-- dump date 20120504_143051 -- class Genbank::misc_feature -- table misc_feature_note -- id note 65393000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 65393000002 hypothetical protein; Validated; Region: PRK06672 65393000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393000004 Walker A motif; other site 65393000005 ATP binding site [chemical binding]; other site 65393000006 Walker B motif; other site 65393000007 arginine finger; other site 65393000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 65393000009 DnaA box-binding interface [nucleotide binding]; other site 65393000010 UbiA prenyltransferase family; Region: UbiA; cl00337 65393000011 tocopherol cyclase; Region: PLN02818 65393000012 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 65393000013 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 65393000014 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 65393000015 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393000016 putative active site [active] 65393000017 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 65393000018 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 65393000019 Walker A/P-loop; other site 65393000020 ATP binding site [chemical binding]; other site 65393000021 Q-loop/lid; other site 65393000022 ABC transporter signature motif; other site 65393000023 Walker B; other site 65393000024 D-loop; other site 65393000025 H-loop/switch region; other site 65393000026 DevC protein; Region: devC; TIGR01185 65393000027 FtsX-like permease family; Region: FtsX; pfam02687 65393000028 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 65393000029 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 65393000030 lipoyl-biotinyl attachment site [posttranslational modification]; other site 65393000031 Clp protease ATP binding subunit; Region: clpC; CHL00095 65393000032 Clp amino terminal domain; Region: Clp_N; pfam02861 65393000033 Clp amino terminal domain; Region: Clp_N; pfam02861 65393000034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393000035 Walker A motif; other site 65393000036 ATP binding site [chemical binding]; other site 65393000037 Walker B motif; other site 65393000038 arginine finger; other site 65393000039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393000040 Walker A motif; other site 65393000041 ATP binding site [chemical binding]; other site 65393000042 Walker B motif; other site 65393000043 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 65393000044 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 65393000045 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 65393000046 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 65393000047 putative active site [active] 65393000048 putative substrate binding site [chemical binding]; other site 65393000049 putative cosubstrate binding site; other site 65393000050 catalytic site [active] 65393000051 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393000052 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393000053 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 65393000054 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393000055 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 65393000056 protein binding site [polypeptide binding]; other site 65393000057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393000058 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 65393000059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393000060 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 65393000061 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 65393000062 Probable Catalytic site; other site 65393000063 metal-binding site 65393000064 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 65393000065 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 65393000066 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 65393000067 Ligand binding site; other site 65393000068 Putative Catalytic site; other site 65393000069 DXD motif; other site 65393000070 Predicted integral membrane protein [Function unknown]; Region: COG0392 65393000071 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 65393000072 Probable Catalytic site; other site 65393000073 metal-binding site 65393000074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393000075 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393000076 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393000077 active site 65393000078 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 65393000079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393000080 NAD(P) binding site [chemical binding]; other site 65393000081 active site 65393000082 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 65393000083 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 65393000084 active site 65393000085 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 65393000086 feedback inhibition sensing region; other site 65393000087 homohexameric interface [polypeptide binding]; other site 65393000088 nucleotide binding site [chemical binding]; other site 65393000089 N-acetyl-L-glutamate binding site [chemical binding]; other site 65393000090 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 65393000091 oxyanion hole [active] 65393000092 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 65393000093 Low molecular weight phosphatase family; Region: LMWPc; cd00115 65393000094 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 65393000095 active site 65393000096 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 65393000097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393000098 active site 65393000099 phosphorylation site [posttranslational modification] 65393000100 intermolecular recognition site; other site 65393000101 dimerization interface [polypeptide binding]; other site 65393000102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393000103 DNA binding residues [nucleotide binding] 65393000104 dimerization interface [polypeptide binding]; other site 65393000105 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 65393000106 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393000107 ATP binding site [chemical binding]; other site 65393000108 putative Mg++ binding site [ion binding]; other site 65393000109 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 65393000110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393000111 nucleotide binding region [chemical binding]; other site 65393000112 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 65393000113 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 65393000114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393000115 GAF domain; Region: GAF; cl00853 65393000116 Phytochrome region; Region: PHY; pfam00360 65393000117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393000118 dimer interface [polypeptide binding]; other site 65393000119 phosphorylation site [posttranslational modification] 65393000120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393000121 ATP binding site [chemical binding]; other site 65393000122 Mg2+ binding site [ion binding]; other site 65393000123 G-X-G motif; other site 65393000124 Response regulator receiver domain; Region: Response_reg; pfam00072 65393000125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393000126 active site 65393000127 phosphorylation site [posttranslational modification] 65393000128 intermolecular recognition site; other site 65393000129 dimerization interface [polypeptide binding]; other site 65393000130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393000131 active site 65393000132 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 65393000133 phosphorylation site [posttranslational modification] 65393000134 intermolecular recognition site; other site 65393000135 dimerization interface [polypeptide binding]; other site 65393000136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393000137 dimer interface [polypeptide binding]; other site 65393000138 phosphorylation site [posttranslational modification] 65393000139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393000140 ATP binding site [chemical binding]; other site 65393000141 Mg2+ binding site [ion binding]; other site 65393000142 G-X-G motif; other site 65393000143 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 65393000144 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 65393000145 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 65393000146 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 65393000147 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 65393000148 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393000149 catalytic residue [active] 65393000150 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 65393000151 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 65393000152 homodimer interface [polypeptide binding]; other site 65393000153 oligonucleotide binding site [chemical binding]; other site 65393000154 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 65393000155 RNA/DNA hybrid binding site [nucleotide binding]; other site 65393000156 active site 65393000157 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 65393000158 prephenate dehydratase; Provisional; Region: PRK11898 65393000159 Prephenate dehydratase; Region: PDT; pfam00800 65393000160 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 65393000161 putative L-Phe binding site [chemical binding]; other site 65393000162 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 65393000163 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 65393000164 elongation factor Tu; Region: tufA; CHL00071 65393000165 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 65393000166 G1 box; other site 65393000167 GEF interaction site [polypeptide binding]; other site 65393000168 GTP/Mg2+ binding site [chemical binding]; other site 65393000169 Switch I region; other site 65393000170 G2 box; other site 65393000171 G3 box; other site 65393000172 Switch II region; other site 65393000173 G4 box; other site 65393000174 G5 box; other site 65393000175 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 65393000176 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 65393000177 Antibiotic Binding Site [chemical binding]; other site 65393000178 elongation factor G; Reviewed; Region: PRK00007 65393000179 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 65393000180 G1 box; other site 65393000181 putative GEF interaction site [polypeptide binding]; other site 65393000182 GTP/Mg2+ binding site [chemical binding]; other site 65393000183 Switch I region; other site 65393000184 G2 box; other site 65393000185 G3 box; other site 65393000186 Switch II region; other site 65393000187 G4 box; other site 65393000188 G5 box; other site 65393000189 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 65393000190 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 65393000191 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 65393000192 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 65393000193 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 65393000194 S17 interaction site [polypeptide binding]; other site 65393000195 S8 interaction site; other site 65393000196 16S rRNA interaction site [nucleotide binding]; other site 65393000197 streptomycin interaction site [chemical binding]; other site 65393000198 23S rRNA interaction site [nucleotide binding]; other site 65393000199 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 65393000200 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 65393000201 Cupin domain; Region: Cupin_2; cl09118 65393000202 Probable transposase; Region: OrfB_IS605; pfam01385 65393000203 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393000204 Permease family; Region: Xan_ur_permease; cl00967 65393000205 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 65393000206 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393000207 ligand binding site [chemical binding]; other site 65393000208 flexible hinge region; other site 65393000209 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 65393000210 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 65393000211 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 65393000212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 65393000213 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 65393000214 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 65393000215 Walker A/P-loop; other site 65393000216 ATP binding site [chemical binding]; other site 65393000217 Q-loop/lid; other site 65393000218 ABC transporter signature motif; other site 65393000219 Walker B; other site 65393000220 D-loop; other site 65393000221 H-loop/switch region; other site 65393000222 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 65393000223 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 65393000224 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 65393000225 Ligand binding site; other site 65393000226 Putative Catalytic site; other site 65393000227 DXD motif; other site 65393000228 hydrolase, alpha/beta fold family protein; Region: PLN02824 65393000229 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 65393000230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393000231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393000232 active site 65393000233 ATP binding site [chemical binding]; other site 65393000234 substrate binding site [chemical binding]; other site 65393000235 activation loop (A-loop); other site 65393000236 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 65393000237 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393000238 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393000239 structural tetrad; other site 65393000240 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393000241 structural tetrad; other site 65393000242 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 65393000243 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 65393000244 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 65393000245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393000246 Walker A/P-loop; other site 65393000247 ATP binding site [chemical binding]; other site 65393000248 Q-loop/lid; other site 65393000249 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 65393000250 ABC transporter; Region: ABC_tran_2; pfam12848 65393000251 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 65393000252 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393000253 putative active site [active] 65393000254 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 65393000255 DNA photolyase; Region: DNA_photolyase; pfam00875 65393000256 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 65393000257 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393000258 putative active site [active] 65393000259 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 65393000260 dimer interface [polypeptide binding]; other site 65393000261 ADP-ribose binding site [chemical binding]; other site 65393000262 active site 65393000263 nudix motif; other site 65393000264 metal binding site [ion binding]; metal-binding site 65393000265 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 65393000266 catalytic center binding site [active] 65393000267 ATP binding site [chemical binding]; other site 65393000268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393000269 ATP binding site [chemical binding]; other site 65393000270 putative Mg++ binding site [ion binding]; other site 65393000271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393000272 nucleotide binding region [chemical binding]; other site 65393000273 ATP-binding site [chemical binding]; other site 65393000274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 65393000275 Transposase; Region: DDE_Tnp_ISL3; pfam01610 65393000276 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393000277 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 65393000278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 65393000279 phosphoglycolate phosphatase; Provisional; Region: PRK01158 65393000280 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393000281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393000282 Probable transposase; Region: OrfB_IS605; pfam01385 65393000283 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393000284 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 65393000285 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 65393000286 dimer interface [polypeptide binding]; other site 65393000287 decamer (pentamer of dimers) interface [polypeptide binding]; other site 65393000288 catalytic triad [active] 65393000289 peroxidatic and resolving cysteines [active] 65393000290 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 65393000291 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 65393000292 active site 65393000293 substrate binding site [chemical binding]; other site 65393000294 catalytic site [active] 65393000295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393000296 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 65393000297 Walker A motif; other site 65393000298 ATP binding site [chemical binding]; other site 65393000299 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393000300 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 65393000301 putative acyl-acceptor binding pocket; other site 65393000302 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 65393000303 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 65393000304 active site 65393000305 HIGH motif; other site 65393000306 KMSKS motif; other site 65393000307 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 65393000308 tRNA binding surface [nucleotide binding]; other site 65393000309 anticodon binding site; other site 65393000310 Uncharacterized conserved protein [Function unknown]; Region: COG1432 65393000311 LabA_like proteins; Region: LabA; cd10911 65393000312 putative metal binding site [ion binding]; other site 65393000313 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 65393000314 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 65393000315 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393000316 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 65393000317 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 65393000318 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 65393000319 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 65393000320 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 65393000321 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 65393000322 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393000323 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 65393000324 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 65393000325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393000326 FeS/SAM binding site; other site 65393000327 TRAM domain; Region: TRAM; cl01282 65393000328 Photosystem I protein M (PsaM); Region: PsaM; cl15374 65393000329 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 65393000330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 65393000331 Transposase; Region: DDE_Tnp_ISL3; pfam01610 65393000332 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393000333 structural tetrad; other site 65393000334 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393000335 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393000336 structural tetrad; other site 65393000337 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 65393000338 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 65393000339 putative switch regulator; other site 65393000340 non-specific DNA interactions [nucleotide binding]; other site 65393000341 DNA binding site [nucleotide binding] 65393000342 sequence specific DNA binding site [nucleotide binding]; other site 65393000343 putative cAMP binding site [chemical binding]; other site 65393000344 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 65393000345 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 65393000346 metal-binding site [ion binding] 65393000347 PAS domain S-box; Region: sensory_box; TIGR00229 65393000348 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393000349 putative active site [active] 65393000350 heme pocket [chemical binding]; other site 65393000351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393000352 PAS fold; Region: PAS_4; pfam08448 65393000353 PAS fold; Region: PAS; pfam00989 65393000354 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393000355 putative active site [active] 65393000356 heme pocket [chemical binding]; other site 65393000357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393000358 PAS fold; Region: PAS_3; pfam08447 65393000359 putative active site [active] 65393000360 heme pocket [chemical binding]; other site 65393000361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393000362 PAS fold; Region: PAS_3; pfam08447 65393000363 putative active site [active] 65393000364 heme pocket [chemical binding]; other site 65393000365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393000366 PAS domain S-box; Region: sensory_box; TIGR00229 65393000367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393000368 PAS fold; Region: PAS_3; pfam08447 65393000369 putative active site [active] 65393000370 heme pocket [chemical binding]; other site 65393000371 PAS domain S-box; Region: sensory_box; TIGR00229 65393000372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393000373 putative active site [active] 65393000374 heme pocket [chemical binding]; other site 65393000375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393000376 dimer interface [polypeptide binding]; other site 65393000377 phosphorylation site [posttranslational modification] 65393000378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393000379 ATP binding site [chemical binding]; other site 65393000380 Mg2+ binding site [ion binding]; other site 65393000381 G-X-G motif; other site 65393000382 Response regulator receiver domain; Region: Response_reg; pfam00072 65393000383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393000384 active site 65393000385 phosphorylation site [posttranslational modification] 65393000386 intermolecular recognition site; other site 65393000387 dimerization interface [polypeptide binding]; other site 65393000388 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 65393000389 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 65393000390 active site 65393000391 catalytic triad [active] 65393000392 Predicted ATPase [General function prediction only]; Region: COG4637 65393000393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393000394 SOUL heme-binding protein; Region: SOUL; pfam04832 65393000395 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 65393000396 endonuclease III; Region: ENDO3c; smart00478 65393000397 minor groove reading motif; other site 65393000398 helix-hairpin-helix signature motif; other site 65393000399 substrate binding pocket [chemical binding]; other site 65393000400 active site 65393000401 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 65393000402 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 65393000403 active site 65393000404 metal binding site [ion binding]; metal-binding site 65393000405 interdomain interaction site; other site 65393000406 Virulence-associated protein E; Region: VirE; pfam05272 65393000407 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 65393000408 Phage integrase family; Region: Phage_integrase; pfam00589 65393000409 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 65393000410 DNA binding site [nucleotide binding] 65393000411 Int/Topo IB signature motif; other site 65393000412 active site 65393000413 catalytic residues [active] 65393000414 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 65393000415 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 65393000416 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 65393000417 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 65393000418 active site 65393000419 catalytic site [active] 65393000420 probable methyltransferase; Region: TIGR03438 65393000421 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 65393000422 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 65393000423 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 65393000424 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 65393000425 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 65393000426 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393000427 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 65393000428 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393000429 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 65393000430 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393000431 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 65393000432 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 65393000433 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 65393000434 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 65393000435 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 65393000436 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 65393000437 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 65393000438 Phycobilisome protein; Region: Phycobilisome; cl08227 65393000439 Phycobilisome protein; Region: Phycobilisome; cl08227 65393000440 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 65393000441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393000442 S-adenosylmethionine binding site [chemical binding]; other site 65393000443 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 65393000444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393000445 active site 65393000446 phosphorylation site [posttranslational modification] 65393000447 intermolecular recognition site; other site 65393000448 dimerization interface [polypeptide binding]; other site 65393000449 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393000450 DNA binding residues [nucleotide binding] 65393000451 dimerization interface [polypeptide binding]; other site 65393000452 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 65393000453 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 65393000454 NAD(P) binding site [chemical binding]; other site 65393000455 catalytic residues [active] 65393000456 hypothetical protein; Provisional; Region: PRK08185 65393000457 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 65393000458 intersubunit interface [polypeptide binding]; other site 65393000459 active site 65393000460 zinc binding site [ion binding]; other site 65393000461 Na+ binding site [ion binding]; other site 65393000462 Haemolysin XhlA; Region: XhlA; pfam10779 65393000463 tellurium resistance terB-like protein; Region: terB_like; cl11965 65393000464 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 65393000465 protein I interface; other site 65393000466 D2 interface; other site 65393000467 protein T interface; other site 65393000468 chlorophyll binding site; other site 65393000469 beta carotene binding site; other site 65393000470 pheophytin binding site; other site 65393000471 manganese-stabilizing polypeptide interface; other site 65393000472 CP43 interface; other site 65393000473 protein L interface; other site 65393000474 oxygen evolving complex binding site; other site 65393000475 bromide binding site; other site 65393000476 quinone binding site; other site 65393000477 Fe binding site [ion binding]; other site 65393000478 core light harvesting interface; other site 65393000479 cytochrome b559 alpha subunit interface; other site 65393000480 cytochrome c-550 interface; other site 65393000481 protein J interface; other site 65393000482 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393000483 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 65393000484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393000485 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393000486 Probable transposase; Region: OrfB_IS605; pfam01385 65393000487 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393000488 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393000489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393000490 binding surface 65393000491 TPR motif; other site 65393000492 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 65393000493 Amino acid permease; Region: AA_permease; cl00524 65393000494 Response regulator receiver domain; Region: Response_reg; pfam00072 65393000495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393000496 active site 65393000497 phosphorylation site [posttranslational modification] 65393000498 intermolecular recognition site; other site 65393000499 dimerization interface [polypeptide binding]; other site 65393000500 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393000501 metal binding site [ion binding]; metal-binding site 65393000502 active site 65393000503 I-site; other site 65393000504 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 65393000505 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 65393000506 substrate binding pocket [chemical binding]; other site 65393000507 membrane-bound complex binding site; other site 65393000508 hinge residues; other site 65393000509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393000510 binding surface 65393000511 TPR motif; other site 65393000512 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 65393000513 putative substrate binding pocket [chemical binding]; other site 65393000514 catalytic triad [active] 65393000515 AB domain interface; other site 65393000516 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 65393000517 dimerization interface [polypeptide binding]; other site 65393000518 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 65393000519 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 65393000520 active site 65393000521 NTP binding site [chemical binding]; other site 65393000522 metal binding triad [ion binding]; metal-binding site 65393000523 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 65393000524 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 65393000525 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 65393000526 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 65393000527 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 65393000528 Sporulation and spore germination; Region: Germane; cl11253 65393000529 EVE domain; Region: EVE; cl00728 65393000530 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 65393000531 homodimer interface [polypeptide binding]; other site 65393000532 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 65393000533 active site pocket [active] 65393000534 thiamine monophosphate kinase; Provisional; Region: PRK05731 65393000535 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 65393000536 ATP binding site [chemical binding]; other site 65393000537 dimerization interface [polypeptide binding]; other site 65393000538 Domain of unknown function (DUF1821); Region: DUF1821; pfam08851 65393000539 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 65393000540 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 65393000541 active site 65393000542 catalytic tetrad [active] 65393000543 alpha/beta hydrolase fold protein; Provisional; Region: PLN03084 65393000544 Oxygen evolving enhancer protein 3 (PsbQ); Region: PsbQ; cl05363 65393000545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393000546 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 65393000547 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 65393000548 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393000549 Response regulator receiver domain; Region: Response_reg; pfam00072 65393000550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393000551 active site 65393000552 phosphorylation site [posttranslational modification] 65393000553 intermolecular recognition site; other site 65393000554 dimerization interface [polypeptide binding]; other site 65393000555 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393000556 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393000557 active site 65393000558 ATP binding site [chemical binding]; other site 65393000559 substrate binding site [chemical binding]; other site 65393000560 activation loop (A-loop); other site 65393000561 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393000562 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393000563 active site 65393000564 ATP binding site [chemical binding]; other site 65393000565 substrate binding site [chemical binding]; other site 65393000566 activation loop (A-loop); other site 65393000567 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393000568 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393000569 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393000570 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 65393000571 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 65393000572 domain interfaces; other site 65393000573 active site 65393000574 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393000575 putative active site [active] 65393000576 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 65393000577 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 65393000578 Cl- selectivity filter; other site 65393000579 Cl- binding residues [ion binding]; other site 65393000580 pore gating glutamate residue; other site 65393000581 dimer interface [polypeptide binding]; other site 65393000582 H+/Cl- coupling transport residue; other site 65393000583 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 65393000584 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 65393000585 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 65393000586 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 65393000587 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393000588 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393000589 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 65393000590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393000591 NAD(P) binding site [chemical binding]; other site 65393000592 active site 65393000593 EcsC protein family; Region: EcsC; pfam12787 65393000594 putative lipid kinase; Reviewed; Region: PRK00861 65393000595 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 65393000596 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393000597 GTP-binding protein YchF; Reviewed; Region: PRK09601 65393000598 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 65393000599 G1 box; other site 65393000600 GTP/Mg2+ binding site [chemical binding]; other site 65393000601 Switch I region; other site 65393000602 G2 box; other site 65393000603 Switch II region; other site 65393000604 G3 box; other site 65393000605 G4 box; other site 65393000606 G5 box; other site 65393000607 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 65393000608 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 65393000609 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393000610 cytosine deaminase-like protein; Validated; Region: PRK07583 65393000611 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 65393000612 active site 65393000613 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 65393000614 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 65393000615 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 65393000616 tyrosine kinase; Provisional; Region: PRK11519 65393000617 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 65393000618 Nucleotide binding site [chemical binding]; other site 65393000619 DTAP/Switch II; other site 65393000620 Switch I; other site 65393000621 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 65393000622 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 65393000623 active site 65393000624 catalytic tetrad [active] 65393000625 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 65393000626 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 65393000627 Lumazine binding domain; Region: Lum_binding; pfam00677 65393000628 Lumazine binding domain; Region: Lum_binding; pfam00677 65393000629 Sulfatase; Region: Sulfatase; cl10460 65393000630 Sulfatase; Region: Sulfatase; cl10460 65393000631 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 65393000632 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393000633 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393000634 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393000635 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 65393000636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393000637 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 65393000638 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 65393000639 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 65393000640 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393000641 active site 65393000642 Protein of unknown function (DUF552); Region: DUF552; cl00775 65393000643 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 65393000644 putative FMN binding site [chemical binding]; other site 65393000645 NADPH bind site [chemical binding]; other site 65393000646 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 65393000647 putative FMN binding site [chemical binding]; other site 65393000648 NADPH bind site [chemical binding]; other site 65393000649 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393000650 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 65393000651 Protein of unknown function DUF86; Region: DUF86; cl01031 65393000652 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393000653 active site 65393000654 NTP binding site [chemical binding]; other site 65393000655 metal binding triad [ion binding]; metal-binding site 65393000656 antibiotic binding site [chemical binding]; other site 65393000657 Protein of unknown function (DUF433); Region: DUF433; cl01030 65393000658 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 65393000659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 65393000660 Protein of unknown function (DUF497); Region: DUF497; cl01108 65393000661 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 65393000662 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 65393000663 putative substrate binding site [chemical binding]; other site 65393000664 putative ATP binding site [chemical binding]; other site 65393000665 ADP-glucose phosphorylase; Region: PLN02643 65393000666 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 65393000667 nucleotide binding site/active site [active] 65393000668 HIT family signature motif; other site 65393000669 catalytic residue [active] 65393000670 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 65393000671 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 65393000672 generic binding surface II; other site 65393000673 generic binding surface I; other site 65393000674 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 65393000675 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393000676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393000677 S-adenosylmethionine binding site [chemical binding]; other site 65393000678 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 65393000679 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 65393000680 putative active site [active] 65393000681 putative metal binding site [ion binding]; other site 65393000682 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 65393000683 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 65393000684 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 65393000685 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 65393000686 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 65393000687 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 65393000688 Stage II sporulation protein; Region: SpoIID; pfam08486 65393000689 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 65393000690 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 65393000691 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 65393000692 inhibitor-cofactor binding pocket; inhibition site 65393000693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393000694 catalytic residue [active] 65393000695 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 65393000696 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 65393000697 homoserine dehydrogenase; Provisional; Region: PRK06349 65393000698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393000699 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 65393000700 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 65393000701 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 65393000702 Peptidase family M23; Region: Peptidase_M23; pfam01551 65393000703 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 65393000704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393000705 S-adenosylmethionine binding site [chemical binding]; other site 65393000706 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 65393000707 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 65393000708 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 65393000709 NAD synthetase; Provisional; Region: PRK13981 65393000710 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 65393000711 multimer interface [polypeptide binding]; other site 65393000712 active site 65393000713 catalytic triad [active] 65393000714 protein interface 1 [polypeptide binding]; other site 65393000715 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 65393000716 homodimer interface [polypeptide binding]; other site 65393000717 NAD binding pocket [chemical binding]; other site 65393000718 ATP binding pocket [chemical binding]; other site 65393000719 Mg binding site [ion binding]; other site 65393000720 active-site loop [active] 65393000721 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 65393000722 nudix motif; other site 65393000723 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 65393000724 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 65393000725 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 65393000726 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 65393000727 active site 65393000728 (T/H)XGH motif; other site 65393000729 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 65393000730 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 65393000731 active site 65393000732 Protein of unknown function DUF86; Region: DUF86; cl01031 65393000733 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393000734 active site 65393000735 NTP binding site [chemical binding]; other site 65393000736 metal binding triad [ion binding]; metal-binding site 65393000737 antibiotic binding site [chemical binding]; other site 65393000738 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 65393000739 Domain of unknown function (DUF389); Region: DUF389; cl00781 65393000740 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 65393000741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393000742 CoA-ligase; Region: Ligase_CoA; pfam00549 65393000743 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393000744 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 65393000745 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 65393000746 NADP binding site [chemical binding]; other site 65393000747 active site 65393000748 steroid binding site; other site 65393000749 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 65393000750 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 65393000751 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 65393000752 active site 65393000753 metal binding site [ion binding]; metal-binding site 65393000754 serine racemase; Region: PLN02970 65393000755 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 65393000756 tetramer interface [polypeptide binding]; other site 65393000757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393000758 catalytic residue [active] 65393000759 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 65393000760 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393000761 motif II; other site 65393000762 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 65393000763 intersubunit interface [polypeptide binding]; other site 65393000764 active site 65393000765 Zn2+ binding site [ion binding]; other site 65393000766 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 65393000767 dihydrodipicolinate reductase; Provisional; Region: PRK00048 65393000768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393000769 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 65393000770 Protein of unknown function (DUF429); Region: DUF429; cl12046 65393000771 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 65393000772 isocitrate dehydrogenase; Validated; Region: PRK07362 65393000773 Quinolinate synthetase A protein; Region: NadA; cl00420 65393000774 short chain dehydrogenase; Provisional; Region: PRK07063 65393000775 classical (c) SDRs; Region: SDR_c; cd05233 65393000776 NAD(P) binding site [chemical binding]; other site 65393000777 active site 65393000778 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 65393000779 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393000780 putative active site [active] 65393000781 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 65393000782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393000783 ATP binding site [chemical binding]; other site 65393000784 putative Mg++ binding site [ion binding]; other site 65393000785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393000786 nucleotide binding region [chemical binding]; other site 65393000787 ATP-binding site [chemical binding]; other site 65393000788 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 65393000789 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 65393000790 ABC-2 type transporter; Region: ABC2_membrane; cl11417 65393000791 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 65393000792 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 65393000793 Walker A/P-loop; other site 65393000794 ATP binding site [chemical binding]; other site 65393000795 Q-loop/lid; other site 65393000796 ABC transporter signature motif; other site 65393000797 Walker B; other site 65393000798 D-loop; other site 65393000799 H-loop/switch region; other site 65393000800 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 65393000801 putative carbohydrate binding site [chemical binding]; other site 65393000802 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393000803 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393000804 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 65393000805 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393000806 active site 65393000807 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393000808 active site 65393000809 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393000810 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 65393000811 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 65393000812 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 65393000813 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 65393000814 peptide binding site [polypeptide binding]; other site 65393000815 dimer interface [polypeptide binding]; other site 65393000816 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 65393000817 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 65393000818 putative ribose interaction site [chemical binding]; other site 65393000819 putative ADP binding site [chemical binding]; other site 65393000820 Gram-negative bacterial tonB protein; Region: TonB; cl10048 65393000821 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 65393000822 DNA polymerase III subunit beta; Validated; Region: PRK05643 65393000823 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 65393000824 putative DNA binding surface [nucleotide binding]; other site 65393000825 dimer interface [polypeptide binding]; other site 65393000826 beta-clamp/clamp loader binding surface; other site 65393000827 beta-clamp/translesion DNA polymerase binding surface; other site 65393000828 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393000829 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393000830 active site 65393000831 ATP binding site [chemical binding]; other site 65393000832 substrate binding site [chemical binding]; other site 65393000833 activation loop (A-loop); other site 65393000834 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 65393000835 Helix-turn-helix domains; Region: HTH; cl00088 65393000836 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 65393000837 putative dimerization interface [polypeptide binding]; other site 65393000838 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 65393000839 DNA photolyase; Region: DNA_photolyase; pfam00875 65393000840 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 65393000841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393000842 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 65393000843 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 65393000844 dimer interface [polypeptide binding]; other site 65393000845 putative anticodon binding site; other site 65393000846 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 65393000847 motif 1; other site 65393000848 active site 65393000849 motif 2; other site 65393000850 motif 3; other site 65393000851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 65393000852 Predicted transcriptional regulator [Transcription]; Region: COG1395 65393000853 non-specific DNA binding site [nucleotide binding]; other site 65393000854 salt bridge; other site 65393000855 sequence-specific DNA binding site [nucleotide binding]; other site 65393000856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393000857 dimerization interface [polypeptide binding]; other site 65393000858 Response regulator receiver domain; Region: Response_reg; pfam00072 65393000859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393000860 active site 65393000861 phosphorylation site [posttranslational modification] 65393000862 intermolecular recognition site; other site 65393000863 dimerization interface [polypeptide binding]; other site 65393000864 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 65393000865 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 65393000866 FAD binding site [chemical binding]; other site 65393000867 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 65393000868 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 65393000869 active site 65393000870 HIGH motif; other site 65393000871 dimer interface [polypeptide binding]; other site 65393000872 KMSKS motif; other site 65393000873 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 65393000874 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 65393000875 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393000876 Protein of unknown function (DUF565); Region: DUF565; pfam04483 65393000877 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 65393000878 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 65393000879 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 65393000880 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 65393000881 active site 65393000882 dimerization interface [polypeptide binding]; other site 65393000883 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 65393000884 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 65393000885 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 65393000886 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393000887 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 65393000888 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 65393000889 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 65393000890 active site 65393000891 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 65393000892 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393000893 phosphopeptide binding site; other site 65393000894 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 65393000895 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 65393000896 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 65393000897 ANP binding site [chemical binding]; other site 65393000898 Substrate Binding Site II [chemical binding]; other site 65393000899 Substrate Binding Site I [chemical binding]; other site 65393000900 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 65393000901 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393000902 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 65393000903 ligand binding site [chemical binding]; other site 65393000904 flexible hinge region; other site 65393000905 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 65393000906 putative switch regulator; other site 65393000907 non-specific DNA interactions [nucleotide binding]; other site 65393000908 DNA binding site [nucleotide binding] 65393000909 sequence specific DNA binding site [nucleotide binding]; other site 65393000910 putative cAMP binding site [chemical binding]; other site 65393000911 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 65393000912 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 65393000913 NAD binding site [chemical binding]; other site 65393000914 homotetramer interface [polypeptide binding]; other site 65393000915 homodimer interface [polypeptide binding]; other site 65393000916 substrate binding site [chemical binding]; other site 65393000917 active site 65393000918 UTRA domain; Region: UTRA; cl01230 65393000919 Membrane protein of unknown function; Region: DUF360; cl00850 65393000920 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 65393000921 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 65393000922 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 65393000923 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 65393000924 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 65393000925 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 65393000926 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393000927 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393000928 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 65393000929 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393000930 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 65393000931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393000932 S-adenosylmethionine binding site [chemical binding]; other site 65393000933 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393000934 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393000935 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 65393000936 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 65393000937 B12 binding site [chemical binding]; other site 65393000938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393000939 FeS/SAM binding site; other site 65393000940 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 65393000941 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 65393000942 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 65393000943 anti sigma factor interaction site; other site 65393000944 regulatory phosphorylation site [posttranslational modification]; other site 65393000945 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 65393000946 nucleotide binding site/active site [active] 65393000947 HIT family signature motif; other site 65393000948 catalytic residue [active] 65393000949 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 65393000950 catalytic motif [active] 65393000951 Catalytic residue [active] 65393000952 L-aspartate oxidase; Provisional; Region: PRK07395 65393000953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393000954 domain; Region: Succ_DH_flav_C; pfam02910 65393000955 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393000956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393000957 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393000958 Probable transposase; Region: OrfB_IS605; pfam01385 65393000959 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393000960 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 65393000961 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 65393000962 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 65393000963 dimer interface [polypeptide binding]; other site 65393000964 decamer (pentamer of dimers) interface [polypeptide binding]; other site 65393000965 catalytic triad [active] 65393000966 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 65393000967 generic binding surface II; other site 65393000968 generic binding surface I; other site 65393000969 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 65393000970 putative active site [active] 65393000971 putative catalytic site [active] 65393000972 putative Mg binding site IVb [ion binding]; other site 65393000973 putative phosphate binding site [ion binding]; other site 65393000974 putative DNA binding site [nucleotide binding]; other site 65393000975 putative Mg binding site IVa [ion binding]; other site 65393000976 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393000977 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 65393000978 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 65393000979 Apolipophorin-III precursor (apoLp-III); Region: ApoLp-III; pfam07464 65393000980 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 65393000981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393000982 binding surface 65393000983 TPR motif; other site 65393000984 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 65393000985 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 65393000986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 65393000987 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 65393000988 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 65393000989 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 65393000990 putative active site [active] 65393000991 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393000992 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 65393000993 Walker A/P-loop; other site 65393000994 ATP binding site [chemical binding]; other site 65393000995 Q-loop/lid; other site 65393000996 ABC transporter signature motif; other site 65393000997 Walker B; other site 65393000998 D-loop; other site 65393000999 H-loop/switch region; other site 65393001000 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 65393001001 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 65393001002 PPIC-type PPIASE domain; Region: Rotamase; cl08278 65393001003 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 65393001004 oligomeric interface; other site 65393001005 putative active site [active] 65393001006 homodimer interface [polypeptide binding]; other site 65393001007 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393001008 TPR motif; other site 65393001009 binding surface 65393001010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393001011 binding surface 65393001012 TPR motif; other site 65393001013 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 65393001014 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 65393001015 active site 65393001016 ATP binding site [chemical binding]; other site 65393001017 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 65393001018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393001019 FeS/SAM binding site; other site 65393001020 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 65393001021 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 65393001022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393001023 binding surface 65393001024 TPR motif; other site 65393001025 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 65393001026 putative active site pocket [active] 65393001027 4-fold oligomerization interface [polypeptide binding]; other site 65393001028 metal binding residues [ion binding]; metal-binding site 65393001029 3-fold/trimer interface [polypeptide binding]; other site 65393001030 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 65393001031 active site 65393001032 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 65393001033 CheB methylesterase; Region: CheB_methylest; pfam01339 65393001034 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 65393001035 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 65393001036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393001037 sensory histidine kinase AtoS; Provisional; Region: PRK11360 65393001038 PAS fold; Region: PAS; pfam00989 65393001039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393001040 putative active site [active] 65393001041 heme pocket [chemical binding]; other site 65393001042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393001043 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 65393001044 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393001045 putative active site [active] 65393001046 heme pocket [chemical binding]; other site 65393001047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393001048 dimer interface [polypeptide binding]; other site 65393001049 phosphorylation site [posttranslational modification] 65393001050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393001051 ATP binding site [chemical binding]; other site 65393001052 Mg2+ binding site [ion binding]; other site 65393001053 G-X-G motif; other site 65393001054 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 65393001055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393001056 active site 65393001057 phosphorylation site [posttranslational modification] 65393001058 intermolecular recognition site; other site 65393001059 dimerization interface [polypeptide binding]; other site 65393001060 aspartate aminotransferase; Provisional; Region: PRK05957 65393001061 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 65393001062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393001063 homodimer interface [polypeptide binding]; other site 65393001064 catalytic residue [active] 65393001065 PAS fold; Region: PAS; pfam00989 65393001066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393001067 putative active site [active] 65393001068 heme pocket [chemical binding]; other site 65393001069 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 65393001070 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 65393001071 putative switch regulator; other site 65393001072 non-specific DNA interactions [nucleotide binding]; other site 65393001073 DNA binding site [nucleotide binding] 65393001074 sequence specific DNA binding site [nucleotide binding]; other site 65393001075 putative cAMP binding site [chemical binding]; other site 65393001076 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 65393001077 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393001078 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393001079 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 65393001080 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 65393001081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393001082 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 65393001083 NAD(P) binding site [chemical binding]; other site 65393001084 active site 65393001085 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 65393001086 E3 interaction surface; other site 65393001087 lipoyl attachment site [posttranslational modification]; other site 65393001088 e3 binding domain; Region: E3_binding; pfam02817 65393001089 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 65393001090 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 65393001091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393001092 Probable transposase; Region: OrfB_IS605; pfam01385 65393001093 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393001094 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393001095 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393001096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 65393001097 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 65393001098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 65393001099 Family of unknown function (DUF490); Region: DUF490; pfam04357 65393001100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393001101 BT1 family; Region: BT1; pfam03092 65393001102 putative substrate translocation pore; other site 65393001103 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 65393001104 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 65393001105 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 65393001106 putative ADP-ribose binding site [chemical binding]; other site 65393001107 putative active site [active] 65393001108 Glutaminase; Region: Glutaminase; cl00907 65393001109 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 65393001110 putative active site [active] 65393001111 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 65393001112 HerA helicase [Replication, recombination, and repair]; Region: COG0433 65393001113 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393001114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393001115 binding surface 65393001116 TPR motif; other site 65393001117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393001118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393001119 binding surface 65393001120 TPR motif; other site 65393001121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393001122 binding surface 65393001123 TPR motif; other site 65393001124 Nitrogen regulatory protein P-II; Region: P-II; cl00412 65393001125 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 65393001126 active site 65393001127 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 65393001128 putative acyl-acceptor binding pocket; other site 65393001129 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 65393001130 catalytic residues [active] 65393001131 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 65393001132 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 65393001133 metal binding site 2 [ion binding]; metal-binding site 65393001134 putative DNA binding helix; other site 65393001135 metal binding site 1 [ion binding]; metal-binding site 65393001136 dimer interface [polypeptide binding]; other site 65393001137 structural Zn2+ binding site [ion binding]; other site 65393001138 Response regulator receiver domain; Region: Response_reg; pfam00072 65393001139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393001140 active site 65393001141 phosphorylation site [posttranslational modification] 65393001142 intermolecular recognition site; other site 65393001143 dimerization interface [polypeptide binding]; other site 65393001144 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 65393001145 cell division protein; Validated; Region: ftsH; CHL00176 65393001146 FtsH Extracellular; Region: FtsH_ext; pfam06480 65393001147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393001148 Walker A motif; other site 65393001149 ATP binding site [chemical binding]; other site 65393001150 Walker B motif; other site 65393001151 arginine finger; other site 65393001152 Peptidase family M41; Region: Peptidase_M41; pfam01434 65393001153 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393001154 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393001155 active site 65393001156 ATP binding site [chemical binding]; other site 65393001157 substrate binding site [chemical binding]; other site 65393001158 activation loop (A-loop); other site 65393001159 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 65393001160 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 65393001161 Mg++ binding site [ion binding]; other site 65393001162 putative catalytic motif [active] 65393001163 putative substrate binding site [chemical binding]; other site 65393001164 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 65393001165 Vitamin K epoxide reductase family; Region: VKOR; cl01729 65393001166 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 65393001167 BtpA family; Region: BtpA; cl00440 65393001168 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 65393001169 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 65393001170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393001171 FeS/SAM binding site; other site 65393001172 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 65393001173 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 65393001174 ligand binding site; other site 65393001175 oligomer interface; other site 65393001176 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 65393001177 dimer interface [polypeptide binding]; other site 65393001178 N-terminal domain interface [polypeptide binding]; other site 65393001179 sulfate 1 binding site; other site 65393001180 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 65393001181 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 65393001182 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 65393001183 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 65393001184 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 65393001185 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 65393001186 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 65393001187 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 65393001188 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 65393001189 active site 65393001190 substrate binding site [chemical binding]; other site 65393001191 cosubstrate binding site; other site 65393001192 catalytic site [active] 65393001193 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 65393001194 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393001195 Flavin Reductases; Region: FlaRed; cl00801 65393001196 Phosphate-starvation-inducible E; Region: PsiE; cl01264 65393001197 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 65393001198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393001199 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 65393001200 Flavin Reductases; Region: FlaRed; cl00801 65393001201 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 65393001202 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 65393001203 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393001204 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 65393001205 Bacterial SH3 domain; Region: SH3_3; cl02551 65393001206 TspO/MBR family; Region: TspO_MBR; cl01379 65393001207 short chain dehydrogenase; Provisional; Region: PRK06181 65393001208 classical (c) SDRs; Region: SDR_c; cd05233 65393001209 NAD(P) binding site [chemical binding]; other site 65393001210 active site 65393001211 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 65393001212 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 65393001213 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393001214 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 65393001215 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 65393001216 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 65393001217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 65393001218 dimer interface [polypeptide binding]; other site 65393001219 phosphorylation site [posttranslational modification] 65393001220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393001221 ATP binding site [chemical binding]; other site 65393001222 Mg2+ binding site [ion binding]; other site 65393001223 G-X-G motif; other site 65393001224 putative acyltransferase; Provisional; Region: PRK05790 65393001225 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 65393001226 dimer interface [polypeptide binding]; other site 65393001227 active site 65393001228 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 65393001229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393001230 NAD(P) binding site [chemical binding]; other site 65393001231 active site 65393001232 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 65393001233 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 65393001234 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 65393001235 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 65393001236 catalytic motif [active] 65393001237 Zn binding site [ion binding]; other site 65393001238 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 65393001239 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 65393001240 Response regulator receiver domain; Region: Response_reg; pfam00072 65393001241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393001242 active site 65393001243 phosphorylation site [posttranslational modification] 65393001244 intermolecular recognition site; other site 65393001245 dimerization interface [polypeptide binding]; other site 65393001246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 65393001247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393001248 ATP binding site [chemical binding]; other site 65393001249 Mg2+ binding site [ion binding]; other site 65393001250 G-X-G motif; other site 65393001251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393001252 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 65393001253 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 65393001254 Stage II sporulation protein; Region: SpoIID; pfam08486 65393001255 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 65393001256 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 65393001257 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 65393001258 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 65393001259 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393001260 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 65393001261 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 65393001262 dimer interface [polypeptide binding]; other site 65393001263 motif 1; other site 65393001264 active site 65393001265 motif 2; other site 65393001266 motif 3; other site 65393001267 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 65393001268 HSP70 interaction site [polypeptide binding]; other site 65393001269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393001270 binding surface 65393001271 TPR motif; other site 65393001272 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 65393001273 active site 65393001274 dimerization interface [polypeptide binding]; other site 65393001275 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 65393001276 catalytic loop [active] 65393001277 iron binding site [ion binding]; other site 65393001278 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 65393001279 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 65393001280 ChaB; Region: ChaB; cl01887 65393001281 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 65393001282 classical (c) SDRs; Region: SDR_c; cd05233 65393001283 NAD(P) binding site [chemical binding]; other site 65393001284 active site 65393001285 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 65393001286 trimer interface [polypeptide binding]; other site 65393001287 active site 65393001288 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 65393001289 catalytic site [active] 65393001290 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 65393001291 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 65393001292 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 65393001293 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 65393001294 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 65393001295 active site 65393001296 Substrate binding site; other site 65393001297 Mg++ binding site; other site 65393001298 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 65393001299 putative trimer interface [polypeptide binding]; other site 65393001300 putative CoA binding site [chemical binding]; other site 65393001301 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 65393001302 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 65393001303 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 65393001304 dimer interface [polypeptide binding]; other site 65393001305 ssDNA binding site [nucleotide binding]; other site 65393001306 tetramer (dimer of dimers) interface [polypeptide binding]; other site 65393001307 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 65393001308 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 65393001309 putative active site [active] 65393001310 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 65393001311 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 65393001312 Catalytic site [active] 65393001313 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 65393001314 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 65393001315 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 65393001316 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 65393001317 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393001318 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 65393001319 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 65393001320 HSP70 interaction site [polypeptide binding]; other site 65393001321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393001322 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393001323 Probable transposase; Region: OrfB_IS605; pfam01385 65393001324 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393001325 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 65393001326 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 65393001327 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 65393001328 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393001329 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393001330 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 65393001331 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 65393001332 Walker A/P-loop; other site 65393001333 ATP binding site [chemical binding]; other site 65393001334 Q-loop/lid; other site 65393001335 ABC transporter signature motif; other site 65393001336 Walker B; other site 65393001337 D-loop; other site 65393001338 H-loop/switch region; other site 65393001339 CpeS-like protein; Region: CpeS; pfam09367 65393001340 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 65393001341 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 65393001342 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 65393001343 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 65393001344 active site 65393001345 nucleophile elbow; other site 65393001346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393001347 Probable transposase; Region: OrfB_IS605; pfam01385 65393001348 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393001349 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 65393001350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393001351 Protein of unknown function (DUF552); Region: DUF552; cl00775 65393001352 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 65393001353 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 65393001354 catalytic residue [active] 65393001355 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 65393001356 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 65393001357 active site 65393001358 catalytic triad [active] 65393001359 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 65393001360 putative active site [active] 65393001361 putative metal binding residues [ion binding]; other site 65393001362 signature motif; other site 65393001363 putative dimer interface [polypeptide binding]; other site 65393001364 putative phosphate binding site [ion binding]; other site 65393001365 secreted effector protein PipB; Provisional; Region: PRK15197 65393001366 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393001367 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393001368 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393001369 Predicted domain in sensory proteins (DUF2308); Region: DUF2308; cl01731 65393001370 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 65393001371 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393001372 NurA domain; Region: NurA; cl09134 65393001373 GTPase RsgA; Reviewed; Region: PRK12289 65393001374 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 65393001375 GTPase/OB domain interface [polypeptide binding]; other site 65393001376 GTPase/Zn-binding domain interface [polypeptide binding]; other site 65393001377 GTP/Mg2+ binding site [chemical binding]; other site 65393001378 G4 box; other site 65393001379 G5 box; other site 65393001380 G1 box; other site 65393001381 Switch I region; other site 65393001382 G2 box; other site 65393001383 G3 box; other site 65393001384 Switch II region; other site 65393001385 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 65393001386 CPxP motif; other site 65393001387 chaperone protein DnaJ; Provisional; Region: PRK14293 65393001388 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 65393001389 HSP70 interaction site [polypeptide binding]; other site 65393001390 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 65393001391 substrate binding site [polypeptide binding]; other site 65393001392 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 65393001393 Zn binding sites [ion binding]; other site 65393001394 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 65393001395 dimer interface [polypeptide binding]; other site 65393001396 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393001397 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393001398 large tegument protein UL36; Provisional; Region: PHA03247 65393001399 Peptidase family M23; Region: Peptidase_M23; pfam01551 65393001400 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 65393001401 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 65393001402 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 65393001403 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 65393001404 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 65393001405 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 65393001406 G1 box; other site 65393001407 GTP/Mg2+ binding site [chemical binding]; other site 65393001408 Switch I region; other site 65393001409 G2 box; other site 65393001410 Switch II region; other site 65393001411 G3 box; other site 65393001412 G4 box; other site 65393001413 G5 box; other site 65393001414 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 65393001415 CpeS-like protein; Region: CpeS; pfam09367 65393001416 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393001417 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 65393001418 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393001419 putative active site [active] 65393001420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393001421 Photosystem II protein; Region: PSII; cl08223 65393001422 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 65393001423 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 65393001424 D1 interface; other site 65393001425 chlorophyll binding site; other site 65393001426 pheophytin binding site; other site 65393001427 beta carotene binding site; other site 65393001428 cytochrome b559 beta interface; other site 65393001429 quinone binding site; other site 65393001430 cytochrome b559 alpha interface; other site 65393001431 protein J interface; other site 65393001432 protein H interface; other site 65393001433 protein X interface; other site 65393001434 core light harvesting protein interface; other site 65393001435 protein L interface; other site 65393001436 CP43 interface; other site 65393001437 protein T interface; other site 65393001438 Fe binding site [ion binding]; other site 65393001439 protein M interface; other site 65393001440 Mn-stabilizing polypeptide interface; other site 65393001441 bromide binding site; other site 65393001442 cytochrome c-550 interface; other site 65393001443 Ycf4; Region: Ycf4; cl03567 65393001444 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 65393001445 active site 65393001446 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 65393001447 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 65393001448 dimer interface [polypeptide binding]; other site 65393001449 active site 65393001450 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 65393001451 HSP70 interaction site [polypeptide binding]; other site 65393001452 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 65393001453 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 65393001454 tetramer interface [polypeptide binding]; other site 65393001455 TPP-binding site [chemical binding]; other site 65393001456 heterodimer interface [polypeptide binding]; other site 65393001457 phosphorylation loop region [posttranslational modification] 65393001458 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 65393001459 Ion channel; Region: Ion_trans_2; cl11596 65393001460 Penicillin amidase; Region: Penicil_amidase; pfam01804 65393001461 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 65393001462 active site 65393001463 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 65393001464 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393001465 putative active site [active] 65393001466 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393001467 recombination protein RecR; Reviewed; Region: recR; PRK00076 65393001468 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 65393001469 RecR protein; Region: RecR; pfam02132 65393001470 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 65393001471 putative active site [active] 65393001472 putative metal-binding site [ion binding]; other site 65393001473 tetramer interface [polypeptide binding]; other site 65393001474 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 65393001475 MoaE interaction surface [polypeptide binding]; other site 65393001476 MoeB interaction surface [polypeptide binding]; other site 65393001477 thiocarboxylated glycine; other site 65393001478 threonine synthase; Validated; Region: PRK07591 65393001479 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 65393001480 homodimer interface [polypeptide binding]; other site 65393001481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393001482 catalytic residue [active] 65393001483 PAS domain S-box; Region: sensory_box; TIGR00229 65393001484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393001485 putative active site [active] 65393001486 heme pocket [chemical binding]; other site 65393001487 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 65393001488 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 65393001489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393001490 putative active site [active] 65393001491 heme pocket [chemical binding]; other site 65393001492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393001493 putative active site [active] 65393001494 heme pocket [chemical binding]; other site 65393001495 PAS fold; Region: PAS_3; pfam08447 65393001496 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 65393001497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393001498 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 65393001499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393001500 putative active site [active] 65393001501 heme pocket [chemical binding]; other site 65393001502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393001503 putative active site [active] 65393001504 heme pocket [chemical binding]; other site 65393001505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393001506 metal binding site [ion binding]; metal-binding site 65393001507 active site 65393001508 I-site; other site 65393001509 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393001510 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 65393001511 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 65393001512 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 65393001513 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 65393001514 Walker A motif; other site 65393001515 ATP binding site [chemical binding]; other site 65393001516 Walker B motif; other site 65393001517 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393001518 ATP binding site [chemical binding]; other site 65393001519 Walker B motif; other site 65393001520 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 65393001521 tetramer interface [polypeptide binding]; other site 65393001522 dimer interface [polypeptide binding]; other site 65393001523 KaiA domain; Region: KaiA; pfam07688 65393001524 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 65393001525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393001526 dimer interface [polypeptide binding]; other site 65393001527 phosphorylation site [posttranslational modification] 65393001528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393001529 ATP binding site [chemical binding]; other site 65393001530 Mg2+ binding site [ion binding]; other site 65393001531 G-X-G motif; other site 65393001532 Response regulator receiver domain; Region: Response_reg; pfam00072 65393001533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393001534 active site 65393001535 phosphorylation site [posttranslational modification] 65393001536 intermolecular recognition site; other site 65393001537 dimerization interface [polypeptide binding]; other site 65393001538 RDD family; Region: RDD; cl00746 65393001539 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 65393001540 C-terminal peptidase (prc); Region: prc; TIGR00225 65393001541 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 65393001542 protein binding site [polypeptide binding]; other site 65393001543 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 65393001544 Catalytic dyad [active] 65393001545 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 65393001546 nudix motif; other site 65393001547 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 65393001548 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 65393001549 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 65393001550 homodimer interface [polypeptide binding]; other site 65393001551 NADP binding site [chemical binding]; other site 65393001552 substrate binding site [chemical binding]; other site 65393001553 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 65393001554 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 65393001555 substrate binding pocket [chemical binding]; other site 65393001556 chain length determination region; other site 65393001557 substrate-Mg2+ binding site; other site 65393001558 catalytic residues [active] 65393001559 aspartate-rich region 1; other site 65393001560 active site lid residues [active] 65393001561 aspartate-rich region 2; other site 65393001562 Divergent PAP2 family; Region: DUF212; cl00855 65393001563 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 65393001564 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 65393001565 cyanophycin synthetase; Provisional; Region: PRK14016 65393001566 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393001567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393001568 Walker B; other site 65393001569 H-loop/switch region; other site 65393001570 Protein of unknown function (DUF785); Region: DUF785; cl01682 65393001571 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 65393001572 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 65393001573 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 65393001574 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393001575 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 65393001576 protein binding site [polypeptide binding]; other site 65393001577 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 65393001578 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 65393001579 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 65393001580 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393001581 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393001582 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 65393001583 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 65393001584 active site 65393001585 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 65393001586 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 65393001587 active site 65393001588 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 65393001589 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 65393001590 Frequency clock protein; Region: FRQ; pfam09421 65393001591 Double zinc ribbon; Region: DZR; pfam12773 65393001592 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 65393001593 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 65393001594 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 65393001595 HSP70 interaction site [polypeptide binding]; other site 65393001596 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393001597 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393001598 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393001599 Vitamin K epoxide reductase family; Region: VKOR; cl01729 65393001600 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 65393001601 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 65393001602 metal binding site [ion binding]; metal-binding site 65393001603 dimer interface [polypeptide binding]; other site 65393001604 BON domain; Region: BON; cl02771 65393001605 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 65393001606 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 65393001607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393001608 dimer interface [polypeptide binding]; other site 65393001609 conserved gate region; other site 65393001610 putative PBP binding loops; other site 65393001611 ABC-ATPase subunit interface; other site 65393001612 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 65393001613 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 65393001614 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 65393001615 Walker A/P-loop; other site 65393001616 ATP binding site [chemical binding]; other site 65393001617 Q-loop/lid; other site 65393001618 ABC transporter signature motif; other site 65393001619 Walker B; other site 65393001620 D-loop; other site 65393001621 H-loop/switch region; other site 65393001622 methionine aminopeptidase; Provisional; Region: PRK08671 65393001623 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 65393001624 active site 65393001625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393001626 Coenzyme A binding pocket [chemical binding]; other site 65393001627 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393001628 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 65393001629 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 65393001630 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 65393001631 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 65393001632 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 65393001633 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393001634 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 65393001635 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 65393001636 putative dimer interface [polypeptide binding]; other site 65393001637 N-terminal domain interface [polypeptide binding]; other site 65393001638 putative substrate binding pocket (H-site) [chemical binding]; other site 65393001639 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 65393001640 RNA/DNA binding site [nucleotide binding]; other site 65393001641 RRM dimerization site [polypeptide binding]; other site 65393001642 PUCC protein; Region: PUCC; pfam03209 65393001643 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 65393001644 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 65393001645 active site 65393001646 metal binding site [ion binding]; metal-binding site 65393001647 DNA binding site [nucleotide binding] 65393001648 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393001649 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393001650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 65393001651 Helix-turn-helix domains; Region: HTH; cl00088 65393001652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 65393001653 dimerization interface [polypeptide binding]; other site 65393001654 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 65393001655 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 65393001656 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 65393001657 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 65393001658 C-terminal domain interface [polypeptide binding]; other site 65393001659 active site 65393001660 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 65393001661 active site 65393001662 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 65393001663 Uncharacterized conserved protein [Function unknown]; Region: COG1262 65393001664 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 65393001665 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 65393001666 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 65393001667 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 65393001668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393001669 active site 65393001670 phosphorylation site [posttranslational modification] 65393001671 intermolecular recognition site; other site 65393001672 dimerization interface [polypeptide binding]; other site 65393001673 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393001674 GAF domain; Region: GAF; cl00853 65393001675 PAS fold; Region: PAS; pfam00989 65393001676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393001677 putative active site [active] 65393001678 heme pocket [chemical binding]; other site 65393001679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393001680 putative active site [active] 65393001681 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 65393001682 heme pocket [chemical binding]; other site 65393001683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393001684 dimer interface [polypeptide binding]; other site 65393001685 phosphorylation site [posttranslational modification] 65393001686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393001687 ATP binding site [chemical binding]; other site 65393001688 Mg2+ binding site [ion binding]; other site 65393001689 G-X-G motif; other site 65393001690 Response regulator receiver domain; Region: Response_reg; pfam00072 65393001691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393001692 active site 65393001693 phosphorylation site [posttranslational modification] 65393001694 intermolecular recognition site; other site 65393001695 dimerization interface [polypeptide binding]; other site 65393001696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393001697 Coenzyme A binding pocket [chemical binding]; other site 65393001698 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 65393001699 putative hydrophobic ligand binding site [chemical binding]; other site 65393001700 Uncharacterized conserved protein [Function unknown]; Region: COG3349 65393001701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393001702 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 65393001703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393001704 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 65393001705 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 65393001706 active site residue [active] 65393001707 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 65393001708 S-layer homology domain; Region: SLH; pfam00395 65393001709 S-layer homology domain; Region: SLH; pfam00395 65393001710 GatB domain; Region: GatB_Yqey; cl11497 65393001711 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 65393001712 acetolactate synthase; Reviewed; Region: PRK08322 65393001713 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 65393001714 PYR/PP interface [polypeptide binding]; other site 65393001715 dimer interface [polypeptide binding]; other site 65393001716 TPP binding site [chemical binding]; other site 65393001717 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 65393001718 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 65393001719 TPP-binding site [chemical binding]; other site 65393001720 dimer interface [polypeptide binding]; other site 65393001721 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393001722 GAF domain; Region: GAF; cl00853 65393001723 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393001724 metal binding site [ion binding]; metal-binding site 65393001725 active site 65393001726 I-site; other site 65393001727 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 65393001728 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 65393001729 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 65393001730 shikimate binding site; other site 65393001731 NAD(P) binding site [chemical binding]; other site 65393001732 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393001733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393001734 active site 