucleotide binding] 266264012059 Flagellar protein FlhE; Region: FlhE; pfam06366 266264012060 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264012061 trimer interface [polypeptide binding]; other site 266264012062 eyelet of channel; other site 266264012063 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264012064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 266264012065 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 266264012066 Helix-turn-helix domains; Region: HTH; cl00088 266264012067 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266264012068 Helix-turn-helix domains; Region: HTH; cl00088 266264012069 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 266264012070 putative dimerization interface [polypeptide binding]; other site 266264012071 benzoate transport; Region: 2A0115; TIGR00895 266264012072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012073 putative substrate translocation pore; other site 266264012074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012075 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 266264012076 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 266264012077 putative active site [active] 266264012078 Fe(II) binding site [ion binding]; other site 266264012079 putative dimer interface [polypeptide binding]; other site 266264012080 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 266264012081 putative dimer interface [polypeptide binding]; other site 266264012082 putative N- and C-terminal domain interface [polypeptide binding]; other site 266264012083 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266264012084 Rubredoxin; Region: Rubredoxin; pfam00301 266264012085 iron binding site [ion binding]; other site 266264012086 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266264012087 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264012088 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264012089 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 266264012090 Helix-turn-helix domains; Region: HTH; cl00088 266264012091 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 266264012092 substrate binding pocket [chemical binding]; other site 266264012093 dimerization interface [polypeptide binding]; other site 266264012094 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 266264012095 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264012096 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 266264012097 dimer interface [polypeptide binding]; other site 266264012098 FMN binding site [chemical binding]; other site 266264012099 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 266264012100 dimer interface [polypeptide binding]; other site 266264012101 putative metal binding site [ion binding]; other site 266264012102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012103 Helix-turn-helix domains; Region: HTH; cl00088 266264012104 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264012105 putative effector binding pocket; other site 266264012106 dimerization interface [polypeptide binding]; other site 266264012107 high affinity sulphate transporter 1; Region: sulP; TIGR00815 266264012108 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264012109 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264012110 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264012111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012112 NMT1-like family; Region: NMT1_2; cl15260 266264012113 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266264012114 nucleoside/Zn binding site; other site 266264012115 dimer interface [polypeptide binding]; other site 266264012116 catalytic motif [active] 266264012117 Cache domain; Region: Cache_1; pfam02743 266264012118 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 266264012119 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264012120 dimerization interface [polypeptide binding]; other site 266264012121 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264012122 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264012123 dimer interface [polypeptide binding]; other site 266264012124 putative CheW interface [polypeptide binding]; other site 266264012125 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 266264012126 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 266264012127 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264012128 xanthine permease; Region: pbuX; TIGR03173 266264012129 Late embryogenesis abundant protein; Region: LEA_2; cl12118 266264012130 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 266264012131 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264012132 FAD binding site [chemical binding]; other site 266264012133 substrate binding site [chemical binding]; other site 266264012134 catalytic base [active] 266264012135 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264012136 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264012137 active site 266264012138 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 266264012139 Predicted membrane protein [Function unknown]; Region: COG1289 266264012140 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 266264012141 FlgN protein; Region: FlgN; cl09176 266264012142 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 266264012143 SAF-like; Region: SAF_2; pfam13144 266264012144 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266264012145 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 266264012146 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 266264012147 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 266264012148 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 266264012149 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 266264012150 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 266264012151 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 266264012152 FlgD Ig-like domain; Region: FlgD_ig; cl15790 266264012153 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 266264012154 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 266264012155 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 266264012156 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 266264012157 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 266264012158 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 266264012159 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 266264012160 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 266264012161 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 266264012162 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 266264012163 Flagellar L-ring protein; Region: FlgH; cl00905 266264012164 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 266264012165 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 266264012166 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 266264012167 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12712 266264012168 Rod binding protein; Region: Rod-binding; cl01626 266264012169 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266264012170 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 266264012171 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 266264012172 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 266264012173 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266264012174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264012175 metal binding site [ion binding]; metal-binding site 266264012176 active site 266264012177 I-site; other site 266264012178 Predicted transcriptional regulator [Transcription]; Region: COG2378 266264012179 WYL domain; Region: WYL; cl14852 266264012180 Short C-terminal domain; Region: SHOCT; cl01373 266264012181 MAEBL; Provisional; Region: PTZ00121 266264012182 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 266264012183 conserved hypothetical protein (fragment) 266264012184 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266264012185 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266264012186 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 266264012187 homotrimer interaction site [polypeptide binding]; other site 266264012188 putative active site [active] 266264012189 acyl-CoA dehydrogenase; partial overlap 266264012190 Bacterial PH domain; Region: DUF304; cl01348 266264012191 Glutaminase; Region: Glutaminase; cl00907 266264012192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266264012193 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 266264012194 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264012195 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 266264012196 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 266264012197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264012198 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 266264012199 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266264012200 DNA binding site [nucleotide binding] 266264012201 active site 266264012202 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266264012203 endonuclease III; Region: ENDO3c; smart00478 266264012204 minor groove reading motif; other site 266264012205 helix-hairpin-helix signature motif; other site 266264012206 substrate binding pocket [chemical binding]; other site 266264012207 active site 266264012208 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266264012209 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266264012210 DNA binding site [nucleotide binding] 266264012211 active site 266264012212 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264012213 Helix-turn-helix domains; Region: HTH; cl00088 266264012214 putative transposase OrfB; Reviewed; Region: PHA02517 266264012215 HTH-like domain; Region: HTH_21; pfam13276 266264012216 Integrase core domain; Region: rve; cl01316 266264012217 Integrase core domain; Region: rve_3; cl15866 266264012218 TniQ; Region: TniQ; pfam06527 266264012219 TniQ; Region: TniQ; pfam06527 266264012220 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 266264012221 AMP-binding enzyme; Region: AMP-binding; cl15778 266264012222 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264012223 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266264012224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264012225 Zn binding site [ion binding]; other site 266264012226 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 266264012227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264012228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264012229 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264012230 active site 266264012231 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266264012232 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266264012233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012234 putative substrate translocation pore; other site 266264012235 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266264012236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012237 NMT1-like family; Region: NMT1_2; cl15260 266264012238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264012239 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264012240 trimer interface [polypeptide binding]; other site 266264012241 eyelet of channel; other site 266264012242 acyl-CoA synthetase; Validated; Region: PRK06188 266264012243 AMP-binding enzyme; Region: AMP-binding; cl15778 266264012244 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264012245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012246 NMT1-like family; Region: NMT1_2; cl15260 266264012247 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264012248 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264012249 active site 266264012250 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264012251 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264012252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012253 NMT1-like family; Region: NMT1_2; cl15260 266264012254 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266264012255 Helix-turn-helix domains; Region: HTH; cl00088 266264012256 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 266264012257 putative dimerization interface [polypeptide binding]; other site 266264012258 putative substrate binding pocket [chemical binding]; other site 266264012259 lipase chaperone; Provisional; Region: PRK01294 266264012260 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 266264012261 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 266264012262 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264012263 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264012264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012265 NMT1-like family; Region: NMT1_2; cl15260 266264012266 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266264012267 AMP-binding enzyme; Region: AMP-binding; cl15778 266264012268 AMP-binding enzyme; Region: AMP-binding; cl15778 266264012269 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012270 Helix-turn-helix domains; Region: HTH; cl00088 266264012271 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264012272 putative dimerization interface [polypeptide binding]; other site 266264012273 enoyl-CoA hydratase; Provisional; Region: PRK06688 266264012274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264012275 substrate binding site [chemical binding]; other site 266264012276 oxyanion hole (OAH) forming residues; other site 266264012277 trimer interface [polypeptide binding]; other site 266264012278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012279 NMT1-like family; Region: NMT1_2; cl15260 266264012280 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266264012281 AMP-binding enzyme; Region: AMP-binding; cl15778 266264012282 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264012283 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264012284 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264012285 active site 266264012286 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264012287 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264012288 active site 266264012289 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 266264012290 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264012291 active site 266264012292 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264012293 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264012294 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264012295 enoyl-CoA hydratase; Region: PLN02864 266264012296 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 266264012297 dimer interaction site [polypeptide binding]; other site 266264012298 substrate-binding tunnel; other site 266264012299 active site 266264012300 catalytic site [active] 266264012301 substrate binding site [chemical binding]; other site 266264012302 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264012303 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264012304 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264012305 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264012306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012307 Helix-turn-helix domains; Region: HTH; cl00088 266264012308 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264012309 putative dimerization interface [polypeptide binding]; other site 266264012310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012311 NMT1-like family; Region: NMT1_2; cl15260 266264012312 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266264012313 active site 266264012314 catalytic site [active] 266264012315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012316 NMT1-like family; Region: NMT1_2; cl15260 266264012317 Peptidase M15; Region: Peptidase_M15_3; cl01194 266264012318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 266264012319 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266264012320 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266264012321 Helix-turn-helix domains; Region: HTH; cl00088 266264012322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264012323 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264012324 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264012325 active site 266264012326 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264012327 AMP-binding enzyme; Region: AMP-binding; cl15778 266264012328 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264012329 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266264012330 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266264012331 dimer interface [polypeptide binding]; other site 266264012332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264012333 catalytic residue [active] 266264012334 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 266264012335 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266264012336 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264012337 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 266264012338 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264012339 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264012340 catalytic loop [active] 266264012341 iron binding site [ion binding]; other site 266264012342 Uncharacterized conserved protein [Function unknown]; Region: COG1739 266264012343 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 266264012344 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 266264012345 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 266264012346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264012347 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266264012348 RES domain; Region: RES; cl02411 266264012349 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 266264012350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012351 NMT1-like family; Region: NMT1_2; cl15260 266264012352 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 266264012353 Helix-turn-helix domains; Region: HTH; cl00088 266264012354 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266264012355 putative dimerization interface [polypeptide binding]; other site 266264012356 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264012357 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264012358 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266264012359 Outer membrane efflux protein; Region: OEP; pfam02321 266264012360 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264012361 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264012362 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264012363 E3 interaction surface; other site 266264012364 lipoyl attachment site [posttranslational modification]; other site 266264012365 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264012366 heavy metal cation tricomponent efflux pump HmvA (CzcA-like) 266264012367 heavy metal cation tricomponent efflux pump HmvA (CzcA-like) 266264012368 GAF domain; Region: GAF_2; pfam13185 266264012369 GAF domain; Region: GAF; cl15785 266264012370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264012371 metal binding site [ion binding]; metal-binding site 266264012372 active site 266264012373 I-site; other site 266264012374 Tannase and feruloyl esterase; Region: Tannase; pfam07519 266264012375 potential protein location (hypothetical protein) that overlaps protein (tannase and feruloyl esterase (alpha/beta hydrolase family)) 266264012376 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264012377 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 266264012378 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266264012379 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264012380 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 266264012381 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264012382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264012383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264012384 S-adenosylmethionine binding site [chemical binding]; other site 266264012385 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 266264012386 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266264012387 dimer interface [polypeptide binding]; other site 266264012388 3,8-divinyl protochlorophyllide a 8-vinyl reductase; Region: PLN02657 266264012389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264012390 TIGR01777 family protein; Region: yfcH 266264012391 NAD(P) binding site [chemical binding]; other site 266264012392 active site 266264012393 Protein of unknown function, DUF393; Region: DUF393; cl01136 266264012394 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 266264012395 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 266264012396 putative NAD(P) binding site [chemical binding]; other site 266264012397 active site 266264012398 DoxX-like family; Region: DoxX_3; pfam13781 266264012399 Predicted transcriptional regulators [Transcription]; Region: COG1510 266264012400 Helix-turn-helix domains; Region: HTH; cl00088 266264012401 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266264012402 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266264012403 active site 266264012404 non-prolyl cis peptide bond; other site 266264012405 NMT1-like family; Region: NMT1_2; cl15260 266264012406 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266264012407 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 266264012408 Walker A/P-loop; other site 266264012409 ATP binding site [chemical binding]; other site 266264012410 Q-loop/lid; other site 266264012411 ABC transporter signature motif; other site 266264012412 Walker B; other site 266264012413 D-loop; other site 266264012414 H-loop/switch region; other site 266264012415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264012416 dimer interface [polypeptide binding]; other site 266264012417 conserved gate region; other site 266264012418 ABC-ATPase subunit interface; other site 266264012419 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266264012420 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266264012421 Flavin binding site [chemical binding]; other site 266264012422 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 266264012423 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264012424 active site residue [active] 266264012425 selenophosphate synthetase; Provisional; Region: PRK00943 266264012426 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 266264012427 dimerization interface [polypeptide binding]; other site 266264012428 putative ATP binding site [chemical binding]; other site 266264012429 Rhomboid family; Region: Rhomboid; cl11446 266264012430 LysE type translocator; Region: LysE; cl00565 266264012431 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 266264012432 Helix-turn-helix domains; Region: HTH; cl00088 266264012433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264012434 dimerization interface [polypeptide binding]; other site 266264012435 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 266264012436 Chromate transporter; Region: Chromate_transp; pfam02417 266264012437 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 266264012438 Chromate transporter; Region: Chromate_transp; pfam02417 266264012439 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 266264012440 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264012441 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 266264012442 Cytochrome P450; Region: p450; pfam00067 266264012443 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266264012444 FMN binding site [chemical binding]; other site 266264012445 active site 266264012446 substrate binding site [chemical binding]; other site 266264012447 catalytic residue [active] 266264012448 LysR family transcriptional regulator; Provisional; Region: PRK14997 266264012449 Helix-turn-helix domains; Region: HTH; cl00088 266264012450 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264012451 putative effector binding pocket; other site 266264012452 dimerization interface [polypeptide binding]; other site 266264012453 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 266264012454 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264012455 Helix-turn-helix domains; Region: HTH; cl00088 266264012456 short chain dehydrogenase; Provisional; Region: PRK12937 266264012457 classical (c) SDRs; Region: SDR_c; cd05233 266264012458 NAD(P) binding site [chemical binding]; other site 266264012459 active site 266264012460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012461 Helix-turn-helix domains; Region: HTH; cl00088 266264012462 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264012463 putative effector binding pocket; other site 266264012464 dimerization interface [polypeptide binding]; other site 266264012465 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264012466 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 266264012467 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264012468 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 266264012469 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 266264012470 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266264012471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012472 active site 266264012473 phosphorylation site [posttranslational modification] 266264012474 intermolecular recognition site; other site 266264012475 dimerization interface [polypeptide binding]; other site 266264012476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264012477 DNA binding site [nucleotide binding] 266264012478 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 266264012479 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264012480 dimerization interface [polypeptide binding]; other site 266264012481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264012482 dimer interface [polypeptide binding]; other site 266264012483 phosphorylation site [posttranslational modification] 266264012484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264012485 ATP binding site [chemical binding]; other site 266264012486 Mg2+ binding site [ion binding]; other site 266264012487 G-X-G motif; other site 266264012488 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 266264012489 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264012490 Helix-turn-helix domains; Region: HTH; cl00088 266264012491 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266264012492 dihydropyrimidinase; Provisional; Region: PRK13404 266264012493 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 266264012494 tetramer interface [polypeptide binding]; other site 266264012495 active site 266264012496 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266264012497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012498 D-galactonate transporter; Region: 2A0114; TIGR00893 266264012499 putative substrate translocation pore; other site 266264012500 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264012501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264012502 DNA-binding site [nucleotide binding]; DNA binding site 266264012503 FCD domain; Region: FCD; cl11656 266264012504 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266264012505 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264012506 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266264012507 homotrimer interaction site [polypeptide binding]; other site 266264012508 putative active site [active] 266264012509 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264012510 classical (c) SDRs; Region: SDR_c; cd05233 266264012511 NAD(P) binding site [chemical binding]; other site 266264012512 active site 266264012513 Helix-turn-helix domains; Region: HTH; cl00088 266264012514 LysR family transcriptional regulator; Provisional; Region: PRK14997 266264012515 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264012516 putative effector binding pocket; other site 266264012517 dimerization interface [polypeptide binding]; other site 266264012518 Protein of unknown function (DUF535); Region: DUF535; cl01128 266264012519 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266264012520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264012521 DNA-binding site [nucleotide binding]; DNA binding site 266264012522 UTRA domain; Region: UTRA; cl01230 266264012523 hypothetical protein; Validated; Region: PRK07586 266264012524 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264012525 PYR/PP interface [polypeptide binding]; other site 266264012526 dimer interface [polypeptide binding]; other site 266264012527 TPP binding site [chemical binding]; other site 266264012528 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266264012529 TPP-binding site [chemical binding]; other site 266264012530 dimer interface [polypeptide binding]; other site 266264012531 Uncharacterized conserved protein [Function unknown]; Region: COG3777 266264012532 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264012533 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 266264012534 putative active site [active] 266264012535 putative catalytic site [active] 266264012536 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266264012537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264012538 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264012539 active site 266264012540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012541 NMT1-like family; Region: NMT1_2; cl15260 266264012542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012543 Helix-turn-helix domains; Region: HTH; cl00088 266264012544 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264012545 putative dimerization interface [polypeptide binding]; other site 266264012546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264012547 NAD(P) binding site [chemical binding]; other site 266264012548 short chain dehydrogenase; Provisional; Region: PRK07060 266264012549 active site 266264012550 PrkA family serine protein kinase; Provisional; Region: PRK15455 266264012551 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 266264012552 Uncharacterized conserved protein [Function unknown]; Region: COG2718 266264012553 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266264012554 SpoVR family protein; Provisional; Region: PRK11767 266264012555 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 266264012556 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264012557 DNA binding residues [nucleotide binding] 266264012558 dimerization interface [polypeptide binding]; other site 266264012559 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264012560 LysE type translocator; Region: LysE; cl00565 266264012561 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264012562 catalytic core [active] 266264012563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012564 NMT1-like family; Region: NMT1_2; cl15260 266264012565 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264012566 Helix-turn-helix domains; Region: HTH; cl00088 266264012567 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266264012568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264012569 CoA-ligase; Region: Ligase_CoA; cl02894 266264012570 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264012571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012572 NMT1-like family; Region: NMT1_2; cl15260 266264012573 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264012574 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266264012575 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264012576 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264012577 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266264012578 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264012579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012580 NMT1-like family; Region: NMT1_2; cl15260 266264012581 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 266264012582 active site 266264012583 catalytic site [active] 266264012584 substrate binding site [chemical binding]; other site 266264012585 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 266264012586 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266264012587 GIY-YIG motif/motif A; other site 266264012588 active site 266264012589 catalytic site [active] 266264012590 putative DNA binding site [nucleotide binding]; other site 266264012591 metal binding site [ion binding]; metal-binding site 266264012592 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 266264012593 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264012594 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264012595 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266264012596 Protein export membrane protein; Region: SecD_SecF; cl14618 266264012597 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264012598 Arginase family; Region: Arginase; cl00306 266264012599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012600 NMT1-like family; Region: NMT1_2; cl15260 266264012601 hypothetical protein 266264012602 AAA domain; Region: AAA_22; pfam13401 266264012603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264012604 Walker A motif; other site 266264012605 ATP binding site [chemical binding]; other site 266264012606 Walker B motif; other site 266264012607 arginine finger; other site 266264012608 Integrase core domain; Region: rve; cl01316 266264012609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012610 NMT1-like family; Region: NMT1_2; cl15260 266264012611 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266264012612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012613 active site 266264012614 phosphorylation site [posttranslational modification] 266264012615 intermolecular recognition site; other site 266264012616 dimerization interface [polypeptide binding]; other site 266264012617 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264012618 DNA binding site [nucleotide binding] 266264012619 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266264012620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264012621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264012622 dimer interface [polypeptide binding]; other site 266264012623 phosphorylation site [posttranslational modification] 266264012624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264012625 ATP binding site [chemical binding]; other site 266264012626 Mg2+ binding site [ion binding]; other site 266264012627 G-X-G motif; other site 266264012628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264012629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012630 putative substrate translocation pore; other site 266264012631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012632 Helix-turn-helix domains; Region: HTH; cl00088 266264012633 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 266264012634 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 266264012635 catalytic triad [active] 266264012636 transcriptional regulator RcsB; Provisional; Region: PRK10840 266264012637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012638 active site 266264012639 phosphorylation site [posttranslational modification] 266264012640 intermolecular recognition site; other site 266264012641 dimerization interface [polypeptide binding]; other site 266264012642 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264012643 DNA binding residues [nucleotide binding] 266264012644 dimerization interface [polypeptide binding]; other site 266264012645 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012646 Helix-turn-helix domains; Region: HTH; cl00088 266264012647 Transposase IS3/IS911 (fragment) 266264012648 putative transposase OrfB; Reviewed; Region: PHA02517 266264012649 HTH-like domain; Region: HTH_21; pfam13276 266264012650 Integrase core domain; Region: rve; cl01316 266264012651 Integrase core domain; Region: rve_3; cl15866 266264012652 Helix-turn-helix domains; Region: HTH; cl00088 266264012653 Transposase IS3/IS911 (fragment) 266264012654 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 266264012655 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 266264012656 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264012657 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264012658 ligand binding site [chemical binding]; other site 266264012659 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264012660 putative switch regulator; other site 266264012661 non-specific DNA interactions [nucleotide binding]; other site 266264012662 DNA binding site [nucleotide binding] 266264012663 sequence specific DNA binding site [nucleotide binding]; other site 266264012664 putative cAMP binding site [chemical binding]; other site 266264012665 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264012666 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 266264012667 metabolite-proton symporter; Region: 2A0106; TIGR00883 266264012668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012670 TIGR03545 family protein; Region: TIGR03545 266264012671 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266264012672 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266264012673 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266264012674 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266264012675 AsmA-like C-terminal region; Region: AsmA_2; cl15864 266264012676 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 266264012677 ligand binding site [chemical binding]; other site 266264012678 Rubredoxin [Energy production and conversion]; Region: COG1773 266264012679 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266264012680 iron binding site [ion binding]; other site 266264012681 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 266264012682 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264012683 Cytochrome c; Region: Cytochrom_C; cl11414 266264012684 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266264012685 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 266264012686 D-pathway; other site 266264012687 Low-spin heme binding site [chemical binding]; other site 266264012688 Putative water exit pathway; other site 266264012689 Binuclear center (active site) [active] 266264012690 K-pathway; other site 266264012691 Putative proton exit pathway; other site 266264012692 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 266264012693 Subunit I/III interface [polypeptide binding]; other site 266264012694 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 266264012695 Subunit I/III interface [polypeptide binding]; other site 266264012696 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 266264012697 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 266264012698 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264012699 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266264012700 tetramerization interface [polypeptide binding]; other site 266264012701 NAD(P) binding site [chemical binding]; other site 266264012702 catalytic residues [active] 266264012703 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 266264012704 MatE; Region: MatE; cl10513 266264012705 MatE; Region: MatE; cl10513 266264012706 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266264012707 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266264012708 Helix-turn-helix domains; Region: HTH; cl00088 266264012709 Peptidase M66; Region: Peptidase_M66; pfam10462 266264012710 Response regulator receiver domain; Region: Response_reg; pfam00072 266264012711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012712 active site 266264012713 phosphorylation site [posttranslational modification] 266264012714 intermolecular recognition site; other site 266264012715 dimerization interface [polypeptide binding]; other site 266264012716 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264012717 metal binding site [ion binding]; metal-binding site 266264012718 active site 266264012719 I-site; other site 266264012720 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 266264012721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012722 active site 266264012723 phosphorylation site [posttranslational modification] 266264012724 intermolecular recognition site; other site 266264012725 dimerization interface [polypeptide binding]; other site 266264012726 CheB methylesterase; Region: CheB_methylest; pfam01339 266264012727 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264012728 putative binding surface; other site 266264012729 active site 266264012730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264012731 ATP binding site [chemical binding]; other site 266264012732 Mg2+ binding site [ion binding]; other site 266264012733 G-X-G motif; other site 266264012734 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266264012735 Response regulator receiver domain; Region: Response_reg; pfam00072 266264012736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012737 active site 266264012738 phosphorylation site [posttranslational modification] 266264012739 intermolecular recognition site; other site 266264012740 dimerization interface [polypeptide binding]; other site 266264012741 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266264012742 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266264012743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264012744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266264012745 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266264012746 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264012747 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266264012748 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264012749 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264012750 dimer interface [polypeptide binding]; other site 266264012751 putative CheW interface [polypeptide binding]; other site 266264012752 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264012753 metal binding site [ion binding]; metal-binding site 266264012754 active site 266264012755 I-site; other site 266264012756 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264012757 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264012758 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 266264012759 putative ligand binding site [chemical binding]; other site 266264012760 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264012761 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264012762 Walker A/P-loop; other site 266264012763 ATP binding site [chemical binding]; other site 266264012764 Q-loop/lid; other site 266264012765 ABC transporter signature