-- dump date 20120504_143042 -- class Genbank::misc_feature -- table misc_feature_note -- id note 41431000001 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 41431000002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431000003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431000004 DNA binding residues [nucleotide binding] 41431000005 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 41431000006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431000007 Helix-turn-helix domains; Region: HTH; cl00088 41431000008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 41431000009 Integrase core domain; Region: rve; cl01316 41431000010 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 41431000011 Phage integrase family; Region: Phage_integrase; pfam00589 41431000012 DNA binding site [nucleotide binding] 41431000013 Int/Topo IB signature motif; other site 41431000014 active site 41431000015 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431000016 active site 41431000017 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000018 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 41431000019 inhibitor binding site; inhibition site 41431000020 catalytic motif [active] 41431000021 Catalytic residue [active] 41431000022 Active site flap [active] 41431000023 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 41431000024 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000025 YcfA-like protein; Region: YcfA; cl00752 41431000026 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431000027 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431000028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431000029 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 41431000030 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 41431000031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 41431000032 Helix-turn-helix domains; Region: HTH; cl00088 41431000033 Transposase; Region: DDE_Tnp_ISL3; pfam01610 41431000034 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431000035 active site 41431000036 NTP binding site [chemical binding]; other site 41431000037 metal binding triad [ion binding]; metal-binding site 41431000038 antibiotic binding site [chemical binding]; other site 41431000039 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 41431000040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431000041 Helix-turn-helix domains; Region: HTH; cl00088 41431000042 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000043 DNA primase, catalytic core; Region: dnaG; TIGR01391 41431000044 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 41431000045 Phage associated DNA primase [General function prediction only]; Region: COG3378 41431000046 D5 N terminal like; Region: D5_N; cl07360 41431000047 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 41431000048 RFC reduced folate carrier; Region: rfc; TIGR00806 41431000049 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 41431000050 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000051 RHS Repeat; Region: RHS_repeat; cl11982 41431000052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000053 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 41431000054 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 41431000055 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431000056 dimerization interface [polypeptide binding]; other site 41431000057 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431000058 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 41431000059 protein binding surface [polypeptide binding]; other site 41431000060 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431000061 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 41431000062 protein binding surface [polypeptide binding]; other site 41431000063 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431000064 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000065 Phycobilisome protein; Region: Phycobilisome; cl08227 41431000066 Phycobilisome protein; Region: Phycobilisome; cl08227 41431000067 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 41431000068 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 41431000069 Phycobilisome protein; Region: Phycobilisome; cl08227 41431000070 secreted effector protein PipB; Provisional; Region: PRK15197 41431000071 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000072 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000073 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000074 CpeS-like protein; Region: CpeS; pfam09367 41431000075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431000076 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431000077 Probable transposase; Region: OrfB_IS605; pfam01385 41431000078 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431000079 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431000080 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 41431000081 CpeS-like protein; Region: CpeS; pfam09367 41431000082 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431000083 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 41431000084 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431000085 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 41431000086 PemK-like protein; Region: PemK; cl00995 41431000087 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000088 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431000089 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 41431000090 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 41431000091 Helix-turn-helix domains; Region: HTH; cl00088 41431000092 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431000093 T-DNA border endonuclease VirD1; Region: VirD1; cl06387 41431000094 PemK-like protein; Region: PemK; cl00995 41431000095 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 41431000096 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 41431000097 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 41431000098 DNA binding site [nucleotide binding] 41431000099 Int/Topo IB signature motif; other site 41431000100 active site 41431000101 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000102 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431000103 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431000104 P-loop; other site 41431000105 Magnesium ion binding site [ion binding]; other site 41431000106 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431000107 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000108 putative active site [active] 41431000109 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 41431000110 hypothetical protein; Validated; Region: PRK06672 41431000111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000112 Walker A motif; other site 41431000113 ATP binding site [chemical binding]; other site 41431000114 Walker B motif; other site 41431000115 arginine finger; other site 41431000116 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 41431000117 DnaA box-binding interface [nucleotide binding]; other site 41431000118 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431000119 phosphopeptide binding site; other site 41431000120 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431000121 metal binding site [ion binding]; metal-binding site 41431000122 active site 41431000123 I-site; other site 41431000124 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 41431000125 Domain of unknown function (DUF427); Region: DUF427; cl00998 41431000126 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 41431000127 Clp amino terminal domain; Region: Clp_N; pfam02861 41431000128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000129 Walker A motif; other site 41431000130 ATP binding site [chemical binding]; other site 41431000131 Walker B motif; other site 41431000132 arginine finger; other site 41431000133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000134 Walker A motif; other site 41431000135 ATP binding site [chemical binding]; other site 41431000136 Walker B motif; other site 41431000137 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 41431000138 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431000139 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 41431000140 Ligand binding site; other site 41431000141 Putative Catalytic site; other site 41431000142 DXD motif; other site 41431000143 UbiA prenyltransferase family; Region: UbiA; cl00337 41431000144 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 41431000145 nickel binding site [ion binding]; other site 41431000146 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431000147 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 41431000148 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 41431000149 Protein of unknown function (DUF1390); Region: DUF1390; pfam07150 41431000150 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 41431000151 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 41431000152 active site 41431000153 catalytic tetrad [active] 41431000154 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 41431000155 RuvA N terminal domain; Region: RuvA_N; pfam01330 41431000156 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 41431000157 Protein kinase C-related kinase homology region 1 domain; also known as the ACC (antiparallel coiled-coil) finger domain or Rho-binding domain. Found in vertebrate PRK1 and yeast PKC1 protein kinases C; those found in rhophilin bind RhoGTP; those in PRK1...; Region: HR1; cl00087 41431000158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 41431000159 PAS fold; Region: PAS_3; pfam08447 41431000160 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431000161 GAF domain; Region: GAF; cl00853 41431000162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431000163 metal binding site [ion binding]; metal-binding site 41431000164 active site 41431000165 I-site; other site 41431000166 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 41431000167 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 41431000168 substrate binding site [chemical binding]; other site 41431000169 ATP binding site [chemical binding]; other site 41431000170 Predicted methyltransferases [General function prediction only]; Region: COG0313 41431000171 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 41431000172 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000173 putative active site [active] 41431000174 Clp protease ATP binding subunit; Region: clpC; CHL00095 41431000175 Clp amino terminal domain; Region: Clp_N; pfam02861 41431000176 Clp amino terminal domain; Region: Clp_N; pfam02861 41431000177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000178 Walker A motif; other site 41431000179 ATP binding site [chemical binding]; other site 41431000180 Walker B motif; other site 41431000181 arginine finger; other site 41431000182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000183 Walker A motif; other site 41431000184 ATP binding site [chemical binding]; other site 41431000185 Walker B motif; other site 41431000186 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 41431000187 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431000188 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431000189 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 41431000190 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 41431000191 active site 41431000192 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431000193 MBOAT family; Region: MBOAT; cl00738 41431000194 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 41431000195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431000196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431000197 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 41431000198 catalytic residues [active] 41431000199 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 41431000200 Panthothenate kinase [Coenzyme metabolism]; Region: CoaA; COG1072 41431000201 enoyl-CoA hydratase; Provisional; Region: PRK06190 41431000202 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 41431000203 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 41431000204 metal binding site [ion binding]; metal-binding site 41431000205 dimer interface [polypeptide binding]; other site 41431000206 Flavin Reductases; Region: FlaRed; cl00801 41431000207 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 41431000208 transmembrane helices; other site 41431000209 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 41431000210 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 41431000211 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 41431000212 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 41431000213 Rhamnan synthesis protein F; Region: RgpF; cl01529 41431000214 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 41431000215 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 41431000216 NAD binding site [chemical binding]; other site 41431000217 homodimer interface [polypeptide binding]; other site 41431000218 active site 41431000219 substrate binding site [chemical binding]; other site 41431000220 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431000221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431000222 active site 41431000223 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431000224 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431000225 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431000226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431000227 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431000228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431000229 active site 41431000230 Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364 41431000231 Putative cyclase; Region: Cyclase; cl00814 41431000232 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 41431000233 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431000234 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431000235 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 41431000236 classical (c) SDRs; Region: SDR_c; cd05233 41431000237 NAD(P) binding site [chemical binding]; other site 41431000238 active site 41431000239 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 41431000240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431000241 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 41431000242 ligand binding site; other site 41431000243 tetramer interface; other site 41431000244 Photosystem II protein; Region: PSII; cl08223 41431000245 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 41431000246 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 41431000247 D1 interface; other site 41431000248 chlorophyll binding site; other site 41431000249 pheophytin binding site; other site 41431000250 beta carotene binding site; other site 41431000251 cytochrome b559 beta interface; other site 41431000252 quinone binding site; other site 41431000253 cytochrome b559 alpha interface; other site 41431000254 protein J interface; other site 41431000255 protein H interface; other site 41431000256 protein X interface; other site 41431000257 core light harvesting protein interface; other site 41431000258 protein L interface; other site 41431000259 CP43 interface; other site 41431000260 protein T interface; other site 41431000261 Fe binding site [ion binding]; other site 41431000262 protein M interface; other site 41431000263 Mn-stabilizing polypeptide interface; other site 41431000264 bromide binding site; other site 41431000265 cytochrome c-550 interface; other site 41431000266 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000267 putative active site [active] 41431000268 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 41431000269 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431000270 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 41431000271 Walker A/P-loop; other site 41431000272 ATP binding site [chemical binding]; other site 41431000273 Q-loop/lid; other site 41431000274 ABC transporter signature motif; other site 41431000275 Walker B; other site 41431000276 D-loop; other site 41431000277 H-loop/switch region; other site 41431000278 Protein of unknown function (DUF990); Region: DUF990; cl01496 41431000279 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 41431000280 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 41431000281 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 41431000282 Ycf39; Provisional; Region: ycf39; CHL00194 41431000283 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 41431000284 NAD(P) binding site [chemical binding]; other site 41431000285 putative active site [active] 41431000286 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 41431000287 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 41431000288 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 41431000289 substrate-cofactor binding pocket; other site 41431000290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431000291 catalytic residue [active] 41431000292 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 41431000293 proline aminopeptidase P II; Provisional; Region: PRK10879 41431000294 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 41431000295 active site 41431000296 Protein of unknown function DUF124; Region: DUF124; cl00884 41431000297 Protein of unknown function DUF124; Region: DUF124; cl00884 41431000298 Protein of unknown function DUF124; Region: DUF124; cl00884 41431000299 Peptidase family M48; Region: Peptidase_M48; cl12018 41431000300 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 41431000301 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 41431000302 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 41431000303 Zn2+ binding site [ion binding]; other site 41431000304 Mg2+ binding site [ion binding]; other site 41431000305 Bacterial SH3 domain; Region: SH3_3; cl02551 41431000306 Bacterial SH3 domain; Region: SH3_3; cl02551 41431000307 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000308 putative active site [active] 41431000309 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 41431000310 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 41431000311 Mg++ binding site [ion binding]; other site 41431000312 putative catalytic motif [active] 41431000313 substrate binding site [chemical binding]; other site 41431000314 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 41431000315 Protein of unknown function, DUF393; Region: DUF393; cl01136 41431000316 Cupin domain; Region: Cupin_2; cl09118 41431000317 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 41431000318 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 41431000319 inhibitor-cofactor binding pocket; inhibition site 41431000320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431000321 catalytic residue [active] 41431000322 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 41431000323 DNA binding residues [nucleotide binding] 41431000324 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431000325 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 41431000326 cofactor binding site; other site 41431000327 DNA binding site [nucleotide binding] 41431000328 substrate interaction site [chemical binding]; other site 41431000329 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 41431000330 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 41431000331 putative substrate binding site [chemical binding]; other site 41431000332 putative ATP binding site [chemical binding]; other site 41431000333 EVE domain; Region: EVE; cl00728 41431000334 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 41431000335 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 41431000336 putative active site [active] 41431000337 metal binding site [ion binding]; metal-binding site 41431000338 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000339 putative active site [active] 41431000340 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431000341 Ligand Binding Site [chemical binding]; other site 41431000342 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 41431000343 putative active site pocket [active] 41431000344 4-fold oligomerization interface [polypeptide binding]; other site 41431000345 metal binding residues [ion binding]; metal-binding site 41431000346 3-fold/trimer interface [polypeptide binding]; other site 41431000347 Double zinc ribbon; Region: DZR; pfam12773 41431000348 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 41431000349 Protein phosphatase 2C; Region: PP2C; pfam00481 41431000350 active site 41431000351 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 41431000352 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 41431000353 NADP binding site [chemical binding]; other site 41431000354 active site 41431000355 putative substrate binding site [chemical binding]; other site 41431000356 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 41431000357 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 41431000358 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 41431000359 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431000360 catalytic loop [active] 41431000361 iron binding site [ion binding]; other site 41431000362 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 41431000363 4Fe-4S binding domain; Region: Fer4; cl02805 41431000364 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 41431000365 dimer interface [polypeptide binding]; other site 41431000366 [2Fe-2S] cluster binding site [ion binding]; other site 41431000367 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 41431000368 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 41431000369 SLBB domain; Region: SLBB; pfam10531 41431000370 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 41431000371 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 41431000372 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 41431000373 putative dimer interface [polypeptide binding]; other site 41431000374 [2Fe-2S] cluster binding site [ion binding]; other site 41431000375 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000376 putative active site [active] 41431000377 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 41431000378 heme binding pocket [chemical binding]; other site 41431000379 