65393001735 phosphorylation site [posttranslational modification] 65393001736 intermolecular recognition site; other site 65393001737 dimerization interface [polypeptide binding]; other site 65393001738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393001739 DNA binding site [nucleotide binding] 65393001740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 65393001741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393001742 dimer interface [polypeptide binding]; other site 65393001743 phosphorylation site [posttranslational modification] 65393001744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393001745 ATP binding site [chemical binding]; other site 65393001746 Mg2+ binding site [ion binding]; other site 65393001747 G-X-G motif; other site 65393001748 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 65393001749 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 65393001750 putative active site [active] 65393001751 catalytic site [active] 65393001752 putative metal binding site [ion binding]; other site 65393001753 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 65393001754 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 65393001755 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 65393001756 oligomeric interface; other site 65393001757 putative active site [active] 65393001758 homodimer interface [polypeptide binding]; other site 65393001759 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 65393001760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393001761 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 65393001762 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 65393001763 Domain of unknown function DUF21; Region: DUF21; pfam01595 65393001764 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 65393001765 Transporter associated domain; Region: CorC_HlyC; cl08393 65393001766 Nucleoside recognition; Region: Gate; cl00486 65393001767 Nucleoside recognition; Region: Gate; cl00486 65393001768 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 65393001769 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 65393001770 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 65393001771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393001772 TPR motif; other site 65393001773 binding surface 65393001774 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 65393001775 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 65393001776 Domain of unknown function (DUF814); Region: DUF814; pfam05670 65393001777 Rhomboid family; Region: Rhomboid; cl11446 65393001778 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 65393001779 catalytic motif [active] 65393001780 Zn binding site [ion binding]; other site 65393001781 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393001782 putative active site [active] 65393001783 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 65393001784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 65393001785 substrate binding pocket [chemical binding]; other site 65393001786 membrane-bound complex binding site; other site 65393001787 hinge residues; other site 65393001788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 65393001789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393001790 putative PBP binding loops; other site 65393001791 dimer interface [polypeptide binding]; other site 65393001792 ABC-ATPase subunit interface; other site 65393001793 TIR domain; Region: TIR; cl02060 65393001794 TIR domain; Region: TIR; cl02060 65393001795 TIR domain; Region: TIR; cl02060 65393001796 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393001797 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 65393001798 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393001799 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393001800 structural tetrad; other site 65393001801 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393001802 structural tetrad; other site 65393001803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393001804 dimer interface [polypeptide binding]; other site 65393001805 conserved gate region; other site 65393001806 putative PBP binding loops; other site 65393001807 ABC-ATPase subunit interface; other site 65393001808 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 65393001809 IHF dimer interface [polypeptide binding]; other site 65393001810 IHF - DNA interface [nucleotide binding]; other site 65393001811 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 65393001812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 65393001813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393001814 homodimer interface [polypeptide binding]; other site 65393001815 catalytic residue [active] 65393001816 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 65393001817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393001818 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 65393001819 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393001820 putative active site [active] 65393001821 thymidylate kinase; Region: DTMP_kinase; TIGR00041 65393001822 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 65393001823 TMP-binding site; other site 65393001824 ATP-binding site [chemical binding]; other site 65393001825 tetrahydromethanopterin S-methyltransferase subunit A; Provisional; Region: PRK00964 65393001826 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 65393001827 dimerization interface [polypeptide binding]; other site 65393001828 active site 65393001829 dihydropteroate synthase-related protein; Region: TIGR00284 65393001830 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 65393001831 trimer interface [polypeptide binding]; other site 65393001832 active site 65393001833 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 65393001834 trimer interface [polypeptide binding]; other site 65393001835 active site 65393001836 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 65393001837 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393001838 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393001839 Walker A/P-loop; other site 65393001840 ATP binding site [chemical binding]; other site 65393001841 Q-loop/lid; other site 65393001842 ABC transporter signature motif; other site 65393001843 Walker B; other site 65393001844 D-loop; other site 65393001845 H-loop/switch region; other site 65393001846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393001847 putative substrate translocation pore; other site 65393001848 Major Facilitator Superfamily; Region: MFS_1; pfam07690 65393001849 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 65393001850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393001851 Calx-beta domain; Region: Calx-beta; cl02522 65393001852 Calx-beta domain; Region: Calx-beta; cl02522 65393001853 Calx-beta domain; Region: Calx-beta; cl02522 65393001854 Calx-beta domain; Region: Calx-beta; cl02522 65393001855 Calx-beta domain; Region: Calx-beta; cl02522 65393001856 Calx-beta domain; Region: Calx-beta; cl02522 65393001857 Calx-beta domain; Region: Calx-beta; cl02522 65393001858 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 65393001859 histidinol dehydrogenase; Region: hisD; TIGR00069 65393001860 NAD binding site [chemical binding]; other site 65393001861 dimerization interface [polypeptide binding]; other site 65393001862 product binding site; other site 65393001863 substrate binding site [chemical binding]; other site 65393001864 zinc binding site [ion binding]; other site 65393001865 catalytic residues [active] 65393001866 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 65393001867 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 65393001868 active site 65393001869 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 65393001870 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 65393001871 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 65393001872 RPB1 interaction site [polypeptide binding]; other site 65393001873 RPB10 interaction site [polypeptide binding]; other site 65393001874 RPB11 interaction site [polypeptide binding]; other site 65393001875 RPB3 interaction site [polypeptide binding]; other site 65393001876 RPB12 interaction site [polypeptide binding]; other site 65393001877 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 65393001878 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 65393001879 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 65393001880 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 65393001881 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 65393001882 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 65393001883 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 65393001884 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 65393001885 DNA binding site [nucleotide binding] 65393001886 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 65393001887 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 65393001888 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 65393001889 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 65393001890 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393001891 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 65393001892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393001893 S-adenosylmethionine binding site [chemical binding]; other site 65393001894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 65393001895 Lysozyme family protein [General function prediction only]; Region: COG5526 65393001896 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 65393001897 NlpC/P60 family; Region: NLPC_P60; cl11438 65393001898 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393001899 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393001900 Probable transposase; Region: OrfB_IS605; pfam01385 65393001901 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393001902 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 65393001903 active site flap/lid [active] 65393001904 nucleophilic elbow; other site 65393001905 catalytic triad [active] 65393001906 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 65393001907 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 65393001908 DNA binding residues [nucleotide binding] 65393001909 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 65393001910 catalytic residues [active] 65393001911 catalytic nucleophile [active] 65393001912 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 65393001913 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393001914 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 65393001915 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 65393001916 dihydrodipicolinate synthase; Region: dapA; TIGR00674 65393001917 dimer interface [polypeptide binding]; other site 65393001918 active site 65393001919 catalytic residue [active] 65393001920 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 65393001921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393001922 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 65393001923 ATP-sulfurylase; Region: ATPS; cd00517 65393001924 active site 65393001925 HXXH motif; other site 65393001926 flexible loop; other site 65393001927 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 65393001928 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 65393001929 hydrophobic ligand binding site; other site 65393001930 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 65393001931 active site 65393001932 catalytic triad [active] 65393001933 oxyanion hole [active] 65393001934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 65393001935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393001936 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 65393001937 O-Antigen ligase; Region: Wzy_C; cl04850 65393001938 Predicted amidohydrolase [General function prediction only]; Region: COG0388 65393001939 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 65393001940 putative active site [active] 65393001941 catalytic triad [active] 65393001942 dimer interface [polypeptide binding]; other site 65393001943 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 65393001944 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 65393001945 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393001946 catalytic residue [active] 65393001947 Flagellin N-methylase; Region: FliB; cl00497 65393001948 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 65393001949 substrate binding pocket [chemical binding]; other site 65393001950 substrate-Mg2+ binding site; other site 65393001951 aspartate-rich region 1; other site 65393001952 aspartate-rich region 2; other site 65393001953 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 65393001954 active site 65393001955 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 65393001956 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 65393001957 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 65393001958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393001959 Coenzyme A binding pocket [chemical binding]; other site 65393001960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393001961 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393001962 Probable transposase; Region: OrfB_IS605; pfam01385 65393001963 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393001964 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393001965 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 65393001966 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 65393001967 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 65393001968 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 65393001969 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 65393001970 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393001971 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 65393001972 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 65393001973 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393001974 S-layer homology domain; Region: SLH; pfam00395 65393001975 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 65393001976 FeoA domain; Region: FeoA; cl00838 65393001977 Permease family; Region: Xan_ur_permease; cl00967 65393001978 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 65393001979 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 65393001980 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 65393001981 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 65393001982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393001983 dimer interface [polypeptide binding]; other site 65393001984 phosphorylation site [posttranslational modification] 65393001985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393001986 ATP binding site [chemical binding]; other site 65393001987 Mg2+ binding site [ion binding]; other site 65393001988 G-X-G motif; other site 65393001989 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 65393001990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393001991 active site 65393001992 phosphorylation site [posttranslational modification] 65393001993 intermolecular recognition site; other site 65393001994 dimerization interface [polypeptide binding]; other site 65393001995 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393001996 DNA binding residues [nucleotide binding] 65393001997 dimerization interface [polypeptide binding]; other site 65393001998 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393001999 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393002000 active site 65393002001 ATP binding site [chemical binding]; other site 65393002002 substrate binding site [chemical binding]; other site 65393002003 activation loop (A-loop); other site 65393002004 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002005 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002006 Inner membrane protein import complex subunit Tim54; Region: Tim54; pfam11711 65393002007 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 65393002008 catalytic residues [active] 65393002009 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 65393002010 PsbJ; Region: PsbJ; cl09469 65393002011 PsbL protein; Region: PsbL; cl03581 65393002012 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 65393002013 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 65393002014 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 65393002015 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 65393002016 Ycf48-like protein; Provisional; Region: PRK13684 65393002017 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 65393002018 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 65393002019 Rubredoxin; Region: Rubredoxin; pfam00301 65393002020 iron binding site [ion binding]; other site 65393002021 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 65393002022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393002023 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393002024 putative active site [active] 65393002025 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393002026 putative active site [active] 65393002027 ParA-like protein; Provisional; Region: PHA02518 65393002028 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393002029 P-loop; other site 65393002030 Magnesium ion binding site [ion binding]; other site 65393002031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393002032 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393002033 Probable transposase; Region: OrfB_IS605; pfam01385 65393002034 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393002035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002036 binding surface 65393002037 TPR motif; other site 65393002038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002039 binding surface 65393002040 TPR motif; other site 65393002041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002042 binding surface 65393002043 TPR motif; other site 65393002044 peptide synthase; Provisional; Region: PRK12467 65393002045 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393002046 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393002047 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 65393002048 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393002049 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 65393002050 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 65393002051 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 65393002052 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 65393002053 Protein of unknown function (DUF790); Region: DUF790; pfam05626 65393002054 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 65393002055 Cytochrome P450; Region: p450; cl12078 65393002056 short chain dehydrogenase; Provisional; Region: PRK12828 65393002057 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 65393002058 NADP binding site [chemical binding]; other site 65393002059 homodimer interface [polypeptide binding]; other site 65393002060 active site 65393002061 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393002062 phosphopeptide binding site; other site 65393002063 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 65393002064 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 65393002065 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 65393002066 C-terminal domain interface [polypeptide binding]; other site 65393002067 GSH binding site (G-site) [chemical binding]; other site 65393002068 dimer interface [polypeptide binding]; other site 65393002069 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 65393002070 N-terminal domain interface [polypeptide binding]; other site 65393002071 dimer interface [polypeptide binding]; other site 65393002072 substrate binding pocket (H-site) [chemical binding]; other site 65393002073 Uncharacterised ACR, YagE family COG1723; Region: DUF155; cl00751 65393002074 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 65393002075 haemagglutination activity domain; Region: Haemagg_act; cl05436 65393002076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393002077 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 65393002078 NAD(P) binding pocket [chemical binding]; other site 65393002079 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 65393002080 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 65393002081 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 65393002082 yiaA/B two helix domain; Region: YiaAB; cl01759 65393002083 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393002084 diaminopimelate decarboxylase; Region: lysA; TIGR01048 65393002085 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 65393002086 active site 65393002087 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 65393002088 substrate binding site [chemical binding]; other site 65393002089 catalytic residues [active] 65393002090 dimer interface [polypeptide binding]; other site 65393002091 TIGR00159 family protein; Region: TIGR00159 65393002092 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 65393002093 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 65393002094 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 65393002095 catalytic residue [active] 65393002096 putative FPP diphosphate binding site; other site 65393002097 putative FPP binding hydrophobic cleft; other site 65393002098 dimer interface [polypeptide binding]; other site 65393002099 putative IPP diphosphate binding site; other site 65393002100 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393002101 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 65393002102 YcfA-like protein; Region: YcfA; cl00752 65393002103 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 65393002104 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 65393002105 substrate binding site [chemical binding]; other site 65393002106 ligand binding site [chemical binding]; other site 65393002107 EcsC protein family; Region: EcsC; pfam12787 65393002108 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 65393002109 active site 65393002110 catalytic triad [active] 65393002111 oxyanion hole [active] 65393002112 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 65393002113 Amino acid permease; Region: AA_permease; cl00524 65393002114 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 65393002115 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393002116 Q-loop/lid; other site 65393002117 ABC transporter signature motif; other site 65393002118 Walker B; other site 65393002119 D-loop; other site 65393002120 H-loop/switch region; other site 65393002121 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607 65393002122 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 65393002123 active site 65393002124 Probable transposase; Region: OrfB_IS605; pfam01385 65393002125 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393002126 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393002127 alanine racemase; Reviewed; Region: alr; PRK00053 65393002128 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 65393002129 active site 65393002130 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 65393002131 dimer interface [polypeptide binding]; other site 65393002132 substrate binding site [chemical binding]; other site 65393002133 catalytic residues [active] 65393002134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393002135 TPR motif; other site 65393002136 binding surface 65393002137 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 65393002138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002139 binding surface 65393002140 TPR motif; other site 65393002141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002142 binding surface 65393002143 TPR motif; other site 65393002144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002145 binding surface 65393002146 TPR motif; other site 65393002147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393002148 binding surface 65393002149 TPR motif; other site 65393002150 CHAT domain; Region: CHAT; cl02083 65393002151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002152 TPR motif; other site 65393002153 binding surface 65393002154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002155 binding surface 65393002156 TPR motif; other site 65393002157 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 65393002158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002159 binding surface 65393002160 TPR motif; other site 65393002161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002162 binding surface 65393002163 TPR motif; other site 65393002164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002165 binding surface 65393002166 TPR motif; other site 65393002167 CHAT domain; Region: CHAT; cl02083 65393002168 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 65393002169 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 65393002170 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 65393002171 putative ligand binding site [chemical binding]; other site 65393002172 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 65393002173 NlpC/P60 family; Region: NLPC_P60; cl11438 65393002174 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 65393002175 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 65393002176 Walker A/P-loop; other site 65393002177 ATP binding site [chemical binding]; other site 65393002178 Q-loop/lid; other site 65393002179 ABC transporter signature motif; other site 65393002180 Walker B; other site 65393002181 D-loop; other site 65393002182 H-loop/switch region; other site 65393002183 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 65393002184 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393002185 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 65393002186 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 65393002187 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 65393002188 proposed catalytic triad [active] 65393002189 active site nucleophile [active] 65393002190 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 65393002191 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 65393002192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002193 TPR motif; other site 65393002194 binding surface 65393002195 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 65393002196 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 65393002197 Walker A/P-loop; other site 65393002198 ATP binding site [chemical binding]; other site 65393002199 Q-loop/lid; other site 65393002200 ABC transporter signature motif; other site 65393002201 Walker B; other site 65393002202 D-loop; other site 65393002203 H-loop/switch region; other site 65393002204 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 65393002205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393002206 S-adenosylmethionine binding site [chemical binding]; other site 65393002207 Cytochrome c; Region: Cytochrom_C; cl11414 65393002208 MAPEG family; Region: MAPEG; cl09190 65393002209 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 65393002210 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 65393002211 putative active site [active] 65393002212 substrate binding site [chemical binding]; other site 65393002213 putative cosubstrate binding site; other site 65393002214 catalytic site [active] 65393002215 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 65393002216 substrate binding site [chemical binding]; other site 65393002217 Cobalt transport protein; Region: CbiQ; cl00463 65393002218 GTP-binding protein Der; Reviewed; Region: PRK00093 65393002219 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 65393002220 G1 box; other site 65393002221 GTP/Mg2+ binding site [chemical binding]; other site 65393002222 Switch I region; other site 65393002223 G2 box; other site 65393002224 Switch II region; other site 65393002225 G3 box; other site 65393002226 G4 box; other site 65393002227 G5 box; other site 65393002228 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 65393002229 G1 box; other site 65393002230 GTP/Mg2+ binding site [chemical binding]; other site 65393002231 Switch I region; other site 65393002232 G2 box; other site 65393002233 G3 box; other site 65393002234 Switch II region; other site 65393002235 G4 box; other site 65393002236 G5 box; other site 65393002237 YCII-related domain; Region: YCII; cl00999 65393002238 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 65393002239 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 65393002240 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 65393002241 THUMP domain; Region: THUMP; cl12076 65393002242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393002243 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393002244 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393002245 putative active site [active] 65393002246 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 65393002247 active site residue [active] 65393002248 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 65393002249 G-X-X-G motif; other site 65393002250 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 65393002251 RxxxH motif; other site 65393002252 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 65393002253 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 65393002254 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 65393002255 Ribonuclease P; Region: Ribonuclease_P; cl00457 65393002256 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 65393002257 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 65393002258 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 65393002259 motif 1; other site 65393002260 active site 65393002261 motif 2; other site 65393002262 motif 3; other site 65393002263 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 65393002264 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 65393002265 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 65393002266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393002267 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 65393002268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393002269 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 65393002270 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 65393002271 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 65393002272 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 65393002273 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 65393002274 RNA binding surface [nucleotide binding]; other site 65393002275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393002276 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 65393002277 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 65393002278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393002279 S-adenosylmethionine binding site [chemical binding]; other site 65393002280 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 65393002281 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 65393002282 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 65393002283 metal binding site [ion binding]; metal-binding site 65393002284 dimer interface [polypeptide binding]; other site 65393002285 Flavin Reductases; Region: FlaRed; cl00801 65393002286 O-succinylbenzoate synthase; Provisional; Region: PRK02714 65393002287 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 65393002288 active site 65393002289 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393002290 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 65393002291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393002292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393002293 active site 65393002294 phosphorylation site [posttranslational modification] 65393002295 intermolecular recognition site; other site 65393002296 dimerization interface [polypeptide binding]; other site 65393002297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393002298 DNA binding site [nucleotide binding] 65393002299 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 65393002300 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 65393002301 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 65393002302 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 65393002303 FtsX-like permease family; Region: FtsX; pfam02687 65393002304 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 65393002305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002306 binding surface 65393002307 TPR motif; other site 65393002308 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 65393002309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002310 binding surface 65393002311 TPR motif; other site 65393002312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002313 binding surface 65393002314 TPR motif; other site 65393002315 Response regulator receiver domain; Region: Response_reg; pfam00072 65393002316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393002317 active site 65393002318 phosphorylation site [posttranslational modification] 65393002319 intermolecular recognition site; other site 65393002320 dimerization interface [polypeptide binding]; other site 65393002321 DNA gyrase subunit A; Validated; Region: PRK05560 65393002322 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 65393002323 CAP-like domain; other site 65393002324 active site 65393002325 primary dimer interface [polypeptide binding]; other site 65393002326 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 65393002327 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 65393002328 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 65393002329 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 65393002330 putative active site [active] 65393002331 Cupin domain; Region: Cupin_2; cl09118 65393002332 Helix-turn-helix domains; Region: HTH; cl00088 65393002333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002334 binding surface 65393002335 TPR motif; other site 65393002336 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 65393002337 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 65393002338 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 65393002339 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393002340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393002341 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 65393002342 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 65393002343 catalytic residues [active] 65393002344 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 65393002345 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393002346 Protein kinase domain; Region: Pkinase; pfam00069 65393002347 active site 65393002348 ATP binding site [chemical binding]; other site 65393002349 substrate binding site [chemical binding]; other site 65393002350 activation loop (A-loop); other site 65393002351 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 65393002352 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 65393002353 putative ligand binding site [chemical binding]; other site 65393002354 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393002355 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393002356 active site 65393002357 ATP binding site [chemical binding]; other site 65393002358 substrate binding site [chemical binding]; other site 65393002359 activation loop (A-loop); other site 65393002360 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 65393002361 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 65393002362 Protein kinase domain; Region: Pkinase; pfam00069 65393002363 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393002364 active site 65393002365 ATP binding site [chemical binding]; other site 65393002366 substrate binding site [chemical binding]; other site 65393002367 activation loop (A-loop); other site 65393002368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 65393002369 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 65393002370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 65393002371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 65393002372 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 65393002373 Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948 65393002374 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 65393002375 active site 65393002376 catalytic residues [active] 65393002377 metal binding site [ion binding]; metal-binding site 65393002378 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 65393002379 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 65393002380 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393002381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393002382 active site 65393002383 phosphorylation site [posttranslational modification] 65393002384 intermolecular recognition site; other site 65393002385 dimerization interface [polypeptide binding]; other site 65393002386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393002387 DNA binding site [nucleotide binding] 65393002388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393002389 dimer interface [polypeptide binding]; other site 65393002390 phosphorylation site [posttranslational modification] 65393002391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393002392 ATP binding site [chemical binding]; other site 65393002393 Mg2+ binding site [ion binding]; other site 65393002394 G-X-G motif; other site 65393002395 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 65393002396 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 65393002397 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 65393002398 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 65393002399 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 65393002400 putative dimer interface [polypeptide binding]; other site 65393002401 N-terminal domain interface [polypeptide binding]; other site 65393002402 putative substrate binding pocket (H-site) [chemical binding]; other site 65393002403 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393002404 putative active site [active] 65393002405 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 65393002406 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 65393002407 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 65393002408 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 65393002409 dimer interface [polypeptide binding]; other site 65393002410 active site 65393002411 catalytic residue [active] 65393002412 metal binding site [ion binding]; metal-binding site 65393002413 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 65393002414 metal binding site [ion binding]; metal-binding site 65393002415 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 65393002416 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 65393002417 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393002418 putative active site [active] 65393002419 Bacterial SH3 domain; Region: SH3_3; cl02551 65393002420 Ycf46; Provisional; Region: ycf46; CHL00195 65393002421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393002422 Walker A motif; other site 65393002423 ATP binding site [chemical binding]; other site 65393002424 Walker B motif; other site 65393002425 arginine finger; other site 65393002426 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 65393002427 pheophorbide a oxygenase; Region: PLN02518 65393002428 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 65393002429 iron-sulfur cluster [ion binding]; other site 65393002430 [2Fe-2S] cluster binding site [ion binding]; other site 65393002431 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 65393002432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393002433 S-adenosylmethionine binding site [chemical binding]; other site 65393002434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393002435 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 65393002436 oligomerization interface [polypeptide binding]; other site 65393002437 active site 65393002438 metal binding site [ion binding]; metal-binding site 65393002439 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 65393002440 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 65393002441 putative active site [active] 65393002442 putative NTP binding site [chemical binding]; other site 65393002443 putative nucleic acid binding site [nucleotide binding]; other site 65393002444 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 65393002445 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 65393002446 active site 65393002447 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 65393002448 putative active site [active] 65393002449 putative NTP binding site [chemical binding]; other site 65393002450 putative nucleic acid binding site [nucleotide binding]; other site 65393002451 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 65393002452 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 65393002453 DNA binding residues [nucleotide binding] 65393002454 putative dimer interface [polypeptide binding]; other site 65393002455 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 65393002456 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 65393002457 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 65393002458 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393002459 Integrase core domain; Region: rve; cl01316 65393002460 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 65393002461 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 65393002462 trimer interface [polypeptide binding]; other site 65393002463 dimer interface [polypeptide binding]; other site 65393002464 putative active site [active] 65393002465 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 65393002466 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 65393002467 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 65393002468 nudix motif; other site 65393002469 Response regulator receiver domain; Region: Response_reg; pfam00072 65393002470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393002471 active site 65393002472 phosphorylation site [posttranslational modification] 65393002473 intermolecular recognition site; other site 65393002474 dimerization interface [polypeptide binding]; other site 65393002475 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 65393002476 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393002477 metal binding site [ion binding]; metal-binding site 65393002478 active site 65393002479 I-site; other site 65393002480 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 65393002481 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 65393002482 Walker A/P-loop; other site 65393002483 ATP binding site [chemical binding]; other site 65393002484 Q-loop/lid; other site 65393002485 ABC transporter signature motif; other site 65393002486 Walker B; other site 65393002487 D-loop; other site 65393002488 H-loop/switch region; other site 65393002489 Response regulator receiver domain; Region: Response_reg; pfam00072 65393002490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393002491 active site 65393002492 phosphorylation site [posttranslational modification] 65393002493 intermolecular recognition site; other site 65393002494 dimerization interface [polypeptide binding]; other site 65393002495 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 65393002496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393002497 active site 65393002498 phosphorylation site [posttranslational modification] 65393002499 intermolecular recognition site; other site 65393002500 ParB-like nuclease domain; Region: ParBc; cl02129 65393002501 Helix-turn-helix domains; Region: HTH; cl00088 65393002502 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 65393002503 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 65393002504 Phosphotransferase enzyme family; Region: APH; pfam01636 65393002505 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 65393002506 active site 65393002507 ATP binding site [chemical binding]; other site 65393002508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393002509 Coenzyme A binding pocket [chemical binding]; other site 65393002510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 65393002511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393002512 dimer interface [polypeptide binding]; other site 65393002513 phosphorylation site [posttranslational modification] 65393002514 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 65393002515 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 65393002516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002517 binding surface 65393002518 TPR motif; other site 65393002519 Protein of unknown function DUF86; Region: DUF86; cl01031 65393002520 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393002521 active site 65393002522 NTP binding site [chemical binding]; other site 65393002523 metal binding triad [ion binding]; metal-binding site 65393002524 antibiotic binding site [chemical binding]; other site 65393002525 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 65393002526 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 65393002527 DNA binding residues [nucleotide binding] 65393002528 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 65393002529 catalytic residues [active] 65393002530 catalytic nucleophile [active] 65393002531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393002532 Probable transposase; Region: OrfB_IS605; pfam01385 65393002533 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393002534 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393002535 Proline dehydrogenase; Region: Pro_dh; cl03282 65393002536 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 65393002537 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 65393002538 Glutamate binding site [chemical binding]; other site 65393002539 homodimer interface [polypeptide binding]; other site 65393002540 NAD binding site [chemical binding]; other site 65393002541 catalytic residues [active] 65393002542 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 65393002543 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 65393002544 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 65393002545 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 65393002546 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 65393002547 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 65393002548 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 65393002549 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 65393002550 putative nucleic acid binding region [nucleotide binding]; other site 65393002551 G-X-X-G motif; other site 65393002552 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 65393002553 RNA binding site [nucleotide binding]; other site 65393002554 domain interface; other site 65393002555 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 65393002556 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 65393002557 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 65393002558 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393002559 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393002560 active site 65393002561 ATP binding site [chemical binding]; other site 65393002562 substrate binding site [chemical binding]; other site 65393002563 activation loop (A-loop); other site 65393002564 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393002565 Ligand Binding Site [chemical binding]; other site 65393002566 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393002567 Ligand Binding Site [chemical binding]; other site 65393002568 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 65393002569 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 65393002570 RNA/DNA binding site [nucleotide binding]; other site 65393002571 RRM dimerization site [polypeptide binding]; other site 65393002572 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 65393002573 tetramer (dimer of dimers) interface [polypeptide binding]; other site 65393002574 active site 65393002575 dimer interface [polypeptide binding]; other site 65393002576 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 65393002577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393002578 Coenzyme A binding pocket [chemical binding]; other site 65393002579 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 65393002580 L11 interface [polypeptide binding]; other site 65393002581 putative EF-Tu interaction site [polypeptide binding]; other site 65393002582 putative EF-G interaction site [polypeptide binding]; other site 65393002583 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 65393002584 23S rRNA interface [nucleotide binding]; other site 65393002585 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 65393002586 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 65393002587 mRNA/rRNA interface [nucleotide binding]; other site 65393002588 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 65393002589 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 65393002590 23S rRNA interface [nucleotide binding]; other site 65393002591 L7/L12 interface [polypeptide binding]; other site 65393002592 putative thiostrepton binding site; other site 65393002593 L25 interface [polypeptide binding]; other site 65393002594 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 65393002595 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 65393002596 putative homodimer interface [polypeptide binding]; other site 65393002597 KOW motif; Region: KOW; cl00354 65393002598 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 65393002599 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 65393002600 Integral membrane protein TerC family; Region: TerC; cl10468 65393002601 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002602 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002603 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393002604 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002606 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002607 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002608 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002609 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 65393002610 Protein export membrane protein; Region: SecD_SecF; cl14618 65393002611 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 65393002612 Protein export membrane protein; Region: SecD_SecF; cl14618 65393002613 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 65393002614 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 65393002615 alpha subunit interface [polypeptide binding]; other site 65393002616 TPP binding site [chemical binding]; other site 65393002617 heterodimer interface [polypeptide binding]; other site 65393002618 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 65393002619 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 65393002620 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 65393002621 MOSC domain; Region: MOSC; pfam03473 65393002622 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 65393002623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393002624 ATP binding site [chemical binding]; other site 65393002625 putative Mg++ binding site [ion binding]; other site 65393002626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393002627 nucleotide binding region [chemical binding]; other site 65393002628 ATP-binding site [chemical binding]; other site 65393002629 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 65393002630 PetN; Region: PetN; cl15376 65393002631 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 65393002632 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393002633 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 65393002634 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 65393002635 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 65393002636 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 65393002637 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 65393002638 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 65393002639 dimer interface [polypeptide binding]; other site 65393002640 active site 65393002641 CoA binding pocket [chemical binding]; other site 65393002642 Acyl transferase domain; Region: Acyl_transf_1; cl08282 65393002643 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 65393002644 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 65393002645 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 65393002646 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 65393002647 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 65393002648 protein I interface; other site 65393002649 D2 interface; other site 65393002650 protein T interface; other site 65393002651 chlorophyll binding site; other site 65393002652 beta carotene binding site; other site 65393002653 pheophytin binding site; other site 65393002654 manganese-stabilizing polypeptide interface; other site 65393002655 CP43 interface; other site 65393002656 protein L interface; other site 65393002657 oxygen evolving complex binding site; other site 65393002658 bromide binding site; other site 65393002659 quinone binding site; other site 65393002660 Fe binding site [ion binding]; other site 65393002661 core light harvesting interface; other site 65393002662 cytochrome b559 alpha subunit interface; other site 65393002663 cytochrome c-550 interface; other site 65393002664 protein J interface; other site 65393002665 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393002666 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393002667 putative active site [active] 65393002668 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 65393002669 GUN4-like; Region: GUN4; pfam05419 65393002670 Phd_YefM; Region: PhdYeFM; cl09153 65393002671 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 65393002672 putative active site [active] 65393002673 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 65393002674 short chain dehydrogenase; Provisional; Region: PRK06701 65393002675 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 65393002676 NAD binding site [chemical binding]; other site 65393002677 metal binding site [ion binding]; metal-binding site 65393002678 active site 65393002679 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 65393002680 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 65393002681 homodimer interface [polypeptide binding]; other site 65393002682 Walker A motif; other site 65393002683 ATP binding site [chemical binding]; other site 65393002684 hydroxycobalamin binding site [chemical binding]; other site 65393002685 Walker B motif; other site 65393002686 TIGR00268 family protein; Region: TIGR00268 65393002687 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 65393002688 Ligand Binding Site [chemical binding]; other site 65393002689 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 65393002690 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 65393002691 Surface antigen; Region: Bac_surface_Ag; cl03097 65393002692 haemagglutination activity domain; Region: Haemagg_act; cl05436 65393002693 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 65393002694 CHAT domain; Region: CHAT; cl02083 65393002695 Protein of unknown function (DUF952); Region: DUF952; cl01393 65393002696 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 65393002697 GAF domain; Region: GAF; cl00853 65393002698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393002699 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 65393002700 MgtC family; Region: MgtC; cl12207 65393002701 Dam-replacing family; Region: DRP; pfam06044 65393002702 Ferritin-like domain; Region: Ferritin; pfam00210 65393002703 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 65393002704 dimerization interface [polypeptide binding]; other site 65393002705 DPS ferroxidase diiron center [ion binding]; other site 65393002706 ion pore; other site 65393002707 ChaB; Region: ChaB; cl01887 65393002708 Domain of unknown function DUF20; Region: UPF0118; cl00465 65393002709 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 65393002710 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 65393002711 homoserine kinase; Provisional; Region: PRK01212 65393002712 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 65393002713 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 65393002714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393002715 PAS fold; Region: PAS_3; pfam08447 65393002716 putative active site [active] 65393002717 heme pocket [chemical binding]; other site 65393002718 PAS fold; Region: PAS_4; pfam08448 65393002719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393002720 putative active site [active] 65393002721 heme pocket [chemical binding]; other site 65393002722 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393002723 GAF domain; Region: GAF; cl00853 65393002724 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 65393002725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393002726 putative active site [active] 65393002727 heme pocket [chemical binding]; other site 65393002728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393002729 dimer interface [polypeptide binding]; other site 65393002730 phosphorylation site [posttranslational modification] 65393002731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393002732 ATP binding site [chemical binding]; other site 65393002733 Mg2+ binding site [ion binding]; other site 65393002734 G-X-G motif; other site 65393002735 Response regulator receiver domain; Region: Response_reg; pfam00072 65393002736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393002737 active site 65393002738 phosphorylation site [posttranslational modification] 65393002739 intermolecular recognition site; other site 65393002740 dimerization interface [polypeptide binding]; other site 65393002741 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 65393002742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393002743 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 65393002744 putative active site [active] 65393002745 heme pocket [chemical binding]; other site 65393002746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393002747 putative active site [active] 65393002748 heme pocket [chemical binding]; other site 65393002749 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393002750 metal binding site [ion binding]; metal-binding site 65393002751 active site 65393002752 I-site; other site 65393002753 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393002754 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 65393002755 RNA/DNA binding site [nucleotide binding]; other site 65393002756 RRM dimerization site [polypeptide binding]; other site 65393002757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002758 TPR motif; other site 65393002759 binding surface 65393002760 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 65393002761 catalytic loop [active] 65393002762 iron binding site [ion binding]; other site 65393002763 Phycobilisome protein; Region: Phycobilisome; cl08227 65393002764 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 65393002765 catalytic loop [active] 65393002766 iron binding site [ion binding]; other site 65393002767 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 65393002768 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 65393002769 Heme NO binding; Region: HNOB; cl15268 65393002770 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 65393002771 Heme NO binding; Region: HNOB; cl15268 65393002772 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 65393002773 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 65393002774 putative NAD(P) binding site [chemical binding]; other site 65393002775 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 65393002776 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 65393002777 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 65393002778 active site clefts [active] 65393002779 zinc binding site [ion binding]; other site 65393002780 dimer interface [polypeptide binding]; other site 65393002781 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 65393002782 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 65393002783 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 65393002784 Fasciclin domain; Region: Fasciclin; cl02663 65393002785 EamA-like transporter family; Region: EamA; cl01037 65393002786 EamA-like transporter family; Region: EamA; cl01037 65393002787 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 65393002788 lipoyl synthase; Provisional; Region: PRK12928 65393002789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393002790 FeS/SAM binding site; other site 65393002791 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 65393002792 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 65393002793 TM-ABC transporter signature motif; other site 65393002794 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 65393002795 FOG: CBS domain [General function prediction only]; Region: COG0517 65393002796 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 65393002797 FOG: CBS domain [General function prediction only]; Region: COG0517 65393002798 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 65393002799 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 65393002800 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393002801 GAF domain; Region: GAF; cl00853 65393002802 Histidine kinase; Region: HisKA_2; cl06527 65393002803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393002804 ATP binding site [chemical binding]; other site 65393002805 Mg2+ binding site [ion binding]; other site 65393002806 G-X-G motif; other site 65393002807 Response regulator receiver domain; Region: Response_reg; pfam00072 65393002808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393002809 active site 65393002810 phosphorylation site [posttranslational modification] 65393002811 intermolecular recognition site; other site 65393002812 dimerization interface [polypeptide binding]; other site 65393002813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393002814 dimer interface [polypeptide binding]; other site 65393002815 phosphorylation site [posttranslational modification] 65393002816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393002817 ATP binding site [chemical binding]; other site 65393002818 Mg2+ binding site [ion binding]; other site 65393002819 G-X-G motif; other site 65393002820 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002821 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002822 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393002823 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 65393002824 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393002825 GTP-binding protein LepA; Provisional; Region: PRK05433 65393002826 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 65393002827 G1 box; other site 65393002828 putative GEF interaction site [polypeptide binding]; other site 65393002829 GTP/Mg2+ binding site [chemical binding]; other site 65393002830 Switch I region; other site 65393002831 G2 box; other site 65393002832 G3 box; other site 65393002833 Switch II region; other site 65393002834 G4 box; other site 65393002835 G5 box; other site 65393002836 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 65393002837 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 65393002838 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 65393002839 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393002840 GAF domain; Region: GAF; cl00853 65393002841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393002842 dimer interface [polypeptide binding]; other site 65393002843 phosphorylation site [posttranslational modification] 65393002844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393002845 ATP binding site [chemical binding]; other site 65393002846 Mg2+ binding site [ion binding]; other site 65393002847 G-X-G motif; other site 65393002848 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393002849 S-layer homology domain; Region: SLH; pfam00395 65393002850 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 65393002851 nucleoside/Zn binding site; other site 65393002852 dimer interface [polypeptide binding]; other site 65393002853 catalytic motif [active] 65393002854 2-isopropylmalate synthase; Validated; Region: PRK00915 65393002855 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 65393002856 active site 65393002857 catalytic residues [active] 65393002858 metal binding site [ion binding]; metal-binding site 65393002859 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 65393002860 Maf-like protein; Region: Maf; pfam02545 65393002861 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 65393002862 active site 65393002863 dimer interface [polypeptide binding]; other site 65393002864 PsbP; Region: PsbP; cl03356 65393002865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002866 binding surface 65393002867 TPR motif; other site 65393002868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002869 binding surface 65393002870 TPR motif; other site 65393002871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393002872 binding surface 65393002873 TPR motif; other site 65393002874 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 65393002875 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393002876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393002877 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393002878 TIR domain; Region: TIR; cl02060 65393002879 Haemolysin XhlA; Region: XhlA; pfam10779 65393002880 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 65393002881 Baseplate J-like protein; Region: Baseplate_J; cl01294 65393002882 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 65393002883 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 65393002884 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 65393002885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393002886 dimer interface [polypeptide binding]; other site 65393002887 phosphorylation site [posttranslational modification] 65393002888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393002889 ATP binding site [chemical binding]; other site 65393002890 Mg2+ binding site [ion binding]; other site 65393002891 G-X-G motif; other site 65393002892 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393002893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393002894 active site 65393002895 phosphorylation site [posttranslational modification] 65393002896 intermolecular recognition site; other site 65393002897 dimerization interface [polypeptide binding]; other site 65393002898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393002899 DNA binding site [nucleotide binding] 65393002900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 65393002901 Domain of unknown function (DUF305); Region: DUF305; pfam03713 65393002902 Domain of unknown function (DUF305); Region: DUF305; pfam03713 65393002903 Predicted integral membrane protein [Function unknown]; Region: COG0392 65393002904 maltose O-acetyltransferase; Provisional; Region: PRK10092 65393002905 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 65393002906 active site 65393002907 substrate binding site [chemical binding]; other site 65393002908 trimer interface [polypeptide binding]; other site 65393002909 CoA binding site [chemical binding]; other site 65393002910 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 65393002911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 65393002912 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 65393002913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 65393002914 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393002915 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 65393002916 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 65393002917 generic binding surface II; other site 65393002918 ssDNA binding site; other site 65393002919 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393002920 ATP binding site [chemical binding]; other site 65393002921 putative Mg++ binding site [ion binding]; other site 65393002922 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393002923 nucleotide binding region [chemical binding]; other site 65393002924 ATP-binding site [chemical binding]; other site 65393002925 elongation factor Ts; Reviewed; Region: tsf; PRK12332 65393002926 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 65393002927 Elongation factor TS; Region: EF_TS; pfam00889 65393002928 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 65393002929 rRNA interaction site [nucleotide binding]; other site 65393002930 S8 interaction site; other site 65393002931 putative laminin-1 binding site; other site 65393002932 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 65393002933 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 65393002934 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393002935 FeS/SAM binding site; other site 65393002936 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 65393002937 lipoyl attachment site [posttranslational modification]; other site 65393002938 Uncharacterized conserved protein [Function unknown]; Region: COG3349 65393002939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393002940 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 65393002941 active site lid residues [active] 65393002942 substrate binding pocket [chemical binding]; other site 65393002943 catalytic residues [active] 65393002944 substrate-Mg2+ binding site; other site 65393002945 aspartate-rich region 1; other site 65393002946 aspartate-rich region 2; other site 65393002947 UbiA prenyltransferase family; Region: UbiA; cl00337 65393002948 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 65393002949 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 65393002950 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 65393002951 active site residue [active] 65393002952 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 65393002953 HrcA protein C terminal domain; Region: HrcA; pfam01628 65393002954 Helix-turn-helix domains; Region: HTH; cl00088 65393002955 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 65393002956 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 65393002957 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 65393002958 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 65393002959 Protein export membrane protein; Region: SecD_SecF; cl14618 65393002960 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 65393002961 Predicted ATPase [General function prediction only]; Region: COG3899 65393002962 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393002963 structural tetrad; other site 65393002964 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393002965 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393002966 structural tetrad; other site 65393002967 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393002968 structural tetrad; other site 65393002969 TIR domain; Region: TIR; cl02060 65393002970 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393002971 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 65393002972 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393002973 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 65393002974 putative acyl-acceptor binding pocket; other site 65393002975 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 65393002976 RNA methyltransferase, RsmE family; Region: TIGR00046 65393002977 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 65393002978 putative acyl transferase; Provisional; Region: PRK10502 65393002979 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 65393002980 putative trimer interface [polypeptide binding]; other site 65393002981 putative active site [active] 65393002982 putative substrate binding site [chemical binding]; other site 65393002983 putative CoA binding site [chemical binding]; other site 65393002984 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 65393002985 homotrimer interface [polypeptide binding]; other site 65393002986 Walker A motif; other site 65393002987 GTP binding site [chemical binding]; other site 65393002988 Walker B motif; other site 65393002989 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393002990 UGMP family protein; Validated; Region: PRK09604 65393002991 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 65393002992 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 65393002993 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 65393002994 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 65393002995 active site 65393002996 catalytic tetrad [active] 65393002997 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 65393002998 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 65393002999 CheB methylesterase; Region: CheB_methylest; pfam01339 65393003000 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 65393003001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393003002 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 65393003003 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 65393003004 PemK-like protein; Region: PemK; cl00995 65393003005 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 65393003006 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 65393003007 Malic enzyme, N-terminal domain; Region: malic; pfam00390 65393003008 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 65393003009 putative NAD(P) binding site [chemical binding]; other site 65393003010 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 65393003011 SWIM zinc finger; Region: SWIM; cl15408 65393003012 Domain of unknown function DUF; Region: DUF202; cl09954 65393003013 Domain of unknown function DUF; Region: DUF202; cl09954 65393003014 Domain of unknown function DUF; Region: DUF202; cl09954 65393003015 Membrane transport protein; Region: Mem_trans; cl09117 65393003016 MarC family integral membrane protein; Region: MarC; cl00919 65393003017 Sulfatase; Region: Sulfatase; cl10460 65393003018 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 65393003019 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393003020 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 65393003021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 65393003022 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 65393003023 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393003024 putative active site [active] 65393003025 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 65393003026 RNA binding site [nucleotide binding]; other site 65393003027 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 65393003028 RNA binding site [nucleotide binding]; other site 65393003029 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 65393003030 RNA binding site [nucleotide binding]; other site 65393003031 Dienelactone hydrolase family; Region: DLH; pfam01738 65393003032 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 65393003033 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 65393003034 dimerization interface [polypeptide binding]; other site 65393003035 active site 65393003036 dihydroorotase; Validated; Region: pyrC; PRK09357 65393003037 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 65393003038 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 65393003039 active site 65393003040 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 65393003041 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 65393003042 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 65393003043 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 65393003044 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 65393003045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393003046 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 65393003047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393003048 Walker A/P-loop; other site 65393003049 ATP binding site [chemical binding]; other site 65393003050 Q-loop/lid; other site 65393003051 ABC transporter signature motif; other site 65393003052 Walker B; other site 65393003053 D-loop; other site 65393003054 H-loop/switch region; other site 65393003055 TOBE domain; Region: TOBE_2; cl01440 65393003056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393003057 dimer interface [polypeptide binding]; other site 65393003058 ABC-ATPase subunit interface; other site 65393003059 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 65393003060 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 65393003061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393003062 Probable transposase; Region: OrfB_IS605; pfam01385 65393003063 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393003064 glycogen branching enzyme; Provisional; Region: PRK05402 65393003065 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 65393003066 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 65393003067 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 65393003068 active site 65393003069 catalytic site [active] 65393003070 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 65393003071 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 65393003072 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 65393003073 substrate binding pocket [chemical binding]; other site 65393003074 chain length determination region; other site 65393003075 substrate-Mg2+ binding site; other site 65393003076 catalytic residues [active] 65393003077 aspartate-rich region 1; other site 65393003078 active site lid residues [active] 65393003079 aspartate-rich region 2; other site 65393003080 Exoribonuclease R [Transcription]; Region: VacB; COG0557 65393003081 RNB domain; Region: RNB; pfam00773 65393003082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393003083 S-adenosylmethionine binding site [chemical binding]; other site 65393003084 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393003085 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393003086 structural tetrad; other site 65393003087 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393003088 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393003089 structural tetrad; other site 65393003090 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 65393003091 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 65393003092 [2Fe-2S] cluster binding site [ion binding]; other site 65393003093 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 65393003094 hydrophobic ligand binding site; other site 65393003095 UbiA prenyltransferase family; Region: UbiA; cl00337 65393003096 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 65393003097 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 65393003098 P loop; other site 65393003099 Nucleotide binding site [chemical binding]; other site 65393003100 DTAP/Switch II; other site 65393003101 Switch I; other site 65393003102 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 65393003103 ABC-2 type transporter; Region: ABC2_membrane; cl11417 65393003104 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 65393003105 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 65393003106 Walker A/P-loop; other site 65393003107 ATP binding site [chemical binding]; other site 65393003108 Q-loop/lid; other site 65393003109 ABC transporter signature motif; other site 65393003110 Walker B; other site 65393003111 D-loop; other site 65393003112 H-loop/switch region; other site 65393003113 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393003114 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393003115 hypothetical protein; Provisional; Region: PHA03169 65393003116 hypothetical protein; Provisional; Region: PHA03169 65393003117 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393003118 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393003119 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393003120 Uncharacterized conserved protein [Function unknown]; Region: COG5464 65393003121 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 65393003122 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393003123 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393003124 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393003125 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393003126 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393003127 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 65393003128 putative ADP-binding pocket [chemical binding]; other site 65393003129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 65393003130 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 65393003131 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393003132 active site 65393003133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393003134 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 65393003135 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 65393003136 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 65393003137 Probable Catalytic site; other site 65393003138 metal-binding site 65393003139 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 65393003140 Probable Catalytic site; other site 65393003141 metal-binding site 65393003142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393003143 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 65393003144 putative ADP-binding pocket [chemical binding]; other site 65393003145 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 65393003146 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 65393003147 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 65393003148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003149 binding surface 65393003150 TPR motif; other site 65393003151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003152 binding surface 65393003153 TPR motif; other site 65393003154 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 65393003155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393003156 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 65393003157 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393003158 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393003159 active site 65393003160 ATP binding site [chemical binding]; other site 65393003161 substrate binding site [chemical binding]; other site 65393003162 activation loop (A-loop); other site 65393003163 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 65393003164 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393003165 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393003166 active site 65393003167 ATP binding site [chemical binding]; other site 65393003168 substrate binding site [chemical binding]; other site 65393003169 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 65393003170 substrate binding site [chemical binding]; other site 65393003171 activation loop (A-loop); other site 65393003172 activation loop (A-loop); other site 65393003173 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 65393003174 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 65393003175 dimer interface [polypeptide binding]; other site 65393003176 PYR/PP interface [polypeptide binding]; other site 65393003177 TPP binding site [chemical binding]; other site 65393003178 substrate binding site [chemical binding]; other site 65393003179 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 65393003180 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 65393003181 Domain of unknown function; Region: EKR; cl11037 65393003182 4Fe-4S binding domain; Region: Fer4; cl02805 65393003183 4Fe-4S binding domain; Region: Fer4; cl02805 65393003184 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 65393003185 TPP-binding site [chemical binding]; other site 65393003186 dimer interface [polypeptide binding]; other site 65393003187 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 65393003188 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 65393003189 putative active site [active] 65393003190 putative FMN binding site [chemical binding]; other site 65393003191 putative substrate binding site [chemical binding]; other site 65393003192 6-phosphofructokinase; Provisional; Region: PRK03202 65393003193 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 65393003194 active site 65393003195 ADP/pyrophosphate binding site [chemical binding]; other site 65393003196 dimerization interface [polypeptide binding]; other site 65393003197 allosteric effector site; other site 65393003198 fructose-1,6-bisphosphate binding site; other site 65393003199 Hydrogenase formation hypA family; Region: HypD; cl12072 65393003200 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 65393003201 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 65393003202 active site 65393003203 hydrophilic channel; other site 65393003204 dimerization interface [polypeptide binding]; other site 65393003205 catalytic residues [active] 65393003206 active site lid [active] 65393003207 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 65393003208 Domain of unknown function (DUF897); Region: DUF897; cl01312 65393003209 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393003210 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 65393003211 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 65393003212 DNA binding residues [nucleotide binding] 65393003213 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 65393003214 catalytic residues [active] 65393003215 catalytic nucleophile [active] 65393003216 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 65393003217 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 65393003218 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393003219 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393003220 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393003221 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393003222 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 65393003223 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 65393003224 Walker A/P-loop; other site 65393003225 ATP binding site [chemical binding]; other site 65393003226 Q-loop/lid; other site 65393003227 ABC transporter signature motif; other site 65393003228 Walker B; other site 65393003229 D-loop; other site 65393003230 H-loop/switch region; other site 65393003231 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 65393003232 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 65393003233 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393003234 Walker A/P-loop; other site 65393003235 ATP binding site [chemical binding]; other site 65393003236 Q-loop/lid; other site 65393003237 ABC transporter signature motif; other site 65393003238 Walker B; other site 65393003239 D-loop; other site 65393003240 H-loop/switch region; other site 65393003241 TOBE domain; Region: TOBE_2; cl01440 65393003242 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 65393003243 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393003244 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393003245 polyphosphate kinase; Provisional; Region: PRK05443 65393003246 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 65393003247 putative domain interface [polypeptide binding]; other site 65393003248 putative active site [active] 65393003249 catalytic site [active] 65393003250 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 65393003251 putative domain interface [polypeptide binding]; other site 65393003252 putative active site [active] 65393003253 catalytic site [active] 65393003254 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 65393003255 metal ion-dependent adhesion site (MIDAS); other site 65393003256 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 65393003257 Protein of unknown function (DUF990); Region: DUF990; cl01496 65393003258 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 65393003259 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393003260 Walker A/P-loop; other site 65393003261 ATP binding site [chemical binding]; other site 65393003262 Q-loop/lid; other site 65393003263 ABC transporter signature motif; other site 65393003264 Walker B; other site 65393003265 D-loop; other site 65393003266 H-loop/switch region; other site 65393003267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393003268 PAS fold; Region: PAS_3; pfam08447 65393003269 putative active site [active] 65393003270 heme pocket [chemical binding]; other site 65393003271 PAS domain S-box; Region: sensory_box; TIGR00229 65393003272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393003273 putative active site [active] 65393003274 heme pocket [chemical binding]; other site 65393003275 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393003276 metal binding site [ion binding]; metal-binding site 65393003277 active site 65393003278 I-site; other site 65393003279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393003280 Peptidase family M48; Region: Peptidase_M48; cl12018 65393003281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003282 TPR motif; other site 65393003283 binding surface 65393003284 BAF1 / ABF1 chromatin reorganising factor; Region: BAF1_ABF1; pfam04684 65393003285 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 65393003286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003287 binding surface 65393003288 TPR motif; other site 65393003289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003290 binding surface 65393003291 TPR motif; other site 65393003292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003293 binding surface 65393003294 TPR motif; other site 65393003295 sulfotransferase; Region: PLN02164 65393003296 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393003297 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 65393003298 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 65393003299 active site 65393003300 HIGH motif; other site 65393003301 dimer interface [polypeptide binding]; other site 65393003302 KMSKS motif; other site 65393003303 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 65393003304 active site 65393003305 integral membrane protein MviN; Region: mviN; TIGR01695 65393003306 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 65393003307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393003308 dimer interface [polypeptide binding]; other site 65393003309 phosphorylation site [posttranslational modification] 65393003310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393003311 ATP binding site [chemical binding]; other site 65393003312 Mg2+ binding site [ion binding]; other site 65393003313 G-X-G motif; other site 65393003314 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 65393003315 photosystem II protein Psb27; Provisional; Region: PLN00064; cl11841 65393003316 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 65393003317 homotrimer interaction site [polypeptide binding]; other site 65393003318 putative active site [active] 65393003319 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 65393003320 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 65393003321 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 65393003322 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 65393003323 putative ligand binding site [chemical binding]; other site 65393003324 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 65393003325 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 65393003326 Ion channel; Region: Ion_trans_2; cl11596 65393003327 Late 100kD protein; Region: Adeno_100; pfam02438 65393003328 Protein of unknown function (DUF421); Region: DUF421; cl00990 65393003329 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 65393003330 LabA_like proteins; Region: LabA_like/DUF88; cl10034 65393003331 putative metal binding site [ion binding]; other site 65393003332 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 65393003333 Ligand Binding Site [chemical binding]; other site 65393003334 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393003335 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 65393003336 KamA family protein; Region: TIGR00238; cl15377 65393003337 Protein of function (DUF2518); Region: DUF2518; pfam10726 65393003338 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 65393003339 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 65393003340 putative active site [active] 65393003341 metal binding site [ion binding]; metal-binding site 65393003342 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 65393003343 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 65393003344 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 65393003345 G1 box; other site 65393003346 GTP/Mg2+ binding site [chemical binding]; other site 65393003347 Switch I region; other site 65393003348 G2 box; other site 65393003349 Switch II region; other site 65393003350 G3 box; other site 65393003351 G4 box; other site 65393003352 G5 box; other site 65393003353 Domain of unknown function (DUF697); Region: DUF697; cl12064 65393003354 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 65393003355 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 65393003356 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393003357 metal binding site [ion binding]; metal-binding site 65393003358 active site 65393003359 I-site; other site 65393003360 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 65393003361 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393003362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393003363 Probable transposase; Region: OrfB_IS605; pfam01385 65393003364 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393003365 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 65393003366 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393003367 OsmC-like protein; Region: OsmC; cl00767 65393003368 replicative DNA helicase; Region: DnaB; TIGR00665 65393003369 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 65393003370 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 65393003371 Walker A motif; other site 65393003372 ATP binding site [chemical binding]; other site 65393003373 Walker B motif; other site 65393003374 DNA binding loops [nucleotide binding] 65393003375 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 65393003376 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 65393003377 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 65393003378 DXD motif; other site 65393003379 PilZ domain; Region: PilZ; cl01260 65393003380 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393003381 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393003382 active site 65393003383 ATP binding site [chemical binding]; other site 65393003384 substrate binding site [chemical binding]; other site 65393003385 activation loop (A-loop); other site 65393003386 RDD family; Region: RDD; cl00746 65393003387 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393003388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393003389 active site 65393003390 phosphorylation site [posttranslational modification] 65393003391 intermolecular recognition site; other site 65393003392 dimerization interface [polypeptide binding]; other site 65393003393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393003394 DNA binding site [nucleotide binding] 65393003395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393003396 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393003397 Probable transposase; Region: OrfB_IS605; pfam01385 65393003398 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393003399 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393003400 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 65393003401 active site 65393003402 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 65393003403 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 65393003404 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 65393003405 Predicted integral membrane protein [Function unknown]; Region: COG5637 65393003406 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 65393003407 putative hydrophobic ligand binding site [chemical binding]; other site 65393003408 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 65393003409 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 65393003410 NAD binding site [chemical binding]; other site 65393003411 catalytic Zn binding site [ion binding]; other site 65393003412 structural Zn binding site [ion binding]; other site 65393003413 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 65393003414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393003415 S-adenosylmethionine binding site [chemical binding]; other site 65393003416 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 65393003417 MltA specific insert domain; Region: MltA; cl08398 65393003418 3D domain; Region: 3D; cl01439 65393003419 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393003420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003421 TPR motif; other site 65393003422 binding surface 65393003423 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 65393003424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003425 binding surface 65393003426 TPR motif; other site 65393003427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003428 binding surface 65393003429 TPR motif; other site 65393003430 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 65393003431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003432 binding surface 65393003433 TPR motif; other site 65393003434 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 65393003435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003436 binding surface 65393003437 TPR motif; other site 65393003438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003439 binding surface 65393003440 TPR motif; other site 65393003441 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 65393003442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003443 binding surface 65393003444 TPR motif; other site 65393003445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003446 binding surface 65393003447 TPR motif; other site 65393003448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393003449 binding surface 65393003450 TPR motif; other site 65393003451 CHAT domain; Region: CHAT; cl02083 65393003452 Protein of unknown function (DUF433); Region: DUF433; cl01030 65393003453 Protein of unknown function DUF82; Region: DUF82; pfam01927 65393003454 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393003455 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 65393003456 multimerization interface [polypeptide binding]; other site 65393003457 RbcX protein; Region: RcbX; pfam02341 65393003458 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 65393003459 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 65393003460 homodimer interface [polypeptide binding]; other site 65393003461 active site 65393003462 heterodimer interface [polypeptide binding]; other site 65393003463 catalytic residue [active] 65393003464 metal binding site [ion binding]; metal-binding site 65393003465 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 65393003466 putative trimer interface [polypeptide binding]; other site 65393003467 putative CoA binding site [chemical binding]; other site 65393003468 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 65393003469 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 65393003470 trimer interface [polypeptide binding]; other site 65393003471 active site 65393003472 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 65393003473 putative multimerization interface [polypeptide binding]; other site 65393003474 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 65393003475 putative multimerization interface [polypeptide binding]; other site 65393003476 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 65393003477 putative multimerization interface [polypeptide binding]; other site 65393003478 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 65393003479 putative multimerization interface [polypeptide binding]; other site 65393003480 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 65393003481 Hexamer/Pentamer interface [polypeptide binding]; other site 65393003482 central pore; other site 65393003483 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 65393003484 Hexamer interface [polypeptide binding]; other site 65393003485 Hexagonal pore residue; other site 65393003486 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 65393003487 Hexamer interface [polypeptide binding]; other site 65393003488 Hexagonal pore residue; other site 65393003489 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 65393003490 Hexamer interface [polypeptide binding]; other site 65393003491 Hexagonal pore residue; other site 65393003492 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 65393003493 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 65393003494 