motif; other site 266264012766 Walker B; other site 266264012767 D-loop; other site 266264012768 H-loop/switch region; other site 266264012769 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264012770 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264012771 Walker A/P-loop; other site 266264012772 ATP binding site [chemical binding]; other site 266264012773 Q-loop/lid; other site 266264012774 ABC transporter signature motif; other site 266264012775 Walker B; other site 266264012776 D-loop; other site 266264012777 H-loop/switch region; other site 266264012778 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264012779 TM-ABC transporter signature motif; other site 266264012780 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264012781 TM-ABC transporter signature motif; other site 266264012782 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264012783 Helix-turn-helix domains; Region: HTH; cl00088 266264012784 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264012785 classical (c) SDRs; Region: SDR_c; cd05233 266264012786 NAD(P) binding site [chemical binding]; other site 266264012787 active site 266264012788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012789 NMT1-like family; Region: NMT1_2; cl15260 266264012790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012791 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264012792 putative substrate translocation pore; other site 266264012793 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 266264012794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264012795 dimer interface [polypeptide binding]; other site 266264012796 phosphorylation site [posttranslational modification] 266264012797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264012798 ATP binding site [chemical binding]; other site 266264012799 Mg2+ binding site [ion binding]; other site 266264012800 G-X-G motif; other site 266264012801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012802 active site 266264012803 phosphorylation site [posttranslational modification] 266264012804 intermolecular recognition site; other site 266264012805 dimerization interface [polypeptide binding]; other site 266264012806 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264012807 putative binding surface; other site 266264012808 active site 266264012809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264012810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012811 active site 266264012812 phosphorylation site [posttranslational modification] 266264012813 intermolecular recognition site; other site 266264012814 dimerization interface [polypeptide binding]; other site 266264012815 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264012816 DNA binding residues [nucleotide binding] 266264012817 dimerization interface [polypeptide binding]; other site 266264012818 Sensors of blue-light using FAD; Region: BLUF; cl04855 266264012819 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266264012820 GTP cyclohydrolase I; Provisional; Region: PLN03044 266264012821 active site 266264012822 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 266264012823 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266264012824 transmembrane helices; other site 266264012825 Transglycosylase; Region: Transgly; cl07896 266264012826 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266264012827 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264012828 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266264012829 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 266264012830 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 266264012831 Fibronectin type III-like domain; Region: Fn3-like; cl15273 266264012832 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 266264012833 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 266264012834 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 266264012835 Secretin and TonB N terminus short domain; Region: STN; cl06624 266264012836 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264012837 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264012838 N-terminal plug; other site 266264012839 ligand-binding site [chemical binding]; other site 266264012840 fec operon regulator FecR; Reviewed; Region: PRK09774 266264012841 FecR protein; Region: FecR; pfam04773 266264012842 RNA polymerase sigma factor; Provisional; Region: PRK12528 266264012843 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264012844 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264012845 DNA binding residues [nucleotide binding] 266264012846 Response regulator receiver domain; Region: Response_reg; pfam00072 266264012847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012848 active site 266264012849 phosphorylation site [posttranslational modification] 266264012850 intermolecular recognition site; other site 266264012851 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264012852 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266264012853 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264012854 Helix-turn-helix domains; Region: HTH; cl00088 266264012855 Integrase core domain; Region: rve; cl01316 266264012856 Fimbrial protein; Region: Fimbrial; cl01416 266264012857 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 266264012858 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 266264012859 Cupin domain; Region: Cupin_2; cl09118 266264012860 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266264012861 oligomeric interface; other site 266264012862 putative active site [active] 266264012863 homodimer interface [polypeptide binding]; other site 266264012864 shikimate kinase; Reviewed; Region: aroK; PRK00131 266264012865 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266264012866 ADP binding site [chemical binding]; other site 266264012867 magnesium binding site [ion binding]; other site 266264012868 putative shikimate binding site; other site 266264012869 benzoate transport; Region: 2A0115; TIGR00895 266264012870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012872 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266264012873 Helix-turn-helix domains; Region: HTH; cl00088 266264012874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264012875 dimerization interface [polypeptide binding]; other site 266264012876 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 266264012877 multimer interface [polypeptide binding]; other site 266264012878 heterodimer interface [polypeptide binding]; other site 266264012879 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 266264012880 active site 266264012881 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 266264012882 heterodimer interface [polypeptide binding]; other site 266264012883 active site 266264012884 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 266264012885 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 266264012886 tetramer interface [polypeptide binding]; other site 266264012887 active site 266264012888 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264012889 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266264012890 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264012891 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 266264012892 Cupin domain; Region: Cupin_2; cl09118 266264012893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264012894 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 266264012895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264012896 Survival protein SurE; Region: SurE; cl00448 266264012897 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264012898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012899 Helix-turn-helix domains; Region: HTH; cl00088 266264012900 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 266264012901 putative substrate binding pocket [chemical binding]; other site 266264012902 putative dimerization interface [polypeptide binding]; other site 266264012903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012904 MFS transport protein AraJ; Provisional; Region: PRK10091 266264012905 putative substrate translocation pore; other site 266264012906 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 266264012907 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 266264012908 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 266264012909 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 266264012910 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264012911 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 266264012912 dimer interface [polypeptide binding]; other site 266264012913 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264012914 metal binding site [ion binding]; metal-binding site 266264012915 Cytochrome c; Region: Cytochrom_C; cl11414 266264012916 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 266264012917 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 266264012918 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266264012919 Helix-turn-helix domains; Region: HTH; cl00088 266264012920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264012921 dimerization interface [polypeptide binding]; other site 266264012922 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 266264012923 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 266264012924 active site 266264012925 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 266264012926 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264012927 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264012928 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264012929 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264012930 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264012931 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264012932 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264012933 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264012934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012935 active site 266264012936 phosphorylation site [posttranslational modification] 266264012937 intermolecular recognition site; other site 266264012938 dimerization interface [polypeptide binding]; other site 266264012939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264012940 DNA binding site [nucleotide binding] 266264012941 sensor protein QseC; Provisional; Region: PRK10337 266264012942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264012943 dimer interface [polypeptide binding]; other site 266264012944 phosphorylation site [posttranslational modification] 266264012945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264012946 ATP binding site [chemical binding]; other site 266264012947 Mg2+ binding site [ion binding]; other site 266264012948 G-X-G motif; other site 266264012949 EamA-like transporter family; Region: EamA; cl01037 266264012950 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264012951 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264012952 catalytic residues [active] 266264012953 catalytic nucleophile [active] 266264012954 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264012955 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264012956 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264012957 Synaptic Site I dimer interface [polypeptide binding]; other site 266264012958 DNA binding site [nucleotide binding] 266264012959 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264012960 DNA-binding interface [nucleotide binding]; DNA binding site 266264012961 TniQ; Region: TniQ; pfam06527 266264012962 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264012963 Integrase core domain; Region: rve; cl01316 266264012964 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266264012965 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266264012966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012967 NMT1-like family; Region: NMT1_2; cl15260 266264012968 GAF domain; Region: GAF_2; pfam13185 266264012969 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266264012970 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266264012971 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264012972 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 266264012973 putative C-terminal domain interface [polypeptide binding]; other site 266264012974 putative GSH binding site (G-site) [chemical binding]; other site 266264012975 putative dimer interface [polypeptide binding]; other site 266264012976 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 266264012977 putative N-terminal domain interface [polypeptide binding]; other site 266264012978 putative dimer interface [polypeptide binding]; other site 266264012979 putative substrate binding pocket (H-site) [chemical binding]; other site 266264012980 transcriptional regulator; Provisional; Region: PRK10632 266264012981 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 266264012982 putative effector binding pocket; other site 266264012983 putative dimerization interface [polypeptide binding]; other site 266264012984 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266264012985 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 266264012986 Cytochrome C biogenesis protein; Region: CcmH; cl01179 266264012987 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 266264012988 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 266264012989 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 266264012990 catalytic residues [active] 266264012991 central insert; other site 266264012992 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266264012993 CcmE; Region: CcmE; cl00994 266264012994 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266264012995 CcmB protein; Region: CcmB; cl01016 266264012996 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 266264012997 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264012998 Walker A/P-loop; other site 266264012999 ATP binding site [chemical binding]; other site 266264013000 Q-loop/lid; other site 266264013001 ABC transporter signature motif; other site 266264013002 Walker B; other site 266264013003 D-loop; other site 266264013004 H-loop/switch region; other site 266264013005 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 266264013006 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 266264013007 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 266264013008 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 266264013009 [4Fe-4S] binding site [ion binding]; other site 266264013010 molybdopterin cofactor binding site; other site 266264013011 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 266264013012 molybdopterin cofactor binding site; other site 266264013013 NapD protein; Region: NapD; cl01163 266264013014 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 266264013015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013016 NMT1-like family; Region: NMT1_2; cl15260 266264013017 acyl-CoA synthetase; Validated; Region: PRK06178 266264013018 AMP-binding enzyme; Region: AMP-binding; cl15778 266264013019 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264013020 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266264013021 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264013022 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264013023 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266264013024 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264013025 carboxyltransferase (CT) interaction site; other site 266264013026 biotinylation site [posttranslational modification]; other site 266264013027 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 266264013028 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266264013029 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266264013030 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266264013031 Helix-turn-helix domains; Region: HTH; cl00088 266264013032 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264013033 dimerization interface [polypeptide binding]; other site 266264013034 substrate binding pocket [chemical binding]; other site 266264013035 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264013036 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013037 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264013038 active site 2 [active] 266264013039 active site 1 [active] 266264013040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013041 NMT1-like family; Region: NMT1_2; cl15260 266264013042 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264013043 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264013044 active site 266264013045 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264013046 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264013047 classical (c) SDRs; Region: SDR_c; cd05233 266264013048 NAD(P) binding site [chemical binding]; other site 266264013049 active site 266264013050 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 266264013051 NMT1-like family; Region: NMT1_2; cl15260 266264013052 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266264013053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013054 putative substrate translocation pore; other site 266264013055 conserved hypothetical protein, partial overlap 266264013056 potential protein location (conserved hypothetical protein) that overlaps protein (hypothetical protein) 266264013057 GYD domain; Region: GYD; cl01743 266264013058 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 266264013059 dimer interface [polypeptide binding]; other site 266264013060 Alkaline phosphatase homologues; Region: alkPPc; smart00098 266264013061 active site 266264013062 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 266264013063 dimer interface [polypeptide binding]; other site 266264013064 Alkaline phosphatase homologues; Region: alkPPc; smart00098 266264013065 active site 266264013066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 266264013067 Protein of unknown function (DUF330); Region: DUF330; cl01135 266264013068 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 266264013069 mce related protein; Region: MCE; pfam02470 266264013070 mce related protein; Region: MCE; pfam02470 266264013071 mce related protein; Region: MCE; pfam02470 266264013072 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 266264013073 Paraquat-inducible protein A; Region: PqiA; pfam04403 266264013074 Paraquat-inducible protein A; Region: PqiA; pfam04403 266264013075 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264013076 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266264013077 DNA binding residues [nucleotide binding] 266264013078 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 266264013079 putative active site [active] 266264013080 putative FMN binding site [chemical binding]; other site 266264013081 putative substrate binding site [chemical binding]; other site 266264013082 putative catalytic residue [active] 266264013083 LysR family transcriptional regulator; Provisional; Region: PRK14997 266264013084 Helix-turn-helix domains; Region: HTH; cl00088 266264013085 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 266264013086 putative effector binding pocket; other site 266264013087 putative dimerization interface [polypeptide binding]; other site 266264013088 Pirin-related protein [General function prediction only]; Region: COG1741 266264013089 Cupin domain; Region: Cupin_2; cl09118 266264013090 DoxX; Region: DoxX; cl00976 266264013091 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264013092 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264013093 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264013094 trimer interface [polypeptide binding]; other site 266264013095 eyelet of channel; other site 266264013096 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 266264013097 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264013098 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013099 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264013100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264013101 DNA-binding site [nucleotide binding]; DNA binding site 266264013102 FCD domain; Region: FCD; cl11656 266264013103 enoyl-CoA hydratase; Provisional; Region: PRK06144 266264013104 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264013105 substrate binding site [chemical binding]; other site 266264013106 oxyanion hole (OAH) forming residues; other site 266264013107 trimer interface [polypeptide binding]; other site 266264013108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013109 NMT1-like family; Region: NMT1_2; cl15260 266264013110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264013111 Helix-turn-helix domains; Region: HTH; cl00088 266264013112 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266264013113 FMN binding site [chemical binding]; other site 266264013114 active site 266264013115 substrate binding site [chemical binding]; other site 266264013116 catalytic residue [active] 266264013117 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 266264013118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264013119 Walker A motif; other site 266264013120 ATP binding site [chemical binding]; other site 266264013121 Walker B motif; other site 266264013122 arginine finger; other site 266264013123 Helix-turn-helix domains; Region: HTH; cl00088 266264013124 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266264013125 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266264013126 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 266264013127 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266264013128 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 266264013129 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 266264013130 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266264013131 intersubunit interface [polypeptide binding]; other site 266264013132 active site 266264013133 Zn2+ binding site [ion binding]; other site 266264013134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013135 NMT1-like family; Region: NMT1_2; cl15260 266264013136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264013137 non-specific DNA binding site [nucleotide binding]; other site 266264013138 salt bridge; other site 266264013139 sequence-specific DNA binding site [nucleotide binding]; other site 266264013140 Cupin domain; Region: Cupin_2; cl09118 266264013141 MOSC domain; Region: MOSC; pfam03473 266264013142 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266264013143 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266264013144 FMN-binding pocket [chemical binding]; other site 266264013145 flavin binding motif; other site 266264013146 phosphate binding motif [ion binding]; other site 266264013147 beta-alpha-beta structure motif; other site 266264013148 NAD binding pocket [chemical binding]; other site 266264013149 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 266264013150 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264013151 catalytic residue [active] 266264013152 pyridoxamine kinase; Validated; Region: PRK05756 266264013153 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 266264013154 dimer interface [polypeptide binding]; other site 266264013155 pyridoxal binding site [chemical binding]; other site 266264013156 ATP binding site [chemical binding]; other site 266264013157 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 266264013158 hypothetical protein 266264013159 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 266264013160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264013161 DNA-binding site [nucleotide binding]; DNA binding site 266264013162 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264013163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264013164 homodimer interface [polypeptide binding]; other site 266264013165 catalytic residue [active] 266264013166 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264013167 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264013168 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264013169 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264013170 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264013171 Helix-turn-helix domains; Region: HTH; cl00088 266264013172 Integrase core domain; Region: rve; cl01316 266264013173 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264013174 Protein of unknown function (DUF2880); Region: DUF2880; pfam11082 266264013175 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 266264013176 NifQ; Region: NifQ; pfam04891 266264013177 Helix-turn-helix domains; Region: HTH; cl00088 266264013178 non-specific DNA interactions [nucleotide binding]; other site 266264013179 DNA binding site [nucleotide binding] 266264013180 sequence specific DNA binding site [nucleotide binding]; other site 266264013181 putative cAMP binding site [chemical binding]; other site 266264013182 DNA Polymerase Y-family; Region: PolY_like; cd03468 266264013183 active site 266264013184 DNA binding site [nucleotide binding] 266264013185 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 266264013186 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 266264013187 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 266264013188 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266264013189 generic binding surface II; other site 266264013190 generic binding surface I; other site 266264013191 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266264013192 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266264013193 dimer interface [polypeptide binding]; other site 266264013194 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266264013195 catalytic triad [active] 266264013196 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 266264013197 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264013198 E3 interaction surface; other site 266264013199 lipoyl attachment site [posttranslational modification]; other site 266264013200 e3 binding domain; Region: E3_binding; pfam02817 266264013201 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 266264013202 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266264013203 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266264013204 alpha subunit interface [polypeptide binding]; other site 266264013205 TPP binding site [chemical binding]; other site 266264013206 heterodimer interface [polypeptide binding]; other site 266264013207 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266264013208 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 266264013209 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266264013210 tetramer interface [polypeptide binding]; other site 266264013211 TPP-binding site [chemical binding]; other site 266264013212 heterodimer interface [polypeptide binding]; other site 266264013213 phosphorylation loop region [posttranslational modification] 266264013214 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 266264013215 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264013216 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264013217 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266264013218 NMT1-like family; Region: NMT1_2; cl15260 266264013219 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264013220 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266264013221 Walker A/P-loop; other site 266264013222 ATP binding site [chemical binding]; other site 266264013223 Q-loop/lid; other site 266264013224 ABC transporter signature motif; other site 266264013225 Walker B; other site 266264013226 D-loop; other site 266264013227 H-loop/switch region; other site 266264013228 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264013229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266264013230 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 266264013231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264013232 S-adenosylmethionine binding site [chemical binding]; other site 266264013233 major facilitator superfamily transporter; Provisional; Region: PRK05122 266264013234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013235 putative substrate translocation pore; other site 266264013236 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264013237 Helix-turn-helix domains; Region: HTH; cl00088 266264013238 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264013239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264013240 metal binding site [ion binding]; metal-binding site 266264013241 active site 266264013242 I-site; other site 266264013243 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 266264013244 active site 266264013245 oxalacetate binding site [chemical binding]; other site 266264013246 citrylCoA binding site [chemical binding]; other site 266264013247 coenzyme A binding site [chemical binding]; other site 266264013248 catalytic triad [active] 266264013249 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264013250 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013252 NMT1-like family; Region: NMT1_2; cl15260 266264013253 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 266264013254 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 266264013255 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 266264013256 Active site cavity [active] 266264013257 catalytic acid [active] 266264013258 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266264013259 active site lid residues [active] 266264013260 substrate binding pocket [chemical binding]; other site 266264013261 catalytic residues [active] 266264013262 substrate-Mg2+ binding site; other site 266264013263 aspartate-rich region 1; other site 266264013264 aspartate-rich region 2; other site 266264013265 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266264013266 DNA-binding site [nucleotide binding]; DNA binding site 266264013267 RNA-binding motif; other site 266264013268 Winged helix-turn helix; Region: HTH_29; pfam13551 266264013269 Integrase core domain; Region: rve; cl01316 266264013270 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266264013271 Integrase core domain; Region: rve_3; cl15866 266264013272 Transposase domain (DUF772); Region: DUF772; pfam05598 266264013273 DDE superfamily endonuclease; Region: DDE_4; cl15789 266264013274 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 266264013275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266264013276 TM1410 hypothetical-related protein; Region: DUF297; cl00997 266264013277 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 266264013278 putative active site [active] 266264013279 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 266264013280 Tetratricopeptide repeat; Region: TPR_15; pfam13429 266264013281 TolB amino-terminal domain; Region: TolB_N; cl00639 266264013282 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 266264013283 GAF domain; Region: GAF; cl15785 266264013284 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 266264013285 Predicted membrane protein [Function unknown]; Region: COG4267 266264013286 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264013287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013288 active site 266264013289 phosphorylation site [posttranslational modification] 266264013290 intermolecular recognition site; other site 266264013291 dimerization interface [polypeptide binding]; other site 266264013292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264013293 DNA binding site [nucleotide binding] 266264013294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 266264013295 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264013296 FecR protein; Region: FecR; pfam04773 266264013297 CHASE2 domain; Region: CHASE2; cl01732 266264013298 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266264013299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264013300 dimer interface [polypeptide binding]; other site 266264013301 phosphorylation site [posttranslational modification] 266264013302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264013303 ATP binding site [chemical binding]; other site 266264013304 Mg2+ binding site [ion binding]; other site 266264013305 G-X-G motif; other site 266264013306 VacJ like lipoprotein; Region: VacJ; cl01073 266264013307 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 266264013308 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 266264013309 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 266264013310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264013311 FeS/SAM binding site; other site 266264013312 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 266264013313 LytB protein; Region: LYTB; cl00507 266264013314 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 266264013315 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 266264013316 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 266264013317 putative NADP binding site [chemical binding]; other site 266264013318 putative substrate binding site [chemical binding]; other site 266264013319 active site 266264013320 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 266264013321 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266264013322 active site 266264013323 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266264013324 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 266264013325 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 266264013326 dimerization interface [polypeptide binding]; other site 266264013327 putative active cleft [active] 266264013328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013329 Helix-turn-helix domains; Region: HTH; cl00088 266264013330 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013331 dimerization interface [polypeptide binding]; other site 266264013332 putative transporter; Provisional; Region: PRK10504 266264013333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013334 putative substrate translocation pore; other site 266264013335 Helix-turn-helix domains; Region: HTH; cl00088 266264013336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013337 dimerization interface [polypeptide binding]; other site 266264013338 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 266264013339 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266264013340 active site 1 [active] 266264013341 dimer interface [polypeptide binding]; other site 266264013342 hexamer interface [polypeptide binding]; other site 266264013343 active site 2 [active] 266264013344 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 266264013345 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264013346 dimer interface [polypeptide binding]; other site 266264013347 putative CheW interface [polypeptide binding]; other site 266264013348 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266264013349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264013350 Helix-turn-helix domains; Region: HTH; cl00088 266264013351 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264013352 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 266264013353 putative active site [active] 266264013354 Zn binding site [ion binding]; other site 266264013355 Helix-turn-helix domains; Region: HTH; cl00088 266264013356 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 266264013357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264013358 dimerization interface [polypeptide binding]; other site 266264013359 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 266264013360 Phosphoesterase family; Region: Phosphoesterase; cl15450 266264013361 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266264013362 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266264013363 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 266264013364 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266264013365 dimer interface [polypeptide binding]; other site 266264013366 active site 266264013367 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264013368 substrate binding site [chemical binding]; other site 266264013369 catalytic residue [active] 266264013370 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 266264013371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264013372 dimerization interface [polypeptide binding]; other site 266264013373 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264013374 dimer interface [polypeptide binding]; other site 266264013375 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 266264013376 putative CheW interface [polypeptide binding]; other site 266264013377 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 266264013378 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 266264013379 putative catalytic residue [active] 266264013380 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266264013381 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 266264013382 putative NAD(P) binding site [chemical binding]; other site 266264013383 active site 266264013384 Helix-turn-helix domains; Region: HTH; cl00088 266264013385 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 266264013386 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 266264013387 FAD binding pocket [chemical binding]; other site 266264013388 FAD binding motif [chemical binding]; other site 266264013389 phosphate binding motif [ion binding]; other site 266264013390 NAD binding pocket [chemical binding]; other site 266264013391 aminotransferase; Validated; Region: PRK08175 266264013392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264013393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264013394 homodimer interface [polypeptide binding]; other site 266264013395 catalytic residue [active] 266264013396 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264013397 Helix-turn-helix domains; Region: HTH; cl00088 266264013398 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264013399 dimerization interface [polypeptide binding]; other site 266264013400 substrate binding pocket [chemical binding]; other site 266264013401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013402 NMT1-like family; Region: NMT1_2; cl15260 266264013403 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 266264013404 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 266264013405 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 266264013406 Helix-turn-helix domains; Region: HTH; cl00088 266264013407 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266264013408 putative dimerization interface [polypeptide binding]; other site 266264013409 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264013410 Helix-turn-helix domains; Region: HTH; cl00088 266264013411 Integrase core domain; Region: rve; cl01316 266264013412 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 266264013413 tricarballylate dehydrogenase; Validated; Region: PRK08274 266264013414 tricarballylate utilization protein B; Provisional; Region: PRK15033 266264013415 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266264013416 intersubunit interface [polypeptide binding]; other site 266264013417 active site 266264013418 Zn2+ binding site [ion binding]; other site 266264013419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013420 NMT1-like family; Region: NMT1_2; cl15260 266264013421 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266264013422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013423 Response regulator receiver domain; Region: Response_reg; pfam00072 266264013424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013425 active site 266264013426 phosphorylation site [posttranslational modification] 266264013427 intermolecular recognition site; other site 266264013428 dimerization interface [polypeptide binding]; other site 266264013429 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264013430 E3 interaction surface; other site 266264013431 lipoyl attachment site [posttranslational modification]; other site 266264013432 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 266264013433 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 266264013434 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264013435 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264013436 LysE type translocator; Region: LysE; cl00565 266264013437 Helix-turn-helix domains; Region: HTH; cl00088 266264013438 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013439 dimerization interface [polypeptide binding]; other site 266264013440 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264013441 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264013442 trimer interface [polypeptide binding]; other site 266264013443 eyelet of channel; other site 266264013444 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264013445 Helix-turn-helix domains; Region: HTH; cl00088 266264013446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013447 NMT1-like family; Region: NMT1_2; cl15260 266264013448 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264013449 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013450 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264013451 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264013452 substrate binding site [chemical binding]; other site 266264013453 oxyanion hole (OAH) forming residues; other site 266264013454 trimer interface [polypeptide binding]; other site 266264013455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013456 Helix-turn-helix domains; Region: HTH; cl00088 266264013457 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266264013458 putative dimerization interface [polypeptide binding]; other site 266264013459 Transposase domain (DUF772); Region: DUF772; pfam05598 266264013460 DDE superfamily endonuclease; Region: DDE_4; cl15789 266264013461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264013462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013463 active site 266264013464 phosphorylation site [posttranslational modification] 266264013465 intermolecular recognition site; other site 266264013466 dimerization interface [polypeptide binding]; other site 266264013467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264013468 DNA binding residues [nucleotide binding] 266264013469 dimerization interface [polypeptide binding]; other site 266264013470 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264013471 trimer interface [polypeptide binding]; other site 266264013472 eyelet of channel; other site 266264013473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013474 