heme ligand [chemical binding]; other site 41431000380 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 41431000381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431000382 FeS/SAM binding site; other site 41431000383 HemN C-terminal region; Region: HemN_C; pfam06969 41431000384 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 41431000385 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 41431000386 FMN binding site [chemical binding]; other site 41431000387 active site 41431000388 substrate binding site [chemical binding]; other site 41431000389 catalytic residue [active] 41431000390 Cupin domain; Region: Cupin_2; cl09118 41431000391 Helix-turn-helix domains; Region: HTH; cl00088 41431000392 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 41431000393 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 41431000394 dimer interface [polypeptide binding]; other site 41431000395 FMN binding site [chemical binding]; other site 41431000396 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431000397 HSP70 interaction site [polypeptide binding]; other site 41431000398 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000399 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000400 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000401 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 41431000402 Proline dehydrogenase; Region: Pro_dh; cl03282 41431000403 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 41431000404 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 41431000405 Glutamate binding site [chemical binding]; other site 41431000406 homodimer interface [polypeptide binding]; other site 41431000407 NAD binding site [chemical binding]; other site 41431000408 catalytic residues [active] 41431000409 GTP-binding protein Der; Reviewed; Region: PRK00093 41431000410 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 41431000411 G1 box; other site 41431000412 GTP/Mg2+ binding site [chemical binding]; other site 41431000413 Switch I region; other site 41431000414 G2 box; other site 41431000415 Switch II region; other site 41431000416 G3 box; other site 41431000417 G4 box; other site 41431000418 G5 box; other site 41431000419 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 41431000420 G1 box; other site 41431000421 GTP/Mg2+ binding site [chemical binding]; other site 41431000422 Switch I region; other site 41431000423 G2 box; other site 41431000424 G3 box; other site 41431000425 Switch II region; other site 41431000426 G4 box; other site 41431000427 G5 box; other site 41431000428 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000429 putative active site [active] 41431000430 Peptidase family M48; Region: Peptidase_M48; cl12018 41431000431 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 41431000432 active site 41431000433 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431000434 active site 41431000435 ATP binding site [chemical binding]; other site 41431000436 substrate binding site [chemical binding]; other site 41431000437 activation loop (A-loop); other site 41431000438 diaminopimelate decarboxylase; Region: lysA; TIGR01048 41431000439 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 41431000440 active site 41431000441 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 41431000442 substrate binding site [chemical binding]; other site 41431000443 catalytic residues [active] 41431000444 dimer interface [polypeptide binding]; other site 41431000445 TIGR00159 family protein; Region: TIGR00159 41431000446 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 41431000447 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 41431000448 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 41431000449 catalytic residue [active] 41431000450 putative FPP diphosphate binding site; other site 41431000451 putative FPP binding hydrophobic cleft; other site 41431000452 dimer interface [polypeptide binding]; other site 41431000453 putative IPP diphosphate binding site; other site 41431000454 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 41431000455 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 41431000456 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 41431000457 DNA binding site [nucleotide binding] 41431000458 catalytic residue [active] 41431000459 H2TH interface [polypeptide binding]; other site 41431000460 putative catalytic residues [active] 41431000461 turnover-facilitating residue; other site 41431000462 intercalation triad [nucleotide binding]; other site 41431000463 8OG recognition residue [nucleotide binding]; other site 41431000464 putative reading head residues; other site 41431000465 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 41431000466 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 41431000467 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 41431000468 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 41431000469 proline aminopeptidase P II; Provisional; Region: PRK10879 41431000470 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 41431000471 active site 41431000472 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 41431000473 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431000474 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 41431000475 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 41431000476 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 41431000477 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 41431000478 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 41431000479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431000480 NAD(P) binding site [chemical binding]; other site 41431000481 active site 41431000482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431000483 TPR motif; other site 41431000484 binding surface 41431000485 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 41431000486 lipoprotein signal peptidase; Provisional; Region: PRK14787 41431000487 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 41431000488 hypothetical protein; Provisional; Region: PRK05926 41431000489 biotin synthase; Region: bioB; TIGR00433 41431000490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431000491 FeS/SAM binding site; other site 41431000492 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 41431000493 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 41431000494 phosphodiesterase; Provisional; Region: PRK12704 41431000495 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431000496 XisI protein; Region: XisI; pfam08869 41431000497 XisH protein; Region: XisH; pfam08814 41431000498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431000499 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431000500 Probable transposase; Region: OrfB_IS605; pfam01385 41431000501 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431000502 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 41431000503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431000504 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431000505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431000506 DNA binding residues [nucleotide binding] 41431000507 Divergent PAP2 family; Region: DUF212; cl00855 41431000508 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 41431000509 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 41431000510 substrate binding pocket [chemical binding]; other site 41431000511 chain length determination region; other site 41431000512 substrate-Mg2+ binding site; other site 41431000513 catalytic residues [active] 41431000514 aspartate-rich region 1; other site 41431000515 active site lid residues [active] 41431000516 aspartate-rich region 2; other site 41431000517 Frequency clock protein; Region: FRQ; pfam09421 41431000518 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 41431000519 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 41431000520 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 41431000521 active site 41431000522 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 41431000523 GUN4-like; Region: GUN4; pfam05419 41431000524 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431000525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431000526 Coenzyme A binding pocket [chemical binding]; other site 41431000527 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 41431000528 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 41431000529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431000530 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431000531 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431000532 DNA binding residues [nucleotide binding] 41431000533 primosome assembly protein PriA; Validated; Region: PRK05580 41431000534 primosome assembly protein PriA; Validated; Region: PRK05580 41431000535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431000536 ATP binding site [chemical binding]; other site 41431000537 putative Mg++ binding site [ion binding]; other site 41431000538 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431000539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431000540 Coenzyme A binding pocket [chemical binding]; other site 41431000541 putative acetyltransferase; Provisional; Region: PRK03624 41431000542 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431000543 YcfA-like protein; Region: YcfA; cl00752 41431000544 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431000545 GAF domain; Region: GAF; cl00853 41431000546 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431000547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431000548 geranylgeranyl reductase; Region: ChlP; TIGR02028 41431000549 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431000550 CpeS-like protein; Region: CpeS; pfam09367 41431000551 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 41431000552 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 41431000553 GTP binding site; other site 41431000554 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 41431000555 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 41431000556 Ligand Binding Site [chemical binding]; other site 41431000557 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 41431000558 apolar tunnel; other site 41431000559 heme binding site [chemical binding]; other site 41431000560 dimerization interface [polypeptide binding]; other site 41431000561 Peptidase family M48; Region: Peptidase_M48; cl12018 41431000562 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 41431000563 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 41431000564 putative active site [active] 41431000565 putative FMN binding site [chemical binding]; other site 41431000566 putative substrate binding site [chemical binding]; other site 41431000567 6-phosphofructokinase; Provisional; Region: PRK03202 41431000568 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 41431000569 active site 41431000570 ADP/pyrophosphate binding site [chemical binding]; other site 41431000571 dimerization interface [polypeptide binding]; other site 41431000572 allosteric effector site; other site 41431000573 fructose-1,6-bisphosphate binding site; other site 41431000574 ABC-2 type transporter; Region: ABC2_membrane; cl11417 41431000575 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 41431000576 catalytic site [active] 41431000577 G-X2-G-X-G-K; other site 41431000578 Domain of unknown function (DUF370); Region: DUF370; cl00898 41431000579 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431000580 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431000581 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 41431000582 [2Fe-2S] cluster binding site [ion binding]; other site 41431000583 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 41431000584 putative alpha subunit interface [polypeptide binding]; other site 41431000585 putative active site [active] 41431000586 putative substrate binding site [chemical binding]; other site 41431000587 Fe binding site [ion binding]; other site 41431000588 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 41431000589 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 41431000590 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 41431000591 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 41431000592 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 41431000593 Catalytic site [active] 41431000594 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 41431000595 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 41431000596 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 41431000597 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 41431000598 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 41431000599 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 41431000600 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 41431000601 NAD binding site [chemical binding]; other site 41431000602 dimerization interface [polypeptide binding]; other site 41431000603 product binding site; other site 41431000604 substrate binding site [chemical binding]; other site 41431000605 zinc binding site [ion binding]; other site 41431000606 catalytic residues [active] 41431000607 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 41431000608 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 41431000609 active site 41431000610 catalytic tetrad [active] 41431000611 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 41431000612 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 41431000613 peptide chain release factor 1; Validated; Region: prfA; PRK00591 41431000614 RF-1 domain; Region: RF-1; cl02875 41431000615 RF-1 domain; Region: RF-1; cl02875 41431000616 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 41431000617 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431000618 dimer interface [polypeptide binding]; other site 41431000619 putative metal binding site [ion binding]; other site 41431000620 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431000621 YcfA-like protein; Region: YcfA; cl00752 41431000622 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 41431000623 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431000624 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 41431000625 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 41431000626 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431000627 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 41431000628 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 41431000629 substrate binding site [chemical binding]; other site 41431000630 ligand binding site [chemical binding]; other site 41431000631 Protein of unknown function, DUF486; Region: DUF486; cl01236 41431000632 Transglycosylase; Region: Transgly; cl07896 41431000633 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 41431000634 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 41431000635 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 41431000636 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 41431000637 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 41431000638 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 41431000639 23S rRNA interface [nucleotide binding]; other site 41431000640 L3 interface [polypeptide binding]; other site 41431000641 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 41431000642 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 41431000643 dimerization interface 3.5A [polypeptide binding]; other site 41431000644 active site 41431000645 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 41431000646 RNA polymerase alpha subunit; Region: rpoA; CHL00013 41431000647 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 41431000648 alphaNTD homodimer interface [polypeptide binding]; other site 41431000649 alphaNTD - beta interaction site [polypeptide binding]; other site 41431000650 alphaNTD - beta' interaction site [polypeptide binding]; other site 41431000651 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 41431000652 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 41431000653 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 41431000654 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 41431000655 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 41431000656 rRNA binding site [nucleotide binding]; other site 41431000657 predicted 30S ribosome binding site; other site 41431000658 adenylate kinase; Provisional; Region: adk; PRK02496 41431000659 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 41431000660 AMP-binding site [chemical binding]; other site 41431000661 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 41431000662 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 41431000663 SecY translocase; Region: SecY; pfam00344 41431000664 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 41431000665 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 41431000666 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 41431000667 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 41431000668 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 41431000669 23S rRNA interface [nucleotide binding]; other site 41431000670 L21e interface [polypeptide binding]; other site 41431000671 5S rRNA interface [nucleotide binding]; other site 41431000672 L27 interface [polypeptide binding]; other site 41431000673 L5 interface [polypeptide binding]; other site 41431000674 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 41431000675 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 41431000676 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 41431000677 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 41431000678 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 41431000679 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 41431000680 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 41431000681 KOW motif; Region: KOW; cl00354 41431000682 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 41431000683 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 41431000684 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 41431000685 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 41431000686 putative translocon interaction site; other site 41431000687 23S rRNA interface [nucleotide binding]; other site 41431000688 signal recognition particle (SRP54) interaction site; other site 41431000689 L23 interface [polypeptide binding]; other site 41431000690 trigger factor interaction site; other site 41431000691 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 41431000692 23S rRNA interface [nucleotide binding]; other site 41431000693 5S rRNA interface [nucleotide binding]; other site 41431000694 putative antibiotic binding site [chemical binding]; other site 41431000695 L25 interface [polypeptide binding]; other site 41431000696 L27 interface [polypeptide binding]; other site 41431000697 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 41431000698 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 41431000699 G-X-X-G motif; other site 41431000700 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 41431000701 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 41431000702 putative translocon binding site; other site 41431000703 protein-rRNA interface [nucleotide binding]; other site 41431000704 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 41431000705 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 41431000706 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 41431000707 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 41431000708 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 41431000709 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 41431000710 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 41431000711 UbiA prenyltransferase family; Region: UbiA; cl00337 41431000712 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 41431000713 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 41431000714 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 41431000715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 41431000716 substrate binding site [chemical binding]; other site 41431000717 oxyanion hole (OAH) forming residues; other site 41431000718 trimer interface [polypeptide binding]; other site 41431000719 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 41431000720 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 41431000721 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 41431000722 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 41431000723 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 41431000724 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 41431000725 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 41431000726 putative nucleic acid binding region [nucleotide binding]; other site 41431000727 G-X-X-G motif; other site 41431000728 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 41431000729 RNA binding site [nucleotide binding]; other site 41431000730 domain interface; other site 41431000731 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 41431000732 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 41431000733 putative catalytic site [active] 41431000734 putative metal binding site [ion binding]; other site 41431000735 putative phosphate binding site [ion binding]; other site 41431000736 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 41431000737 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 41431000738 Active Sites [active] 41431000739 Predicted permease; Region: DUF318; cl00487 41431000740 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 41431000741 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 41431000742 metal ion-dependent adhesion site (MIDAS); other site 41431000743 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 41431000744 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 41431000745 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 41431000746 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431000747 catalytic core [active] 41431000748 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000749 putative active site [active] 41431000750 NAD synthetase; Provisional; Region: PRK13981 41431000751 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 41431000752 multimer interface [polypeptide binding]; other site 41431000753 active site 41431000754 catalytic triad [active] 41431000755 protein interface 1 [polypeptide binding]; other site 41431000756 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 41431000757 homodimer interface [polypeptide binding]; other site 41431000758 NAD binding pocket [chemical binding]; other site 41431000759 ATP binding pocket [chemical binding]; other site 41431000760 Mg binding site [ion binding]; other site 41431000761 active-site loop [active] 41431000762 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 41431000763 nudix motif; other site 41431000764 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 41431000765 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 41431000766 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 41431000767 active site 41431000768 (T/H)XGH motif; other site 41431000769 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 41431000770 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 41431000771 active site 41431000772 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 41431000773 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 41431000774 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 41431000775 G1 box; other site 41431000776 GTP/Mg2+ binding site [chemical binding]; other site 41431000777 Switch I region; other site 41431000778 G2 box; other site 41431000779 G3 box; other site 41431000780 Switch II region; other site 41431000781 G4 box; other site 41431000782 G5 box; other site 41431000783 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 41431000784 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431000785 dimerization interface [polypeptide binding]; other site 41431000786 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 41431000787 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 41431000788 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 41431000789 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431000790 FtsH Extracellular; Region: FtsH_ext; pfam06480 41431000791 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 41431000792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000793 Walker A motif; other site 41431000794 ATP binding site [chemical binding]; other site 41431000795 Walker B motif; other site 41431000796 arginine finger; other site 41431000797 Peptidase family M41; Region: Peptidase_M41; pfam01434 41431000798 transcriptional regulator; Provisional; Region: PRK10632 41431000799 Helix-turn-helix domains; Region: HTH; cl00088 41431000800 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 41431000801 putative effector binding pocket; other site 41431000802 dimerization interface [polypeptide binding]; other site 41431000803 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 41431000804 Surface antigen; Region: Bac_surface_Ag; cl03097 41431000805 haemagglutination activity domain; Region: Haemagg_act; cl05436 41431000806 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 41431000807 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 41431000808 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 41431000809 active site 41431000810 catalytic tetrad [active] 41431000811 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000812 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000813 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000814 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000815 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 41431000816 SNF2 Helicase protein; Region: DUF3670; pfam12419 41431000817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431000818 ATP binding site [chemical binding]; other site 41431000819 putative Mg++ binding site [ion binding]; other site 41431000820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431000821 nucleotide binding region [chemical binding]; other site 41431000822 ATP-binding site [chemical binding]; other site 41431000823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 41431000824 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431000825 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 41431000826 ligand binding site; other site 41431000827 tetramer interface; other site 41431000828 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 41431000829 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 41431000830 Walker A/P-loop; other site 41431000831 ATP binding site [chemical binding]; other site 41431000832 Q-loop/lid; other site 41431000833 ABC transporter signature motif; other site 41431000834 Walker B; other site 41431000835 D-loop; other site 41431000836 H-loop/switch region; other site 41431000837 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 41431000838 putative carbohydrate binding site [chemical binding]; other site 41431000839 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 41431000840 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 41431000841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431000842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431000843 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 41431000844 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 41431000845 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 41431000846 Active_site [active] 41431000847 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 41431000848 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431000849 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431000850 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431000851 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431000852 Helix-turn-helix domains; Region: HTH; cl00088 41431000853 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 41431000854 4Fe-4S binding domain; Region: Fer4_5; pfam12801 41431000855 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431000856 ligand binding site [chemical binding]; other site 41431000857 flexible hinge region; other site 41431000858 Predicted ATPase [General function prediction only]; Region: COG4637 41431000859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431000860 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431000861 Uncharacterized conserved protein [Function unknown]; Region: COG3349 41431000862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431000863 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 41431000864 active site lid residues [active] 41431000865 substrate binding pocket [chemical binding]; other site 41431000866 catalytic residues [active] 41431000867 substrate-Mg2+ binding site; other site 41431000868 aspartate-rich region 1; other site 41431000869 aspartate-rich region 2; other site 41431000870 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 41431000871 MAEBL; Provisional; Region: PTZ00121 41431000872 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 41431000873 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 41431000874 Domain of unknown function (DUF814); Region: DUF814; pfam05670 41431000875 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 41431000876 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 41431000877 active site 41431000878 catalytic triad [active] 41431000879 oxyanion hole [active] 41431000880 ferrochelatase; Reviewed; Region: hemH; PRK00035 41431000881 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 41431000882 C-terminal domain interface [polypeptide binding]; other site 41431000883 active site 41431000884 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 41431000885 active site 41431000886 N-terminal domain interface [polypeptide binding]; other site 41431000887 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 41431000888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431000889 S-adenosylmethionine binding site [chemical binding]; other site 41431000890 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 41431000891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431000892 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 41431000893 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 41431000894 TM-ABC transporter signature motif; other site 41431000895 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 41431000896 nickel binding site [ion binding]; other site 41431000897 tocopherol O-methyltransferase; Region: PLN02244 41431000898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431000899 S-adenosylmethionine binding site [chemical binding]; other site 41431000900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431000901 binding surface 41431000902 TPR motif; other site 41431000903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431000904 binding surface 41431000905 TPR motif; other site 41431000906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431000907 binding surface 41431000908 TPR motif; other site 41431000909 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 41431000910 Protein of unknown function (DUF790); Region: DUF790; pfam05626 41431000911 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 41431000912 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 41431000913 catalytic residues [active] 41431000914 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 41431000915 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431000916 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431000917 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 41431000918 Late competence development protein ComFB; Region: ComFB; pfam10719 41431000919 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 41431000920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431000921 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431000922 DNA binding residues [nucleotide binding] 41431000923 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 41431000924 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 41431000925 putative active site pocket [active] 41431000926 dimerization interface [polypeptide binding]; other site 41431000927 putative catalytic residue [active] 41431000928 PEP-CTERM motif; Region: VPEP; cl15443 41431000929 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 41431000930 tartrate dehydrogenase; Provisional; Region: PRK08194 41431000931 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 41431000932 RNA/DNA binding site [nucleotide binding]; other site 41431000933 RRM dimerization site [polypeptide binding]; other site 41431000934 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 41431000935 aromatic arch; other site 41431000936 DCoH dimer interaction site [polypeptide binding]; other site 41431000937 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 41431000938 DCoH tetramer interaction site [polypeptide binding]; other site 41431000939 substrate binding site [chemical binding]; other site 41431000940 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431000941 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 41431000942 non-specific DNA interactions [nucleotide binding]; other site 41431000943 DNA binding site [nucleotide binding] 41431000944 sequence specific DNA binding site [nucleotide binding]; other site 41431000945 putative cAMP binding site [chemical binding]; other site 41431000946 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 41431000947 nucleotide binding site [chemical binding]; other site 41431000948 substrate binding site [chemical binding]; other site 41431000949 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 41431000950 nucleotide binding site [chemical binding]; other site 41431000951 substrate binding site [chemical binding]; other site 41431000952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431000953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431000954 S-adenosylmethionine binding site [chemical binding]; other site 41431000955 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 41431000956 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 41431000957 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 41431000958 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 41431000959 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 41431000960 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 41431000961 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431000962 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431000963 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 41431000964 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 41431000965 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 41431000966 Surface antigen; Region: Bac_surface_Ag; cl03097 41431000967 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 41431000968 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 41431000969 ATP binding site [chemical binding]; other site 41431000970 active site 41431000971 substrate binding site [chemical binding]; other site 41431000972 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 41431000973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 41431000974 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 41431000975 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 41431000976 Restriction endonuclease; Region: Mrr_cat; cl00747 41431000977 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431000978 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431000979 P-loop; other site 41431000980 Magnesium ion binding site [ion binding]; other site 41431000981 Ion channel; Region: Ion_trans_2; cl11596 41431000982 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431000983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431000984 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 41431000985 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 41431000986 FAD binding domain; Region: FAD_binding_4; pfam01565 41431000987 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 41431000988 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 41431000989 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 41431000990 active site 41431000991 Zn binding site [ion binding]; other site 41431000992 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 41431000993 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 41431000994 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 41431000995 active site 41431000996 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 41431000997 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431000998 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431000999 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 41431001000 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 41431001001 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 41431001002 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 41431001003 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 41431001004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 41431001005 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431001006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431001007 Probable transposase; Region: OrfB_IS605; pfam01385 41431001008 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431001009 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 41431001010 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 41431001011 substrate binding pocket [chemical binding]; other site 41431001012 chain length determination region; other site 41431001013 substrate-Mg2+ binding site; other site 41431001014 catalytic residues [active] 41431001015 aspartate-rich region 1; other site 41431001016 active site lid residues [active] 41431001017 aspartate-rich region 2; other site 41431001018 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 41431001019 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 41431001020 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 41431001021 active site 41431001022 ATP binding site [chemical binding]; other site 41431001023 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 41431001024 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 41431001025 MOSC domain; Region: MOSC; pfam03473 41431001026 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 41431001027 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 41431001028 chorismate binding enzyme; Region: Chorismate_bind; cl10555 41431001029 PsaD; Region: PsaD; cl03639 41431001030 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 41431001031 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431001032 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 41431001033 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 41431001034 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 41431001035 catalytic site [active] 41431001036 subunit interface [polypeptide binding]; other site 41431001037 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 41431001038 DNA-binding interface [nucleotide binding]; DNA binding site 41431001039 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001040 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431001041 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001042 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001043 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001044 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001045 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001046 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001047 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 41431001048 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 41431001049 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 41431001050 protein binding site [polypeptide binding]; other site 41431001051 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 41431001052 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 41431001053 Ligand binding site; other site 41431001054 Putative Catalytic site; other site 41431001055 DXD motif; other site 41431001056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431001057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431001058 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; cl15425 41431001059 hypothetical protein; Reviewed; Region: PRK00024 41431001060 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 41431001061 MPN+ (JAMM) motif; other site 41431001062 Zinc-binding site [ion binding]; other site 41431001063 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431001064 putative active site [active] 41431001065 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 41431001066 homotrimer interaction site [polypeptide binding]; other site 41431001067 active site 41431001068 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 41431001069 tandem repeat interface [polypeptide binding]; other site 41431001070 oligomer interface [polypeptide binding]; other site 41431001071 active site residues [active] 41431001072 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 41431001073 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 41431001074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 41431001075 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 41431001076 Protein of unknown function (DUF419); Region: DUF419; cl15265 41431001077 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 41431001078 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 41431001079 glutathione reductase; Validated; Region: PRK06116 41431001080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001081 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 41431001082 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 41431001083 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431001084 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431001085 putative binding surface; other site 41431001086 active site 41431001087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431001088 ATP binding site [chemical binding]; other site 41431001089 Mg2+ binding site [ion binding]; other site 41431001090 G-X-G motif; other site 41431001091 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 41431001092 Response regulator receiver domain; Region: Response_reg; pfam00072 41431001093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431001094 active site 41431001095 phosphorylation site [posttranslational modification] 41431001096 intermolecular recognition site; other site 41431001097 dimerization interface [polypeptide binding]; other site 41431001098 PEP-CTERM motif; Region: VPEP; cl15443 41431001099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431001100 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 41431001101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001102 binding surface 41431001103 TPR motif; other site 41431001104 Peptidase family M48; Region: Peptidase_M48; cl12018 41431001105 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 41431001106 Helix-turn-helix domains; Region: HTH; cl00088 41431001107 Helix-turn-helix domains; Region: HTH; cl00088 41431001108 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 41431001109 putative ABC transporter; Region: ycf24; CHL00085 41431001110 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 41431001111 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 41431001112 Walker A/P-loop; other site 41431001113 ATP binding site [chemical binding]; other site 41431001114 Q-loop/lid; other site 41431001115 ABC transporter signature motif; other site 41431001116 Walker B; other site 41431001117 D-loop; other site 41431001118 H-loop/switch region; other site 41431001119 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 41431001120 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 41431001121 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 41431001122 Aminotransferase class-V; Region: Aminotran_5; pfam00266 41431001123 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431001124 catalytic residue [active] 41431001125 30S ribosomal protein S1; Reviewed; Region: PRK07400 41431001126 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 41431001127 RNA binding site [nucleotide binding]; other site 41431001128 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 41431001129 RNA binding site [nucleotide binding]; other site 41431001130 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 41431001131 RNA binding site [nucleotide binding]; other site 41431001132 Dienelactone hydrolase family; Region: DLH; pfam01738 41431001133 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431001134 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431001135 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 41431001136 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 41431001137 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 41431001138 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 41431001139 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 41431001140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001141 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; cl00418 41431001142 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 41431001143 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001144 Response regulator receiver domain; Region: Response_reg; pfam00072 41431001145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431001146 active site 41431001147 phosphorylation site [posttranslational modification] 41431001148 intermolecular recognition site; other site 41431001149 dimerization interface [polypeptide binding]; other site 41431001150 PAS domain S-box; Region: sensory_box; TIGR00229 41431001151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001152 putative active site [active] 41431001153 heme pocket [chemical binding]; other site 41431001154 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431001155 metal binding site [ion binding]; metal-binding site 41431001156 active site 41431001157 I-site; other site 41431001158 PAS domain S-box; Region: sensory_box; TIGR00229 41431001159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001160 putative active site [active] 41431001161 heme pocket [chemical binding]; other site 41431001162 PAS domain S-box; Region: sensory_box; TIGR00229 41431001163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001164 putative active site [active] 41431001165 heme pocket [chemical binding]; other site 41431001166 PAS fold; Region: PAS_4; pfam08448 41431001167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001168 PAS fold; Region: PAS_3; pfam08447 41431001169 putative active site [active] 41431001170 heme pocket [chemical binding]; other site 41431001171 PAS domain S-box; Region: sensory_box; TIGR00229 41431001172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001173 putative active site [active] 41431001174 heme pocket [chemical binding]; other site 41431001175 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001176 PAS fold; Region: PAS_3; pfam08447 41431001177 putative active site [active] 41431001178 heme pocket [chemical binding]; other site 41431001179 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 41431001180 Histidine kinase; Region: HisKA_2; cl06527 41431001181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431001182 ATP binding site [chemical binding]; other site 41431001183 Mg2+ binding site [ion binding]; other site 41431001184 G-X-G motif; other site 41431001185 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 41431001186 AMP binding site [chemical binding]; other site 41431001187 fructose-1,6-bisphosphatase family protein; Region: PLN02628 41431001188 metal binding site [ion binding]; metal-binding site 41431001189 active site 41431001190 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 41431001191 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001192 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 41431001193 catalytic triad [active] 41431001194 S-layer homology domain; Region: SLH; pfam00395 41431001195 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 41431001196 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 41431001197 cysteine synthase; Region: PLN02565 41431001198 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 41431001199 dimer interface [polypeptide binding]; other site 41431001200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431001201 catalytic residue [active] 41431001202 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431001203 HSP70 interaction site [polypeptide binding]; other site 41431001204 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 41431001205 putative homotetramer interface [polypeptide binding]; other site 41431001206 putative homodimer interface [polypeptide binding]; other site 41431001207 putative metal binding site [ion binding]; other site 41431001208 putative homodimer-homodimer interface [polypeptide binding]; other site 41431001209 putative allosteric switch controlling residues; other site 41431001210 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431001211 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431001212 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 41431001213 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 41431001214 active site 41431001215 dimer interface [polypeptide binding]; other site 41431001216 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 41431001217 dimer interface [polypeptide binding]; other site 41431001218 active site 41431001219 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 41431001220 putative active site [active] 41431001221 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 41431001222 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 41431001223 homooctamer interface [polypeptide binding]; other site 41431001224 active site 41431001225 Rhomboid family; Region: Rhomboid; cl11446 41431001226 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431001227 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431001228 active site 41431001229 ATP binding site [chemical binding]; other site 41431001230 substrate binding site [chemical binding]; other site 41431001231 activation loop (A-loop); other site 41431001232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 41431001233 Malic enzyme, N-terminal domain; Region: malic; pfam00390 41431001234 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 41431001235 putative NAD(P) binding site [chemical binding]; other site 41431001236 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 41431001237 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 41431001238 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 41431001239 active site 41431001240 catalytic residues [active] 41431001241 metal binding site [ion binding]; metal-binding site 41431001242 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 41431001243 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431001244 catalytic loop [active] 41431001245 iron binding site [ion binding]; other site 41431001246 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431001247 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431001248 glycogen branching enzyme; Provisional; Region: PRK05402 41431001249 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 41431001250 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 41431001251 active site 41431001252 catalytic site [active] 41431001253 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 41431001254 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 41431001255 active site 41431001256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001257 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 41431001258 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 41431001259 dinuclear metal binding motif [ion binding]; other site 41431001260 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 41431001261 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 41431001262 active site 41431001263 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 41431001264 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 41431001265 active site 41431001266 HIGH motif; other site 41431001267 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 41431001268 KMSKS motif; other site 41431001269 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 41431001270 tRNA binding surface [nucleotide binding]; other site 41431001271 anticodon binding site; other site 41431001272 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431001273 CHAT domain; Region: CHAT; cl02083 41431001274 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 41431001275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001276 binding surface 41431001277 TPR motif; other site 41431001278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001279 binding surface 41431001280 TPR motif; other site 41431001281 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 41431001282 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 41431001283 active site 41431001284 homodimer interface [polypeptide binding]; other site 41431001285 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001286 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 41431001287 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 41431001288 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 41431001289 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431001290 putative active site [active] 41431001291 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 41431001292 Helix-turn-helix domains; Region: HTH; cl00088 41431001293 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 41431001294 putative dimerization interface [polypeptide binding]; other site 41431001295 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 41431001296 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 41431001297 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 41431001298 TPP-binding site; other site 41431001299 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 41431001300 PYR/PP interface [polypeptide binding]; other site 41431001301 dimer interface [polypeptide binding]; other site 41431001302 TPP binding site [chemical binding]; other site 41431001303 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 41431001304 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 41431001305 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 41431001306 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 41431001307 catalytic triad [active] 41431001308 dimer interface [polypeptide binding]; other site 41431001309 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 41431001310 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431001311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431001312 active site 41431001313 phosphorylation site [posttranslational modification] 41431001314 intermolecular recognition site; other site 41431001315 dimerization interface [polypeptide binding]; other site 41431001316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431001317 DNA binding site [nucleotide binding] 41431001318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431001319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431001320 dimerization interface [polypeptide binding]; other site 41431001321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431001322 dimer interface [polypeptide binding]; other site 41431001323 phosphorylation site [posttranslational modification] 41431001324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431001325 ATP binding site [chemical binding]; other site 41431001326 Mg2+ binding site [ion binding]; other site 41431001327 G-X-G motif; other site 41431001328 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 41431001329 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 41431001330 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 41431001331 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 41431001332 NADP binding site [chemical binding]; other site 41431001333 active site 41431001334 putative substrate binding site [chemical binding]; other site 41431001335 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 41431001336 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 41431001337 substrate binding site; other site 41431001338 metal-binding site 41431001339 Oligomer interface; other site 41431001340 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 41431001341 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 41431001342 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 41431001343 NAD binding site [chemical binding]; other site 41431001344 substrate binding site [chemical binding]; other site 41431001345 homodimer interface [polypeptide binding]; other site 41431001346 active site 41431001347 Predicted domain in sensory proteins (DUF2308); Region: DUF2308; cl01731 41431001348 GAF domain; Region: GAF; cl00853 41431001349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431001350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431001351 dimer interface [polypeptide binding]; other site 41431001352 phosphorylation site [posttranslational modification] 41431001353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431001354 ATP binding site [chemical binding]; other site 41431001355 Mg2+ binding site [ion binding]; other site 41431001356 G-X-G motif; other site 41431001357 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 41431001358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 41431001359 Haemolysin XhlA; Region: XhlA; pfam10779 41431001360 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 41431001361 nucleoside/Zn binding site; other site 41431001362 dimer interface [polypeptide binding]; other site 41431001363 catalytic motif [active] 41431001364 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 41431001365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001366 NAD(P) binding site [chemical binding]; other site 41431001367 active site 41431001368 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 41431001369 dimer interface [polypeptide binding]; other site 41431001370 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 41431001371 molecular chaperone DnaK; Provisional; Region: PRK13411 41431001372 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 41431001373 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 41431001374 homotrimer interaction site [polypeptide binding]; other site 41431001375 putative active site [active] 41431001376 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 41431001377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431001378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431001379 homodimer interface [polypeptide binding]; other site 41431001380 catalytic residue [active] 41431001381 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 41431001382 HflK protein; Region: hflK; TIGR01933 41431001383 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 41431001384 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 41431001385 Protein export membrane protein; Region: SecD_SecF; cl14618 41431001386 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 41431001387 substrate binding pocket [chemical binding]; other site 41431001388 substrate-Mg2+ binding site; other site 41431001389 aspartate-rich region 1; other site 41431001390 aspartate-rich region 2; other site 41431001391 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 41431001392 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 41431001393 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 41431001394 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 41431001395 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cl11870 41431001396 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869 41431001397 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 41431001398 CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174 41431001399 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001400 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 41431001401 Predicted transcriptional regulator [Transcription]; Region: COG2378 41431001402 mce related protein; Region: MCE; cl15431 41431001403 mce related protein; Region: MCE; cl15431 41431001404 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 41431001405 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 41431001406 Walker A/P-loop; other site 41431001407 ATP binding site [chemical binding]; other site 41431001408 Q-loop/lid; other site 41431001409 ABC transporter signature motif; other site 41431001410 Walker B; other site 41431001411 D-loop; other site 41431001412 H-loop/switch region; other site 41431001413 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 41431001414 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 41431001415 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 41431001416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001417 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 41431001418 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 41431001419 iron-sulfur cluster [ion binding]; other site 41431001420 [2Fe-2S] cluster binding site [ion binding]; other site 41431001421 Uncharacterized conserved protein [Function unknown]; Region: COG3349 41431001422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001423 CHAT domain; Region: CHAT; cl02083 41431001424 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 41431001425 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 41431001426 Walker A/P-loop; other site 41431001427 ATP binding site [chemical binding]; other site 41431001428 Q-loop/lid; other site 41431001429 ABC transporter signature motif; other site 41431001430 Walker B; other site 41431001431 D-loop; other site 41431001432 H-loop/switch region; other site 41431001433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001434 FAD dependent oxidoreductase; Region: DAO; pfam01266 41431001435 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 41431001436 malate dehydrogenase; Reviewed; Region: PRK06223 41431001437 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 41431001438 NAD(P) binding site [chemical binding]; other site 41431001439 dimer interface [polypeptide binding]; other site 41431001440 tetramer (dimer of dimers) interface [polypeptide binding]; other site 41431001441 substrate binding site [chemical binding]; other site 41431001442 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 41431001443 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 41431001444 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 41431001445 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 41431001446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431001447 metal binding site [ion binding]; metal-binding site 41431001448 active site 41431001449 I-site; other site 41431001450 arginine-tRNA ligase; Region: PLN02286 41431001451 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 41431001452 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 41431001453 active site 41431001454 HIGH motif; other site 41431001455 KMSK motif region; other site 41431001456 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 41431001457 tRNA binding surface [nucleotide binding]; other site 41431001458 anticodon binding site; other site 41431001459 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 41431001460 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431001461 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 41431001462 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 41431001463 carboxyltransferase (CT) interaction site; other site 41431001464 biotinylation site [posttranslational modification]; other site 41431001465 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431001466 ligand binding site [chemical binding]; other site 41431001467 flexible hinge region; other site 41431001468 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 41431001469 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cd02259 41431001470 putative active site [active] 41431001471 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 41431001472 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001473 Walker A/P-loop; other site 41431001474 ATP binding site [chemical binding]; other site 41431001475 Q-loop/lid; other site 41431001476 ABC transporter signature motif; other site 41431001477 Walker B; other site 41431001478 D-loop; other site 41431001479 H-loop/switch region; other site 41431001480 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 41431001481 PPIC-type PPIASE domain; Region: Rotamase; cl08278 41431001482 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 41431001483 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431001484 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 41431001485 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 41431001486 ResB-like family; Region: ResB; pfam05140 41431001487 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431001488 catalytic loop [active] 41431001489 iron binding site [ion binding]; other site 41431001490 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 41431001491 active site 41431001492 dimerization interface [polypeptide binding]; other site 41431001493 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431001494 HSP70 interaction site [polypeptide binding]; other site 41431001495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001496 binding surface 41431001497 TPR motif; other site 41431001498 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 41431001499 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 41431001500 molybdopterin cofactor binding site; other site 41431001501 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 41431001502 molybdopterin cofactor binding site; other site 41431001503 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 41431001504 active site 41431001505 Ycf4; Region: Ycf4; cl03567 41431001506 FemAB family; Region: FemAB; cl11444 41431001507 Protein of unknown function, DUF482; Region: DUF482; pfam04339 41431001508 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 41431001509 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001510 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001511 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001512 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001513 CTP synthetase; Validated; Region: pyrG; PRK05380 41431001514 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 41431001515 Catalytic site [active] 41431001516 active site 41431001517 UTP binding site [chemical binding]; other site 41431001518 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 41431001519 active site 41431001520 putative oxyanion hole; other site 41431001521 catalytic triad [active] 41431001522 elongation factor P; Validated; Region: PRK00529 41431001523 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 41431001524 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 41431001525 RNA binding site [nucleotide binding]; other site 41431001526 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 41431001527 RNA binding site [nucleotide binding]; other site 41431001528 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 41431001529 carboxyltransferase (CT) interaction site; other site 41431001530 biotinylation site [posttranslational modification]; other site 41431001531 Peptidase family M48; Region: Peptidase_M48; cl12018 41431001532 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 41431001533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001534 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 41431001535 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 41431001536 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 41431001537 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 41431001538 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 41431001539 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001540 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431001541 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 41431001542 GIY-YIG motif/motif A; other site 41431001543 ATP-sulfurylase; Region: ATPS; cd00517 41431001544 active site 41431001545 HXXH motif; other site 41431001546 flexible loop; other site 41431001547 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 41431001548 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 41431001549 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 41431001550 catalytic residues [active] 41431001551 DNA gyrase subunit A; Validated; Region: PRK05560 41431001552 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 41431001553 CAP-like domain; other site 41431001554 active site 41431001555 primary dimer interface [polypeptide binding]; other site 41431001556 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001557 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001558 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001559 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001560 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001561 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001562 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 41431001563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431001564 ATP binding site [chemical binding]; other site 41431001565 putative Mg++ binding site [ion binding]; other site 41431001566 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431001567 nucleotide binding region [chemical binding]; other site 41431001568 ATP-binding site [chemical binding]; other site 41431001569 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 41431001570 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 41431001571 Archaeal ATPase; Region: Arch_ATPase; pfam01637 41431001572 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 41431001573 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431001574 structural tetrad; other site 41431001575 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431001576 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431001577 structural tetrad; other site 41431001578 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 41431001579 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 41431001580 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431001581 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 41431001582 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 41431001583 D-pathway; other site 41431001584 Putative ubiquinol binding site [chemical binding]; other site 41431001585 Low-spin heme (heme b) binding site [chemical binding]; other site 41431001586 Putative water exit pathway; other site 41431001587 Binuclear center (heme o3/CuB) [ion binding]; other site 41431001588 K-pathway; other site 41431001589 Putative proton exit pathway; other site 41431001590 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 41431001591 Subunit I/III interface [polypeptide binding]; other site 41431001592 signal recognition particle protein; Provisional; Region: PRK10867 41431001593 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 41431001594 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 41431001595 P loop; other site 41431001596 GTP binding site [chemical binding]; other site 41431001597 Signal peptide binding domain; Region: SRP_SPB; pfam02978 41431001598 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 41431001599 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431001600 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001601 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001602 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 41431001603 active site 41431001604 catalytic residues [active] 41431001605 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431001606 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431001607 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 41431001608 active site 41431001609 chaperone protein DnaJ; Provisional; Region: PRK14276 41431001610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431001611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001612 binding surface 41431001613 TPR motif; other site 41431001614 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 41431001615 dimer interface [polypeptide binding]; other site 41431001616 catalytic triad [active] 41431001617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431001618 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431001619 Probable transposase; Region: OrfB_IS605; pfam01385 41431001620 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431001621 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431001622 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 41431001623 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 41431001624 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 41431001625 active site 41431001626 metal binding site [ion binding]; metal-binding site 41431001627 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 41431001628 ArsC family; Region: ArsC; pfam03960 41431001629 catalytic residues [active] 41431001630 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 41431001631 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 41431001632 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431001633 putative active site [active] 41431001634 arogenate dehydrogenase; Reviewed; Region: PRK07417 41431001635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001636 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 41431001637 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 41431001638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001639 NAD(P) binding site [chemical binding]; other site 41431001640 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 41431001641 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 41431001642 DXD motif; other site 41431001643 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 41431001644 TM2 domain; Region: TM2; cl00984 41431001645 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 41431001646 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 41431001647 putative hydrophobic ligand binding site [chemical binding]; other site 41431001648 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 41431001649 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431001650 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 41431001651 C-terminal peptidase (prc); Region: prc; TIGR00225 41431001652 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 41431001653 protein binding site [polypeptide binding]; other site 41431001654 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 41431001655 Catalytic dyad [active] 41431001656 Domain of unknown function (DUF205); Region: DUF205; cl00410 41431001657 phosphoenolpyruvate synthase; Validated; Region: PRK06241 41431001658 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 41431001659 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 41431001660 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 41431001661 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 41431001662 Recombinase; Region: Recombinase; pfam07508 41431001663 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 41431001664 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 41431001665 active site 41431001666 (T/H)XGH motif; other site 41431001667 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 41431001668 cell division protein; Validated; Region: ftsH; CHL00176 41431001669 FtsH Extracellular; Region: FtsH_ext; pfam06480 41431001670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431001671 Walker A motif; other site 41431001672 ATP binding site [chemical binding]; other site 41431001673 Walker B motif; other site 41431001674 arginine finger; other site 41431001675 Peptidase family M41; Region: Peptidase_M41; pfam01434 41431001676 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 41431001677 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 41431001678 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 41431001679 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 41431001680 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 41431001681 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 41431001682 putative active site [active] 41431001683 Predicted ATPase [General function prediction only]; Region: COG4637 41431001684 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001685 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 41431001686 Q-loop/lid; other site 41431001687 ABC transporter signature motif; other site 41431001688 Walker B; other site 41431001689 D-loop; other site 41431001690 H-loop/switch region; other site 41431001691 Protein of unknown function (DUF423); Region: DUF423; cl01008 41431001692 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 41431001693 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 41431001694 NAD binding site [chemical binding]; other site 41431001695 substrate binding site [chemical binding]; other site 41431001696 active site 41431001697 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 41431001698 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 41431001699 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001700 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 41431001701 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 41431001702 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 41431001703 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431001704 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 41431001705 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431001706 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 41431001707 IMP binding site; other site 41431001708 dimer interface [polypeptide binding]; other site 41431001709 interdomain contacts; other site 41431001710 partial ornithine binding site; other site 41431001711 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 41431001712 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001713 Walker A/P-loop; other site 41431001714 ATP binding site [chemical binding]; other site 41431001715 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001716 ABC transporter signature motif; other site 41431001717 Walker B; other site 41431001718 D-loop; other site 41431001719 H-loop/switch region; other site 41431001720 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 41431001721 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 41431001722 substrate binding pocket [chemical binding]; other site 41431001723 membrane-bound complex binding site; other site 41431001724 hinge residues; other site 41431001725 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431001726 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 41431001727 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 41431001728 Cupin domain; Region: Cupin_2; cl09118 41431001729 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 41431001730 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 41431001731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431001732 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 41431001733 Fatty acid desaturase; Region: FA_desaturase; pfam00487 41431001734 Di-iron ligands [ion binding]; other site 41431001735 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 41431001736 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431001737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 41431001738 Integrase core domain; Region: rve; cl01316 41431001739 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 41431001740 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 41431001741 dimerization interface [polypeptide binding]; other site 41431001742 active site 41431001743 metal binding site [ion binding]; metal-binding site 41431001744 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 41431001745 dimerization interface [polypeptide binding]; other site 41431001746 active site 41431001747 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 41431001748 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 41431001749 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 41431001750 active site 41431001751 catalytic site [active] 41431001752 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 41431001753 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 41431001754 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 41431001755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431001756 Coenzyme A binding pocket [chemical binding]; other site 41431001757 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 41431001758 putative metal binding site [ion binding]; other site 41431001759 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 41431001760 tellurium resistance terB-like protein; Region: terB_like; cd07177 41431001761 metal binding site [ion binding]; metal-binding site 41431001762 16S rRNA methyltransferase B; Provisional; Region: PRK14901 41431001763 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 41431001764 putative RNA binding site [nucleotide binding]; other site 41431001765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431001766 S-adenosylmethionine binding site [chemical binding]; other site 41431001767 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 41431001768 metal ion-dependent adhesion site (MIDAS); other site 41431001769 Cupin domain; Region: Cupin_2; cl09118 41431001770 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 41431001771 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 41431001772 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 41431001773 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 41431001774 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 41431001775 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 41431001776 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 41431001777 B12 binding site [chemical binding]; other site 41431001778 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 41431001779 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 41431001780 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 41431001781 anti sigma factor interaction site; other site 41431001782 regulatory phosphorylation site [posttranslational modification]; other site 41431001783 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 41431001784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431001785 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 41431001786 Flavin Reductases; Region: FlaRed; cl00801 41431001787 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 41431001788 putative active site [active] 41431001789 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 41431001790 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431001791 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431001792 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431001793 DNA binding residues [nucleotide binding] 41431001794 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 41431001795 light-harvesting-like protein 3; Provisional; Region: PLN00014 41431001796 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431001797 structural tetrad; other site 41431001798 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 41431001799 Protein of unknown function, DUF393; Region: DUF393; cl01136 41431001800 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 41431001801 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 41431001802 active site 41431001803 HIGH motif; other site 41431001804 nucleotide binding site [chemical binding]; other site 41431001805 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 41431001806 active site 41431001807 KMSKS motif; other site 41431001808 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 41431001809 tRNA binding surface [nucleotide binding]; other site 41431001810 anticodon binding site; other site 41431001811 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 41431001812 phosphodiesterase; Provisional; Region: PRK12704 41431001813 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 41431001814 aromatic arch; other site 41431001815 DCoH dimer interaction site [polypeptide binding]; other site 41431001816 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 41431001817 DCoH tetramer interaction site [polypeptide binding]; other site 41431001818 substrate binding site [chemical binding]; other site 41431001819 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 41431001820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001821 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 41431001822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431001823 motif II; other site 41431001824 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 41431001825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431001826 FeS/SAM binding site; other site 41431001827 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 41431001828 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 41431001829 Ligand Binding Site [chemical binding]; other site 41431001830 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 41431001831 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 41431001832 substrate binding site [chemical binding]; other site 41431001833 glutamase interaction surface [polypeptide binding]; other site 41431001834 Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cl00012 41431001835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431001836 Coenzyme A binding pocket [chemical binding]; other site 41431001837 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 41431001838 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 41431001839 homodimer interface [polypeptide binding]; other site 41431001840 active site 41431001841 TDP-binding site; other site 41431001842 acceptor substrate-binding pocket; other site 41431001843 Helix-turn-helix domains; Region: HTH; cl00088 41431001844 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 41431001845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431001846 S-adenosylmethionine binding site [chemical binding]; other site 41431001847 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431001848 putative active site [active] 41431001849 GMP synthase; Reviewed; Region: guaA; PRK00074 41431001850 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 41431001851 AMP/PPi binding site [chemical binding]; other site 41431001852 candidate oxyanion hole; other site 41431001853 catalytic triad [active] 41431001854 potential glutamine specificity residues [chemical binding]; other site 41431001855 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 41431001856 ATP Binding subdomain [chemical binding]; other site 41431001857 Ligand Binding sites [chemical binding]; other site 41431001858 Dimerization subdomain; other site 41431001859 L-aspartate oxidase; Provisional; Region: PRK07395 41431001860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001861 domain; Region: Succ_DH_flav_C; pfam02910 41431001862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431001863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001864 TPR motif; other site 41431001865 binding surface 41431001866 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 41431001867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001868 TPR motif; other site 41431001869 binding surface 41431001870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001871 binding surface 41431001872 TPR motif; other site 41431001873 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 41431001874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001875 binding surface 41431001876 TPR motif; other site 41431001877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001878 binding surface 41431001879 TPR motif; other site 41431001880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001881 binding surface 41431001882 TPR motif; other site 41431001883 Chromate transporter; Region: Chromate_transp; pfam02417 41431001884 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 41431001885 Chromate transporter; Region: Chromate_transp; pfam02417 41431001886 DNA photolyase; Region: DNA_photolyase; pfam00875 41431001887 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 41431001888 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 41431001889 GUN4-like; Region: GUN4; pfam05419 41431001890 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 41431001891 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001892 Walker A/P-loop; other site 41431001893 ATP binding site [chemical binding]; other site 41431001894 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001895 Walker B; other site 41431001896 D-loop; other site 41431001897 H-loop/switch region; other site 41431001898 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431001899 putative active site [active] 41431001900 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 41431001901 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 41431001902 GDP-binding site [chemical binding]; other site 41431001903 ACT binding site; other site 41431001904 IMP binding site; other site 41431001905 