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 65393003495 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 65393003496 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 65393003497 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 65393003498 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393003499 putative active site [active] 65393003500 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 65393003501 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393003502 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 65393003503 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 65393003504 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 65393003505 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 65393003506 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 65393003507 active site 65393003508 dimer interface [polypeptide binding]; other site 65393003509 motif 1; other site 65393003510 motif 2; other site 65393003511 motif 3; other site 65393003512 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 65393003513 anticodon binding site; other site 65393003514 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393003515 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393003516 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 65393003517 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 65393003518 Walker A/P-loop; other site 65393003519 ATP binding site [chemical binding]; other site 65393003520 Q-loop/lid; other site 65393003521 ABC transporter signature motif; other site 65393003522 Walker B; other site 65393003523 D-loop; other site 65393003524 H-loop/switch region; other site 65393003525 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 65393003526 RimM N-terminal domain; Region: RimM; pfam01782 65393003527 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 65393003528 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 65393003529 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 65393003530 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393003531 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 65393003532 Fe-S cluster binding site [ion binding]; other site 65393003533 active site 65393003534 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 65393003535 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 65393003536 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 65393003537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393003538 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 65393003539 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 65393003540 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 65393003541 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 65393003542 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 65393003543 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 65393003544 putative catalytic residues [active] 65393003545 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 65393003546 Domain of unknown function (DUF427); Region: DUF427; cl00998 65393003547 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 65393003548 CHASE2 domain; Region: CHASE2; cl01732 65393003549 cyclase homology domain; Region: CHD; cd07302 65393003550 nucleotidyl binding site; other site 65393003551 metal binding site [ion binding]; metal-binding site 65393003552 dimer interface [polypeptide binding]; other site 65393003553 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393003554 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393003555 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393003556 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 65393003557 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393003558 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393003559 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 65393003560 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 65393003561 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 65393003562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393003563 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393003564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393003565 DNA binding residues [nucleotide binding] 65393003566 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393003567 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 65393003568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393003569 active site 65393003570 phosphorylation site [posttranslational modification] 65393003571 intermolecular recognition site; other site 65393003572 dimerization interface [polypeptide binding]; other site 65393003573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393003574 DNA binding residues [nucleotide binding] 65393003575 dimerization interface [polypeptide binding]; other site 65393003576 PAS domain S-box; Region: sensory_box; TIGR00229 65393003577 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 65393003578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393003579 PAS fold; Region: PAS_3; pfam08447 65393003580 putative active site [active] 65393003581 heme pocket [chemical binding]; other site 65393003582 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 65393003583 PAS domain S-box; Region: sensory_box; TIGR00229 65393003584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393003585 putative active site [active] 65393003586 heme pocket [chemical binding]; other site 65393003587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393003588 dimer interface [polypeptide binding]; other site 65393003589 phosphorylation site [posttranslational modification] 65393003590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393003591 ATP binding site [chemical binding]; other site 65393003592 Mg2+ binding site [ion binding]; other site 65393003593 G-X-G motif; other site 65393003594 Response regulator receiver domain; Region: Response_reg; pfam00072 65393003595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393003596 active site 65393003597 phosphorylation site [posttranslational modification] 65393003598 intermolecular recognition site; other site 65393003599 dimerization interface [polypeptide binding]; other site 65393003600 Response regulator receiver domain; Region: Response_reg; pfam00072 65393003601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393003602 active site 65393003603 phosphorylation site [posttranslational modification] 65393003604 intermolecular recognition site; other site 65393003605 dimerization interface [polypeptide binding]; other site 65393003606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393003607 dimer interface [polypeptide binding]; other site 65393003608 phosphorylation site [posttranslational modification] 65393003609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393003610 ATP binding site [chemical binding]; other site 65393003611 Mg2+ binding site [ion binding]; other site 65393003612 G-X-G motif; other site 65393003613 Response regulator receiver domain; Region: Response_reg; pfam00072 65393003614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393003615 active site 65393003616 phosphorylation site [posttranslational modification] 65393003617 intermolecular recognition site; other site 65393003618 dimerization interface [polypeptide binding]; other site 65393003619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 65393003620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393003621 ATP binding site [chemical binding]; other site 65393003622 Mg2+ binding site [ion binding]; other site 65393003623 G-X-G motif; other site 65393003624 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 65393003625 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 65393003626 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 65393003627 active site 65393003628 dimer interface [polypeptide binding]; other site 65393003629 catalytic residue [active] 65393003630 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 65393003631 Ca2+ binding site [ion binding]; other site 65393003632 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 65393003633 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 65393003634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393003635 ATP binding site [chemical binding]; other site 65393003636 putative Mg++ binding site [ion binding]; other site 65393003637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393003638 nucleotide binding region [chemical binding]; other site 65393003639 ATP-binding site [chemical binding]; other site 65393003640 RQC domain; Region: RQC; cl09632 65393003641 HRDC domain; Region: HRDC; cl02578 65393003642 Helix-turn-helix domains; Region: HTH; cl00088 65393003643 DNA binding residues [nucleotide binding] 65393003644 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 65393003645 homooctamer interface [polypeptide binding]; other site 65393003646 active site 65393003647 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 65393003648 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393003649 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393003650 putative active site [active] 65393003651 FO synthase subunit 2; Reviewed; Region: PRK07360 65393003652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393003653 FeS/SAM binding site; other site 65393003654 magnesium chelatase subunit H; Provisional; Region: PRK12493 65393003655 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 65393003656 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 65393003657 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393003658 putative active site [active] 65393003659 CobD/Cbib protein; Region: CobD_Cbib; cl00561 65393003660 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 65393003661 Rrf2 family protein; Region: rrf2_super; TIGR00738 65393003662 Helix-turn-helix domains; Region: HTH; cl00088 65393003663 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 65393003664 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 65393003665 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 65393003666 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 65393003667 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 65393003668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393003669 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 65393003670 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393003671 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393003672 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 65393003673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393003674 Coenzyme A binding pocket [chemical binding]; other site 65393003675 Tic22-like family; Region: Tic22; cl04468 65393003676 Tic22-like family; Region: Tic22; cl04468 65393003677 Tic22-like family; Region: Tic22; cl04468 65393003678 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 65393003679 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 65393003680 putative valine binding site [chemical binding]; other site 65393003681 dimer interface [polypeptide binding]; other site 65393003682 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 65393003683 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393003684 GAF domain; Region: GAF; cl00853 65393003685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393003686 dimer interface [polypeptide binding]; other site 65393003687 phosphorylation site [posttranslational modification] 65393003688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393003689 ATP binding site [chemical binding]; other site 65393003690 Mg2+ binding site [ion binding]; other site 65393003691 G-X-G motif; other site 65393003692 Response regulator receiver domain; Region: Response_reg; pfam00072 65393003693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393003694 active site 65393003695 phosphorylation site [posttranslational modification] 65393003696 intermolecular recognition site; other site 65393003697 dimerization interface [polypeptide binding]; other site 65393003698 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 65393003699 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393003700 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 65393003701 Flavin Reductases; Region: FlaRed; cl00801 65393003702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 65393003703 non-specific DNA binding site [nucleotide binding]; other site 65393003704 salt bridge; other site 65393003705 sequence-specific DNA binding site [nucleotide binding]; other site 65393003706 Domain of unknown function (DUF955); Region: DUF955; cl01076 65393003707 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 65393003708 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 65393003709 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 65393003710 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 65393003711 active site 65393003712 dimer interface [polypeptide binding]; other site 65393003713 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 65393003714 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 65393003715 active site 65393003716 FMN binding site [chemical binding]; other site 65393003717 substrate binding site [chemical binding]; other site 65393003718 3Fe-4S cluster binding site [ion binding]; other site 65393003719 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 65393003720 domain interface; other site 65393003721 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393003722 Probable transposase; Region: OrfB_IS605; pfam01385 65393003723 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 65393003724 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 65393003725 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 65393003726 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 65393003727 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 65393003728 Protein of unknown function DUF111; Region: DUF111; cl03398 65393003729 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 65393003730 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393003731 FeS/SAM binding site; other site 65393003732 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 65393003733 secreted effector protein PipB2; Provisional; Region: PRK15196 65393003734 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393003735 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393003736 Helix-turn-helix domains; Region: HTH; cl00088 65393003737 LysR family transcriptional regulator; Provisional; Region: PRK14997 65393003738 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 65393003739 putative effector binding pocket; other site 65393003740 dimerization interface [polypeptide binding]; other site 65393003741 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 65393003742 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 65393003743 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 65393003744 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 65393003745 Cupin domain; Region: Cupin_2; cl09118 65393003746 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 65393003747 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 65393003748 NADP binding site [chemical binding]; other site 65393003749 active site 65393003750 putative substrate binding site [chemical binding]; other site 65393003751 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 65393003752 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 65393003753 substrate binding site; other site 65393003754 metal-binding site 65393003755 Oligomer interface; other site 65393003756 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 65393003757 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 65393003758 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 65393003759 NAD binding site [chemical binding]; other site 65393003760 substrate binding site [chemical binding]; other site 65393003761 homodimer interface [polypeptide binding]; other site 65393003762 active site 65393003763 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 65393003764 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 65393003765 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393003766 putative active site [active] 65393003767 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 65393003768 AMP binding site [chemical binding]; other site 65393003769 metal binding site [ion binding]; metal-binding site 65393003770 active site 65393003771 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 65393003772 putative active site [active] 65393003773 transaldolase; Provisional; Region: PRK03903 65393003774 catalytic residue [active] 65393003775 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 65393003776 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 65393003777 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 65393003778 opcA protein; Region: OpcA; TIGR00534 65393003779 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 65393003780 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 65393003781 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 65393003782 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393003783 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 65393003784 catalytic triad [active] 65393003785 S-layer homology domain; Region: SLH; pfam00395 65393003786 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 65393003787 cysteine synthase; Region: PLN02565 65393003788 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 65393003789 dimer interface [polypeptide binding]; other site 65393003790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393003791 catalytic residue [active] 65393003792 chaperone protein DnaJ; Provisional; Region: PRK14291 65393003793 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 65393003794 HSP70 interaction site [polypeptide binding]; other site 65393003795 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 65393003796 active site 65393003797 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 65393003798 active site 65393003799 Creatinine amidohydrolase; Region: Creatininase; cl00618 65393003800 TIR domain; Region: TIR; cl02060 65393003801 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393003802 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393003803 TIR domain; Region: TIR; cl02060 65393003804 TIR domain; Region: TIR; cl02060 65393003805 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393003806 structural tetrad; other site 65393003807 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393003808 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393003809 structural tetrad; other site 65393003810 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 65393003811 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 65393003812 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 65393003813 ScpA/B protein; Region: ScpA_ScpB; cl00598 65393003814 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 65393003815 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 65393003816 active site 65393003817 Substrate binding site; other site 65393003818 Mg++ binding site; other site 65393003819 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 65393003820 putative trimer interface [polypeptide binding]; other site 65393003821 putative CoA binding site [chemical binding]; other site 65393003822 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 65393003823 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 65393003824 RNA binding surface [nucleotide binding]; other site 65393003825 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 65393003826 active site 65393003827 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 65393003828 YCII-related domain; Region: YCII; cl00999 65393003829 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 65393003830 anti sigma factor interaction site; other site 65393003831 regulatory phosphorylation site [posttranslational modification]; other site 65393003832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 65393003833 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 65393003834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393003835 active site 65393003836 phosphorylation site [posttranslational modification] 65393003837 intermolecular recognition site; other site 65393003838 dimerization interface [polypeptide binding]; other site 65393003839 CheB methylesterase; Region: CheB_methylest; pfam01339 65393003840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393003841 active site 65393003842 phosphorylation site [posttranslational modification] 65393003843 intermolecular recognition site; other site 65393003844 dimerization interface [polypeptide binding]; other site 65393003845 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 65393003846 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 65393003847 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 65393003848 putative binding surface; other site 65393003849 active site 65393003850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393003851 ATP binding site [chemical binding]; other site 65393003852 Mg2+ binding site [ion binding]; other site 65393003853 G-X-G motif; other site 65393003854 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 65393003855 Response regulator receiver domain; Region: Response_reg; pfam00072 65393003856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393003857 active site 65393003858 phosphorylation site [posttranslational modification] 65393003859 intermolecular recognition site; other site 65393003860 dimerization interface [polypeptide binding]; other site 65393003861 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 65393003862 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 65393003863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393003864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393003865 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 65393003866 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393003867 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393003868 prolyl-tRNA synthetase; Provisional; Region: PRK09194 65393003869 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 65393003870 dimer interface [polypeptide binding]; other site 65393003871 motif 1; other site 65393003872 active site 65393003873 motif 2; other site 65393003874 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 65393003875 putative deacylase active site [active] 65393003876 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 65393003877 active site 65393003878 motif 3; other site 65393003879 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 65393003880 anticodon binding site; other site 65393003881 Late competence development protein ComFB; Region: ComFB; pfam10719 65393003882 Late competence development protein ComFB; Region: ComFB; pfam10719 65393003883 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 65393003884 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 65393003885 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 65393003886 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 65393003887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 65393003888 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 65393003889 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393003890 putative active site [active] 65393003891 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 65393003892 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 65393003893 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 65393003894 Cytochrome P450; Region: p450; cl12078 65393003895 Cytochrome P450; Region: p450; cl12078 65393003896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 65393003897 Transposase; Region: DDE_Tnp_ISL3; pfam01610 65393003898 Predicted methyltransferases [General function prediction only]; Region: COG0313 65393003899 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 65393003900 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 65393003901 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 65393003902 substrate binding site [chemical binding]; other site 65393003903 ATP binding site [chemical binding]; other site 65393003904 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 65393003905 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393003906 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393003907 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393003908 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 65393003909 active site 65393003910 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 65393003911 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 65393003912 GIY-YIG motif/motif A; other site 65393003913 active site 65393003914 catalytic site [active] 65393003915 putative DNA binding site [nucleotide binding]; other site 65393003916 metal binding site [ion binding]; metal-binding site 65393003917 UvrB/uvrC motif; Region: UVR; pfam02151 65393003918 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 65393003919 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 65393003920 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 65393003921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393003922 Walker A motif; other site 65393003923 ATP binding site [chemical binding]; other site 65393003924 Walker B motif; other site 65393003925 arginine finger; other site 65393003926 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 65393003927 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 65393003928 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 65393003929 substrate binding site [chemical binding]; other site 65393003930 glutamase interaction surface [polypeptide binding]; other site 65393003931 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 65393003932 catalytic triad [active] 65393003933 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 65393003934 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 65393003935 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 65393003936 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393003937 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 65393003938 protein binding site [polypeptide binding]; other site 65393003939 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393003940 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 65393003941 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 65393003942 NADP binding site [chemical binding]; other site 65393003943 active site 65393003944 putative substrate binding site [chemical binding]; other site 65393003945 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 65393003946 pheophytin binding site; other site 65393003947 chlorophyll binding site; other site 65393003948 quinone binding site; other site 65393003949 Fe binding site [ion binding]; other site 65393003950 TIR domain; Region: TIR; cl02060 65393003951 Restriction endonuclease; Region: Mrr_cat; cl00747 65393003952 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 65393003953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393003954 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 65393003955 ThiS interaction site; other site 65393003956 putative active site [active] 65393003957 tetramer interface [polypeptide binding]; other site 65393003958 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 65393003959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393003960 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 65393003961 Photosystem II protein; Region: PSII; cl08223 65393003962 Nitrogen regulatory protein P-II; Region: P-II; cl00412 65393003963 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 65393003964 active site 65393003965 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 65393003966 FemAB family; Region: FemAB; cl11444 65393003967 Protein of unknown function, DUF482; Region: DUF482; pfam04339 65393003968 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 65393003969 trehalose synthase; Region: treS_nterm; TIGR02456 65393003970 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 65393003971 active site 65393003972 catalytic site [active] 65393003973 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 65393003974 Bacterial SH3 domain; Region: SH3_3; cl02551 65393003975 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 65393003976 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 65393003977 putative substrate binding site [chemical binding]; other site 65393003978 putative ATP binding site [chemical binding]; other site 65393003979 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 65393003980 Phosphoglycerate kinase; Region: PGK; pfam00162 65393003981 substrate binding site [chemical binding]; other site 65393003982 hinge regions; other site 65393003983 ADP binding site [chemical binding]; other site 65393003984 catalytic site [active] 65393003985 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393003986 Ligand Binding Site [chemical binding]; other site 65393003987 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 65393003988 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 65393003989 GTP/Mg2+ binding site [chemical binding]; other site 65393003990 G4 box; other site 65393003991 G5 box; other site 65393003992 G1 box; other site 65393003993 Switch I region; other site 65393003994 G2 box; other site 65393003995 G3 box; other site 65393003996 Switch II region; other site 65393003997 TIR domain; Region: TIR; cl02060 65393003998 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393003999 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 65393004000 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 65393004001 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 65393004002 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393004003 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 65393004004 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 65393004005 putative catalytic site [active] 65393004006 putative metal binding site [ion binding]; other site 65393004007 putative phosphate binding site [ion binding]; other site 65393004008 Competence protein; Region: Competence; cl00471 65393004009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393004010 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 65393004011 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393004012 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 65393004013 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 65393004014 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 65393004015 NAD(P) binding site [chemical binding]; other site 65393004016 molecular chaperone DnaK; Provisional; Region: PRK13410 65393004017 chaperone protein DnaJ; Provisional; Region: PRK14299 65393004018 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 65393004019 HSP70 interaction site [polypeptide binding]; other site 65393004020 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 65393004021 dimer interface [polypeptide binding]; other site 65393004022 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 65393004023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393004024 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 65393004025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393004026 ABC transporter signature motif; other site 65393004027 Walker B; other site 65393004028 D-loop; other site 65393004029 H-loop/switch region; other site 65393004030 PAS fold; Region: PAS_4; pfam08448 65393004031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393004032 putative active site [active] 65393004033 heme pocket [chemical binding]; other site 65393004034 PAS domain S-box; Region: sensory_box; TIGR00229 65393004035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393004036 putative active site [active] 65393004037 heme pocket [chemical binding]; other site 65393004038 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393004039 metal binding site [ion binding]; metal-binding site 65393004040 active site 65393004041 I-site; other site 65393004042 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393004043 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 65393004044 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393004045 FeS/SAM binding site; other site 65393004046 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 65393004047 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 65393004048 substrate binding site [chemical binding]; other site 65393004049 oxyanion hole (OAH) forming residues; other site 65393004050 trimer interface [polypeptide binding]; other site 65393004051 Protein of unknown function (DUF721); Region: DUF721; cl02324 65393004052 PspA/IM30 family; Region: PspA_IM30; pfam04012 65393004053 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 65393004054 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 65393004055 G1 box; other site 65393004056 GTP/Mg2+ binding site [chemical binding]; other site 65393004057 Switch I region; other site 65393004058 G2 box; other site 65393004059 Switch II region; other site 65393004060 G3 box; other site 65393004061 G4 box; other site 65393004062 G5 box; other site 65393004063 Domain of unknown function (DUF697); Region: DUF697; cl12064 65393004064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004065 binding surface 65393004066 TPR motif; other site 65393004067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004068 binding surface 65393004069 TPR motif; other site 65393004070 putative lipid kinase; Reviewed; Region: PRK00861 65393004071 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 65393004072 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 65393004073 dimanganese center [ion binding]; other site 65393004074 phosphodiesterase; Provisional; Region: PRK12704 65393004075 Calicivirus minor structural protein; Region: Calici_MSP; pfam05752 65393004076 GUN4-like; Region: GUN4; pfam05419 65393004077 Phage protein D [General function prediction only]; Region: COG3500; cl12180 65393004078 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 65393004079 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 65393004080 Protein kinase domain; Region: Pkinase; pfam00069 65393004081 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 65393004082 active site 65393004083 ATP binding site [chemical binding]; other site 65393004084 substrate binding site [chemical binding]; other site 65393004085 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393004086 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 65393004087 Surface antigen; Region: Bac_surface_Ag; cl03097 65393004088 haemagglutination activity domain; Region: Haemagg_act; cl05436 65393004089 CHAT domain; Region: CHAT; cl02083 65393004090 Domain of unknown function (DUF389); Region: DUF389; cl00781 65393004091 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 65393004092 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 65393004093 Glutaminase; Region: Glutaminase; cl00907 65393004094 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 65393004095 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393004096 ligand binding site [chemical binding]; other site 65393004097 flexible hinge region; other site 65393004098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393004099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393004100 active site 65393004101 ATP binding site [chemical binding]; other site 65393004102 substrate binding site [chemical binding]; other site 65393004103 activation loop (A-loop); other site 65393004104 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393004105 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393004106 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 65393004107 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 65393004108 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 65393004109 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 65393004110 Peptidase family M23; Region: Peptidase_M23; pfam01551 65393004111 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 65393004112 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 65393004113 N-acetyl-D-glucosamine binding site [chemical binding]; other site 65393004114 catalytic residue [active] 65393004115 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 65393004116 NAD(P) binding site [chemical binding]; other site 65393004117 putative active site [active] 65393004118 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 65393004119 Entner-Doudoroff aldolase; Region: eda; TIGR01182 65393004120 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 65393004121 active site 65393004122 intersubunit interface [polypeptide binding]; other site 65393004123 catalytic residue [active] 65393004124 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 65393004125 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 65393004126 active site 65393004127 metal binding site [ion binding]; metal-binding site 65393004128 CVNH domain; Region: CVNH; pfam08881 65393004129 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393004130 Ligand Binding Site [chemical binding]; other site 65393004131 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 65393004132 active site 65393004133 putative DNA-binding cleft [nucleotide binding]; other site 65393004134 dimer interface [polypeptide binding]; other site 65393004135 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 65393004136 NeuB family; Region: NeuB; cl00496 65393004137 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 65393004138 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 65393004139 16S/18S rRNA binding site [nucleotide binding]; other site 65393004140 S13e-L30e interaction site [polypeptide binding]; other site 65393004141 25S rRNA binding site [nucleotide binding]; other site 65393004142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004143 NAD(P) binding site [chemical binding]; other site 65393004144 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 65393004145 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 65393004146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004147 active site 65393004148 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 65393004149 RNA/DNA binding site [nucleotide binding]; other site 65393004150 RRM dimerization site [polypeptide binding]; other site 65393004151 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 65393004152 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 65393004153 active site 65393004154 dimer interface [polypeptide binding]; other site 65393004155 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393004156 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 65393004157 ATP adenylyltransferase; Region: ATP_transf; pfam09830 65393004158 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 65393004159 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393004160 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 65393004161 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393004162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393004163 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393004164 Probable transposase; Region: OrfB_IS605; pfam01385 65393004165 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393004166 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393004167 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393004168 hypothetical protein; Provisional; Region: PRK07394 65393004169 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 65393004170 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 65393004171 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393004172 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 65393004173 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 65393004174 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 65393004175 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 65393004176 CHAT domain; Region: CHAT; cl02083 65393004177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393004178 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 65393004179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004180 domain; Region: Succ_DH_flav_C; pfam02910 65393004181 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 65393004182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004183 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 65393004184 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 65393004185 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 65393004186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393004187 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393004188 Probable transposase; Region: OrfB_IS605; pfam01385 65393004189 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393004190 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 65393004191 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 65393004192 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 65393004193 iron-sulfur cluster [ion binding]; other site 65393004194 [2Fe-2S] cluster binding site [ion binding]; other site 65393004195 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 65393004196 active site residue [active] 65393004197 Helix-turn-helix domains; Region: HTH; cl00088 65393004198 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 65393004199 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 65393004200 Cysteine-rich domain; Region: CCG; pfam02754 65393004201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004202 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 65393004203 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 65393004204 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 65393004205 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 65393004206 Cysteine-rich domain; Region: CCG; pfam02754 65393004207 Cysteine-rich domain; Region: CCG; pfam02754 65393004208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 65393004209 dimerization interface [polypeptide binding]; other site 65393004210 putative DNA binding site [nucleotide binding]; other site 65393004211 putative Zn2+ binding site [ion binding]; other site 65393004212 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 65393004213 active site residue [active] 65393004214 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393004215 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 65393004216 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 65393004217 active site residue [active] 65393004218 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 65393004219 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 65393004220 pheophytin binding site; other site 65393004221 chlorophyll binding site; other site 65393004222 quinone binding site; other site 65393004223 Fe binding site [ion binding]; other site 65393004224 Predicted transcriptional regulator [Transcription]; Region: COG2378 65393004225 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393004226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393004227 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 65393004228 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 65393004229 CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174 65393004230 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869 65393004231 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cl11870 65393004232 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 65393004233 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 65393004234 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 65393004235 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 65393004236 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 65393004237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393004238 S-adenosylmethionine binding site [chemical binding]; other site 65393004239 Response regulator receiver domain; Region: Response_reg; pfam00072 65393004240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004241 active site 65393004242 phosphorylation site [posttranslational modification] 65393004243 intermolecular recognition site; other site 65393004244 dimerization interface [polypeptide binding]; other site 65393004245 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393004246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004247 active site 65393004248 phosphorylation site [posttranslational modification] 65393004249 intermolecular recognition site; other site 65393004250 dimerization interface [polypeptide binding]; other site 65393004251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393004252 DNA binding site [nucleotide binding] 65393004253 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 65393004254 Response regulator receiver domain; Region: Response_reg; pfam00072 65393004255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004256 active site 65393004257 phosphorylation site [posttranslational modification] 65393004258 intermolecular recognition site; other site 65393004259 dimerization interface [polypeptide binding]; other site 65393004260 Response regulator receiver domain; Region: Response_reg; pfam00072 65393004261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004262 active site 65393004263 phosphorylation site [posttranslational modification] 65393004264 intermolecular recognition site; other site 65393004265 dimerization interface [polypeptide binding]; other site 65393004266 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 65393004267 amphipathic channel; other site 65393004268 Asn-Pro-Ala signature motifs; other site 65393004269 Baseplate J-like protein; Region: Baseplate_J; cl01294 65393004270 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 65393004271 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 65393004272 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 65393004273 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 65393004274 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 65393004275 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 65393004276 Phage protein D [General function prediction only]; Region: COG3500; cl12180 65393004277 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 65393004278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004279 binding surface 65393004280 TPR motif; other site 65393004281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004282 binding surface 65393004283 TPR motif; other site 65393004284 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 65393004285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004286 binding surface 65393004287 TPR motif; other site 65393004288 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 65393004289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004290 binding surface 65393004291 TPR motif; other site 65393004292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393004293 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 65393004294 Walker A motif; other site 65393004295 ATP binding site [chemical binding]; other site 65393004296 Walker B motif; other site 65393004297 arginine finger; other site 65393004298 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 65393004299 active site 65393004300 catalytic site [active] 65393004301 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 65393004302 active site 65393004303 ATP binding site [chemical binding]; other site 65393004304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393004305 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 65393004306 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 65393004307 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 65393004308 Cache domain; Region: Cache_1; pfam02743 65393004309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393004310 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 65393004311 structural tetrad; other site 65393004312 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 65393004313 Predicted membrane protein [Function unknown]; Region: COG1470 65393004314 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393004315 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393004316 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393004317 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393004318 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393004319 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393004320 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393004321 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393004322 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393004323 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 65393004324 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 65393004325 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 65393004326 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 65393004327 haemagglutination activity domain; Region: Haemagg_act; cl05436 65393004328 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 65393004329 CHAT domain; Region: CHAT; cl02083 65393004330 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 65393004331 CHASE2 domain; Region: CHASE2; cl01732 65393004332 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393004333 metal binding site [ion binding]; metal-binding site 65393004334 active site 65393004335 I-site; other site 65393004336 haemagglutination activity domain; Region: Haemagg_act; cl05436 65393004337 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 65393004338 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 65393004339 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393004340 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393004341 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 65393004342 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 65393004343 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 65393004344 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 65393004345 NADP binding site [chemical binding]; other site 65393004346 substrate binding site [chemical binding]; other site 65393004347 active site 65393004348 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 65393004349 excinuclease ABC subunit B; Provisional; Region: PRK05298 65393004350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393004351 ATP binding site [chemical binding]; other site 65393004352 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393004353 nucleotide binding region [chemical binding]; other site 65393004354 ATP-binding site [chemical binding]; other site 65393004355 Ultra-violet resistance protein B; Region: UvrB; pfam12344 65393004356 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 65393004357 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 65393004358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004359 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 65393004360 catalytic loop [active] 65393004361 iron binding site [ion binding]; other site 65393004362 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 65393004363 active site 65393004364 catalytic triad [active] 65393004365 oxyanion hole [active] 65393004366 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 65393004367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004368 SelR domain; Region: SelR; cl00369 65393004369 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 65393004370 elongation factor G; Reviewed; Region: PRK12740 65393004371 G1 box; other site 65393004372 putative GEF interaction site [polypeptide binding]; other site 65393004373 GTP/Mg2+ binding site [chemical binding]; other site 65393004374 Switch I region; other site 65393004375 G2 box; other site 65393004376 G3 box; other site 65393004377 Switch II region; other site 65393004378 G4 box; other site 65393004379 G5 box; other site 65393004380 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 65393004381 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 65393004382 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 65393004383 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393004384 putative active site [active] 65393004385 multifunctional aminopeptidase A; Provisional; Region: PRK00913 65393004386 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 65393004387 interface (dimer of trimers) [polypeptide binding]; other site 65393004388 Substrate-binding/catalytic site; other site 65393004389 Zn-binding sites [ion binding]; other site 65393004390 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 65393004391 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 65393004392 Domain of unknown function DUF143; Region: DUF143; cl00519 65393004393 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 65393004394 L-asparaginase II; Region: Asparaginase_II; cl01842 65393004395 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 65393004396 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 65393004397 ring oligomerisation interface [polypeptide binding]; other site 65393004398 ATP/Mg binding site [chemical binding]; other site 65393004399 stacking interactions; other site 65393004400 hinge regions; other site 65393004401 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 65393004402 oligomerisation interface [polypeptide binding]; other site 65393004403 mobile loop; other site 65393004404 roof hairpin; other site 65393004405 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 65393004406 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393004407 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 65393004408 dimerization interface [polypeptide binding]; other site 65393004409 Photosystem II protein; Region: PSII; cl08223 65393004410 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 65393004411 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 65393004412 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 65393004413 active site 65393004414 metal binding site [ion binding]; metal-binding site 65393004415 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 65393004416 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 65393004417 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 65393004418 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 65393004419 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 65393004420 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 65393004421 hinge; other site 65393004422 active site 65393004423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004424 binding surface 65393004425 TPR motif; other site 65393004426 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 65393004427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004428 binding surface 65393004429 TPR motif; other site 65393004430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004431 binding surface 65393004432 TPR motif; other site 65393004433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004434 binding surface 65393004435 TPR motif; other site 65393004436 CHAT domain; Region: CHAT; cl02083 65393004437 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393004438 GAF domain; Region: GAF; cl00853 65393004439 PAS domain S-box; Region: sensory_box; TIGR00229 65393004440 PAS domain S-box; Region: sensory_box; TIGR00229 65393004441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393004442 PAS domain S-box; Region: sensory_box; TIGR00229 65393004443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393004444 putative active site [active] 65393004445 heme pocket [chemical binding]; other site 65393004446 GAF domain; Region: GAF; cl00853 65393004447 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393004448 metal binding site [ion binding]; metal-binding site 65393004449 active site 65393004450 I-site; other site 65393004451 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393004452 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 65393004453 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 65393004454 dimer interface [polypeptide binding]; other site 65393004455 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 65393004456 active site 65393004457 Fe binding site [ion binding]; other site 65393004458 tocopherol O-methyltransferase; Region: PLN02244 65393004459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393004460 S-adenosylmethionine binding site [chemical binding]; other site 65393004461 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393004462 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; cl00418 65393004463 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 65393004464 NifU-like domain; Region: NifU; cl00484 65393004465 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 65393004466 iron-sulfur cluster [ion binding]; other site 65393004467 [2Fe-2S] cluster binding site [ion binding]; other site 65393004468 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 65393004469 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 65393004470 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 65393004471 nickel binding site [ion binding]; other site 65393004472 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393004473 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 65393004474 TM2 domain; Region: TM2; cl00984 65393004475 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 65393004476 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in...; Region: RNA_Cyclase_Class_II; cd00874 65393004477 putative active site [active] 65393004478 adenylation catalytic residue [active] 65393004479 seryl-tRNA synthetase; Provisional; Region: PRK05431 65393004480 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 65393004481 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 65393004482 dimer interface [polypeptide binding]; other site 65393004483 active site 65393004484 motif 1; other site 65393004485 motif 2; other site 65393004486 motif 3; other site 65393004487 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 65393004488 metal ion-dependent adhesion site (MIDAS); other site 65393004489 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393004490 putative active site [active] 65393004491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393004492 phosphoenolpyruvate synthase; Validated; Region: PRK06464 65393004493 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 65393004494 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 65393004495 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 65393004496 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 65393004497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004498 NAD(P) binding site [chemical binding]; other site 65393004499 active site 65393004500 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 65393004501 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 65393004502 Protein of unknown function, DUF393; Region: DUF393; cl01136 65393004503 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 65393004504 ArsC family; Region: ArsC; pfam03960 65393004505 putative catalytic residues [active] 65393004506 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 65393004507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004508 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 65393004509 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393004510 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 65393004511 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 65393004512 G1 box; other site 65393004513 putative GEF interaction site [polypeptide binding]; other site 65393004514 GTP/Mg2+ binding site [chemical binding]; other site 65393004515 Switch I region; other site 65393004516 G2 box; other site 65393004517 G3 box; other site 65393004518 Switch II region; other site 65393004519 G4 box; other site 65393004520 G5 box; other site 65393004521 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 65393004522 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 65393004523 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 65393004524 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 65393004525 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 65393004526 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 65393004527 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 65393004528 substrate binding pocket [chemical binding]; other site 65393004529 membrane-bound complex binding site; other site 65393004530 hinge residues; other site 65393004531 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 65393004532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393004533 dimer interface [polypeptide binding]; other site 65393004534 conserved gate region; other site 65393004535 putative PBP binding loops; other site 65393004536 ABC-ATPase subunit interface; other site 65393004537 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 65393004538 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 65393004539 Walker A/P-loop; other site 65393004540 ATP binding site [chemical binding]; other site 65393004541 Q-loop/lid; other site 65393004542 ABC transporter signature motif; other site 65393004543 Walker B; other site 65393004544 D-loop; other site 65393004545 H-loop/switch region; other site 65393004546 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 65393004547 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 65393004548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004549 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 65393004550 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 65393004551 NAD binding site [chemical binding]; other site 65393004552 putative substrate binding site 2 [chemical binding]; other site 65393004553 putative substrate binding site 1 [chemical binding]; other site 65393004554 active site 65393004555 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 65393004556 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 65393004557 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 65393004558 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393004559 GAF domain; Region: GAF; cl00853 65393004560 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393004561 GAF domain; Region: GAF; cl00853 65393004562 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393004563 GAF domain; Region: GAF; cl00853 65393004564 GAF domain; Region: GAF; cl00853 65393004565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 65393004566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393004567 dimer interface [polypeptide binding]; other site 65393004568 phosphorylation site [posttranslational modification] 65393004569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393004570 ATP binding site [chemical binding]; other site 65393004571 Mg2+ binding site [ion binding]; other site 65393004572 G-X-G motif; other site 65393004573 Response regulator receiver domain; Region: Response_reg; pfam00072 65393004574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004575 active site 65393004576 phosphorylation site [posttranslational modification] 65393004577 intermolecular recognition site; other site 65393004578 dimerization interface [polypeptide binding]; other site 65393004579 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 65393004580 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393004581 ABC transporter signature motif; other site 65393004582 Walker B; other site 65393004583 D-loop; other site 65393004584 H-loop/switch region; other site 65393004585 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 65393004586 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 65393004587 HIGH motif; other site 65393004588 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 65393004589 active site 65393004590 KMSKS motif; other site 65393004591 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 65393004592 tRNA binding surface [nucleotide binding]; other site 65393004593 Predicted ATPase [General function prediction only]; Region: COG4637 65393004594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393004595 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 65393004596 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 65393004597 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 65393004598 Peptidase family M48; Region: Peptidase_M48; cl12018 65393004599 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 65393004600 Ribosome-binding factor A; Region: RBFA; cl00542 65393004601 Protein of unknown function (DUF751); Region: DUF751; pfam05421 65393004602 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 65393004603 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 65393004604 active site 65393004605 putative substrate binding region [chemical binding]; other site 65393004606 FOG: CBS domain [General function prediction only]; Region: COG0517 65393004607 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 65393004608 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 65393004609 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 65393004610 active site 65393004611 acyl-CoA synthetase; Validated; Region: PRK05850 65393004612 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393004613 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393004614 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 65393004615 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 65393004616 active site 65393004617 Acyl transferase domain; Region: Acyl_transf_1; cl08282 65393004618 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 65393004619 putative NADP binding site [chemical binding]; other site 65393004620 active site 65393004621 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393004622 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393004623 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393004624 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393004625 Clp protease ATP binding subunit; Region: clpC; CHL00095 65393004626 Clp amino terminal domain; Region: Clp_N; pfam02861 65393004627 Clp amino terminal domain; Region: Clp_N; pfam02861 65393004628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393004629 Walker A motif; other site 65393004630 ATP binding site [chemical binding]; other site 65393004631 Walker B motif; other site 65393004632 arginine finger; other site 65393004633 UvrB/uvrC motif; Region: UVR; pfam02151 65393004634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393004635 Walker A motif; other site 65393004636 ATP binding site [chemical binding]; other site 65393004637 Walker B motif; other site 65393004638 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 65393004639 HerA helicase [Replication, recombination, and repair]; Region: COG0433 65393004640 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393004641 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393004642 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393004643 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 65393004644 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 65393004645 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 65393004646 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393004647 Coenzyme A binding pocket [chemical binding]; other site 65393004648 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 65393004649 MoaE interaction surface [polypeptide binding]; other site 65393004650 MoeB interaction surface [polypeptide binding]; other site 65393004651 thiocarboxylated glycine; other site 65393004652 Protein of unknown function (DUF552); Region: DUF552; cl00775 65393004653 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 65393004654 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 65393004655 CHASE2 domain; Region: CHASE2; cl01732 65393004656 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393004657 metal binding site [ion binding]; metal-binding site 65393004658 active site 65393004659 I-site; other site 65393004660 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393004661 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 65393004662 substrate binding pocket [chemical binding]; other site 65393004663 substrate-Mg2+ binding site; other site 65393004664 aspartate-rich region 1; other site 65393004665 aspartate-rich region 2; other site 65393004666 IPP transferase; Region: IPPT; cl00403 65393004667 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 65393004668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393004669 dimer interface [polypeptide binding]; other site 65393004670 conserved gate region; other site 65393004671 putative PBP binding loops; other site 65393004672 ABC-ATPase subunit interface; other site 65393004673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 65393004674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 65393004675 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 65393004676 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393004677 shikimate kinase; Reviewed; Region: aroK; PRK00131 65393004678 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 65393004679 ADP binding site [chemical binding]; other site 65393004680 magnesium binding site [ion binding]; other site 65393004681 putative shikimate binding site; other site 65393004682 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 65393004683 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 65393004684 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 65393004685 trimer interface [polypeptide binding]; other site 65393004686 active site 65393004687 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 65393004688 catalytic site [active] 65393004689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 65393004690 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393004691 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 65393004692 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 65393004693 active site 65393004694 catalytic tetrad [active] 65393004695 CVNH domain; Region: CVNH; pfam08881 65393004696 CVNH domain; Region: CVNH; pfam08881 65393004697 ThiC family; Region: ThiC; cl08031 65393004698 Protein of unknown function DUF124; Region: DUF124; cl00884 65393004699 High-affinity nickel-transport protein; Region: NicO; cl00964 65393004700 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 65393004701 Ligand binding site; other site 65393004702 Putative Catalytic site; other site 65393004703 DXD motif; other site 65393004704 GtrA-like protein; Region: GtrA; cl00971 65393004705 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 65393004706 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 65393004707 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 65393004708 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 65393004709 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 65393004710 Survival protein SurE; Region: SurE; cl00448 65393004711 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393004712 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393004713 Protein of unknown function, DUF479; Region: DUF479; cl01203 65393004714 hydrolase, alpha/beta fold family protein; Region: PLN02824 65393004715 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 65393004716 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 65393004717 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 65393004718 Anti-sigma-K factor rskA; Region: RskA; cl15366 65393004719 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 65393004720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393004721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393004722 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393004723 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393004724 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 65393004725 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 65393004726 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 65393004727 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 65393004728 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393004729 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393004730 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 65393004731 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 65393004732 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 65393004733 putative ADP-binding pocket [chemical binding]; other site 65393004734 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 65393004735 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 65393004736 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 65393004737 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 65393004738 active site 65393004739 substrate binding site [chemical binding]; other site 65393004740 ATP binding site [chemical binding]; other site 65393004741 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393004742 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 65393004743 protein binding site [polypeptide binding]; other site 65393004744 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 65393004745 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393004746 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 65393004747 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 65393004748 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 65393004749 glycogen synthase; Provisional; Region: glgA; PRK00654 65393004750 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 65393004751 ADP-binding pocket [chemical binding]; other site 65393004752 homodimer interface [polypeptide binding]; other site 65393004753 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 65393004754 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 65393004755 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 65393004756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393004757 Walker A motif; other site 65393004758 ATP binding site [chemical binding]; other site 65393004759 Walker B motif; other site 65393004760 arginine finger; other site 65393004761 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393004762 Predicted membrane protein [Function unknown]; Region: COG1470 65393004763 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 65393004764 structural tetrad; other site 65393004765 Response regulator receiver domain; Region: Response_reg; pfam00072 65393004766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004767 active site 65393004768 phosphorylation site [posttranslational modification] 65393004769 intermolecular recognition site; other site 65393004770 dimerization interface [polypeptide binding]; other site 65393004771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004772 Response regulator receiver domain; Region: Response_reg; pfam00072 65393004773 active site 65393004774 phosphorylation site [posttranslational modification] 65393004775 intermolecular recognition site; other site 65393004776 dimerization interface [polypeptide binding]; other site 65393004777 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 65393004778 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 65393004779 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 65393004780 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 65393004781 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 65393004782 putative binding surface; other site 65393004783 active site 65393004784 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 65393004785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393004786 ATP binding site [chemical binding]; other site 65393004787 Mg2+ binding site [ion binding]; other site 65393004788 G-X-G motif; other site 65393004789 Response regulator receiver domain; Region: Response_reg; pfam00072 65393004790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004791 active site 65393004792 phosphorylation site [posttranslational modification] 65393004793 intermolecular recognition site; other site 65393004794 dimerization interface [polypeptide binding]; other site 65393004795 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 65393004796 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 65393004797 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 65393004798 dimerization interface [polypeptide binding]; other site 65393004799 active site 65393004800 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 65393004801 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 65393004802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 65393004803 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 65393004804 catalytic core [active] 65393004805 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 65393004806 catalytic core [active] 65393004807 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 65393004808 Phycobilisome protein; Region: Phycobilisome; cl08227 65393004809 Domain of unknown function (DUF1821); Region: DUF1821; pfam08851 65393004810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393004811 Helix-turn-helix domains; Region: HTH; cl00088 65393004812 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 65393004813 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 65393004814 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 65393004815 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 65393004816 Uncharacterized conserved protein [Function unknown]; Region: COG3391 65393004817 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 65393004818 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 65393004819 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 65393004820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393004821 dimerization interface [polypeptide binding]; other site 65393004822 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 65393004823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393004824 dimer interface [polypeptide binding]; other site 65393004825 phosphorylation site [posttranslational modification] 65393004826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393004827 ATP binding site [chemical binding]; other site 65393004828 Mg2+ binding site [ion binding]; other site 65393004829 G-X-G motif; other site 65393004830 PAS fold; Region: PAS_4; pfam08448 65393004831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393004832 dimer interface [polypeptide binding]; other site 65393004833 phosphorylation site [posttranslational modification] 65393004834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393004835 ATP binding site [chemical binding]; other site 65393004836 Mg2+ binding site [ion binding]; other site 65393004837 G-X-G motif; other site 65393004838 Response regulator receiver domain; Region: Response_reg; pfam00072 65393004839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004840 active site 65393004841 phosphorylation site [posttranslational modification] 65393004842 intermolecular recognition site; other site 65393004843 dimerization interface [polypeptide binding]; other site 65393004844 PAS fold; Region: PAS_4; pfam08448 65393004845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393004846 putative active site [active] 65393004847 heme pocket [chemical binding]; other site 65393004848 PAS fold; Region: PAS_4; pfam08448 65393004849 PAS domain S-box; Region: sensory_box; TIGR00229 65393004850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393004851 putative active site [active] 65393004852 heme pocket [chemical binding]; other site 65393004853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393004854 dimer interface [polypeptide binding]; other site 65393004855 phosphorylation site [posttranslational modification] 65393004856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393004857 ATP binding site [chemical binding]; other site 65393004858 Mg2+ binding site [ion binding]; other site 65393004859 G-X-G motif; other site 65393004860 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 65393004861 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 65393004862 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 65393004863 NodB motif; other site 65393004864 active site 65393004865 catalytic site [active] 65393004866 metal binding site [ion binding]; metal-binding site 65393004867 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 65393004868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393004869 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393004870 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393004871 DNA binding residues [nucleotide binding] 65393004872 light-harvesting-like protein 3; Provisional; Region: PLN00014 65393004873 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 65393004874 putative metal binding site; other site 65393004875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004876 binding surface 65393004877 TPR motif; other site 65393004878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393004879 dimerization interface [polypeptide binding]; other site 65393004880 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 65393004881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393004882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393004883 dimer interface [polypeptide binding]; other site 65393004884 phosphorylation site [posttranslational modification] 65393004885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393004886 ATP binding site [chemical binding]; other site 65393004887 Mg2+ binding site [ion binding]; other site 65393004888 G-X-G motif; other site 65393004889 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 65393004890 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 65393004891 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393004892 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 65393004893 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 65393004894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004895 NAD(P) binding site [chemical binding]; other site 65393004896 active site 65393004897 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 65393004898 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 65393004899 GTP binding site; other site 65393004900 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 65393004901 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 65393004902 HSP70 interaction site [polypeptide binding]; other site 65393004903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004904 binding surface 65393004905 TPR motif; other site 65393004906 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 65393004907 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 65393004908 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 65393004909 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 65393004910 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 65393004911 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 65393004912 active site 65393004913 (T/H)XGH motif; other site 65393004914 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393004915 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393004916 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 65393004917 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 65393004918 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 65393004919 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 65393004920 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 65393004921 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 65393004922 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393004923 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 65393004924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004925 binding surface 65393004926 TPR motif; other site 65393004927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004928 binding surface 65393004929 TPR motif; other site 65393004930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393004931 binding surface 65393004932 TPR motif; other site 65393004933 Ion channel; Region: Ion_trans_2; cl11596 65393004934 Ion channel; Region: Ion_trans_2; cl11596 65393004935 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 65393004936 serpin-like protein; Provisional; Region: PHA02660 65393004937 reactive center loop; other site 65393004938 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 65393004939 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 65393004940 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 65393004941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393004942 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 65393004943 Ycf39; Provisional; Region: ycf39; CHL00194 65393004944 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 65393004945 NAD(P) binding site [chemical binding]; other site 65393004946 putative active site [active] 65393004947 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 65393004948 putative binding surface; other site 65393004949 active site 65393004950 arogenate dehydrogenase; Reviewed; Region: PRK07417 65393004951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393004952 Ion transport protein; Region: Ion_trans; pfam00520 65393004953 Ion channel; Region: Ion_trans_2; cl11596 65393004954 Response regulator receiver domain; Region: Response_reg; pfam00072 65393004955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004956 active site 65393004957 phosphorylation site [posttranslational modification] 65393004958 intermolecular recognition site; other site 65393004959 dimerization interface [polypeptide binding]; other site 65393004960 PAS domain S-box; Region: sensory_box; TIGR00229 65393004961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393004962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393004963 PAS fold; Region: PAS_3; pfam08447 65393004964 putative active site [active] 65393004965 heme pocket [chemical binding]; other site 65393004966 hypothetical protein; Provisional; Region: PRK13560 65393004967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393004968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393004969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393004970 putative active site [active] 65393004971 heme pocket [chemical binding]; other site 65393004972 PAS domain S-box; Region: sensory_box; TIGR00229 65393004973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393004974 putative active site [active] 65393004975 heme pocket [chemical binding]; other site 65393004976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393004977 PAS fold; Region: PAS_4; pfam08448 65393004978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393004979 dimer interface [polypeptide binding]; other site 65393004980 phosphorylation site [posttranslational modification] 65393004981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393004982 ATP binding site [chemical binding]; other site 65393004983 Mg2+ binding site [ion binding]; other site 65393004984 G-X-G motif; other site 65393004985 Response regulator receiver domain; Region: Response_reg; pfam00072 65393004986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393004987 active site 65393004988 phosphorylation site [posttranslational modification] 65393004989 intermolecular recognition site; other site 65393004990 dimerization interface [polypeptide binding]; other site 65393004991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393004992 metal binding site [ion binding]; metal-binding site 65393004993 active site 65393004994 I-site; other site 65393004995 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393004996 NifU-like domain; Region: NifU; cl00484 65393004997 H+ Antiporter protein; Region: 2A0121; TIGR00900 65393004998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393004999 putative substrate translocation pore; other site 65393005000 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 65393005001 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 65393005002 Predicted ATPase [General function prediction only]; Region: COG4637 65393005003 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005005 Q-loop/lid; other site 65393005006 ABC transporter signature motif; other site 65393005007 Walker B; other site 65393005008 D-loop; other site 65393005009 H-loop/switch region; other site 65393005010 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 65393005011 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393005012 putative active site [active] 65393005013 Adenosine specific kinase; Region: Adenosine_kin; cl00796 65393005014 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 65393005015 Predicted ATPase [General function prediction only]; Region: COG4637 65393005016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005017 CTP synthetase; Validated; Region: pyrG; PRK05380 65393005018 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 65393005019 Catalytic site [active] 65393005020 active site 65393005021 UTP binding site [chemical binding]; other site 65393005022 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 65393005023 active site 65393005024 putative oxyanion hole; other site 65393005025 catalytic triad [active] 65393005026 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 65393005027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393005028 Coenzyme A binding pocket [chemical binding]; other site 65393005029 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393005030 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 65393005031 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 65393005032 aromatic acid decarboxylase; Validated; Region: PRK05920 65393005033 Flavoprotein; Region: Flavoprotein; cl08021 65393005034 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 65393005035 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 65393005036 SmpB-tmRNA interface; other site 65393005037 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 65393005038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393005039 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 65393005040 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393005041 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 65393005042 ketol-acid reductoisomerase; Provisional; Region: PRK05479 65393005043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393005044 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 65393005045 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 65393005046 C-terminal peptidase (prc); Region: prc; TIGR00225 65393005047 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 65393005048 protein binding site [polypeptide binding]; other site 65393005049 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 65393005050 Catalytic dyad [active] 65393005051 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 65393005052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393005053 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393005054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 65393005055 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 65393005056 light-harvesting-like protein 3; Provisional; Region: PLN00014 65393005057 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 65393005058 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 65393005059 DNA binding residues [nucleotide binding] 65393005060 dimer interface [polypeptide binding]; other site 65393005061 metal binding site [ion binding]; metal-binding site 65393005062 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 65393005063 FOG: CBS domain [General function prediction only]; Region: COG0517 65393005064 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 65393005065 CP12 domain; Region: CP12; cl14670 65393005066 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 65393005067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393005068 metal binding site [ion binding]; metal-binding site 65393005069 active site 65393005070 I-site; other site 65393005071 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 65393005072 Probable transposase; Region: OrfB_IS605; pfam01385 65393005073 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393005074 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393005075 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 65393005076 active site 65393005077 catalytic residues [active] 65393005078 metal binding site [ion binding]; metal-binding site 65393005079 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 65393005080 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 65393005081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393005082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393005083 binding surface 65393005084 TPR motif; other site 65393005085 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 65393005086 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393005087 dimerization interface [polypeptide binding]; other site 65393005088 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 65393005089 Sodium:solute symporter family; Region: SSF; cl00456 65393005090 hypothetical protein; Reviewed; Region: PRK00024 65393005091 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 65393005092 MPN+ (JAMM) motif; other site 65393005093 Zinc-binding site [ion binding]; other site 65393005094 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393005095 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 65393005096 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 65393005097 anti sigma factor interaction site; other site 65393005098 regulatory phosphorylation site [posttranslational modification]; other site 65393005099 Bacterial sugar transferase; Region: Bac_transf; cl00939 65393005100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 65393005101 Integrase core domain; Region: rve; cl01316 65393005102 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 65393005103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393005104 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 65393005105 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 65393005106 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 65393005107 HsdM N-terminal domain; Region: HsdM_N; pfam12161 65393005108 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 65393005109 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 65393005110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005111 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 65393005112 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 65393005113 putative peptidoglycan binding site; other site 65393005114 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 65393005115 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 65393005116 putative peptidoglycan binding site; other site 65393005117 Peptidase family M23; Region: Peptidase_M23; pfam01551 65393005118 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 65393005119 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 65393005120 amidohydrolase; Region: amidohydrolases; TIGR01891 65393005121 metal binding site [ion binding]; metal-binding site 65393005122 dimer interface [polypeptide binding]; other site 65393005123 DevC protein; Region: devC; TIGR01185 65393005124 FtsX-like permease family; Region: FtsX; pfam02687 65393005125 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 65393005126 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 65393005127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393005128 Helix-turn-helix domains; Region: HTH; cl00088 65393005129 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 65393005130 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 65393005131 active site 65393005132 catalytic tetrad [active] 65393005133 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 65393005134 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 65393005135 NADPH bind site [chemical binding]; other site 65393005136 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 65393005137 putative FMN binding site [chemical binding]; other site 65393005138 NADPH bind site [chemical binding]; other site 65393005139 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 65393005140 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 65393005141 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 65393005142 4Fe-4S binding domain; Region: Fer4; cl02805 65393005143 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 65393005144 catalytic loop [active] 65393005145 iron binding site [ion binding]; other site 65393005146 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 65393005147 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 65393005148 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 65393005149 ATP binding site [chemical binding]; other site 65393005150 substrate interface [chemical binding]; other site 65393005151 Nitrogen fixation protein NifW; Region: NifW; cl03935 65393005152 Protein of unknown function (DUF683); Region: DUF683; cl02247 65393005153 Protein of unknown function, DUF269; Region: DUF269; cl03973 65393005154 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 65393005155 Protein of unknown function, DUF269; Region: DUF269; cl03973 65393005156 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 65393005157 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 65393005158 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 65393005159 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 65393005160 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 65393005161 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 65393005162 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 65393005163 MoFe protein beta/alpha subunit interactions; other site 65393005164 Beta subunit P cluster binding residues; other site 65393005165 MoFe protein beta subunit/Fe protein contacts; other site 65393005166 MoFe protein dimer/ dimer interactions; other site 65393005167 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 65393005168 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 65393005169 MoFe protein alpha/beta subunit interactions; other site 65393005170 Alpha subunit P cluster binding residues; other site 65393005171 FeMoco binding residues [chemical binding]; other site 65393005172 MoFe protein alpha subunit/Fe protein contacts; other site 65393005173 MoFe protein dimer/ dimer interactions; other site 65393005174 nitrogenase reductase; Reviewed; Region: PRK13236 65393005175 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 65393005176 Nucleotide-binding sites [chemical binding]; other site 65393005177 Walker A motif; other site 65393005178 Switch I region of nucleotide binding site; other site 65393005179 Fe4S4 binding sites [ion binding]; other site 65393005180 Switch II region of nucleotide binding site; other site 65393005181 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 65393005182 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 65393005183 trimerization site [polypeptide binding]; other site 65393005184 active site 65393005185 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 65393005186 NifU-like domain; Region: NifU; cl00484 65393005187 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 65393005188 Aminotransferase class-V; Region: Aminotran_5; pfam00266 65393005189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393005190 catalytic residue [active] 65393005191 ferredoxin; Validated; Region: PRK07118 65393005192 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 65393005193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393005194 FeS/SAM binding site; other site 65393005195 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 65393005196 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 65393005197 serine O-acetyltransferase; Region: cysE; TIGR01172 65393005198 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 65393005199 trimer interface [polypeptide binding]; other site 65393005200 active site 65393005201 substrate binding site [chemical binding]; other site 65393005202 CoA binding site [chemical binding]; other site 65393005203 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 65393005204 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 65393005205 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 65393005206 active site 65393005207 catalytic residues [active] 65393005208 metal binding site [ion binding]; metal-binding site 65393005209 NifZ domain; Region: NifZ; pfam04319 65393005210 NifT/FixU protein; Region: NifT; cl02351 65393005211 FOG: CBS domain [General function prediction only]; Region: COG0517 65393005212 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 65393005213 CP12 domain; Region: CP12; cl14670 65393005214 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 65393005215 4Fe-4S binding domain; Region: Fer4; cl02805 65393005216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 65393005217 non-specific DNA binding site [nucleotide binding]; other site 65393005218 salt bridge; other site 65393005219 sequence-specific DNA binding site [nucleotide binding]; other site 65393005220 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 65393005221 EamA-like transporter family; Region: EamA; cl01037 65393005222 EamA-like transporter family; Region: EamA; cl01037 