NMT1-like family; Region: NMT1_2; cl15260 266264013475 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 266264013476 hypothetical protein; Validated; Region: PRK06201 266264013477 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266264013478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013479 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264013480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013481 active site 266264013482 phosphorylation site [posttranslational modification] 266264013483 intermolecular recognition site; other site 266264013484 dimerization interface [polypeptide binding]; other site 266264013485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264013486 DNA binding residues [nucleotide binding] 266264013487 dimerization interface [polypeptide binding]; other site 266264013488 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264013489 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264013490 eyelet of channel; other site 266264013491 trimer interface [polypeptide binding]; other site 266264013492 aconitate hydratase; Validated; Region: PRK09277 266264013493 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266264013494 substrate binding site [chemical binding]; other site 266264013495 ligand binding site [chemical binding]; other site 266264013496 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 266264013497 substrate binding site [chemical binding]; other site 266264013498 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264013499 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264013500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013501 NMT1-like family; Region: NMT1_2; cl15260 266264013502 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264013503 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264013504 ligand binding site [chemical binding]; other site 266264013505 flexible hinge region; other site 266264013506 Helix-turn-helix domains; Region: HTH; cl00088 266264013507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013508 Helix-turn-helix domains; Region: HTH; cl00088 266264013509 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266264013510 putative dimerization interface [polypeptide binding]; other site 266264013511 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 266264013512 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 266264013513 Fimbrial protein; Region: Fimbrial; cl01416 266264013514 putative chaperone protein EcpD; Provisional; Region: PRK09926 266264013515 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266264013516 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266264013517 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266264013518 PapC N-terminal domain; Region: PapC_N; pfam13954 266264013519 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266264013520 PapC C-terminal domain; Region: PapC_C; pfam13953 266264013521 Fimbrial protein; Region: Fimbrial; cl01416 266264013522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264013523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264013524 dimer interface [polypeptide binding]; other site 266264013525 phosphorylation site [posttranslational modification] 266264013526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264013527 ATP binding site [chemical binding]; other site 266264013528 Mg2+ binding site [ion binding]; other site 266264013529 G-X-G motif; other site 266264013530 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264013531 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264013532 substrate binding pocket [chemical binding]; other site 266264013533 membrane-bound complex binding site; other site 266264013534 hinge residues; other site 266264013535 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264013536 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264013537 substrate binding pocket [chemical binding]; other site 266264013538 membrane-bound complex binding site; other site 266264013539 hinge residues; other site 266264013540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264013541 PAS domain; Region: PAS_9; pfam13426 266264013542 putative active site [active] 266264013543 heme pocket [chemical binding]; other site 266264013544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264013545 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 266264013546 dimer interface [polypeptide binding]; other site 266264013547 phosphorylation site [posttranslational modification] 266264013548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264013549 ATP binding site [chemical binding]; other site 266264013550 Mg2+ binding site [ion binding]; other site 266264013551 G-X-G motif; other site 266264013552 Response regulator receiver domain; Region: Response_reg; pfam00072 266264013553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013554 active site 266264013555 phosphorylation site [posttranslational modification] 266264013556 intermolecular recognition site; other site 266264013557 dimerization interface [polypeptide binding]; other site 266264013558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013560 voltage-gated potassium channel; Provisional; Region: PRK10537 266264013561 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 266264013562 Pirin-related protein [General function prediction only]; Region: COG1741 266264013563 Cupin domain; Region: Cupin_2; cl09118 266264013564 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266264013565 LysR family transcriptional regulator; Provisional; Region: PRK14997 266264013566 Helix-turn-helix domains; Region: HTH; cl00088 266264013567 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 266264013568 putative effector binding pocket; other site 266264013569 putative dimerization interface [polypeptide binding]; other site 266264013570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013571 Helix-turn-helix domains; Region: HTH; cl00088 266264013572 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264013573 putative effector binding pocket; other site 266264013574 dimerization interface [polypeptide binding]; other site 266264013575 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 266264013576 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 266264013577 dimer interface [polypeptide binding]; other site 266264013578 TPP-binding site [chemical binding]; other site 266264013579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264013580 Helix-turn-helix domains; Region: HTH; cl00088 266264013581 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 266264013582 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266264013583 Isochorismatase family; Region: Isochorismatase; pfam00857 266264013584 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264013585 catalytic triad [active] 266264013586 dimer interface [polypeptide binding]; other site 266264013587 conserved cis-peptide bond; other site 266264013588 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 266264013589 active site 266264013590 oxalacetate binding site [chemical binding]; other site 266264013591 citrylCoA binding site [chemical binding]; other site 266264013592 coenzyme A binding site [chemical binding]; other site 266264013593 catalytic triad [active] 266264013594 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266264013595 AMP-binding enzyme; Region: AMP-binding; cl15778 266264013596 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 266264013597 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 266264013598 active site 266264013599 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266264013600 Helix-turn-helix domains; Region: HTH; cl00088 266264013601 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264013602 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013603 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266264013604 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266264013605 substrate binding site [chemical binding]; other site 266264013606 ligand binding site [chemical binding]; other site 266264013607 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266264013608 substrate binding site [chemical binding]; other site 266264013609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013610 NMT1-like family; Region: NMT1_2; cl15260 266264013611 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 266264013612 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264013613 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264013614 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 266264013615 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264013616 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266264013617 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 266264013618 DoxX; Region: DoxX; cl00976 266264013619 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266264013620 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 266264013621 NAD(P) binding site [chemical binding]; other site 266264013622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013623 Helix-turn-helix domains; Region: HTH; cl00088 266264013624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013625 dimerization interface [polypeptide binding]; other site 266264013626 BON domain; Region: BON; cl02771 266264013627 Entericidin EcnA/B family; Region: Entericidin; cl02322 266264013628 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 266264013629 dimer interface [polypeptide binding]; other site 266264013630 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264013631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013632 NMT1-like family; Region: NMT1_2; cl15260 266264013633 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 266264013634 short chain dehydrogenase; Validated; Region: PRK06182 266264013635 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266264013636 NADP binding site [chemical binding]; other site 266264013637 active site 266264013638 steroid binding site; other site 266264013639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013640 NAD(P) binding site [chemical binding]; other site 266264013641 active site 266264013642 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264013643 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264013644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264013645 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 266264013646 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266264013647 tetramer interface [polypeptide binding]; other site 266264013648 active site 266264013649 Mg2+/Mn2+ binding site [ion binding]; other site 266264013650 Propionate catabolism activator; Region: PrpR_N; pfam06506 266264013651 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 266264013652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264013653 Walker A motif; other site 266264013654 ATP binding site [chemical binding]; other site 266264013655 Walker B motif; other site 266264013656 arginine finger; other site 266264013657 Helix-turn-helix domains; Region: HTH; cl00088 266264013658 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266264013659 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266264013660 putative NAD(P) binding site [chemical binding]; other site 266264013661 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264013662 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013663 Helix-turn-helix domains; Region: HTH; cl00088 266264013664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013665 dimerization interface [polypeptide binding]; other site 266264013666 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 266264013667 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266264013668 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266264013669 SLBB domain; Region: SLBB; pfam10531 266264013670 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 266264013671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013672 FAD binding domain; Region: FAD_binding_2; pfam00890 266264013673 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266264013674 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266264013675 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 266264013676 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266264013677 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266264013678 transmembrane helices; other site 266264013679 hypothetical protein 266264013680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013681 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266264013682 putative substrate translocation pore; other site 266264013683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264013684 Helix-turn-helix domains; Region: HTH; cl00088 266264013685 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 266264013686 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264013687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264013688 hypothetical protein 266264013689 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266264013690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264013691 oxidoreductase protein (fragment) 266264013692 Predicted transcriptional regulator [Transcription]; Region: COG1959 266264013693 Helix-turn-helix domains; Region: HTH; cl00088 266264013694 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264013695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013696 putative substrate translocation pore; other site 266264013697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013698 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 266264013699 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264013700 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264013701 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264013702 Cupin domain; Region: Cupin_2; cl09118 266264013703 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264013704 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264013705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264013706 DNA-binding site [nucleotide binding]; DNA binding site 266264013707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264013708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264013709 homodimer interface [polypeptide binding]; other site 266264013710 catalytic residue [active] 266264013711 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264013712 classical (c) SDRs; Region: SDR_c; cd05233 266264013713 NAD(P) binding site [chemical binding]; other site 266264013714 active site 266264013715 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 266264013716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264013717 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264013718 Helix-turn-helix domains; Region: HTH; cl00088 266264013719 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 266264013720 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 266264013721 Low-spin heme binding site [chemical binding]; other site 266264013722 Putative water exit pathway; other site 266264013723 Binuclear center (active site) [active] 266264013724 Putative proton exit pathway; other site 266264013725 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 266264013726 Cytochrome c; Region: Cytochrom_C; cl11414 266264013727 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266264013728 Cu(I) binding site [ion binding]; other site 266264013729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013730 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264013731 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264013732 Predicted transcriptional regulator [Transcription]; Region: COG1959 266264013733 Helix-turn-helix domains; Region: HTH; cl00088 266264013734 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266264013735 NMT1-like family; Region: NMT1_2; cl15260 266264013736 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264013737 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266264013738 Walker A/P-loop; other site 266264013739 ATP binding site [chemical binding]; other site 266264013740 Q-loop/lid; other site 266264013741 ABC transporter signature motif; other site 266264013742 Walker B; other site 266264013743 D-loop; other site 266264013744 H-loop/switch region; other site 266264013745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266264013746 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266264013747 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266264013748 active site 266264013749 Ferredoxin [Energy production and conversion]; Region: COG1146 266264013750 4Fe-4S binding domain; Region: Fer4; cl02805 266264013751 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 266264013752 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266264013753 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 266264013754 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266264013755 putative di-iron ligands [ion binding]; other site 266264013756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013757 NMT1-like family; Region: NMT1_2; cl15260 266264013758 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264013759 active site residue [active] 266264013760 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264013761 active site residue [active] 266264013762 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264013763 active site residue [active] 266264013764 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264013765 active site residue [active] 266264013766 histidine kinase 266264013767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013768 Predicted dehydrogenase [General function prediction only]; Region: COG0579 266264013769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013770 NMT1-like family; Region: NMT1_2; cl15260 266264013771 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266264013772 active sites [active] 266264013773 argininosuccinate lyase; Provisional; Region: PRK00855 266264013774 tetramer interface [polypeptide binding]; other site 266264013775 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266264013776 Helix-turn-helix domains; Region: HTH; cl00088 266264013777 The C-terminal substrate-domain of LysR-type transcriptional regulator, NocR, involved in the catabolism of nopaline, contains the type 2 periplasmic binding fold; Region: PBP2_NocR; cd08458 266264013778 putative dimerization interface [polypeptide binding]; other site 266264013779 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264013780 trimer interface [polypeptide binding]; other site 266264013781 eyelet of channel; other site 266264013782 conserved hypothetical protein 266264013783 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264013784 hypothetical protein 266264013785 hypothetical protein 266264013786 Protein with unknown function (DUF469); Region: DUF469; cl01237 266264013787 UvrD/REP helicase family protein 266264013788 hypothetical protein 266264013789 Domain of unknown function (DUF427); Region: DUF427; cl00998 266264013790 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264013791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264013792 DNA-binding site [nucleotide binding]; DNA binding site 266264013793 FCD domain; Region: FCD; cl11656 266264013794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264013795 PAS domain; Region: PAS_9; pfam13426 266264013796 putative active site [active] 266264013797 heme pocket [chemical binding]; other site 266264013798 Helix-turn-helix domains; Region: HTH; cl00088 266264013799 Integral membrane protein TerC family; Region: TerC; cl10468 266264013800 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 266264013801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013802 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266264013803 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264013804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264013805 DNA-binding site [nucleotide binding]; DNA binding site 266264013806 FCD domain; Region: FCD; cl11656 266264013807 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266264013808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013809 CoA-ligase; Region: Ligase_CoA; cl02894 266264013810 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 266264013811 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264013812 CoA-ligase; Region: Ligase_CoA; cl02894 266264013813 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 266264013814 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264013815 PYR/PP interface [polypeptide binding]; other site 266264013816 dimer interface [polypeptide binding]; other site 266264013817 TPP binding site [chemical binding]; other site 266264013818 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266264013819 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 266264013820 TPP-binding site; other site 266264013821 dimer interface [polypeptide binding]; other site 266264013822 formyl-coenzyme A transferase; Provisional; Region: PRK05398 266264013823 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013824 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264013825 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 266264013826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013827 CoA-ligase; Region: Ligase_CoA; cl02894 266264013828 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 266264013829 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264013830 Helix-turn-helix domains; Region: HTH; cl00088 266264013831 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 266264013832 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 266264013833 putative dimerization interface [polypeptide binding]; other site 266264013834 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 266264013835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013836 putative substrate translocation pore; other site 266264013837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013838 Helix-turn-helix domains; Region: HTH; cl00088 266264013839 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266264013840 putative dimerization interface [polypeptide binding]; other site 266264013841 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 266264013842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013843 putative substrate translocation pore; other site 266264013844 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 266264013845 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 266264013846 putative NAD(P) binding site [chemical binding]; other site 266264013847 dimer interface [polypeptide binding]; other site 266264013848 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264013849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264013850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264013851 Helix-turn-helix domains; Region: HTH; cl00088 266264013852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264013853 Cupin domain; Region: Cupin_2; cl09118 266264013854 fumarylacetoacetase; Region: PLN02856 266264013855 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 266264013856 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264013857 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 266264013858 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266264013859 putative acyl-acceptor binding pocket; other site 266264013860 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266264013861 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266264013862 Predicted membrane protein [Function unknown]; Region: COG4648 266264013863 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266264013864 AMP-binding enzyme; Region: AMP-binding; cl15778 266264013865 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264013866 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266264013867 Ligand binding site; other site 266264013868 Putative Catalytic site; other site 266264013869 DXD motif; other site 266264013870 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266264013871 putative acyl-acceptor binding pocket; other site 266264013872 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264013873 active site 266264013874 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 266264013875 Predicted exporter [General function prediction only]; Region: COG4258 266264013876 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266264013877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013878 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 266264013879 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 266264013880 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266264013881 dimer interface [polypeptide binding]; other site 266264013882 active site 266264013883 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 266264013884 putative active site 1 [active] 266264013885 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264013886 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266264013887 NAD(P) binding site [chemical binding]; other site 266264013888 homotetramer interface [polypeptide binding]; other site 266264013889 homodimer interface [polypeptide binding]; other site 266264013890 active site 266264013891 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 266264013892 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266264013893 dimer interface [polypeptide binding]; other site 266264013894 active site 266264013895 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 266264013896 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264013897 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264013898 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264013899 Ligand Binding Site [chemical binding]; other site 266264013900 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266264013901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013902 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266264013903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264013904 dimer interface [polypeptide binding]; other site 266264013905 conserved gate region; other site 266264013906 putative PBP binding loops; other site 266264013907 ABC-ATPase subunit interface; other site 266264013908 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 266264013909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264013910 dimer interface [polypeptide binding]; other site 266264013911 conserved gate region; other site 266264013912 putative PBP binding loops; other site 266264013913 ABC-ATPase subunit interface; other site 266264013914 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266264013915 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264013916 Walker A/P-loop; other site 266264013917 ATP binding site [chemical binding]; other site 266264013918 Q-loop/lid; other site 266264013919 ABC transporter signature motif; other site 266264013920 Walker B; other site 266264013921 D-loop; other site 266264013922 H-loop/switch region; other site 266264013923 TOBE domain; Region: TOBE_2; cl01440 266264013924 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 266264013925 EamA-like transporter family; Region: EamA; cl01037 266264013926 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266264013927 EamA-like transporter family; Region: EamA; cl01037 266264013928 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 266264013929 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 266264013930 Active site cavity [active] 266264013931 catalytic acid [active] 266264013932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264013933 Helix-turn-helix domains; Region: HTH; cl00088 266264013934 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 266264013935 conserved hypothetical protein (fragment) 266264013936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013937 NMT1-like family; Region: NMT1_2; cl15260 266264013938 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264013939 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264013940 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264013941 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264013942 active site 266264013943 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266264013944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013945 CoA-ligase; Region: Ligase_CoA; cl02894 266264013946 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264013947 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264013948 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264013949 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 266264013950 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264013951 active site 266264013952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013953 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264013954 NAD(P) binding site [chemical binding]; other site 266264013955 active site 266264013956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013957 NMT1-like family; Region: NMT1_2; cl15260 266264013958 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266264013959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264013960 DNA-binding site [nucleotide binding]; DNA binding site 266264013961 UTRA domain; Region: UTRA; cl01230 266264013962 extra-cytoplasmic solute receptor protein(fragment see also Rmet_4419 for the other fragment) 266264013963 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264013964 Helix-turn-helix domains; Region: HTH; cl00088 266264013965 Integrase core domain; Region: rve; cl01316 266264013966 extra-cytoplasmic solute receptor (Bug) 266264013967 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264013968 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013969 2-methylcitrate dehydratase (PrpD)family MmgE/PrpD family protein 266264013970 AAA domain; Region: AAA_22; pfam13401 266264013971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264013972 Walker A motif; other site 266264013973 ATP binding site [chemical binding]; other site 266264013974 Walker B motif; other site 266264013975 arginine finger; other site 266264013976 Integrase core domain; Region: rve; cl01316 266264013977 MmgE/PrpD family protein 266264013978 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264013979 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264013980 active site 266264013981 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266264013982 putative active site [active] 266264013983 putative catalytic site [active] 266264013984 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264013985 active site 2 [active] 266264013986 active site 1 [active] 266264013987 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266264013988 hypothetical protein 266264013989 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264013990 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266264013991 NAD(P) binding site [chemical binding]; other site 266264013992 catalytic residues [active] 266264013993 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266264013994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013995 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264013996 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264013997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013998 NMT1-like family; Region: NMT1_2; cl15260 266264013999 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 266264014000 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266264014001 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 266264014002 putative active site [active] 266264014003 catalytic triad [active] 266264014004 dimer interface [polypeptide binding]; other site 266264014005 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264014006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264014007 NMT1-like family; Region: NMT1_2; cl15260 266264014008 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 266264014009 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 266264014010 active site 266264014011 putative substrate binding pocket [chemical binding]; other site 266264014012 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264014013 homotrimer interaction site [polypeptide binding]; other site 266264014014 putative active site [active] 266264014015 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266264014016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264014017 Helix-turn-helix domains; Region: HTH; cl00088 266264014018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264014019 dimerization interface [polypeptide binding]; other site 266264014020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264014021 NMT1-like family; Region: NMT1_2; cl15260 266264014022 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266264014023 Helix-turn-helix domains; Region: HTH; cl00088 266264014024 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 266264014025 putative dimerization interface [polypeptide binding]; other site 266264014026 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264014027 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264014028 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264014029 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264014030 DNA-binding site [nucleotide binding]; DNA binding site 266264014031 FCD domain; Region: FCD; cl11656 266264014032 enoyl-CoA hydratase; Provisional; Region: PRK06127 266264014033 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264014034 substrate binding site [chemical binding]; other site 266264014035 oxyanion hole (OAH) forming residues; other site 266264014036 trimer interface [polypeptide binding]; other site 266264014037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264014038 NMT1-like family; Region: NMT1_2; cl15260 266264014039 conserved hypothetical protein; exported protein 266264014040 transcription regulator protein (fragment) 266264014041 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014042 Ligand Binding Site [chemical binding]; other site 266264014043 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264014044 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266264014045 conserved hypothetical protein; exported protein 266264014046 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 266264014047 AMP-binding enzyme; Region: AMP-binding; cl15778 266264014048 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264014049 Putative cyclase; Region: Cyclase; cl00814 266264014050 Cupin domain; Region: Cupin_2; cl09118 266264014051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264014052 NMT1-like family; Region: NMT1_2; cl15260 266264014053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264014054 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264014055 active site 266264014056 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266264014057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264014058 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 266264014059 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266264014060 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266264014061 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264014062 metal binding site [ion binding]; metal-binding site 266264014063 active site 266264014064 I-site; other site 266264014065 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264014066 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 266264014067 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 266264014068 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264014069 Helix-turn-helix domains; Region: HTH; cl00088 266264014070 Integrase core domain; Region: rve; cl01316 266264014071 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266264014072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264014073 active site 266264014074 phosphorylation site [posttranslational modification] 266264014075 intermolecular recognition site; other site 266264014076 dimerization interface [polypeptide binding]; other site 266264014077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264014078 DNA binding site [nucleotide binding] 266264014079 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264014080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264014081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264014082 dimer interface [polypeptide binding]; other site 266264014083 phosphorylation site [posttranslational modification] 266264014084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264014085 ATP binding site [chemical binding]; other site 266264014086 Mg2+ binding site [ion binding]; other site 266264014087 G-X-G motif; other site 266264014088 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266264014089 dimer interface [polypeptide binding]; other site 266264014090 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 266264014091 heavy metal cation tricomponent efflux, membrane fusion protein CzcB2(CzcB-like) 266264014092 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266264014093 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266264014094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014095 Ligand Binding Site [chemical binding]; other site 266264014096 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264014097 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264014098 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264014099 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264014100 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264014101 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264014102 catalytic residues [active] 266264014103 catalytic nucleophile [active] 266264014104 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264014105 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264014106 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264014107 Synaptic Site I dimer interface [polypeptide binding]; other site 266264014108 DNA binding site [nucleotide binding] 266264014109 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264014110 DNA-binding interface [nucleotide binding]; DNA binding site 266264014111 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264014112 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264014113 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264014114 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 266264014115 putative ligand binding site [chemical binding]; other site 266264014116 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264014117 TM-ABC transporter signature motif; other site 266264014118 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264014119 TM-ABC transporter signature motif; other site 266264014120 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264014121 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264014122 Walker A/P-loop; other site 266264014123 ATP binding site [chemical binding]; other site 266264014124 Q-loop/lid; other site 266264014125 ABC transporter signature motif; other site 266264014126 Walker B; other site 266264014127 D-loop; other site 266264014128 H-loop/switch region; other site 266264014129 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264014130 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264014131 Walker A/P-loop; other site 266264014132 ATP binding site [chemical binding]; other site 266264014133 Q-loop/lid; other site 266264014134 ABC transporter signature motif; other site 266264014135 Walker B; other site 266264014136 D-loop; other site 266264014137 H-loop/switch region; other site 266264014138 allantoate amidohydrolase; Reviewed; Region: PRK12893 266264014139 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266264014140 active site 266264014141 metal binding site [ion binding]; metal-binding site 266264014142 dimer interface [polypeptide binding]; other site 266264014143 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266264014144 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266264014145 MlrC C-terminus; Region: MlrC_C; pfam07171 266264014146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014147 Helix-turn-helix domains; Region: HTH; cl00088 266264014148 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264014149 CoenzymeA binding site [chemical binding]; other site 266264014150 subunit interaction site [polypeptide binding]; other site 266264014151 PHB binding site; other site 266264014152 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266264014153 Protein of unknown function (DUF342); Region: DUF342; pfam03961 266264014154 hypothetical protein 266264014155 conserved hypothetical protein (fragment) 266264014156 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264014157 hypothetical protein 266264014158 phage function unknown 266264014159 conserved hypothetical protein (phage protein) 266264014160 phage major tail protein (fragment?) 