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 41431001906 5S rRNA interface [nucleotide binding]; other site 41431001907 CTC domain interface [polypeptide binding]; other site 41431001908 L16 interface [polypeptide binding]; other site 41431001909 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 41431001910 metal-binding site 41431001911 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431001912 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431001913 active site 41431001914 Chloroplast import component protein (Tic20); Region: Tic20; cl09892 41431001915 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 41431001916 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 41431001917 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 41431001918 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 41431001919 trimer interface [polypeptide binding]; other site 41431001920 active site 41431001921 dimer interface [polypeptide binding]; other site 41431001922 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 41431001923 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 41431001924 Walker A/P-loop; other site 41431001925 ATP binding site [chemical binding]; other site 41431001926 Q-loop/lid; other site 41431001927 ABC transporter signature motif; other site 41431001928 Walker B; other site 41431001929 D-loop; other site 41431001930 H-loop/switch region; other site 41431001931 Ferredoxin [Energy production and conversion]; Region: COG1146 41431001932 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 41431001933 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 41431001934 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431001935 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431001936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001937 binding surface 41431001938 TPR motif; other site 41431001939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 41431001940 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431001941 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 41431001942 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431001943 Response regulator receiver domain; Region: Response_reg; pfam00072 41431001944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431001945 active site 41431001946 phosphorylation site [posttranslational modification] 41431001947 intermolecular recognition site; other site 41431001948 dimerization interface [polypeptide binding]; other site 41431001949 Response regulator receiver domain; Region: Response_reg; pfam00072 41431001950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431001951 active site 41431001952 phosphorylation site [posttranslational modification] 41431001953 intermolecular recognition site; other site 41431001954 dimerization interface [polypeptide binding]; other site 41431001955 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 41431001956 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 41431001957 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 41431001958 Helix-turn-helix domains; Region: HTH; cl00088 41431001959 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 41431001960 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 41431001961 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 41431001962 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 41431001963 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 41431001964 active site 41431001965 dimer interface [polypeptide binding]; other site 41431001966 motif 1; other site 41431001967 motif 2; other site 41431001968 motif 3; other site 41431001969 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 41431001970 anticodon binding site; other site 41431001971 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431001972 phosphopeptide binding site; other site 41431001973 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 41431001974 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 41431001975 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431001976 Walker A/P-loop; other site 41431001977 ATP binding site [chemical binding]; other site 41431001978 Q-loop/lid; other site 41431001979 ABC transporter signature motif; other site 41431001980 Walker B; other site 41431001981 D-loop; other site 41431001982 H-loop/switch region; other site 41431001983 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431001984 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431001985 ligand binding site [chemical binding]; other site 41431001986 flexible hinge region; other site 41431001987 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 41431001988 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 41431001989 calmodulin; Provisional; Region: PTZ00184 41431001990 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 41431001991 Ca2+ binding site [ion binding]; other site 41431001992 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 41431001993 Ca2+ binding site [ion binding]; other site 41431001994 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431001995 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 41431001996 cobalt transport protein CbiN; Validated; Region: PRK06287 41431001997 Cobalt transport protein; Region: CbiQ; cl00463 41431001998 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 41431001999 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 41431002000 ligand binding site; other site 41431002001 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 41431002002 active site 41431002003 metal binding site [ion binding]; metal-binding site 41431002004 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 41431002005 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431002006 Walker A/P-loop; other site 41431002007 ATP binding site [chemical binding]; other site 41431002008 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 41431002009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431002010 RNA binding surface [nucleotide binding]; other site 41431002011 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 41431002012 active site 41431002013 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 41431002014 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 41431002015 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 41431002016 NAD(P) binding site [chemical binding]; other site 41431002017 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002018 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431002019 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002020 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002021 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431002022 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 41431002023 HEAT repeat; Region: HEAT; pfam02985 41431002024 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431002025 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 41431002026 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 41431002027 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 41431002028 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 41431002029 cytochrome b subunit interaction site [polypeptide binding]; other site 41431002030 [2Fe-2S] cluster binding site [ion binding]; other site 41431002031 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 41431002032 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 41431002033 dimer interface [polypeptide binding]; other site 41431002034 glycine-pyridoxal phosphate binding site [chemical binding]; other site 41431002035 active site 41431002036 folate binding site [chemical binding]; other site 41431002037 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 41431002038 Response regulator receiver domain; Region: Response_reg; pfam00072 41431002039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002040 active site 41431002041 phosphorylation site [posttranslational modification] 41431002042 intermolecular recognition site; other site 41431002043 dimerization interface [polypeptide binding]; other site 41431002044 CHASE3 domain; Region: CHASE3; cl05000 41431002045 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 41431002046 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431002047 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 41431002048 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431002049 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 41431002050 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431002051 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431002052 putative binding surface; other site 41431002053 active site 41431002054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431002055 ATP binding site [chemical binding]; other site 41431002056 Mg2+ binding site [ion binding]; other site 41431002057 G-X-G motif; other site 41431002058 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431002059 Response regulator receiver domain; Region: Response_reg; pfam00072 41431002060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002061 active site 41431002062 phosphorylation site [posttranslational modification] 41431002063 intermolecular recognition site; other site 41431002064 dimerization interface [polypeptide binding]; other site 41431002065 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 41431002066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002067 active site 41431002068 phosphorylation site [posttranslational modification] 41431002069 intermolecular recognition site; other site 41431002070 dimerization interface [polypeptide binding]; other site 41431002071 CheB methylesterase; Region: CheB_methylest; pfam01339 41431002072 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 41431002073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431002074 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 41431002075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002076 binding surface 41431002077 TPR motif; other site 41431002078 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431002079 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431002080 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 41431002081 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 41431002082 elongation factor G; Reviewed; Region: PRK00007 41431002083 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 41431002084 G1 box; other site 41431002085 putative GEF interaction site [polypeptide binding]; other site 41431002086 GTP/Mg2+ binding site [chemical binding]; other site 41431002087 Switch I region; other site 41431002088 G2 box; other site 41431002089 G3 box; other site 41431002090 Switch II region; other site 41431002091 G4 box; other site 41431002092 G5 box; other site 41431002093 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 41431002094 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 41431002095 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 41431002096 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 41431002097 NodB motif; other site 41431002098 active site 41431002099 catalytic site [active] 41431002100 metal binding site [ion binding]; metal-binding site 41431002101 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 41431002102 MoaE homodimer interface [polypeptide binding]; other site 41431002103 MoaD interaction [polypeptide binding]; other site 41431002104 active site residues [active] 41431002105 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 41431002106 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 41431002107 intersubunit interface [polypeptide binding]; other site 41431002108 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 41431002109 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 41431002110 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 41431002111 ABC-ATPase subunit interface; other site 41431002112 dimer interface [polypeptide binding]; other site 41431002113 putative PBP binding regions; other site 41431002114 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 41431002115 dimer interface [polypeptide binding]; other site 41431002116 active site 41431002117 aspartate-rich active site metal binding site; other site 41431002118 allosteric magnesium binding site [ion binding]; other site 41431002119 Schiff base residues; other site 41431002120 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 41431002121 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431002122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431002123 catalytic residue [active] 41431002124 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 41431002125 active site 41431002126 metal binding site [ion binding]; metal-binding site 41431002127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431002128 S-adenosylmethionine binding site [chemical binding]; other site 41431002129 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 41431002130 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431002131 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 41431002132 active site 41431002133 metal binding site [ion binding]; metal-binding site 41431002134 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002135 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002136 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 41431002137 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431002138 Hexamer interface [polypeptide binding]; other site 41431002139 Hexagonal pore residue; other site 41431002140 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431002141 Hexamer interface [polypeptide binding]; other site 41431002142 Hexagonal pore residue; other site 41431002143 Quinolinate synthetase A protein; Region: NadA; cl00420 41431002144 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 41431002145 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 41431002146 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 41431002147 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 41431002148 P-loop; other site 41431002149 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 41431002150 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 41431002151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431002152 dimerization interface [polypeptide binding]; other site 41431002153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431002154 PAS fold; Region: PAS_3; pfam08447 41431002155 putative active site [active] 41431002156 heme pocket [chemical binding]; other site 41431002157 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 41431002158 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 41431002159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 41431002160 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 41431002161 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 41431002162 putative peptidoglycan binding site; other site 41431002163 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431002164 homoserine dehydrogenase; Provisional; Region: PRK06349 41431002165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002166 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 41431002167 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 41431002168 hydrolase; Region: PLN02578 41431002169 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 41431002170 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 41431002171 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 41431002172 Predicted integral membrane protein [Function unknown]; Region: COG0392 41431002173 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 41431002174 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431002175 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 41431002176 Flavin Reductases; Region: FlaRed; cl00801 41431002177 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 41431002178 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 41431002179 Phycobilisome protein; Region: Phycobilisome; cl08227 41431002180 glutamine synthetase, type I; Region: GlnA; TIGR00653 41431002181 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 41431002182 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 41431002183 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 41431002184 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431002185 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 41431002186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002187 active site 41431002188 phosphorylation site [posttranslational modification] 41431002189 intermolecular recognition site; other site 41431002190 dimerization interface [polypeptide binding]; other site 41431002191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 41431002192 Zn2+ binding site [ion binding]; other site 41431002193 Mg2+ binding site [ion binding]; other site 41431002194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431002195 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 41431002196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002198 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431002199 competence damage-inducible protein A; Provisional; Region: PRK00549 41431002200 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 41431002201 putative MPT binding site; other site 41431002202 Competence-damaged protein; Region: CinA; cl00666 41431002203 SGT1, suppressor of G2 allele of SKP1; Provisional; Region: PLN03088 41431002204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002205 TPR motif; other site 41431002206 binding surface 41431002207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002208 binding surface 41431002209 TPR motif; other site 41431002210 hybrid cluster protein; Provisional; Region: PRK05290 41431002211 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 41431002212 ACS interaction site; other site 41431002213 CODH interaction site; other site 41431002214 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 41431002215 hybrid metal cluster; other site 41431002216 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 41431002217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002219 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 41431002220 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 41431002221 active site 41431002222 substrate binding site [chemical binding]; other site 41431002223 metal binding site [ion binding]; metal-binding site 41431002224 PAS domain S-box; Region: sensory_box; TIGR00229 41431002225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431002226 putative active site [active] 41431002227 heme pocket [chemical binding]; other site 41431002228 GAF domain; Region: GAF; cl00853 41431002229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431002230 dimer interface [polypeptide binding]; other site 41431002231 phosphorylation site [posttranslational modification] 41431002232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431002233 ATP binding site [chemical binding]; other site 41431002234 Mg2+ binding site [ion binding]; other site 41431002235 G-X-G motif; other site 41431002236 Response regulator receiver domain; Region: Response_reg; pfam00072 41431002237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002238 active site 41431002239 phosphorylation site [posttranslational modification] 41431002240 intermolecular recognition site; other site 41431002241 dimerization interface [polypeptide binding]; other site 41431002242 Response regulator receiver domain; Region: Response_reg; pfam00072 41431002243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002244 active site 41431002245 phosphorylation site [posttranslational modification] 41431002246 intermolecular recognition site; other site 41431002247 dimerization interface [polypeptide binding]; other site 41431002248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431002249 metal binding site [ion binding]; metal-binding site 41431002250 active site 41431002251 I-site; other site 41431002252 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431002253 FAD binding domain; Region: FAD_binding_4; pfam01565 41431002254 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 41431002255 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431002256 active site 41431002257 metal binding site [ion binding]; metal-binding site 41431002258 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 41431002259 PEP-CTERM motif; Region: VPEP; cl15443 41431002260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431002261 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 41431002262 Coenzyme A binding pocket [chemical binding]; other site 41431002263 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 41431002264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431002265 Helix-turn-helix domains; Region: HTH; cl00088 41431002266 2-isopropylmalate synthase; Validated; Region: PRK00915 41431002267 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 41431002268 active site 41431002269 catalytic residues [active] 41431002270 metal binding site [ion binding]; metal-binding site 41431002271 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 41431002272 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 41431002273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002274 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 41431002275 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431002276 putative active site [active] 41431002277 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431002278 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431002279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431002280 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431002281 Probable transposase; Region: OrfB_IS605; pfam01385 41431002282 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431002283 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 41431002284 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431002285 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 41431002286 transketolase; Region: PLN02790 41431002287 TPP-binding site [chemical binding]; other site 41431002288 dimer interface [polypeptide binding]; other site 41431002289 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 41431002290 PYR/PP interface [polypeptide binding]; other site 41431002291 dimer interface [polypeptide binding]; other site 41431002292 TPP binding