65393005223 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 65393005224 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 65393005225 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 65393005226 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 65393005227 active site 65393005228 phosphate binding residues; other site 65393005229 catalytic residues [active] 65393005230 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 65393005231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393005232 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393005233 Probable transposase; Region: OrfB_IS605; pfam01385 65393005234 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393005235 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 65393005236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 65393005237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393005238 homodimer interface [polypeptide binding]; other site 65393005239 catalytic residue [active] 65393005240 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 65393005241 catalytic residues [active] 65393005242 PspA/IM30 family; Region: PspA_IM30; pfam04012 65393005243 DevC protein; Region: devC; TIGR01185 65393005244 FtsX-like permease family; Region: FtsX; pfam02687 65393005245 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 65393005246 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 65393005247 Walker A/P-loop; other site 65393005248 ATP binding site [chemical binding]; other site 65393005249 Q-loop/lid; other site 65393005250 ABC transporter signature motif; other site 65393005251 Walker B; other site 65393005252 D-loop; other site 65393005253 H-loop/switch region; other site 65393005254 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 65393005255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393005256 S-adenosylmethionine binding site [chemical binding]; other site 65393005257 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 65393005258 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 65393005259 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 65393005260 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 65393005261 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 65393005262 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 65393005263 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 65393005264 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 65393005265 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 65393005266 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 65393005267 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 65393005268 amidase; Provisional; Region: PRK09201 65393005269 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 65393005270 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 65393005271 Hexamer interface [polypeptide binding]; other site 65393005272 Hexagonal pore residue; other site 65393005273 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 65393005274 Hexamer interface [polypeptide binding]; other site 65393005275 Hexagonal pore residue; other site 65393005276 gamma-glutamyl kinase; Provisional; Region: PRK05429 65393005277 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 65393005278 nucleotide binding site [chemical binding]; other site 65393005279 homotetrameric interface [polypeptide binding]; other site 65393005280 putative phosphate binding site [ion binding]; other site 65393005281 putative allosteric binding site; other site 65393005282 PUA domain; Region: PUA; cl00607 65393005283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393005284 active site 65393005285 motif I; other site 65393005286 motif II; other site 65393005287 ferrochelatase; Reviewed; Region: hemH; PRK00035 65393005288 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 65393005289 active site 65393005290 C-terminal domain interface [polypeptide binding]; other site 65393005291 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 65393005292 active site 65393005293 N-terminal domain interface [polypeptide binding]; other site 65393005294 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 65393005295 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393005296 putative active site [active] 65393005297 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 65393005298 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393005299 putative active site [active] 65393005300 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 65393005301 active site 65393005302 catalytic triad [active] 65393005303 oxyanion hole [active] 65393005304 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 65393005305 malate dehydrogenase; Reviewed; Region: PRK06223 65393005306 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 65393005307 NAD(P) binding site [chemical binding]; other site 65393005308 dimer interface [polypeptide binding]; other site 65393005309 tetramer (dimer of dimers) interface [polypeptide binding]; other site 65393005310 substrate binding site [chemical binding]; other site 65393005311 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 65393005312 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393005313 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 65393005314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393005315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393005316 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 65393005317 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 65393005318 putative active site [active] 65393005319 putative metal binding site [ion binding]; other site 65393005320 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 65393005321 MPN+ (JAMM) motif; other site 65393005322 Zinc-binding site [ion binding]; other site 65393005323 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 65393005324 cobalt transport protein CbiN; Validated; Region: PRK06287 65393005325 Cobalt transport protein; Region: CbiQ; cl00463 65393005326 Domain of unknown function DUF; Region: DUF204; pfam02659 65393005327 Domain of unknown function DUF; Region: DUF204; pfam02659 65393005328 Response regulator receiver domain; Region: Response_reg; pfam00072 65393005329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393005330 active site 65393005331 phosphorylation site [posttranslational modification] 65393005332 intermolecular recognition site; other site 65393005333 dimerization interface [polypeptide binding]; other site 65393005334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 65393005335 dimer interface [polypeptide binding]; other site 65393005336 phosphorylation site [posttranslational modification] 65393005337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393005338 ATP binding site [chemical binding]; other site 65393005339 Mg2+ binding site [ion binding]; other site 65393005340 G-X-G motif; other site 65393005341 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 65393005342 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 65393005343 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 65393005344 hydrophobic ligand binding site; other site 65393005345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393005346 Radical SAM superfamily; Region: Radical_SAM; pfam04055 65393005347 FeS/SAM binding site; other site 65393005348 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 65393005349 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393005350 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 65393005351 active site 65393005352 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 65393005353 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393005354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393005355 Probable transposase; Region: OrfB_IS605; pfam01385 65393005356 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393005357 Phycobilisome protein; Region: Phycobilisome; cl08227 65393005358 glutamine synthetase, type I; Region: GlnA; TIGR00653 65393005359 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 65393005360 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 65393005361 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 65393005362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393005363 S-adenosylmethionine binding site [chemical binding]; other site 65393005364 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 65393005365 Protein of unknown function (DUF433); Region: DUF433; cl01030 65393005366 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393005367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393005368 Probable transposase; Region: OrfB_IS605; pfam01385 65393005369 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393005370 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 65393005371 Sulfatase; Region: Sulfatase; cl10460 65393005372 Preprotein translocase SecG subunit; Region: SecG; cl09123 65393005373 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 65393005374 active site 65393005375 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 65393005376 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 65393005377 NAD binding site [chemical binding]; other site 65393005378 catalytic residues [active] 65393005379 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393005380 Domain of unknown function DUF11; Region: DUF11; cl15273 65393005381 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 65393005382 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 65393005383 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 65393005384 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 65393005385 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 65393005386 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 65393005387 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 65393005388 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 65393005389 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 65393005390 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 65393005391 FAD binding domain; Region: FAD_binding_4; pfam01565 65393005392 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 65393005393 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 65393005394 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393005395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393005396 Probable transposase; Region: OrfB_IS605; pfam01385 65393005397 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393005398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393005399 S-adenosylmethionine binding site [chemical binding]; other site 65393005400 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 65393005401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393005402 FeS/SAM binding site; other site 65393005403 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 65393005404 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 65393005405 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 65393005406 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 65393005407 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 65393005408 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 65393005409 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 65393005410 dimer interface [polypeptide binding]; other site 65393005411 putative functional site; other site 65393005412 putative MPT binding site; other site 65393005413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 65393005414 active site 65393005415 phosphorylation site [posttranslational modification] 65393005416 intermolecular recognition site; other site 65393005417 dimerization interface [polypeptide binding]; other site 65393005418 PAS fold; Region: PAS_4; pfam08448 65393005419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393005420 putative active site [active] 65393005421 heme pocket [chemical binding]; other site 65393005422 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 65393005423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393005424 putative active site [active] 65393005425 heme pocket [chemical binding]; other site 65393005426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393005427 dimer interface [polypeptide binding]; other site 65393005428 phosphorylation site [posttranslational modification] 65393005429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393005430 ATP binding site [chemical binding]; other site 65393005431 Mg2+ binding site [ion binding]; other site 65393005432 G-X-G motif; other site 65393005433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393005434 Response regulator receiver domain; Region: Response_reg; pfam00072 65393005435 active site 65393005436 phosphorylation site [posttranslational modification] 65393005437 intermolecular recognition site; other site 65393005438 dimerization interface [polypeptide binding]; other site 65393005439 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 65393005440 HSP70 interaction site [polypeptide binding]; other site 65393005441 NC domain; Region: NC; pfam04970 65393005442 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 65393005443 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 65393005444 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 65393005445 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 65393005446 Predicted transcriptional regulators [Transcription]; Region: COG1725 65393005447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 65393005448 DNA-binding site [nucleotide binding]; DNA binding site 65393005449 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 65393005450 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393005451 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 65393005452 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 65393005453 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 65393005454 active site 65393005455 catalytic residues [active] 65393005456 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393005457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393005458 active site 65393005459 phosphorylation site [posttranslational modification] 65393005460 intermolecular recognition site; other site 65393005461 dimerization interface [polypeptide binding]; other site 65393005462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393005463 DNA binding site [nucleotide binding] 65393005464 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 65393005465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393005466 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 65393005467 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 65393005468 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 65393005469 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 65393005470 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 65393005471 metal binding site 2 [ion binding]; metal-binding site 65393005472 putative DNA binding helix; other site 65393005473 metal binding site 1 [ion binding]; metal-binding site 65393005474 dimer interface [polypeptide binding]; other site 65393005475 structural Zn2+ binding site [ion binding]; other site 65393005476 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 65393005477 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 65393005478 putative active site [active] 65393005479 catalytic triad [active] 65393005480 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 65393005481 Qi binding site; other site 65393005482 intrachain domain interface; other site 65393005483 interchain domain interface [polypeptide binding]; other site 65393005484 heme bH binding site [chemical binding]; other site 65393005485 heme bL binding site [chemical binding]; other site 65393005486 Qo binding site; other site 65393005487 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 65393005488 interchain domain interface [polypeptide binding]; other site 65393005489 intrachain domain interface; other site 65393005490 Qi binding site; other site 65393005491 Qo binding site; other site 65393005492 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 65393005493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393005494 GAF domain; Region: GAF; cl00853 65393005495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393005496 dimer interface [polypeptide binding]; other site 65393005497 phosphorylation site [posttranslational modification] 65393005498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393005499 ATP binding site [chemical binding]; other site 65393005500 Mg2+ binding site [ion binding]; other site 65393005501 G-X-G motif; other site 65393005502 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 65393005503 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 65393005504 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 65393005505 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 65393005506 cofactor binding site; other site 65393005507 DNA binding site [nucleotide binding] 65393005508 substrate interaction site [chemical binding]; other site 65393005509 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 65393005510 dimer interface [polypeptide binding]; other site 65393005511 catalytic triad [active] 65393005512 multicopper oxidase; Provisional; Region: PRK10965 65393005513 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393005514 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393005515 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 65393005516 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 65393005517 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393005518 catalytic residue [active] 65393005519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393005520 binding surface 65393005521 TPR motif; other site 65393005522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393005523 binding surface 65393005524 TPR motif; other site 65393005525 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 65393005526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393005527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393005528 Response regulator receiver domain; Region: Response_reg; pfam00072 65393005529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393005530 active site 65393005531 phosphorylation site [posttranslational modification] 65393005532 intermolecular recognition site; other site 65393005533 dimerization interface [polypeptide binding]; other site 65393005534 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393005535 metal binding site [ion binding]; metal-binding site 65393005536 active site 65393005537 I-site; other site 65393005538 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 65393005539 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 65393005540 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005541 Walker A motif; other site 65393005542 ATP binding site [chemical binding]; other site 65393005543 Walker B motif; other site 65393005544 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 65393005545 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 65393005546 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 65393005547 active site 65393005548 catalytic site [active] 65393005549 hypothetical protein; Provisional; Region: PRK13560 65393005550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393005551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393005552 dimer interface [polypeptide binding]; other site 65393005553 phosphorylation site [posttranslational modification] 65393005554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393005555 ATP binding site [chemical binding]; other site 65393005556 Mg2+ binding site [ion binding]; other site 65393005557 G-X-G motif; other site 65393005558 Response regulator receiver domain; Region: Response_reg; pfam00072 65393005559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393005560 active site 65393005561 phosphorylation site [posttranslational modification] 65393005562 intermolecular recognition site; other site 65393005563 dimerization interface [polypeptide binding]; other site 65393005564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 65393005565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 65393005566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 65393005567 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 65393005568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393005569 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 65393005570 NeuB family; Region: NeuB; cl00496 65393005571 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 65393005572 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 65393005573 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 65393005574 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 65393005575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393005576 catalytic residue [active] 65393005577 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 65393005578 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 65393005579 substrate binding site [chemical binding]; other site 65393005580 active site 65393005581 catalytic residues [active] 65393005582 heterodimer interface [polypeptide binding]; other site 65393005583 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 65393005584 active site 65393005585 ribulose/triose binding site [chemical binding]; other site 65393005586 phosphate binding site [ion binding]; other site 65393005587 substrate (anthranilate) binding pocket [chemical binding]; other site 65393005588 product (indole) binding pocket [chemical binding]; other site 65393005589 anthranilate synthase; Provisional; Region: PRK13566 65393005590 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 65393005591 chorismate binding enzyme; Region: Chorismate_bind; cl10555 65393005592 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 65393005593 glutamine binding [chemical binding]; other site 65393005594 catalytic triad [active] 65393005595 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 65393005596 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 65393005597 PYR/PP interface [polypeptide binding]; other site 65393005598 dimer interface [polypeptide binding]; other site 65393005599 TPP binding site [chemical binding]; other site 65393005600 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 65393005601 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 65393005602 TPP-binding site [chemical binding]; other site 65393005603 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 65393005604 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 65393005605 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 65393005606 NAD binding site [chemical binding]; other site 65393005607 Phe binding site; other site 65393005608 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 65393005609 Uncharacterized conserved protein [Function unknown]; Region: COG3391 65393005610 PEP-CTERM motif; Region: VPEP; cl15443 65393005611 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 65393005612 active site 65393005613 UbiA prenyltransferase family; Region: UbiA; cl00337 65393005614 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 65393005615 active site 65393005616 metal binding site [ion binding]; metal-binding site 65393005617 Sulfatase; Region: Sulfatase; cl10460 65393005618 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 65393005619 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 65393005620 putative catalytic site [active] 65393005621 putative metal binding site [ion binding]; other site 65393005622 putative phosphate binding site [ion binding]; other site 65393005623 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 65393005624 protein I interface; other site 65393005625 D2 interface; other site 65393005626 protein T interface; other site 65393005627 chlorophyll binding site; other site 65393005628 beta carotene binding site; other site 65393005629 pheophytin binding site; other site 65393005630 manganese-stabilizing polypeptide interface; other site 65393005631 CP43 interface; other site 65393005632 protein L interface; other site 65393005633 oxygen evolving complex binding site; other site 65393005634 bromide binding site; other site 65393005635 quinone binding site; other site 65393005636 Fe binding site [ion binding]; other site 65393005637 core light harvesting interface; other site 65393005638 cytochrome b559 alpha subunit interface; other site 65393005639 cytochrome c-550 interface; other site 65393005640 protein J interface; other site 65393005641 DNA topoisomerase 2; Provisional; Region: PLN03128 65393005642 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 65393005643 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 65393005644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393005645 catalytic residue [active] 65393005646 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 65393005647 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 65393005648 Protein of unknown function (DUF2393); Region: DUF2393; cl09840 65393005649 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 65393005650 oligomer interface [polypeptide binding]; other site 65393005651 active site residues [active] 65393005652 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 65393005653 oligomer interface [polypeptide binding]; other site 65393005654 active site residues [active] 65393005655 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393005656 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393005657 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393005658 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 65393005659 active site 65393005660 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 65393005661 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393005662 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09688 65393005663 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 65393005664 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892 65393005665 CRISPR/Cas system-associated protein Cas8c'; Region: Cas8c'_I-D; cl11893 65393005666 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 65393005667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393005668 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 65393005669 Walker A motif; other site 65393005670 ATP binding site [chemical binding]; other site 65393005671 Walker B motif; other site 65393005672 arginine finger; other site 65393005673 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393005674 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 65393005675 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005676 Integrase core domain; Region: rve; cl01316 65393005677 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 65393005678 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 65393005679 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 65393005680 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 65393005681 glutaminase active site [active] 65393005682 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 65393005683 dimer interface [polypeptide binding]; other site 65393005684 active site 65393005685 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 65393005686 dimer interface [polypeptide binding]; other site 65393005687 active site 65393005688 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 65393005689 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393005690 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393005691 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393005692 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393005693 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393005694 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393005695 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 65393005696 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 65393005697 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 65393005698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393005699 TPR motif; other site 65393005700 binding surface 65393005701 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 65393005702 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 65393005703 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 65393005704 active site 65393005705 metal binding site [ion binding]; metal-binding site 65393005706 Protein of unknown function (DUF2396); Region: DUF2396; cl09868 65393005707 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 65393005708 trimer interface [polypeptide binding]; other site 65393005709 putative metal binding site [ion binding]; other site 65393005710 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 65393005711 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393005712 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 65393005713 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 65393005714 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 65393005715 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 65393005716 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 65393005717 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 65393005718 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 65393005719 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 65393005720 C-terminal domain interface [polypeptide binding]; other site 65393005721 GSH binding site (G-site) [chemical binding]; other site 65393005722 dimer interface [polypeptide binding]; other site 65393005723 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 65393005724 N-terminal domain interface [polypeptide binding]; other site 65393005725 dimer interface [polypeptide binding]; other site 65393005726 substrate binding pocket (H-site) [chemical binding]; other site 65393005727 CrcB-like protein; Region: CRCB; cl09114 65393005728 Response regulator receiver domain; Region: Response_reg; pfam00072 65393005729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393005730 active site 65393005731 phosphorylation site [posttranslational modification] 65393005732 intermolecular recognition site; other site 65393005733 dimerization interface [polypeptide binding]; other site 65393005734 PAS domain S-box; Region: sensory_box; TIGR00229 65393005735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393005736 putative active site [active] 65393005737 heme pocket [chemical binding]; other site 65393005738 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393005739 GAF domain; Region: GAF; cl00853 65393005740 Response regulator receiver domain; Region: Response_reg; pfam00072 65393005741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393005742 active site 65393005743 phosphorylation site [posttranslational modification] 65393005744 intermolecular recognition site; other site 65393005745 dimerization interface [polypeptide binding]; other site 65393005746 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 65393005747 GAF domain; Region: GAF; cl00853 65393005748 Phytochrome region; Region: PHY; pfam00360 65393005749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393005750 dimer interface [polypeptide binding]; other site 65393005751 phosphorylation site [posttranslational modification] 65393005752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393005753 ATP binding site [chemical binding]; other site 65393005754 Mg2+ binding site [ion binding]; other site 65393005755 G-X-G motif; other site 65393005756 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 65393005757 catalytic core [active] 65393005758 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 65393005759 pyruvate kinase; Region: pyruv_kin; TIGR01064 65393005760 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 65393005761 domain interfaces; other site 65393005762 active site 65393005763 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 65393005764 Tetramer interface [polypeptide binding]; other site 65393005765 active site 65393005766 FMN-binding site [chemical binding]; other site 65393005767 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 65393005768 translation initiation factor IF-2; Region: IF-2; TIGR00487 65393005769 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 65393005770 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 65393005771 G1 box; other site 65393005772 putative GEF interaction site [polypeptide binding]; other site 65393005773 GTP/Mg2+ binding site [chemical binding]; other site 65393005774 Switch I region; other site 65393005775 G2 box; other site 65393005776 G3 box; other site 65393005777 Switch II region; other site 65393005778 G4 box; other site 65393005779 G5 box; other site 65393005780 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 65393005781 Translation-initiation factor 2; Region: IF-2; pfam11987 65393005782 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 65393005783 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 65393005784 putative RNA binding cleft [nucleotide binding]; other site 65393005785 NusA N-terminal domain; Region: NusA_N; pfam08529 65393005786 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 65393005787 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 65393005788 RNA binding site [nucleotide binding]; other site 65393005789 homodimer interface [polypeptide binding]; other site 65393005790 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 65393005791 G-X-X-G motif; other site 65393005792 ribosome maturation protein RimP; Reviewed; Region: PRK00092 65393005793 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 65393005794 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 65393005795 Sm1 motif; other site 65393005796 D3 - B interaction site; other site 65393005797 D1 - D2 interaction site; other site 65393005798 Hfq - Hfq interaction site; other site 65393005799 RNA binding pocket [nucleotide binding]; other site 65393005800 Sm2 motif; other site 65393005801 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 65393005802 quinone interaction residues [chemical binding]; other site 65393005803 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 65393005804 active site 65393005805 catalytic residues [active] 65393005806 FMN binding site [chemical binding]; other site 65393005807 substrate binding site [chemical binding]; other site 65393005808 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 65393005809 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 65393005810 putative di-iron ligands [ion binding]; other site 65393005811 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 65393005812 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393005813 putative active site [active] 65393005814 Uncharacterized conserved protein [Function unknown]; Region: COG4938 65393005815 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005816 Walker B; other site 65393005817 D-loop; other site 65393005818 H-loop/switch region; other site 65393005819 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 65393005820 Protein of unknown function DUF262; Region: DUF262; cl14890 65393005821 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 65393005822 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 65393005823 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 65393005824 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 65393005825 P-loop; other site 65393005826 Peptidase family M48; Region: Peptidase_M48; cl12018 65393005827 TIGR03442 family protein; Region: TIGR03442 65393005828 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 65393005829 putative active site [active] 65393005830 putative dimer interface [polypeptide binding]; other site 65393005831 TIGR03440 family protein; Region: unchr_TIGR03440 65393005832 DinB superfamily; Region: DinB_2; cl00986 65393005833 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 65393005834 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 65393005835 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 65393005836 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 65393005837 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 65393005838 DHH family; Region: DHH; pfam01368 65393005839 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_8; cd04621 65393005840 FOG: CBS domain [General function prediction only]; Region: COG0517 65393005841 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 65393005842 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 65393005843 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 65393005844 active site 65393005845 NTP binding site [chemical binding]; other site 65393005846 metal binding triad [ion binding]; metal-binding site 65393005847 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 65393005848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 65393005849 MORN repeat; Region: MORN; cl14787 65393005850 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 65393005851 MORN repeat; Region: MORN; cl14787 65393005852 MORN repeat; Region: MORN; cl14787 65393005853 Gram-negative bacterial tonB protein; Region: TonB; cl10048 65393005854 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 65393005855 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 65393005856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393005857 Helix-turn-helix domains; Region: HTH; cl00088 65393005858 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 65393005859 DNA binding site [nucleotide binding] 65393005860 Int/Topo IB signature motif; other site 65393005861 active site 65393005862 catalytic residues [active] 65393005863 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 65393005864 Di-iron ligands [ion binding]; other site 65393005865 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 65393005866 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 65393005867 BRO family, N-terminal domain; Region: Bro-N; cl10591 65393005868 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 65393005869 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393005870 active site 65393005871 NTP binding site [chemical binding]; other site 65393005872 metal binding triad [ion binding]; metal-binding site 65393005873 antibiotic binding site [chemical binding]; other site 65393005874 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 65393005875 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 65393005876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393005877 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 65393005878 GTP/Mg2+ binding site [chemical binding]; other site 65393005879 Switch I region; other site 65393005880 G2 box; other site 65393005881 Switch II region; other site 65393005882 G3 box; other site 65393005883 G4 box; other site 65393005884 G5 box; other site 65393005885 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 65393005886 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 65393005887 G1 box; other site 65393005888 GTP/Mg2+ binding site [chemical binding]; other site 65393005889 Switch I region; other site 65393005890 G2 box; other site 65393005891 Switch II region; other site 65393005892 G3 box; other site 65393005893 G4 box; other site 65393005894 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 65393005895 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 65393005896 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 65393005897 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393005898 putative active site [active] 65393005899 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393005900 putative active site [active] 65393005901 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393005902 RNA ligase; Region: RNA_lig_T4_1; cl09743 65393005903 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 65393005904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393005905 ATP binding site [chemical binding]; other site 65393005906 putative Mg++ binding site [ion binding]; other site 65393005907 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 65393005908 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005909 Predicted transcriptional regulator [Transcription]; Region: COG2378 65393005910 Helix-turn-helix domains; Region: HTH; cl00088 65393005911 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 65393005912 Reverse gyrase [DNA replication, recombination, and repair]; Region: COG1110 65393005913 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005914 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 65393005915 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 65393005916 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 65393005917 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 65393005918 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 65393005919 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 65393005920 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 65393005921 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 65393005922 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 65393005923 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 65393005924 active site 65393005925 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393005926 active site 65393005927 NTP binding site [chemical binding]; other site 65393005928 metal binding triad [ion binding]; metal-binding site 65393005929 antibiotic binding site [chemical binding]; other site 65393005930 Protein of unknown function DUF86; Region: DUF86; cl01031 65393005931 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 65393005932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005933 AAA-like domain; Region: AAA_10; pfam12846 65393005934 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 65393005935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005937 Walker B motif; other site 65393005938 DinB superfamily; Region: DinB_2; cl00986 65393005939 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 65393005940 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 65393005941 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 65393005942 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393005943 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 65393005944 DNA topoisomerase I; Validated; Region: PRK06599 65393005945 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 65393005946 active site 65393005947 interdomain interaction site; other site 65393005948 putative metal-binding site [ion binding]; other site 65393005949 nucleotide binding site [chemical binding]; other site 65393005950 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 65393005951 domain I; other site 65393005952 phosphate binding site [ion binding]; other site 65393005953 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 65393005954 domain II; other site 65393005955 domain III; other site 65393005956 nucleotide binding site [chemical binding]; other site 65393005957 DNA binding groove [nucleotide binding] 65393005958 catalytic site [active] 65393005959 domain IV; other site 65393005960 PemK-like protein; Region: PemK; cl00995 65393005961 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 65393005962 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005963 ATP binding site [chemical binding]; other site 65393005964 putative Mg++ binding site [ion binding]; other site 65393005965 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 65393005966 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393005967 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 65393005968 DNA binding site [nucleotide binding] 65393005969 Int/Topo IB signature motif; other site 65393005970 active site 65393005971 catalytic residues [active] 65393005972 Domain of unknown function DUF21; Region: DUF21; pfam01595 65393005973 FOG: CBS domain [General function prediction only]; Region: COG0517 65393005974 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 65393005975 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393005976 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393005977 threonine synthase; Validated; Region: PRK06260 65393005978 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 65393005979 homodimer interface [polypeptide binding]; other site 65393005980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393005981 catalytic residue [active] 65393005982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393005983 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 65393005984 gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529 65393005985 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 65393005986 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 65393005987 catalytic triad [active] 65393005988 dimer interface [polypeptide binding]; other site 65393005989 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 65393005990 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 65393005991 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 65393005992 dimerization interface [polypeptide binding]; other site 65393005993 DPS ferroxidase diiron center [ion binding]; other site 65393005994 ion pore; other site 65393005995 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 65393005996 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393005997 hypothetical protein; Provisional; Region: PRK06184 65393005998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393005999 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 65393006000 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 65393006001 MutS domain I; Region: MutS_I; pfam01624 65393006002 MutS domain II; Region: MutS_II; pfam05188 65393006003 MutS family domain IV; Region: MutS_IV; pfam05190 65393006004 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 65393006005 Walker A/P-loop; other site 65393006006 ATP binding site [chemical binding]; other site 65393006007 Q-loop/lid; other site 65393006008 ABC transporter signature motif; other site 65393006009 Walker B; other site 65393006010 D-loop; other site 65393006011 H-loop/switch region; other site 65393006012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 65393006013 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 65393006014 Protein of unknown function (DUF497); Region: DUF497; cl01108 65393006015 Transposase [DNA replication, recombination, and repair]; Region: COG5421 65393006016 DNA Polymerase alpha zinc finger; Region: zf-DNA_Pol; pfam08996 65393006017 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 65393006018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393006019 Walker A motif; other site 65393006020 ATP binding site [chemical binding]; other site 65393006021 Walker B motif; other site 65393006022 arginine finger; other site 65393006023 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 65393006024 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 65393006025 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 65393006026 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 65393006027 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 65393006028 NADH dehydrogenase; Region: NADHdh; cl00469 65393006029 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 65393006030 Transglycosylase; Region: Transgly; cl07896 65393006031 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 65393006032 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 65393006033 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 65393006034 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 65393006035 Flagellin N-methylase; Region: FliB; cl00497 65393006036 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 65393006037 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 65393006038 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 65393006039 Protein of unknown function (DUF512); Region: DUF512; pfam04459 65393006040 light-harvesting-like protein 3; Provisional; Region: PLN00014 65393006041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 65393006042 dimerization interface [polypeptide binding]; other site 65393006043 putative DNA binding site [nucleotide binding]; other site 65393006044 putative Zn2+ binding site [ion binding]; other site 65393006045 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 65393006046 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 65393006047 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 65393006048 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 65393006049 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 65393006050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 65393006051 ABC-ATPase subunit interface; other site 65393006052 dimer interface [polypeptide binding]; other site 65393006053 putative PBP binding regions; other site 65393006054 Cation efflux family; Region: Cation_efflux; cl00316 65393006055 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 65393006056 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 65393006057 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 65393006058 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 65393006059 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 65393006060 metal binding site [ion binding]; metal-binding site 65393006061 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 65393006062 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 65393006063 RNA binding surface [nucleotide binding]; other site 65393006064 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 65393006065 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 65393006066 Ligand binding site; other site 65393006067 Putative Catalytic site; other site 65393006068 DXD motif; other site 65393006069 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 65393006070 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 65393006071 active site 65393006072 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 65393006073 MAPEG family; Region: MAPEG; cl09190 65393006074 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 65393006075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006076 binding surface 65393006077 TPR motif; other site 65393006078 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 65393006079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006080 binding surface 65393006081 TPR motif; other site 65393006082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006083 binding surface 65393006084 TPR motif; other site 65393006085 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393006086 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 65393006087 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393006088 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 65393006089 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 65393006090 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 65393006091 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 65393006092 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 65393006093 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 65393006094 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393006095 ligand binding site [chemical binding]; other site 65393006096 flexible hinge region; other site 65393006097 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 65393006098 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 65393006099 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 65393006100 metal binding site [ion binding]; metal-binding site 65393006101 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 65393006102 active site 65393006103 catalytic triad [active] 65393006104 oxyanion hole [active] 65393006105 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393006106 META domain; Region: META; cl01245 65393006107 META domain; Region: META; cl01245 65393006108 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 65393006109 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 65393006110 Ligand Binding Site [chemical binding]; other site 65393006111 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 65393006112 active site 65393006113 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393006114 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 65393006115 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 65393006116 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 65393006117 putative active site [active] 65393006118 putative NTP binding site [chemical binding]; other site 65393006119 putative nucleic acid binding site [nucleotide binding]; other site 65393006120 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 65393006121 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 65393006122 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 65393006123 catalytic triad [active] 65393006124 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 65393006125 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 65393006126 Walker A/P-loop; other site 65393006127 ATP binding site [chemical binding]; other site 65393006128 Q-loop/lid; other site 65393006129 ABC transporter signature motif; other site 65393006130 Walker B; other site 65393006131 D-loop; other site 65393006132 H-loop/switch region; other site 65393006133 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 65393006134 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 65393006135 Archaeal ATPase; Region: Arch_ATPase; pfam01637 65393006136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393006137 Walker A motif; other site 65393006138 ATP binding site [chemical binding]; other site 65393006139 Walker B motif; other site 65393006140 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393006141 structural tetrad; other site 65393006142 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393006143 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393006144 structural tetrad; other site 65393006145 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393006146 structural tetrad; other site 65393006147 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 65393006148 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 65393006149 putative catalytic cysteine [active] 65393006150 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 65393006151 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 65393006152 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 65393006153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393006154 ATP binding site [chemical binding]; other site 65393006155 putative Mg++ binding site [ion binding]; other site 65393006156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393006157 nucleotide binding region [chemical binding]; other site 65393006158 ATP-binding site [chemical binding]; other site 65393006159 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 65393006160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393006161 S-adenosylmethionine binding site [chemical binding]; other site 65393006162 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 65393006163 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 65393006164 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393006165 structural tetrad; other site 65393006166 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 65393006167 MgtE intracellular N domain; Region: MgtE_N; cl15244 65393006168 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 65393006169 Divalent cation transporter; Region: MgtE; cl00786 65393006170 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 65393006171 HemN C-terminal region; Region: HemN_C; pfam06969 65393006172 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 65393006173 heme binding pocket [chemical binding]; other site 65393006174 heme ligand [chemical binding]; other site 65393006175 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 65393006176 diiron binding motif [ion binding]; other site 65393006177 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 65393006178 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 65393006179 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 65393006180 Dentin matrix protein 1 (DMP1); Region: DMP1; pfam07263 65393006181 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 65393006182 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 65393006183 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 65393006184 Surface antigen; Region: Bac_surface_Ag; cl03097 65393006185 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 65393006186 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 65393006187 ATP binding site [chemical binding]; other site 65393006188 active site 65393006189 substrate binding site [chemical binding]; other site 65393006190 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 65393006191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393006192 dimer interface [polypeptide binding]; other site 65393006193 conserved gate region; other site 65393006194 putative PBP binding loops; other site 65393006195 ABC-ATPase subunit interface; other site 65393006196 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393006197 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 65393006198 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 65393006199 FMN binding site [chemical binding]; other site 65393006200 active site 65393006201 substrate binding site [chemical binding]; other site 65393006202 catalytic residue [active] 65393006203 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 65393006204 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 65393006205 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 65393006206 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 65393006207 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 65393006208 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 65393006209 beta subunit interaction interface [polypeptide binding]; other site 65393006210 Walker A motif; other site 65393006211 ATP binding site [chemical binding]; other site 65393006212 Walker B motif; other site 65393006213 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 65393006214 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 65393006215 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 65393006216 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 65393006217 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 65393006218 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 65393006219 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 65393006220 ATP synthase subunit C; Region: ATP-synt_C; cl00466 65393006221 ATP synthase A chain; Region: ATP-synt_A; cl00413 65393006222 ATP synthase I chain; Region: ATP_synt_I; cl09170 65393006223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006224 binding surface 65393006225 TPR motif; other site 65393006226 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 65393006227 XisI protein; Region: XisI; pfam08869 65393006228 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 65393006229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393006230 S-adenosylmethionine binding site [chemical binding]; other site 65393006231 phycobillisome linker protein; Region: apcE; CHL00091 65393006232 Phycobilisome protein; Region: Phycobilisome; cl08227 65393006233 Phycobilisome protein; Region: Phycobilisome; cl08227 65393006234 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 65393006235 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 65393006236 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 65393006237 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393006238 putative active site [active] 65393006239 Phycobilisome protein; Region: Phycobilisome; cl08227 65393006240 Phycobilisome protein; Region: Phycobilisome; cl08227 65393006241 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 65393006242 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393006243 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393006244 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 65393006245 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 65393006246 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 65393006247 phosphate binding site [ion binding]; other site 65393006248 putative substrate binding pocket [chemical binding]; other site 65393006249 dimer interface [polypeptide binding]; other site 65393006250 Uncharacterized conserved protein [Function unknown]; Region: COG1912 65393006251 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 65393006252 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 65393006253 putative active site [active] 65393006254 dimerization interface [polypeptide binding]; other site 65393006255 putative tRNAtyr binding site [nucleotide binding]; other site 65393006256 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 65393006257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393006258 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 65393006259 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393006260 ligand binding site [chemical binding]; other site 65393006261 flexible hinge region; other site 65393006262 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 65393006263 catalytic core [active] 65393006264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 65393006265 catalytic core [active] 65393006266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 65393006267 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 65393006268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006269 active site 65393006270 phosphorylation site [posttranslational modification] 65393006271 intermolecular recognition site; other site 65393006272 Helix-turn-helix domains; Region: HTH; cl00088 65393006273 ornithine carbamoyltransferase; Provisional; Region: PRK00779 65393006274 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 65393006275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393006276 MatE; Region: MatE; cl10513 65393006277 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 65393006278 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 65393006279 putative dimer interface [polypeptide binding]; other site 65393006280 putative anticodon binding site; other site 65393006281 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 65393006282 homodimer interface [polypeptide binding]; other site 65393006283 motif 1; other site 65393006284 motif 2; other site 65393006285 active site 65393006286 motif 3; other site 65393006287 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393006288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006289 binding surface 65393006290 TPR motif; other site 65393006291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006292 binding surface 65393006293 TPR motif; other site 65393006294 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 65393006295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006296 binding surface 65393006297 TPR motif; other site 65393006298 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 65393006299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006300 binding surface 65393006301 TPR motif; other site 65393006302 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393006303 hypothetical protein; Validated; Region: PRK06769 65393006304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393006305 active site 65393006306 motif I; other site 65393006307 motif II; other site 65393006308 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 65393006309 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 65393006310 putative active site [active] 65393006311 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393006312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393006313 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393006314 Probable transposase; Region: OrfB_IS605; pfam01385 65393006315 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393006316 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 65393006317 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 65393006318 dimerization interface [polypeptide binding]; other site 65393006319 active site 65393006320 metal binding site [ion binding]; metal-binding site 65393006321 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 65393006322 dsRNA binding site [nucleotide binding]; other site 65393006323 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 65393006324 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 65393006325 pyranose oxidase; Region: pyranose_ox; TIGR02462 65393006326 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 65393006327 dimer interface [polypeptide binding]; other site 65393006328 catalytic triad [active] 65393006329 YcfA-like protein; Region: YcfA; cl00752 65393006330 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 65393006331 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 65393006332 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 65393006333 substrate binding site [chemical binding]; other site 65393006334 active site 65393006335 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 65393006336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393006337 NAD(P) binding site [chemical binding]; other site 65393006338 active site 65393006339 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 65393006340 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393006341 putative ADP-binding pocket [chemical binding]; other site 65393006342 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 65393006343 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 65393006344 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 65393006345 active site 65393006346 nucleophile elbow; other site 65393006347 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 65393006348 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 65393006349 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393006350 ligand binding site [chemical binding]; other site 65393006351 flexible hinge region; other site 65393006352 Helix-turn-helix domains; Region: HTH; cl00088 65393006353 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 65393006354 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 65393006355 Cytochrome P450; Region: p450; cl12078 65393006356 NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]; Region: CobT; COG2038 65393006357 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 65393006358 active site pocket [active] 65393006359 putative dimer interface [polypeptide binding]; other site 65393006360 putative cataytic base [active] 65393006361 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393006362 putative active site [active] 65393006363 proline aminopeptidase P II; Provisional; Region: PRK10879 65393006364 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 65393006365 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 65393006366 active site 65393006367 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 65393006368 Rhomboid family; Region: Rhomboid; cl11446 65393006369 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 65393006370 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 65393006371 NAD binding site [chemical binding]; other site 65393006372 dimerization interface [polypeptide binding]; other site 65393006373 product binding site; other site 65393006374 substrate binding site [chemical binding]; other site 65393006375 zinc binding site [ion binding]; other site 65393006376 catalytic residues [active] 65393006377 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393006378 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393006379 active site 65393006380 ATP binding site [chemical binding]; other site 65393006381 substrate binding site [chemical binding]; other site 65393006382 activation loop (A-loop); other site 65393006383 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 65393006384 GAF domain; Region: GAF; cl00853 65393006385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393006386 dimer interface [polypeptide binding]; other site 65393006387 phosphorylation site [posttranslational modification] 65393006388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393006389 ATP binding site [chemical binding]; other site 65393006390 Mg2+ binding site [ion binding]; other site 65393006391 G-X-G motif; other site 65393006392 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 65393006393 FOG: CBS domain [General function prediction only]; Region: COG0517 65393006394 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 65393006395 FOG: CBS domain [General function prediction only]; Region: COG0517 65393006396 FOG: CBS domain [General function prediction only]; Region: COG0517 65393006397 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 65393006398 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 65393006399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393006400 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 65393006401 putative active site [active] 65393006402 heme pocket [chemical binding]; other site 65393006403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393006404 dimer interface [polypeptide binding]; other site 65393006405 phosphorylation site [posttranslational modification] 65393006406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393006407 ATP binding site [chemical binding]; other site 65393006408 Mg2+ binding site [ion binding]; other site 65393006409 G-X-G motif; other site 65393006410 Response regulator receiver domain; Region: Response_reg; pfam00072 65393006411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006412 active site 65393006413 phosphorylation site [posttranslational modification] 65393006414 intermolecular recognition site; other site 65393006415 dimerization interface [polypeptide binding]; other site 65393006416 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 65393006417 catalytic triad [active] 65393006418 conserved cis-peptide bond; other site 65393006419 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 65393006420 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 65393006421 cofactor binding site; other site 65393006422 DNA binding site [nucleotide binding] 65393006423 substrate interaction site [chemical binding]; other site 65393006424 Arginase family; Region: Arginase; cl00306 65393006425 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 65393006426 putative nucleotide binding site [chemical binding]; other site 65393006427 uridine monophosphate binding site [chemical binding]; other site 65393006428 homohexameric interface [polypeptide binding]; other site 65393006429 ribosome recycling factor; Reviewed; Region: frr; PRK00083 65393006430 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 65393006431 hinge region; other site 65393006432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 65393006433 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 65393006434 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 65393006435 Walker A/P-loop; other site 65393006436 ATP binding site [chemical binding]; other site 65393006437 Q-loop/lid; other site 65393006438 ABC transporter signature motif; other site 65393006439 Walker B; other site 65393006440 D-loop; other site 65393006441 H-loop/switch region; other site 65393006442 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 65393006443 Walker A/P-loop; other site 65393006444 ATP binding site [chemical binding]; other site 65393006445 Q-loop/lid; other site 65393006446 ABC transporter signature motif; other site 65393006447 Walker B; other site 65393006448 D-loop; other site 65393006449 H-loop/switch region; other site 65393006450 Cobalt transport protein; Region: CbiQ; cl00463 65393006451 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 65393006452 DNA binding residues [nucleotide binding] 65393006453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393006454 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 65393006455 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 65393006456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393006457 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 65393006458 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 65393006459 glutamine binding [chemical binding]; other site 65393006460 catalytic triad [active] 65393006461 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 65393006462 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 65393006463 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 65393006464 peptide chain release factor 2; Validated; Region: prfB; PRK00578 65393006465 RF-1 domain; Region: RF-1; cl02875 65393006466 RF-1 domain; Region: RF-1; cl02875 65393006467 TMAO/DMSO reductase; Reviewed; Region: PRK05363 65393006468 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 65393006469 Moco binding site; other site 65393006470 metal coordination site [ion binding]; other site 65393006471 CHAD domain; Region: CHAD; cl10506 65393006472 E3 Ubiquitin ligase; Region: GIDE; pfam12483 65393006473 galacturonosyltransferase; Region: PLN02523 65393006474 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 65393006475 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 65393006476 active site 65393006477 HIGH motif; other site 65393006478 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 65393006479 KMSKS motif; other site 65393006480 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 65393006481 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393006482 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393006483 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393006484 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393006485 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393006486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393006487 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 65393006488 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 65393006489 Walker A/P-loop; other site 65393006490 ATP binding site [chemical binding]; other site 65393006491 Q-loop/lid; other site 65393006492 ABC transporter signature motif; other site 65393006493 Walker B; other site 65393006494 D-loop; other site 65393006495 H-loop/switch region; other site 65393006496 DevC protein; Region: devC; TIGR01185 65393006497 FtsX-like permease family; Region: FtsX; pfam02687 65393006498 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 65393006499 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 65393006500 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 65393006501 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 65393006502 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 65393006503 malonyl-CoA binding site [chemical binding]; other site 65393006504 dimer interface [polypeptide binding]; other site 65393006505 active site 65393006506 product binding site; other site 65393006507 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 65393006508 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 65393006509 active site 65393006510 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 65393006511 Acyl transferase domain; Region: Acyl_transf_1; cl08282 65393006512 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393006513 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 65393006514 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393006515 acyl-CoA synthetase; Validated; Region: PRK05850 65393006516 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393006517 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 65393006518 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 65393006519 NAD(P) binding site [chemical binding]; other site 65393006520 catalytic residues [active] 65393006521 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393006522 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393006523 active site 65393006524 ATP binding site [chemical binding]; other site 65393006525 substrate binding site [chemical binding]; other site 65393006526 activation loop (A-loop); other site 65393006527 Predicted ATPase [General function prediction only]; Region: COG3899 65393006528 GAF domain; Region: GAF; cl00853 65393006529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393006530 PAS fold; Region: PAS_4; pfam08448 65393006531 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 65393006532 dimer interface [polypeptide binding]; other site 65393006533 [2Fe-2S] cluster binding site [ion binding]; other site 65393006534 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 65393006535 MoaE homodimer interface [polypeptide binding]; other site 65393006536 MoaD interaction [polypeptide binding]; other site 65393006537 active site residues [active] 65393006538 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 65393006539 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 65393006540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393006541 GUN4-like; Region: GUN4; pfam05419 65393006542 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 65393006543 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 65393006544 CemA family; Region: CemA; cl03855 65393006545 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 65393006546 Protein export membrane protein; Region: SecD_SecF; cl14618 65393006547 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 65393006548 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 65393006549 Hexamer interface [polypeptide binding]; other site 65393006550 Hexagonal pore residue; other site 65393006551 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 65393006552 Hexamer interface [polypeptide binding]; other site 65393006553 Hexagonal pore residue; other site 65393006554 Protein of unknown function (DUF433); Region: DUF433; cl01030 65393006555 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393006556 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393006557 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393006558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393006559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006560 active site 65393006561 phosphorylation site [posttranslational modification] 65393006562 intermolecular recognition site; other site 65393006563 dimerization interface [polypeptide binding]; other site 65393006564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393006565 DNA binding site [nucleotide binding] 65393006566 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 65393006567 putative binding surface; other site 65393006568 active site 65393006569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006570 active site 65393006571 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 65393006572 phosphorylation site [posttranslational modification] 65393006573 intermolecular recognition site; other site 65393006574 dimerization interface [polypeptide binding]; other site 65393006575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006576 active site 65393006577 phosphorylation site [posttranslational modification] 65393006578 intermolecular recognition site; other site 65393006579 dimerization interface [polypeptide binding]; other site 65393006580 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393006581 metal binding site [ion binding]; metal-binding site 65393006582 active site 65393006583 I-site; other site 65393006584 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 65393006585 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 65393006586 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393006587 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 65393006588 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 65393006589 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 65393006590 putative NAD(P) binding site [chemical binding]; other site 65393006591 active site 65393006592 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 65393006593 homotrimer interaction site [polypeptide binding]; other site 65393006594 zinc binding site [ion binding]; other site 65393006595 CDP-binding sites; other site 65393006596 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 65393006597 active site 65393006598 catalytic motif [active] 65393006599 Zn binding site [ion binding]; other site 65393006600 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393006601 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393006602 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 65393006603 Fatty acid desaturase; Region: FA_desaturase; pfam00487 65393006604 putative di-iron ligands [ion binding]; other site 65393006605 Cupin domain; Region: Cupin_2; cl09118 65393006606 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393006607 hypothetical protein; Reviewed; Region: PRK09588 65393006608 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 65393006609 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 65393006610 Domain of unknown function DUF20; Region: UPF0118; cl00465 65393006611 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 65393006612 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 65393006613 Domain of unknown function DUF28; Region: DUF28; cl00361 65393006614 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 65393006615 active site 65393006616 substrate-binding site [chemical binding]; other site 65393006617 metal-binding site [ion binding] 65393006618 ATP binding site [chemical binding]; other site 65393006619 Domain of unknown function (DUF205); Region: DUF205; cl00410 65393006620 phosphoenolpyruvate synthase; Validated; Region: PRK06241 65393006621 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 65393006622 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 65393006623 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 65393006624 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 65393006625 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 65393006626 putative binding surface; other site 65393006627 active site 65393006628 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 65393006629 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 65393006630 putative binding surface; other site 65393006631 active site 65393006632 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 65393006633 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 65393006634 putative binding surface; other site 65393006635 active site 65393006636 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 65393006637 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 65393006638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393006639 ATP binding site [chemical binding]; other site 65393006640 Mg2+ binding site [ion binding]; other site 65393006641 G-X-G motif; other site 65393006642 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 65393006643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006644 Response regulator receiver domain; Region: Response_reg; pfam00072 65393006645 active site 65393006646 phosphorylation site [posttranslational modification] 65393006647 intermolecular recognition site; other site 65393006648 dimerization interface [polypeptide binding]; other site 65393006649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 65393006650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393006651 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393006652 GAF domain; Region: GAF; cl00853 65393006653 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 65393006654 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 65393006655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393006656 dimerization interface [polypeptide binding]; other site 65393006657 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393006658 GAF domain; Region: GAF; cl00853 65393006659 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393006660 GAF domain; Region: GAF; cl00853 65393006661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393006662 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 65393006663 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 65393006664 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 65393006665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006666 Response regulator receiver domain; Region: Response_reg; pfam00072 65393006667 active site 65393006668 phosphorylation site [posttranslational modification] 65393006669 intermolecular recognition site; other site 65393006670 dimerization interface [polypeptide binding]; other site 65393006671 Response regulator receiver domain; Region: Response_reg; pfam00072 65393006672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006673 active site 65393006674 phosphorylation site [posttranslational modification] 65393006675 intermolecular recognition site; other site 65393006676 dimerization interface [polypeptide binding]; other site 65393006677 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 65393006678 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 65393006679 putative binding surface; other site 65393006680 active site 65393006681 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 65393006682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393006683 ATP binding site [chemical binding]; other site 65393006684 Mg2+ binding site [ion binding]; other site 65393006685 G-X-G motif; other site 65393006686 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 65393006687 Response regulator receiver domain; Region: Response_reg; pfam00072 65393006688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006689 active site 65393006690 phosphorylation site [posttranslational modification] 65393006691 intermolecular recognition site; other site 65393006692 dimerization interface [polypeptide binding]; other site 65393006693 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 65393006694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393006695 dimerization interface [polypeptide binding]; other site 65393006696 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 65393006697 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 65393006698 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 65393006699 Response regulator receiver domain; Region: Response_reg; pfam00072 65393006700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006701 active site 65393006702 phosphorylation site [posttranslational modification] 65393006703 intermolecular recognition site; other site 65393006704 dimerization interface [polypeptide binding]; other site 65393006705 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 65393006706 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 65393006707 Walker A/P-loop; other site 65393006708 ATP binding site [chemical binding]; other site 65393006709 Q-loop/lid; other site 65393006710 ABC transporter signature motif; other site 65393006711 Walker B; other site 65393006712 D-loop; other site 65393006713 H-loop/switch region; other site 65393006714 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393006715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393006716 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 65393006717 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 65393006718 Predicted GTPase [General function prediction only]; Region: COG2403 65393006719 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393006720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393006721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393006722 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 65393006723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393006724 dimer interface [polypeptide binding]; other site 65393006725 conserved gate region; other site 65393006726 putative PBP binding loops; other site 65393006727 ABC-ATPase subunit interface; other site 65393006728 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 65393006729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393006730 dimer interface [polypeptide binding]; other site 65393006731 conserved gate region; other site 65393006732 putative PBP binding loops; other site 65393006733 ABC-ATPase subunit interface; other site 65393006734 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 65393006735 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 65393006736 Walker A/P-loop; other site 65393006737 ATP binding site [chemical binding]; other site 65393006738 Q-loop/lid; other site 65393006739 ABC transporter signature motif; other site 65393006740 Walker B; other site 65393006741 D-loop; other site 65393006742 H-loop/switch region; other site 65393006743 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 65393006744 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 65393006745 Walker A/P-loop; other site 65393006746 ATP binding site [chemical binding]; other site 65393006747 Q-loop/lid; other site 65393006748 ABC transporter signature motif; other site 65393006749 Walker B; other site 65393006750 D-loop; other site 65393006751 H-loop/switch region; other site 65393006752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393006753 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 65393006754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393006755 dimer interface [polypeptide binding]; other site 65393006756 conserved gate region; other site 65393006757 ABC-ATPase subunit interface; other site 65393006758 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 65393006759 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 65393006760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393006761 ABC-ATPase subunit interface; other site 65393006762 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 65393006763 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 65393006764 Walker A/P-loop; other site 65393006765 ATP binding site [chemical binding]; other site 65393006766 Q-loop/lid; other site 65393006767 ABC transporter signature motif; other site 65393006768 Walker B; other site 65393006769 D-loop; other site 65393006770 H-loop/switch region; other site 65393006771 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 65393006772 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 65393006773 dimer interface [polypeptide binding]; other site 65393006774 tetramer interface [polypeptide binding]; other site 65393006775 PYR/PP interface [polypeptide binding]; other site 65393006776 TPP binding site [chemical binding]; other site 65393006777 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 65393006778 TPP-binding site; other site 65393006779 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 65393006780 active site 65393006781 nucleophile elbow; other site 65393006782 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 65393006783 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 65393006784 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 65393006785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393006786 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393006787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393006788 DNA binding residues [nucleotide binding] 65393006789 Dehydratase family; Region: ILVD_EDD; cl00340 65393006790 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 65393006791 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 65393006792 RNA polymerase sigma factor; Validated; Region: PRK05949 65393006793 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 65393006794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393006795 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393006796 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393006797 DNA binding residues [nucleotide binding] 65393006798 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 65393006799 ligand-binding site [chemical binding]; other site 65393006800 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 65393006801 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 65393006802 active site 65393006803 metal binding site [ion binding]; metal-binding site 65393006804 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 65393006805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393006806 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 65393006807 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 65393006808 Cation transport protein; Region: TrkH; cl10514 65393006809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393006810 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393006811 H+ Antiporter protein; Region: 2A0121; TIGR00900 65393006812 Recombination protein O N terminal; Region: RecO_N; pfam11967 65393006813 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 65393006814 Recombination protein O C terminal; Region: RecO_C; pfam02565 65393006815 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 65393006816 intersubunit interface [polypeptide binding]; other site 65393006817 active site 65393006818 catalytic residue [active] 65393006819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393006820 S-adenosylmethionine binding site [chemical binding]; other site 65393006821 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 65393006822 dimanganese center [ion binding]; other site 65393006823 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 65393006824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393006825 FeS/SAM binding site; other site 65393006826 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 65393006827 Pyruvate formate lyase 1; Region: PFL1; cd01678 65393006828 coenzyme A binding site [chemical binding]; other site 65393006829 active site 65393006830 catalytic residues [active] 65393006831 glycine loop; other site 65393006832 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 65393006833 PAS fold; Region: PAS_4; pfam08448 65393006834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393006835 PAS domain S-box; Region: sensory_box; TIGR00229 65393006836 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393006837 GAF domain; Region: GAF; cl00853 65393006838 PAS domain S-box; Region: sensory_box; TIGR00229 65393006839 putative diguanylate cyclase; Provisional; Region: PRK09776 65393006840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393006841 putative active site [active] 65393006842 heme pocket [chemical binding]; other site 65393006843 putative diguanylate cyclase; Provisional; Region: PRK09776 65393006844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393006845 putative active site [active] 65393006846 heme pocket [chemical binding]; other site 65393006847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393006848 dimer interface [polypeptide binding]; other site 65393006849 phosphorylation site [posttranslational modification] 65393006850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393006851 ATP binding site [chemical binding]; other site 65393006852 Mg2+ binding site [ion binding]; other site 65393006853 G-X-G motif; other site 65393006854 Response regulator receiver domain; Region: Response_reg; pfam00072 65393006855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006856 active site 65393006857 phosphorylation site [posttranslational modification] 65393006858 intermolecular recognition site; other site 65393006859 dimerization interface [polypeptide binding]; other site 65393006860 Domain of unknown function DUF37; Region: DUF37; cl00506 65393006861 Response regulator receiver domain; Region: Response_reg; pfam00072 65393006862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006863 active site 65393006864 phosphorylation site [posttranslational modification] 65393006865 intermolecular recognition site; other site 65393006866 dimerization interface [polypeptide binding]; other site 65393006867 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393006868 GAF domain; Region: GAF; cl00853 65393006869 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 65393006870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393006871 dimer interface [polypeptide binding]; other site 65393006872 phosphorylation site [posttranslational modification] 65393006873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393006874 ATP binding site [chemical binding]; other site 65393006875 Mg2+ binding site [ion binding]; other site 65393006876 G-X-G motif; other site 65393006877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006878 Response regulator receiver domain; Region: Response_reg; pfam00072 65393006879 active site 65393006880 phosphorylation site [posttranslational modification] 65393006881 intermolecular recognition site; other site 65393006882 dimerization interface [polypeptide binding]; other site 65393006883 Response regulator receiver domain; Region: Response_reg; pfam00072 65393006884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006885 active site 65393006886 phosphorylation site [posttranslational modification] 65393006887 intermolecular recognition site; other site 65393006888 dimerization interface [polypeptide binding]; other site 65393006889 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 65393006890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393006891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393006892 active site 65393006893 phosphorylation site [posttranslational modification] 65393006894 intermolecular recognition site; other site 65393006895 dimerization interface [polypeptide binding]; other site 65393006896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393006897 DNA binding site [nucleotide binding] 65393006898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 65393006899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393006900 dimerization interface [polypeptide binding]; other site 65393006901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393006902 dimer interface [polypeptide binding]; other site 65393006903 phosphorylation site [posttranslational modification] 65393006904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393006905 ATP binding site [chemical binding]; other site 65393006906 Mg2+ binding site [ion binding]; other site 65393006907 G-X-G motif; other site 65393006908 Cupin domain; Region: Cupin_2; cl09118 65393006909 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 65393006910 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 65393006911 NAD(P) binding site [chemical binding]; other site 65393006912 homotetramer interface [polypeptide binding]; other site 65393006913 homodimer interface [polypeptide binding]; other site 65393006914 active site 65393006915 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 65393006916 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 65393006917 ring oligomerisation interface [polypeptide binding]; other site 65393006918 ATP/Mg binding site [chemical binding]; other site 65393006919 stacking interactions; other site 65393006920 hinge regions; other site 65393006921 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 65393006922 RNA/DNA binding site [nucleotide binding]; other site 65393006923 RRM dimerization site [polypeptide binding]; other site 65393006924 heat shock protein 90; Provisional; Region: PRK05218 65393006925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393006926 ATP binding site [chemical binding]; other site 65393006927 Mg2+ binding site [ion binding]; other site 65393006928 G-X-G motif; other site 65393006929 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 65393006930 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 65393006931 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 65393006932 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 65393006933 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 65393006934 N-acetyl-D-glucosamine binding site [chemical binding]; other site 65393006935 catalytic residue [active] 65393006936 Uncharacterized conserved protein [Function unknown]; Region: COG1912 65393006937 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 65393006938 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 65393006939 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393006940 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393006941 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 65393006942 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 65393006943 active site 65393006944 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 65393006945 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 65393006946 putative ligand binding site [chemical binding]; other site 65393006947 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 65393006948 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 65393006949 TM-ABC transporter signature motif; other site 65393006950 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 65393006951 TM-ABC transporter signature motif; other site 65393006952 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 65393006953 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 65393006954 Walker A/P-loop; other site 65393006955 ATP binding site [chemical binding]; other site 65393006956 Q-loop/lid; other site 65393006957 ABC transporter signature motif; other site 65393006958 Walker B; other site 65393006959 D-loop; other site 65393006960 H-loop/switch region; other site 65393006961 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 