266264014161 transposase (fragment) 266264014162 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264014163 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264014164 N-terminal plug; other site 266264014165 ligand-binding site [chemical binding]; other site 266264014166 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264014167 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264014168 N-terminal plug; other site 266264014169 ligand-binding site [chemical binding]; other site 266264014170 fec operon regulator FecR; Reviewed; Region: PRK09774 266264014171 FecR protein; Region: FecR; pfam04773 266264014172 RNA polymerase sigma factor; Provisional; Region: PRK12528 266264014173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264014174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264014175 DNA binding residues [nucleotide binding] 266264014176 hypothetical protein 266264014177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264014178 NMT1-like family; Region: NMT1_2; cl15260 266264014179 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 266264014180 AMP-binding enzyme; Region: AMP-binding; cl15778 266264014181 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264014182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264014183 NMT1-like family; Region: NMT1_2; cl15260 266264014184 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264014185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264014186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014187 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 266264014188 Helix-turn-helix domains; Region: HTH; cl00088 266264014189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264014190 citrate-proton symporter; Provisional; Region: PRK15075 266264014191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014192 putative substrate translocation pore; other site 266264014193 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266264014194 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266264014195 metal binding site [ion binding]; metal-binding site 266264014196 putative dimer interface [polypeptide binding]; other site 266264014197 Flagellar protein YcgR; Region: YcgR_2; pfam12945 266264014198 PilZ domain; Region: PilZ; cl01260 266264014199 multidrug resistance protein MdtN; Provisional; Region: PRK10476 266264014200 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264014201 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264014202 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266264014203 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 266264014204 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264014205 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264014206 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264014207 active site 2 [active] 266264014208 active site 1 [active] 266264014209 Phage integrase protein; Region: DUF3701; pfam12482 266264014210 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266264014211 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 266264014212 Int/Topo IB signature motif; other site 266264014213 PAS domain S-box; Region: sensory_box; TIGR00229 266264014214 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264014215 putative active site [active] 266264014216 heme pocket [chemical binding]; other site 266264014217 Histidine kinase; Region: HisKA_3; pfam07730 266264014218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264014219 ATP binding site [chemical binding]; other site 266264014220 Mg2+ binding site [ion binding]; other site 266264014221 G-X-G motif; other site 266264014222 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264014223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264014224 active site 266264014225 phosphorylation site [posttranslational modification] 266264014226 intermolecular recognition site; other site 266264014227 dimerization interface [polypeptide binding]; other site 266264014228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264014229 DNA binding residues [nucleotide binding] 266264014230 dimerization interface [polypeptide binding]; other site 266264014231 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014232 Ligand Binding Site [chemical binding]; other site 266264014233 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266264014234 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014235 Ligand Binding Site [chemical binding]; other site 266264014236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 266264014237 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264014238 Beta-Casp domain; Region: Beta-Casp; cl12567 266264014239 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266264014240 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014241 Ligand Binding Site [chemical binding]; other site 266264014242 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 266264014243 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264014244 ligand binding site [chemical binding]; other site 266264014245 flexible hinge region; other site 266264014246 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264014247 putative switch regulator; other site 266264014248 non-specific DNA interactions [nucleotide binding]; other site 266264014249 DNA binding site [nucleotide binding] 266264014250 sequence specific DNA binding site [nucleotide binding]; other site 266264014251 putative cAMP binding site [chemical binding]; other site 266264014252 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266264014253 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266264014254 conserved cys residue [active] 266264014255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014256 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266264014257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264014258 NAD(P) binding site [chemical binding]; other site 266264014259 active site 266264014260 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266264014261 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 266264014262 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266264014263 MoxR-like ATPases [General function prediction only]; Region: COG0714 266264014264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264014265 spermidine synthase; Provisional; Region: PRK03612 266264014266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264014267 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266264014268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264014269 motif II; other site 266264014270 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 266264014271 Oxygen tolerance; Region: BatD; pfam13584 266264014272 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266264014273 metal ion-dependent adhesion site (MIDAS); other site 266264014274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264014275 TPR motif; other site 266264014276 binding surface 266264014277 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266264014278 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 266264014279 metal ion-dependent adhesion site (MIDAS); other site 266264014280 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 266264014281 tyrosine-based site-specific recombinase activity (fragment) 266264014282 tyrosine-based site-specific recombinase activity (fragment) 266264014283 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 266264014284 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 266264014285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264014286 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 266264014287 L-serine binding site [chemical binding]; other site 266264014288 ACT domain interface; other site 266264014289 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 266264014290 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 266264014291 DNA binding residues [nucleotide binding] 266264014292 dimer interface [polypeptide binding]; other site 266264014293 [2Fe-2S] cluster binding site [ion binding]; other site 266264014294 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264014295 homotrimer interaction site [polypeptide binding]; other site 266264014296 putative active site [active] 266264014297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264014299 putative substrate translocation pore; other site 266264014300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014301 transcriptional regulator; Provisional; Region: PRK10632 266264014302 Helix-turn-helix domains; Region: HTH; cl00088 266264014303 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266264014304 putative effector binding pocket; other site 266264014305 putative dimerization interface [polypeptide binding]; other site 266264014306 short chain dehydrogenase; Provisional; Region: PRK12937 266264014307 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 266264014308 NADP binding site [chemical binding]; other site 266264014309 homodimer interface [polypeptide binding]; other site 266264014310 active site 266264014311 substrate binding site [chemical binding]; other site 266264014312 Helix-turn-helix domains; Region: HTH; cl00088 266264014313 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264014314 trimer interface [polypeptide binding]; other site 266264014315 eyelet of channel; other site 266264014316 Helix-turn-helix domains; Region: HTH; cl00088 266264014317 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 266264014318 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 266264014319 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 266264014320 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 266264014321 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 266264014322 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264014323 Walker A/P-loop; other site 266264014324 ATP binding site [chemical binding]; other site 266264014325 Q-loop/lid; other site 266264014326 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 266264014327 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 266264014328 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 266264014329 conserved hypothetical protein (fragment?) 266264014330 conserved hypothetical protein (fragment?) 266264014331 hypothetical protein; exported protein 266264014332 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 266264014333 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 266264014334 dimerization interface [polypeptide binding]; other site 266264014335 mannose binding site [chemical binding]; other site 266264014336 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 266264014337 mannose binding site [chemical binding]; other site 266264014338 transposase IS3/IS911 family (fragment) 266264014339 hypothetical protein 266264014340 transposase catalytic domain family IS3/IS911 (fragment) 266264014341 catalytic domain:Transposase IS3/IS911 (fragment) 266264014342 Tyr recombinase activity site-specific recombination (fragment) 266264014343 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 266264014344 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 266264014345 putative uracil binding site [chemical binding]; other site 266264014346 putative active site [active] 266264014347 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 266264014348 Helix-turn-helix domains; Region: HTH; cl00088 266264014349 AsnC family; Region: AsnC_trans_reg; pfam01037 266264014350 EamA-like transporter family; Region: EamA; cl01037 266264014351 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266264014352 Helix-turn-helix domains; Region: HTH; cl00088 266264014353 AsnC family; Region: AsnC_trans_reg; pfam01037 266264014354 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 266264014355 Helix-turn-helix domains; Region: HTH; cl00088 266264014356 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 266264014357 putative dimerization interface [polypeptide binding]; other site 266264014358 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 266264014359 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 266264014360 THF binding site; other site 266264014361 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266264014362 substrate binding site [chemical binding]; other site 266264014363 THF binding site; other site 266264014364 zinc-binding site [ion binding]; other site 266264014365 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264014366 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264014367 N-terminal plug; other site 266264014368 ligand-binding site [chemical binding]; other site 266264014369 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264014370 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266264014371 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264014372 cytosine deaminase; Validated; Region: PRK07572 266264014373 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266264014374 active site 266264014375 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266264014376 Helix-turn-helix domains; Region: HTH; cl00088 266264014377 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 266264014378 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264014379 active site 266264014380 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 266264014381 hypothetical protein; Validated; Region: PRK07198 266264014382 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 266264014383 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 266264014384 dimerization interface [polypeptide binding]; other site 266264014385 active site 266264014386 OpgC protein; Region: OpgC_C; cl00792 266264014387 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264014388 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264014389 active site 266264014390 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266264014391 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264014392 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264014393 active site 266264014394 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266264014395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264014396 dimer interface [polypeptide binding]; other site 266264014397 conserved gate region; other site 266264014398 putative PBP binding loops; other site 266264014399 ABC-ATPase subunit interface; other site 266264014400 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266264014401 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266264014402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264014403 dimer interface [polypeptide binding]; other site 266264014404 conserved gate region; other site 266264014405 putative PBP binding loops; other site 266264014406 ABC-ATPase subunit interface; other site 266264014407 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266264014408 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266264014409 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266264014410 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264014411 Walker A/P-loop; other site 266264014412 ATP binding site [chemical binding]; other site 266264014413 Q-loop/lid; other site 266264014414 ABC transporter signature motif; other site 266264014415 Walker B; other site 266264014416 D-loop; other site 266264014417 H-loop/switch region; other site 266264014418 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264014419 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 266264014420 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264014421 Walker A/P-loop; other site 266264014422 ATP binding site [chemical binding]; other site 266264014423 Q-loop/lid; other site 266264014424 ABC transporter signature motif; other site 266264014425 Walker B; other site 266264014426 D-loop; other site 266264014427 H-loop/switch region; other site 266264014428 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264014429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014430 Helix-turn-helix domains; Region: HTH; cl00088 266264014431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014432 Helix-turn-helix domains; Region: HTH; cl00088 266264014433 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264014434 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266264014435 substrate binding site [chemical binding]; other site 266264014436 oxyanion hole (OAH) forming residues; other site 266264014437 trimer interface [polypeptide binding]; other site 266264014438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264014439 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264014440 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264014441 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264014442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264014443 substrate binding pocket [chemical binding]; other site 266264014444 membrane-bound complex binding site; other site 266264014445 hinge residues; other site 266264014446 Dehydratase family; Region: ILVD_EDD; cl00340 266264014447 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266264014448 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 266264014449 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 266264014450 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266264014451 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266264014452 inhibitor-cofactor binding pocket; inhibition site 266264014453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264014454 catalytic residue [active] 266264014455 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266264014456 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266264014457 Ligand binding site; other site 266264014458 Putative Catalytic site; other site 266264014459 DXD motif; other site 266264014460 putative formyltransferase; Provisional; Region: PRK06988 266264014461 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 266264014462 active site 266264014463 substrate binding site [chemical binding]; other site 266264014464 cosubstrate binding site; other site 266264014465 catalytic site [active] 266264014466 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 266264014467 active site 266264014468 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 266264014469 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 266264014470 NAD binding site [chemical binding]; other site 266264014471 substrate binding site [chemical binding]; other site 266264014472 active site 266264014473 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 266264014474 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 266264014475 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264014476 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 266264014477 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264014478 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264014479 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264014480 heavy metal cation tricomponent efflux, membrane fusion protein (CzcB-like) 266264014481 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264014482 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264014483 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264014484 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264014485 catalytic residues [active] 266264014486 catalytic nucleophile [active] 266264014487 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264014488 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264014489 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264014490 Synaptic Site I dimer interface [polypeptide binding]; other site 266264014491 DNA binding site [nucleotide binding] 266264014492 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264014493 DNA-binding interface [nucleotide binding]; DNA binding site 266264014494 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264014495 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264014496 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264014497 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264014498 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266264014499 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014500 Ligand Binding Site [chemical binding]; other site 266264014501 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266264014502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264014503 DNA-binding site [nucleotide binding]; DNA binding site 266264014504 FCD domain; Region: FCD; cl11656 266264014505 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264014506 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264014507 substrate binding pocket [chemical binding]; other site 266264014508 membrane-bound complex binding site; other site 266264014509 hinge residues; other site 266264014510 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264014511 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264014512 substrate binding pocket [chemical binding]; other site 266264014513 membrane-bound complex binding site; other site 266264014514 hinge residues; other site 266264014515 PAS fold; Region: PAS_4; pfam08448 266264014516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264014517 putative active site [active] 266264014518 heme pocket [chemical binding]; other site 266264014519 PAS fold; Region: PAS_3; pfam08447 266264014520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264014521 dimer interface [polypeptide binding]; other site 266264014522 phosphorylation site [posttranslational modification] 266264014523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264014524 ATP binding site [chemical binding]; other site 266264014525 Mg2+ binding site [ion binding]; other site 266264014526 G-X-G motif; other site 266264014527 Response regulator receiver domain; Region: Response_reg; pfam00072 266264014528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264014529 active site 266264014530 phosphorylation site [posttranslational modification] 266264014531 intermolecular recognition site; other site 266264014532 dimerization interface [polypeptide binding]; other site 266264014533 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 266264014534 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266264014535 homodimer interface [polypeptide binding]; other site 266264014536 substrate-cofactor binding pocket; other site 266264014537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264014538 catalytic residue [active] 266264014539 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264014540 N-terminal plug; other site 266264014541 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 266264014542 ligand-binding site [chemical binding]; other site 266264014543 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 266264014544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264014545 NMT1-like family; Region: NMT1_2; cl15260 266264014546 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 266264014547 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264014548 Helix-turn-helix domains; Region: HTH; cl00088 266264014549 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264014550 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264014551 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266264014552 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264014553 active site 266264014554 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264014555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264014556 NAD(P) binding site [chemical binding]; other site 266264014557 active site 266264014558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264014559 DNA-binding site [nucleotide binding]; DNA binding site 266264014560 FCD domain; Region: FCD; cl11656 266264014561 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 266264014562 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 266264014563 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264014564 N-terminal plug; other site 266264014565 ligand-binding site [chemical binding]; other site 266264014566 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264014567 multidrug resistance protein MdtN; Provisional; Region: PRK10476 266264014568 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264014569 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264014570 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 266264014571 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 266264014572 Phosphoesterase family; Region: Phosphoesterase; cl15450 266264014573 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266264014574 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266264014575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264014576 phosphorylation site [posttranslational modification] 266264014577 dimer interface [polypeptide binding]; other site 266264014578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264014579 ATP binding site [chemical binding]; other site 266264014580 Mg2+ binding site [ion binding]; other site 266264014581 G-X-G motif; other site 266264014582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264014583 active site 266264014584 phosphorylation site [posttranslational modification] 266264014585 intermolecular recognition site; other site 266264014586 dimerization interface [polypeptide binding]; other site 266264014587 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 266264014588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264014589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264014590 active site 266264014591 phosphorylation site [posttranslational modification] 266264014592 intermolecular recognition site; other site 266264014593 dimerization interface [polypeptide binding]; other site 266264014594 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264014595 DNA binding residues [nucleotide binding] 266264014596 dimerization interface [polypeptide binding]; other site 266264014597 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266264014598 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266264014599 NADP binding site [chemical binding]; other site 266264014600 dimer interface [polypeptide binding]; other site 266264014601 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264014602 Helix-turn-helix domains; Region: HTH; cl00088 266264014603 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264014604 DNA-binding interface [nucleotide binding]; DNA binding site 266264014605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264014607 NMT1-like family; Region: NMT1_2; cl15260 266264014608 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266264014609 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264014610 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264014611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014612 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264014613 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264014614 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 266264014615 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 266264014616 active site 266264014617 substrate binding site [chemical binding]; other site 266264014618 Mg2+ binding site [ion binding]; other site 266264014619 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264014620 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264014621 Sulfate transporter family; Region: Sulfate_transp; cl15842 266264014622 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264014623 Cytochrome c; Region: Cytochrom_C; cl11414 266264014624 Ubiquitin-like proteins; Region: UBQ; cl00155 266264014625 VPS10 domain; Region: VPS10; smart00602 266264014626 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266264014627 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264014628 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264014629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264014630 Walker A/P-loop; other site 266264014631 Walker A/P-loop; other site 266264014632 ATP binding site [chemical binding]; other site 266264014633 ATP binding site [chemical binding]; other site 266264014634 Q-loop/lid; other site 266264014635 ABC transporter signature motif; other site 266264014636 Walker B; other site 266264014637 D-loop; other site 266264014638 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 266264014639 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 266264014640 putative active site [active] 266264014641 putative metal-binding site [ion binding]; other site 266264014642 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 266264014643 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266264014644 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264014645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264014646 NMT1-like family; Region: NMT1_2; cl15260 266264014647 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264014648 classical (c) SDRs; Region: SDR_c; cd05233 266264014649 NAD(P) binding site [chemical binding]; other site 266264014650 active site 266264014651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266264014652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266264014653 DNA binding site [nucleotide binding] 266264014654 domain linker motif; other site 266264014655 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 266264014656 putative dimerization interface [polypeptide binding]; other site 266264014657 putative ligand binding site [chemical binding]; other site 266264014658 Fic family protein [Function unknown]; Region: COG3177 266264014659 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 266264014660 Fic/DOC family; Region: Fic; cl00960 266264014661 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264014662 Helix-turn-helix domains; Region: HTH; cl00088 266264014663 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 266264014664 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264014665 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264014666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264014668 putative substrate translocation pore; other site 266264014669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014670 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266264014671 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266264014672 active site 266264014673 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266264014674 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 266264014675 active sites [active] 266264014676 tetramer interface [polypeptide binding]; other site 266264014677 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266264014678 diguanylate cyclase/phosphodiesterase; PAS, GGDEF and EAL domains 266264014679 Helix-turn-helix domains; Region: HTH; cl00088 266264014680 putative transposase OrfB; Reviewed; Region: PHA02517 266264014681 HTH-like domain; Region: HTH_21; pfam13276 266264014682 Integrase core domain; Region: rve; cl01316 266264014683 Integrase core domain; Region: rve_3; cl15866 266264014684 diguanylate cyclase/phosphodiesterase; PAS, GGDEF and EAL domains 266264014685 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266264014686 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266264014687 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266264014688 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266264014689 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264014690 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266264014691 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264014692 DNA binding residues [nucleotide binding] 266264014693 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 266264014694 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 266264014695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264014696 S-adenosylmethionine binding site [chemical binding]; other site 266264014697 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266264014698 dimerization domain swap beta strand [polypeptide binding]; other site 266264014699 regulatory protein interface [polypeptide binding]; other site 266264014700 active site 266264014701 regulatory phosphorylation site [posttranslational modification]; other site 266264014702 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 266264014703 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 266264014704 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 266264014705 hydrogenase 4 subunit F; Validated; Region: PRK06458 266264014706 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 266264014707 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 266264014708 NADH dehydrogenase; Region: NADHdh; cl00469 266264014709 hydrogenase 4 subunit B; Validated; Region: PRK06521 266264014710 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 266264014711 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 266264014712 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266264014713 putative active site [active] 266264014714 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266264014715 Muconolactone delta-isomerase; Region: MIase; cl01992 266264014716 Putative cyclase; Region: Cyclase; cl00814 266264014717 YCII-related domain; Region: YCII; cl00999 266264014718 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 266264014719 DoxX; Region: DoxX; cl00976 266264014720 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 266264014721 Protein of unknown function (DUF692); Region: DUF692; cl01263 266264014722 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 266264014723 RNA polymerase sigma factor; Provisional; Region: PRK12536 266264014724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264014725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264014726 DNA binding residues [nucleotide binding] 266264014727 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 266264014728 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264014729 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266264014730 active site 266264014731 nucleophile elbow; other site 266264014732 Citrate transporter; Region: CitMHS; pfam03600 266264014733 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 266264014734 Intracellular septation protein A; Region: IspA; cl01098 266264014735 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266264014736 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264014737 catalytic residue [active] 266264014738 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 266264014739 PPIC-type PPIASE domain; Region: Rotamase; cl08278 266264014740 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 266264014741 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266264014742 Cu(I) binding site [ion binding]; other site 266264014743 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 266264014744 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266264014745 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264014746 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266264014747 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264014748 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 266264014749 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266264014750 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 266264014751 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266264014752 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 266264014753 Secretin and TonB N terminus short domain; Region: STN; cl06624 266264014754 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266264014755 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264014756 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 266264014757 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 266264014758 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266264014759 Walker A motif; other site 266264014760 ATP binding site [chemical binding]; other site 266264014761 Walker B motif; other site 266264014762 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266264014763 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264014764 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266264014765 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 266264014766 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 266264014767 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266264014768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264014769 PAS domain; Region: PAS_9; pfam13426 266264014770 putative active site [active] 266264014771 heme pocket [chemical binding]; other site 266264014772 Histidine kinase; Region: HisKA_3; pfam07730 266264014773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264014774 ATP binding site [chemical binding]; other site 266264014775 Mg2+ binding site [ion binding]; other site 266264014776 G-X-G motif; other site 266264014777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264014778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264014779 active site 266264014780 phosphorylation site [posttranslational modification] 266264014781 intermolecular recognition site; other site 266264014782 dimerization interface [polypeptide binding]; other site 266264014783 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264014784 DNA binding residues [nucleotide binding] 266264014785 dimerization interface [polypeptide binding]; other site 266264014786 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 266264014787 Cupin domain; Region: Cupin_2; cl09118 266264014788 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264014789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014790 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264014791 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 266264014792 Helix-turn-helix domains; Region: HTH; cl00088 266264014793 WHG domain; Region: WHG; pfam13305 266264014794 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 266264014795 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 266264014796 putative active site [active] 266264014797 catalytic site [active] 266264014798 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 266264014799 putative active site [active] 266264014800 catalytic site [active] 266264014801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264014802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264014803 active site 266264014804 phosphorylation site [posttranslational modification] 266264014805 intermolecular recognition site; other site 266264014806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264014807 DNA binding site [nucleotide binding] 266264014808 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264014809 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 266264014810 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264014811 metal binding site [ion binding]; metal-binding site 266264014812 active site 266264014813 I-site; other site 266264014814 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264014815 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264014816 dimer interface [polypeptide binding]; other site 266264014817 putative CheW interface [polypeptide binding]; other site 266264014818 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266264014819 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264014820 Cupin domain; Region: Cupin_2; cl09118 266264014821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264014823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014824 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264014825 Helix-turn-helix domains; Region: HTH; cl00088 266264014826 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264014827 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 266264014828 putative substrate binding pocket [chemical binding]; other site 266264014829 trimer interface [polypeptide binding]; other site 266264014830 galactarate dehydratase; Region: galactar-dH20; TIGR03248 266264014831 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 266264014832 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266264014833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014834 D-galactonate transporter; Region: 2A0114; TIGR00893 266264014835 putative substrate translocation pore; other site 266264014836 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 266264014837 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266264014838 putative active site [active] 266264014839 catalytic residue [active] 266264014840 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266264014841 tetramer interface [polypeptide binding]; other site 266264014842 active site 266264014843 Mg2+/Mn2+ binding site [ion binding]; other site 266264014844 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 266264014845 Cupin domain; Region: Cupin_2; cl09118 266264014846 Phospholipid methyltransferase; Region: PEMT; cl00763 266264014847 Predicted acetyltransferase [General function prediction only]; Region: COG3153 266264014848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264014849 Coenzyme A binding pocket [chemical binding]; other site 266264014850 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 266264014851 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 266264014852 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264014853 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 266264014854 IHF dimer interface [polypeptide binding]; other site 266264014855 IHF - DNA interface [nucleotide binding]; other site 266264014856 Protein of unknown function (DUF962); Region: DUF962; cl01879 266264014857 N-acetyltransferase; Region: Acetyltransf_2; cl00949 266264014858 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266264014859 classical (c) SDRs; Region: SDR_c; cd05233 266264014860 NAD(P) binding site [chemical binding]; other site 266264014861 active site 266264014862 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264014863 AMP-binding enzyme; Region: AMP-binding; cl15778 266264014864 AMP-binding enzyme; Region: AMP-binding; cl15778 266264014865 CreA protein; Region: CreA; pfam05981 266264014866 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 266264014867 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266264014868 IHF dimer interface [polypeptide binding]; other site 266264014869 IHF - DNA interface [nucleotide binding]; other site 266264014870 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 266264014871 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264014872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014873 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 266264014874 putative substrate translocation pore; other site 266264014875 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 266264014876 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 266264014877 Ligand binding site; other site 266264014878 DXD motif; other site 266264014879 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 266264014880 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 266264014881 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 266264014882 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 266264014883 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 266264014884 FMN riboswitch 266264014885 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 266264014886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264014887 non-specific DNA binding site [nucleotide binding]; other site 266264014888 salt bridge; other site 266264014889 sequence-specific DNA binding site [nucleotide binding]; other site 266264014890 Protein of unknown function (DUF465); Region: DUF465; cl01070 266264014891 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 266264014892 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264014893 active site 266264014894 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 266264014895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264014896 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266264014897 Domain of unknown function DUF21; Region: DUF21; pfam01595 266264014898 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266264014899 Transporter associated domain; Region: CorC_HlyC; cl08393 266264014900 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 266264014901 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264014902 Entericidin EcnA/B family; Region: Entericidin; cl02322 266264014903 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 266264014904 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266264014905 active site 266264014906 intersubunit interface [polypeptide binding]; other site 266264014907 catalytic residue [active] 266264014908 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266264014909 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266264014910 substrate binding site [chemical binding]; other site 266264014911 ATP binding site [chemical binding]; other site 266264014912 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266264014913 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 266264014914 dimer interface [polypeptide binding]; other site 266264014915 active site 266264014916 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264014917 substrate binding site [chemical binding]; other site 266264014918 catalytic residue [active] 266264014919 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266264014920 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266264014921 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266264014922 putative active site [active] 266264014923 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 266264014924 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 266264014925 active site 266264014926 putative substrate binding pocket [chemical binding]; other site 266264014927 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264014928 homotrimer interaction site [polypeptide binding]; other site 266264014929 putative active site [active] 266264014930 GntP family permease; Region: GntP_permease; pfam02447 266264014931 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 266264014932 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264014933 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266264014934 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264014935 hypothetical protein 266264014936 hypothetical protein 266264014937 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264014938 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266264014939 Walker A/P-loop; other site 266264014940 ATP binding site [chemical binding]; other site 266264014941 Q-loop/lid; other site 266264014942 ABC transporter signature motif; other site 266264014943 Walker B; other site 266264014944 D-loop; other site 266264014945 H-loop/switch region; other site 266264014946 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264014947 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266264014948 Walker A/P-loop; other site 266264014949 ATP binding site [chemical binding]; other site 266264014950 Q-loop/lid; other site 266264014951 ABC transporter signature motif; other site 266264014952 Walker B; other site 266264014953 D-loop; other site 266264014954 H-loop/switch region; other site 266264014955 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264014956 TM-ABC transporter signature motif; other site 266264014957 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264014958 TM-ABC transporter signature motif; other site 266264014959 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264014960 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264014961 active site 266264014962 catalytic tetrad [active] 266264014963 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 266264014964 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 266264014965 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 266264014966 substrate binding site [chemical binding]; other site 266264014967 catalytic Zn binding site [ion binding]; other site 266264014968 NAD binding site [chemical binding]; other site 266264014969 structural Zn binding site [ion binding]; other site 266264014970 dimer interface [polypeptide binding]; other site 266264014971 Predicted esterase [General function prediction only]; Region: COG0627 266264014972 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264014973 Excalibur calcium-binding domain; Region: Excalibur; cl05460 266264014974 amidase; Provisional; Region: PRK07486 266264014975 Amidase; Region: Amidase; cl11426 266264014976 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264014977 NMT1-like family; Region: NMT1_2; cl15260 266264014978 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264014979 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 266264014980 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264014981 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264014982 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 266264014983 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266264014984 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 266264014985 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264014986 Helix-turn-helix domains; Region: HTH; cl00088 266264014987 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266264014988 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 266264014989 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 266264014990 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266264014991 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 266264014992 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 266264014993 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266264014994 RHS Repeat; Region: RHS_repeat; cl11982 266264014995 RHS Repeat; Region: RHS_repeat; cl11982 266264014996 RHS Repeat; Region: RHS_repeat; cl11982 266264014997 RHS Repeat; Region: RHS_repeat; cl11982 266264014998 RHS Repeat; Region: RHS_repeat; cl11982 266264014999 RHS Repeat; Region: RHS_repeat; cl11982 266264015000 RHS Repeat; Region: RHS_repeat; cl11982 266264015001 RHS Repeat; Region: RHS_repeat; cl11982 266264015002 RHS Repeat; Region: RHS_repeat; cl11982 266264015003 RHS protein; Region: RHS; pfam03527 266264015004 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 266264015005 hypothetical protein 266264015006 RHS family protein (fragment) 266264015007 PAAR motif; Region: PAAR_motif; cl15808 266264015008 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266264015009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264015010 NAD(P) binding site [chemical binding]; other site 266264015011 active site 266264015012 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 266264015013 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266264015014 substrate-cofactor binding pocket; other site 266264015015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264015016 catalytic residue [active] 266264015017 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264015018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264015019 sequence-specific DNA binding site [nucleotide binding]; other site 266264015020 salt bridge; other site 266264015021 Cupin domain; Region: Cupin_2; cl09118 266264015022 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 266264015023 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 266264015024 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 266264015025 Phosphoesterase family; Region: Phosphoesterase; cl15450 266264015026 benzoate transport; Region: 2A0115; TIGR00895 266264015027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015029 hypothetical protein 266264015030 hypothetical protein 266264015031 hypothetical protein 266264015032 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264015033 classical (c) SDRs; Region: SDR_c; cd05233 266264015034 NAD(P) binding site [chemical binding]; other site 266264015035 active site 266264015036 threonine and homoserine efflux system; Provisional; Region: PRK10532 266264015037 EamA-like transporter family; Region: EamA; cl01037 266264015038 Helix-turn-helix domains; Region: HTH; cl00088 266264015039 nitrate transmembrane transporter; Provisional; Region: PLN00028 266264015040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015041 nitrite reductase subunit NirD; Provisional; Region: PRK14989 266264015042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264015043 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 266264015044 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266264015045 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 266264015046 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 266264015047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264015048 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266264015049 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 266264015050 [4Fe-4S] binding site [ion binding]; other site 266264015051 molybdopterin cofactor binding site; other site 266264015052 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 266264015053 molybdopterin cofactor binding site; other site 266264015054 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 266264015055 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 266264015056 TIGR03549 family protein; Region: TIGR03549 266264015057 OsmC-like protein; Region: OsmC; cl00767 266264015058 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 266264015059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 266264015060 YheO-like PAS domain; Region: PAS_6; pfam08348 266264015061 Helix-turn-helix domains; Region: HTH; cl00088 266264015062 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266264015063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264015064 serine racemase; Region: PLN02970 266264015065 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266264015066 tetramer interface [polypeptide binding]; other site 266264015067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264015068 catalytic residue [active] 266264015069 putative transporter; Provisional; Region: PRK10504 266264015070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015071 putative substrate translocation pore; other site 266264015072 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 266264015073 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 266264015074 NAD binding site [chemical binding]; other site 266264015075 substrate binding site [chemical binding]; other site 266264015076 active site 266264015077 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266264015078 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 266264015079 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 266264015080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015081 active site 266264015082 phosphorylation site [posttranslational modification] 266264015083 intermolecular recognition site; other site 266264015084 dimerization interface [polypeptide binding]; other site 266264015085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264015086 DNA binding site [nucleotide binding] 266264015087 sensor protein QseC; Provisional; Region: PRK10337 266264015088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264015089 dimer interface [polypeptide binding]; other site 266264015090 phosphorylation site [posttranslational modification] 266264015091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015092 ATP binding site [chemical binding]; other site 266264015093 Mg2+ binding site [ion binding]; other site 266264015094 G-X-G motif; other site 266264015095 Chromate transporter; Region: Chromate_transp; pfam02417 266264015096 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 266264015097 Chromate transporter; Region: Chromate_transp; pfam02417 266264015098 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 266264015099 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264015100 trimer interface [polypeptide binding]; other site 266264015101 eyelet of channel; other site 266264015102 Transglycosylase; Region: Transgly; cl07896 266264015103 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264015104 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 266264015105 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264015106 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 266264015107 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 266264015108 catabolite control protein A; Region: ccpA; TIGR01481 266264015109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266264015110 DNA binding site [nucleotide binding] 266264015111 domain linker motif; other site 266264015112 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 266264015113 putative dimerization interface [polypeptide binding]; other site 266264015114 putative ligand binding site [chemical binding]; other site 266264015115 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 266264015116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264015117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264015118 dimer interface [polypeptide binding]; other site 266264015119 conserved gate region; other site 266264015120 putative PBP binding loops; other site 266264015121 ABC-ATPase subunit interface; other site 266264015122 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266264015123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264015124 dimer interface [polypeptide binding]; other site 266264015125 conserved gate region; other site 266264015126 putative PBP binding loops; other site 266264015127 ABC-ATPase subunit interface; other site 266264015128 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266264015129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264015130 Walker A/P-loop; other site 266264015131 ATP binding site [chemical binding]; other site 266264015132 Q-loop/lid; other site 266264015133 ABC transporter signature motif; other site 266264015134 Walker B; other site 266264015135 D-loop; other site 266264015136 H-loop/switch region; other site 266264015137 TOBE domain; Region: TOBE_2; cl01440 266264015138 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 266264015139 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264015140 active site 266264015141 metal binding site [ion binding]; metal-binding site 266264015142 hexamer interface [polypeptide binding]; other site 266264015143 conserved hypothetical protein 266264015144 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266264015145 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 266264015146 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 266264015147 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266264015148 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 266264015149 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 266264015150 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 266264015151 PhnA protein; Region: PhnA; pfam03831 266264015152 EamA-like transporter family; Region: EamA; cl01037 266264015153 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266264015154 EamA-like transporter family; Region: EamA; cl01037 266264015155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264015156 Helix-turn-helix domains; Region: HTH; cl00088 266264015157 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264015158 putative effector binding pocket; other site 266264015159 dimerization interface [polypeptide binding]; other site 266264015160 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264015161 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264015162 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266264015163 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 266264015164 NAD(P) binding site [chemical binding]; other site 266264015165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015166 NMT1-like family; Region: NMT1_2; cl15260 266264015167 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264015168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015169 active site 266264015170 phosphorylation site [posttranslational modification] 266264015171 intermolecular recognition site; other site 266264015172 dimerization interface [polypeptide binding]; other site 266264015173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264015174 DNA binding residues [nucleotide binding] 266264015175 dimerization interface [polypeptide binding]; other site 266264015176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264015177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264015178 dimer interface [polypeptide binding]; other site 266264015179 phosphorylation site [posttranslational modification] 266264015180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015181 ATP binding site [chemical binding]; other site 266264015182 Mg2+ binding site [ion binding]; other site 266264015183 G-X-G motif; other site 266264015184 Response regulator receiver domain; Region: Response_reg; pfam00072 266264015185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015186 active site 266264015187 phosphorylation site [posttranslational modification] 266264015188 intermolecular recognition site; other site 266264015189 dimerization interface [polypeptide binding]; other site 266264015190 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264015191 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 266264015192 NAD(P) binding site [chemical binding]; other site 266264015193 catalytic residues [active] 266264015194 Protein of unknown function (DUF465); Region: DUF465; cl01070 266264015195 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266264015196 active site 266264015197 FMN binding site [chemical binding]; other site 266264015198 substrate binding site [chemical binding]; other site 266264015199 homotetramer interface [polypeptide binding]; other site 266264015200 catalytic residue [active] 266264015201 Penicillin amidase; Region: Penicil_amidase; pfam01804 266264015202 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266264015203 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 266264015204 active site 266264015205 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266264015206 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266264015207 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266264015208 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 266264015209 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264015210 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 266264015211 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264015212 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264015213 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264015214 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264015215 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266264015216 substrate binding pocket [chemical binding]; other site 266264015217 hypothetical protein 266264015218 transcriptional regulator; Provisional; Region: PRK10632 266264015219 Helix-turn-helix domains; Region: HTH; cl00088 266264015220 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266264015221 putative effector binding pocket; other site 266264015222 putative dimerization interface [polypeptide binding]; other site 266264015223 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 266264015224 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 266264015225 metal binding site [ion binding]; metal-binding site 266264015226 dimer interface [polypeptide binding]; other site 266264015227 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266264015228 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266264015229 conserved cys residue [active] 266264015230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264015231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264015232 BON domain; Region: BON; cl02771 266264015233 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 266264015234 BON domain; Region: BON; cl02771 266264015235 BON domain; Region: BON; cl02771 266264015236 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 266264015237 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 266264015238 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266264015239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015240 NMT1-like family; Region: NMT1_2; cl15260 266264015241 Muconolactone delta-isomerase; Region: MIase; cl01992 266264015242 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 266264015243 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 266264015244 octamer interface [polypeptide binding]; other site 266264015245 active site 266264015246 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264015247 Helix-turn-helix domains; Region: HTH; cl00088 266264015248 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264015249 dimerization interface [polypeptide binding]; other site 266264015250 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264015251 Helix-turn-helix domains; Region: HTH; cl00088 266264015252 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 266264015253 dimerizarion interface [polypeptide binding]; other site 266264015254 CrgA pocket; other site 266264015255 substrate binding pocket [chemical binding]; other site 266264015256 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 266264015257 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 266264015258 dimer interface [polypeptide binding]; other site 266264015259 active site 266264015260 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 266264015261 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 266264015262 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 266264015263 putative alpha subunit interface [polypeptide binding]; other site 266264015264 putative active site [active] 266264015265 putative substrate binding site [chemical binding]; other site 266264015266 Fe binding site [ion binding]; other site 266264015267 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266264015268 inter-subunit interface; other site 266264015269 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 266264015270 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264015271 catalytic loop [active] 266264015272 iron binding site [ion binding]; other site 266264015273 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 266264015274 FAD binding pocket [chemical binding]; other site 266264015275 FAD binding motif [chemical binding]; other site 266264015276 phosphate binding motif [ion binding]; other site 266264015277 beta-alpha-beta structure motif; other site 266264015278 NAD binding pocket [chemical binding]; other site 266264015279 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264015280 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 266264015281 putative NAD(P) binding site [chemical binding]; other site 266264015282 active site 266264015283 OpgC protein; Region: OpgC_C; cl00792 266264015284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264015285 Helix-turn-helix domains; Region: HTH; cl00088 266264015286 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 266264015287 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264015288 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264015289 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 266264015290 catalytic triad [active] 266264015291 dimer interface [polypeptide binding]; other site 266264015292 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266264015293 hypothetical protein; Provisional; Region: PRK06156 266264015294 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 266264015295 active site 266264015296 metal binding site [ion binding]; metal-binding site 266264015297 sulfite:cytochrome c oxidoreductase subunit A (SorA), molybdopterin binding domain. SorA is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SorB, a small c-type heme containing subunit, it forms a hetrodimer. It; Region: bact_SorA_Moco; cd02114 266264015298 Moco binding site; other site 266264015299 metal coordination site [ion binding]; other site 266264015300 putative dimerization interface [polypeptide binding]; other site 266264015301 Cytochrome c; Region: Cytochrom_C; cl11414 266264015302 Cytochrome c; Region: Cytochrom_C; cl11414 266264015303 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 266264015304 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264015305 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264015306 ligand binding site [chemical binding]; other site 266264015307 flexible hinge region; other site 266264015308 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 266264015309 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266264015310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264015311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264015312 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 266264015313 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 266264015314 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264015315 Predicted ATPase [General function prediction only]; Region: COG3910 266264015316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264015317 Walker A/P-loop; other site 266264015318 ATP binding site [chemical binding]; other site 266264015319 Q-loop/lid; other site 266264015320 ABC transporter signature motif; other site 266264015321 Walker B; other site 266264015322 D-loop; other site 266264015323 H-loop/switch region; other site 266264015324 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266264015325 active site 266264015326 nucleophile elbow; other site 266264015327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264015328 non-specific DNA binding site [nucleotide binding]; other site 266264015329 salt bridge; other site 266264015330 sequence-specific DNA binding site [nucleotide binding]; other site 266264015331 HipA N-terminal domain; Region: Couple_hipA; cl11853 266264015332 HipA-like N-terminal domain; Region: HipA_N; pfam07805 266264015333 HipA-like C-terminal domain; Region: HipA_C; pfam07804 266264015334 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264015335 classical (c) SDRs; Region: SDR_c; cd05233 266264015336 NAD(P) binding site [chemical binding]; other site 266264015337 active site 266264015338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264015339 Helix-turn-helix domains; Region: HTH; cl00088 266264015340 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264015341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015342 putative substrate translocation pore; other site 266264015343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264015344 Helix-turn-helix domains; Region: HTH; cl00088 266264015345 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 266264015346 putative dimerization interface [polypeptide binding]; other site 266264015347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264015348 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 266264015349 putative metal binding site [ion binding]; other site 266264015350 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264015351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264015352 Helix-turn-helix domains; Region: HTH; cl00088 266264015353 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266264015354 putative catalytic site [active] 266264015355 putative phosphate binding site [ion binding]; other site 266264015356 active site 266264015357 metal binding site A [ion binding]; metal-binding site 266264015358 DNA binding site [nucleotide binding] 266264015359 putative AP binding site [nucleotide binding]; other site 266264015360 putative metal binding site B [ion binding]; other site 266264015361 NosL; Region: NosL; cl01769 266264015362 NosL; Region: NosL; cl01769 266264015363 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266264015364 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266264015365 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 266264015366 Walker A/P-loop; other site 266264015367 ATP binding site [chemical binding]; other site 266264015368 Q-loop/lid; other site 266264015369 ABC transporter signature motif; other site 266264015370 Walker B; other site 266264015371 D-loop; other site 266264015372 H-loop/switch region; other site 266264015373 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 266264015374 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 266264015375 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 266264015376 FMN-binding domain; Region: FMN_bind; cl01081 266264015377 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 266264015378 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266264015379 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266264015380 nitrous-oxide reductase; Validated; Region: PRK02888 266264015381 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264015382 Cytochrome c; Region: Cytochrom_C; cl11414 266264015383 ApbE family; Region: ApbE; cl00643 266264015384 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266264015385 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 266264015386 putative acyl-acceptor binding pocket; other site 266264015387 DGC domain; Region: DGC; cl01742 266264015388 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 266264015389 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266264015390 catalytic residues [active] 266264015391 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264015392 Helix-turn-helix domains; Region: HTH; cl00088 266264015393 AsnC family; Region: AsnC_trans_reg; pfam01037 266264015394 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 266264015395 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 266264015396 dimer interface [polypeptide binding]; other site 266264015397 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 266264015398 active site 266264015399 Fe binding site [ion binding]; other site 266264015400 aromatic amino acid transporter; Provisional; Region: PRK10238 266264015401 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 266264015402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264015403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264015404 homodimer interface [polypeptide binding]; other site 266264015405 catalytic residue [active] 266264015406 lysine transporter; Provisional; Region: PRK10836 266264015407 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266264015408 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264015409 C-terminal domain interface [polypeptide binding]; other site 266264015410 GSH binding site (G-site) [chemical binding]; other site 266264015411 dimer interface [polypeptide binding]; other site 266264015412 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 266264015413 dimer interface [polypeptide binding]; other site 266264015414 N-terminal domain interface [polypeptide binding]; other site 266264015415 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264015416 Helix-turn-helix domains; Region: HTH; cl00088 266264015417 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264015418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015419 NMT1-like family; Region: NMT1_2; cl15260 266264015420 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 266264015421 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266264015422 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266264015423 FMN-binding pocket [chemical binding]; other site 266264015424 flavin binding motif; other site 266264015425 phosphate binding motif [ion binding]; other site 266264015426 beta-alpha-beta structure motif; other site 266264015427 NAD binding pocket [chemical binding]; other site 266264015428 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264015429 catalytic loop [active] 266264015430 iron binding site [ion binding]; other site 266264015431 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266264015432 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266264015433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015434 active site 266264015435 phosphorylation site [posttranslational modification] 266264015436 intermolecular recognition site; other site 266264015437 dimerization interface [polypeptide binding]; other site 266264015438 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 266264015439 H-NS histone family; Region: Histone_HNS; pfam00816 266264015440 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 266264015441 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264015442 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264015443 SCP-2 sterol transfer family; Region: SCP2; cl01225 266264015444 Peptidase family U32; Region: Peptidase_U32; cl03113 266264015445 Peptidase family U32; Region: Peptidase_U32; cl03113 266264015446 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264015447 Helix-turn-helix domains; Region: HTH; cl00088 266264015448 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264015449 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264015450 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266264015451 tetramerization interface [polypeptide binding]; other site 266264015452 NAD(P) binding site [chemical binding]; other site 266264015453 catalytic residues [active] 266264015454 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 266264015455 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266264015456 putative active site [active] 266264015457 metal binding site [ion binding]; metal-binding site 266264015458 BON domain; Region: BON; cl02771 266264015459 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 266264015460 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 266264015461 active site 266264015462 oxalacetate binding site [chemical binding]; other site 266264015463 citrylCoA binding site [chemical binding]; other site 266264015464 coenzyme A binding site [chemical binding]; other site 266264015465 catalytic triad [active] 266264015466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015467 NMT1-like family; Region: NMT1_2; cl15260 266264015468 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264015469 classical (c) SDRs; Region: SDR_c; cd05233 266264015470 NAD(P) binding site [chemical binding]; other site 266264015471 active site 266264015472 acyl-CoA synthetase; Validated; Region: PRK06188 266264015473 AMP-binding enzyme; Region: AMP-binding; cl15778 266264015474 AMP-binding enzyme; Region: AMP-binding; cl15778 266264015475 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266264015476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266264015477 DNA binding site [nucleotide binding] 266264015478 domain linker motif; other site 266264015479 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 266264015480 putative dimerization interface [polypeptide binding]; other site 266264015481 putative ligand binding site [chemical binding]; other site 266264015482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015483 NMT1-like family; Region: NMT1_2; cl15260 266264015484 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264015485 classical (c) SDRs; Region: SDR_c; cd05233 266264015486 NAD(P) binding site [chemical binding]; other site 266264015487 active site 266264015488 Putative cyclase; Region: Cyclase; cl00814 266264015489 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264015490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264015491 DNA-binding site [nucleotide binding]; DNA binding site 266264015492 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264015493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264015494 homodimer interface [polypeptide binding]; other site 266264015495 catalytic residue [active] 266264015496 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 266264015497 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266264015498 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266264015499 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264015500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264015501 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266264015502 PapC N-terminal domain; Region: PapC_N; pfam13954 266264015503 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266264015504 PapC C-terminal domain; Region: PapC_C; pfam13953 266264015505 putative chaperone protein EcpD; Provisional; Region: PRK09926 266264015506 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266264015507 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266264015508 Fimbrial protein; Region: Fimbrial; cl01416 266264015509 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264015510 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 266264015511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264015512 dimer interface [polypeptide binding]; other site 266264015513 phosphorylation site [posttranslational modification] 266264015514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015515 ATP binding site [chemical binding]; other site 266264015516 Mg2+ binding site [ion binding]; other site 266264015517 G-X-G motif; other site 266264015518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015519 active site 266264015520 phosphorylation site [posttranslational modification] 266264015521 intermolecular recognition site; other site 266264015522 dimerization interface [polypeptide binding]; other site 266264015523 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264015524 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264015525 DNA binding residues [nucleotide binding] 266264015526 dimerization interface [polypeptide binding]; other site 266264015527 hypothetical protein 266264015528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264015529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015530 active site 266264015531 phosphorylation site [posttranslational modification] 266264015532 intermolecular recognition site; other site 266264015533 dimerization interface [polypeptide binding]; other site 266264015534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264015535 DNA binding residues [nucleotide binding] 266264015536 dimerization interface [polypeptide binding]; other site 266264015537 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264015538 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264015539 substrate binding pocket [chemical binding]; other site 266264015540 membrane-bound complex binding site; other site 266264015541 hinge residues; other site 266264015542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264015543 dimer interface [polypeptide binding]; other site 266264015544 phosphorylation site [posttranslational modification] 266264015545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015546 ATP binding site [chemical binding]; other site 266264015547 Mg2+ binding site [ion binding]; other site 266264015548 G-X-G motif; other site 266264015549 Response regulator receiver domain; Region: Response_reg; pfam00072 266264015550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015551 active site 266264015552 phosphorylation site [posttranslational modification] 266264015553 intermolecular recognition site; other site 266264015554 dimerization interface [polypeptide binding]; other site 266264015555 hypothetical protein 266264015556 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 266264015557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015558 NMT1-like family; Region: NMT1_2; cl15260 266264015559 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264015560 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264015561 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264015562 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264015563 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266264015564 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264015565 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264015566 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266264015567 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 266264015568 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264015569 carboxyltransferase (CT) interaction site; other site 266264015570 biotinylation site [posttranslational modification]; other site 266264015571 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 266264015572 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266264015573 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266264015574 Integrase core domain; Region: rve; cl01316 266264015575 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266264015576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264015577 TniQ; Region: TniQ; pfam06527 266264015578 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264015579 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264015580 catalytic residues [active] 266264015581 catalytic nucleophile [active] 266264015582 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264015583 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264015584 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264015585 Synaptic Site I dimer interface [polypeptide binding]; other site 266264015586 DNA binding site [nucleotide binding] 266264015587 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264015588 DNA-binding interface [nucleotide binding]; DNA binding site 266264015589 EamA-like transporter family; Region: EamA; cl01037 266264015590 sensor protein QseC; Provisional; Region: PRK10337 266264015591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264015592 dimer interface [polypeptide binding]; other site 266264015593 phosphorylation site [posttranslational modification] 266264015594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015595 ATP binding site [chemical binding]; other site 266264015596 Mg2+ binding site [ion binding]; other site 266264015597 G-X-G motif; other site 266264015598 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264015599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015600 active site 266264015601 phosphorylation site [posttranslational modification] 266264015602 intermolecular recognition site; other site 266264015603 dimerization interface [polypeptide binding]; other site 266264015604 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264015605 DNA binding site [nucleotide binding] 266264015606 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264015607 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264015608 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264015609 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 266264015610 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264015611 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264015612 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264015613 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264015614 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 266264015615 active site 266264015616 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 266264015617 EamA-like transporter family; Region: EamA; cl01037 266264015618 