65393006962 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 65393006963 Walker A/P-loop; other site 65393006964 ATP binding site [chemical binding]; other site 65393006965 Q-loop/lid; other site 65393006966 ABC transporter signature motif; other site 65393006967 Walker B; other site 65393006968 D-loop; other site 65393006969 H-loop/switch region; other site 65393006970 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 65393006971 Fasciclin domain; Region: Fasciclin; cl02663 65393006972 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 65393006973 active site 65393006974 multimer interface [polypeptide binding]; other site 65393006975 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 65393006976 DHH family; Region: DHH; pfam01368 65393006977 DHHA1 domain; Region: DHHA1; pfam02272 65393006978 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 65393006979 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 65393006980 Ligand binding site; other site 65393006981 Putative Catalytic site; other site 65393006982 DXD motif; other site 65393006983 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 65393006984 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 65393006985 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 65393006986 substrate binding pocket [chemical binding]; other site 65393006987 membrane-bound complex binding site; other site 65393006988 hinge residues; other site 65393006989 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393006990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006991 TPR motif; other site 65393006992 binding surface 65393006993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006994 binding surface 65393006995 TPR motif; other site 65393006996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393006997 binding surface 65393006998 TPR motif; other site 65393006999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393007000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393007001 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 65393007002 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393007003 GMP synthase; Reviewed; Region: guaA; PRK00074 65393007004 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 65393007005 AMP/PPi binding site [chemical binding]; other site 65393007006 candidate oxyanion hole; other site 65393007007 catalytic triad [active] 65393007008 potential glutamine specificity residues [chemical binding]; other site 65393007009 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 65393007010 ATP Binding subdomain [chemical binding]; other site 65393007011 Ligand Binding sites [chemical binding]; other site 65393007012 Dimerization subdomain; other site 65393007013 response regulator FixJ; Provisional; Region: fixJ; PRK09390 65393007014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393007015 active site 65393007016 phosphorylation site [posttranslational modification] 65393007017 intermolecular recognition site; other site 65393007018 dimerization interface [polypeptide binding]; other site 65393007019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393007020 DNA binding residues [nucleotide binding] 65393007021 dimerization interface [polypeptide binding]; other site 65393007022 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 65393007023 dimer interface [polypeptide binding]; other site 65393007024 [2Fe-2S] cluster binding site [ion binding]; other site 65393007025 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 65393007026 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 65393007027 nucleotide binding pocket [chemical binding]; other site 65393007028 K-X-D-G motif; other site 65393007029 catalytic site [active] 65393007030 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 65393007031 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 65393007032 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 65393007033 Dimer interface [polypeptide binding]; other site 65393007034 BRCT sequence motif; other site 65393007035 Fic/DOC family; Region: Fic; cl00960 65393007036 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393007037 putative active site [active] 65393007038 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 65393007039 nudix motif; other site 65393007040 argininosuccinate lyase; Provisional; Region: PRK00855 65393007041 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 65393007042 active sites [active] 65393007043 tetramer interface [polypeptide binding]; other site 65393007044 GAF domain; Region: GAF; cl00853 65393007045 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 65393007046 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 65393007047 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 65393007048 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 65393007049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393007050 active site 65393007051 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 65393007052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393007053 binding surface 65393007054 TPR motif; other site 65393007055 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 65393007056 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 65393007057 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 65393007058 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 65393007059 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 65393007060 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 65393007061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393007062 binding surface 65393007063 TPR motif; other site 65393007064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393007065 binding surface 65393007066 TPR motif; other site 65393007067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393007068 binding surface 65393007069 TPR motif; other site 65393007070 AIR carboxylase; Region: AIRC; cl00310 65393007071 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 65393007072 active site 65393007073 dimer interface [polypeptide binding]; other site 65393007074 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 65393007075 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 65393007076 Transglycosylase; Region: Transgly; cl07896 65393007077 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 65393007078 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 65393007079 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 65393007080 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 65393007081 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 65393007082 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 65393007083 thiS-thiF/thiG interaction site; other site 65393007084 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 65393007085 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 65393007086 thiamine phosphate binding site [chemical binding]; other site 65393007087 active site 65393007088 pyrophosphate binding site [ion binding]; other site 65393007089 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 65393007090 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 65393007091 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 65393007092 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 65393007093 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 65393007094 active site 65393007095 Zn binding site [ion binding]; other site 65393007096 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393007097 trehalose synthase; Region: treS_nterm; TIGR02456 65393007098 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 65393007099 active site 65393007100 catalytic site [active] 65393007101 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 65393007102 HEPN domain; Region: HEPN; cl00824 65393007103 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393007104 active site 65393007105 NTP binding site [chemical binding]; other site 65393007106 metal binding triad [ion binding]; metal-binding site 65393007107 antibiotic binding site [chemical binding]; other site 65393007108 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 65393007109 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 65393007110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393007111 putative substrate translocation pore; other site 65393007112 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 65393007113 aromatic arch; other site 65393007114 DCoH dimer interaction site [polypeptide binding]; other site 65393007115 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 65393007116 DCoH tetramer interaction site [polypeptide binding]; other site 65393007117 substrate binding site [chemical binding]; other site 65393007118 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 65393007119 Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; Region: FRQ1; COG5126 65393007120 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 65393007121 Ca2+ binding site [ion binding]; other site 65393007122 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 65393007123 Ca2+ binding site [ion binding]; other site 65393007124 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 65393007125 catalytic triad [active] 65393007126 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393007127 active site 65393007128 ATP binding site [chemical binding]; other site 65393007129 substrate binding site [chemical binding]; other site 65393007130 activation loop (A-loop); other site 65393007131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393007132 sulfite reductase subunit beta; Provisional; Region: PRK13504 65393007133 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 65393007134 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 65393007135 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393007136 phosphopeptide binding site; other site 65393007137 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393007138 phosphopeptide binding site; other site 65393007139 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 65393007140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393007141 Walker A/P-loop; other site 65393007142 ATP binding site [chemical binding]; other site 65393007143 Q-loop/lid; other site 65393007144 ABC transporter signature motif; other site 65393007145 Walker B; other site 65393007146 D-loop; other site 65393007147 H-loop/switch region; other site 65393007148 ABC-2 type transporter; Region: ABC2_membrane; cl11417 65393007149 6-phosphofructokinase; Provisional; Region: PRK03202 65393007150 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 65393007151 active site 65393007152 ADP/pyrophosphate binding site [chemical binding]; other site 65393007153 dimerization interface [polypeptide binding]; other site 65393007154 allosteric effector site; other site 65393007155 fructose-1,6-bisphosphate binding site; other site 65393007156 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 65393007157 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 65393007158 DNA binding residues [nucleotide binding] 65393007159 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 65393007160 catalytic residues [active] 65393007161 catalytic nucleophile [active] 65393007162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393007163 Probable transposase; Region: OrfB_IS605; pfam01385 65393007164 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393007165 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393007166 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007167 secreted effector protein PipB2; Provisional; Region: PRK15196 65393007168 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007169 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 65393007170 MPT binding site; other site 65393007171 trimer interface [polypeptide binding]; other site 65393007172 Psb28 protein; Region: Psb28; cl04326 65393007173 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 65393007174 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 65393007175 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 65393007176 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393007177 catalytic residue [active] 65393007178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393007179 binding surface 65393007180 TPR motif; other site 65393007181 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 65393007182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393007183 binding surface 65393007184 TPR motif; other site 65393007185 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 65393007186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393007187 binding surface 65393007188 TPR motif; other site 65393007189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393007190 binding surface 65393007191 TPR motif; other site 65393007192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393007193 binding surface 65393007194 TPR motif; other site 65393007195 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393007196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393007197 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393007198 Probable transposase; Region: OrfB_IS605; pfam01385 65393007199 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393007200 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 65393007201 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 65393007202 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 65393007203 active site 65393007204 ATP binding site [chemical binding]; other site 65393007205 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 65393007206 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 65393007207 Substrate binding site; other site 65393007208 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 65393007209 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007210 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007211 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 65393007212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393007213 active site 65393007214 phosphorylation site [posttranslational modification] 65393007215 intermolecular recognition site; other site 65393007216 dimerization interface [polypeptide binding]; other site 65393007217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393007218 DNA binding residues [nucleotide binding] 65393007219 dimerization interface [polypeptide binding]; other site 65393007220 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 65393007221 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 65393007222 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 65393007223 Protein of unknown function (DUF1626); Region: DUF1626; pfam07788 65393007224 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 65393007225 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 65393007226 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 65393007227 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 65393007228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393007229 FeS/SAM binding site; other site 65393007230 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 65393007231 putative active site [active] 65393007232 catalytic site [active] 65393007233 putative substrate binding site [chemical binding]; other site 65393007234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393007235 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393007236 Probable transposase; Region: OrfB_IS605; pfam01385 65393007237 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393007238 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 65393007239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393007240 Flavin Reductases; Region: FlaRed; cl00801 65393007241 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 65393007242 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 65393007243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393007244 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 65393007245 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 65393007246 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 65393007247 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 65393007248 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 65393007249 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 65393007250 dimer interface [polypeptide binding]; other site 65393007251 FMN binding site [chemical binding]; other site 65393007252 fumarate hydratase; Reviewed; Region: fumC; PRK00485 65393007253 Class II fumarases; Region: Fumarase_classII; cd01362 65393007254 active site 65393007255 tetramer interface [polypeptide binding]; other site 65393007256 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 65393007257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 65393007258 inhibitor-cofactor binding pocket; inhibition site 65393007259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393007260 catalytic residue [active] 65393007261 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007262 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007263 EamA-like transporter family; Region: EamA; cl01037 65393007264 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 65393007265 D1 interface; other site 65393007266 chlorophyll binding site; other site 65393007267 pheophytin binding site; other site 65393007268 beta carotene binding site; other site 65393007269 cytochrome b559 beta interface; other site 65393007270 quinone binding site; other site 65393007271 cytochrome b559 alpha interface; other site 65393007272 protein J interface; other site 65393007273 protein H interface; other site 65393007274 protein X interface; other site 65393007275 core light harvesting protein interface; other site 65393007276 protein L interface; other site 65393007277 CP43 interface; other site 65393007278 protein T interface; other site 65393007279 Fe binding site [ion binding]; other site 65393007280 protein M interface; other site 65393007281 Mn-stabilizing polypeptide interface; other site 65393007282 bromide binding site; other site 65393007283 cytochrome c-550 interface; other site 65393007284 hypothetical protein; Provisional; Region: PRK13683 65393007285 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 65393007286 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 65393007287 Walker A/P-loop; other site 65393007288 ATP binding site [chemical binding]; other site 65393007289 Q-loop/lid; other site 65393007290 ABC transporter signature motif; other site 65393007291 Walker B; other site 65393007292 D-loop; other site 65393007293 H-loop/switch region; other site 65393007294 YacP-like NYN domain; Region: NYN_YacP; cl01491 65393007295 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 65393007296 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 65393007297 [2Fe-2S] cluster binding site [ion binding]; other site 65393007298 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 65393007299 hydrophobic ligand binding site; other site 65393007300 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 65393007301 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 65393007302 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393007303 catalytic residue [active] 65393007304 GH3 auxin-responsive promoter; Region: GH3; cl04006 65393007305 Cupin domain; Region: Cupin_2; cl09118 65393007306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393007307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 65393007308 putative substrate translocation pore; other site 65393007309 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 65393007310 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 65393007311 putative NADP binding site [chemical binding]; other site 65393007312 putative substrate binding site [chemical binding]; other site 65393007313 active site 65393007314 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007315 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007316 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007317 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 65393007318 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 65393007319 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 65393007320 active site 65393007321 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393007322 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 65393007323 phosphatidylserine decarboxylase; Region: PLN02964 65393007324 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 65393007325 AsmA family; Region: AsmA; pfam05170 65393007326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 65393007327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 65393007328 Family of unknown function (DUF490); Region: DUF490; pfam04357 65393007329 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 65393007330 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 65393007331 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 65393007332 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 65393007333 Ligand Binding Site [chemical binding]; other site 65393007334 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 65393007335 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 65393007336 Response regulator receiver domain; Region: Response_reg; pfam00072 65393007337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393007338 active site 65393007339 phosphorylation site [posttranslational modification] 65393007340 intermolecular recognition site; other site 65393007341 dimerization interface [polypeptide binding]; other site 65393007342 Response regulator receiver domain; Region: Response_reg; pfam00072 65393007343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393007344 active site 65393007345 phosphorylation site [posttranslational modification] 65393007346 intermolecular recognition site; other site 65393007347 dimerization interface [polypeptide binding]; other site 65393007348 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 65393007349 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393007350 dimerization interface [polypeptide binding]; other site 65393007351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393007352 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 65393007353 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 65393007354 Domain of unknown function DUF140; Region: DUF140; cl00510 65393007355 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 65393007356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393007357 active site 65393007358 phosphorylation site [posttranslational modification] 65393007359 intermolecular recognition site; other site 65393007360 dimerization interface [polypeptide binding]; other site 65393007361 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 65393007362 tetramer interface [polypeptide binding]; other site 65393007363 dimer interface [polypeptide binding]; other site 65393007364 circadian clock protein KaiC; Reviewed; Region: PRK09302 65393007365 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 65393007366 Walker A motif; other site 65393007367 ATP binding site [chemical binding]; other site 65393007368 Walker B motif; other site 65393007369 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393007370 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393007371 Walker A motif; other site 65393007372 ATP binding site [chemical binding]; other site 65393007373 Walker B motif; other site 65393007374 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 65393007375 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 65393007376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 65393007377 substrate binding pocket [chemical binding]; other site 65393007378 membrane-bound complex binding site; other site 65393007379 hinge residues; other site 65393007380 Domain of unknown function DUF20; Region: UPF0118; cl00465 65393007381 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393007382 putative active site [active] 65393007383 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393007384 phosphopeptide binding site; other site 65393007385 Transglycosylase; Region: Transgly; cl07896 65393007386 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 65393007387 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 65393007388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393007389 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 65393007390 Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194 65393007391 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 65393007392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393007393 Coenzyme A binding pocket [chemical binding]; other site 65393007394 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 65393007395 Septum formation topological specificity factor MinE; Region: MinE; cl00538 65393007396 septum site-determining protein MinD; Region: minD_bact; TIGR01968 65393007397 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 65393007398 Switch I; other site 65393007399 Switch II; other site 65393007400 septum formation inhibitor; Reviewed; Region: minC; PRK00513 65393007401 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 65393007402 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 65393007403 TIGR03790 family protein; Region: TIGR03790 65393007404 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 65393007405 SelR domain; Region: SelR; cl00369 65393007406 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 65393007407 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 65393007408 Survival protein SurE; Region: SurE; cl00448 65393007409 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 65393007410 active site 65393007411 metal binding site [ion binding]; metal-binding site 65393007412 YGGT family; Region: YGGT; cl00508 65393007413 Domain of unknown function DUF20; Region: UPF0118; cl00465 65393007414 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393007415 metal binding site [ion binding]; metal-binding site 65393007416 active site 65393007417 I-site; other site 65393007418 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 65393007419 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 65393007420 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393007421 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 65393007422 ribonuclease PH; Reviewed; Region: rph; PRK00173 65393007423 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 65393007424 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 65393007425 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 65393007426 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 65393007427 Walker A/P-loop; other site 65393007428 ATP binding site [chemical binding]; other site 65393007429 Q-loop/lid; other site 65393007430 ABC transporter signature motif; other site 65393007431 Walker B; other site 65393007432 D-loop; other site 65393007433 H-loop/switch region; other site 65393007434 mce related protein; Region: MCE; cl15431 65393007435 mce related protein; Region: MCE; cl15431 65393007436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 65393007437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 65393007438 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 65393007439 CVNH domain; Region: CVNH; pfam08881 65393007440 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 65393007441 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 65393007442 dimer interface [polypeptide binding]; other site 65393007443 anticodon binding site; other site 65393007444 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 65393007445 homodimer interface [polypeptide binding]; other site 65393007446 motif 1; other site 65393007447 active site 65393007448 motif 2; other site 65393007449 GAD domain; Region: GAD; pfam02938 65393007450 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 65393007451 active site 65393007452 motif 3; other site 65393007453 Uncharacterized conserved protein [Function unknown]; Region: COG1565 65393007454 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 65393007455 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 65393007456 putative RNA binding site [nucleotide binding]; other site 65393007457 16S rRNA methyltransferase B; Provisional; Region: PRK14901 65393007458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393007459 S-adenosylmethionine binding site [chemical binding]; other site 65393007460 tellurium resistance terB-like protein; Region: terB_like; cd07177 65393007461 metal binding site [ion binding]; metal-binding site 65393007462 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 65393007463 conserved cys residue [active] 65393007464 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 65393007465 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 65393007466 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 65393007467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393007468 active site 65393007469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393007470 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 65393007471 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 65393007472 antiporter inner membrane protein; Provisional; Region: PRK11670 65393007473 Domain of unknown function DUF59; Region: DUF59; cl00941 65393007474 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 65393007475 Walker A motif; other site 65393007476 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 65393007477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393007478 binding surface 65393007479 TPR motif; other site 65393007480 CHAT domain; Region: CHAT; cl02083 65393007481 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 65393007482 CHASE2 domain; Region: CHASE2; cl01732 65393007483 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 65393007484 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 65393007485 Uncharacterized conserved protein [Function unknown]; Region: COG5464 65393007486 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 65393007487 CHAT domain; Region: CHAT; cl02083 65393007488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393007489 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 65393007490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393007491 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 65393007492 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 65393007493 DNA gyrase subunit b; Provisional; Region: PTZ00109 65393007494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393007495 Mg2+ binding site [ion binding]; other site 65393007496 G-X-G motif; other site 65393007497 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 65393007498 anchoring element; other site 65393007499 dimer interface [polypeptide binding]; other site 65393007500 ATP binding site [chemical binding]; other site 65393007501 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 65393007502 active site 65393007503 metal binding site [ion binding]; metal-binding site 65393007504 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 65393007505 thioester formation/cholesterol transfer; other site 65393007506 protein-splicing catalytic site; other site 65393007507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 65393007508 non-specific DNA binding site [nucleotide binding]; other site 65393007509 salt bridge; other site 65393007510 sequence-specific DNA binding site [nucleotide binding]; other site 65393007511 DNA-directed RNA polymerase subunit A''; Provisional; Region: PRK14898 65393007512 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 65393007513 active site 65393007514 metal binding site [ion binding]; metal-binding site 65393007515 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 65393007516 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 65393007517 Helix-turn-helix domains; Region: HTH; cl00088 65393007518 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 65393007519 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393007520 putative active site [active] 65393007521 Domain of unknown function (DUF427); Region: DUF427; cl00998 65393007522 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 65393007523 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 65393007524 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 65393007525 Protein of unknown function (DUF541); Region: SIMPL; cl01077 65393007526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393007527 S-adenosylmethionine binding site [chemical binding]; other site 65393007528 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 65393007529 putative active site [active] 65393007530 catalytic site [active] 65393007531 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 65393007532 putative active site [active] 65393007533 catalytic site [active] 65393007534 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 65393007535 Protein of unknown function, DUF655; Region: DUF655; pfam04919 65393007536 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 65393007537 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 65393007538 Recombinase; Region: Recombinase; pfam07508 65393007539 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 65393007540 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 65393007541 dimer interface [polypeptide binding]; other site 65393007542 putative metal binding site [ion binding]; other site 65393007543 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 65393007544 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 65393007545 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393007546 metal binding site [ion binding]; metal-binding site 65393007547 active site 65393007548 I-site; other site 65393007549 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393007550 metal binding site [ion binding]; metal-binding site 65393007551 active site 65393007552 I-site; other site 65393007553 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 65393007554 putative hexamer interface [polypeptide binding]; other site 65393007555 putative hexagonal pore; other site 65393007556 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 65393007557 Hexamer interface [polypeptide binding]; other site 65393007558 Hexagonal pore residue; other site 65393007559 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007560 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007561 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007562 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007563 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007564 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 65393007565 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 65393007566 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 65393007567 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393007568 Protein of unknown function (DUF422); Region: DUF422; cl00991 65393007569 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393007570 active site 65393007571 Transposase; Region: HTH_Tnp_IS630; pfam01710 65393007572 Integrase core domain; Region: rve; cl01316 65393007573 Hantavirus glycoprotein G2; Region: Hanta_G2; pfam01561 65393007574 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 65393007575 conserved cys residue [active] 65393007576 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393007577 GAF domain; Region: GAF; cl00853 65393007578 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393007579 DNA binding residues [nucleotide binding] 65393007580 dimerization interface [polypeptide binding]; other site 65393007581 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 65393007582 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 65393007583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393007584 motif I; other site 65393007585 motif II; other site 65393007586 Cytochrome c; Region: Cytochrom_C; cl11414 65393007587 translation initiation factor IF-2; Validated; Region: infB; PRK05306 65393007588 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 65393007589 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 65393007590 putative active site [active] 65393007591 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 65393007592 putative active site [active] 65393007593 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 65393007594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393007595 dimer interface [polypeptide binding]; other site 65393007596 conserved gate region; other site 65393007597 putative PBP binding loops; other site 65393007598 ABC-ATPase subunit interface; other site 65393007599 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 65393007600 iron-sulfur cluster [ion binding]; other site 65393007601 [2Fe-2S] cluster binding site [ion binding]; other site 65393007602 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 65393007603 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 65393007604 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 65393007605 DNA repair protein RecN; Region: recN; TIGR00634 65393007606 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 65393007607 Walker A/P-loop; other site 65393007608 ATP binding site [chemical binding]; other site 65393007609 Q-loop/lid; other site 65393007610 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 65393007611 ABC transporter signature motif; other site 65393007612 Walker B; other site 65393007613 D-loop; other site 65393007614 H-loop/switch region; other site 65393007615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393007616 primosome assembly protein PriA; Validated; Region: PRK05580 65393007617 primosome assembly protein PriA; Validated; Region: PRK05580 65393007618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393007619 ATP binding site [chemical binding]; other site 65393007620 putative Mg++ binding site [ion binding]; other site 65393007621 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393007622 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 65393007623 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 65393007624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393007625 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393007626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393007627 DNA binding residues [nucleotide binding] 65393007628 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 65393007629 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 65393007630 active site 65393007631 metal binding site [ion binding]; metal-binding site 65393007632 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393007633 phosphopeptide binding site; other site 65393007634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393007635 metal binding site [ion binding]; metal-binding site 65393007636 active site 65393007637 I-site; other site 65393007638 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393007639 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393007640 phosphopeptide binding site; other site 65393007641 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393007642 metal binding site [ion binding]; metal-binding site 65393007643 active site 65393007644 I-site; other site 65393007645 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393007646 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393007647 phosphopeptide binding site; other site 65393007648 PAS domain S-box; Region: sensory_box; TIGR00229 65393007649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393007650 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393007651 metal binding site [ion binding]; metal-binding site 65393007652 active site 65393007653 I-site; other site 65393007654 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393007655 GAF domain; Region: GAF; cl00853 65393007656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393007657 Helix-turn-helix domains; Region: HTH; cl00088 65393007658 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393007659 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393007660 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 65393007661 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 65393007662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393007663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393007664 Walker A motif; other site 65393007665 ATP binding site [chemical binding]; other site 65393007666 Walker B motif; other site 65393007667 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 65393007668 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 65393007669 oligomer interface [polypeptide binding]; other site 65393007670 active site residues [active] 65393007671 trigger factor; Provisional; Region: tig; PRK01490 65393007672 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 65393007673 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 65393007674 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 65393007675 diiron binding motif [ion binding]; other site 65393007676 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 65393007677 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 65393007678 Walker A/P-loop; other site 65393007679 ATP binding site [chemical binding]; other site 65393007680 Q-loop/lid; other site 65393007681 ABC transporter signature motif; other site 65393007682 Walker B; other site 65393007683 D-loop; other site 65393007684 H-loop/switch region; other site 65393007685 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 65393007686 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 65393007687 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 65393007688 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 65393007689 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 65393007690 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393007691 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 65393007692 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 65393007693 D-pathway; other site 65393007694 Low-spin heme binding site [chemical binding]; other site 65393007695 Putative water exit pathway; other site 65393007696 Binuclear center (active site) [active] 65393007697 K-pathway; other site 65393007698 Putative proton exit pathway; other site 65393007699 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 65393007700 Subunit I/III interface [polypeptide binding]; other site 65393007701 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 65393007702 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 65393007703 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 65393007704 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393007705 Probable transposase; Region: OrfB_IS605; pfam01385 65393007706 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393007707 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 65393007708 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 65393007709 active site 65393007710 homodimer interface [polypeptide binding]; other site 65393007711 catalytic site [active] 65393007712 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 65393007713 proposed catalytic triad [active] 65393007714 conserved cys residue [active] 65393007715 Ferritin-like domain; Region: Ferritin; pfam00210 65393007716 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 65393007717 dinuclear metal binding motif [ion binding]; other site 65393007718 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 65393007719 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 65393007720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393007721 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393007722 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393007723 DNA binding residues [nucleotide binding] 65393007724 Response regulator receiver domain; Region: Response_reg; pfam00072 65393007725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393007726 active site 65393007727 phosphorylation site [posttranslational modification] 65393007728 intermolecular recognition site; other site 65393007729 dimerization interface [polypeptide binding]; other site 65393007730 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 65393007731 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 65393007732 BON domain; Region: BON; cl02771 65393007733 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 65393007734 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 65393007735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393007736 ATP binding site [chemical binding]; other site 65393007737 Mg2+ binding site [ion binding]; other site 65393007738 G-X-G motif; other site 65393007739 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 65393007740 ATP binding site [chemical binding]; other site 65393007741 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 65393007742 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 65393007743 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393007744 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 65393007745 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 65393007746 B12 binding site [chemical binding]; other site 65393007747 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 65393007748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15367 65393007749 FeS/SAM binding site; other site 65393007750 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 65393007751 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 65393007752 metal-binding site [ion binding] 65393007753 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393007754 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393007755 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393007756 phosphopeptide binding site; other site 65393007757 DNA polymerase III subunit delta'; Validated; Region: PRK07399 65393007758 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393007759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393007760 Radical SAM superfamily; Region: Radical_SAM; pfam04055 65393007761 FeS/SAM binding site; other site 65393007762 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 65393007763 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 65393007764 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 65393007765 transmembrane helices; other site 65393007766 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 65393007767 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 65393007768 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 65393007769 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 65393007770 Flavin Reductases; Region: FlaRed; cl00801 65393007771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 65393007772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 65393007773 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 65393007774 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 65393007775 CoA-binding site [chemical binding]; other site 65393007776 ATP-binding [chemical binding]; other site 65393007777 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393007778 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 65393007779 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393007780 AAA-like domain; Region: AAA_10; pfam12846 65393007781 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 65393007782 active site 65393007783 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393007784 Calx-beta domain; Region: Calx-beta; cl02522 65393007785 Calx-beta domain; Region: Calx-beta; cl02522 65393007786 FAD binding domain; Region: FAD_binding_4; pfam01565 65393007787 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 65393007788 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 65393007789 G1 box; other site 65393007790 GTP/Mg2+ binding site [chemical binding]; other site 65393007791 Switch I region; other site 65393007792 G2 box; other site 65393007793 Switch II region; other site 65393007794 G3 box; other site 65393007795 Domain of unknown function (DUF697); Region: DUF697; cl12064 65393007796 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 65393007797 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 65393007798 P-loop, Walker A motif; other site 65393007799 Base recognition motif; other site 65393007800 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 65393007801 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393007802 structural tetrad; other site 65393007803 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 65393007804 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 65393007805 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393007806 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393007807 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 65393007808 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 65393007809 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 65393007810 anti sigma factor interaction site; other site 65393007811 regulatory phosphorylation site [posttranslational modification]; other site 65393007812 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 65393007813 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 65393007814 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 65393007815 catalytic site [active] 65393007816 subunit interface [polypeptide binding]; other site 65393007817 Helix-turn-helix domains; Region: HTH; cl00088 65393007818 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007819 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393007820 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007821 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007822 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007823 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007824 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007825 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007826 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393007827 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 65393007828 acetyl-CoA synthetase; Provisional; Region: PRK00174 65393007829 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 65393007830 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393007831 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 65393007832 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 65393007833 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 65393007834 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 65393007835 putative active site [active] 65393007836 Restriction endonuclease; Region: Mrr_cat; cl00747 65393007837 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 65393007838 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 65393007839 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 65393007840 substrate binding site [chemical binding]; other site 65393007841 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 65393007842 substrate binding site [chemical binding]; other site 65393007843 ligand binding site [chemical binding]; other site 65393007844 YcfA-like protein; Region: YcfA; cl00752 65393007845 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 65393007846 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393007847 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 65393007848 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 65393007849 inhibitor binding site; inhibition site 65393007850 catalytic motif [active] 65393007851 Catalytic residue [active] 65393007852 Active site flap [active] 65393007853 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393007854 putative active site [active] 65393007855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393007856 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 65393007857 active site 65393007858 motif I; other site 65393007859 motif II; other site 65393007860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393007861 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 65393007862 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 65393007863 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 65393007864 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393007865 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 65393007866 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 65393007867 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 65393007868 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 65393007869 substrate binding pocket [chemical binding]; other site 65393007870 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 65393007871 B12 binding site [chemical binding]; other site 65393007872 cobalt ligand [ion binding]; other site 65393007873 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 65393007874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393007875 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393007876 Probable transposase; Region: OrfB_IS605; pfam01385 65393007877 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393007878 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 65393007879 Amidinotransferase; Region: Amidinotransf; cl12043 65393007880 Uncharacterized conserved protein [Function unknown]; Region: COG1915 65393007881 LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455 65393007882 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 65393007883 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 65393007884 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393007885 metal binding site [ion binding]; metal-binding site 65393007886 active site 65393007887 I-site; other site 65393007888 arginine-tRNA ligase; Region: PLN02286 65393007889 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 65393007890 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 65393007891 active site 65393007892 HIGH motif; other site 65393007893 KMSK motif region; other site 65393007894 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 65393007895 tRNA binding surface [nucleotide binding]; other site 65393007896 anticodon binding site; other site 65393007897 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 65393007898 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 65393007899 isoform II; Region: PAF-AH_p_II; pfam03403 65393007900 Membrane transport protein; Region: Mem_trans; cl09117 65393007901 aspartate kinase; Provisional; Region: PRK07431 65393007902 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 65393007903 putative nucleotide binding site [chemical binding]; other site 65393007904 putative catalytic residues [active] 65393007905 putative Mg ion binding site [ion binding]; other site 65393007906 putative aspartate binding site [chemical binding]; other site 65393007907 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 65393007908 putative allosteric regulatory site; other site 65393007909 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 65393007910 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 65393007911 putative allosteric regulatory site; other site 65393007912 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 65393007913 putative allosteric regulatory residue; other site 65393007914 TIR domain; Region: TIR; cl02060 65393007915 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393007916 structural tetrad; other site 65393007917 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393007918 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393007919 structural tetrad; other site 65393007920 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393007921 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 65393007922 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 65393007923 TPP-binding site [chemical binding]; other site 65393007924 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 65393007925 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393007926 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 65393007927 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 65393007928 NADP-binding site; other site 65393007929 homotetramer interface [polypeptide binding]; other site 65393007930 substrate binding site [chemical binding]; other site 65393007931 homodimer interface [polypeptide binding]; other site 65393007932 active site 65393007933 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393007934 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 65393007935 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 65393007936 Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310 65393007937 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 65393007938 Rab family. Rab GTPases form the largest family within the Ras superfamily. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. Rab GTPases are small, monomeric proteins that function as...; Region: Rab; cd00154 65393007939 Rab subfamily motif 1 (RabSF1); other site 65393007940 G1 box; other site 65393007941 GTP/Mg2+ binding site [chemical binding]; other site 65393007942 Rab subfamily motif 2 (RabSF2); other site 65393007943 Switch I region; other site 65393007944 G2 box; other site 65393007945 effector interaction site; other site 65393007946 GDI interaction site; other site 65393007947 Rab family motif 1 (RabF1); other site 65393007948 GEF interaction site [polypeptide binding]; other site 65393007949 Rab family motif 2 (RabF2); other site 65393007950 G3 box; other site 65393007951 Switch II region; other site 65393007952 Rab family motif 3 (RabF3); other site 65393007953 Rab family motif 4 (RabF4); other site 65393007954 Rab family motif 5 (RabF5); other site 65393007955 Rab subfamily motif 3 (RabSF3); other site 65393007956 G5 box; other site 65393007957 Rab subfamily motif 4 (RabSF4); other site 65393007958 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 65393007959 putative lipid kinase; Reviewed; Region: PRK13057 65393007960 CHAT domain; Region: CHAT; cl02083 65393007961 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393007962 phosphopeptide binding site; other site 65393007963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393007964 DNA binding residues [nucleotide binding] 65393007965 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393007966 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 65393007967 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 65393007968 putative ADP-binding pocket [chemical binding]; other site 65393007969 anthranilate synthase component I-like protein; Validated; Region: PRK05940 65393007970 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 65393007971 chorismate binding enzyme; Region: Chorismate_bind; cl10555 65393007972 YCF9; Region: Ycf9; cl09269 65393007973 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 65393007974 homopentamer interface [polypeptide binding]; other site 65393007975 active site 65393007976 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 65393007977 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 65393007978 putative catalytic cysteine [active] 65393007979 Bacterial SH3 domain; Region: SH3_3; cl02551 65393007980 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 65393007981 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 65393007982 active site 65393007983 metal binding site [ion binding]; metal-binding site 65393007984 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 65393007985 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 65393007986 Walker A/P-loop; other site 65393007987 ATP binding site [chemical binding]; other site 65393007988 Q-loop/lid; other site 65393007989 ABC transporter signature motif; other site 65393007990 Walker B; other site 65393007991 D-loop; other site 65393007992 H-loop/switch region; other site 65393007993 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 65393007994 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 65393007995 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 65393007996 dimer interface [polypeptide binding]; other site 65393007997 substrate binding site [chemical binding]; other site 65393007998 metal binding sites [ion binding]; metal-binding site 65393007999 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 65393008000 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 65393008001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393008002 dimer interface [polypeptide binding]; other site 65393008003 conserved gate region; other site 65393008004 putative PBP binding loops; other site 65393008005 ABC-ATPase subunit interface; other site 65393008006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393008007 Helix-turn-helix domains; Region: HTH; cl00088 65393008008 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 65393008009 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 65393008010 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 65393008011 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 65393008012 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 65393008013 putative NADP binding site [chemical binding]; other site 65393008014 putative substrate binding site [chemical binding]; other site 65393008015 active site 65393008016 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 65393008017 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 65393008018 putative active site [active] 65393008019 putative metal binding site [ion binding]; other site 65393008020 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393008021 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 65393008022 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 65393008023 P loop; other site 65393008024 Nucleotide binding site [chemical binding]; other site 65393008025 DTAP/Switch II; other site 65393008026 Switch I; other site 65393008027 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 65393008028 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 65393008029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 65393008030 substrate binding pocket [chemical binding]; other site 65393008031 membrane-bound complex binding site; other site 65393008032 hinge residues; other site 65393008033 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 65393008034 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393008035 FeS/SAM binding site; other site 65393008036 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 65393008037 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 65393008038 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 65393008039 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 65393008040 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 65393008041 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 65393008042 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393008043 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393008044 active site 65393008045 ATP binding site [chemical binding]; other site 65393008046 substrate binding site [chemical binding]; other site 65393008047 activation loop (A-loop); other site 65393008048 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 65393008049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393008050 Walker A motif; other site 65393008051 ATP binding site [chemical binding]; other site 65393008052 Walker B motif; other site 65393008053 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 65393008054 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 65393008055 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 65393008056 dimanganese center [ion binding]; other site 65393008057 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 65393008058 dimer interface [polypeptide binding]; other site 65393008059 RNA polymerase sigma factor; Provisional; Region: PRK12518 65393008060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393008061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393008062 DNA binding residues [nucleotide binding] 65393008063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393008064 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 65393008065 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 65393008066 DGQHR domain; Region: DGQHR; cl14002 65393008067 DGQHR domain; Region: DGQHR; cl14002 65393008068 glutathione synthetase; Provisional; Region: PRK05246 65393008069 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 65393008070 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393008071 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 65393008072 GSH binding site [chemical binding]; other site 65393008073 catalytic residues [active] 65393008074 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 65393008075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 65393008076 TRAM domain; Region: TRAM; cl01282 65393008077 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 65393008078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393008079 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 65393008080 active site 65393008081 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 65393008082 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 65393008083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 65393008084 Helix-turn-helix domains; Region: HTH; cl00088 65393008085 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 65393008086 putative dimerization interface [polypeptide binding]; other site 65393008087 cell division protein; Validated; Region: ftsH; CHL00176 65393008088 FtsH Extracellular; Region: FtsH_ext; pfam06480 65393008089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393008090 Walker A motif; other site 65393008091 ATP binding site [chemical binding]; other site 65393008092 Walker B motif; other site 65393008093 arginine finger; other site 65393008094 Peptidase family M41; Region: Peptidase_M41; pfam01434 65393008095 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 65393008096 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393008097 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 65393008098 Magnesium ion binding site [ion binding]; other site 65393008099 Membrane protein of unknown function; Region: DUF360; cl00850 65393008100 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 65393008101 Chromate transporter; Region: Chromate_transp; pfam02417 65393008102 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 65393008103 Chromate transporter; Region: Chromate_transp; pfam02417 65393008104 Protein of unknown function DUF89; Region: DUF89; cl15397 65393008105 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 65393008106 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 65393008107 Active site cavity [active] 65393008108 catalytic acid [active] 65393008109 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393008110 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008111 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008112 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008113 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008114 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008115 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008116 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 65393008117 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393008118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393008119 Probable transposase; Region: OrfB_IS605; pfam01385 65393008120 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393008121 Cupin domain; Region: Cupin_2; cl09118 65393008122 YGGT family; Region: YGGT; cl00508 65393008123 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 65393008124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393008125 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 65393008126 Low molecular weight phosphatase family; Region: LMWPc; cd00115 65393008127 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 65393008128 active site 65393008129 Membrane transport protein; Region: Mem_trans; cl09117 65393008130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393008131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 65393008132 dimerization interface [polypeptide binding]; other site 65393008133 putative DNA binding site [nucleotide binding]; other site 65393008134 putative Zn2+ binding site [ion binding]; other site 65393008135 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 65393008136 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 65393008137 putative active site [active] 65393008138 putative NTP binding site [chemical binding]; other site 65393008139 putative nucleic acid binding site [nucleotide binding]; other site 65393008140 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 65393008141 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 65393008142 active site 65393008143 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 65393008144 catalytic residues [active] 65393008145 NIL domain; Region: NIL; cl09633 65393008146 NADH-plastoquinone oxidoreductase subunit; Provisional; Region: PRK08348 65393008147 4Fe-4S binding domain; Region: Fer4; cl02805 65393008148 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393008149 Protein of unknown function, DUF488; Region: DUF488; cl01246 65393008150 lipoyl synthase; Provisional; Region: PRK05481 65393008151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15367 65393008152 FeS/SAM binding site; other site 65393008153 photosystem I P subunit (PSI-P); Region: PLN02777 65393008154 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 65393008155 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 65393008156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393008157 catalytic residue [active] 65393008158 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 65393008159 Fatty acid desaturase; Region: FA_desaturase; pfam00487 65393008160 Di-iron ligands [ion binding]; other site 65393008161 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 65393008162 homodecamer interface [polypeptide binding]; other site 65393008163 GTP cyclohydrolase I; Provisional; Region: PLN03044 65393008164 active site 65393008165 putative catalytic site residues [active] 65393008166 zinc binding site [ion binding]; other site 65393008167 GTP-CH-I/GFRP interaction surface; other site 65393008168 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 65393008169 classical (c) SDRs; Region: SDR_c; cd05233 65393008170 NAD(P) binding site [chemical binding]; other site 65393008171 active site 65393008172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393008173 Coenzyme A binding pocket [chemical binding]; other site 65393008174 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 65393008175 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393008176 DRTGG domain; Region: DRTGG; cl12147 65393008177 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 65393008178 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393008179 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393008180 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393008181 structural tetrad; other site 65393008182 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 65393008183 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 65393008184 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 65393008185 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 65393008186 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 65393008187 molybdopterin cofactor binding site; other site 65393008188 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 65393008189 molybdopterin cofactor binding site; other site 65393008190 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 65393008191 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393008192 FeS/SAM binding site; other site 65393008193 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 65393008194 Uncharacterized conserved protein [Function unknown]; Region: COG5464 65393008195 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 65393008196 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393008197 putative active site [active] 65393008198 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 65393008199 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 65393008200 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 65393008201 aromatic arch; other site 65393008202 DCoH dimer interaction site [polypeptide binding]; other site 65393008203 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 65393008204 DCoH tetramer interaction site [polypeptide binding]; other site 65393008205 substrate binding site [chemical binding]; other site 65393008206 Domain of unknown function (DUF477); Region: DUF477; cl01535 65393008207 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 65393008208 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 65393008209 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 65393008210 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 65393008211 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 65393008212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393008213 hypothetical protein; Validated; Region: PRK07411 65393008214 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 65393008215 ATP binding site [chemical binding]; other site 65393008216 substrate interface [chemical binding]; other site 65393008217 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 65393008218 active site residue [active] 65393008219 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 65393008220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393008221 putative substrate translocation pore; other site 65393008222 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 65393008223 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 65393008224 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393008225 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393008226 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 65393008227 rod shape-determining protein MreD; Region: MreD; cl01087 65393008228 rod shape-determining protein MreC; Region: MreC; pfam04085 65393008229 rod shape-determining protein MreB; Provisional; Region: PRK13927 65393008230 Cell division protein FtsA; Region: FtsA; cl11496 65393008231 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 65393008232 dimer interface [polypeptide binding]; other site 65393008233 ssDNA binding site [nucleotide binding]; other site 65393008234 tetramer (dimer of dimers) interface [polypeptide binding]; other site 65393008235 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393008236 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 65393008237 putative ADP-binding pocket [chemical binding]; other site 65393008238 Bacterial sugar transferase; Region: Bac_transf; cl00939 65393008239 GDP-mannose 4,6-dehydratase; Region: PLN02653 65393008240 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 65393008241 NADP-binding site; other site 65393008242 homotetramer interface [polypeptide binding]; other site 65393008243 substrate binding site [chemical binding]; other site 65393008244 homodimer interface [polypeptide binding]; other site 65393008245 active site 65393008246 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 65393008247 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 65393008248 NADP binding site [chemical binding]; other site 65393008249 active site 65393008250 putative substrate binding site [chemical binding]; other site 65393008251 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 65393008252 HflK protein; Region: hflK; TIGR01933 65393008253 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 65393008254 substrate binding pocket [chemical binding]; other site 65393008255 Ligand-gated ion channel; Region: Lig_chan; pfam00060 65393008256 Ion channel; Region: Ion_trans_2; cl11596 65393008257 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 65393008258 membrane-bound complex binding site; other site 65393008259 hinge residues; other site 65393008260 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393008261 putative active site [active] 65393008262 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 65393008263 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 65393008264 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 65393008265 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 65393008266 thioester formation/cholesterol transfer; other site 65393008267 protein-splicing catalytic site; other site 65393008268 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 65393008269 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 65393008270 substrate binding pocket [chemical binding]; other site 65393008271 membrane-bound complex binding site; other site 65393008272 hinge residues; other site 65393008273 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393008274 putative active site [active] 65393008275 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 65393008276 catalytic loop [active] 65393008277 iron binding site [ion binding]; other site 65393008278 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 65393008279 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 65393008280 active site 65393008281 catalytic residues [active] 65393008282 metal binding site [ion binding]; metal-binding site 65393008283 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 65393008284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393008285 S-adenosylmethionine binding site [chemical binding]; other site 65393008286 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393008287 putative active site [active] 65393008288 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393008289 putative active site [active] 65393008290 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 65393008291 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 65393008292 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 65393008293 putative acyl-acceptor binding pocket; other site 65393008294 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 65393008295 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 65393008296 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393008297 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 65393008298 Exoribonuclease R [Transcription]; Region: VacB; COG0557 65393008299 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 65393008300 RNB domain; Region: RNB; pfam00773 65393008301 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 65393008302 RNA binding site [nucleotide binding]; other site 65393008303 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 65393008304 oligomer interface [polypeptide binding]; other site 65393008305 active site residues [active] 65393008306 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 65393008307 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 65393008308 cobalamin binding residues [chemical binding]; other site 65393008309 putative BtuC binding residues; other site 65393008310 dimer interface [polypeptide binding]; other site 65393008311 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 65393008312 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 65393008313 catalytic site [active] 65393008314 G-X2-G-X-G-K; other site 65393008315 Domain of unknown function (DUF370); Region: DUF370; cl00898 65393008316 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 65393008317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393008318 S-adenosylmethionine binding site [chemical binding]; other site 65393008319 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 65393008320 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 65393008321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393008322 catalytic residue [active] 65393008323 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 65393008324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393008325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393008326 active site 65393008327 phosphorylation site [posttranslational modification] 65393008328 intermolecular recognition site; other site 65393008329 dimerization interface [polypeptide binding]; other site 65393008330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393008331 DNA binding site [nucleotide binding] 65393008332 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 65393008333 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 65393008334 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 65393008335 putative active site [active] 65393008336 catalytic triad [active] 65393008337 putative dimer interface [polypeptide binding]; other site 65393008338 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393008339 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 65393008340 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 65393008341 active site 65393008342 interdomain interaction site; other site 65393008343 putative metal-binding site [ion binding]; other site 65393008344 nucleotide binding site [chemical binding]; other site 65393008345 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 65393008346 domain I; other site 65393008347 phosphate binding site [ion binding]; other site 65393008348 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 65393008349 domain II; other site 65393008350 domain III; other site 65393008351 nucleotide binding site [chemical binding]; other site 65393008352 DNA binding groove [nucleotide binding] 65393008353 catalytic site [active] 65393008354 domain IV; other site 65393008355 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 65393008356 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 65393008357 active site 65393008358 homodimer interface [polypeptide binding]; other site 65393008359 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 65393008360 classical (c) SDRs; Region: SDR_c; cd05233 65393008361 NAD(P) binding site [chemical binding]; other site 65393008362 active site 65393008363 pyruvate kinase; Provisional; Region: PRK06354 65393008364 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 65393008365 domain interfaces; other site 65393008366 active site 65393008367 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 65393008368 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 65393008369 Domain of unknown function DUF20; Region: UPF0118; cl00465 65393008370 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 65393008371 iron-sulfur cluster [ion binding]; other site 65393008372 [2Fe-2S] cluster binding site [ion binding]; other site 65393008373 chaperone protein DnaJ; Provisional; Region: PRK14299 65393008374 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 65393008375 HSP70 interaction site [polypeptide binding]; other site 65393008376 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 65393008377 substrate binding site [polypeptide binding]; other site 65393008378 dimer interface [polypeptide binding]; other site 65393008379 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008380 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008381 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008382 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 65393008383 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 65393008384 FMN binding site [chemical binding]; other site 65393008385 active site 65393008386 catalytic residues [active] 65393008387 substrate binding site [chemical binding]; other site 65393008388 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 65393008389 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 65393008390 Walker A/P-loop; other site 65393008391 ATP binding site [chemical binding]; other site 65393008392 Q-loop/lid; other site 65393008393 ABC transporter signature motif; other site 65393008394 Walker B; other site 65393008395 D-loop; other site 65393008396 H-loop/switch region; other site 65393008397 sulfate transport protein; Provisional; Region: cysT; CHL00187 65393008398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393008399 dimer interface [polypeptide binding]; other site 65393008400 conserved gate region; other site 65393008401 putative PBP binding loops; other site 65393008402 ABC-ATPase subunit interface; other site 65393008403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393008404 dimer interface [polypeptide binding]; other site 65393008405 conserved gate region; other site 65393008406 putative PBP binding loops; other site 65393008407 ABC-ATPase subunit interface; other site 65393008408 NIL domain; Region: NIL; cl09633 65393008409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393008410 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 65393008411 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008412 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008413 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008414 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 65393008415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393008416 FeS/SAM binding site; other site 65393008417 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 65393008418 DNA polymerase III subunit delta; Validated; Region: PRK07452 65393008419 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 65393008420 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 65393008421 CHRD domain; Region: CHRD; cl06473 65393008422 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 65393008423 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 65393008424 [4Fe-4S] binding site [ion binding]; other site 65393008425 molybdopterin cofactor binding site; other site 65393008426 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 65393008427 molybdopterin cofactor binding site; other site 65393008428 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 65393008429 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 65393008430 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 65393008431 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 65393008432 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 65393008433 nudix motif; other site 65393008434 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 65393008435 trimer interface [polypeptide binding]; other site 65393008436 active site 65393008437 dimer interface [polypeptide binding]; other site 65393008438 competence damage-inducible protein A; Provisional; Region: PRK00549 65393008439 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 65393008440 putative MPT binding site; other site 65393008441 Competence-damaged protein; Region: CinA; cl00666 65393008442 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 65393008443 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 65393008444 Mg++ binding site [ion binding]; other site 65393008445 putative catalytic motif [active] 65393008446 substrate binding site [chemical binding]; other site 65393008447 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 65393008448 Probable Catalytic site; other site 65393008449 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 65393008450 Protein phosphatase 2C; Region: PP2C; pfam00481 65393008451 active site 65393008452 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 65393008453 S-adenosylmethionine synthetase; Validated; Region: PRK05250 65393008454 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 65393008455 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 65393008456 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 65393008457 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 65393008458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393008459 motif II; other site 65393008460 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 65393008461 GUN4-like; Region: GUN4; pfam05419 65393008462 Protein of unknown function DUF86; Region: DUF86; cl01031 65393008463 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393008464 active site 65393008465 NTP binding site [chemical binding]; other site 65393008466 metal binding triad [ion binding]; metal-binding site 65393008467 antibiotic binding site [chemical binding]; other site 65393008468 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 65393008469 30S ribosomal protein S1; Reviewed; Region: PRK07400 65393008470 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 65393008471 RNA binding site [nucleotide binding]; other site 65393008472 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 65393008473 RNA binding site [nucleotide binding]; other site 65393008474 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 65393008475 RNA binding site [nucleotide binding]; other site 65393008476 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 65393008477 ATP cone domain; Region: ATP-cone; pfam03477 65393008478 Photosystem II reaction centre T protein; Region: PsbT; cl11601 65393008479 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 65393008480 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 65393008481 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 65393008482 trimer interface [polypeptide binding]; other site 65393008483 active site 65393008484 UDP-GlcNAc binding site [chemical binding]; other site 65393008485 lipid binding site [chemical binding]; lipid-binding site 65393008486 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393008487 putative active site [active] 65393008488 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 65393008489 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 65393008490 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 65393008491 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 65393008492 catalytic loop [active] 65393008493 iron binding site [ion binding]; other site 65393008494 Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459 65393008495 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393008496 Ligand Binding Site [chemical binding]; other site 65393008497 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393008498 Ligand Binding Site [chemical binding]; other site 65393008499 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 65393008500 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393008501 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 65393008502 Walker A/P-loop; other site 65393008503 ATP binding site [chemical binding]; other site 65393008504 Q-loop/lid; other site 65393008505 ABC transporter signature motif; other site 65393008506 Walker B; other site 65393008507 D-loop; other site 65393008508 H-loop/switch region; other site 65393008509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 65393008510 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393008511 Acetokinase family; Region: Acetate_kinase; cl01029 65393008512 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 65393008513 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 65393008514 active site 65393008515 homodimer interface [polypeptide binding]; other site 65393008516 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 65393008517 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 65393008518 CpeS-like protein; Region: CpeS; pfam09367 65393008519 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 65393008520 PPIC-type PPIASE domain; Region: Rotamase; cl08278 65393008521 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 65393008522 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 65393008523 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393008524 ligand binding site [chemical binding]; other site 65393008525 flexible hinge region; other site 65393008526 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 65393008527 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 65393008528 putative active site [active] 65393008529 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393008530 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 65393008531 Walker A/P-loop; other site 65393008532 ATP binding site [chemical binding]; other site 65393008533 Q-loop/lid; other site 65393008534 ABC transporter signature motif; other site 65393008535 Walker B; other site 65393008536 D-loop; other site 65393008537 H-loop/switch region; other site 65393008538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393008539 flavoprotein, HI0933 family; Region: TIGR00275 65393008540 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 65393008541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393008542 TPR motif; other site 65393008543 binding surface 65393008544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393008545 sensory histidine kinase AtoS; Provisional; Region: PRK11360 65393008546 PAS domain S-box; Region: sensory_box; TIGR00229 65393008547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393008548 putative active site [active] 65393008549 heme pocket [chemical binding]; other site 65393008550 PAS domain S-box; Region: sensory_box; TIGR00229 65393008551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393008552 putative active site [active] 65393008553 heme pocket [chemical binding]; other site 65393008554 PAS domain S-box; Region: sensory_box; TIGR00229 65393008555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393008556 putative active site [active] 65393008557 heme pocket [chemical binding]; other site 65393008558 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393008559 GAF domain; Region: GAF; cl00853 65393008560 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393008561 metal binding site [ion binding]; metal-binding site 65393008562 active site 65393008563 I-site; other site 65393008564 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 65393008565 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 65393008566 Walker A/P-loop; other site 65393008567 ATP binding site [chemical binding]; other site 65393008568 Q-loop/lid; other site 65393008569 ABC transporter signature motif; other site 65393008570 Walker B; other site 65393008571 D-loop; other site 65393008572 H-loop/switch region; other site 65393008573 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 65393008574 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 65393008575 Walker A/P-loop; other site 65393008576 ATP binding site [chemical binding]; other site 65393008577 Q-loop/lid; other site 65393008578 ABC transporter signature motif; other site 65393008579 Walker B; other site 65393008580 D-loop; other site 65393008581 H-loop/switch region; other site 65393008582 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 65393008583 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 65393008584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393008585 dimer interface [polypeptide binding]; other site 65393008586 conserved gate region; other site 65393008587 putative PBP binding loops; other site 65393008588 ABC-ATPase subunit interface; other site 65393008589 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 65393008590 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 65393008591 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 65393008592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393008593 putative substrate translocation pore; other site 65393008594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393008595 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 65393008596 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 65393008597 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 65393008598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393008599 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 65393008600 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 65393008601 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 65393008602 substrate binding pocket (H-site) [chemical binding]; other site 65393008603 N-terminal domain interface [polypeptide binding]; other site 65393008604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393008605 S-adenosylmethionine binding site [chemical binding]; other site 65393008606 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 65393008607 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 65393008608 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 65393008609 active site 65393008610 zinc binding site [ion binding]; other site 65393008611 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393008612 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 65393008613 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 65393008614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393008615 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393008616 Probable transposase; Region: OrfB_IS605; pfam01385 65393008617 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393008618 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 65393008619 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 65393008620 nucleoside/Zn binding site; other site 65393008621 dimer interface [polypeptide binding]; other site 65393008622 catalytic motif [active] 65393008623 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 65393008624 GSH binding site [chemical binding]; other site 65393008625 catalytic residues [active] 65393008626 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 65393008627 active site 65393008628 dimer interface [polypeptide binding]; other site 65393008629 catalytic nucleophile [active] 65393008630 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393008631 putative active site [active] 65393008632 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 65393008633 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 65393008634 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 65393008635 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 65393008636 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 65393008637 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 65393008638 G1 box; other site 65393008639 putative GEF interaction site [polypeptide binding]; other site 65393008640 GTP/Mg2+ binding site [chemical binding]; other site 65393008641 Switch I region; other site 65393008642 G2 box; other site 65393008643 G3 box; other site 65393008644 Switch II region; other site 65393008645 G4 box; other site 65393008646 G5 box; other site 65393008647 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 65393008648 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 65393008649 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393008650 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 65393008651 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 65393008652 Probable Catalytic site; other site 65393008653 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 65393008654 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 65393008655 metal binding site [ion binding]; metal-binding site 65393008656 dimer interface [polypeptide binding]; other site 65393008657 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 65393008658 heterotetramer interface [polypeptide binding]; other site 65393008659 active site pocket [active] 65393008660 cleavage site 65393008661 Protein of unknown function (DUF433); Region: DUF433; cl01030 65393008662 Protein of unknown function (DUF497); Region: DUF497; cl01108 65393008663 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 65393008664 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 65393008665 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 65393008666 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 65393008667 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 65393008668 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 65393008669 GatB domain; Region: GatB_Yqey; cl11497 65393008670 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 65393008671 ligand binding site; other site 65393008672 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 65393008673 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 65393008674 B12 binding site [chemical binding]; other site 65393008675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393008676 FeS/SAM binding site; other site 65393008677 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 65393008678 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 65393008679 putative active site [active] 65393008680 oxyanion strand; other site 65393008681 catalytic triad [active] 65393008682 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 65393008683 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393008684 metal binding site [ion binding]; metal-binding site 65393008685 active site 65393008686 I-site; other site 65393008687 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393008688 putative active site [active] 65393008689 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 65393008690 Predicted kinase [General function prediction only]; Region: COG0645 65393008691 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 65393008692 ATP-binding site [chemical binding]; other site 65393008693 Gluconate-6-phosphate binding site [chemical binding]; other site 65393008694 FtsH Extracellular; Region: FtsH_ext; pfam06480 65393008695 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 65393008696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393008697 Walker A motif; other site 65393008698 ATP binding site [chemical binding]; other site 65393008699 Walker B motif; other site 