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266264015619 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 266264015620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264015621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015622 active site 266264015623 phosphorylation site [posttranslational modification] 266264015624 intermolecular recognition site; other site 266264015625 dimerization interface [polypeptide binding]; other site 266264015626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264015627 DNA binding residues [nucleotide binding] 266264015628 dimerization interface [polypeptide binding]; other site 266264015629 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 266264015630 Histidine kinase; Region: HisKA_3; pfam07730 266264015631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015632 ATP binding site [chemical binding]; other site 266264015633 Mg2+ binding site [ion binding]; other site 266264015634 G-X-G motif; other site 266264015635 NMT1-like family; Region: NMT1_2; cl15260 266264015636 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 266264015637 Lamin Tail Domain; Region: LTD; pfam00932 266264015638 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 266264015639 generic binding surface I; other site 266264015640 generic binding surface II; other site 266264015641 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 266264015642 putative active site [active] 266264015643 putative catalytic site [active] 266264015644 putative Mg binding site IVb [ion binding]; other site 266264015645 putative phosphate binding site [ion binding]; other site 266264015646 putative DNA binding site [nucleotide binding]; other site 266264015647 putative Mg binding site IVa [ion binding]; other site 266264015648 Rhomboid family; Region: Rhomboid; cl11446 266264015649 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264015650 trimer interface [polypeptide binding]; other site 266264015651 eyelet of channel; other site 266264015652 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264015653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015654 putative substrate translocation pore; other site 266264015655 benzoate transport; Region: 2A0115; TIGR00895 266264015656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015657 putative substrate translocation pore; other site 266264015658 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264015659 eyelet of channel; other site 266264015660 trimer interface [polypeptide binding]; other site 266264015661 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266264015662 potential protein location (hypothetical protein) that overlaps protein (conserved hypothetical protein) 266264015663 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 266264015664 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 266264015665 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264015666 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266264015667 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264015668 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264015669 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266264015670 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264015671 H+ Antiporter protein; Region: 2A0121; TIGR00900 266264015672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015673 putative substrate translocation pore; other site 266264015674 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264015675 Helix-turn-helix domains; Region: HTH; cl00088 266264015676 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266264015677 Isochorismatase family; Region: Isochorismatase; pfam00857 266264015678 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266264015679 catalytic triad [active] 266264015680 conserved cis-peptide bond; other site 266264015681 V-type ATP synthase subunit E; Provisional; Region: PRK02292 266264015682 CsbD-like; Region: CsbD; cl15799 266264015683 HI0933-like protein; Region: HI0933_like; pfam03486 266264015684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264015685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264015686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 266264015687 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 266264015688 mercuric reductase; Validated; Region: PRK06370 266264015689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264015690 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264015691 Cupin domain; Region: Cupin_2; cl09118 266264015692 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266264015693 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264015694 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264015695 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264015696 active site 266264015697 catalytic tetrad [active] 266264015698 choline dehydrogenase; Validated; Region: PRK02106 266264015699 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264015700 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 266264015701 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266264015702 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264015703 NAD binding site [chemical binding]; other site 266264015704 catalytic residues [active] 266264015705 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264015706 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264015707 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264015708 CoenzymeA binding site [chemical binding]; other site 266264015709 subunit interaction site [polypeptide binding]; other site 266264015710 PHB binding site; other site 266264015711 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264015712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264015713 DNA binding residues [nucleotide binding] 266264015714 dimerization interface [polypeptide binding]; other site 266264015715 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264015716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264015717 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264015718 DNA binding residues [nucleotide binding] 266264015719 dimerization interface [polypeptide binding]; other site 266264015720 feruloyl-CoA synthase; Reviewed; Region: PRK08180 266264015721 AMP-binding enzyme; Region: AMP-binding; cl15778 266264015722 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264015723 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264015724 active site 266264015725 lipid-transfer protein; Provisional; Region: PRK08256 266264015726 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264015727 active site 266264015728 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266264015729 active site 266264015730 catalytic site [active] 266264015731 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 266264015732 active site 266264015733 catalytic site [active] 266264015734 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264015735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264015736 NAD(P) binding site [chemical binding]; other site 266264015737 active site 266264015738 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 266264015739 active site 266264015740 catalytic triad [active] 266264015741 oxyanion hole [active] 266264015742 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 266264015743 Outer membrane efflux protein; Region: OEP; pfam02321 266264015744 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 266264015745 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264015746 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 266264015747 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264015748 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 266264015749 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 266264015750 potential protein location (hypothetical protein) that overlaps protein (conserved hypothetical protein) 266264015751 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264015752 CoenzymeA binding site [chemical binding]; other site 266264015753 subunit interaction site [polypeptide binding]; other site 266264015754 PHB binding site; other site 266264015755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015756 NMT1-like family; Region: NMT1_2; cl15260 266264015757 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 266264015758 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264015759 PYR/PP interface [polypeptide binding]; other site 266264015760 dimer interface [polypeptide binding]; other site 266264015761 TPP binding site [chemical binding]; other site 266264015762 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266264015763 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266264015764 TPP-binding site [chemical binding]; other site 266264015765 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264015766 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264015767 DNA-binding site [nucleotide binding]; DNA binding site 266264015768 FCD domain; Region: FCD; cl11656 266264015769 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264015770 metal binding site [ion binding]; metal-binding site 266264015771 active site 266264015772 I-site; other site 266264015773 Phasin protein; Region: Phasin_2; cl11491 266264015774 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266264015775 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264015776 Arginase family; Region: Arginase; cl00306 266264015777 putative proline-specific permease; Provisional; Region: proY; PRK10580 266264015778 Spore germination protein; Region: Spore_permease; cl15802 266264015779 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266264015780 active sites [active] 266264015781 tetramer interface [polypeptide binding]; other site 266264015782 urocanate hydratase; Provisional; Region: PRK05414 266264015783 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266264015784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264015785 DNA-binding site [nucleotide binding]; DNA binding site 266264015786 UTRA domain; Region: UTRA; cl01230 266264015787 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264015788 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266264015789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264015790 Walker A/P-loop; other site 266264015791 ATP binding site [chemical binding]; other site 266264015792 Q-loop/lid; other site 266264015793 ABC transporter signature motif; other site 266264015794 Walker B; other site 266264015795 D-loop; other site 266264015796 H-loop/switch region; other site 266264015797 ABC transporter; Region: ABC_tran_2; pfam12848 266264015798 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266264015799 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266264015800 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266264015801 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 266264015802 active site 266264015803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015804 NMT1-like family; Region: NMT1_2; cl15260 266264015805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 266264015806 Patatin phospholipase; Region: DUF3734; pfam12536 266264015807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264015808 Helix-turn-helix domains; Region: HTH; cl00088 266264015809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015810 NMT1-like family; Region: NMT1_2; cl15260 266264015811 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264015812 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266264015813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015814 NMT1-like family; Region: NMT1_2; cl15260 266264015815 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 266264015816 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 266264015817 active site 266264015818 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266264015819 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 266264015820 active site 266264015821 dimer interface [polypeptide binding]; other site 266264015822 metal binding site [ion binding]; metal-binding site 266264015823 META domain; Region: META; cl01245 266264015824 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 266264015825 putative hydrophobic ligand binding site [chemical binding]; other site 266264015826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015827 putative substrate translocation pore; other site 266264015828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 266264015829 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266264015830 conserved hypothetical protein; partial overlap with helicases 266264015831 O-methyltransferase; Region: Methyltransf_2; pfam00891 266264015832 conserved hypothetical protein; partial overlap 266264015833 methionine synthase; Provisional; Region: PRK01207 266264015834 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266264015835 substrate binding site [chemical binding]; other site 266264015836 THF binding site; other site 266264015837 zinc-binding site [ion binding]; other site 266264015838 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 266264015839 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264015840 conserved hypothetical protein, partial overlap with arylsulfatase 266264015841 conserved hypothetical protein, partial overlap with arylsulfatase 266264015842 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266264015843 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 266264015844 Domain of unknown function (DUF802); Region: DUF802; pfam05650 266264015845 hypothetical protein; Provisional; Region: PRK09040 266264015846 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264015847 ligand binding site [chemical binding]; other site 266264015848 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 266264015849 Cupin domain; Region: Cupin_2; cl09118 266264015850 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266264015851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264015852 non-specific DNA binding site [nucleotide binding]; other site 266264015853 salt bridge; other site 266264015854 sequence-specific DNA binding site [nucleotide binding]; other site 266264015855 Cupin domain; Region: Cupin_2; cl09118 266264015856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264015857 FAD dependent oxidoreductase; Region: DAO; pfam01266 266264015858 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266264015859 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266264015860 MlrC C-terminus; Region: MlrC_C; pfam07171 266264015861 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 266264015862 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266264015863 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266264015864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264015865 dimer interface [polypeptide binding]; other site 266264015866 conserved gate region; other site 266264015867 putative PBP binding loops; other site 266264015868 ABC-ATPase subunit interface; other site 266264015869 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266264015870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266264015871 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266264015872 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264015873 Walker A/P-loop; other site 266264015874 ATP binding site [chemical binding]; other site 266264015875 Q-loop/lid; other site 266264015876 ABC transporter signature motif; other site 266264015877 Walker B; other site 266264015878 D-loop; other site 266264015879 H-loop/switch region; other site 266264015880 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264015881 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266264015882 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266264015883 Walker A/P-loop; other site 266264015884 ATP binding site [chemical binding]; other site 266264015885 Q-loop/lid; other site 266264015886 ABC transporter signature motif; other site 266264015887 Walker B; other site 266264015888 D-loop; other site 266264015889 H-loop/switch region; other site 266264015890 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264015891 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 266264015892 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 266264015893 active site 266264015894 putative substrate binding pocket [chemical binding]; other site 266264015895 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264015896 Lipopolysaccharide biosynthesis precursor (fragment) 266264015897 enoyl-CoA hydratase; Provisional; Region: PRK08260 266264015898 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264015899 substrate binding site [chemical binding]; other site 266264015900 oxyanion hole (OAH) forming residues; other site 266264015901 trimer interface [polypeptide binding]; other site 266264015902 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266264015903 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 266264015904 dimer interface [polypeptide binding]; other site 266264015905 NADP binding site [chemical binding]; other site 266264015906 catalytic residues [active] 266264015907 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266264015908 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266264015909 inhibitor site; inhibition site 266264015910 active site 266264015911 dimer interface [polypeptide binding]; other site 266264015912 catalytic residue [active] 266264015913 metabolite-proton symporter; Region: 2A0106; TIGR00883 266264015914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015915 putative substrate translocation pore; other site 266264015916 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264015917 DNA-binding site [nucleotide binding]; DNA binding site 266264015918 FCD domain; Region: FCD; cl11656 266264015919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264015920 DNA-binding site [nucleotide binding]; DNA binding site 266264015921 FCD domain; Region: FCD; cl11656 266264015922 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264015923 Helix-turn-helix domains; Region: HTH; cl00088 266264015924 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 266264015925 substrate binding pocket [chemical binding]; other site 266264015926 dimerization interface [polypeptide binding]; other site 266264015927 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266264015928 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266264015929 NAD(P) binding site [chemical binding]; other site 266264015930 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266264015931 NADP+ binding site [chemical binding]; other site 266264015932 folate binding site [chemical binding]; other site 266264015933 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 266264015934 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264015935 active site 266264015936 nucleotide binding site [chemical binding]; other site 266264015937 HIGH motif; other site 266264015938 KMSKS motif; other site 266264015939 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266264015940 nudix motif; other site 266264015941 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 266264015942 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 266264015943 active site 266264015944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264015945 Helix-turn-helix domains; Region: HTH; cl00088 266264015946 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264015947 putative dimerization interface [polypeptide binding]; other site 266264015948 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264015949 enoyl-CoA hydratase; Provisional; Region: PRK06688 266264015950 substrate binding site [chemical binding]; other site 266264015951 oxyanion hole (OAH) forming residues; other site 266264015952 trimer interface [polypeptide binding]; other site 266264015953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015954 NMT1-like family; Region: NMT1_2; cl15260 266264015955 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264015956 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264015957 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266264015958 substrate binding site [chemical binding]; other site 266264015959 oxyanion hole (OAH) forming residues; other site 266264015960 trimer interface [polypeptide binding]; other site 266264015961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264015962 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264015963 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264015964 thiolase; Provisional; Region: PRK06158 266264015965 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264015966 active site 266264015967 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264015968 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264015969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264015970 NMT1-like family; Region: NMT1_2; cl15260 266264015971 glutamate dehydrogenase; Provisional; Region: PRK09414 266264015972 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 266264015973 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 266264015974 NAD(P) binding site [chemical binding]; other site 266264015975 LysE type translocator; Region: LysE; cl00565 266264015976 Fimbrial protein; Region: Fimbrial; cl01416 266264015977 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264015978 active site 266264015979 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264015980 trimer interface [polypeptide binding]; other site 266264015981 eyelet of channel; other site 266264015982 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264015983 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264015984 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266264015985 TOBE domain; Region: TOBE_2; cl01440 266264015986 TOBE domain; Region: TOBE_2; cl01440 266264015987 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 266264015988 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266264015989 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266264015990 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 266264015991 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266264015992 NAD(P) binding site [chemical binding]; other site 266264015993 homotetramer interface [polypeptide binding]; other site 266264015994 homodimer interface [polypeptide binding]; other site 266264015995 active site 266264015996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 266264015997 AAA domain; Region: AAA_33; pfam13671 266264015998 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264015999 active site 266264016000 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 266264016001 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 266264016002 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 266264016003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264016004 Walker A motif; other site 266264016005 ATP binding site [chemical binding]; other site 266264016006 Walker B motif; other site 266264016007 arginine finger; other site 266264016008 Helix-turn-helix domains; Region: HTH; cl00088 266264016009 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266264016010 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264016011 NAD(P) binding site [chemical binding]; other site 266264016012 catalytic residues [active] 266264016013 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264016014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266264016015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016016 ATP binding site [chemical binding]; other site 266264016017 Mg2+ binding site [ion binding]; other site 266264016018 G-X-G motif; other site 266264016019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264016020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016021 active site 266264016022 phosphorylation site [posttranslational modification] 266264016023 intermolecular recognition site; other site 266264016024 dimerization interface [polypeptide binding]; other site 266264016025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264016026 DNA binding site [nucleotide binding] 266264016027 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 266264016028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016029 NMT1-like family; Region: NMT1_2; cl15260 266264016030 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264016031 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266264016032 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264016033 active site 266264016034 acyl-CoA synthetase; Validated; Region: PRK06188 266264016035 AMP-binding enzyme; Region: AMP-binding; cl15778 266264016036 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264016037 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 266264016038 Helix-turn-helix domains; Region: HTH; cl00088 266264016039 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264016040 dimerization interface [polypeptide binding]; other site 266264016041 Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851 266264016042 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 266264016043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264016044 FeS/SAM binding site; other site 266264016045 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 266264016046 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 266264016047 Class III ribonucleotide reductase; Region: RNR_III; cd01675 266264016048 effector binding site; other site 266264016049 active site 266264016050 Zn binding site [ion binding]; other site 266264016051 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264016052 AMP-binding enzyme; Region: AMP-binding; cl15778 266264016053 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264016054 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264016055 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016056 active site 266264016057 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264016058 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264016059 active site 266264016060 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016061 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016062 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264016063 active site 266264016064 enoyl-CoA hydratase; Provisional; Region: PRK09245 266264016065 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016066 substrate binding site [chemical binding]; other site 266264016067 oxyanion hole (OAH) forming residues; other site 266264016068 trimer interface [polypeptide binding]; other site 266264016069 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 266264016070 putative active site [active] 266264016071 putative catalytic site [active] 266264016072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016073 NMT1-like family; Region: NMT1_2; cl15260 266264016074 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264016075 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264016076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016077 NMT1-like family; Region: NMT1_2; cl15260 266264016078 enoyl-CoA hydratase; Provisional; Region: PRK09245 266264016079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016080 substrate binding site [chemical binding]; other site 266264016081 oxyanion hole (OAH) forming residues; other site 266264016082 trimer interface [polypeptide binding]; other site 266264016083 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264016084 Helix-turn-helix domains; Region: HTH; cl00088 266264016085 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264016086 dimerization interface [polypeptide binding]; other site 266264016087 substrate binding pocket [chemical binding]; other site 266264016088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264016089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016090 active site 266264016091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016092 NMT1-like family; Region: NMT1_2; cl15260 266264016093 enoyl-CoA hydratase; Provisional; Region: PRK08252 266264016094 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016095 substrate binding site [chemical binding]; other site 266264016096 oxyanion hole (OAH) forming residues; other site 266264016097 trimer interface [polypeptide binding]; other site 266264016098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016099 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264016100 NAD(P) binding site [chemical binding]; other site 266264016101 active site 266264016102 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 266264016103 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264016104 dimer interface [polypeptide binding]; other site 266264016105 active site 266264016106 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264016107 Helix-turn-helix domains; Region: HTH; cl00088 266264016108 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264016109 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 266264016110 AMP-binding enzyme; Region: AMP-binding; cl15778 266264016111 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264016112 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 266264016113 Helix-turn-helix domains; Region: HTH; cl00088 266264016114 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 266264016115 putative substrate binding pocket [chemical binding]; other site 266264016116 putative dimerization interface [polypeptide binding]; other site 266264016117 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264016118 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 266264016119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016120 NMT1-like family; Region: NMT1_2; cl15260 266264016121 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264016122 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266264016123 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264016124 autotransporter (fragment) 266264016125 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 266264016126 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264016127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016128 active site 266264016129 phosphorylation site [posttranslational modification] 266264016130 intermolecular recognition site; other site 266264016131 dimerization interface [polypeptide binding]; other site 266264016132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016133 DNA binding residues [nucleotide binding] 266264016134 dimerization interface [polypeptide binding]; other site 266264016135 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 266264016136 Histidine kinase; Region: HisKA_3; pfam07730 266264016137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 266264016138 High potential iron-sulfur protein; Region: HIPIP; pfam01355 266264016139 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 266264016140 Helix-turn-helix domains; Region: HTH; cl00088 266264016141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264016142 dimerization interface [polypeptide binding]; other site 266264016143 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 266264016144 nudix motif; other site 266264016145 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266264016146 DNA-binding site [nucleotide binding]; DNA binding site 266264016147 RNA-binding motif; other site 266264016148 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266264016149 rRNA binding site [nucleotide binding]; other site 266264016150 predicted 30S ribosome binding site; other site 266264016151 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 266264016152 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266264016153 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264016154 CoenzymeA binding site [chemical binding]; other site 266264016155 subunit interaction site [polypeptide binding]; other site 266264016156 PHB binding site; other site 266264016157 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 266264016158 active site clefts [active] 266264016159 zinc binding site [ion binding]; other site 266264016160 dimer interface [polypeptide binding]; other site 266264016161 voltage-gated potassium channel; Provisional; Region: PRK10537 266264016162 Ion channel; Region: Ion_trans_2; cl11596 266264016163 Cadherin repeat-like domain; Region: CA_like; cl15786 266264016164 Galactose oxidase, central domain; Region: Kelch_3; cl02701 266264016165 Galactose oxidase, central domain; Region: Kelch_3; cl02701 266264016166 Galactose oxidase, central domain; Region: Kelch_3; cl02701 266264016167 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264016168 dimerization interface [polypeptide binding]; other site 266264016169 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266264016170 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264016171 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264016172 trimer interface [polypeptide binding]; other site 266264016173 eyelet of channel; other site 266264016174 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 266264016175 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 266264016176 kynureninase; Region: kynureninase; TIGR01814 266264016177 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264016178 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264016179 catalytic residue [active] 266264016180 Cupin domain; Region: Cupin_2; cl09118 266264016181 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266264016182 Helix-turn-helix domains; Region: HTH; cl00088 266264016183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264016184 dimerization interface [polypeptide binding]; other site 266264016185 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264016186 trimer interface [polypeptide binding]; other site 266264016187 eyelet of channel; other site 266264016188 Cytochrome c; Region: Cytochrom_C; cl11414 266264016189 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266264016190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016191 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264016192 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264016193 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 266264016194 active site 266264016195 metal binding site [ion binding]; metal-binding site 266264016196 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264016197 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266264016198 substrate binding pocket [chemical binding]; other site 266264016199 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266264016200 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266264016201 inhibitor site; inhibition site 266264016202 active site 266264016203 dimer interface [polypeptide binding]; other site 266264016204 catalytic residue [active] 266264016205 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264016206 homotrimer interaction site [polypeptide binding]; other site 266264016207 putative active site [active] 266264016208 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 266264016209 putative FMN binding site [chemical binding]; other site 266264016210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016211 NMT1-like family; Region: NMT1_2; cl15260 266264016212 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264016213 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 266264016214 NAD binding site [chemical binding]; other site 266264016215 catalytic residues [active] 266264016216 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264016217 acetaldehyde dehydrogenase; Validated; Region: PRK08300 266264016218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016219 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 266264016220 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 266264016221 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 266264016222 active site 266264016223 catalytic residues [active] 266264016224 metal binding site [ion binding]; metal-binding site 266264016225 DmpG-like communication domain; Region: DmpG_comm; pfam07836 266264016226 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264016227 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264016228 homotrimer interaction site [polypeptide binding]; other site 266264016229 putative active site [active] 266264016230 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264016231 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264016232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264016233 DNA-binding site [nucleotide binding]; DNA binding site 266264016234 FCD domain; Region: FCD; cl11656 266264016235 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266264016236 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264016237 active site 266264016238 metal binding site [ion binding]; metal-binding site 266264016239 LssY C-terminus; Region: LssY_C; pfam14067 266264016240 LssY C-terminus; Region: LssY_C; pfam14067 266264016241 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 266264016242 putative amphipathic alpha helix; other site 266264016243 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264016244 Helix-turn-helix domains; Region: HTH; cl00088 266264016245 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264016246 dimerization interface [polypeptide binding]; other site 266264016247 substrate binding pocket [chemical binding]; other site 266264016248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016249 NMT1-like family; Region: NMT1_2; cl15260 266264016250 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266264016251 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266264016252 metal binding site [ion binding]; metal-binding site 266264016253 putative dimer interface [polypeptide binding]; other site 266264016254 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 266264016255 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 266264016256 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266264016257 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264016258 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264016259 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264016260 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266264016261 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264016262 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264016263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264016264 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264016265 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266264016266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016267 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264016268 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264016269 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264016270 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 266264016271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264016272 catalytic residue [active] 266264016273 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 266264016274 Predicted transcriptional regulators [Transcription]; Region: COG1510 266264016275 Helix-turn-helix domains; Region: HTH; cl00088 266264016276 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 266264016277 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 266264016278 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266264016279 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266264016280 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 266264016281 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266264016282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264016283 TPR motif; other site 266264016284 binding surface 266264016285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264016286 binding surface 266264016287 TPR motif; other site 266264016288 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 266264016289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264016290 TPR motif; other site 266264016291 binding surface 266264016292 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 266264016293 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266264016294 inhibitor-cofactor binding pocket; inhibition site 266264016295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264016296 catalytic residue [active] 266264016297 WbqC-like protein family; Region: WbqC; pfam08889 266264016298 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264016299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264016300 S-adenosylmethionine binding site [chemical binding]; other site 266264016301 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264016302 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 266264016303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264016304 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266264016305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264016306 S-adenosylmethionine binding site [chemical binding]; other site 266264016307 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264016308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016309 putative substrate translocation pore; other site 266264016310 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016311 Helix-turn-helix domains; Region: HTH; cl00088 266264016312 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 266264016313 putative substrate binding pocket [chemical binding]; other site 266264016314 putative dimerization interface [polypeptide binding]; other site 266264016315 Protein of unknown function, DUF606; Region: DUF606; cl01273 266264016316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016317 Helix-turn-helix domains; Region: HTH; cl00088 266264016318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264016319 dimerization interface [polypeptide binding]; other site 266264016320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016321 NMT1-like family; Region: NMT1_2; cl15260 266264016322 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264016323 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264016324 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264016325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264016326 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264016327 dimer interface [polypeptide binding]; other site 266264016328 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 266264016329 putative CheW interface [polypeptide binding]; other site 266264016330 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 266264016331 Sm1 motif; other site 266264016332 D1 - D2 interaction site; other site 266264016333 D3 - B interaction site; other site 266264016334 Hfq - Hfq interaction site; other site 266264016335 RNA binding pocket [nucleotide binding]; other site 266264016336 Sm2 motif; other site 266264016337 flagellin; Validated; Region: PRK06819 266264016338 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266264016339 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266264016340 FlaG protein; Region: FlaG; cl00591 266264016341 flagellar capping protein; Reviewed; Region: fliD; PRK08032 266264016342 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 266264016343 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 266264016344 Flagellar protein FliS; Region: FliS; cl00654 266264016345 Flagellar protein FliT; Region: FliT; cl05125 266264016346 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 266264016347 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 266264016348 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 266264016349 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 266264016350 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 266264016351 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 266264016352 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 266264016353 FliG C-terminal domain; Region: FliG_C; pfam01706 266264016354 flagellar assembly protein H; Validated; Region: fliH; PRK05687 266264016355 Flagellar assembly protein FliH; Region: FliH; pfam02108 266264016356 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 266264016357 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 266264016358 Walker A motif/ATP binding site; other site 266264016359 Walker B motif; other site 266264016360 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 266264016361 Flagellar FliJ protein; Region: FliJ; pfam02050 266264016362 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 266264016363 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264016364 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264016365 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264016366 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264016367 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266264016368 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266264016369 transmembrane helices; other site 266264016370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264016371 Dehydratase family; Region: ILVD_EDD; cl00340 266264016372 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 266264016373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016374 NMT1-like family; Region: NMT1_2; cl15260 266264016375 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266264016376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016377 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 266264016378 putative active site [active] 266264016379 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 266264016380 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 266264016381 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264016382 LysE type translocator; Region: LysE; cl00565 266264016383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016384 NMT1-like family; Region: NMT1_2; cl15260 266264016385 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 266264016386 Helix-turn-helix domains; Region: HTH; cl00088 266264016387 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266264016388 putative dimerization interface [polypeptide binding]; other site 266264016389 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266264016390 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264016391 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266264016392 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264016393 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 266264016394 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266264016395 ATP binding site [chemical binding]; other site 266264016396 Mg++ binding site [ion binding]; other site 266264016397 motif III; other site 266264016398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264016399 nucleotide binding region [chemical binding]; other site 266264016400 ATP-binding site [chemical binding]; other site 266264016401 DbpA RNA binding domain; Region: DbpA; pfam03880 266264016402 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266264016403 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266264016404 NADP binding site [chemical binding]; other site 266264016405 dimer interface [polypeptide binding]; other site 266264016406 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266264016407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016408 NMT1-like family; Region: NMT1_2; cl15260 266264016409 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264016410 eyelet of channel; other site 266264016411 trimer interface [polypeptide binding]; other site 266264016412 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264016413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016414 NAD(P) binding site [chemical binding]; other site 266264016415 active site 266264016416 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 266264016417 classical (c) SDRs; Region: SDR_c; cd05233 266264016418 NAD(P) binding site [chemical binding]; other site 266264016419 active site 266264016420 potential protein location (hypothetical protein) that overlaps protein (3-oxoacyl-ACP reductase (3-ketoacyl- acyl carrier protein reductase)) 266264016421 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266264016422 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264016423 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264016424 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266264016425 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264016426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016427 NMT1-like family; Region: NMT1_2; cl15260 266264016428 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264016429 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264016430 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 266264016431 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 266264016432 substrate binding site [chemical binding]; other site 266264016433 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 266264016434 substrate binding site [chemical binding]; other site 266264016435 ligand binding site [chemical binding]; other site 266264016436 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 266264016437 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 266264016438 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 266264016439 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 266264016440 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 266264016441 FliP family; Region: FliP; cl00593 266264016442 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 266264016443 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 266264016444 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264016445 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 266264016446 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 266264016447 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264016448 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264016449 dimer interface [polypeptide binding]; other site 266264016450 putative CheW interface [polypeptide binding]; other site 266264016451 NnrS protein; Region: NnrS; cl01258 266264016452 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 266264016453 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264016454 substrate binding site [chemical binding]; other site 266264016455 activation loop (A-loop); other site 266264016456 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264016457 Predicted ATPase [General function prediction only]; Region: COG3899 266264016458 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266264016459 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266264016460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016461 ATP binding site [chemical binding]; other site 266264016462 Mg2+ binding site [ion binding]; other site 266264016463 G-X-G motif; other site 266264016464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 266264016465 active site 266264016466 phosphorylation site [posttranslational modification] 266264016467 intermolecular recognition site; other site 266264016468 dimerization interface [polypeptide binding]; other site 266264016469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016470 DNA binding residues [nucleotide binding] 266264016471 dimerization interface [polypeptide binding]; other site 266264016472 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264016473 Isochorismatase family; Region: Isochorismatase; pfam00857 266264016474 catalytic triad [active] 266264016475 dimer interface [polypeptide binding]; other site 266264016476 conserved cis-peptide bond; other site 266264016477 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264016478 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264016479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016480 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266264016481 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266264016482 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266264016483 active site 266264016484 DoxX; Region: DoxX; cl00976 266264016485 Transmembrane secretion effector; Region: MFS_3; pfam05977 266264016486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016487 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 266264016488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016489 active site 266264016490 phosphorylation site [posttranslational modification] 266264016491 intermolecular recognition site; other site 266264016492 dimerization interface [polypeptide binding]; other site 266264016493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016494 active site 266264016495 phosphorylation site [posttranslational modification] 266264016496 intermolecular recognition site; other site 266264016497 dimerization interface [polypeptide binding]; other site 266264016498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016499 DNA binding residues [nucleotide binding] 266264016500 dimerization interface [polypeptide binding]; other site 266264016501 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264016502 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264016503 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264016504 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264016505 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264016506 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264016507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264016508 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264016509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264016510 dimer interface [polypeptide binding]; other site 266264016511 phosphorylation site [posttranslational modification] 266264016512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016513 ATP binding site [chemical binding]; other site 266264016514 Mg2+ binding site [ion binding]; other site 266264016515 G-X-G motif; other site 266264016516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016517 active site 266264016518 phosphorylation site [posttranslational modification] 266264016519 intermolecular recognition site; other site 266264016520 dimerization interface [polypeptide binding]; other site 266264016521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016522 DNA binding residues [nucleotide binding] 266264016523 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264016524 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264016525 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264016526 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 266264016527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016528 active site 266264016529 phosphorylation site [posttranslational modification] 266264016530 intermolecular recognition site; other site 266264016531 dimerization interface [polypeptide binding]; other site 266264016532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264016533 DNA binding site [nucleotide binding] 266264016534 sensor protein QseC; Provisional; Region: PRK10337 266264016535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264016536 dimer interface [polypeptide binding]; other site 266264016537 phosphorylation site [posttranslational modification] 266264016538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016539 ATP binding site [chemical binding]; other site 266264016540 Mg2+ binding site [ion binding]; other site 266264016541 G-X-G motif; other site 266264016542 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264016543 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264016544 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264016545 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264016546 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264016547 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264016548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016549 active site 266264016550 phosphorylation site [posttranslational modification] 266264016551 intermolecular recognition site; other site 266264016552 dimerization interface [polypeptide binding]; other site 266264016553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264016554 DNA binding site [nucleotide binding] 266264016555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264016556 dimerization interface [polypeptide binding]; other site 266264016557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264016558 dimer interface [polypeptide binding]; other site 266264016559 phosphorylation site [posttranslational modification] 266264016560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016561 ATP binding site [chemical binding]; other site 266264016562 Mg2+ binding site [ion binding]; other site 266264016563 G-X-G motif; other site 266264016564 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 266264016565 MgtC family; Region: MgtC; pfam02308 266264016566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264016567 Adenosine specific kinase; Region: Adenosine_kin; cl00796 266264016568 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 266264016569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 266264016570 TolB amino-terminal domain; Region: TolB_N; cl00639 266264016571 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 266264016572 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266264016573 Surface antigen; Region: Bac_surface_Ag; cl03097 266264016574 haemagglutination activity domain; Region: Haemagg_act; cl05436 266264016575 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 266264016576 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 266264016577 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 266264016578 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 266264016579 Cytochrome c [Energy production and conversion]; Region: COG3258 266264016580 Cytochrome c; Region: Cytochrom_C; cl11414 266264016581 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264016582 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 266264016583 PAS fold; Region: PAS_4; pfam08448 266264016584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264016585 putative active site [active] 266264016586 heme pocket [chemical binding]; other site 266264016587 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264016588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264016589 Walker A motif; other site 266264016590 ATP binding site [chemical binding]; other site 266264016591 Walker B motif; other site 266264016592 arginine finger; other site 266264016593 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264016594 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266264016595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016596 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264016597 putative substrate translocation pore; other site 266264016598 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266264016599 conserved hypothetical protein 266264016600 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 266264016601 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 266264016602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016603 NMT1-like family; Region: NMT1_2; cl15260 266264016604 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016605 active site 266264016606 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264016607 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016609 NMT1-like family; Region: NMT1_2; cl15260 266264016610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016611 Helix-turn-helix domains; Region: HTH; cl00088 266264016612 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 266264016613 substrate binding pocket [chemical binding]; other site 266264016614 dimerization interface [polypeptide binding]; other site 266264016615 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264016616 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016617 substrate binding site [chemical binding]; other site 266264016618 oxyanion hole (OAH) forming residues; other site 266264016619 trimer interface [polypeptide binding]; other site 266264016620 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264016621 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264016622 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266264016623 FMN binding site [chemical binding]; other site 266264016624 active site 266264016625 substrate binding site [chemical binding]; other site 266264016626 catalytic residue [active] 266264016627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264016628 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264016629 active site 266264016630 catalytic tetrad [active] 266264016631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016632 Helix-turn-helix domains; Region: HTH; cl00088 266264016633 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 266264016634 putative effector binding pocket; other site 266264016635 dimerization interface [polypeptide binding]; other site 266264016636 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 266264016637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016638 putative substrate translocation pore; other site 266264016639 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266264016640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016641 CoA-ligase; Region: Ligase_CoA; cl02894 266264016642 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266264016643 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266264016644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016645 Helix-turn-helix domains; Region: HTH; cl00088 266264016646 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264016647 putative dimerization interface [polypeptide binding]; other site 266264016648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016649 NMT1-like family; Region: NMT1_2; cl15260 266264016650 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 266264016651 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 266264016652 dimer interface [polypeptide binding]; other site 266264016653 active site 266264016654 heme binding site [chemical binding]; other site 266264016655 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 266264016656 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 266264016657 putative deacylase active site [active] 266264016658 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 266264016659 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264016660 N-terminal plug; other site 266264016661 ligand-binding site [chemical binding]; other site 266264016662 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 266264016663 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cl12009 266264016664 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 266264016665 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 266264016666 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 266264016667 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 266264016668 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266264016669 putative hemin binding site; other site 266264016670 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 266264016671 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266264016672 ABC-ATPase subunit interface; other site 266264016673 dimer interface [polypeptide binding]; other site 266264016674 putative PBP binding regions; other site 266264016675 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 266264016676 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266264016677 Walker A/P-loop; other site 266264016678 ATP binding site [chemical binding]; other site 266264016679 Q-loop/lid; other site 266264016680 ABC transporter signature motif; other site 266264016681 Walker B; other site 266264016682 D-loop; other site 266264016683 H-loop/switch region; other site 266264016684 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264016685 classical (c) SDRs; Region: SDR_c; cd05233 266264016686 NAD(P) binding site [chemical binding]; other site 266264016687 active site 266264016688 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 266264016689 active site 266264016690 oxalacetate binding site [chemical binding]; other site 266264016691 citrylCoA binding site [chemical binding]; other site 266264016692 coenzyme A binding site [chemical binding]; other site 266264016693 catalytic triad [active] 266264016694 acyl-CoA synthetase; Validated; Region: PRK06188 266264016695 AMP-binding enzyme; Region: AMP-binding; cl15778 266264016696 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264016697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016698 NMT1-like family; Region: NMT1_2; cl15260 266264016699 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264016700 Helix-turn-helix domains; Region: HTH; cl00088 266264016701 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264016702 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 266264016703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264016704 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 266264016705 ApbE family; Region: ApbE; cl00643 266264016706 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 266264016707 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 266264016708 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264016709 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 266264016710 FAD binding pocket [chemical binding]; other site 266264016711 FAD binding motif [chemical binding]; other site 266264016712 catalytic residues [active] 266264016713 NAD binding pocket [chemical binding]; other site 266264016714 phosphate binding motif [ion binding]; other site 266264016715 beta-alpha-beta structure motif; other site 266264016716 FlgD Ig-like domain; Region: FlgD_ig; cl15790 266264016717 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 266264016718 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 266264016719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016720 active site 266264016721 phosphorylation site [posttranslational modification] 266264016722 intermolecular recognition site; other site 266264016723 dimerization interface [polypeptide binding]; other site 266264016724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264016725 DNA binding site [nucleotide binding] 266264016726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264016727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264016728 dimer interface [polypeptide binding]; other site 266264016729 phosphorylation site [posttranslational modification] 266264016730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016731 ATP binding site [chemical binding]; other site 266264016732 Mg2+ binding site [ion binding]; other site 266264016733 G-X-G motif; other site 266264016734 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264016735 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266264016736 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 266264016737 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 266264016738 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264016739 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266264016740 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266264016741 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266264016742 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 266264016743 BON domain; Region: BON; cl02771 266264016744 Domain of unknown function (DUF305); Region: DUF305; cl15795 266264016745 Uncharacterized conserved protein [Function unknown]; Region: COG3391 266264016746 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266264016747 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266264016748 RNA polymerase sigma factor; Provisional; Region: PRK12511 266264016749 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264016750 DNA binding residues [nucleotide binding] 266264016751 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266264016752 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 266264016753 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264016754 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 266264016755 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 266264016756 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 266264016757 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016758 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016759 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016760 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016761 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016762 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016763 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016764 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016765 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016766 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016767 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264016768 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264016769 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264016770 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264016771 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264016772 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264016773 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 266264016774 active site 266264016775 putative substrate binding region [chemical binding]; other site 266264016776 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264016777 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264016778 Helix-turn-helix domains; Region: HTH; cl00088 266264016779 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 266264016780 NAD(P) binding site [chemical binding]; other site 266264016781 catalytic residues [active] 266264016782 choline dehydrogenase; Validated; Region: PRK02106 266264016783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016784 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264016785 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 266264016786 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264016787 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266264016788 Sulfatase; Region: Sulfatase; cl10460 266264016789 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 266264016790 Helix-turn-helix domains; Region: HTH; cl00088 266264016791 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264016792 dimerization interface [polypeptide binding]; other site 266264016793 citrate-proton symporter; Provisional; Region: PRK15075 266264016794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016795 putative substrate translocation pore; other site 266264016796 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266264016797 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266264016798 metal binding site [ion binding]; metal-binding site 266264016799 putative dimer interface [polypeptide binding]; other site 266264016800 NMT1-like family; Region: NMT1_2; cl15260 266264016801 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 266264016802 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266264016803 Sulfatase; Region: Sulfatase; cl10460 266264016804 Sulfatase; Region: Sulfatase; cl10460 266264016805 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264016806 Helix-turn-helix domains; Region: HTH; cl00088 266264016807 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264016808 dimerization interface [polypeptide binding]; other site 266264016809 substrate binding pocket [chemical binding]; other site 266264016810 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264016811 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264016812 active site 266264016813 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266264016814 putative acyl-acceptor binding pocket; other site 266264016815 enoyl-CoA hydratase; Provisional; Region: PRK07509 266264016816 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016817 substrate binding site [chemical binding]; other site 266264016818 oxyanion hole (OAH) forming residues; other site 266264016819 trimer interface [polypeptide binding]; other site 266264016820 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 266264016821 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264016822 dimer interface [polypeptide binding]; other site 266264016823 active site 266264016824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016825 NAD(P) binding site [chemical binding]; other site 266264016826 active site 266264016827 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264016828 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264016829 FMN binding site [chemical binding]; other site 266264016830 substrate binding site [chemical binding]; other site 266264016831 putative catalytic residue [active] 266264016832 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264016833 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264016834 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264016835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016836 DNA binding residues [nucleotide binding] 266264016837 dimerization interface [polypeptide binding]; other site 266264016838 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264016839 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016840 active site 266264016841 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264016842 AMP-binding enzyme; Region: AMP-binding; cl15778 266264016843 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264016844 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 266264016845 AMP-binding enzyme; Region: AMP-binding; cl15778 266264016846 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264016847 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264016848 active site 266264016849 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266264016850 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 266264016851 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264016852 FAD binding domain; Region: FAD_binding_4; pfam01565 266264016853 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 266264016854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016855 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 266264016856 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 266264016857 N- and C-terminal domain interface [polypeptide binding]; other site 266264016858 active site 266264016859 MgATP binding site [chemical binding]; other site 266264016860 catalytic site [active] 266264016861 metal binding site [ion binding]; metal-binding site 266264016862 carbohydrate binding site [chemical binding]; other site 266264016863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016864 putative substrate translocation pore; other site 266264016865 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 266264016866 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 266264016867 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264016868 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266264016869 putative transposase OrfB; Reviewed; Region: PHA02517 266264016870 HTH-like domain; Region: HTH_21; pfam13276 266264016871 Integrase core domain; Region: rve; cl01316 266264016872 Integrase core domain; Region: rve_3; cl15866 266264016873 Helix-turn-helix domains; Region: HTH; cl00088 266264016874 transposon Tn7 transposition protein TnsC (fragment) 266264016875 putative transposase OrfB; Reviewed; Region: PHA02517 266264016876 HTH-like domain; Region: HTH_21; pfam13276 266264016877 Integrase core domain; Region: rve; cl01316 266264016878 Integrase core domain; Region: rve_3; cl15866 266264016879 Helix-turn-helix domains; Region: HTH; cl00088 266264016880 Tn7-like transposition protein C 266264016881 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 266264016882 potential protein location (hypothetical protein) that overlaps protein (conserved hypothetical protein) 266264016883 Uncharacterized conserved protein [Function unknown]; Region: COG4127 266264016884 Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810 266264016885 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266264016886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264016887 DNA-binding site [nucleotide binding]; DNA binding site 266264016888 UTRA domain; Region: UTRA; cl01230 266264016889 Fumarase C-terminus; Region: Fumerase_C; cl00795 266264016890 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 266264016891 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 266264016892 putative active site pocket [active] 266264016893 metal binding site [ion binding]; metal-binding site 266264016894 NMT1-like family; Region: NMT1_2; cl15260 266264016895 conserved hypothetical protein (fragment) 266264016896 AAA domain; Region: AAA_22; pfam13401 266264016897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264016898 Walker A motif; other site 266264016899 ATP binding site [chemical binding]; other site 266264016900 Walker B motif; other site 266264016901 arginine finger; other site 266264016902 Integrase core domain; Region: rve; cl01316 266264016903 conserved hypothetical protein (fragment) 266264016904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 266264016905 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266264016906 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264016907 Family description; Region: UvrD_C_2; cl15862 266264016908 potential protein location (hypothetical protein) that overlaps protein ( ATP-dependent DNA helicase Rep) 266264016909 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 266264016910 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 266264016911 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 266264016912 putative active site [active] 266264016913 putative metal-binding site [ion binding]; other site 266264016914 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266264016915 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 266264016916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016918 NMT1-like family; Region: NMT1_2; cl15260 266264016919 putative succinate dehydrogenase; Reviewed; Region: PRK12842 266264016920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016921 NIPSNAP; Region: NIPSNAP; pfam07978 266264016922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016923 NMT1-like family; Region: NMT1_2; cl15260 266264016924 NADPH:quinone reductase, Zn-dependent (fragment) 266264016925 Helix-turn-helix domains; Region: HTH; cl00088 266264016926 putative transposase OrfB; Reviewed; Region: PHA02517 266264016927 HTH-like domain; Region: HTH_21; pfam13276 266264016928 Integrase core domain; Region: rve; cl01316 266264016929 Integrase core domain; Region: rve_3; cl15866 266264016930 NADPH:quinone reductase, Zn-dependent (fragment) 266264016931 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 266264016932 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264016933 active site 266264016934 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264016935 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264016936 enoyl-CoA hydratase; Provisional; Region: PRK06688 266264016937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016938 substrate binding site [chemical binding]; other site 266264016939 oxyanion hole (OAH) forming residues; other site 266264016940 trimer interface [polypeptide binding]; other site 266264016941 short chain dehydrogenase; Provisional; Region: PRK08278 266264016942 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 266264016943 NAD(P) binding site [chemical binding]; other site 266264016944 homodimer interface [polypeptide binding]; other site 266264016945 active site 266264016946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016947 NMT1-like family; Region: NMT1_2; cl15260 266264016948 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264016949 trimer interface [polypeptide binding]; other site 266264016950 eyelet of channel; other site 266264016951 enoyl-CoA hydratase; Provisional; Region: PRK12478 266264016952 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016953 substrate binding site [chemical binding]; other site 266264016954 oxyanion hole (OAH) forming residues; other site 266264016955 trimer interface [polypeptide binding]; other site 266264016956 Cupin domain; Region: Cupin_2; cl09118 266264016957 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264016958 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016959 active site 266264016960 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 266264016961 AMP-binding enzyme; Region: AMP-binding; cl15778 266264016962 AMP-binding enzyme; Region: AMP-binding; cl15778 266264016963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016964 NAD(P) binding site [chemical binding]; other site 266264016965 active site 266264016966 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 266264016967 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264016968 dimer interface [polypeptide binding]; other site 266264016969 active site 266264016970 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266264016971 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016972 substrate binding site [chemical binding]; other site 266264016973 oxyanion hole (OAH) forming residues; other site 266264016974 trimer interface [polypeptide binding]; other site 266264016975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016976 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264016977 enoyl-CoA hydratase; Provisional; Region: PRK06142 266264016978 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016979 substrate binding site [chemical binding]; other site 266264016980 oxyanion hole (OAH) forming residues; other site 266264016981 trimer interface [polypeptide binding]; other site 266264016982 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264016983 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264016984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264016985 potential protein location (hypothetical protein) that overlaps protein ( transcriptional regulator, AraC family) 266264016986 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266264016987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016988 NAD(P) binding site [chemical binding]; other site 266264016989 active site 266264016990 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264016991 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 266264016992 NAD(P) binding site [chemical binding]; other site 266264016993 catalytic residues [active] 266264016994 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 266264016995 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266264016996 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266264016997 FMN-binding pocket [chemical binding]; other site 266264016998 flavin binding motif; other site 266264016999 phosphate binding motif [ion binding]; other site 266264017000 beta-alpha-beta structure motif; other site 266264017001 NAD binding pocket [chemical binding]; other site 266264017002 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264017003 catalytic loop [active] 266264017004 iron binding site [ion binding]; other site 266264017005 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 266264017006 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266264017007 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266264017008 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266264017009 Ligand binding site [chemical binding]; other site 266264017010 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266264017011 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264017012 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 266264017013 dimer interaction site [polypeptide binding]; other site 266264017014 substrate-binding tunnel; other site 266264017015 active site 266264017016 catalytic site [active] 266264017017 substrate binding site [chemical binding]; other site 266264017018 enoyl-CoA hydratase; Provisional; Region: PRK09245 266264017019 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017020 substrate binding site [chemical binding]; other site 266264017021 oxyanion hole (OAH) forming residues; other site 266264017022 trimer interface [polypeptide binding]; other site 266264017023 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 266264017024 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266264017025 putative active site [active] 266264017026 putative substrate binding site [chemical binding]; other site 266264017027 ATP binding site [chemical binding]; other site 266264017028 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264017029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264017030 NAD(P) binding site [chemical binding]; other site 266264017031 active site 266264017032 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017033 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017034 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266264017035 putative active site [active] 266264017036 putative substrate binding site [chemical binding]; other site 266264017037 ATP binding site [chemical binding]; other site 266264017038 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 266264017039 AMP-binding enzyme; Region: AMP-binding; cl15778 266264017040 AMP-binding enzyme; Region: AMP-binding; cl15778 266264017041 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264017042 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264017043 active site 266264017044 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264017045 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 266264017046 FAD binding site [chemical binding]; other site 266264017047 substrate binding site [chemical binding]; other site 266264017048 catalytic base [active] 266264017049 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264017050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264017051 DNA-binding site [nucleotide binding]; DNA binding site 266264017052 FCD domain; Region: FCD; cl11656 266264017053 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264017054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264017055 DNA-binding site [nucleotide binding]; DNA binding site 266264017056 FCD domain; Region: FCD; cl11656 266264017057 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 266264017058 putative FMN binding site [chemical binding]; other site 266264017059 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 266264017060 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264017061 FMN binding site [chemical binding]; other site 266264017062 substrate binding site [chemical binding]; other site 266264017063 putative catalytic residue [active] 266264017064 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017065 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017066 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266264017067 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264017068 active site 2 [active] 266264017069 active site 1 [active] 266264017070 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264017071 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264017072 active site 266264017073 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264017074 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264017075 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264017076 active site 266264017077 putative transposase OrfB; Reviewed; Region: PHA02517 266264017078 HTH-like domain; Region: HTH_21; pfam13276 266264017079 Integrase core domain; Region: rve; cl01316 266264017080 Integrase core domain; Region: rve_3; cl15866 266264017081 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017082 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017083 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264017084 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 266264017085 NAD(P) binding site [chemical binding]; other site 266264017086 catalytic residues [active] 266264017087 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 266264017088 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266264017089 putative NAD(P) binding site [chemical binding]; other site 266264017090 catalytic Zn binding site [ion binding]; other site 266264017091 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266264017092 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266264017093 iron-sulfur cluster [ion binding]; other site 266264017094 [2Fe-2S] cluster binding site [ion binding]; other site 266264017095 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 266264017096 alpha subunit interface [polypeptide binding]; other site 266264017097 active site 266264017098 substrate binding site [chemical binding]; other site 266264017099 Fe binding site [ion binding]; other site 266264017100 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264017101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264017102 DNA binding residues [nucleotide binding] 266264017103 dimerization interface [polypeptide binding]; other site 266264017104 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 266264017105 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266264017106 hydrophobic ligand binding site; other site 266264017107 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266264017108 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266264017109 FMN-binding pocket [chemical binding]; other site 266264017110 flavin binding motif; other site 266264017111 phosphate binding motif [ion binding]; other site 266264017112 beta-alpha-beta structure motif; other site 266264017113 NAD binding pocket [chemical binding]; other site 266264017114 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264017115 catalytic loop [active] 266264017116 iron binding site [ion binding]; other site 266264017117 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264017118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264017119 DNA-binding site [nucleotide binding]; DNA binding site 266264017120 FCD domain; Region: FCD; cl11656 266264017121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264017122 NMT1-like family; Region: NMT1_2; cl15260 266264017123 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017124 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017125 lipid-transfer protein; Provisional; Region: PRK07855 266264017126 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264017127 active site 266264017128 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264017129 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264017130 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 266264017131 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017132 enoyl-CoA hydratase; Provisional; Region: PRK09245 266264017133 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017134 substrate binding site [chemical binding]; other site 266264017135 oxyanion hole (OAH) forming residues; other site 266264017136 trimer interface [polypeptide binding]; other site 266264017137 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 266264017138 Restriction endonuclease; Region: Mrr_cat; cl00516 266264017139 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266264017140 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 266264017141 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 266264017142 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 266264017143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266264017144 H-NS histone family; Region: Histone_HNS; pfam00816 266264017145 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 266264017146 AAA domain; Region: AAA_13; pfam13166 266264017147 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264017148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264017149 putative DNA binding site [nucleotide binding]; other site 266264017150 putative Zn2+ binding site [ion binding]; other site 266264017151 LysR family transcriptional regulator; Provisional; Region: PRK14997 266264017152 Helix-turn-helix domains; Region: HTH; cl00088 266264017153 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264017154 putative effector binding pocket; other site 266264017155 dimerization interface [polypeptide binding]; other site 266264017156 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 266264017157 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264017158 Helix-turn-helix domains; Region: HTH; cl00088 266264017159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264017160 dimerization interface [polypeptide binding]; other site 266264017161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264017162 NMT1-like family; Region: NMT1_2; cl15260 266264017163 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 266264017164 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 266264017165 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264017166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264017167 homodimer interface [polypeptide binding]; other site 266264017168 catalytic residue [active] 266264017169 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 266264017170 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 266264017171 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266264017172 Riboswitch candidate 266264017173 Riboswitch candidate 266264017174 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 266264017175 PAS fold; Region: PAS_4; pfam08448 266264017176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264017177 metal binding site [ion binding]; metal-binding site 266264017178 active site 266264017179 I-site; other site 266264017180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017181 putative substrate translocation pore; other site 266264017182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264017183 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264017184 Helix-turn-helix domains; Region: HTH; cl00088 266264017185 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264017186 dimerization interface [polypeptide binding]; other site 266264017187 substrate binding pocket [chemical binding]; other site 266264017188 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 266264017189 PLD-like domain; Region: PLDc_2; pfam13091 266264017190 putative active site [active] 266264017191 catalytic site [active] 266264017192 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 266264017193 PLD-like domain; Region: PLDc_2; pfam13091 266264017194 putative active site [active] 266264017195 catalytic site [active] 266264017196 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264017197 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264017198 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264017199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017200 putative substrate translocation pore; other site 266264017201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017202 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266264017203 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264017204 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264017205 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 266264017206 Helix-turn-helix domains; Region: HTH; cl00088 266264017207 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 266264017208 MltA-interacting protein MipA; Region: MipA; cl01504 266264017209 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 266264017210 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 266264017211 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 266264017212 tetramer interface [polypeptide binding]; other site 266264017213 heme binding pocket [chemical binding]; other site 266264017214 NADPH binding site [chemical binding]; other site 266264017215 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 266264017216 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266264017217 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266264017218 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264017219 classical (c) SDRs; Region: SDR_c; cd05233 266264017220 NAD(P) binding site [chemical binding]; other site 266264017221 active site 266264017222 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266264017223 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266264017224 tetramer interface [polypeptide binding]; other site 266264017225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264017226 catalytic residue [active] 266264017227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264017228 PAS domain; Region: PAS_9; pfam13426 266264017229 putative active site [active] 266264017230 heme pocket [chemical binding]; other site 266264017231 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264017232 metal binding site [ion binding]; metal-binding site 266264017233 active site 266264017234 I-site; other site 266264017235 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264017236 HDOD domain; Region: HDOD; pfam08668 266264017237 GAF domain; Region: GAF_2; pfam13185 266264017238 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 266264017239 active site clefts [active] 266264017240 zinc binding site [ion binding]; other site 266264017241 dimer interface [polypeptide binding]; other site 266264017242 Helix-turn-helix domains; Region: HTH; cl00088 266264017243 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 266264017244 dimerization interface [polypeptide binding]; other site 266264017245 metabolite-proton symporter; Region: 2A0106; TIGR00883 266264017246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017247 putative substrate translocation pore; other site 266264017248 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 266264017249 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264017250 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 266264017251 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266264017252 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266264017253 D-pathway; other site 266264017254 Putative ubiquinol binding site [chemical binding]; other site 266264017255 Low-spin heme (heme b) binding site [chemical binding]; other site 266264017256 Putative water exit pathway; other site 266264017257 Binuclear center (heme o3/CuB) [ion binding]; other site 266264017258 K-pathway; other site 266264017259 Putative proton exit pathway; other site 266264017260 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 266264017261 Subunit I/III interface [polypeptide binding]; other site 266264017262 Subunit III/IV interface [polypeptide binding]; other site 266264017263 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 266264017264 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264017265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264017266 dimerization interface [polypeptide binding]; other site 266264017267 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264017268 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264017269 dimer interface [polypeptide binding]; other site 266264017270 putative CheW interface [polypeptide binding]; other site 266264017271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264017273 putative substrate translocation pore; other site 266264017274 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 266264017275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264017276 NMT1-like family; Region: NMT1_2; cl15260 266264017277 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266264017278 active site lid residues [active] 266264017279 substrate binding pocket [chemical binding]; other site 266264017280 catalytic residues [active] 266264017281 substrate-Mg2+ binding site; other site 266264017282 aspartate-rich region 1; other site 266264017283 aspartate-rich region 2; other site 266264017284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266264017285 active site 266264017286 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264017287 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 266264017288 Haemolysin-III related; Region: HlyIII; cl03831 266264017289 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017290 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017291 enoyl-CoA hydratase; Provisional; Region: PRK06127 266264017292 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017293 substrate binding site [chemical binding]; other site 266264017294 oxyanion hole (OAH) forming residues; other site 266264017295 trimer interface [polypeptide binding]; other site 266264017296 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266264017297 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266264017298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264017299 NMT1-like family; Region: NMT1_2; cl15260 266264017300 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 266264017301 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 266264017302 homodimer interface [polypeptide binding]; other site 266264017303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264017304 catalytic residue [active] 266264017305 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264017306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264017307 DNA-binding site [nucleotide binding]; DNA binding site 266264017308 FCD domain; Region: FCD; cl11656 266264017309 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264017310 FAD binding domain; Region: FAD_binding_4; pfam01565 266264017311 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 266264017312 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 266264017313 aromatic amino acid exporter; Provisional; Region: PRK11689 266264017314 potential protein location (hypothetical protein) that overlaps protein (conserved hypothetical protein) 266264017315 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 266264017316 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266264017317 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 266264017318 active site 266264017319 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266264017320 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 266264017321 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266264017322 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 266264017323 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 266264017324 FAD binding pocket [chemical binding]; other site 266264017325 FAD binding motif [chemical binding]; other site 266264017326 catalytic residues [active] 266264017327 NAD binding pocket [chemical binding]; other site 266264017328 phosphate binding motif [ion binding]; other site 266264017329 beta-alpha-beta structure motif; other site 266264017330 ApbE family; Region: ApbE; cl00643 266264017331 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 266264017332 FlgD Ig-like domain; Region: FlgD_ig; cl15790 266264017333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 266264017334 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 266264017335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 266264017336 Cache domain; Region: Cache_2; cl07034 266264017337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264017338 dimer interface [polypeptide binding]; other site 266264017339 putative CheW interface [polypeptide binding]; other site 266264017340 flagellar capping protein; Reviewed; Region: fliD; PRK08032 266264017341 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 266264017342 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 266264017343 Helix-turn-helix domains; Region: HTH; cl00088 266264017344 WHG domain; Region: WHG; pfam13305 266264017345 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 266264017346 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 266264017347 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 266264017348 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266264017349 tetramer interface [polypeptide binding]; other site 266264017350 catalytic Zn binding site [ion binding]; other site 266264017351 NADP binding site [chemical binding]; other site 266264017352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264017353 DNA binding residues [nucleotide binding] 266264017354 dimerization interface [polypeptide binding]; other site 266264017355 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264017356 Ligand Binding Site [chemical binding]; other site 266264017357 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264017358 Helix-turn-helix domains; Region: HTH; cl00088 266264017359 AsnC family; Region: AsnC_trans_reg; pfam01037 266264017360 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 266264017361 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264017362 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266264017363 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266264017364 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264017365 putative chaperone; Provisional; Region: PRK11678 266264017366 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264017367 metal binding site [ion binding]; metal-binding site 266264017368 active site 266264017369 I-site; other site 266264017370 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 266264017371 catalytic triad [active] 266264017372 conserved cis-peptide bond; other site 266264017373 FOG: CBS domain [General function prediction only]; Region: COG0517 266264017374 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 266264017375 FOG: CBS domain [General function prediction only]; Region: COG0517 266264017376 FOG: CBS domain [General function prediction only]; Region: COG0517 266264017377 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 266264017378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264017379 PAS domain; Region: PAS_9; pfam13426 266264017380 putative active site [active] 266264017381 heme pocket [chemical binding]; other site 266264017382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264017383 metal binding site [ion binding]; metal-binding site 266264017384 active site 266264017385 I-site; other site 266264017386 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264017387 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264017388 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 266264017389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264017390 NAD(P) binding site [chemical binding]; other site 266264017391 active site 266264017392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264017393 Helix-turn-helix domains; Region: HTH; cl00088 266264017394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264017395 dimerization interface [polypeptide binding]; other site 266264017396 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 266264017397 Short C-terminal domain; Region: SHOCT; cl01373 266264017398 Copper resistance protein D; Region: CopD; cl00563 266264017399 Bacterial Ig-like domain; Region: Big_5; cl01012 266264017400 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 266264017401 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 266264017402 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264017403 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264017404 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264017405 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 266264017406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017407 active site 266264017408 phosphorylation site [posttranslational modification] 266264017409 intermolecular recognition site; other site 266264017410 dimerization interface [polypeptide binding]; other site 266264017411 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264017412 DNA binding site [nucleotide binding] 266264017413 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264017414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264017415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264017416 dimer interface [polypeptide binding]; other site 266264017417 phosphorylation site [posttranslational modification] 266264017418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264017419 ATP binding site [chemical binding]; other site 266264017420 Mg2+ binding site [ion binding]; other site 266264017421 G-X-G motif; other site 266264017422 Predicted transporter component [General function prediction only]; Region: COG2391 266264017423 Sulphur transport; Region: Sulf_transp; cl01018 266264017424 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 266264017425 Predicted transporter component [General function prediction only]; Region: COG2391 266264017426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264017427 dimerization interface [polypeptide binding]; other site 266264017428 putative DNA binding site [nucleotide binding]; other site 266264017429 putative Zn2+ binding site [ion binding]; other site 266264017430 heavy metal cation tricomponent efflux pump (fragment) 266264017431 putative transposase OrfB; Reviewed; Region: PHA02517 266264017432 HTH-like domain; Region: HTH_21; pfam13276 266264017433 Integrase core domain; Region: rve; cl01316 266264017434 Integrase core domain; Region: rve_3; cl15866 266264017435 Helix-turn-helix domains; Region: HTH; cl00088 266264017436 heavy metal cation tricomponent efflux pump (fragment) 266264017437 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264017438 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266264017439 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 266264017440 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 266264017441 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 266264017442 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 266264017443 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 266264017444 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 266264017445 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 266264017446 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266264017447 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 266264017448 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264017449 extra-cytoplasmic solute receptor protein (fragment) 266264017450 Protein of unknown function (DUF465); Region: DUF465; cl01070 266264017451 TolB amino-terminal domain; Region: TolB_N; cl00639 266264017452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 266264017453 intermolecular recognition site; other site 266264017454 active site 266264017455 dimerization interface [polypeptide binding]; other site 266264017456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264017457 DNA binding site [nucleotide binding] 266264017458 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 266264017459 amphipathic channel; other site 266264017460 Asn-Pro-Ala signature motifs; other site 266264017461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264017462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017463 active site 266264017464 phosphorylation site [posttranslational modification] 266264017465 intermolecular recognition site; other site 266264017466 dimerization interface [polypeptide binding]; other site 266264017467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264017468 DNA binding site [nucleotide binding] 266264017469 outer membrane protein OmpA (fragment) 266264017470 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 266264017471 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264017472 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264017473 substrate binding pocket [chemical binding]; other site 266264017474 membrane-bound complex binding site; other site 266264017475 hinge residues; other site 266264017476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264017477 substrate binding pocket [chemical binding]; other site 266264017478 membrane-bound complex binding site; other site 266264017479 hinge residues; other site 266264017480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264017481 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266264017482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264017483 dimer interface [polypeptide binding]; other site 266264017484 phosphorylation site [posttranslational modification] 266264017485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264017486 ATP binding site [chemical binding]; other site 266264017487 Mg2+ binding site [ion binding]; other site 266264017488 G-X-G motif; other site 266264017489 Response regulator receiver domain; Region: Response_reg; pfam00072 266264017490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017491 active site 266264017492 phosphorylation site [posttranslational modification] 266264017493 intermolecular recognition site; other site 266264017494 dimerization interface [polypeptide binding]; other site 266264017495 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 266264017496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264017497 binding surface 266264017498 TPR motif; other site 266264017499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264017500 binding surface 266264017501 TPR motif; other site 266264017502 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 266264017503 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264017504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017505 active site 266264017506 phosphorylation site [posttranslational modification] 266264017507 intermolecular recognition site; other site 266264017508 dimerization interface [polypeptide binding]; other site 266264017509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264017510 DNA binding residues [nucleotide binding] 266264017511 dimerization interface [polypeptide binding]; other site 266264017512 serine protease protein (fragment) 266264017513 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264017514 Helix-turn-helix domains; Region: HTH; cl00088 266264017515 Integrase core domain; Region: rve; cl01316 266264017516 Extracellular protease precursor (fragment) 266264017517 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264017518 trimer interface [polypeptide binding]; other site 266264017519 eyelet of channel; other site 266264017520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264017521 non-specific DNA binding site [nucleotide binding]; other site 266264017522 salt bridge; other site 266264017523 sequence-specific DNA binding site [nucleotide binding]; other site 266264017524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264017525 PAS domain; Region: PAS_9; pfam13426 266264017526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264017527 dimer interface [polypeptide binding]; other site 266264017528 phosphorylation site [posttranslational modification] 266264017529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264017530 ATP binding site [chemical binding]; other site 266264017531 Mg2+ binding site [ion binding]; other site 266264017532 G-X-G motif; other site 266264017533 Response regulator receiver domain; Region: Response_reg; pfam00072 266264017534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017535 active site 266264017536 phosphorylation site [posttranslational modification] 266264017537 intermolecular recognition site; other site 266264017538 dimerization interface [polypeptide binding]; other site 266264017539 Right handed beta helix region; Region: Beta_helix; pfam13229 266264017540 Right handed beta helix region; Region: Beta_helix; pfam13229 266264017541 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266264017542 putative trimer interface [polypeptide binding]; other site 266264017543 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266264017544 trimer interface [polypeptide binding]; other site 266264017545 active site 266264017546 substrate binding site [chemical binding]; other site 266264017547 CoA binding site [chemical binding]; other site 266264017548 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 266264017549 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266264017550 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 266264017551 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266264017552 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: GCD2; COG1184 266264017553 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 266264017554 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266264017555 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 266264017556 Walker A/P-loop; other site 266264017557 ATP binding site [chemical binding]; other site 266264017558 Q-loop/lid; other site 266264017559 ABC transporter signature motif; other site 266264017560 Walker B; other site 266264017561 D-loop; other site 266264017562 H-loop/switch region; other site 266264017563 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266264017564 NeuB family; Region: NeuB; cl00496 266264017565 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266264017566 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 266264017567 Ligand binding site; other site 266264017568 oligomer interface; other site 266264017569 KpsF/GutQ family protein; Region: kpsF; TIGR00393 266264017570 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 266264017571 putative active site [active] 266264017572 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 266264017573 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 266264017574 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 266264017575 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 266264017576 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 266264017577 active site 266264017578 catalytic triad [active] 266264017579 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266264017580 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266264017581 AMP-binding enzyme; Region: AMP-binding; cl15778 266264017582 AMP-binding enzyme; Region: AMP-binding; cl15778 266264017583 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266264017584 metal binding site 2 [ion binding]; metal-binding site 266264017585 putative DNA binding helix; other site 266264017586 metal binding site 1 [ion binding]; metal-binding site 266264017587 dimer interface [polypeptide binding]; other site 266264017588 structural Zn2+ binding site [ion binding]; other site 266264017589 EamA-like transporter family; Region: EamA; cl01037 266264017590 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266264017591 EamA-like transporter family; Region: EamA; cl01037 266264017592 Helix-turn-helix domains; Region: HTH; cl00088 266264017593 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264017594 metal binding site [ion binding]; metal-binding site 266264017595 active site 266264017596 I-site; other site 266264017597 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264017598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264017599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264017600 PAS fold; Region: PAS_4; pfam08448 266264017601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264017602 metal binding site [ion binding]; metal-binding site 266264017603 active site 266264017604 I-site; other site 266264017605 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 266264017606 dimerization interface [polypeptide binding]; other site 266264017607 fumarate hydratase (fumarase C),aerobic Class II (fragment) 266264017608 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264017609 Helix-turn-helix domains; Region: HTH; cl00088 266264017610 Integrase core domain; Region: rve; cl01316 266264017611 fumarate hydratase (fumarase C),aerobic Class II 266264017612 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264017613 trimer interface [polypeptide binding]; other site 266264017614 eyelet of channel; other site 266264017615 citrate-proton symporter; Provisional; Region: PRK15075 266264017616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017617 putative substrate translocation pore; other site 266264017618 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 266264017619 putative active site [active] 266264017620 Zn binding site [ion binding]; other site 266264017621 Peptidase C26; Region: Peptidase_C26; pfam07722 266264017622 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266264017623 catalytic triad [active] 266264017624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264017625 Helix-turn-helix domains; Region: HTH; cl00088 266264017626 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264017627 dimerization interface [polypeptide binding]; other site 266264017628 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264017629 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264017630 ligand binding site [chemical binding]; other site 266264017631 flexible hinge region; other site 266264017632 Helix-turn-helix domains; Region: HTH; cl00088 266264017633 acyl-CoA synthetase; Validated; Region: PRK08162 266264017634 AMP-binding enzyme; Region: AMP-binding; cl15778 266264017635 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264017636 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266264017637 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 266264017638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264017639 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266264017640 enoyl-CoA hydratase; Provisional; Region: PRK06688 266264017641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017642 substrate binding site [chemical binding]; other site 266264017643 oxyanion hole (OAH) forming residues; other site 266264017644 trimer interface [polypeptide binding]; other site 266264017645 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266264017646 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264017647 Helix-turn-helix domains; Region: HTH; cl00088 266264017648 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 266264017649 Cupin domain; Region: Cupin_2; cl09118 266264017650 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264017651 trimer interface [polypeptide binding]; other site 266264017652 eyelet of channel; other site 266264017653 CCC1-related family of proteins; Region: CCC1_like; cl00278 266264017654 Protein of unknown function, DUF485; Region: DUF485; cl01231 266264017655 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 266264017656 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 266264017657 Na binding site [ion binding]; other site 266264017658 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266264017659 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266264017660 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 266264017661 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 266264017662 catalytic residues [active] 266264017663 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 266264017664 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 266264017665 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 266264017666 Subunit I/III interface [polypeptide binding]; other site 266264017667 Subunit III/IV interface [polypeptide binding]; other site 266264017668 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266264017669 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266264017670 D-pathway; other site 266264017671 Putative ubiquinol binding site [chemical binding]; other site 266264017672 Low-spin heme (heme b) binding site [chemical binding]; other site 266264017673 Putative water exit pathway; other site 266264017674 Binuclear center (heme o3/CuB) [ion binding]; other site 266264017675 K-pathway; other site 266264017676 Putative proton exit pathway; other site 266264017677 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 266264017678 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266264017679 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 266264017680 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264017681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264017682 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264017683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264017684 homodimer interface [polypeptide binding]; other site 266264017685 catalytic residue [active] 266264017686 OPT oligopeptide transporter protein; Region: OPT; cl14607 266264017687 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266264017688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264017689 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264017690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266264017691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264017692 ATP binding site [chemical binding]; other site 266264017693 Mg2+ binding site [ion binding]; other site 266264017694 G-X-G motif; other site 266264017695 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 266264017696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017697 active site 266264017698 phosphorylation site [posttranslational modification] 266264017699 intermolecular recognition site; other site 266264017700 dimerization interface [polypeptide binding]; other site 266264017701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264017702 DNA binding site [nucleotide binding] 266264017703 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266264017704 glucokinase, proteobacterial type; Region: glk; TIGR00749 266264017705 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 266264017706 putative active site [active] 266264017707 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 266264017708 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266264017709 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266264017710 Dehydratase family; Region: ILVD_EDD; cl00340 266264017711 6-phosphogluconate dehydratase; Region: edd; TIGR01196 266264017712 mechanosensitive channel MscS; Provisional; Region: PRK10334 266264017713 Conserved TM helix; Region: TM_helix; pfam05552 266264017714 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264017715 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264017716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264017717 H+ Antiporter protein; Region: 2A0121; TIGR00900 266264017718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017719 putative substrate translocation pore; other site 266264017720 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 266264017721 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264017722 N-terminal plug; other site 266264017723 ligand-binding site [chemical binding]; other site 266264017724 hypothetical protein 266264017725 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 266264017726 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264017727 N-terminal plug; other site 266264017728 ligand-binding site [chemical binding]; other site 266264017729 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 266264017730 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 266264017731 G1 box; other site 266264017732 putative GEF interaction site [polypeptide binding]; other site 266264017733 GTP/Mg2+ binding site [chemical binding]; other site 266264017734 Switch I region; other site 266264017735 G2 box; other site 266264017736 G3 box; other site 266264017737 Switch II region; other site 266264017738 G4 box; other site 266264017739 G5 box; other site 266264017740 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 266264017741 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 266264017742 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264017743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264017744 Walker A motif; other site 266264017745 ATP binding site [chemical binding]; other site 266264017746 Walker B motif; other site 266264017747 arginine finger; other site 266264017748 Helix-turn-helix domains; Region: HTH; cl00088 266264017749 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 266264017750 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266264017751 DNA-binding site [nucleotide binding]; DNA binding site 266264017752 RNA-binding motif; other site