65393008700 arginine finger; other site 65393008701 Peptidase family M41; Region: Peptidase_M41; pfam01434 65393008702 Predicted domain in sensory proteins (DUF2308); Region: DUF2308; cl01731 65393008703 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393008704 GAF domain; Region: GAF; cl00853 65393008705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393008706 dimer interface [polypeptide binding]; other site 65393008707 phosphorylation site [posttranslational modification] 65393008708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393008709 ATP binding site [chemical binding]; other site 65393008710 Mg2+ binding site [ion binding]; other site 65393008711 G-X-G motif; other site 65393008712 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 65393008713 PPIC-type PPIASE domain; Region: Rotamase; cl08278 65393008714 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393008715 ligand binding site [chemical binding]; other site 65393008716 flexible hinge region; other site 65393008717 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 65393008718 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cd02259 65393008719 putative active site [active] 65393008720 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393008721 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393008722 Walker A/P-loop; other site 65393008723 ATP binding site [chemical binding]; other site 65393008724 Q-loop/lid; other site 65393008725 ABC transporter signature motif; other site 65393008726 Walker B; other site 65393008727 D-loop; other site 65393008728 H-loop/switch region; other site 65393008729 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 65393008730 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 65393008731 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393008732 FeoA domain; Region: FeoA; cl00838 65393008733 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 65393008734 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393008735 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393008736 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 65393008737 dimer interface [polypeptide binding]; other site 65393008738 ADP-ribose binding site [chemical binding]; other site 65393008739 active site 65393008740 nudix motif; other site 65393008741 metal binding site [ion binding]; metal-binding site 65393008742 Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307 65393008743 Lumazine binding domain; Region: Lum_binding; pfam00677 65393008744 Lumazine binding domain; Region: Lum_binding; pfam00677 65393008745 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 65393008746 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 65393008747 active site 65393008748 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 65393008749 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 65393008750 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 65393008751 active site 65393008752 catalytic site [active] 65393008753 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 65393008754 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 65393008755 Cl- selectivity filter; other site 65393008756 Cl- binding residues [ion binding]; other site 65393008757 pore gating glutamate residue; other site 65393008758 dimer interface [polypeptide binding]; other site 65393008759 H+/Cl- coupling transport residue; other site 65393008760 FOG: CBS domain [General function prediction only]; Region: COG0517 65393008761 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 65393008762 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 65393008763 Ligand Binding Site [chemical binding]; other site 65393008764 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393008765 Ligand Binding Site [chemical binding]; other site 65393008766 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 65393008767 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 65393008768 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 65393008769 putative active site [active] 65393008770 putative metal binding site [ion binding]; other site 65393008771 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 65393008772 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393008773 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393008774 structural tetrad; other site 65393008775 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393008776 structural tetrad; other site 65393008777 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 65393008778 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905 65393008779 putative active site [active] 65393008780 Zn binding site [ion binding]; other site 65393008781 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 65393008782 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 65393008783 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 65393008784 Domain of unknown function DUF21; Region: DUF21; pfam01595 65393008785 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 65393008786 Transporter associated domain; Region: CorC_HlyC; cl08393 65393008787 Creatinine amidohydrolase; Region: Creatininase; cl00618 65393008788 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393008789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393008790 active site 65393008791 phosphorylation site [posttranslational modification] 65393008792 intermolecular recognition site; other site 65393008793 dimerization interface [polypeptide binding]; other site 65393008794 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393008795 DNA binding site [nucleotide binding] 65393008796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393008797 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 65393008798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393008799 dimer interface [polypeptide binding]; other site 65393008800 phosphorylation site [posttranslational modification] 65393008801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393008802 ATP binding site [chemical binding]; other site 65393008803 Mg2+ binding site [ion binding]; other site 65393008804 G-X-G motif; other site 65393008805 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 65393008806 PhoU domain; Region: PhoU; pfam01895 65393008807 PhoU domain; Region: PhoU; pfam01895 65393008808 S-layer homology domain; Region: SLH; pfam00395 65393008809 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 65393008810 S-layer homology domain; Region: SLH; pfam00395 65393008811 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 65393008812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393008813 dimer interface [polypeptide binding]; other site 65393008814 conserved gate region; other site 65393008815 putative PBP binding loops; other site 65393008816 ABC-ATPase subunit interface; other site 65393008817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393008818 dimer interface [polypeptide binding]; other site 65393008819 conserved gate region; other site 65393008820 ABC-ATPase subunit interface; other site 65393008821 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393008822 ligand binding site [chemical binding]; other site 65393008823 flexible hinge region; other site 65393008824 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 65393008825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393008826 Walker A motif; other site 65393008827 ATP binding site [chemical binding]; other site 65393008828 Walker B motif; other site 65393008829 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 65393008830 4Fe-4S binding domain; Region: Fer4_5; pfam12801 65393008831 4Fe-4S binding domain; Region: Fer4_5; pfam12801 65393008832 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 65393008833 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 65393008834 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 65393008835 purine monophosphate binding site [chemical binding]; other site 65393008836 dimer interface [polypeptide binding]; other site 65393008837 putative catalytic residues [active] 65393008838 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 65393008839 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 65393008840 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 65393008841 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 65393008842 active site 65393008843 catalytic residues [active] 65393008844 Phosphotransferase enzyme family; Region: APH; pfam01636 65393008845 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 65393008846 active site 65393008847 ATP binding site [chemical binding]; other site 65393008848 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 65393008849 substrate binding site [chemical binding]; other site 65393008850 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 65393008851 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 65393008852 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 65393008853 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 65393008854 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 65393008855 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 65393008856 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 65393008857 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 65393008858 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 65393008859 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 65393008860 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 65393008861 NAD(P) binding site [chemical binding]; other site 65393008862 putative active site [active] 65393008863 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 65393008864 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 65393008865 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393008866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393008867 Probable transposase; Region: OrfB_IS605; pfam01385 65393008868 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393008869 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 65393008870 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 65393008871 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 65393008872 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 65393008873 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 65393008874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 65393008875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393008876 ABC-ATPase subunit interface; other site 65393008877 putative PBP binding loops; other site 65393008878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 65393008879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 65393008880 non-specific DNA binding site [nucleotide binding]; other site 65393008881 salt bridge; other site 65393008882 sequence-specific DNA binding site [nucleotide binding]; other site 65393008883 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008884 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393008885 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008886 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008887 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008888 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008889 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008890 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393008891 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 65393008892 substrate binding site [chemical binding]; other site 65393008893 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 65393008894 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 65393008895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393008896 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 65393008897 substrate binding site; other site 65393008898 dimer interface; other site 65393008899 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 65393008900 heme binding pocket [chemical binding]; other site 65393008901 heme ligand [chemical binding]; other site 65393008902 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393008903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393008904 active site 65393008905 phosphorylation site [posttranslational modification] 65393008906 intermolecular recognition site; other site 65393008907 dimerization interface [polypeptide binding]; other site 65393008908 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393008909 DNA binding site [nucleotide binding] 65393008910 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 65393008911 catalytic triad [active] 65393008912 cobyric acid synthase; Provisional; Region: PRK00784 65393008913 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393008914 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393008915 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 65393008916 catalytic triad [active] 65393008917 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 65393008918 catalytic loop [active] 65393008919 iron binding site [ion binding]; other site 65393008920 DinB superfamily; Region: DinB_2; cl00986 65393008921 Uncharacterized conserved protein [Function unknown]; Region: COG1432 65393008922 LabA_like proteins; Region: LabA; cd10911 65393008923 putative metal binding site [ion binding]; other site 65393008924 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 65393008925 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 65393008926 active site residue [active] 65393008927 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 65393008928 active site residue [active] 65393008929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 65393008930 Response regulator receiver domain; Region: Response_reg; pfam00072 65393008931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393008932 active site 65393008933 phosphorylation site [posttranslational modification] 65393008934 intermolecular recognition site; other site 65393008935 dimerization interface [polypeptide binding]; other site 65393008936 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 65393008937 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 65393008938 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 65393008939 anti sigma factor interaction site; other site 65393008940 regulatory phosphorylation site [posttranslational modification]; other site 65393008941 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 65393008942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393008943 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 65393008944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393008945 NAD(P) binding site [chemical binding]; other site 65393008946 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 65393008947 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 65393008948 active site 65393008949 dimer interface [polypeptide binding]; other site 65393008950 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 65393008951 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 65393008952 active site 65393008953 FMN binding site [chemical binding]; other site 65393008954 substrate binding site [chemical binding]; other site 65393008955 3Fe-4S cluster binding site [ion binding]; other site 65393008956 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 65393008957 domain interface; other site 65393008958 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393008959 putative active site [active] 65393008960 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 65393008961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393008962 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393008963 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 65393008964 dimer interface [polypeptide binding]; other site 65393008965 motif 1; other site 65393008966 active site 65393008967 motif 2; other site 65393008968 motif 3; other site 65393008969 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 65393008970 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 65393008971 putative active site [active] 65393008972 Zn binding site [ion binding]; other site 65393008973 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 65393008974 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393008975 Cytochrome c; Region: Cytochrom_C; cl11414 65393008976 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 65393008977 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 65393008978 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 65393008979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393008980 dimerization interface [polypeptide binding]; other site 65393008981 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 65393008982 Protein of unknown function (DUF760); Region: DUF760; pfam05542 65393008983 CemA family; Region: CemA; cl03855 65393008984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393008985 DNA binding residues [nucleotide binding] 65393008986 dimerization interface [polypeptide binding]; other site 65393008987 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393008988 GAF domain; Region: GAF; cl00853 65393008989 Phytochrome region; Region: PHY; pfam00360 65393008990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393008991 metal binding site [ion binding]; metal-binding site 65393008992 active site 65393008993 I-site; other site 65393008994 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393008995 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393008996 GAF domain; Region: GAF; cl00853 65393008997 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393008998 metal binding site [ion binding]; metal-binding site 65393008999 active site 65393009000 I-site; other site 65393009001 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 65393009002 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 65393009003 putative catalytic cysteine [active] 65393009004 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 65393009005 putative active site [active] 65393009006 metal binding site [ion binding]; metal-binding site 65393009007 isocitrate dehydrogenase; Validated; Region: PRK06451 65393009008 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 65393009009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393009010 S-adenosylmethionine binding site [chemical binding]; other site 65393009011 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 65393009012 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 65393009013 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 65393009014 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 65393009015 active site 65393009016 ATP binding site [chemical binding]; other site 65393009017 HupF/HypC family; Region: HupF_HypC; cl00394 65393009018 Acylphosphatase; Region: Acylphosphatase; cl00551 65393009019 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 65393009020 HypF finger; Region: zf-HYPF; pfam07503 65393009021 HypF finger; Region: zf-HYPF; pfam07503 65393009022 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 65393009023 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 65393009024 dimerization interface [polypeptide binding]; other site 65393009025 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 65393009026 ATP binding site [chemical binding]; other site 65393009027 UbiA prenyltransferase family; Region: UbiA; cl00337 65393009028 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 65393009029 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 65393009030 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 65393009031 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393009032 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 65393009033 nucleophilic elbow; other site 65393009034 catalytic triad; other site 65393009035 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 65393009036 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 65393009037 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 65393009038 active site 65393009039 catalytic site [active] 65393009040 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 65393009041 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393009042 putative acyl-acceptor binding pocket; other site 65393009043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393009044 putative substrate translocation pore; other site 65393009045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 65393009046 serine O-acetyltransferase; Region: cysE; TIGR01172 65393009047 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 65393009048 trimer interface [polypeptide binding]; other site 65393009049 active site 65393009050 substrate binding site [chemical binding]; other site 65393009051 CoA binding site [chemical binding]; other site 65393009052 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 65393009053 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 65393009054 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 65393009055 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 65393009056 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 65393009057 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 65393009058 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 65393009059 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 65393009060 putative translocon binding site; other site 65393009061 protein-rRNA interface [nucleotide binding]; other site 65393009062 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 65393009063 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 65393009064 G-X-X-G motif; other site 65393009065 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 65393009066 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 65393009067 23S rRNA interface [nucleotide binding]; other site 65393009068 5S rRNA interface [nucleotide binding]; other site 65393009069 putative antibiotic binding site [chemical binding]; other site 65393009070 L25 interface [polypeptide binding]; other site 65393009071 L27 interface [polypeptide binding]; other site 65393009072 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 65393009073 putative translocon interaction site; other site 65393009074 23S rRNA interface [nucleotide binding]; other site 65393009075 signal recognition particle (SRP54) interaction site; other site 65393009076 L23 interface [polypeptide binding]; other site 65393009077 trigger factor interaction site; other site 65393009078 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 65393009079 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 65393009080 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 65393009081 KOW motif; Region: KOW; cl00354 65393009082 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 65393009083 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 65393009084 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 65393009085 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 65393009086 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 65393009087 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 65393009088 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 65393009089 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 65393009090 23S rRNA interface [nucleotide binding]; other site 65393009091 L21e interface [polypeptide binding]; other site 65393009092 5S rRNA interface [nucleotide binding]; other site 65393009093 L27 interface [polypeptide binding]; other site 65393009094 L5 interface [polypeptide binding]; other site 65393009095 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 65393009096 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 65393009097 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 65393009098 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 65393009099 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 65393009100 SecY translocase; Region: SecY; pfam00344 65393009101 adenylate kinase; Provisional; Region: adk; PRK02496 65393009102 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 65393009103 AMP-binding site [chemical binding]; other site 65393009104 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 65393009105 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 65393009106 rRNA binding site [nucleotide binding]; other site 65393009107 predicted 30S ribosome binding site; other site 65393009108 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 65393009109 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 65393009110 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 65393009111 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 65393009112 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 65393009113 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 65393009114 alphaNTD homodimer interface [polypeptide binding]; other site 65393009115 alphaNTD - beta interaction site [polypeptide binding]; other site 65393009116 alphaNTD - beta' interaction site [polypeptide binding]; other site 65393009117 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 65393009118 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 65393009119 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 65393009120 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 65393009121 dimerization interface 3.5A [polypeptide binding]; other site 65393009122 active site 65393009123 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 65393009124 23S rRNA interface [nucleotide binding]; other site 65393009125 L3 interface [polypeptide binding]; other site 65393009126 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 65393009127 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 65393009128 peptide chain release factor 1; Validated; Region: prfA; PRK00591 65393009129 RF-1 domain; Region: RF-1; cl02875 65393009130 RF-1 domain; Region: RF-1; cl02875 65393009131 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393009132 putative active site [active] 65393009133 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393009134 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 65393009135 ligand binding site [chemical binding]; other site 65393009136 flexible hinge region; other site 65393009137 Helix-turn-helix domains; Region: HTH; cl00088 65393009138 Electron transfer DM13; Region: DM13; cl02735 65393009139 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 65393009140 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 65393009141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393009142 ATP binding site [chemical binding]; other site 65393009143 putative Mg++ binding site [ion binding]; other site 65393009144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393009145 nucleotide binding region [chemical binding]; other site 65393009146 ATP-binding site [chemical binding]; other site 65393009147 TRCF domain; Region: TRCF; cl04088 65393009148 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393009149 adenylosuccinate lyase; Provisional; Region: PRK07380 65393009150 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 65393009151 tetramer interface [polypeptide binding]; other site 65393009152 active site 65393009153 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 65393009154 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 65393009155 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393009156 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393009157 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 65393009158 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 65393009159 Domain of unknown function (DUF309); Region: DUF309; cl00667 65393009160 OstA-like protein; Region: OstA; cl00844 65393009161 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 65393009162 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 65393009163 Walker A/P-loop; other site 65393009164 ATP binding site [chemical binding]; other site 65393009165 Q-loop/lid; other site 65393009166 ABC transporter signature motif; other site 65393009167 Walker B; other site 65393009168 D-loop; other site 65393009169 H-loop/switch region; other site 65393009170 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 65393009171 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 65393009172 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 65393009173 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 65393009174 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 65393009175 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 65393009176 homodimer interface [polypeptide binding]; other site 65393009177 substrate-cofactor binding pocket; other site 65393009178 Aminotransferase class IV; Region: Aminotran_4; pfam01063 65393009179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393009180 catalytic residue [active] 65393009181 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393009182 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 65393009183 substrate binding pocket [chemical binding]; other site 65393009184 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393009185 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 65393009186 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 65393009187 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 65393009188 NAD(P) binding site [chemical binding]; other site 65393009189 catalytic residues [active] 65393009190 Protein of unknown function DUF104; Region: DUF104; cl11530 65393009191 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G_bact; cd04170 65393009192 elongation factor G; Reviewed; Region: PRK12740 65393009193 G1 box; other site 65393009194 putative GEF interaction site [polypeptide binding]; other site 65393009195 GTP/Mg2+ binding site [chemical binding]; other site 65393009196 Switch I region; other site 65393009197 G2 box; other site 65393009198 G3 box; other site 65393009199 Switch II region; other site 65393009200 G4 box; other site 65393009201 G5 box; other site 65393009202 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 65393009203 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 65393009204 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 65393009205 GAF domain; Region: GAF; cl00853 65393009206 Response regulator receiver domain; Region: Response_reg; pfam00072 65393009207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393009208 active site 65393009209 phosphorylation site [posttranslational modification] 65393009210 intermolecular recognition site; other site 65393009211 dimerization interface [polypeptide binding]; other site 65393009212 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 65393009213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393009214 PAS fold; Region: PAS_3; pfam08447 65393009215 putative active site [active] 65393009216 heme pocket [chemical binding]; other site 65393009217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 65393009218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393009219 dimer interface [polypeptide binding]; other site 65393009220 phosphorylation site [posttranslational modification] 65393009221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393009222 ATP binding site [chemical binding]; other site 65393009223 Mg2+ binding site [ion binding]; other site 65393009224 G-X-G motif; other site 65393009225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393009226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393009227 dimer interface [polypeptide binding]; other site 65393009228 phosphorylation site [posttranslational modification] 65393009229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393009230 ATP binding site [chemical binding]; other site 65393009231 Mg2+ binding site [ion binding]; other site 65393009232 G-X-G motif; other site 65393009233 Response regulator receiver domain; Region: Response_reg; pfam00072 65393009234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393009235 active site 65393009236 phosphorylation site [posttranslational modification] 65393009237 intermolecular recognition site; other site 65393009238 dimerization interface [polypeptide binding]; other site 65393009239 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 65393009240 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393009241 dimerization interface [polypeptide binding]; other site 65393009242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393009243 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 65393009244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393009245 dimerization interface [polypeptide binding]; other site 65393009246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393009247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393009248 dimerization interface [polypeptide binding]; other site 65393009249 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393009250 dimerization interface [polypeptide binding]; other site 65393009251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393009252 dimerization interface [polypeptide binding]; other site 65393009253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393009254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393009255 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393009256 GAF domain; Region: GAF; cl00853 65393009257 Ezrin/radixin/moesin family; Region: ERM; pfam00769 65393009258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 65393009259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393009260 ATP binding site [chemical binding]; other site 65393009261 Mg2+ binding site [ion binding]; other site 65393009262 G-X-G motif; other site 65393009263 Response regulator receiver domain; Region: Response_reg; pfam00072 65393009264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393009265 active site 65393009266 phosphorylation site [posttranslational modification] 65393009267 intermolecular recognition site; other site 65393009268 dimerization interface [polypeptide binding]; other site 65393009269 Response regulator receiver domain; Region: Response_reg; pfam00072 65393009270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393009271 active site 65393009272 phosphorylation site [posttranslational modification] 65393009273 intermolecular recognition site; other site 65393009274 dimerization interface [polypeptide binding]; other site 65393009275 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 65393009276 active site 65393009277 Zn binding site [ion binding]; other site 65393009278 FOG: WD40-like repeat [Function unknown]; Region: COG1520 65393009279 Protein of unknown function (DUF990); Region: DUF990; cl01496 65393009280 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 65393009281 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 65393009282 DHH family; Region: DHH; pfam01368 65393009283 DHHA1 domain; Region: DHHA1; pfam02272 65393009284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393009285 active site 65393009286 phosphorylation site [posttranslational modification] 65393009287 intermolecular recognition site; other site 65393009288 dimerization interface [polypeptide binding]; other site 65393009289 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 65393009290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393009291 FeS/SAM binding site; other site 65393009292 sucrose synthase; Region: sucr_synth; TIGR02470 65393009293 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 65393009294 putative ADP-binding pocket [chemical binding]; other site 65393009295 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 65393009296 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 65393009297 active site 65393009298 dimer interface [polypeptide binding]; other site 65393009299 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 65393009300 dimer interface [polypeptide binding]; other site 65393009301 active site 65393009302 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 65393009303 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 65393009304 NAD binding site [chemical binding]; other site 65393009305 dimer interface [polypeptide binding]; other site 65393009306 substrate binding site [chemical binding]; other site 65393009307 tetramer (dimer of dimers) interface [polypeptide binding]; other site 65393009308 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393009309 Ligand Binding Site [chemical binding]; other site 65393009310 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 65393009311 putative phosphoketolase; Provisional; Region: PRK05261 65393009312 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 65393009313 TPP-binding site; other site 65393009314 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 65393009315 XFP C-terminal domain; Region: XFP_C; pfam09363 65393009316 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 65393009317 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 65393009318 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 65393009319 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 65393009320 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 65393009321 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 65393009322 active site 65393009323 catalytic site [active] 65393009324 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 65393009325 putative catalytic site [active] 65393009326 putative metal binding site [ion binding]; other site 65393009327 putative phosphate binding site [ion binding]; other site 65393009328 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 65393009329 putative catalytic site [active] 65393009330 putative phosphate binding site [ion binding]; other site 65393009331 putative metal binding site [ion binding]; other site 65393009332 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 65393009333 putative dimer interface [polypeptide binding]; other site 65393009334 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 65393009335 DoxX; Region: DoxX; cl00976 65393009336 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 65393009337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393009338 S-adenosylmethionine binding site [chemical binding]; other site 65393009339 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 65393009340 catalytic loop [active] 65393009341 iron binding site [ion binding]; other site 65393009342 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 65393009343 Domain of unknown function DUF20; Region: UPF0118; cl00465 65393009344 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393009345 Ligand Binding Site [chemical binding]; other site 65393009346 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 65393009347 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 65393009348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393009349 catalytic residue [active] 65393009350 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 65393009351 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 65393009352 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 65393009353 putative active site [active] 65393009354 catalytic site [active] 65393009355 putative substrate binding site [chemical binding]; other site 65393009356 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 65393009357 active site 65393009358 ribulose/triose binding site [chemical binding]; other site 65393009359 phosphate binding site [ion binding]; other site 65393009360 substrate (anthranilate) binding pocket [chemical binding]; other site 65393009361 product (indole) binding pocket [chemical binding]; other site 65393009362 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 65393009363 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 65393009364 homodimer interface [polypeptide binding]; other site 65393009365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393009366 catalytic residue [active] 65393009367 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 65393009368 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393009369 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393009370 ligand binding site [chemical binding]; other site 65393009371 flexible hinge region; other site 65393009372 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 65393009373 SNF2 Helicase protein; Region: DUF3670; pfam12419 65393009374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393009375 ATP binding site [chemical binding]; other site 65393009376 putative Mg++ binding site [ion binding]; other site 65393009377 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393009378 nucleotide binding region [chemical binding]; other site 65393009379 ATP-binding site [chemical binding]; other site 65393009380 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393009381 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393009382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393009383 binding surface 65393009384 TPR motif; other site 65393009385 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 65393009386 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 65393009387 Catalytic site [active] 65393009388 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 65393009389 AIR carboxylase; Region: AIRC; cl00310 65393009390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393009391 S-adenosylmethionine binding site [chemical binding]; other site 65393009392 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 65393009393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393009394 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 65393009395 catalytic residues [active] 65393009396 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 65393009397 putative active site [active] 65393009398 Double zinc ribbon; Region: DZR; pfam12773 65393009399 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393009400 phosphopeptide binding site; other site 65393009401 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 65393009402 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 65393009403 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 65393009404 active site 65393009405 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 65393009406 Cobalt transport protein component CbiN; Region: CbiN; cl00842 65393009407 Cobalt transport protein; Region: CbiQ; cl00463 65393009408 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 65393009409 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 65393009410 Walker A/P-loop; other site 65393009411 ATP binding site [chemical binding]; other site 65393009412 Q-loop/lid; other site 65393009413 ABC transporter signature motif; other site 65393009414 Walker B; other site 65393009415 D-loop; other site 65393009416 H-loop/switch region; other site 65393009417 tocopherol O-methyltransferase; Region: PLN02244 65393009418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393009419 S-adenosylmethionine binding site [chemical binding]; other site 65393009420 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 65393009421 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393009422 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 65393009423 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393009424 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 65393009425 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 65393009426 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 65393009427 Uncharacterized conserved protein [Function unknown]; Region: COG5361 65393009428 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 65393009429 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 65393009430 Sulfatase; Region: Sulfatase; cl10460 65393009431 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 65393009432 transcriptional regulator EutR; Provisional; Region: PRK10130 65393009433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 65393009434 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 65393009435 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 65393009436 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 65393009437 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 65393009438 dimer interface [polypeptide binding]; other site 65393009439 active site 65393009440 aspartate-rich active site metal binding site; other site 65393009441 allosteric magnesium binding site [ion binding]; other site 65393009442 Schiff base residues; other site 65393009443 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 65393009444 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 65393009445 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 65393009446 active site 65393009447 metal binding site [ion binding]; metal-binding site 65393009448 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 65393009449 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393009450 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 65393009451 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 65393009452 homodecamer interface [polypeptide binding]; other site 65393009453 GTP cyclohydrolase I; Provisional; Region: PLN03044 65393009454 active site 65393009455 putative catalytic site residues [active] 65393009456 zinc binding site [ion binding]; other site 65393009457 GTP-CH-I/GFRP interaction surface; other site 65393009458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393009459 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393009460 ATP binding site [chemical binding]; other site 65393009461 putative Mg++ binding site [ion binding]; other site 65393009462 Protein of unknown function (DUF433); Region: DUF433; cl01030 65393009463 Integrase core domain; Region: rve; cl01316 65393009464 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393009465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393009466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393009467 binding surface 65393009468 TPR motif; other site 65393009469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393009470 binding surface 65393009471 TPR motif; other site 65393009472 DNA topoisomerase I; Validated; Region: PRK05582 65393009473 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 65393009474 active site 65393009475 interdomain interaction site; other site 65393009476 putative metal-binding site [ion binding]; other site 65393009477 nucleotide binding site [chemical binding]; other site 65393009478 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 65393009479 domain I; other site 65393009480 phosphate binding site [ion binding]; other site 65393009481 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 65393009482 domain II; other site 65393009483 domain III; other site 65393009484 nucleotide binding site [chemical binding]; other site 65393009485 DNA binding groove [nucleotide binding] 65393009486 catalytic site [active] 65393009487 domain IV; other site 65393009488 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 65393009489 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 65393009490 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 65393009491 substrate binding site [chemical binding]; other site 65393009492 dimer interface [polypeptide binding]; other site 65393009493 ATP binding site [chemical binding]; other site 65393009494 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 65393009495 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 65393009496 active site 65393009497 metal binding site [ion binding]; metal-binding site 65393009498 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 65393009499 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 65393009500 ligand binding site [chemical binding]; other site 65393009501 hypothetical protein; Provisional; Region: PRK11281 65393009502 DinB superfamily; Region: DinB_2; cl00986 65393009503 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393009504 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 65393009505 Walker A motif; other site 65393009506 ATP binding site [chemical binding]; other site 65393009507 Walker B motif; other site 65393009508 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393009509 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 65393009510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393009511 AAA-like domain; Region: AAA_10; pfam12846 65393009512 Protein of unknown function (DUF433); Region: DUF433; cl01030 65393009513 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 65393009514 Protein of unknown function DUF86; Region: DUF86; cl01031 65393009515 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393009516 active site 65393009517 NTP binding site [chemical binding]; other site 65393009518 metal binding triad [ion binding]; metal-binding site 65393009519 antibiotic binding site [chemical binding]; other site 65393009520 HsdM N-terminal domain; Region: HsdM_N; pfam12161 65393009521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393009522 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393009523 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393009524 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393009525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393009526 ATP binding site [chemical binding]; other site 65393009527 putative Mg++ binding site [ion binding]; other site 65393009528 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 65393009529 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393009530 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 65393009531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 65393009532 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 65393009533 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 65393009534 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393009535 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393009536 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 65393009537 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 65393009538 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 65393009539 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393009540 catalytic residue [active] 65393009541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393009542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393009543 active site 65393009544 phosphorylation site [posttranslational modification] 65393009545 intermolecular recognition site; other site 65393009546 dimerization interface [polypeptide binding]; other site 65393009547 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393009548 DNA binding site [nucleotide binding] 65393009549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393009550 dimer interface [polypeptide binding]; other site 65393009551 phosphorylation site [posttranslational modification] 65393009552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393009553 ATP binding site [chemical binding]; other site 65393009554 Mg2+ binding site [ion binding]; other site 65393009555 G-X-G motif; other site 65393009556 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 65393009557 Domain of unknown function DUF20; Region: UPF0118; cl00465 65393009558 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 65393009559 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 65393009560 trehalose synthase; Region: treS_nterm; TIGR02456 65393009561 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 65393009562 active site 65393009563 catalytic site [active] 65393009564 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 65393009565 glucose-1-dehydrogenase; Provisional; Region: PRK08936 65393009566 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 65393009567 NAD binding site [chemical binding]; other site 65393009568 homodimer interface [polypeptide binding]; other site 65393009569 active site 65393009570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393009571 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 65393009572 active site 65393009573 catalytic residues [active] 65393009574 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 65393009575 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 65393009576 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 65393009577 putative C-terminal domain interface [polypeptide binding]; other site 65393009578 putative GSH binding site (G-site) [chemical binding]; other site 65393009579 putative dimer interface [polypeptide binding]; other site 65393009580 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 65393009581 putative N-terminal domain interface [polypeptide binding]; other site 65393009582 putative dimer interface [polypeptide binding]; other site 65393009583 putative substrate binding pocket (H-site) [chemical binding]; other site 65393009584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393009585 Helix-turn-helix domains; Region: HTH; cl00088 65393009586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393009587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393009588 binding surface 65393009589 TPR motif; other site 65393009590 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 65393009591 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 65393009592 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 65393009593 cytochrome b subunit interaction site [polypeptide binding]; other site 65393009594 [2Fe-2S] cluster binding site [ion binding]; other site 65393009595 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 65393009596 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 65393009597 metal binding site 2 [ion binding]; metal-binding site 65393009598 putative DNA binding helix; other site 65393009599 metal binding site 1 [ion binding]; metal-binding site 65393009600 dimer interface [polypeptide binding]; other site 65393009601 structural Zn2+ binding site [ion binding]; other site 65393009602 Fe-S metabolism associated domain; Region: SufE; cl00951 65393009603 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 65393009604 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 65393009605 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 65393009606 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393009607 active site 65393009608 ATP binding site [chemical binding]; other site 65393009609 substrate binding site [chemical binding]; other site 65393009610 activation loop (A-loop); other site 65393009611 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393009612 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 65393009613 dimerization interface [polypeptide binding]; other site 65393009614 active site 65393009615 metal binding site [ion binding]; metal-binding site 65393009616 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 65393009617 dsRNA binding site [nucleotide binding]; other site 65393009618 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 65393009619 patatin-related protein; Region: TIGR03607 65393009620 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 65393009621 nucleophile elbow; other site 65393009622 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 65393009623 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 65393009624 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 65393009625 tandem repeat interface [polypeptide binding]; other site 65393009626 oligomer interface [polypeptide binding]; other site 65393009627 active site residues [active] 65393009628 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 65393009629 tandem repeat interface [polypeptide binding]; other site 65393009630 oligomer interface [polypeptide binding]; other site 65393009631 active site residues [active] 65393009632 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 65393009633 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393009634 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 65393009635 phosphoenolpyruvate synthase; Validated; Region: PRK06464 65393009636 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 65393009637 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 65393009638 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 65393009639 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393009640 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 65393009641 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393009642 Walker A/P-loop; other site 65393009643 ATP binding site [chemical binding]; other site 65393009644 Q-loop/lid; other site 65393009645 ABC transporter signature motif; other site 65393009646 Walker B; other site 65393009647 D-loop; other site 65393009648 H-loop/switch region; other site 65393009649 Response regulator receiver domain; Region: Response_reg; pfam00072 65393009650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393009651 active site 65393009652 phosphorylation site [posttranslational modification] 65393009653 intermolecular recognition site; other site 65393009654 dimerization interface [polypeptide binding]; other site 65393009655 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 65393009656 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 65393009657 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 65393009658 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 65393009659 ligand binding site [chemical binding]; other site 65393009660 flexible hinge region; other site 65393009661 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 65393009662 non-specific DNA interactions [nucleotide binding]; other site 65393009663 DNA binding site [nucleotide binding] 65393009664 sequence specific DNA binding site [nucleotide binding]; other site 65393009665 putative cAMP binding site [chemical binding]; other site 65393009666 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 65393009667 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 65393009668 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 65393009669 substrate binding site [chemical binding]; other site 65393009670 catalytic Zn binding site [ion binding]; other site 65393009671 NAD binding site [chemical binding]; other site 65393009672 structural Zn binding site [ion binding]; other site 65393009673 dimer interface [polypeptide binding]; other site 65393009674 DoxX; Region: DoxX; cl00976 65393009675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393009676 Probable transposase; Region: OrfB_IS605; pfam01385 65393009677 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393009678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393009679 Coenzyme A binding pocket [chemical binding]; other site 65393009680 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393009681 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 65393009682 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 65393009683 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 65393009684 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 65393009685 intersubunit interface [polypeptide binding]; other site 65393009686 muropeptide transporter; Validated; Region: ampG; PRK11010 65393009687 muropeptide transporter; Reviewed; Region: ampG; PRK11902 65393009688 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 65393009689 catalytic core [active] 65393009690 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 65393009691 Protein of unknown function, DUF393; Region: DUF393; cl01136 65393009692 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 65393009693 active site 65393009694 nucleophile elbow; other site 65393009695 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 65393009696 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 65393009697 active site 65393009698 metal binding site [ion binding]; metal-binding site 65393009699 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 65393009700 active site 65393009701 dinuclear metal binding site [ion binding]; other site 65393009702 dimerization interface [polypeptide binding]; other site 65393009703 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 65393009704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393009705 Coenzyme A binding pocket [chemical binding]; other site 65393009706 Response regulator receiver domain; Region: Response_reg; pfam00072 65393009707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393009708 active site 65393009709 phosphorylation site [posttranslational modification] 65393009710 intermolecular recognition site; other site 65393009711 dimerization interface [polypeptide binding]; other site 65393009712 RDD family; Region: RDD; cl00746 65393009713 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393009714 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393009715 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393009716 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393009717 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393009718 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393009719 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 65393009720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393009721 binding surface 65393009722 TPR motif; other site 65393009723 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 65393009724 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 65393009725 active site 65393009726 catalytic triad [active] 65393009727 oxyanion hole [active] 65393009728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393009729 S-adenosylmethionine binding site [chemical binding]; other site 65393009730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393009731 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 65393009732 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 65393009733 putative active site; other site 65393009734 catalytic residue [active] 65393009735 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 65393009736 active site 65393009737 putative substrate binding region [chemical binding]; other site 65393009738 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393009739 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 65393009740 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 65393009741 dihydropteroate synthase; Region: DHPS; TIGR01496 65393009742 substrate binding pocket [chemical binding]; other site 65393009743 dimer interface [polypeptide binding]; other site 65393009744 inhibitor binding site; inhibition site 65393009745 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 65393009746 substrate binding site [chemical binding]; other site 65393009747 dimer interface [polypeptide binding]; other site 65393009748 catalytic triad [active] 65393009749 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 65393009750 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 65393009751 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 65393009752 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 65393009753 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 65393009754 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 65393009755 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 65393009756 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393009757 putative active site [active] 65393009758 aspartate aminotransferase; Provisional; Region: PRK05942 65393009759 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 65393009760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393009761 homodimer interface [polypeptide binding]; other site 65393009762 catalytic residue [active] 65393009763 putative acetyltransferase; Provisional; Region: PRK03624 65393009764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393009765 Coenzyme A binding pocket [chemical binding]; other site 65393009766 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 65393009767 GAF domain; Region: GAF; cl00853 65393009768 Phytochrome region; Region: PHY; pfam00360 65393009769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393009770 dimer interface [polypeptide binding]; other site 65393009771 phosphorylation site [posttranslational modification] 65393009772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393009773 ATP binding site [chemical binding]; other site 65393009774 Mg2+ binding site [ion binding]; other site 65393009775 G-X-G motif; other site 65393009776 Response regulator receiver domain; Region: Response_reg; pfam00072 65393009777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393009778 active site 65393009779 phosphorylation site [posttranslational modification] 65393009780 intermolecular recognition site; other site 65393009781 dimerization interface [polypeptide binding]; other site 65393009782 enolase; Provisional; Region: eno; PRK00077 65393009783 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 65393009784 dimer interface [polypeptide binding]; other site 65393009785 metal binding site [ion binding]; metal-binding site 65393009786 substrate binding pocket [chemical binding]; other site 65393009787 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 65393009788 Protein of unknown function (DUF760); Region: DUF760; pfam05542 65393009789 hydrolase; Region: PLN02578 65393009790 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393009791 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393009792 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 65393009793 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 65393009794 active site 65393009795 Riboflavin kinase; Region: Flavokinase; cl03312 65393009796 MoxR-like ATPases [General function prediction only]; Region: COG0714 65393009797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393009798 Walker A motif; other site 65393009799 ATP binding site [chemical binding]; other site 65393009800 Walker B motif; other site 65393009801 arginine finger; other site 65393009802 Dihaem cytochrome c; Region: DHC; pfam09626 65393009803 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 65393009804 putative catalytic residue [active] 65393009805 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 65393009806 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393009807 iron-sulfur cluster binding protein, putative; Region: TIGR00276 65393009808 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 65393009809 4Fe-4S binding domain; Region: Fer4; cl02805 65393009810 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 65393009811 arginine decarboxylase; Provisional; Region: PRK05354 65393009812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393009813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 65393009814 dimer interface [polypeptide binding]; other site 65393009815 active site 65393009816 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 65393009817 catalytic residues [active] 65393009818 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 65393009819 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 65393009820 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 65393009821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393009822 FeS/SAM binding site; other site 65393009823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 65393009824 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 65393009825 mechanosensitive channel MscS; Provisional; Region: PRK10334 65393009826 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393009827 light-harvesting-like protein 3; Provisional; Region: PLN00014 65393009828 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 65393009829 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393009830 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 65393009831 metal ion-dependent adhesion site (MIDAS); other site 65393009832 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 65393009833 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 65393009834 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 65393009835 trimer interface [polypeptide binding]; other site 65393009836 active site 65393009837 substrate binding site [chemical binding]; other site 65393009838 CoA binding site [chemical binding]; other site 65393009839 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 65393009840 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 65393009841 C-terminal domain interface [polypeptide binding]; other site 65393009842 GSH binding site (G-site) [chemical binding]; other site 65393009843 dimer interface [polypeptide binding]; other site 65393009844 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 65393009845 N-terminal domain interface [polypeptide binding]; other site 65393009846 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 65393009847 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 65393009848 active site 65393009849 dimer interface [polypeptide binding]; other site 65393009850 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 65393009851 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 65393009852 tetramer interface [polypeptide binding]; other site 65393009853 active site 65393009854 Mg2+/Mn2+ binding site [ion binding]; other site 65393009855 malate synthase A; Region: malate_syn_A; TIGR01344 65393009856 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 65393009857 active site 65393009858 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 65393009859 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 65393009860 active site residue [active] 65393009861 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 65393009862 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 65393009863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393009864 homodimer interface [polypeptide binding]; other site 65393009865 catalytic residue [active] 65393009866 Protein of unknown function (DUF563); Region: DUF563; cl15705 65393009867 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 65393009868 TPP-binding site [chemical binding]; other site 65393009869 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 65393009870 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 65393009871 PYR/PP interface [polypeptide binding]; other site 65393009872 dimer interface [polypeptide binding]; other site 65393009873 TPP binding site [chemical binding]; other site 65393009874 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 65393009875 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 65393009876 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 65393009877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393009878 Probable transposase; Region: OrfB_IS605; pfam01385 65393009879 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393009880 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393009881 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 65393009882 transketolase; Region: PLN02790 65393009883 TPP-binding site [chemical binding]; other site 65393009884 dimer interface [polypeptide binding]; other site 65393009885 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 65393009886 PYR/PP interface [polypeptide binding]; other site 65393009887 dimer interface [polypeptide binding]; other site 65393009888 TPP binding site [chemical binding]; other site 65393009889 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 65393009890 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 65393009891 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 65393009892 dimer interface [polypeptide binding]; other site 65393009893 active site 65393009894 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393009895 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 65393009896 Cysteine-rich domain; Region: CCG; pfam02754 65393009897 Cysteine-rich domain; Region: CCG; pfam02754 65393009898 Acylphosphatase; Region: Acylphosphatase; cl00551 65393009899 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 65393009900 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 65393009901 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393009902 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 65393009903 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 65393009904 D-pathway; other site 65393009905 Putative ubiquinol binding site [chemical binding]; other site 65393009906 Low-spin heme (heme b) binding site [chemical binding]; other site 65393009907 Putative water exit pathway; other site 65393009908 Binuclear center (heme o3/CuB) [ion binding]; other site 65393009909 K-pathway; other site 65393009910 Putative proton exit pathway; other site 65393009911 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 65393009912 Subunit I/III interface [polypeptide binding]; other site 65393009913 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 65393009914 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 65393009915 active site 65393009916 substrate binding site [chemical binding]; other site 65393009917 metal binding site [ion binding]; metal-binding site 65393009918 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 65393009919 CP12 domain; Region: CP12; cl14670 65393009920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 65393009921 FIST N domain; Region: FIST; cl10701 65393009922 FIST C domain; Region: FIST_C; pfam10442 65393009923 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 65393009924 active site 65393009925 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393009926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393009927 binding surface 65393009928 TPR motif; other site 65393009929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393009930 binding surface 65393009931 TPR motif; other site 65393009932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393009933 binding surface 65393009934 TPR motif; other site 65393009935 Predicted permease; Region: DUF318; cl00487 65393009936 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 65393009937 DHH family; Region: DHH; pfam01368 65393009938 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 65393009939 catalytic core [active] 65393009940 citrate synthase; Provisional; Region: PRK14036 65393009941 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 65393009942 oxalacetate binding site [chemical binding]; other site 65393009943 citrylCoA binding site [chemical binding]; other site 65393009944 coenzyme A binding site [chemical binding]; other site 65393009945 catalytic triad [active] 65393009946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393009947 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393009948 GAF domain; Region: GAF; cl00853 65393009949 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393009950 GAF domain; Region: GAF; cl00853 65393009951 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393009952 GAF domain; Region: GAF; cl00853 65393009953 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 65393009954 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 65393009955 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 65393009956 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 65393009957 active site 65393009958 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 65393009959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393009960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393009961 dimer interface [polypeptide binding]; other site 65393009962 phosphorylation site [posttranslational modification] 65393009963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393009964 ATP binding site [chemical binding]; other site 65393009965 Mg2+ binding site [ion binding]; other site 65393009966 G-X-G motif; other site 65393009967 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393009968 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393009969 putative active site [active] 65393009970 magnesium chelatase subunit H; Provisional; Region: PLN03241 65393009971 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 65393009972 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 65393009973 Sugar fermentation stimulation protein; Region: SfsA; cl00647 65393009974 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 65393009975 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 65393009976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393009977 S-adenosylmethionine binding site [chemical binding]; other site 65393009978 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 65393009979 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 65393009980 active site 65393009981 catalytic tetrad [active] 65393009982 recombinase A; Provisional; Region: recA; PRK09354 65393009983 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 65393009984 hexamer interface [polypeptide binding]; other site 65393009985 Walker A motif; other site 65393009986 ATP binding site [chemical binding]; other site 65393009987 Walker B motif; other site 65393009988 Uncharacterized conserved protein [Function unknown]; Region: COG4938 65393009989 Uncharacterized conserved protein [Function unknown]; Region: COG4938 65393009990 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 65393009991 Cation transport protein; Region: TrkH; cl10514 65393009992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393009993 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 65393009994 Predicted membrane protein [Function unknown]; Region: COG4270 65393009995 UV-endonuclease UvdE; Region: UvdE; cl10036 65393009996 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 65393009997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 65393009998 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 65393009999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393010000 PAS fold; Region: PAS_3; pfam08447 65393010001 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393010002 GAF domain; Region: GAF; cl00853 65393010003 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393010004 metal binding site [ion binding]; metal-binding site 65393010005 active site 65393010006 I-site; other site 65393010007 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 65393010008 putative homotetramer interface [polypeptide binding]; other site 65393010009 putative homodimer interface [polypeptide binding]; other site 65393010010 putative metal binding site [ion binding]; other site 65393010011 putative homodimer-homodimer interface [polypeptide binding]; other site 65393010012 putative allosteric switch controlling residues; other site 65393010013 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 65393010014 phosphoglucomutase; Validated; Region: PRK07564 65393010015 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 65393010016 active site 65393010017 substrate binding site [chemical binding]; other site 65393010018 metal binding site [ion binding]; metal-binding site 65393010019 CHAT domain; Region: CHAT; cl02083 65393010020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393010021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 65393010022 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 65393010023 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 65393010024 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 65393010025 HsdM N-terminal domain; Region: HsdM_N; pfam12161 65393010026 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 65393010027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393010028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393010029 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 65393010030 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 65393010031 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 65393010032 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 65393010033 Helix-turn-helix domains; Region: HTH; cl00088 65393010034 Predicted transcriptional regulator [Transcription]; Region: COG1959 65393010035 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 65393010036 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 65393010037 hinge; other site 65393010038 active site 65393010039 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 65393010040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393010041 Walker A motif; other site 65393010042 ATP binding site [chemical binding]; other site 65393010043 Walker B motif; other site 65393010044 arginine finger; other site 65393010045 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 65393010046 protein-splicing catalytic site; other site 65393010047 thioester formation/cholesterol transfer; other site 65393010048 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 65393010049 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 65393010050 GIY-YIG motif/motif A; other site 65393010051 active site 65393010052 catalytic site [active] 65393010053 metal binding site [ion binding]; metal-binding site 65393010054 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 65393010055 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 65393010056 Cupin domain; Region: Cupin_2; cl09118 65393010057 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 65393010058 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 65393010059 active site 65393010060 metal binding site [ion binding]; metal-binding site 65393010061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393010062 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 65393010063 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 65393010064 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 65393010065 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 65393010066 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 65393010067 catalytic loop [active] 65393010068 iron binding site [ion binding]; other site 65393010069 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 65393010070 4Fe-4S binding domain; Region: Fer4; cl02805 65393010071 hybrid cluster protein; Provisional; Region: PRK05290 65393010072 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 65393010073 ACS interaction site; other site 65393010074 CODH interaction site; other site 65393010075 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 65393010076 hybrid metal cluster; other site 65393010077 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 65393010078 dimer interface [polypeptide binding]; other site 65393010079 [2Fe-2S] cluster binding site [ion binding]; other site 65393010080 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 65393010081 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 65393010082 SLBB domain; Region: SLBB; pfam10531 65393010083 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 65393010084 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 65393010085 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 65393010086 putative dimer interface [polypeptide binding]; other site 65393010087 [2Fe-2S] cluster binding site [ion binding]; other site 65393010088 Restriction endonuclease NotI; Region: NotI; pfam12183 65393010089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393010090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393010091 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 65393010092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393010093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 65393010094 putative substrate translocation pore; other site 65393010095 Rhomboid family; Region: Rhomboid; cl11446 65393010096 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 65393010097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393010098 dimer interface [polypeptide binding]; other site 65393010099 ABC-ATPase subunit interface; other site 65393010100 putative PBP binding loops; other site 65393010101 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 65393010102 signal recognition particle protein; Provisional; Region: PRK10867 65393010103 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 65393010104 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 65393010105 P loop; other site 65393010106 GTP binding site [chemical binding]; other site 65393010107 Signal peptide binding domain; Region: SRP_SPB; pfam02978 65393010108 molecular chaperone DnaK; Provisional; Region: PRK13411 65393010109 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 65393010110 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 65393010111 dimer interface [polypeptide binding]; other site 65393010112 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 65393010113 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 65393010114 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 65393010115 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 65393010116 Walker A motif; other site 65393010117 ATP binding site [chemical binding]; other site 65393010118 Walker B motif; other site 65393010119 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 65393010120 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 65393010121 Walker A motif; other site 65393010122 ATP binding site [chemical binding]; other site 65393010123 Walker B motif; other site 65393010124 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 65393010125 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 65393010126 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 65393010127 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393010128 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 65393010129 30S subunit binding site; other site 65393010130 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 65393010131 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393010132 phosphopeptide binding site; other site 65393010133 cyclase homology domain; Region: CHD; cd07302 65393010134 nucleotidyl binding site; other site 65393010135 metal binding site [ion binding]; metal-binding site 65393010136 dimer interface [polypeptide binding]; other site 65393010137 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 65393010138 Bacitracin resistance protein BacA; Region: BacA; cl00858 65393010139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393010140 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 65393010141 G1 box; other site 65393010142 GTP/Mg2+ binding site [chemical binding]; other site 65393010143 Switch I region; other site 65393010144 G2 box; other site 65393010145 G4 box; other site 65393010146 Domain of unknown function (DUF697); Region: DUF697; cl12064 65393010147 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 65393010148 Probable Catalytic site; other site 65393010149 metal-binding site 65393010150 hypothetical protein; Provisional; Region: PRK07208 65393010151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010152 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 65393010153 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393010154 active site 65393010155 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393010156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393010157 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393010158 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393010159 active site 65393010160 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393010161 colanic acid exporter; Provisional; Region: PRK10459 65393010162 MatE; Region: MatE; cl10513 65393010163 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393010164 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393010165 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 65393010166 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393010167 active site 65393010168 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 65393010169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010170 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 65393010171 DNA repair protein RadA; Provisional; Region: PRK11823 65393010172 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 65393010173 Walker A motif/ATP binding site; other site 65393010174 ATP binding site [chemical binding]; other site 65393010175 Walker B motif; other site 65393010176 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 65393010177 Ycf27; Reviewed; Region: orf27; CHL00148 65393010178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393010179 active site 65393010180 phosphorylation site [posttranslational modification] 65393010181 intermolecular recognition site; other site 65393010182 dimerization interface [polypeptide binding]; other site 65393010183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393010184 DNA binding site [nucleotide binding] 65393010185 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 65393010186 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 65393010187 putative active site pocket [active] 65393010188 dimerization interface [polypeptide binding]; other site 65393010189 putative catalytic residue [active] 65393010190 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393010191 GAF domain; Region: GAF; cl00853 65393010192 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393010193 GAF domain; Region: GAF; cl00853 65393010194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393010195 dimer interface [polypeptide binding]; other site 65393010196 phosphorylation site [posttranslational modification] 65393010197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393010198 ATP binding site [chemical binding]; other site 65393010199 Mg2+ binding site [ion binding]; other site 65393010200 G-X-G motif; other site 65393010201 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393010202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393010203 Walker A motif; other site 65393010204 ATP binding site [chemical binding]; other site 65393010205 Walker B motif; other site 65393010206 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393010207 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 65393010208 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393010209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393010210 Probable transposase; Region: OrfB_IS605; pfam01385 65393010211 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393010212 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 65393010213 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 65393010214 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 65393010215 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 65393010216 RNA/DNA hybrid binding site [nucleotide binding]; other site 65393010217 active site 65393010218 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 65393010219 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 65393010220 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 65393010221 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 65393010222 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 65393010223 XisI protein; Region: XisI; pfam08869 65393010224 Protein of unknown function DUF262; Region: DUF262; cl14890 65393010225 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393010226 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 65393010227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010228 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 65393010229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010230 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 65393010231 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 65393010232 active site 65393010233 HIGH motif; other site 65393010234 nucleotide binding site [chemical binding]; other site 65393010235 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 65393010236 active site 65393010237 KMSKS motif; other site 65393010238 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 65393010239 tRNA binding surface [nucleotide binding]; other site 65393010240 anticodon binding site; other site 65393010241 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 65393010242 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 65393010243 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 65393010244 isoform II; Region: PAF-AH_p_II; pfam03403 65393010245 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 65393010246 DNA polymerase I; Provisional; Region: PRK05755 65393010247 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 65393010248 active site 65393010249 metal binding site 1 [ion binding]; metal-binding site 65393010250 putative 5' ssDNA interaction site; other site 65393010251 metal binding site 3; metal-binding site 65393010252 metal binding site 2 [ion binding]; metal-binding site 65393010253 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 65393010254 putative DNA binding site [nucleotide binding]; other site 65393010255 putative metal binding site [ion binding]; other site 65393010256 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 65393010257 active site 65393010258 catalytic site [active] 65393010259 substrate binding site [chemical binding]; other site 65393010260 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 65393010261 active site 65393010262 DNA binding site [nucleotide binding] 65393010263 catalytic site [active] 65393010264 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 65393010265 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 65393010266 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 65393010267 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 65393010268 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 65393010269 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 65393010270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393010271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393010272 active site 65393010273 phosphorylation site [posttranslational modification] 65393010274 intermolecular recognition site; other site 65393010275 dimerization interface [polypeptide binding]; other site 65393010276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393010277 DNA binding site [nucleotide binding] 65393010278 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 65393010279 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 65393010280 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 65393010281 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 65393010282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 65393010283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393010284 homodimer interface [polypeptide binding]; other site 65393010285 catalytic residue [active] 65393010286 Fasciclin domain; Region: Fasciclin; cl02663 65393010287 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 65393010288 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 65393010289 NAD binding site [chemical binding]; other site 65393010290 homodimer interface [polypeptide binding]; other site 65393010291 active site 65393010292 substrate binding site [chemical binding]; other site 65393010293 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 65393010294 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393010295 active site 65393010296 ABC-2 type transporter; Region: ABC2_membrane; cl11417 65393010297 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 65393010298 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 65393010299 Walker A/P-loop; other site 65393010300 ATP binding site [chemical binding]; other site 65393010301 Q-loop/lid; other site 65393010302 ABC transporter signature motif; other site 65393010303 Walker B; other site 65393010304 D-loop; other site 65393010305 H-loop/switch region; other site 65393010306 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 65393010307 putative carbohydrate binding site [chemical binding]; other site 65393010308 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393010309 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393010310 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 65393010311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393010312 active site 65393010313 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393010314 active site 65393010315 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393010316 Radical SAM superfamily; Region: Radical_SAM; pfam04055 65393010317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393010318 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 65393010319 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 65393010320 ribosomal protein L20; Region: rpl20; CHL00068 65393010321 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 65393010322 23S rRNA binding site [nucleotide binding]; other site 65393010323 L21 binding site [polypeptide binding]; other site 65393010324 L13 binding site [polypeptide binding]; other site 65393010325 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 65393010326 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393010327 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 65393010328 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 65393010329 [2Fe-2S] cluster binding site [ion binding]; other site 65393010330 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 65393010331 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 65393010332 active site 65393010333 metal binding site [ion binding]; metal-binding site 65393010334 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 65393010335 catalytic residues [active] 65393010336 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 65393010337 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 65393010338 cofactor binding site; other site 65393010339 DNA binding site [nucleotide binding] 65393010340 substrate interaction site [chemical binding]; other site 65393010341 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 65393010342 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 65393010343 dimerization interface [polypeptide binding]; other site 65393010344 active site 65393010345 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 65393010346 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 65393010347 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 65393010348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010349 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 65393010350 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 65393010351 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 65393010352 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 65393010353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010354 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 65393010355 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 65393010356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010357 CoA-ligase; Region: Ligase_CoA; pfam00549 65393010358 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 65393010359 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393010360 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 65393010361 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 65393010362 glycogen binding site [chemical binding]; other site 65393010363 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 65393010364 active site 65393010365 catalytic site [active] 65393010366 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 65393010367 FtsH Extracellular; Region: FtsH_ext; pfam06480 65393010368 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 65393010369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393010370 Walker A motif; other site 65393010371 ATP binding site [chemical binding]; other site 65393010372 Walker B motif; other site 65393010373 arginine finger; other site 65393010374 Peptidase family M41; Region: Peptidase_M41; pfam01434 65393010375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010376 geranylgeranyl reductase; Region: ChlP; TIGR02028 65393010377 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 65393010378 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 65393010379 Zn binding site [ion binding]; other site 65393010380 Rhomboid family; Region: Rhomboid; cl11446 65393010381 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 65393010382 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 65393010383 catalytic triad [active] 65393010384 Peptidase family M48; Region: Peptidase_M48; cl12018 65393010385 Helix-turn-helix domains; Region: HTH; cl00088 65393010386 alanine dehydrogenase; Region: alaDH; TIGR00518 65393010387 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 65393010388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010389 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 65393010390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393010391 active site 65393010392 phosphorylation site [posttranslational modification] 65393010393 intermolecular recognition site; other site 65393010394 dimerization interface [polypeptide binding]; other site 65393010395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393010396 DNA binding site [nucleotide binding] 65393010397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393010398 dimerization interface [polypeptide binding]; other site 65393010399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393010400 dimer interface [polypeptide binding]; other site 65393010401 phosphorylation site [posttranslational modification] 65393010402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393010403 ATP binding site [chemical binding]; other site 65393010404 G-X-G motif; other site 65393010405 TIR domain; Region: TIR; cl02060 65393010406 TIR domain; Region: TIR; cl02060 65393010407 Divergent AAA domain; Region: AAA_4; pfam04326 65393010408 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 65393010409 light-harvesting-like protein 3; Provisional; Region: PLN00014 65393010410 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 65393010411 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 65393010412 HIGH motif; other site 65393010413 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 65393010414 active site 65393010415 KMSKS motif; other site 65393010416 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393010417 putative active site [active] 65393010418 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 65393010419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393010420 Restriction endonuclease; Region: Mrr_cat; cl00747 65393010421 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393010422 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 65393010423 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 65393010424 active site 65393010425 catalytic tetrad [active] 65393010426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393010427 Predicted GTPase [General function prediction only]; Region: COG3596 65393010428 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 65393010429 G1 box; other site 65393010430 GTP/Mg2+ binding site [chemical binding]; other site 65393010431 Switch I region; other site 65393010432 G2 box; other site 65393010433 Switch II region; other site 65393010434 G3 box; other site 65393010435 G4 box; other site 65393010436 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 65393010437 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 65393010438 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 65393010439 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 65393010440 SLBB domain; Region: SLBB; pfam10531 65393010441 Chain length determinant protein; Region: Wzz; cl01623 65393010442 tyrosine kinase; Provisional; Region: PRK11519 65393010443 Chain length determinant protein; Region: Wzz; cl01623 65393010444 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 65393010445 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 65393010446 Nucleotide binding site [chemical binding]; other site 65393010447 DTAP/Switch II; other site 65393010448 Switch I; other site 65393010449 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 65393010450 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 65393010451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010452 binding surface 65393010453 TPR motif; other site 65393010454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393010455 Mg chelatase-related protein; Region: TIGR00368 65393010456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393010457 Walker A motif; other site 65393010458 ATP binding site [chemical binding]; other site 65393010459 Walker B motif; other site 65393010460 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 65393010461 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 65393010462 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 65393010463 active site 65393010464 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 65393010465 amidophosphoribosyltransferase; Provisional; Region: PRK07349 65393010466 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 65393010467 active site 65393010468 tetramer interface [polypeptide binding]; other site 65393010469 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393010470 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393010471 putative active site [active] 65393010472 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 65393010473 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 65393010474 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 65393010475 dimerization interface [polypeptide binding]; other site 65393010476 ATP binding site [chemical binding]; other site 65393010477 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 65393010478 dimerization interface [polypeptide binding]; other site 65393010479 ATP binding site [chemical binding]; other site 65393010480 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 65393010481 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 65393010482 tetramerization interface [polypeptide binding]; other site 65393010483 active site 65393010484 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 65393010485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393010486 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 65393010487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393010488 motif II; other site 65393010489 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 65393010490 Uncharacterized conserved protein [Function unknown]; Region: COG3349 65393010491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010492 glutathione reductase; Validated; Region: PRK06116 65393010493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010494 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 65393010495 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 65393010496 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 65393010497 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 65393010498 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 65393010499 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 65393010500 putative active site [active] 65393010501 putative NTP binding site [chemical binding]; other site 65393010502 putative nucleic acid binding site [nucleotide binding]; other site 65393010503 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 65393010504 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 65393010505 active site 65393010506 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 65393010507 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 65393010508 active site 65393010509 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393010510 putative active site [active] 65393010511 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 65393010512 inhibitor binding site; inhibition site 65393010513 catalytic motif [active] 65393010514 Catalytic residue [active] 65393010515 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 65393010516 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 65393010517 active site 65393010518 homodimer interface [polypeptide binding]; other site 65393010519 catalytic site [active] 65393010520 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 65393010521 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 65393010522 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 65393010523 Stage II sporulation protein; Region: SpoIID; pfam08486 65393010524 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 65393010525 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393010526 P-loop; other site 65393010527 Magnesium ion binding site [ion binding]; other site 65393010528 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393010529 Magnesium ion binding site [ion binding]; other site 65393010530 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 65393010531 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 65393010532 active site 65393010533 metal binding site [ion binding]; metal-binding site 65393010534 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 65393010535 active site 65393010536 metal binding site [ion binding]; metal-binding site 65393010537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010538 binding surface 65393010539 TPR motif; other site 65393010540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010541 binding surface 65393010542 TPR motif; other site 65393010543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010544 binding surface 65393010545 TPR motif; other site 65393010546 Cytochrome c; Region: Cytochrom_C; cl11414 65393010547 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 65393010548 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 65393010549 RNA/DNA binding site [nucleotide binding]; other site 65393010550 RRM dimerization site [polypeptide binding]; other site 65393010551 Peptidase family M48; Region: Peptidase_M48; cl12018 65393010552 TROVE domain; Region: TROVE; pfam05731 65393010553 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 65393010554 Peptidase family M48; Region: Peptidase_M48; cl12018 65393010555 Probable transposase; Region: OrfB_IS605; pfam01385 65393010556 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393010557 glycogen branching enzyme; Provisional; Region: PRK12313 65393010558 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 65393010559 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 65393010560 active site 65393010561 catalytic site [active] 65393010562 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 65393010563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010564 binding surface 65393010565 TPR motif; other site 65393010566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010567 TPR motif; other site 65393010568 binding surface 65393010569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010570 binding surface 65393010571 TPR motif; other site 65393010572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393010573 TPR motif; other site 65393010574 binding surface 65393010575 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 65393010576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393010577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393010578 DNA binding residues [nucleotide binding] 65393010579 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 65393010580 XisI protein; Region: XisI; pfam08869 65393010581 XisH protein; Region: XisH; pfam08814 65393010582 Phd_YefM; Region: PhdYeFM; cl09153 65393010583 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393010584 active site 65393010585 NTP binding site [chemical binding]; other site 65393010586 metal binding triad [ion binding]; metal-binding site 65393010587 antibiotic binding site [chemical binding]; other site 65393010588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010589 binding surface 65393010590 TPR motif; other site 65393010591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010592 TPR motif; other site 65393010593 binding surface 65393010594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010595 TPR motif; other site 65393010596 binding surface 65393010597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010598 TPR motif; other site 65393010599 binding surface 65393010600 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 65393010601 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393010602 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393010603 DNA binding residues [nucleotide binding] 65393010604 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 65393010605 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 65393010606 metal-binding site [ion binding] 65393010607 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393010608 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393010609 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 65393010610 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; cl11557 65393010611 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 65393010612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010613 oligomerization interface [polypeptide binding]; other site 65393010614 active site 65393010615 NAD+ binding site [chemical binding]; other site 65393010616 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 65393010617 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393010618 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 65393010619 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 65393010620 isoform II; Region: PAF-AH_p_II; pfam03403 65393010621 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 65393010622 Peptidase family M48; Region: Peptidase_M48; cl12018 65393010623 Protein of unknown function (DUF433); Region: DUF433; cl01030 65393010624 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; cl15400 65393010625 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 65393010626 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; cl15400 65393010627 ABC-2 type transporter; Region: ABC2_membrane; cl11417 65393010628 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 65393010629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393010630 Walker A/P-loop; other site 65393010631 ATP binding site [chemical binding]; other site 65393010632 Q-loop/lid; other site 65393010633 ABC transporter signature motif; other site 65393010634 Walker B; other site 65393010635 D-loop; other site 65393010636 H-loop/switch region; other site 65393010637 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 65393010638 Dimer interface [polypeptide binding]; other site 65393010639 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 65393010640 putative hydrophobic ligand binding site [chemical binding]; other site 65393010641 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 65393010642 TM2 domain; Region: TM2; cl00984 65393010643 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 65393010644 putative GSH binding site [chemical binding]; other site 65393010645 catalytic residues [active] 65393010646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393010647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393010648 active site 65393010649 phosphorylation site [posttranslational modification] 65393010650 intermolecular recognition site; other site 65393010651 dimerization interface [polypeptide binding]; other site 65393010652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393010653 DNA binding site [nucleotide binding] 65393010654 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 65393010655 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 65393010656 Walker A/P-loop; other site 65393010657 ATP binding site [chemical binding]; other site 65393010658 Q-loop/lid; other site 65393010659 ABC transporter signature motif; other site 65393010660 Walker B; other site 65393010661 D-loop; other site 65393010662 H-loop/switch region; other site 65393010663 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 65393010664 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 65393010665 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 65393010666 chaperone protein DnaJ; Provisional; Region: PRK14298 65393010667 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 65393010668 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393010669 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 65393010670 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393010671 structural tetrad; other site 65393010672 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393010673 structural tetrad; other site 65393010674 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 65393010675 alpha-gamma subunit interface [polypeptide binding]; other site 65393010676 beta-gamma subunit interface [polypeptide binding]; other site 65393010677 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 65393010678 gamma-beta subunit interface [polypeptide binding]; other site 65393010679 alpha-beta subunit interface [polypeptide binding]; other site 65393010680 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393010681 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393010682 Switch II region; other site 65393010683 G4 box; other site 65393010684 G5 box; other site 65393010685 UreD urease accessory protein; Region: UreD; cl00530 65393010686 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 65393010687 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 65393010688 dimer interface [polypeptide binding]; other site 65393010689 catalytic residues [active] 65393010690 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 65393010691 UreF; Region: UreF; pfam01730 65393010692 urease subunit alpha; Reviewed; Region: ureC; PRK13207 65393010693 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 65393010694 subunit interactions [polypeptide binding]; other site 65393010695 active site 65393010696 flap region; other site 65393010697 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 65393010698 Phycobilisome protein; Region: Phycobilisome; cl08227 65393010699 hydrolase, alpha/beta fold family protein; Region: PLN02679 65393010700 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393010701 Calicivirus coat protein; Region: Calici_coat; pfam00915 65393010702 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 65393010703 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 65393010704 active site 65393010705 metal binding site [ion binding]; metal-binding site 65393010706 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 65393010707 active site 65393010708 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 65393010709 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 65393010710 DXD motif; other site 65393010711 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 65393010712 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 65393010713 Walker A/P-loop; other site 65393010714 ATP binding site [chemical binding]; other site 65393010715 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 65393010716 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 65393010717 ABC transporter signature motif; other site 65393010718 Walker B; other site 65393010719 D-loop; other site 65393010720 H-loop/switch region; other site 65393010721 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 65393010722 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 65393010723 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393010724 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 65393010725 Walker A/P-loop; other site 65393010726 ATP binding site [chemical binding]; other site 65393010727 Q-loop/lid; other site 65393010728 ABC transporter signature motif; other site 65393010729 Walker B; other site 65393010730 D-loop; other site 65393010731 H-loop/switch region; other site 65393010732 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 65393010733 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 65393010734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393010735 motif II; other site 65393010736 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 65393010737 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393010738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393010739 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393010740 putative active site [active] 65393010741 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 65393010742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393010743 Walker A motif; other site 65393010744 ATP binding site [chemical binding]; other site 65393010745 Walker B motif; other site 65393010746 arginine finger; other site 65393010747 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 65393010748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393010749 Helix-turn-helix domains; Region: HTH; cl00088 65393010750 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 65393010751 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 65393010752 iron-sulfur cluster [ion binding]; other site 65393010753 [2Fe-2S] cluster binding site [ion binding]; other site 65393010754 L-lactate permease; Region: Lactate_perm; cl00701 65393010755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393010756 PAS fold; Region: PAS_4; pfam08448 65393010757 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393010758 PAS fold; Region: PAS_3; pfam08447 65393010759 putative active site [active] 65393010760 heme pocket [chemical binding]; other site 65393010761 PAS domain S-box; Region: sensory_box; TIGR00229 65393010762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393010763 putative active site [active] 65393010764 heme pocket [chemical binding]; other site 65393010765 PAS fold; Region: PAS_4; pfam08448 65393010766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393010767 putative active site [active] 65393010768 heme pocket [chemical binding]; other site 65393010769 PAS domain S-box; Region: sensory_box; TIGR00229 65393010770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393010771 putative active site [active] 65393010772 heme pocket [chemical binding]; other site 65393010773 PAS domain S-box; Region: sensory_box; TIGR00229 65393010774 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393010775 putative active site [active] 65393010776 heme pocket [chemical binding]; other site 65393010777 PAS domain S-box; Region: sensory_box; TIGR00229 65393010778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393010779 putative active site [active] 65393010780 heme pocket [chemical binding]; other site 65393010781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393010782 dimer interface [polypeptide binding]; other site 65393010783 phosphorylation site [posttranslational modification] 65393010784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393010785 ATP binding site [chemical binding]; other site 65393010786 Mg2+ binding site [ion binding]; other site 65393010787 G-X-G motif; other site 65393010788 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 65393010789 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 65393010790 putative NAD(P) binding site [chemical binding]; other site 65393010791 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 65393010792 catalytic residue [active] 65393010793 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 65393010794 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 65393010795 Walker A/P-loop; other site 65393010796 ATP binding site [chemical binding]; other site 65393010797 Q-loop/lid; other site 65393010798 ABC transporter signature motif; other site 65393010799 Walker B; other site 65393010800 D-loop; other site 65393010801 H-loop/switch region; other site 65393010802 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 65393010803 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 65393010804 Walker A/P-loop; other site 65393010805 ATP binding site [chemical binding]; other site 65393010806 Q-loop/lid; other site 65393010807 ABC transporter signature motif; other site 65393010808 Walker B; other site 65393010809 D-loop; other site 65393010810 H-loop/switch region; other site 65393010811 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 65393010812 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393010813 putative active site [active] 65393010814 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 65393010815 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 65393010816 active site 65393010817 nucleophile elbow; other site 65393010818 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393010819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393010820 ScaI restriction endonuclease; Region: RE_ScaI; pfam09569 65393010821 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 65393010822 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 65393010823 inhibitor-cofactor binding pocket; inhibition site 65393010824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393010825 catalytic residue [active] 65393010826 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 65393010827 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 65393010828 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 65393010829 Ligand binding site; other site 65393010830 Putative Catalytic site; other site 65393010831 DXD motif; other site 65393010832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393010833 Probable transposase; Region: OrfB_IS605; pfam01385 65393010834 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393010835 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 65393010836 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 65393010837 putative active site [active] 65393010838 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 65393010839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393010840 FeS/SAM binding site; other site 65393010841 HemN C-terminal region; Region: HemN_C; pfam06969 65393010842 glycogen synthase; Provisional; Region: glgA; PRK00654 65393010843 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 65393010844 ADP-binding pocket [chemical binding]; other site 65393010845 homodimer interface [polypeptide binding]; other site 65393010846 NeuB family; Region: NeuB; cl00496 65393010847 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 65393010848 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 65393010849 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 65393010850 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 65393010851 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 65393010852 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 65393010853 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 65393010854 classical (c) SDRs; Region: SDR_c; cd05233 65393010855 NAD(P) binding site [chemical binding]; other site 65393010856 active site 65393010857 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 65393010858 proposed catalytic triad [active] 65393010859 conserved cys residue [active] 65393010860 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 65393010861 Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205 65393010862 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 65393010863 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 65393010864 RuvA N terminal domain; Region: RuvA_N; pfam01330 65393010865 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 65393010866 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 65393010867 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393010868 active site 65393010869 motif I; other site 65393010870 motif II; other site 65393010871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393010872 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 65393010873 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 65393010874 RES domain; Region: RES; cl02411 65393010875 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 65393010876 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 65393010877 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 65393010878 Ligand Binding Site [chemical binding]; other site 65393010879 GTPase Era; Reviewed; Region: era; PRK00089 65393010880 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 65393010881 G1 box; other site 65393010882 GTP/Mg2+ binding site [chemical binding]; other site 65393010883 Switch I region; other site 65393010884 G2 box; other site 65393010885 Switch II region; other site 65393010886 G3 box; other site 65393010887 G4 box; other site 65393010888 G5 box; other site 65393010889 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 65393010890 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 65393010891 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393010892 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393010893 Walker A/P-loop; other site 65393010894 ATP binding site [chemical binding]; other site 65393010895 Q-loop/lid; other site 65393010896 ABC transporter signature motif; other site 65393010897 Walker B; other site 65393010898 D-loop; other site 65393010899 H-loop/switch region; other site 65393010900 CsbD-like; Region: CsbD; cl01888 65393010901 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 65393010902 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 65393010903 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 65393010904 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 65393010905 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 65393010906 putative active site [active] 65393010907 catalytic residue [active] 65393010908 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 65393010909 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 65393010910 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 65393010911 nickel binding site [ion binding]; other site 65393010912 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 65393010913 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 65393010914 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 65393010915 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 65393010916 putative active site [active] 65393010917 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 65393010918 putative active site [active] 65393010919 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 65393010920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393010921 TPR motif; other site 65393010922 binding surface 65393010923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393010924 binding surface 65393010925 TPR motif; other site 65393010926 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 65393010927 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 65393010928 FtsX-like permease family; Region: FtsX; pfam02687 65393010929 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 65393010930 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 65393010931 Surface antigen; Region: Bac_surface_Ag; cl03097 65393010932 Helix-turn-helix domains; Region: HTH; cl00088 65393010933 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393010934 putative active site [active] 65393010935 YtxH-like protein; Region: YtxH; cl02079 65393010936 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 65393010937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393010938 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393010939 Probable transposase; Region: OrfB_IS605; pfam01385 65393010940 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393010941 Protein kinase domain; Region: Pkinase; pfam00069 65393010942 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393010943 active site 65393010944 ATP binding site [chemical binding]; other site 65393010945 substrate binding site [chemical binding]; other site 65393010946 activation loop (A-loop); other site 65393010947 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393010948 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393010949 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393010950 Uncharacterised protein family UPF0546; Region: UPF0546; pfam10639 65393010951 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 65393010952 TIGR01777 family protein; Region: yfcH 65393010953 putative NAD(P) binding site [chemical binding]; other site 65393010954 putative active site [active] 65393010955 Psb28 protein; Region: Psb28; cl04326 65393010956 PetM family of cytochrome b6f complex subunit 7; Region: PetM; cl15715 65393010957 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 65393010958 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 65393010959 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 65393010960 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 65393010961 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 65393010962 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 65393010963 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 65393010964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010965 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 65393010966 dimer interface [polypeptide binding]; other site 65393010967 active site 65393010968 Schiff base residues; other site 65393010969 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393010970 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393010971 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 65393010972 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 65393010973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393010974 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393010975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393010976 DNA binding residues [nucleotide binding] 65393010977 Protein of unknown function (DUF760); Region: DUF760; pfam05542 65393010978 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 65393010979 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 65393010980 minor groove reading motif; other site 65393010981 helix-hairpin-helix signature motif; other site 65393010982 substrate binding pocket [chemical binding]; other site 65393010983 active site 65393010984 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 65393010985 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 65393010986 active site 65393010987 8-oxo-dGMP binding site [chemical binding]; other site 65393010988 nudix motif; other site 65393010989 metal binding site [ion binding]; metal-binding site 65393010990 chromosome segregation protein; Provisional; Region: PRK03918 65393010991 Uncharacterized conserved protein [Function unknown]; Region: COG5592 65393010992 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 65393010993 Cation efflux family; Region: Cation_efflux; cl00316 65393010994 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 65393010995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393010996 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 65393010997 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 65393010998 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 65393010999 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 65393011000 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 65393011001 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 65393011002 Active Sites [active] 65393011003 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 65393011004 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 65393011005 isoform II; Region: PAF-AH_p_II; pfam03403 65393011006 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 65393011007 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 65393011008 isoform II; Region: PAF-AH_p_II; pfam03403 65393011009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393011010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011011 active site 65393011012 phosphorylation site [posttranslational modification] 65393011013 intermolecular recognition site; other site 65393011014 dimerization interface [polypeptide binding]; other site 65393011015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393011016 DNA binding site [nucleotide binding] 65393011017 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 65393011018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011019 active site 65393011020 phosphorylation site [posttranslational modification] 65393011021 intermolecular recognition site; other site 65393011022 dimerization interface [polypeptide binding]; other site 65393011023 Response regulator receiver domain; Region: Response_reg; pfam00072 65393011024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011025 active site 65393011026 phosphorylation site [posttranslational modification] 65393011027 intermolecular recognition site; other site 65393011028 dimerization interface [polypeptide binding]; other site 65393011029 CHASE3 domain; Region: CHASE3; cl05000 65393011030 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 65393011031 PAS domain S-box; Region: sensory_box; TIGR00229 65393011032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393011033 PAS domain S-box; Region: sensory_box; TIGR00229 65393011034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393011035 putative active site [active] 65393011036 heme pocket [chemical binding]; other site 65393011037 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 65393011038 PAS domain S-box; Region: sensory_box; TIGR00229 65393011039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393011040 putative active site [active] 65393011041 heme pocket [chemical binding]; other site 65393011042 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 65393011043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393011044 putative active site [active] 65393011045 heme pocket [chemical binding]; other site 65393011046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393011047 dimer interface [polypeptide binding]; other site 65393011048 phosphorylation site [posttranslational modification] 65393011049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393011050 ATP binding site [chemical binding]; other site 65393011051 Mg2+ binding site [ion binding]; other site 65393011052 G-X-G motif; other site 65393011053 Response regulator receiver domain; Region: Response_reg; pfam00072 65393011054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011055 active site 65393011056 phosphorylation site [posttranslational modification] 65393011057 intermolecular recognition site; other site 65393011058 dimerization interface [polypeptide binding]; other site 65393011059 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 65393011060 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 65393011061 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 65393011062 chorismate binding enzyme; Region: Chorismate_bind; cl10555 65393011063 PsaD; Region: PsaD; cl03639 65393011064 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 65393011065 4Fe-4S binding domain; Region: Fer4; cl02805 65393011066 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 65393011067 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 65393011068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393011069 Walker A motif; other site 65393011070 ATP binding site [chemical binding]; other site 65393011071 Walker B motif; other site 65393011072 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 65393011073 RxxxH motif; other site 65393011074 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 65393011075 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 65393011076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393011077 Walker A/P-loop; other site 65393011078 ATP binding site [chemical binding]; other site 65393011079 Q-loop/lid; other site 65393011080 exonuclease SbcC; Region: sbcc; TIGR00618 65393011081 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 65393011082 ABC transporter signature motif; other site 65393011083 Walker B; other site 65393011084 D-loop; other site 65393011085 H-loop/switch region; other site 65393011086 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 65393011087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011089 FOG: CBS domain [General function prediction only]; Region: COG0517 65393011090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 65393011091 PAS domain S-box; Region: sensory_box; TIGR00229 65393011092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393011093 putative active site [active] 65393011094 heme pocket [chemical binding]; other site 65393011095 PAS fold; Region: PAS_4; pfam08448 65393011096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393011097 putative active site [active] 65393011098 heme pocket [chemical binding]; other site 65393011099 PAS domain S-box; Region: sensory_box; TIGR00229 65393011100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393011101 putative active site [active] 65393011102 heme pocket [chemical binding]; other site 65393011103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 65393011104 Histidine kinase; Region: HisKA_2; cl06527 65393011105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393011106 ATP binding site [chemical binding]; other site 65393011107 Mg2+ binding site [ion binding]; other site 65393011108 G-X-G motif; other site 65393011109 Response regulator receiver domain; Region: Response_reg; pfam00072 65393011110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011111 active site 65393011112 phosphorylation site [posttranslational modification] 65393011113 intermolecular recognition site; other site 65393011114 dimerization interface [polypeptide binding]; other site 65393011115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 65393011116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393011117 dimer interface [polypeptide binding]; other site 65393011118 phosphorylation site [posttranslational modification] 65393011119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393011120 ATP binding site [chemical binding]; other site 65393011121 Mg2+ binding site [ion binding]; other site 65393011122 G-X-G motif; other site 65393011123 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 65393011124 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 65393011125 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 65393011126 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 65393011127 TPP-binding site; other site 65393011128 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 65393011129 PYR/PP interface [polypeptide binding]; other site 65393011130 dimer interface [polypeptide binding]; other site 65393011131 TPP binding site [chemical binding]; other site 65393011132 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 65393011133 Domain of unknown function DUF140; Region: DUF140; cl00510 65393011134 mce related protein; Region: MCE; cl15431 65393011135 mce related protein; Region: MCE; cl15431 65393011136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 65393011137 putative substrate translocation pore; other site 65393011138 phosphate:H+ symporter; Region: 2A0109; TIGR00887 65393011139 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 65393011140 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 65393011141 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393011142 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393011143 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 65393011144 anti sigma factor interaction site; other site 65393011145 regulatory phosphorylation site [posttranslational modification]; other site 65393011146 Bacterial sugar transferase; Region: Bac_transf; cl00939 65393011147 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 65393011148 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393011149 active site 65393011150 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 65393011151 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393011152 active site 65393011153 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393011154 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 65393011155 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 65393011156 Walker A/P-loop; other site 65393011157 ATP binding site [chemical binding]; other site 65393011158 Q-loop/lid; other site 65393011159 ABC transporter signature motif; other site 65393011160 Walker B; other site 65393011161 D-loop; other site 65393011162 H-loop/switch region; other site 65393011163 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 65393011164 Glutamine amidotransferase class-I; Region: GATase; pfam00117 65393011165 glutamine binding [chemical binding]; other site 65393011166 catalytic triad [active] 65393011167 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 65393011168 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 65393011169 chorismate binding enzyme; Region: Chorismate_bind; cl10555 65393011170 Chorismate mutase type II; Region: CM_2; cl00693 65393011171 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 65393011172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011174 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 65393011175 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 65393011176 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 65393011177 trimer interface [polypeptide binding]; other site 65393011178 active site 65393011179 substrate binding site [chemical binding]; other site 65393011180 CoA binding site [chemical binding]; other site 65393011181 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393011182 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393011183 Sulfatase; Region: Sulfatase; cl10460 65393011184 Sulfatase; Region: Sulfatase; cl10460 65393011185 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 65393011186 putative metal binding site [ion binding]; other site 65393011187 Sulfatase; Region: Sulfatase; cl10460 65393011188 Sulfatase; Region: Sulfatase; cl10460 65393011189 Sulfatase; Region: Sulfatase; cl10460 65393011190 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 65393011191 Chain length determinant protein; Region: Wzz; cl01623 65393011192 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 65393011193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393011194 active site 65393011195 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 65393011196 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 65393011197 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 65393011198 SLBB domain; Region: SLBB; pfam10531 65393011199 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 65393011200 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 65393011201 putative binding surface; other site 65393011202 active site 65393011203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393011204 ATP binding site [chemical binding]; other site 65393011205 Mg2+ binding site [ion binding]; other site 65393011206 G-X-G motif; other site 65393011207 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 65393011208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011209 active site 65393011210 phosphorylation site [posttranslational modification] 65393011211 intermolecular recognition site; other site 65393011212 dimerization interface [polypeptide binding]; other site 65393011213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 65393011214 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 65393011215 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 65393011216 Response regulator receiver domain; Region: Response_reg; pfam00072 65393011217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011218 active site 65393011219 phosphorylation site [posttranslational modification] 65393011220 intermolecular recognition site; other site 65393011221 dimerization interface [polypeptide binding]; other site 65393011222 Response regulator receiver domain; Region: Response_reg; pfam00072 65393011223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011224 active site 65393011225 phosphorylation site [posttranslational modification] 65393011226 intermolecular recognition site; other site 65393011227 dimerization interface [polypeptide binding]; other site 65393011228 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 65393011229 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 65393011230 homotetramer interface [polypeptide binding]; other site 65393011231 FMN binding site [chemical binding]; other site 65393011232 homodimer contacts [polypeptide binding]; other site 65393011233 putative active site [active] 65393011234 putative substrate binding site [chemical binding]; other site 65393011235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393011236 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393011237 Probable transposase; Region: OrfB_IS605; pfam01385 65393011238 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393011239 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 65393011240 RNB domain; Region: RNB; pfam00773 65393011241 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 65393011242 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 65393011243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011244 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 65393011245 GIY-YIG motif/motif A; other site 65393011246 TIR domain; Region: TIR; cl02060 65393011247 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 65393011248 GUN4-like; Region: GUN4; pfam05419 65393011249 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 65393011250 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 65393011251 CHASE2 domain; Region: CHASE2; cl01732 65393011252 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393011253 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393011254 active site 65393011255 ATP binding site [chemical binding]; other site 65393011256 substrate binding site [chemical binding]; other site 65393011257 activation loop (A-loop); other site 65393011258 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 65393011259 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 65393011260 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 65393011261 active site 65393011262 catalytic site [active] 65393011263 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 65393011264 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 65393011265 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 65393011266 catalytic site [active] 65393011267 active site 65393011268 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 65393011269 trehalose synthase; Region: treS_nterm; TIGR02456 65393011270 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 65393011271 active site 65393011272 catalytic site [active] 65393011273 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 65393011274 starch-binding site 2 [chemical binding]; other site 65393011275 starch-binding site 1 [chemical binding]; other site 65393011276 Cupin domain; Region: Cupin_2; cl09118 65393011277 S-layer homology domain; Region: SLH; pfam00395 65393011278 S-layer homology domain; Region: SLH; pfam00395 65393011279 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393011280 Dienelactone hydrolase family; Region: DLH; pfam01738 65393011281 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 65393011282 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393011283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011284 active site 65393011285 phosphorylation site [posttranslational modification] 65393011286 intermolecular recognition site; other site 65393011287 dimerization interface [polypeptide binding]; other site 65393011288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393011289 DNA binding site [nucleotide binding] 65393011290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393011291 dimer interface [polypeptide binding]; other site 65393011292 phosphorylation site [posttranslational modification] 65393011293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393011294 ATP binding site [chemical binding]; other site 65393011295 Mg2+ binding site [ion binding]; other site 65393011296 G-X-G motif; other site 65393011297 Rubrerythrin [Energy production and conversion]; Region: COG1592 65393011298 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 65393011299 binuclear metal center [ion binding]; other site 65393011300 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 65393011301 iron-sulfur cluster [ion binding]; other site 65393011302 [2Fe-2S] cluster binding site [ion binding]; other site 65393011303 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 65393011304 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 65393011305 dimer interface [polypeptide binding]; other site 65393011306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393011307 catalytic residue [active] 65393011308 Ycf46; Provisional; Region: ycf46; CHL00195 65393011309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393011310 Walker A motif; other site 65393011311 ATP binding site [chemical binding]; other site 65393011312 Walker B motif; other site 65393011313 arginine finger; other site 65393011314 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 65393011315 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 65393011316 classical (c) SDRs; Region: SDR_c; cd05233 65393011317 NAD(P) binding site [chemical binding]; other site 65393011318 active site 65393011319 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 65393011320 active site 65393011321 FMN binding site [chemical binding]; other site 65393011322 substrate binding site [chemical binding]; other site 65393011323 putative catalytic residue [active] 65393011324 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 65393011325 phosphate binding site [ion binding]; other site 65393011326 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 65393011327 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 65393011328 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 65393011329 active site 65393011330 nucleophile elbow; other site 65393011331 YcfA-like protein; Region: YcfA; cl00752 65393011332 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 65393011333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393011334 Probable transposase; Region: OrfB_IS605; pfam01385 65393011335 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393011336 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393011337 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 65393011338 catalytic core [active] 65393011339 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 65393011340 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 65393011341 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 65393011342 tartrate dehydrogenase; Provisional; Region: PRK08194 65393011343 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 65393011344 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 65393011345 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 65393011346 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 65393011347 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 65393011348 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 65393011349 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 65393011350 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 65393011351 dimer interface [polypeptide binding]; other site 65393011352 motif 1; other site 65393011353 active site 65393011354 motif 2; other site 65393011355 motif 3; other site 65393011356 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 65393011357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393011358 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 65393011359 PilZ domain; Region: PilZ; cl01260 65393011360 DNA gyrase subunit A; Validated; Region: PRK05560 65393011361 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 65393011362 CAP-like domain; other site 65393011363 active site 65393011364 primary dimer interface [polypeptide binding]; other site 65393011365 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 65393011366 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 65393011367 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 65393011368 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 65393011369 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 65393011370 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 65393011371 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393011372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393011373 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 65393011374 Walker A/P-loop; other site 65393011375 ATP binding site [chemical binding]; other site 65393011376 Q-loop/lid; other site 65393011377 ABC transporter signature motif; other site 65393011378 Walker B; other site 65393011379 D-loop; other site 65393011380 H-loop/switch region; other site 65393011381 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 65393011382 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 65393011383 NTP binding site [chemical binding]; other site 65393011384 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 65393011385 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 65393011386 Walker A/P-loop; other site 65393011387 ATP binding site [chemical binding]; other site 65393011388 Q-loop/lid; other site 65393011389 ABC transporter signature motif; other site 65393011390 Walker B; other site 65393011391 D-loop; other site 65393011392 H-loop/switch region; other site 65393011393 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 65393011394 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 65393011395 Walker A/P-loop; other site 65393011396 ATP binding site [chemical binding]; other site 65393011397 Q-loop/lid; other site 65393011398 ABC transporter signature motif; other site 65393011399 Walker B; other site 65393011400 D-loop; other site 65393011401 H-loop/switch region; other site 65393011402 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 65393011403 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 65393011404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 65393011405 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 65393011406 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 65393011407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393011408 S-adenosylmethionine binding site [chemical binding]; other site 65393011409 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 65393011410 active site 65393011411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393011412 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393011413 active site 65393011414 ATP binding site [chemical binding]; other site 65393011415 substrate binding site [chemical binding]; other site 65393011416 activation loop (A-loop); other site 65393011417 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 65393011418 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 65393011419 putative ligand binding site [chemical binding]; other site 65393011420 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 65393011421 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 65393011422 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 65393011423 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393011424 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393011425 ribose-phosphate pyrophosphokinase; Region: PLN02369 65393011426 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 65393011427 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 65393011428 Catalytic site [active] 65393011429 dihydroorotase; Provisional; Region: PRK07575 65393011430 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 65393011431 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 65393011432 active site 65393011433 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 65393011434 putative active site pocket [active] 65393011435 dimerization interface [polypeptide binding]; other site 65393011436 putative catalytic residue [active] 65393011437 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 65393011438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393011439 ATP binding site [chemical binding]; other site 65393011440 Mg2+ binding site [ion binding]; other site 65393011441 G-X-G motif; other site 65393011442 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 65393011443 Response regulator receiver domain; Region: Response_reg; pfam00072 65393011444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011445 active site 65393011446 phosphorylation site [posttranslational modification] 65393011447 intermolecular recognition site; other site 65393011448 dimerization interface [polypeptide binding]; other site 65393011449 Response regulator receiver domain; Region: Response_reg; pfam00072 65393011450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393011451 active site 65393011452 phosphorylation site [posttranslational modification] 65393011453 intermolecular recognition site; other site 65393011454 dimerization interface [polypeptide binding]; other site 65393011455 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 65393011456 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 65393011457 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393011458 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 65393011459 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 65393011460 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 65393011461 conserved cys residue [active] 65393011462 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 65393011463 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 65393011464 PYR/PP interface [polypeptide binding]; other site 65393011465 dimer interface [polypeptide binding]; other site 65393011466 TPP binding site [chemical binding]; other site 65393011467 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 65393011468 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 65393011469 TPP-binding site [chemical binding]; other site 65393011470 dimer interface [polypeptide binding]; other site 65393011471 S-layer homology domain; Region: SLH; pfam00395 65393011472 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 65393011473 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 65393011474 choline dehydrogenase; Validated; Region: PRK02106 65393011475 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 65393011476 choline dehydrogenase; Region: betA; TIGR01810 65393011477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011478 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 65393011479 EthD protein; Region: EthD; cl06234 65393011480 EthD protein; Region: EthD; cl06234 65393011481 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 65393011482 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 65393011483 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 65393011484 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 65393011485 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 65393011486 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 65393011487 dimerization interface [polypeptide binding]; other site 65393011488 putative active cleft [active] 65393011489 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 65393011490 anti sigma factor interaction site; other site 65393011491 regulatory phosphorylation site [posttranslational modification]; other site 65393011492 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 65393011493 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 65393011494 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 65393011495 catalytic site [active] 65393011496 active site 65393011497 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 65393011498 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 65393011499 active site 65393011500 Ca binding site [ion binding]; other site 65393011501 catalytic site [active] 65393011502 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 65393011503 homotrimer interaction site [polypeptide binding]; other site 65393011504 putative active site [active] 65393011505 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 65393011506 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 65393011507 Ligand Binding Site [chemical binding]; other site 65393011508 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 65393011509 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 65393011510 Ligand Binding Site [chemical binding]; other site 65393011511 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 65393011512 Phosphate-starvation-inducible E; Region: PsiE; cl01264 65393011513 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 65393011514 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 65393011515 Permease family; Region: Xan_ur_permease; cl00967 65393011516 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 65393011517 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393011518 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393011519 active site 65393011520 ATP binding site [chemical binding]; other site 65393011521 substrate binding site [chemical binding]; other site 65393011522 activation loop (A-loop); other site 65393011523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393011524 binding surface 65393011525 TPR motif; other site 65393011526 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 65393011527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393011528 binding surface 65393011529 TPR motif; other site 65393011530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393011531 binding surface 65393011532 TPR motif; other site 65393011533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393011534 binding surface 65393011535 TPR motif; other site 65393011536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393011537 binding surface 65393011538 TPR motif; other site 65393011539 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 65393011540 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 65393011541 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 65393011542 Zn2+ binding site [ion binding]; other site 65393011543 Mg2+ binding site [ion binding]; other site 65393011544 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 65393011545 putative ABC transporter; Region: ycf24; CHL00085 65393011546 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 65393011547 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 65393011548 Walker A/P-loop; other site 65393011549 ATP binding site [chemical binding]; other site 65393011550 Q-loop/lid; other site 65393011551 ABC transporter signature motif; other site 65393011552 Walker B; other site 65393011553 D-loop; other site 65393011554 H-loop/switch region; other site 65393011555 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 65393011556 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 65393011557 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 65393011558 Aminotransferase class-V; Region: Aminotran_5; pfam00266 65393011559 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 65393011560 catalytic residue [active] 65393011561 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393011562 Sulfatase; Region: Sulfatase; cl10460 65393011563 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393011564 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393011565 EamA-like transporter family; Region: EamA; cl01037 65393011566 EamA-like transporter family; Region: EamA; cl01037 65393011567 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 65393011568 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 65393011569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393011570 binding surface 65393011571 TPR motif; other site 65393011572 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393011573 putative active site [active] 65393011574 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 65393011575 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 65393011576 GDP-binding site [chemical binding]; other site 65393011577 ACT binding site; other site 65393011578 IMP binding site; other site 65393011579 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 65393011580 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 65393011581 5S rRNA interface [nucleotide binding]; other site 65393011582 CTC domain interface [polypeptide binding]; other site 65393011583 L16 interface [polypeptide binding]; other site 65393011584 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 65393011585 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 65393011586 putative NAD(P) binding site [chemical binding]; other site 65393011587 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 65393011588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 65393011589 ABC-ATPase subunit interface; other site 65393011590 dimer interface [polypeptide binding]; other site 65393011591 putative PBP binding regions; other site 65393011592 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 65393011593 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 65393011594 substrate binding site [chemical binding]; other site 65393011595 active site 65393011596 catalytic residues [active] 65393011597 heterodimer interface [polypeptide binding]; other site 65393011598 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 65393011599 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 65393011600 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 65393011601 active site 65393011602 metal binding site [ion binding]; metal-binding site 65393011603 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 65393011604 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 65393011605 active site 65393011606 Zn2+ binding site [ion binding]; other site 65393011607 PA14 domain; Region: PA14; cl08459 65393011608 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 65393011609 chorismate binding enzyme; Region: Chorismate_bind; cl10555 65393011610 UbiA prenyltransferase family; Region: UbiA; cl00337 65393011611 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 65393011612 active site 65393011613 putative lithium-binding site [ion binding]; other site 65393011614 substrate binding site [chemical binding]; other site 65393011615 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 65393011616 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 65393011617 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 65393011618 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 65393011619 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 65393011620 putative tRNA-binding site [nucleotide binding]; other site 65393011621 B3/4 domain; Region: B3_4; cl11458 65393011622 tRNA synthetase B5 domain; Region: B5; cl08394 65393011623 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 65393011624 dimer interface [polypeptide binding]; other site 65393011625 motif 1; other site 65393011626 motif 3; other site 65393011627 motif 2; other site 65393011628 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 65393011629 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393011630 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393011631 putative active site [active] 65393011632 glycine dehydrogenase; Provisional; Region: PRK05367 65393011633 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 65393011634 tetramer interface [polypeptide binding]; other site 65393011635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393011636 catalytic residue [active] 65393011637 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 65393011638 tetramer interface [polypeptide binding]; other site 65393011639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393011640 catalytic residue [active] 65393011641 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393011642 putative active site [active] 65393011643 Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527 65393011644 Protein-arginine deiminase (PAD); Region: PAD; pfam03068 65393011645 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393011646 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393011647 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 65393011648 GUN4-like; Region: GUN4; pfam05419 65393011649 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 65393011650 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 65393011651 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 65393011652 Uncharacterized conserved protein [Function unknown]; Region: COG2308 65393011653 Domain of unknown function (DUF404); Region: DUF404; pfam04169 65393011654 Domain of unknown function (DUF407); Region: DUF407; pfam04174 65393011655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393011656 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393011657 Probable transposase; Region: OrfB_IS605; pfam01385 65393011658 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393011659 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 65393011660 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 65393011661 RNA binding surface [nucleotide binding]; other site 65393011662 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 65393011663 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 65393011664 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 65393011665 DXD motif; other site 65393011666 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 65393011667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011668 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 65393011669 putative L-serine binding site [chemical binding]; other site 65393011670 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 65393011671 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 65393011672 active site 65393011673 TDP-binding site; other site 65393011674 acceptor substrate-binding pocket; other site 65393011675 homodimer interface [polypeptide binding]; other site 65393011676 DAK2 domain; Region: Dak2; cl03685 65393011677 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 65393011678 Dak1 domain; Region: Dak1; pfam02733 65393011679 aspartate aminotransferase; Provisional; Region: PRK05764 65393011680 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 65393011681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393011682 homodimer interface [polypeptide binding]; other site 65393011683 catalytic residue [active] 65393011684 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393011685 Ligand Binding Site [chemical binding]; other site 65393011686 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 65393011687 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393011688 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393011689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393011690 Predicted membrane protein [Function unknown]; Region: COG4327; cl01781 65393011691 Sodium:solute symporter family; Region: SSF; cl00456 65393011692 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 65393011693 TIR domain; Region: TIR; cl02060 65393011694 TIR domain; Region: TIR; cl02060 65393011695 TIR domain; Region: TIR; cl02060 65393011696 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393011697 structural tetrad; other site 65393011698 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393011699 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393011700 structural tetrad; other site 65393011701 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 65393011702 amino-acid N-acetyltransferase; Region: N-Ac-Glu-synth; TIGR01890 65393011703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393011704 Coenzyme A binding pocket [chemical binding]; other site 65393011705 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 65393011706 hypothetical protein; Reviewed; Region: PRK09588 65393011707 Archease protein family (DUF101/UPF0211); Region: Archease; cl00606 65393011708 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 65393011709 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 65393011710 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 65393011711 ligand binding site [chemical binding]; other site 65393011712 flexible hinge region; other site 65393011713 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 65393011714 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 65393011715 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 65393011716 protein binding site [polypeptide binding]; other site 65393011717 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 65393011718 homodimer interface [polypeptide binding]; other site 65393011719 substrate-cofactor binding pocket; other site 65393011720 Aminotransferase class IV; Region: Aminotran_4; pfam01063 65393011721 catalytic residue [active] 65393011722 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 65393011723 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 65393011724 dimer interface [polypeptide binding]; other site 65393011725 glycine-pyridoxal phosphate binding site [chemical binding]; other site 65393011726 active site 65393011727 folate binding site [chemical binding]; other site 65393011728 Chloroplast import component protein (Tic20); Region: Tic20; cl09892 65393011729 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 65393011730 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 65393011731 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 65393011732 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 65393011733 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 65393011734 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 65393011735 protein binding site [polypeptide binding]; other site 65393011736 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 65393011737 Domain interface; other site 65393011738 Peptide binding site; other site 65393011739 Active site tetrad [active] 65393011740 phosphate acetyltransferase; Reviewed; Region: PRK05632 65393011741 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393011742 DRTGG domain; Region: DRTGG; cl12147 65393011743 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 65393011744 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474 65393011745 Predicted RNA interaction site [nucleotide binding]; other site 65393011746 putative binding site; other site 65393011747 Mutations affecting start-site selection; other site 65393011748 Phycobilisome protein; Region: Phycobilisome; cl08227 65393011749 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 65393011750 nucleophile elbow; other site 65393011751 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 65393011752 FtsH Extracellular; Region: FtsH_ext; pfam06480 65393011753 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 65393011754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393011755 Walker A motif; other site 65393011756 ATP binding site [chemical binding]; other site 65393011757 Walker B motif; other site 65393011758 arginine finger; other site 65393011759 Peptidase family M41; Region: Peptidase_M41; pfam01434 65393011760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 65393011761 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 65393011762 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 65393011763 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 65393011764 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 65393011765 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 65393011766 putative dimer interface [polypeptide binding]; other site 65393011767 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393011768 Helix-turn-helix domains; Region: HTH; cl00088 65393011769 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 65393011770 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 65393011771 active site residue [active] 65393011772 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 65393011773 Flavoprotein; Region: Flavoprotein; cl08021 65393011774 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 65393011775 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 65393011776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 65393011777 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393011778 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 65393011779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 65393011780 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 65393011781 synthetase active site [active] 65393011782 NTP binding site [chemical binding]; other site 65393011783 metal binding site [ion binding]; metal-binding site 65393011784 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 65393011785 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 65393011786 DGQHR domain; Region: DGQHR; cl14002 65393011787 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 65393011788 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393011789 active site 65393011790 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393011791 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 65393011792 EamA-like transporter family; Region: EamA; cl01037 65393011793 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 65393011794 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 65393011795 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 65393011796 substrate-cofactor binding pocket; other site 65393011797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393011798 catalytic residue [active] 65393011799 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 65393011800 DGQHR domain; Region: DGQHR; cl14002 65393011801 DGQHR domain; Region: DGQHR; cl14002 65393011802 Uncharacterized conserved protein [Function unknown]; Region: COG5464 65393011803 DGQHR domain; Region: DGQHR; cl14002 65393011804 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 65393011805 Active Sites [active] 65393011806 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 65393011807 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 65393011808 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 65393011809 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393011810 Walker A/P-loop; other site 65393011811 ATP binding site [chemical binding]; other site 65393011812 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 65393011813 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393011814 ABC transporter signature motif; other site 65393011815 Walker B; other site 65393011816 D-loop; other site 65393011817 H-loop/switch region; other site 65393011818 GUN4-like; Region: GUN4; pfam05419 65393011819 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 65393011820 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 65393011821 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 65393011822 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 65393011823 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393011824 Phage integrase family; Region: Phage_integrase; pfam00589 65393011825 DNA binding site [nucleotide binding] 65393011826 Int/Topo IB signature motif; other site 65393011827 active site 65393011828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 65393011829 dimerization interface [polypeptide binding]; other site 65393011830 putative DNA binding site [nucleotide binding]; other site 65393011831 putative Zn2+ binding site [ion binding]; other site 65393011832 Domain of unknown function DUF20; Region: UPF0118; cl00465 65393011833 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 65393011834 GUN4-like; Region: GUN4; pfam05419 65393011835 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 65393011836 classical (c) SDRs; Region: SDR_c; cd05233 65393011837 NAD(P) binding site [chemical binding]; other site 65393011838 active site 65393011839 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 65393011840 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 65393011841 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 65393011842 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 65393011843 Clp amino terminal domain; Region: Clp_N; pfam02861 65393011844 Clp amino terminal domain; Region: Clp_N; pfam02861 65393011845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393011846 Walker A motif; other site 65393011847 ATP binding site [chemical binding]; other site 65393011848 Walker B motif; other site 65393011849 arginine finger; other site 65393011850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393011851 Walker A motif; other site 65393011852 ATP binding site [chemical binding]; other site 65393011853 Walker B motif; other site 65393011854 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 65393011855 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 65393011856 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393011857 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 65393011858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011859 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 65393011860 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 65393011861 iron-sulfur cluster [ion binding]; other site 65393011862 [2Fe-2S] cluster binding site [ion binding]; other site 65393011863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011864 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 65393011865 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393011866 phosphopeptide binding site; other site 65393011867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393011868 metal binding site [ion binding]; metal-binding site 65393011869 active site 65393011870 I-site; other site 65393011871 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393011872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393011873 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 65393011874 Walker A/P-loop; other site 65393011875 ATP binding site [chemical binding]; other site 65393011876 Q-loop/lid; other site 65393011877 ABC transporter signature motif; other site 65393011878 Walker B; other site 65393011879 D-loop; other site 65393011880 H-loop/switch region; other site 65393011881 ABC-2 type transporter; Region: ABC2_membrane; cl11417 65393011882 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 65393011883 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393011884 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 65393011885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011886 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 65393011887 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 65393011888 dimer interface [polypeptide binding]; other site 65393011889 PYR/PP interface [polypeptide binding]; other site 65393011890 TPP binding site [chemical binding]; other site 65393011891 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 65393011892 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 65393011893 TPP-binding site [chemical binding]; other site 65393011894 dimer interface [polypeptide binding]; other site 65393011895 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 65393011896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393011897 Coenzyme A binding pocket [chemical binding]; other site 65393011898 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 65393011899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393011900 NAD(P) binding site [chemical binding]; other site 65393011901 active site 65393011902 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 65393011903 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 65393011904 TM-ABC transporter signature motif; other site 65393011905 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 65393011906 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 65393011907 Walker A/P-loop; other site 65393011908 ATP binding site [chemical binding]; other site 65393011909 Q-loop/lid; other site 65393011910 ABC transporter signature motif; other site 65393011911 Walker B; other site 65393011912 D-loop; other site 65393011913 H-loop/switch region; other site 65393011914 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 65393011915 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 65393011916 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 65393011917 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393011918 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 65393011919 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393011920 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 65393011921 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 65393011922 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 65393011923 ATP-binding site [chemical binding]; other site 65393011924 Gluconate-6-phosphate binding site [chemical binding]; other site 65393011925 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 65393011926 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393011927 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 65393011928 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 65393011929 Integral membrane protein DUF92; Region: DUF92; cl00793 65393011930 GAF domain; Region: GAF; cl00853 65393011931 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 65393011932 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 65393011933 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 65393011934 generic binding surface I; other site 65393011935 generic binding surface II; other site 65393011936 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 65393011937 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 65393011938 Walker A/P-loop; other site 65393011939 ATP binding site [chemical binding]; other site 65393011940 Q-loop/lid; other site 65393011941 ABC transporter signature motif; other site 65393011942 Walker B; other site 65393011943 D-loop; other site 65393011944 H-loop/switch region; other site 65393011945 Smr domain; Region: Smr; cl02619 65393011946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393011947 binding surface 65393011948 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 65393011949 TPR motif; other site 65393011950 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 65393011951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 65393011952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393011953 DNA binding residues [nucleotide binding] 65393011954 dimerization interface [polypeptide binding]; other site 65393011955 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 65393011956 metal ion-dependent adhesion site (MIDAS); other site 65393011957 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 65393011958 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393011959 active site 65393011960 NTP binding site [chemical binding]; other site 65393011961 metal binding triad [ion binding]; metal-binding site 65393011962 antibiotic binding site [chemical binding]; other site 65393011963 Protein of unknown function DUF86; Region: DUF86; cl01031 65393011964 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 65393011965 Leucine-rich repeats; other site 65393011966 Substrate binding site [chemical binding]; other site 65393011967 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 65393011968 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cd00882 65393011969 G1 box; other site 65393011970 GTP/Mg2+ binding site [chemical binding]; other site 65393011971 G2 box; other site 65393011972 Switch I region; other site 65393011973 G3 box; other site 65393011974 Switch II region; other site 65393011975 G4 box; other site 65393011976 TIR domain; Region: TIR; cl02060 65393011977 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 65393011978 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 65393011979 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 65393011980 Active_site [active] 65393011981 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393011982 Protein of unknown function (DUF423); Region: DUF423; cl01008 65393011983 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 65393011984 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 65393011985 NAD binding site [chemical binding]; other site 65393011986 substrate binding site [chemical binding]; other site 65393011987 active site 65393011988 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393011989 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 65393011990 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393011991 putative active site [active] 65393011992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393011993 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393011994 Probable transposase; Region: OrfB_IS605; pfam01385 65393011995 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393011996 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 65393011997 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 65393011998 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 65393011999 dimerization domain swap beta strand [polypeptide binding]; other site 65393012000 regulatory protein interface [polypeptide binding]; other site 65393012001 active site 65393012002 regulatory phosphorylation site [posttranslational modification]; other site 65393012003 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 65393012004 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 65393012005 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 65393012006 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 65393012007 EamA-like transporter family; Region: EamA; cl01037 65393012008 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 65393012009 catalytic motif [active] 65393012010 Catalytic residue [active] 65393012011 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 65393012012 catalytic motif [active] 65393012013 Catalytic residue [active] 65393012014 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 65393012015 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 65393012016 LytB protein; Region: LYTB; cl00507 65393012017 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 65393012018 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393012019 FOG: CBS domain [General function prediction only]; Region: COG0517 65393012020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 65393012021 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 65393012022 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393012023 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393012024 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393012025 DNA binding residues [nucleotide binding] 65393012026 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 65393012027 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 65393012028 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 65393012029 active site 65393012030 substrate binding site [chemical binding]; other site 65393012031 metal binding site [ion binding]; metal-binding site 65393012032 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 65393012033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393012034 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 65393012035 BON domain; Region: BON; cl02771 65393012036 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 65393012037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393012038 TPR motif; other site 65393012039 binding surface 65393012040 PAS fold; Region: PAS_4; pfam08448 65393012041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393012042 putative active site [active] 65393012043 heme pocket [chemical binding]; other site 65393012044 PAS domain S-box; Region: sensory_box; TIGR00229 65393012045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393012046 PAS domain S-box; Region: sensory_box; TIGR00229 65393012047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393012048 putative active site [active] 65393012049 heme pocket [chemical binding]; other site 65393012050 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393012051 metal binding site [ion binding]; metal-binding site 65393012052 active site 65393012053 I-site; other site 65393012054 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393012055 mercuric reductase; Validated; Region: PRK06370 65393012056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393012057 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 65393012058 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 65393012059 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 65393012060 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 65393012061 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 65393012062 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 65393012063 RNA binding site [nucleotide binding]; other site 65393012064 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 65393012065 Predicted permease; Region: DUF318; cl00487 65393012066 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 65393012067 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 65393012068 transmembrane helices; other site 65393012069 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 65393012070 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 65393012071 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 65393012072 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 65393012073 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 65393012074 transmembrane helices; other site 65393012075 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 65393012076 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 65393012077 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 65393012078 catalytic residues [active] 65393012079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 65393012080 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 65393012081 dimer interface [polypeptide binding]; other site 65393012082 active site 65393012083 metal binding site [ion binding]; metal-binding site 65393012084 glutathione binding site [chemical binding]; other site 65393012085 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 65393012086 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 65393012087 active site clefts [active] 65393012088 zinc binding site [ion binding]; other site 65393012089 dimer interface [polypeptide binding]; other site 65393012090 Domain of unknown function DUF21; Region: DUF21; pfam01595 65393012091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 65393012092 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 65393012093 proposed catalytic triad [active] 65393012094 active site nucleophile [active] 65393012095 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 65393012096 O-Antigen ligase; Region: Wzy_C; cl04850 65393012097 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393012098 GAF domain; Region: GAF; cl00853 65393012099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 65393012100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012101 dimer interface [polypeptide binding]; other site 65393012102 phosphorylation site [posttranslational modification] 65393012103 GUN4-like; Region: GUN4; pfam05419 65393012104 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 65393012105 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 65393012106 active site 65393012107 nucleotide binding site [chemical binding]; other site 65393012108 HIGH motif; other site 65393012109 KMSKS motif; other site 65393012110 spermine synthase; Region: PLN02823 65393012111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393012112 S-adenosylmethionine binding site [chemical binding]; other site 65393012113 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 65393012114 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 65393012115 cofactor binding site; other site 65393012116 DNA binding site [nucleotide binding] 65393012117 substrate interaction site [chemical binding]; other site 65393012118 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 65393012119 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 65393012120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393012121 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 65393012122 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 65393012123 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 65393012124 putative ligand binding site [chemical binding]; other site 65393012125 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393012126 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393012127 active site 65393012128 ATP binding site [chemical binding]; other site 65393012129 substrate binding site [chemical binding]; other site 65393012130 activation loop (A-loop); other site 65393012131 short chain dehydrogenase; Provisional; Region: PRK06197 65393012132 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 65393012133 putative NAD(P) binding site [chemical binding]; other site 65393012134 active site 65393012135 biotin synthase; Region: bioB; TIGR00433 65393012136 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 65393012137 FeS/SAM binding site; other site 65393012138 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 65393012139 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 65393012140 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 65393012141 lipoprotein signal peptidase; Provisional; Region: PRK14787 65393012142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393012143 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 65393012144 active site 65393012145 putative substrate binding region [chemical binding]; other site 65393012146 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 65393012147 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 65393012148 putative active site [active] 65393012149 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 65393012150 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 65393012151 photosystem I subunit VII; Region: psaC; CHL00065 65393012152 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 65393012153 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 65393012154 active site 65393012155 NAD binding site [chemical binding]; other site 65393012156 metal binding site [ion binding]; metal-binding site 65393012157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393012158 S-adenosylmethionine binding site [chemical binding]; other site 65393012159 hypothetical protein; Provisional; Region: PRK06849 65393012160 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393012161 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393012162 Sodium:solute symporter family; Region: SSF; cl00456 65393012163 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 65393012164 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393012165 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393012166 proline/glycine betaine transporter; Provisional; Region: PRK10642 65393012167 TIR domain; Region: TIR; cl02060 65393012168 GUN4-like; Region: GUN4; pfam05419 65393012169 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 65393012170 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 65393012171 PYR/PP interface [polypeptide binding]; other site 65393012172 dimer interface [polypeptide binding]; other site 65393012173 TPP binding site [chemical binding]; other site 65393012174 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 65393012175 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 65393012176 TPP-binding site [chemical binding]; other site 65393012177 dimer interface [polypeptide binding]; other site 65393012178 CpeS-like protein; Region: CpeS; pfam09367 65393012179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393012180 PAS fold; Region: PAS_3; pfam08447 65393012181 putative active site [active] 65393012182 heme pocket [chemical binding]; other site 65393012183 PAS domain S-box; Region: sensory_box; TIGR00229 65393012184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393012185 putative active site [active] 65393012186 heme pocket [chemical binding]; other site 65393012187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393012188 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 65393012189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393012190 putative active site [active] 65393012191 heme pocket [chemical binding]; other site 65393012192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012193 dimer interface [polypeptide binding]; other site 65393012194 phosphorylation site [posttranslational modification] 65393012195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012196 ATP binding site [chemical binding]; other site 65393012197 Mg2+ binding site [ion binding]; other site 65393012198 G-X-G motif; other site 65393012199 Response regulator receiver domain; Region: Response_reg; pfam00072 65393012200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012201 active site 65393012202 phosphorylation site [posttranslational modification] 65393012203 intermolecular recognition site; other site 65393012204 dimerization interface [polypeptide binding]; other site 65393012205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 65393012206 dimer interface [polypeptide binding]; other site 65393012207 conserved gate region; other site 65393012208 putative PBP binding loops; other site 65393012209 ABC-ATPase subunit interface; other site 65393012210 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393012211 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 65393012212 Walker A/P-loop; other site 65393012213 ATP binding site [chemical binding]; other site 65393012214 Q-loop/lid; other site 65393012215 ABC transporter signature motif; other site 65393012216 Walker B; other site 65393012217 D-loop; other site 65393012218 H-loop/switch region; other site 65393012219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 65393012220 TOBE domain; Region: TOBE_2; cl01440 65393012221 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 65393012222 LysE type translocator; Region: LysE; cl00565 65393012223 ResB-like family; Region: ResB; pfam05140 65393012224 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 65393012225 general secretion pathway protein J; Region: gspJ; TIGR01711 65393012226 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 65393012227 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 65393012228 CHASE2 domain; Region: CHASE2; cl01732 65393012229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 65393012230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012231 ATP binding site [chemical binding]; other site 65393012232 Mg2+ binding site [ion binding]; other site 65393012233 G-X-G motif; other site 65393012234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012235 active site 65393012236 phosphorylation site [posttranslational modification] 65393012237 intermolecular recognition site; other site 65393012238 dimerization interface [polypeptide binding]; other site 65393012239 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 65393012240 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 65393012241 dimer interface [polypeptide binding]; other site 65393012242 motif 1; other site 65393012243 active site 65393012244 motif 2; other site 65393012245 motif 3; other site 65393012246 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 65393012247 anticodon binding site; other site 65393012248 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 65393012249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012250 dimer interface [polypeptide binding]; other site 65393012251 phosphorylation site [posttranslational modification] 65393012252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012253 ATP binding site [chemical binding]; other site 65393012254 G-X-G motif; other site 65393012255 Response regulator receiver domain; Region: Response_reg; pfam00072 65393012256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012257 active site 65393012258 phosphorylation site [posttranslational modification] 65393012259 intermolecular recognition site; other site 65393012260 dimerization interface [polypeptide binding]; other site 65393012261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012262 dimer interface [polypeptide binding]; other site 65393012263 phosphorylation site [posttranslational modification] 65393012264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012265 ATP binding site [chemical binding]; other site 65393012266 Mg2+ binding site [ion binding]; other site 65393012267 G-X-G motif; other site 65393012268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393012269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012270 active site 65393012271 phosphorylation site [posttranslational modification] 65393012272 intermolecular recognition site; other site 65393012273 dimerization interface [polypeptide binding]; other site 65393012274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393012275 DNA binding site [nucleotide binding] 65393012276 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 65393012277 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 65393012278 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 65393012279 dimer interface [polypeptide binding]; other site 65393012280 substrate binding site [chemical binding]; other site 65393012281 ATP binding site [chemical binding]; other site 65393012282 cell division protein FtsZ; Validated; Region: PRK09330 65393012283 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 65393012284 nucleotide binding site [chemical binding]; other site 65393012285 SulA interaction site; other site 65393012286 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 65393012287 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 65393012288 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 65393012289 C-terminal peptidase (prc); Region: prc; TIGR00225 65393012290 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 65393012291 protein binding site [polypeptide binding]; other site 65393012292 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 65393012293 Catalytic dyad [active] 65393012294 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 65393012295 tetramer interface [polypeptide binding]; other site 65393012296 dimer interface [polypeptide binding]; other site 65393012297 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 65393012298 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 65393012299 Walker A motif; other site 65393012300 ATP binding site [chemical binding]; other site 65393012301 Walker B motif; other site 65393012302 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 65393012303 homodimer interface [polypeptide binding]; other site 65393012304 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 65393012305 active site pocket [active] 65393012306 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 65393012307 OstA-like protein; Region: OstA; cl00844 65393012308 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 65393012309 calcium/proton exchanger (cax); Region: cax; TIGR00378 65393012310 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 65393012311 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 65393012312 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 65393012313 active site 65393012314 putative substrate binding region [chemical binding]; other site 65393012315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 65393012316 Double zinc ribbon; Region: DZR; pfam12773 65393012317 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 65393012318 phosphopeptide binding site; other site 65393012319 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 65393012320 putative active site [active] 65393012321 Protein of unknown function (DUF502); Region: DUF502; cl01107 65393012322 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 65393012323 putative RNA binding site [nucleotide binding]; other site 65393012324 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 65393012325 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 65393012326 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 65393012327 P loop; other site 65393012328 GTP binding site [chemical binding]; other site 65393012329 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 65393012330 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 65393012331 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393012332 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 65393012333 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 65393012334 active site 65393012335 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 65393012336 catalytic triad [active] 65393012337 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 65393012338 Protein of unknown function (DUF497); Region: DUF497; cl01108 65393012339 Protein of unknown function (DUF497); Region: DUF497; cl01108 65393012340 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 65393012341 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 65393012342 HIGH motif; other site 65393012343 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 65393012344 active site 65393012345 KMSKS motif; other site 65393012346 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 65393012347 tRNA binding surface [nucleotide binding]; other site 65393012348 anticodon binding site; other site 65393012349 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 65393012350 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393012351 putative active site [active] 65393012352 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 65393012353 Walker A/P-loop; other site 65393012354 ATP binding site [chemical binding]; other site 65393012355 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 65393012356 Precorrin-8X methylmutase; Region: CbiC; pfam02570 65393012357 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 65393012358 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 65393012359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393012360 S-adenosylmethionine binding site [chemical binding]; other site 65393012361 adaptive-response sensory kinase; Validated; Region: PRK09303 65393012362 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 65393012363 tetramer interface [polypeptide binding]; other site 65393012364 dimer interface [polypeptide binding]; other site 65393012365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012366 dimer interface [polypeptide binding]; other site 65393012367 phosphorylation site [posttranslational modification] 65393012368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012369 ATP binding site [chemical binding]; other site 65393012370 Mg2+ binding site [ion binding]; other site 65393012371 G-X-G motif; other site 65393012372 Uncharacterized conserved protein [Function unknown]; Region: COG1543 65393012373 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 65393012374 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 65393012375 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 65393012376 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 65393012377 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393012378 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 65393012379 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 65393012380 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 65393012381 Haemolysin XhlA; Region: XhlA; pfam10779 65393012382 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 65393012383 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393012384 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 65393012385 MASE1; Region: MASE1; pfam05231 65393012386 GAF domain; Region: GAF; cl00853 65393012387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 65393012388 dimer interface [polypeptide binding]; other site 65393012389 phosphorylation site [posttranslational modification] 65393012390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012391 ATP binding site [chemical binding]; other site 65393012392 Mg2+ binding site [ion binding]; other site 65393012393 G-X-G motif; other site 65393012394 Response regulator receiver domain; Region: Response_reg; pfam00072 65393012395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012396 active site 65393012397 phosphorylation site [posttranslational modification] 65393012398 intermolecular recognition site; other site 65393012399 dimerization interface [polypeptide binding]; other site 65393012400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393012401 DNA binding residues [nucleotide binding] 65393012402 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 65393012403 nucleoside/Zn binding site; other site 65393012404 dimer interface [polypeptide binding]; other site 65393012405 catalytic motif [active] 65393012406 ATP phosphoribosyltransferase; Region: HisG; cl15266 65393012407 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 65393012408 short chain dehydrogenase; Provisional; Region: PRK07109 65393012409 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 65393012410 putative NAD(P) binding site [chemical binding]; other site 65393012411 active site 65393012412 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 65393012413 putative diguanylate cyclase; Provisional; Region: PRK09776 65393012414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393012415 putative active site [active] 65393012416 heme pocket [chemical binding]; other site 65393012417 sensory histidine kinase AtoS; Provisional; Region: PRK11360 65393012418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012419 dimer interface [polypeptide binding]; other site 65393012420 phosphorylation site [posttranslational modification] 65393012421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012422 ATP binding site [chemical binding]; other site 65393012423 Mg2+ binding site [ion binding]; other site 65393012424 G-X-G motif; other site 65393012425 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 65393012426 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 65393012427 Domain of unknown function (DUF205); Region: DUF205; cl00410 65393012428 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 65393012429 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 65393012430 carboxyltransferase (CT) interaction site; other site 65393012431 biotinylation site [posttranslational modification]; other site 65393012432 elongation factor P; Validated; Region: PRK00529 65393012433 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 65393012434 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 65393012435 RNA binding site [nucleotide binding]; other site 65393012436 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 65393012437 RNA binding site [nucleotide binding]; other site 65393012438 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 65393012439 active site 65393012440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012441 active site 65393012442 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 65393012443 phosphorylation site [posttranslational modification] 65393012444 intermolecular recognition site; other site 65393012445 dimerization interface [polypeptide binding]; other site 65393012446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393012447 metal binding site [ion binding]; metal-binding site 65393012448 active site 65393012449 I-site; other site 65393012450 Cache domain; Region: Cache_1; pfam02743 65393012451 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 65393012452 dimerization interface [polypeptide binding]; other site 65393012453 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 65393012454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393012455 putative active site [active] 65393012456 heme pocket [chemical binding]; other site 65393012457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012458 dimer interface [polypeptide binding]; other site 65393012459 phosphorylation site [posttranslational modification] 65393012460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012461 ATP binding site [chemical binding]; other site 65393012462 Mg2+ binding site [ion binding]; other site 65393012463 G-X-G motif; other site 65393012464 Response regulator receiver domain; Region: Response_reg; pfam00072 65393012465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012466 active site 65393012467 phosphorylation site [posttranslational modification] 65393012468 intermolecular recognition site; other site 65393012469 dimerization interface [polypeptide binding]; other site 65393012470 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793 65393012471 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 65393012472 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 65393012473 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 65393012474 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 65393012475 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 65393012476 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 65393012477 alpha subunit interaction interface [polypeptide binding]; other site 65393012478 Walker A motif; other site 65393012479 ATP binding site [chemical binding]; other site 65393012480 Walker B motif; other site 65393012481 inhibitor binding site; inhibition site 65393012482 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 65393012483 Protein required for attachment to host cells; Region: Host_attach; cl02398 65393012484 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 65393012485 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 65393012486 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 65393012487 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 65393012488 homodimer interface [polypeptide binding]; other site 65393012489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393012490 catalytic residue [active] 65393012491 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393012492 Ligand Binding Site [chemical binding]; other site 65393012493 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 65393012494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 65393012495 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393012496 putative active site [active] 65393012497 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 65393012498 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 65393012499 DNA binding site [nucleotide binding] 65393012500 catalytic residue [active] 65393012501 H2TH interface [polypeptide binding]; other site 65393012502 putative catalytic residues [active] 65393012503 turnover-facilitating residue; other site 65393012504 intercalation triad [nucleotide binding]; other site 65393012505 8OG recognition residue [nucleotide binding]; other site 65393012506 putative reading head residues; other site 65393012507 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 65393012508 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 65393012509 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 65393012510 Connector enhancer of kinase suppressor of ras; Region: CRIC_ras_sig; pfam10534 65393012511 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393012512 putative active site [active] 65393012513 DNA primase; Validated; Region: dnaG; PRK05667 65393012514 CHC2 zinc finger; Region: zf-CHC2; cl15369 65393012515 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 65393012516 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 65393012517 active site 65393012518 metal binding site [ion binding]; metal-binding site 65393012519 interdomain interaction site; other site 65393012520 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 65393012521 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 65393012522 catalytic residues [active] 65393012523 GUN4-like; Region: GUN4; pfam05419 65393012524 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 65393012525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012526 active site 65393012527 phosphorylation site [posttranslational modification] 65393012528 intermolecular recognition site; other site 65393012529 dimerization interface [polypeptide binding]; other site 65393012530 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393012531 GAF domain; Region: GAF; cl00853 65393012532 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393012533 metal binding site [ion binding]; metal-binding site 65393012534 active site 65393012535 I-site; other site 65393012536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393012537 PAS fold; Region: PAS_3; pfam08447 65393012538 putative active site [active] 65393012539 heme pocket [chemical binding]; other site 65393012540 PAS domain S-box; Region: sensory_box; TIGR00229 65393012541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 65393012542 PAS fold; Region: PAS_4; pfam08448 65393012543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393012544 putative active site [active] 65393012545 heme pocket [chemical binding]; other site 65393012546 PAS fold; Region: PAS_4; pfam08448 65393012547 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393012548 GAF domain; Region: GAF; cl00853 65393012549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012550 dimer interface [polypeptide binding]; other site 65393012551 phosphorylation site [posttranslational modification] 65393012552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012553 ATP binding site [chemical binding]; other site 65393012554 Mg2+ binding site [ion binding]; other site 65393012555 G-X-G motif; other site 65393012556 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 65393012557 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 65393012558 RNA binding site [nucleotide binding]; other site 65393012559 active site 65393012560 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 65393012561 RNA/DNA hybrid binding site [nucleotide binding]; other site 65393012562 active site 65393012563 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 65393012564 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393012565 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 65393012566 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 65393012567 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 65393012568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393012569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393012570 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 65393012571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393012572 binding surface 65393012573 TPR motif; other site 65393012574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393012575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393012576 binding surface 65393012577 TPR motif; other site 65393012578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393012579 binding surface 65393012580 TPR motif; other site 65393012581 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 65393012582 DctM-like transporters; Region: DctM; pfam06808 65393012583 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 65393012584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 65393012585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012586 dimer interface [polypeptide binding]; other site 65393012587 phosphorylation site [posttranslational modification] 65393012588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012589 ATP binding site [chemical binding]; other site 65393012590 Mg2+ binding site [ion binding]; other site 65393012591 G-X-G motif; other site 65393012592 Response regulator receiver domain; Region: Response_reg; pfam00072 65393012593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012594 active site 65393012595 phosphorylation site [posttranslational modification] 65393012596 intermolecular recognition site; other site 65393012597 dimerization interface [polypeptide binding]; other site 65393012598 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 65393012599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012600 active site 65393012601 phosphorylation site [posttranslational modification] 65393012602 intermolecular recognition site; other site 65393012603 dimerization interface [polypeptide binding]; other site 65393012604 GAF domain; Region: GAF; cl00853 65393012605 PAS domain S-box; Region: sensory_box; TIGR00229 65393012606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 65393012607 putative active site [active] 65393012608 heme pocket [chemical binding]; other site 65393012609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393012610 metal binding site [ion binding]; metal-binding site 65393012611 active site 65393012612 I-site; other site 65393012613 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393012614 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393012615 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 65393012616 active site 65393012617 metal binding site [ion binding]; metal-binding site 65393012618 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 65393012619 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 65393012620 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 65393012621 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 65393012622 putative active site [active] 65393012623 catalytic site [active] 65393012624 putative substrate binding site [chemical binding]; other site 65393012625 DNA translocase FtsK; Provisional; Region: PRK10263 65393012626 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393012627 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 65393012628 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 65393012629 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 65393012630 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 65393012631 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 65393012632 Late competence development protein ComFB; Region: ComFB; pfam10719 65393012633 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 65393012634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393012635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393012636 DNA binding residues [nucleotide binding] 65393012637 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 65393012638 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 65393012639 putative active site pocket [active] 65393012640 dimerization interface [polypeptide binding]; other site 65393012641 putative catalytic residue [active] 65393012642 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 65393012643 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 65393012644 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 65393012645 N- and C-terminal domain interface [polypeptide binding]; other site 65393012646 active site 65393012647 MgATP binding site [chemical binding]; other site 65393012648 catalytic site [active] 65393012649 metal binding site [ion binding]; metal-binding site 65393012650 carbohydrate binding site [chemical binding]; other site 65393012651 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 65393012652 nudix motif; other site 65393012653 Ion channel; Region: Ion_trans_2; cl11596 65393012654 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 65393012655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393012656 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 65393012657 acetylornithine aminotransferase; Provisional; Region: PRK02627 65393012658 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 65393012659 inhibitor-cofactor binding pocket; inhibition site 65393012660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393012661 catalytic residue [active] 65393012662 Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549 65393012663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393012664 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 65393012665 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 65393012666 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 65393012667 Cytochrome P450; Region: p450; cl12078 65393012668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393012669 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393012670 Probable transposase; Region: OrfB_IS605; pfam01385 65393012671 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393012672 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 65393012673 Ycf39; Provisional; Region: ycf39; CHL00194 65393012674 NAD(P) binding site [chemical binding]; other site 65393012675 putative active site [active] 65393012676 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 65393012677 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 65393012678 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 65393012679 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 65393012680 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 65393012681 Double zinc ribbon; Region: DZR; pfam12773 65393012682 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 65393012683 apolar tunnel; other site 65393012684 heme binding site [chemical binding]; other site 65393012685 dimerization interface [polypeptide binding]; other site 65393012686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 65393012687 Transposase; Region: DDE_Tnp_ISL3; pfam01610 65393012688 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 65393012689 metal ion-dependent adhesion site (MIDAS); other site 65393012690 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 65393012691 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 65393012692 putative ligand binding site [chemical binding]; other site 65393012693 Iron permease FTR1 family; Region: FTR1; cl00475 65393012694 Ferritin-like domain; Region: Ferritin; pfam00210 65393012695 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 65393012696 dinuclear metal binding motif [ion binding]; other site 65393012697 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 65393012698 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 65393012699 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 65393012700 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 65393012701 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393012702 putative active site [active] 65393012703 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 65393012704 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 65393012705 tRNA; other site 65393012706 putative tRNA binding site [nucleotide binding]; other site 65393012707 putative NADP binding site [chemical binding]; other site 65393012708 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 65393012709 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 65393012710 putative active site [active] 65393012711 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 65393012712 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 65393012713 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 65393012714 dimerization interface [polypeptide binding]; other site 65393012715 domain crossover interface; other site 65393012716 redox-dependent activation switch; other site 65393012717 Mechanosensitive ion channel; Region: MS_channel; pfam00924 65393012718 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 65393012719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012720 active site 65393012721 phosphorylation site [posttranslational modification] 65393012722 intermolecular recognition site; other site 65393012723 dimerization interface [polypeptide binding]; other site 65393012724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 65393012725 DNA binding site [nucleotide binding] 65393012726 CHASE3 domain; Region: CHASE3; cl05000 65393012727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012728 dimer interface [polypeptide binding]; other site 65393012729 phosphorylation site [posttranslational modification] 65393012730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012731 ATP binding site [chemical binding]; other site 65393012732 Mg2+ binding site [ion binding]; other site 65393012733 G-X-G motif; other site 65393012734 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 65393012735 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 65393012736 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 65393012737 active site 65393012738 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 65393012739 active site 65393012740 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 65393012741 protein binding site [polypeptide binding]; other site 65393012742 zinc metallopeptidase RseP; Provisional; Region: PRK10779 65393012743 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 65393012744 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 65393012745 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 65393012746 minor groove reading motif; other site 65393012747 helix-hairpin-helix signature motif; other site 65393012748 substrate binding pocket [chemical binding]; other site 65393012749 active site 65393012750 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 65393012751 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393012752 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393012753 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 65393012754 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393012755 phosphoribulokinase; Provisional; Region: PRK07429 65393012756 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 65393012757 active site 65393012758 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 65393012759 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 65393012760 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 65393012761 dimerization interface [polypeptide binding]; other site 65393012762 FAD binding pocket [chemical binding]; other site 65393012763 FAD binding motif [chemical binding]; other site 65393012764 catalytic residues [active] 65393012765 NAD binding pocket [chemical binding]; other site 65393012766 phosphate binding motif [ion binding]; other site 65393012767 beta-alpha-beta structure motif; other site 65393012768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 65393012769 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 65393012770 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 65393012771 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 65393012772 TIGR03032 family protein; Region: TIGR03032 65393012773 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 65393012774 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 65393012775 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 65393012776 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 65393012777 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 65393012778 metal ion-dependent adhesion site (MIDAS); other site 65393012779 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 65393012780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012781 active site 65393012782 phosphorylation site [posttranslational modification] 65393012783 intermolecular recognition site; other site 65393012784 dimerization interface [polypeptide binding]; other site 65393012785 Domain of unknown function DUF20; Region: UPF0118; cl00465 65393012786 Domain of unknown function DUF39; Region: DUF39; cl14897 65393012787 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 65393012788 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 65393012789 G1 box; other site 65393012790 GTP/Mg2+ binding site [chemical binding]; other site 65393012791 Switch I region; other site 65393012792 G2 box; other site 65393012793 Switch II region; other site 65393012794 G3 box; other site 65393012795 G4 box; other site 65393012796 G5 box; other site 65393012797 Domain of unknown function (DUF697); Region: DUF697; cl12064 65393012798 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 65393012799 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393012800 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 65393012801 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 65393012802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393012803 motif II; other site 65393012804 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 65393012805 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 65393012806 putative NAD(P) binding site [chemical binding]; other site 65393012807 putative substrate binding site [chemical binding]; other site 65393012808 catalytic Zn binding site [ion binding]; other site 65393012809 structural Zn binding site [ion binding]; other site 65393012810 dimer interface [polypeptide binding]; other site 65393012811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012812 active site 65393012813 phosphorylation site [posttranslational modification] 65393012814 intermolecular recognition site; other site 65393012815 dimerization interface [polypeptide binding]; other site 65393012816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 65393012817 metal binding site [ion binding]; metal-binding site 65393012818 active site 65393012819 I-site; other site 65393012820 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 65393012821 Peptidase family M48; Region: Peptidase_M48; cl12018 65393012822 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 65393012823 CbiD; Region: CbiD; cl00828 65393012824 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 65393012825 Ferritin-like domain; Region: Ferritin; pfam00210 65393012826 dimerization interface [polypeptide binding]; other site 65393012827 DPS ferroxidase diiron center [ion binding]; other site 65393012828 ion pore; other site 65393012829 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 65393012830 dimer interface [polypeptide binding]; other site 65393012831 [2Fe-2S] cluster binding site [ion binding]; other site 65393012832 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 65393012833 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 65393012834 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 65393012835 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393012836 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 65393012837 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393012838 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 65393012839 IMP binding site; other site 65393012840 dimer interface [polypeptide binding]; other site 65393012841 interdomain contacts; other site 65393012842 partial ornithine binding site; other site 65393012843 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 65393012844 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 65393012845 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 65393012846 GAF domain; Region: GAF; cl00853 65393012847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 65393012848 dimer interface [polypeptide binding]; other site 65393012849 phosphorylation site [posttranslational modification] 65393012850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393012851 ATP binding site [chemical binding]; other site 65393012852 Mg2+ binding site [ion binding]; other site 65393012853 G-X-G motif; other site 65393012854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012855 active site 65393012856 phosphorylation site [posttranslational modification] 65393012857 intermolecular recognition site; other site 65393012858 dimerization interface [polypeptide binding]; other site 65393012859 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 65393012860 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 65393012861 putative active site cavity [active] 65393012862 H+ Antiporter protein; Region: 2A0121; TIGR00900 65393012863 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352 65393012864 active site 65393012865 catalytic site [active] 65393012866 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 65393012867 Ligand Binding Site [chemical binding]; other site 65393012868 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 65393012869 active site 65393012870 trimer interface [polypeptide binding]; other site 65393012871 allosteric site; other site 65393012872 active site lid [active] 65393012873 hexamer (dimer of trimers) interface [polypeptide binding]; other site 65393012874 Arginase family; Region: Arginase; cl00306 65393012875 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; cl00418 65393012876 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 65393012877 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393012878 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393012879 putative active site [active] 65393012880 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 65393012881 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393012882 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 65393012883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 65393012884 Coenzyme A binding pocket [chemical binding]; other site 65393012885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 65393012886 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 65393012887 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 65393012888 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393012889 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 65393012890 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393012891 tellurium resistance terB-like protein; Region: terB_like; cd07177 65393012892 metal binding site [ion binding]; metal-binding site 65393012893 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 65393012894 GTPase CgtA; Reviewed; Region: obgE; PRK12299 65393012895 GTP1/OBG; Region: GTP1_OBG; pfam01018 65393012896 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 65393012897 G1 box; other site 65393012898 GTP/Mg2+ binding site [chemical binding]; other site 65393012899 Switch I region; other site 65393012900 G2 box; other site 65393012901 G3 box; other site 65393012902 Switch II region; other site 65393012903 G4 box; other site 65393012904 G5 box; other site 65393012905 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 65393012906 hypothetical protein; Provisional; Region: PRK00468; cl00794 65393012907 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 65393012908 BolA-like protein; Region: BolA; cl00386 65393012909 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393012910 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393012911 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393012912 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393012913 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 65393012914 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 65393012915 substrate binding site [chemical binding]; other site 65393012916 hexamer interface [polypeptide binding]; other site 65393012917 metal binding site [ion binding]; metal-binding site 65393012918 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 65393012919 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 65393012920 catalytic residues [active] 65393012921 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 65393012922 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 65393012923 Walker A/P-loop; other site 65393012924 ATP binding site [chemical binding]; other site 65393012925 Q-loop/lid; other site 65393012926 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393012927 ABC transporter signature motif; other site 65393012928 Walker B; other site 65393012929 D-loop; other site 65393012930 H-loop/switch region; other site 65393012931 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 65393012932 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 65393012933 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 65393012934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 65393012935 motif II; other site 65393012936 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 65393012937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393012938 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 65393012939 Probable transposase; Region: OrfB_IS605; pfam01385 65393012940 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393012941 Archaeal ATPase; Region: Arch_ATPase; pfam01637 65393012942 Helix-turn-helix domains; Region: HTH; cl00088 65393012943 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 65393012944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393012945 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 65393012946 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 65393012947 Substrate binding site; other site 65393012948 Mg++ binding site; other site 65393012949 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 65393012950 active site 65393012951 substrate binding site [chemical binding]; other site 65393012952 CoA binding site [chemical binding]; other site 65393012953 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 65393012954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393012955 active site 65393012956 phosphorylation site [posttranslational modification] 65393012957 intermolecular recognition site; other site 65393012958 dimerization interface [polypeptide binding]; other site 65393012959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 65393012960 Zn2+ binding site [ion binding]; other site 65393012961 Mg2+ binding site [ion binding]; other site 65393012962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 65393012963 Transposase IS200 like; Region: Y1_Tnp; cl00848 65393012964 Probable transposase; Region: OrfB_IS605; pfam01385 65393012965 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 65393012966 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 65393012967 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 65393012968 putative ADP-binding pocket [chemical binding]; other site 65393012969 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 65393012970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393012971 NAD(P) binding site [chemical binding]; other site 65393012972 active site 65393012973 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 65393012974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393012975 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 65393012976 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 65393012977 DXD motif; other site 65393012978 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 65393012979 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393012980 active site 65393012981 Bacterial sugar transferase; Region: Bac_transf; cl00939 65393012982 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 65393012983 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 65393012984 Probable Catalytic site; other site 65393012985 metal-binding site 65393012986 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 65393012987 trimer interface [polypeptide binding]; other site 65393012988 active site 65393012989 substrate binding site [chemical binding]; other site 65393012990 CoA binding site [chemical binding]; other site 65393012991 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 65393012992 FAD binding domain; Region: FAD_binding_4; pfam01565 65393012993 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 65393012994 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393012995 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 65393012996 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 65393012997 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 65393012998 Moco binding site; other site 65393012999 metal coordination site [ion binding]; other site 65393013000 ABC-2 type transporter; Region: ABC2_membrane; cl11417 65393013001 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 65393013002 active site 65393013003 dimer interface [polypeptide binding]; other site 65393013004 metal binding site [ion binding]; metal-binding site 65393013005 Cupin domain; Region: Cupin_2; cl09118 65393013006 TIR domain; Region: TIR; cl02060 65393013007 TIR domain; Region: TIR; cl02060 65393013008 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 65393013009 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393013010 structural tetrad; other site 65393013011 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393013012 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393013013 structural tetrad; other site 65393013014 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393013015 structural tetrad; other site 65393013016 XisH protein; Region: XisH; pfam08814 65393013017 XisI protein; Region: XisI; pfam08869 65393013018 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393013019 Protein of unknown function (DUF433); Region: DUF433; cl01030 65393013020 Protein of unknown function DUF82; Region: DUF82; pfam01927 65393013021 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 65393013022 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 65393013023 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 65393013024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393013025 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 65393013026 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 65393013027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393013028 S-adenosylmethionine binding site [chemical binding]; other site 65393013029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 65393013030 Family of unknown function (DUF490); Region: DUF490; pfam04357 65393013031 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 65393013032 active site 65393013033 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 65393013034 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 65393013035 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393013036 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 65393013037 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 65393013038 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013039 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 65393013040 Walker A/P-loop; other site 65393013041 ATP binding site [chemical binding]; other site 65393013042 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 65393013043 active site 65393013044 catalytic residues [active] 65393013045 Uncharacterized conserved protein [Function unknown]; Region: COG5592 65393013046 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 65393013047 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 65393013048 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 65393013049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393013050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393013051 S-adenosylmethionine binding site [chemical binding]; other site 65393013052 SOS regulatory protein LexA; Region: lexA; TIGR00498 65393013053 Helix-turn-helix domains; Region: HTH; cl00088 65393013054 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 65393013055 Catalytic site [active] 65393013056 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 65393013057 dimer interface [polypeptide binding]; other site 65393013058 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 65393013059 putative radical transfer pathway; other site 65393013060 diiron center [ion binding]; other site 65393013061 tyrosyl radical; other site 65393013062 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393013063 Domain of unknown function DUF29; Region: DUF29; pfam01724 65393013064 ATP cone domain; Region: ATP-cone; pfam03477 65393013065 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 65393013066 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 65393013067 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 65393013068 thioester formation/cholesterol transfer; other site 65393013069 protein-splicing catalytic site; other site 65393013070 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 65393013071 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 65393013072 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 65393013073 dimerization interface [polypeptide binding]; other site 65393013074 putative ATP binding site [chemical binding]; other site 65393013075 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 65393013076 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 65393013077 Pantoate-beta-alanine ligase; Region: PanC; cd00560 65393013078 active site 65393013079 ATP-binding site [chemical binding]; other site 65393013080 pantoate-binding site; other site 65393013081 HXXH motif; other site 65393013082 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 65393013083 CMP-binding site; other site 65393013084 The sites determining sugar specificity; other site 65393013085 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 65393013086 homotrimer interaction site [polypeptide binding]; other site 65393013087 active site 65393013088 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 65393013089 tandem repeat interface [polypeptide binding]; other site 65393013090 oligomer interface [polypeptide binding]; other site 65393013091 active site residues [active] 65393013092 EamA-like transporter family; Region: EamA; cl01037 65393013093 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 65393013094 EamA-like transporter family; Region: EamA; cl01037 65393013095 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393013096 putative acyl-acceptor binding pocket; other site 65393013097 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 65393013098 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 65393013099 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 65393013100 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 65393013101 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 65393013102 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 65393013103 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 65393013104 Cysteine-rich domain; Region: CCG; pfam02754 65393013105 Cysteine-rich domain; Region: CCG; pfam02754 65393013106 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 65393013107 FAD binding domain; Region: FAD_binding_4; pfam01565 65393013108 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 65393013109 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 65393013110 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 65393013111 active site 65393013112 catalytic residues [active] 65393013113 metal binding site [ion binding]; metal-binding site 65393013114 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 65393013115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393013116 Probable transposase; Region: OrfB_IS605; pfam01385 65393013117 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393013118 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 65393013119 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393013120 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 65393013121 DNA binding site [nucleotide binding] 65393013122 Int/Topo IB signature motif; other site 65393013123 active site 65393013124 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393013125 putative active site [active] 65393013126 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393013127 putative active site [active] 65393013128 TrwC relaxase; Region: TrwC; cl08490 65393013129 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 65393013130 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013131 DNA helicase, putative; Region: TIGR00376 65393013132 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 65393013133 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 65393013134 ParB-like nuclease domain; Region: ParBc; cl02129 65393013135 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 65393013136 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393013137 P-loop; other site 65393013138 Magnesium ion binding site [ion binding]; other site 65393013139 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393013140 Magnesium ion binding site [ion binding]; other site 65393013141 seryl-tRNA synthetase; Provisional; Region: PRK05431 65393013142 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 65393013143 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 65393013144 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 65393013145 Di-iron ligands [ion binding]; other site 65393013146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393013147 Helix-turn-helix domains; Region: HTH; cl00088 65393013148 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 65393013149 DNA binding site [nucleotide binding] 65393013150 active site 65393013151 Int/Topo IB signature motif; other site 65393013152 catalytic residues [active] 65393013153 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393013154 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393013155 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393013156 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393013157 Fasciclin domain; Region: Fasciclin; cl02663 65393013158 Helix-turn-helix domains; Region: HTH; cl00088 65393013159 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 65393013160 polymerase nucleotide-binding site; other site 65393013161 DNA-binding residues [nucleotide binding]; DNA binding site 65393013162 nucleotide binding site [chemical binding]; other site 65393013163 primase nucleotide-binding site [nucleotide binding]; other site 65393013164 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 65393013165 TIR domain; Region: TIR; cl02060 65393013166 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 65393013167 Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958 65393013168 NodB motif; other site 65393013169 putative active site [active] 65393013170 putative catalytic site [active] 65393013171 hypothetical protein; Provisional; Region: PRK14709 65393013172 D5 N terminal like; Region: D5_N; cl07360 65393013173 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 65393013174 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393013175 Phage integrase family; Region: Phage_integrase; pfam00589 65393013176 DNA binding site [nucleotide binding] 65393013177 Int/Topo IB signature motif; other site 65393013178 active site 65393013179 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 65393013180 putative active site [active] 65393013181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393013182 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 65393013183 Walker A motif; other site 65393013184 ATP binding site [chemical binding]; other site 65393013185 Walker B motif; other site 65393013186 arginine finger; other site 65393013187 TIR domain; Region: TIR; cl02060 65393013188 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 65393013189 DNA binding residues [nucleotide binding] 65393013190 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 65393013191 TIR domain; Region: TIR; cl02060 65393013192 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 65393013193 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 65393013194 active site 65393013195 nucleophile elbow; other site 65393013196 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 65393013197 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393013198 active site 65393013199 ATP binding site [chemical binding]; other site 65393013200 substrate binding site [chemical binding]; other site 65393013201 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 65393013202 activation loop (A-loop); other site 65393013203 activation loop (A-loop); other site 65393013204 Bacterial SH3 domain; Region: SH3_3; cl02551 65393013205 MobA/MobL family; Region: MobA_MobL; pfam03389 65393013206 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 65393013207 GIY-YIG motif/motif A; other site 65393013208 active site 65393013209 catalytic site [active] 65393013210 metal binding site [ion binding]; metal-binding site 65393013211 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 65393013212 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 65393013213 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 65393013214 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393013215 DNA binding site [nucleotide binding] 65393013216 Int/Topo IB signature motif; other site 65393013217 active site 65393013218 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 65393013219 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013220 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 65393013221 Walker A motif; other site 65393013222 ATP binding site [chemical binding]; other site 65393013223 Walker B motif; other site 65393013224 MobA/MobL family; Region: MobA_MobL; pfam03389 65393013225 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 65393013226 core dimer interface [polypeptide binding]; other site 65393013227 L11 interface [polypeptide binding]; other site 65393013228 putative EF-Tu interaction site [polypeptide binding]; other site 65393013229 putative EF-G interaction site [polypeptide binding]; other site 65393013230 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 65393013231 GIY-YIG motif/motif A; other site 65393013232 active site 65393013233 catalytic site [active] 65393013234 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 65393013235 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393013236 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 65393013237 DNA binding site [nucleotide binding] 65393013238 Int/Topo IB signature motif; other site 65393013239 active site 65393013240 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 65393013241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013242 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393013243 structural tetrad; other site 65393013244 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393013245 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393013246 structural tetrad; other site 65393013247 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 65393013248 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393013249 Phage integrase family; Region: Phage_integrase; pfam00589 65393013250 DNA binding site [nucleotide binding] 65393013251 Int/Topo IB signature motif; other site 65393013252 active site 65393013253 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 65393013254 non-specific DNA binding site [nucleotide binding]; other site 65393013255 salt bridge; other site 65393013256 sequence-specific DNA binding site [nucleotide binding]; other site 65393013257 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 65393013258 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 65393013259 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 65393013260 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 65393013261 DNA-directed RNA polymerase subunit B'; Validated; Region: PRK07225 65393013262 Integrase core domain; Region: rve; cl01316 65393013263 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 65393013264 IPP transferase; Region: IPPT; cl00403 65393013265 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 65393013266 Phd_YefM; Region: PhdYeFM; cl09153 65393013267 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393013268 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393013269 Phd_YefM; Region: PhdYeFM; cl09153 65393013270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 65393013271 non-specific DNA binding site [nucleotide binding]; other site 65393013272 salt bridge; other site 65393013273 sequence-specific DNA binding site [nucleotide binding]; other site 65393013274 Double zinc ribbon; Region: DZR; pfam12773 65393013275 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 65393013276 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393013277 DNA binding site [nucleotide binding] 65393013278 Int/Topo IB signature motif; other site 65393013279 active site 65393013280 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393013281 structural tetrad; other site 65393013282 FOG: WD40 repeat [General function prediction only]; Region: COG2319 65393013283 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 65393013284 structural tetrad; other site 65393013285 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 65393013286 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 65393013287 integrase; Region: int; PHA00730 65393013288 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 65393013289 LemA family; Region: LemA; cl00742 65393013290 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013291 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013292 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013293 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 65393013294 CHAT domain; Region: CHAT; cl02083 65393013295 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013296 Walker A/P-loop; other site 65393013297 ATP binding site [chemical binding]; other site 65393013298 Q-loop/lid; other site 65393013299 GUN4-like; Region: GUN4; pfam05419 65393013300 Peptidase family M48; Region: Peptidase_M48; cl12018 65393013301 AMOP domain; Region: AMOP; cl02758 65393013302 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 65393013303 dimer interface [polypeptide binding]; other site 65393013304 ssDNA binding site [nucleotide binding]; other site 65393013305 tetramer (dimer of dimers) interface [polypeptide binding]; other site 65393013306 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 65393013307 RNA/DNA hybrid binding site [nucleotide binding]; other site 65393013308 active site 65393013309 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 65393013310 Divergent AAA domain; Region: AAA_4; pfam04326 65393013311 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 65393013312 GUN4-like; Region: GUN4; pfam05419 65393013313 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 65393013314 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 65393013315 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 65393013316 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 65393013317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393013318 active site 65393013319 phosphorylation site [posttranslational modification] 65393013320 intermolecular recognition site; other site 65393013321 Ycf46; Provisional; Region: ycf46; CHL00195 65393013322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393013323 Walker A motif; other site 65393013324 ATP binding site [chemical binding]; other site 65393013325 Walker B motif; other site 65393013326 arginine finger; other site 65393013327 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 65393013328 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013329 Walker A motif; other site 65393013330 ATP binding site [chemical binding]; other site 65393013331 Walker B motif; other site 65393013332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 65393013333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393013334 DNA binding residues [nucleotide binding] 65393013335 dimerization interface [polypeptide binding]; other site 65393013336 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 65393013337 DdrB-like protein; Region: DdrB; pfam12747 65393013338 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 65393013339 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013340 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 65393013341 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 65393013342 Surface antigen; Region: Bac_surface_Ag; cl03097 65393013343 haemagglutination activity domain; Region: Haemagg_act; cl05436 65393013344 CHAT domain; Region: CHAT; cl02083 65393013345 CHASE2 domain; Region: CHASE2; cl01732 65393013346 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 65393013347 ParB-like nuclease domain; Region: ParBc; cl02129 65393013348 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 65393013349 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 65393013350 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393013351 P-loop; other site 65393013352 Magnesium ion binding site [ion binding]; other site 65393013353 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393013354 Magnesium ion binding site [ion binding]; other site 65393013355 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 65393013356 polymerase nucleotide-binding site; other site 65393013357 DNA-binding residues [nucleotide binding]; DNA binding site 65393013358 nucleotide binding site [chemical binding]; other site 65393013359 primase nucleotide-binding site [nucleotide binding]; other site 65393013360 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 65393013361 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 65393013362 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 65393013363 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 65393013364 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 65393013365 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 65393013366 ATP binding site [chemical binding]; other site 65393013367 putative Mg++ binding site [ion binding]; other site 65393013368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 65393013369 nucleotide binding region [chemical binding]; other site 65393013370 ATP-binding site [chemical binding]; other site 65393013371 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 65393013372 DNA polymerase III subunit beta; Validated; Region: PRK05643 65393013373 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 65393013374 putative DNA binding surface [nucleotide binding]; other site 65393013375 dimer interface [polypeptide binding]; other site 65393013376 beta-clamp/clamp loader binding surface; other site 65393013377 beta-clamp/translesion DNA polymerase binding surface; other site 65393013378 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 65393013379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013380 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 65393013381 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 65393013382 active site 65393013383 catalytic site [active] 65393013384 substrate binding site [chemical binding]; other site 65393013385 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic; Region: POLBc; cl10023 65393013386 active site 65393013387 metal-binding site 65393013388 DNA polymerase III subunit delta; Validated; Region: PRK07452 65393013389 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 65393013390 DNA polymerase III subunit delta'; Validated; Region: PRK07399 65393013391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 65393013393 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 65393013394 Probable transposase; Region: OrfB_IS605; pfam01385 65393013395 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 65393013396 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 65393013397 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 65393013398 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 65393013399 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 65393013400 putative active site [active] 65393013401 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 65393013402 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 65393013403 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892 65393013404 CRISPR/Cas system-associated protein Cas8c'; Region: Cas8c'_I-D; cl11893 65393013405 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 65393013406 DEAD-like helicases superfamily; Region: DEXDc; smart00487 65393013407 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013408 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013409 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09703 65393013410 TSC-22/dip/bun family; Region: TSC22; cl01853 65393013411 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013412 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013413 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013414 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393013415 P-loop; other site 65393013416 Magnesium ion binding site [ion binding]; other site 65393013417 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393013418 Magnesium ion binding site [ion binding]; other site 65393013419 KilA-N domain; Region: KilA-N; pfam04383 65393013420 Endonuclease I; Region: Endonuclease_1; cl01003 65393013421 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 65393013422 classical (c) SDRs; Region: SDR_c; cd05233 65393013423 NAD(P) binding site [chemical binding]; other site 65393013424 active site 65393013425 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393013426 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 65393013427 DNA binding site [nucleotide binding] 65393013428 Int/Topo IB signature motif; other site 65393013429 active site 65393013430 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 65393013431 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 65393013432 AAA-like domain; Region: AAA_10; pfam12846 65393013433 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 65393013434 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 65393013435 active site 65393013436 metal binding site [ion binding]; metal-binding site 65393013437 Phage associated DNA primase [General function prediction only]; Region: COG3378 65393013438 D5 N terminal like; Region: D5_N; cl07360 65393013439 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 65393013440 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013441 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013442 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013443 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393013444 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 65393013445 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013446 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 65393013447 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 65393013448 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 65393013449 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 65393013450 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 65393013451 DNA binding residues [nucleotide binding] 65393013452 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 65393013453 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 65393013454 Surface antigen; Region: Bac_surface_Ag; cl03097 65393013455 haemagglutination activity domain; Region: Haemagg_act; cl05436 65393013456 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 65393013457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 65393013458 binding surface 65393013459 TPR motif; other site 65393013460 CHAT domain; Region: CHAT; cl02083 65393013461 CHASE2 domain; Region: CHASE2; cl01732 65393013462 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013463 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013464 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013465 Transposase; Region: HTH_Tnp_IS630; pfam01710 65393013466 Integrase core domain; Region: rve; cl01316 65393013467 YCII-related domain; Region: YCII; cl00999 65393013468 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013469 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013470 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 65393013471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393013472 Walker A motif; other site 65393013473 ATP binding site [chemical binding]; other site 65393013474 Walker B motif; other site 65393013475 arginine finger; other site 65393013476 DNA polymerase III subunit delta; Validated; Region: PRK07452 65393013477 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 65393013478 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 65393013479 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 65393013480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 65393013481 active site 65393013482 phosphorylation site [posttranslational modification] 65393013483 intermolecular recognition site; other site 65393013484 dimerization interface [polypeptide binding]; other site 65393013485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393013486 DNA binding residues [nucleotide binding] 65393013487 dimerization interface [polypeptide binding]; other site 65393013488 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013489 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013490 DdrB-like protein; Region: DdrB; pfam12747 65393013491 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 65393013492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 65393013493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 65393013494 DNA binding residues [nucleotide binding] 65393013495 dimerization interface [polypeptide binding]; other site 65393013496 AAA-like domain; Region: AAA_10; pfam12846 65393013497 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 65393013498 endonuclease III; Region: ENDO3c; smart00478 65393013499 minor groove reading motif; other site 65393013500 helix-hairpin-helix signature motif; other site 65393013501 substrate binding pocket [chemical binding]; other site 65393013502 active site 65393013503 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 65393013504 ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702 65393013505 catalytic nucleophile [active] 65393013506 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 65393013507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 65393013509 active site 65393013510 phosphorylation site [posttranslational modification] 65393013511 intermolecular recognition site; other site 65393013512 Ycf46; Provisional; Region: ycf46; CHL00195 65393013513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 65393013514 Walker A motif; other site 65393013515 ATP binding site [chemical binding]; other site 65393013516 Walker B motif; other site 65393013517 arginine finger; other site 65393013518 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 65393013519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013520 Walker A motif; other site 65393013521 ATP binding site [chemical binding]; other site 65393013522 Walker B motif; other site 65393013523 Transposase [DNA replication, recombination, and repair]; Region: COG5421 65393013524 Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229 65393013525 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 65393013526 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 65393013527 Int/Topo IB signature motif; other site 65393013528 active site 65393013529 DNA binding site [nucleotide binding] 65393013530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393013531 short chain dehydrogenase; Provisional; Region: PRK06181 65393013532 NAD(P) binding site [chemical binding]; other site 65393013533 active site 65393013534 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 65393013535 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 65393013536 putative NAD(P) binding site [chemical binding]; other site 65393013537 putative substrate binding site [chemical binding]; other site 65393013538 catalytic Zn binding site [ion binding]; other site 65393013539 structural Zn binding site [ion binding]; other site 65393013540 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 65393013541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393013542 S-adenosylmethionine binding site [chemical binding]; other site 65393013543 Uncharacterized conserved protein [Function unknown]; Region: COG2128 65393013544 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 65393013545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393013546 Helix-turn-helix domains; Region: HTH; cl00088 65393013547 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 65393013548 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 65393013549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 65393013550 Helix-turn-helix domains; Region: HTH; cl00088 65393013551 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013552 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393013553 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 65393013554 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 65393013555 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 65393013556 CpeS-like protein; Region: CpeS; pfam09367 65393013557 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 65393013558 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 65393013559 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 65393013560 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 65393013561 Phycobilisome protein; Region: Phycobilisome; cl08227 65393013562 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393013563 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 65393013564 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 65393013565 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 65393013566 protein binding surface [polypeptide binding]; other site 65393013567 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 65393013568 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 65393013569 Phycobilisome protein; Region: Phycobilisome; cl08227 65393013570 Phycobilisome protein; Region: Phycobilisome; cl08227 65393013571 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 65393013572 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393013573 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393013574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393013575 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393013576 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 65393013577 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 65393013578 HicB family; Region: HicB; pfam05534 65393013579 CpeS-like protein; Region: CpeS; pfam09367 65393013580 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 65393013581 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 65393013582 YcaO-like family; Region: YcaO; cl09146 65393013583 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 65393013584 Protein kinase domain; Region: Pkinase; pfam00069 65393013585 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393013586 active site 65393013587 ATP binding site [chemical binding]; other site 65393013588 substrate binding site [chemical binding]; other site 65393013589 activation loop (A-loop); other site 65393013590 Predicted ATPase [General function prediction only]; Region: COG3899 65393013591 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 65393013592 GAF domain; Region: GAF; cl00853 65393013593 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013594 Walker A motif; other site 65393013595 ATP binding site [chemical binding]; other site 65393013596 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 65393013597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 65393013598 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 65393013599 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 65393013600 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 65393013601 Walker A/P-loop; other site 65393013602 ATP binding site [chemical binding]; other site 65393013603 Q-loop/lid; other site 65393013604 ABC transporter signature motif; other site 65393013605 Walker B; other site 65393013606 D-loop; other site 65393013607 H-loop/switch region; other site 65393013608 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 65393013609 ABC-ATPase subunit interface; other site 65393013610 dimer interface [polypeptide binding]; other site 65393013611 putative PBP binding regions; other site 65393013612 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 65393013613 ABC-ATPase subunit interface; other site 65393013614 dimer interface [polypeptide binding]; other site 65393013615 putative PBP binding regions; other site 65393013616 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 65393013617 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 65393013618 inhibitor-cofactor binding pocket; inhibition site 65393013619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393013620 catalytic residue [active] 65393013621 Condensation domain; Region: Condensation; pfam00668 65393013622 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013623 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 65393013624 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013625 thioester reductase domain; Region: Thioester-redct; TIGR01746 65393013626 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 65393013627 putative NAD(P) binding site [chemical binding]; other site 65393013628 active site 65393013629 putative substrate binding site [chemical binding]; other site 65393013630 peptide synthase; Provisional; Region: PRK12467 65393013631 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013632 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013633 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 65393013634 Condensation domain; Region: Condensation; pfam00668 65393013635 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013636 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 65393013637 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013638 peptide synthase; Provisional; Region: PRK12316 65393013639 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013640 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013641 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 65393013642 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 65393013643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393013644 S-adenosylmethionine binding site [chemical binding]; other site 65393013645 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 65393013646 peptide synthase; Provisional; Region: PRK12467 65393013647 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013648 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013649 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013650 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013651 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 65393013652 acyl-CoA synthetase; Validated; Region: PRK05850 65393013653 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013654 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013655 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013656 peptide synthase; Provisional; Region: PRK12467 65393013657 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393013659 S-adenosylmethionine binding site [chemical binding]; other site 65393013660 peptide synthase; Provisional; Region: PRK12467 65393013661 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013662 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 65393013663 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 65393013664 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 65393013665 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 65393013666 N-terminal plug; other site 65393013667 ligand-binding site [chemical binding]; other site 65393013668 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 65393013669 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 65393013670 siderophore binding site; other site 65393013671 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 65393013672 putative dimer interface [polypeptide binding]; other site 65393013673 putative [2Fe-2S] cluster binding site [ion binding]; other site 65393013674 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 65393013675 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393013676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013677 Walker A/P-loop; other site 65393013678 ATP binding site [chemical binding]; other site 65393013679 Q-loop/lid; other site 65393013680 ABC transporter signature motif; other site 65393013681 Walker B; other site 65393013682 D-loop; other site 65393013683 H-loop/switch region; other site 65393013684 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 65393013685 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393013686 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013687 Walker A/P-loop; other site 65393013688 ATP binding site [chemical binding]; other site 65393013689 Q-loop/lid; other site 65393013690 ABC transporter signature motif; other site 65393013691 Walker B; other site 65393013692 D-loop; other site 65393013693 H-loop/switch region; other site 65393013694 Penicillin amidase; Region: Penicil_amidase; pfam01804 65393013695 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 65393013696 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 65393013697 active site 65393013698 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 65393013699 Transposase; Region: HTH_Tnp_IS630; pfam01710 65393013700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393013701 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 65393013702 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 65393013703 Chain length determinant protein; Region: Wzz; cl01623 65393013704 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 65393013705 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 65393013706 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 65393013707 ABC-2 type transporter; Region: ABC2_membrane; cl11417 65393013708 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 65393013709 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 65393013710 Walker A/P-loop; other site 65393013711 ATP binding site [chemical binding]; other site 65393013712 Q-loop/lid; other site 65393013713 ABC transporter signature motif; other site 65393013714 Walker B; other site 65393013715 D-loop; other site 65393013716 H-loop/switch region; other site 65393013717 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 65393013718 putative carbohydrate binding site [chemical binding]; other site 65393013719 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 65393013720 putative trimer interface [polypeptide binding]; other site 65393013721 putative active site [active] 65393013722 putative substrate binding site [chemical binding]; other site 65393013723 putative CoA binding site [chemical binding]; other site 65393013724 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 65393013725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393013726 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 65393013727 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 65393013728 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 65393013729 inhibitor-cofactor binding pocket; inhibition site 65393013730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393013731 catalytic residue [active] 65393013732 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 65393013733 trimer interface [polypeptide binding]; other site 65393013734 active site 65393013735 substrate binding site [chemical binding]; other site 65393013736 CoA binding site [chemical binding]; other site 65393013737 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 65393013738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 65393013739 NAD(P) binding site [chemical binding]; other site 65393013740 active site 65393013741 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 65393013742 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 65393013743 inhibitor-cofactor binding pocket; inhibition site 65393013744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 65393013745 catalytic residue [active] 65393013746 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393013747 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 65393013748 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 65393013749 Ligand binding site; other site 65393013750 metal-binding site 65393013751 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393013752 active site 65393013753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393013754 active site 65393013755 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 65393013756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393013757 active site 65393013758 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 65393013759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 65393013760 active site 65393013761 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393013762 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393013763 Exostosin family; Region: Exostosin; pfam03016 65393013764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 65393013765 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 65393013766 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 65393013767 active site 65393013768 dimer interface [polypeptide binding]; other site 65393013769 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 65393013770 Ligand Binding Site [chemical binding]; other site 65393013771 Molecular Tunnel; other site 65393013772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393013773 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 65393013774 putative ADP-binding pocket [chemical binding]; other site 65393013775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393013776 S-adenosylmethionine binding site [chemical binding]; other site 65393013777 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 65393013778 putative metal binding site; other site 65393013779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 65393013780 S-adenosylmethionine binding site [chemical binding]; other site 65393013781 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 65393013782 Integrase core domain; Region: rve; cl01316 65393013783 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013784 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 65393013785 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013786 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013787 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 65393013789 binding surface 65393013790 TPR motif; other site 65393013791 CHAT domain; Region: CHAT; cl02083 65393013792 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 65393013793 CHASE2 domain; Region: CHASE2; cl01732 65393013794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 65393013795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 65393013796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 65393013797 ATP binding site [chemical binding]; other site 65393013798 Mg2+ binding site [ion binding]; other site 65393013799 G-X-G motif; other site 65393013800 Uncharacterized conserved protein [Function unknown]; Region: COG5464 65393013801 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 65393013802 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013803 high affinity sulphate transporter 1; Region: sulP; TIGR00815 65393013804 Permease family; Region: Xan_ur_permease; cl00967 65393013805 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 65393013806 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 65393013807 Catalytic domain of Protein Kinases; Region: PKc; cd00180 65393013808 active site 65393013809 ATP binding site [chemical binding]; other site 65393013810 substrate binding site [chemical binding]; other site 65393013811 activation loop (A-loop); other site 65393013812 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 65393013813 active site 65393013814 NTP binding site [chemical binding]; other site 65393013815 metal binding triad [ion binding]; metal-binding site 65393013816 antibiotic binding site [chemical binding]; other site 65393013817 Protein of unknown function DUF86; Region: DUF86; cl01031 65393013818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 65393013819 Integrase core domain; Region: rve; cl01316 65393013820 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 65393013821 ParB-like nuclease domain; Region: ParBc; cl02129 65393013822 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 65393013823 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 65393013824 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393013825 P-loop; other site 65393013826 Magnesium ion binding site [ion binding]; other site 65393013827 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 65393013828 Magnesium ion binding site [ion binding]; other site 65393013829 Helix-turn-helix domains; Region: HTH; cl00088 65393013830 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 65393013831 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 65393013832 Fe-S cluster binding site [ion binding]; other site 65393013833 active site 65393013834 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013835 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013836 Transposase [DNA replication, recombination, and repair]; Region: COG5433 65393013837 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 65393013838 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 65393013839 CRISPR-associated protein, TIGR03985 family; Region: TIGR03985 65393013840 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742 65393013841 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 65393013842 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 65393013843 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 65393013844 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 65393013845 putative active site [active] 65393013846 putative NTP binding site [chemical binding]; other site 65393013847 putative nucleic acid binding site [nucleotide binding]; other site 65393013848 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 65393013849 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 65393013850 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 65393013851 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 65393013852 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 65393013853 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 65393013854 Transposase; Region: HTH_Tnp_IS630; pfam01710 65393013855 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 65393013856 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 65393013857 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 65393013858 Walker A/P-loop; other site 65393013859 ATP binding site [chemical binding]; other site 65393013860 Q-loop/lid; other site 65393013861 ABC transporter signature motif; other site 65393013862 Walker B; other site 65393013863 D-loop; other site 65393013864 H-loop/switch region; other site 65393013865 Transposase; Region: HTH_Tnp_IS630; pfam01710 65393013866 Integrase core domain; Region: rve; cl01316 65393013867 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 65393013868 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 65393013869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 65393013870 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 65393013871 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 65393013872 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 65393013873 active site 65393013874 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 65393013875 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 65393013876 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 65393013877 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013878 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 65393013879 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013880 peptide synthase; Provisional; Region: PRK12316 65393013881 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013882 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013883 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 65393013884 Condensation domain; Region: Condensation; pfam00668 65393013885 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013886 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 65393013887 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013888 peptide synthase; Provisional; Region: PRK12467 65393013889 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 65393013890 Phosphopantetheine attachment site; Region: PP-binding; cl09936 65393013891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 65393013892 Transposase; Region: HTH_Tnp_IS630; pfam01710 65393013893 Integrase core domain; Region: rve; cl01316 65393013894 Transposase; Region: HTH_Tnp_IS630; pfam01710 65393013895 Integrase core domain; Region: rve; cl01316 65393013896 DNA primase, catalytic core; Region: dnaG; TIGR01391 65393013897 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 65393013898 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 65393013899 active site 65393013900 metal binding site [ion binding]; metal-binding site 65393013901 D5 N terminal like; Region: D5_N; cl07360 65393013902 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 65393013903 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 65393013904 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 65393013905 PemK-like protein; Region: PemK; cl00995