site [chemical binding]; other site 41431002293 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 41431002294 glycogen synthase; Provisional; Region: glgA; PRK00654 41431002295 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 41431002296 ADP-binding pocket [chemical binding]; other site 41431002297 homodimer interface [polypeptide binding]; other site 41431002298 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 41431002299 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 41431002300 active site 41431002301 interdomain interaction site; other site 41431002302 putative metal-binding site [ion binding]; other site 41431002303 nucleotide binding site [chemical binding]; other site 41431002304 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 41431002305 domain I; other site 41431002306 phosphate binding site [ion binding]; other site 41431002307 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 41431002308 domain II; other site 41431002309 domain III; other site 41431002310 nucleotide binding site [chemical binding]; other site 41431002311 DNA binding groove [nucleotide binding] 41431002312 catalytic site [active] 41431002313 domain IV; other site 41431002314 light-harvesting-like protein 3; Provisional; Region: PLN00014 41431002315 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431002316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002317 active site 41431002318 phosphorylation site [posttranslational modification] 41431002319 intermolecular recognition site; other site 41431002320 dimerization interface [polypeptide binding]; other site 41431002321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431002322 metal binding site [ion binding]; metal-binding site 41431002323 active site 41431002324 I-site; other site 41431002325 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431002326 Photosystem I protein M (PsaM); Region: PsaM; cl15374 41431002327 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431002328 YcfA-like protein; Region: YcfA; cl00752 41431002329 SelR domain; Region: SelR; cl00369 41431002330 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 41431002331 C-terminal domain interface [polypeptide binding]; other site 41431002332 GSH binding site (G-site) [chemical binding]; other site 41431002333 dimer interface [polypeptide binding]; other site 41431002334 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 41431002335 N-terminal domain interface [polypeptide binding]; other site 41431002336 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 41431002337 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 41431002338 dimer interface [polypeptide binding]; other site 41431002339 putative anticodon binding site; other site 41431002340 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 41431002341 motif 1; other site 41431002342 active site 41431002343 motif 2; other site 41431002344 motif 3; other site 41431002345 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431002346 active site 41431002347 ATP binding site [chemical binding]; other site 41431002348 substrate binding site [chemical binding]; other site 41431002349 activation loop (A-loop); other site 41431002350 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431002351 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002352 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002353 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 41431002354 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 41431002355 active site 41431002356 Zn binding site [ion binding]; other site 41431002357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 41431002358 dimerization interface [polypeptide binding]; other site 41431002359 putative DNA binding site [nucleotide binding]; other site 41431002360 putative Zn2+ binding site [ion binding]; other site 41431002361 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 41431002362 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 41431002363 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 41431002364 P-loop, Walker A motif; other site 41431002365 Base recognition motif; other site 41431002366 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 41431002367 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 41431002368 structural tetrad; other site 41431002369 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 41431002370 homodecamer interface [polypeptide binding]; other site 41431002371 GTP cyclohydrolase I; Provisional; Region: PLN03044 41431002372 active site 41431002373 putative catalytic site residues [active] 41431002374 zinc binding site [ion binding]; other site 41431002375 GTP-CH-I/GFRP interaction surface; other site 41431002376 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 41431002377 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431002378 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 41431002379 Hydrogenase formation hypA family; Region: HypD; cl12072 41431002380 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 41431002381 Fe-S metabolism associated domain; Region: SufE; cl00951 41431002382 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 41431002383 putative active site [active] 41431002384 putative metal binding site [ion binding]; other site 41431002385 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 41431002386 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 41431002387 metal binding site 2 [ion binding]; metal-binding site 41431002388 putative DNA binding helix; other site 41431002389 metal binding site 1 [ion binding]; metal-binding site 41431002390 dimer interface [polypeptide binding]; other site 41431002391 structural Zn2+ binding site [ion binding]; other site 41431002392 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 41431002393 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 41431002394 acyl-ACP reductase; Provisional; Region: PRK14982 41431002395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002396 NAD(P) binding pocket [chemical binding]; other site 41431002397 WAX2 C-terminal domain; Region: Wax2_C; pfam12076 41431002398 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 41431002399 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 41431002400 Helix-turn-helix domains; Region: HTH; cl00088 41431002401 DNA-binding site [nucleotide binding]; DNA binding site 41431002402 HrcA protein C terminal domain; Region: HrcA; pfam01628 41431002403 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 41431002404 active site residue [active] 41431002405 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 41431002406 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431002407 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431002408 Probable transposase; Region: OrfB_IS605; pfam01385 41431002409 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431002410 Gram-negative bacterial tonB protein; Region: TonB; cl10048 41431002411 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 41431002412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002413 binding surface 41431002414 TPR motif; other site 41431002415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002416 binding surface 41431002417 TPR motif; other site 41431002418 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 41431002419 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431002420 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431002421 catalytic residue [active] 41431002422 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 41431002423 putative active site [active] 41431002424 putative metal binding site [ion binding]; other site 41431002425 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 41431002426 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 41431002427 substrate binding site [chemical binding]; other site 41431002428 ATP binding site [chemical binding]; other site 41431002429 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 41431002430 MatE; Region: MatE; cl10513 41431002431 MatE; Region: MatE; cl10513 41431002432 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431002433 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431002434 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431002435 ligand binding site [chemical binding]; other site 41431002436 flexible hinge region; other site 41431002437 Helix-turn-helix domains; Region: HTH; cl00088 41431002438 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 41431002439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 41431002440 ABC-ATPase subunit interface; other site 41431002441 dimer interface [polypeptide binding]; other site 41431002442 putative PBP binding regions; other site 41431002443 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431002444 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 41431002445 NAD binding site [chemical binding]; other site 41431002446 putative substrate binding site 2 [chemical binding]; other site 41431002447 putative substrate binding site 1 [chemical binding]; other site 41431002448 active site 41431002449 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 41431002450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002451 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 41431002452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002453 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 41431002454 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 41431002455 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 41431002456 Phosphotransferase enzyme family; Region: APH; pfam01636 41431002457 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 41431002458 active site 41431002459 ATP binding site [chemical binding]; other site 41431002460 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 41431002461 substrate binding site [chemical binding]; other site 41431002462 alanine racemase; Reviewed; Region: alr; PRK00053 41431002463 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 41431002464 active site 41431002465 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 41431002466 dimer interface [polypeptide binding]; other site 41431002467 substrate binding site [chemical binding]; other site 41431002468 catalytic residues [active] 41431002469 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431002470 RHS Repeat; Region: RHS_repeat; cl11982 41431002471 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 41431002472 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 41431002473 PYR/PP interface [polypeptide binding]; other site 41431002474 dimer interface [polypeptide binding]; other site 41431002475 TPP binding site [chemical binding]; other site 41431002476 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 41431002477 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 41431002478 TPP-binding site [chemical binding]; other site 41431002479 dimer interface [polypeptide binding]; other site 41431002480 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 41431002481 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431002482 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431002483 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 41431002484 Probable Catalytic site; other site 41431002485 metal-binding site 41431002486 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 41431002487 Probable Catalytic site; other site 41431002488 metal-binding site 41431002489 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 41431002490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002491 NAD(P) binding site [chemical binding]; other site 41431002492 active site 41431002493 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 41431002494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431002495 S-adenosylmethionine binding site [chemical binding]; other site 41431002496 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 41431002497 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 41431002498 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 41431002499 classical (c) SDRs; Region: SDR_c; cd05233 41431002500 NAD(P) binding site [chemical binding]; other site 41431002501 active site 41431002502 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 41431002503 homodecamer interface [polypeptide binding]; other site 41431002504 GTP cyclohydrolase I; Provisional; Region: PLN03044 41431002505 active site 41431002506 putative catalytic site residues [active] 41431002507 zinc binding site [ion binding]; other site 41431002508 GTP-CH-I/GFRP interaction surface; other site 41431002509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 41431002510 FIST N domain; Region: FIST; cl10701 41431002511 FIST C domain; Region: FIST_C; pfam10442 41431002512 CP12 domain; Region: CP12; cl14670 41431002513 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 41431002514 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 41431002515 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 41431002516 putative ligand binding site [chemical binding]; other site 41431002517 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 41431002518 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 41431002519 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 41431002520 active site 41431002521 putative substrate binding region [chemical binding]; other site 41431002522 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 41431002523 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 41431002524 hydrolase; Region: PLN02578 41431002525 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431002526 ScpA/B protein; Region: ScpA_ScpB; cl00598 41431002527 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 41431002528 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 41431002529 active site 41431002530 Substrate binding site; other site 41431002531 Mg++ binding site; other site 41431002532 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 41431002533 putative trimer interface [polypeptide binding]; other site 41431002534 putative CoA binding site [chemical binding]; other site 41431002535 PAS fold; Region: PAS_4; pfam08448 41431002536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 41431002537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431002538 metal binding site [ion binding]; metal-binding site 41431002539 active site 41431002540 I-site; other site 41431002541 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 41431002542 CheC-like family; Region: CheC; pfam04509 41431002543 Response regulator receiver domain; Region: Response_reg; pfam00072 41431002544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002545 active site 41431002546 phosphorylation site [posttranslational modification] 41431002547 intermolecular recognition site; other site 41431002548 dimerization interface [polypeptide binding]; other site 41431002549 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431002550 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431002551 active site 41431002552 ATP binding site [chemical binding]; other site 41431002553 substrate binding site [chemical binding]; other site 41431002554 activation loop (A-loop); other site 41431002555 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 41431002556 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 41431002557 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 41431002558 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 41431002559 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431002560 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 41431002561 TIR domain; Region: TIR; cl02060 41431002562 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431002563 structural tetrad; other site 41431002564 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431002565 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431002566 structural tetrad; other site 41431002567 mercuric reductase; Validated; Region: PRK06370 41431002568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002569 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 41431002570 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 41431002571 Walker A/P-loop; other site 41431002572 ATP binding site [chemical binding]; other site 41431002573 Q-loop/lid; other site 41431002574 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 41431002575 ABC transporter signature motif; other site 41431002576 Walker B; other site 41431002577 D-loop; other site 41431002578 H-loop/switch region; other site 41431002579 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 41431002580 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 41431002581 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 41431002582 Walker A/P-loop; other site 41431002583 ATP binding site [chemical binding]; other site 41431002584 Q-loop/lid; other site 41431002585 ABC transporter signature motif; other site 41431002586 Walker B; other site 41431002587 D-loop; other site 41431002588 H-loop/switch region; other site 41431002589 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 41431002590 alanine--tRNA ligase; Region: alaS; TIGR00344 41431002591 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 41431002592 oligomer interface [polypeptide binding]; other site 41431002593 active site residues [active] 41431002594 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 41431002595 oligomer interface [polypeptide binding]; other site 41431002596 active site residues [active] 41431002597 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431002598 recombinase A; Provisional; Region: recA; PRK09354 41431002599 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 41431002600 hexamer interface [polypeptide binding]; other site 41431002601 Walker A motif; other site 41431002602 ATP binding site [chemical binding]; other site 41431002603 Walker B motif; other site 41431002604 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 41431002605 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 41431002606 Zn binding site [ion binding]; other site 41431002607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431002608 S-adenosylmethionine binding site [chemical binding]; other site 41431002609 TM2 domain; Region: TM2; cl00984 41431002610 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 41431002611 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 41431002612 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 41431002613 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002614 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002615 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 41431002616 shikimate kinase; Reviewed; Region: aroK; PRK00131 41431002617 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 41431002618 ADP binding site [chemical binding]; other site 41431002619 magnesium binding site [ion binding]; other site 41431002620 putative shikimate binding site; other site 41431002621 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 41431002622 Clp amino terminal domain; Region: Clp_N; pfam02861 41431002623 Clp amino terminal domain; Region: Clp_N; pfam02861 41431002624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431002625 Walker A motif; other site 41431002626 ATP binding site [chemical binding]; other site 41431002627 Walker B motif; other site 41431002628 arginine finger; other site 41431002629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431002630 Walker A motif; other site 41431002631 ATP binding site [chemical binding]; other site 41431002632 Walker B motif; other site 41431002633 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 41431002634 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 41431002635 IHF - DNA interface [nucleotide binding]; other site 41431002636 IHF dimer interface [polypeptide binding]; other site 41431002637 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 41431002638 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 41431002639 proposed catalytic triad [active] 41431002640 active site nucleophile [active] 41431002641 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 41431002642 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431002643 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431002644 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 41431002645 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431002646 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431002647 putative active site [active] 41431002648 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 41431002649 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 41431002650 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431002651 GAF domain; Region: GAF; cl00853 41431002652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431002653 dimer interface [polypeptide binding]; other site 41431002654 phosphorylation site [posttranslational modification] 41431002655 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 41431002656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002657 binding surface 41431002658 TPR motif; other site 41431002659 hypothetical protein; Provisional; Region: PRK08185 41431002660 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 41431002661 intersubunit interface [polypeptide binding]; other site 41431002662 active site 41431002663 zinc binding site [ion binding]; other site 41431002664 Na+ binding site [ion binding]; other site 41431002665 EamA-like transporter family; Region: EamA; cl01037 41431002666 EamA-like transporter family; Region: EamA; cl01037 41431002667 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 41431002668 heterotetramer interface [polypeptide binding]; other site 41431002669 active site pocket [active] 41431002670 cleavage site 41431002671 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 41431002672 putative acyl-acceptor binding pocket; other site 41431002673 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 41431002674 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 41431002675 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 41431002676 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 41431002677 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 41431002678 active site 41431002679 zinc binding site [ion binding]; other site 41431002680 Uncharacterized conserved protein [Function unknown]; Region: COG2898 41431002681 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 41431002682 Predicted integral membrane protein [Function unknown]; Region: COG0392 41431002683 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 41431002684 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431002685 Putative esterase; Region: Esterase; pfam00756 41431002686 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 41431002687 chaperone protein DnaJ; Provisional; Region: PRK14299 41431002688 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431002689 HSP70 interaction site [polypeptide binding]; other site 41431002690 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 41431002691 dimer interface [polypeptide binding]; other site 41431002692 molecular chaperone DnaK; Provisional; Region: PRK13410 41431002693 agmatine deiminase; Region: agmatine_aguA; TIGR03380 41431002694 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 41431002695 N-carbamolyputrescine amidase; Region: PLN02747 41431002696 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 41431002697 putative active site; other site 41431002698 catalytic triad [active] 41431002699 putative dimer interface [polypeptide binding]; other site 41431002700 gamma-glutamyl kinase; Provisional; Region: PRK05429 41431002701 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 41431002702 nucleotide binding site [chemical binding]; other site 41431002703 homotetrameric interface [polypeptide binding]; other site 41431002704 putative phosphate binding site [ion binding]; other site 41431002705 putative allosteric binding site; other site 41431002706 PUA domain; Region: PUA; cl00607 41431002707 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 41431002708 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 41431002709 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 41431002710 putative phosphate binding site [ion binding]; other site 41431002711 putative catalytic site [active] 41431002712 active site 41431002713 metal binding site A [ion binding]; metal-binding site 41431002714 DNA binding site [nucleotide binding] 41431002715 putative AP binding site [nucleotide binding]; other site 41431002716 putative metal binding site B [ion binding]; other site 41431002717 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 41431002718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431002719 cofactor binding site; other site 41431002720 DNA binding site [nucleotide binding] 41431002721 substrate interaction site [chemical binding]; other site 41431002722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431002723 ketol-acid reductoisomerase; Provisional; Region: PRK05479 41431002724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002725 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 41431002726 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 41431002727 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431002728 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 41431002729 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 41431002730 putative substrate binding site [chemical binding]; other site 41431002731 putative ATP binding site [chemical binding]; other site 41431002732 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 41431002733 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431002734 putative active site [active] 41431002735 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 41431002736 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 41431002737 dimer interface [polypeptide binding]; other site 41431002738 tetramer interface [polypeptide binding]; other site 41431002739 PYR/PP interface [polypeptide binding]; other site 41431002740 TPP binding site [chemical binding]; other site 41431002741 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 41431002742 TPP-binding site; other site 41431002743 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 41431002744 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 41431002745 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 41431002746 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 41431002747 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 41431002748 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 41431002749 putative ligand binding site [chemical binding]; other site 41431002750 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431002751 dimerization interface [polypeptide binding]; other site 41431002752 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431002753 PAS fold; Region: PAS_3; pfam08447 41431002754 putative active site [active] 41431002755 heme pocket [chemical binding]; other site 41431002756 chromosome segregation protein; Provisional; Region: PRK03918 41431002757 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 41431002758 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 41431002759 Fasciclin domain; Region: Fasciclin; cl02663 41431002760 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 41431002761 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 41431002762 B12 binding site [chemical binding]; other site 41431002763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431002764 FeS/SAM binding site; other site 41431002765 NADH dehydrogenase; Region: NADHdh; cl00469 41431002766 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 41431002767 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 41431002768 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 41431002769 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 41431002770 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 41431002771 Fasciclin domain; Region: Fasciclin; cl02663 41431002772 DNA polymerase III subunit beta; Validated; Region: PRK05643 41431002773 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 41431002774 putative DNA binding surface [nucleotide binding]; other site 41431002775 dimer interface [polypeptide binding]; other site 41431002776 beta-clamp/clamp loader binding surface; other site 41431002777 beta-clamp/translesion DNA polymerase binding surface; other site 41431002778 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 41431002779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431002780 Walker A/P-loop; other site 41431002781 ATP binding site [chemical binding]; other site 41431002782 Q-loop/lid; other site 41431002783 ABC transporter signature motif; other site 41431002784 Walker B; other site 41431002785 D-loop; other site 41431002786 H-loop/switch region; other site 41431002787 ABC-2 type transporter; Region: ABC2_membrane; cl11417 41431002788 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; cl15400 41431002789 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 41431002790 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 41431002791 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 41431002792 Walker A/P-loop; other site 41431002793 ATP binding site [chemical binding]; other site 41431002794 Q-loop/lid; other site 41431002795 ABC transporter signature motif; other site 41431002796 Walker B; other site 41431002797 D-loop; other site 41431002798 H-loop/switch region; other site 41431002799 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 41431002800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431002801 dimer interface [polypeptide binding]; other site 41431002802 conserved gate region; other site 41431002803 putative PBP binding loops; other site 41431002804 ABC-ATPase subunit interface; other site 41431002805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431002806 dimer interface [polypeptide binding]; other site 41431002807 conserved gate region; other site 41431002808 putative PBP binding loops; other site 41431002809 ABC-ATPase subunit interface; other site 41431002810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 41431002811 threonine synthase; Reviewed; Region: PRK06721 41431002812 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 41431002813 homodimer interface [polypeptide binding]; other site 41431002814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431002815 catalytic residue [active] 41431002816 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431002817 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431002818 Magnesium ion binding site [ion binding]; other site 41431002819 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 41431002820 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 41431002821 active site 41431002822 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 41431002823 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 41431002824 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431002825 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 41431002826 Walker A/P-loop; other site 41431002827 ATP binding site [chemical binding]; other site 41431002828 Q-loop/lid; other site 41431002829 ABC transporter signature motif; other site 41431002830 Walker B; other site 41431002831 D-loop; other site 41431002832 H-loop/switch region; other site 41431002833 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431002834 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 41431002835 putative ADP-binding pocket [chemical binding]; other site 41431002836 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431002837 putative active site [active] 41431002838 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 41431002839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431002840 ATP binding site [chemical binding]; other site 41431002841 putative Mg++ binding site [ion binding]; other site 41431002842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431002843 nucleotide binding region [chemical binding]; other site 41431002844 ATP-binding site [chemical binding]; other site 41431002845 RQC domain; Region: RQC; cl09632 41431002846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 41431002847 HRDC domain; Region: HRDC; cl02578 41431002848 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 41431002849 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 41431002850 hinge; other site 41431002851 active site 41431002852 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431002853 Putative esterase; Region: Esterase; pfam00756 41431002854 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 41431002855 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 41431002856 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 41431002857 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 41431002858 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 41431002859 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 41431002860 active site 41431002861 catalytic site [active] 41431002862 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 41431002863 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 41431002864 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431002865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002866 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 41431002867 integral membrane protein MviN; Region: mviN; TIGR01695 41431002868 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 41431002869 RNA/DNA binding site [nucleotide binding]; other site 41431002870 RRM dimerization site [polypeptide binding]; other site 41431002871 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 41431002872 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 41431002873 Heme NO binding; Region: HNOB; cl15268 41431002874 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 41431002875 Heme NO binding; Region: HNOB; cl15268 41431002876 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 41431002877 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 41431002878 Phycobilisome protein; Region: Phycobilisome; cl08227 41431002879 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431002880 catalytic loop [active] 41431002881 iron binding site [ion binding]; other site 41431002882 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 41431002883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002884 binding surface 41431002885 TPR motif; other site 41431002886 Restriction endonuclease; Region: Mrr_cat; cl00747 41431002887 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431002888 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 41431002889 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431002890 catalytic residue [active] 41431002891 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 41431002892 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 41431002893 homodimer interface [polypeptide binding]; other site 41431002894 oligonucleotide binding site [chemical binding]; other site 41431002895 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 41431002896 RNA/DNA hybrid binding site [nucleotide binding]; other site 41431002897 active site 41431002898 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 41431002899 prephenate dehydratase; Provisional; Region: PRK11898 41431002900 Prephenate dehydratase; Region: PDT; pfam00800 41431002901 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 41431002902 putative L-Phe binding site [chemical binding]; other site 41431002903 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 41431002904 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 41431002905 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 41431002906 putative active site [active] 41431002907 catalytic site [active] 41431002908 putative metal binding site [ion binding]; other site 41431002909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 41431002910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 41431002911 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431002912 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 41431002913 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431002914 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 41431002915 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431002916 nucleotide binding region [chemical binding]; other site 41431002917 tocopherol cyclase; Region: PLN02818 41431002918 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 41431002919 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 41431002920 Pantoate-beta-alanine ligase; Region: PanC; cd00560 41431002921 active site 41431002922 ATP-binding site [chemical binding]; other site 41431002923 pantoate-binding site; other site 41431002924 HXXH motif; other site 41431002925 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 41431002926 CMP-binding site; other site 41431002927 The sites determining sugar specificity; other site 41431002928 yiaA/B two helix domain; Region: YiaAB; cl01759 41431002929 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 41431002930 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 41431002931 substrate binding site [chemical binding]; other site 41431002932 ATP binding site [chemical binding]; other site 41431002933 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 41431002934 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 41431002935 Predicted esterase [General function prediction only]; Region: COG0627 41431002936 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431002937 FOG: WD40-like repeat [Function unknown]; Region: COG1520 41431002938 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 41431002939 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 41431002940 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 41431002941 GIY-YIG motif/motif A; other site 41431002942 active site 41431002943 catalytic site [active] 41431002944 putative DNA binding site [nucleotide binding]; other site 41431002945 metal binding site [ion binding]; metal-binding site 41431002946 UvrB/uvrC motif; Region: UVR; pfam02151 41431002947 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 41431002948 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 41431002949 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 41431002950 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 41431002951 Walker A/P-loop; other site 41431002952 ATP binding site [chemical binding]; other site 41431002953 Q-loop/lid; other site 41431002954 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431002955 ABC transporter signature motif; other site 41431002956 Walker B; other site 41431002957 D-loop; other site 41431002958 H-loop/switch region; other site 41431002959 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 41431002960 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 41431002961 tandem repeat interface [polypeptide binding]; other site 41431002962 oligomer interface [polypeptide binding]; other site 41431002963 active site residues [active] 41431002964 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 41431002965 tandem repeat interface [polypeptide binding]; other site 41431002966 oligomer interface [polypeptide binding]; other site 41431002967 active site residues [active] 41431002968 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 41431002969 active site 41431002970 catalytic triad [active] 41431002971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431002972 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431002973 Probable transposase; Region: OrfB_IS605; pfam01385 41431002974 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431002975 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 41431002976 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431002977 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431002978 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 41431002979 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 41431002980 active site 41431002981 substrate binding site [chemical binding]; other site 41431002982 cosubstrate binding site; other site 41431002983 catalytic site [active] 41431002984 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 41431002985 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 41431002986 iron-sulfur cluster [ion binding]; other site 41431002987 [2Fe-2S] cluster binding site [ion binding]; other site 41431002988 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 41431002989 Protein of unknown function (DUF760); Region: DUF760; pfam05542 41431002990 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431002991 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431002992 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 41431002993 Cytochrome P450; Region: p450; cl12078 41431002994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 41431002995 Cupin domain; Region: Cupin_2; cl09118 41431002996 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 41431002997 catalytic triad [active] 41431002998 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 41431002999 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 41431003000 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 41431003001 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 41431003002 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 41431003003 putative active site [active] 41431003004 catalytic site [active] 41431003005 putative substrate binding site [chemical binding]; other site 41431003006 NifU-like domain; Region: NifU; cl00484 41431003007 Domain of unknown function (DUF307); Region: DUF307; pfam03733 41431003008 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 41431003009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431003010 dimer interface [polypeptide binding]; other site 41431003011 conserved gate region; other site 41431003012 ABC-ATPase subunit interface; other site 41431003013 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 41431003014 methionine aminopeptidase; Provisional; Region: PRK08671 41431003015 active site 41431003016 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 41431003017 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 41431003018 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 41431003019 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 41431003020 protein binding site [polypeptide binding]; other site 41431003021 glycogen synthase; Provisional; Region: glgA; PRK00654 41431003022 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 41431003023 ADP-binding pocket [chemical binding]; other site 41431003024 homodimer interface [polypeptide binding]; other site 41431003025 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 41431003026 catalytic residues [active] 41431003027 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 41431003028 feedback inhibition sensing region; other site 41431003029 homohexameric interface [polypeptide binding]; other site 41431003030 nucleotide binding site [chemical binding]; other site 41431003031 N-acetyl-L-glutamate binding site [chemical binding]; other site 41431003032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003033 binding surface 41431003034 TPR motif; other site 41431003035 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 41431003036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431003037 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 41431003038 serine O-acetyltransferase; Region: cysE; TIGR01172 41431003039 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 41431003040 trimer interface [polypeptide binding]; other site 41431003041 active site 41431003042 substrate binding site [chemical binding]; other site 41431003043 CoA binding site [chemical binding]; other site 41431003044 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 41431003045 isoform II; Region: PAF-AH_p_II; pfam03403 41431003046 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 41431003047 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 41431003048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431003049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431003050 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 41431003051 substrate binding pocket [chemical binding]; other site 41431003052 membrane-bound complex binding site; other site 41431003053 hinge residues; other site 41431003054 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003056 active site 41431003057 phosphorylation site [posttranslational modification] 41431003058 intermolecular recognition site; other site 41431003059 dimerization interface [polypeptide binding]; other site 41431003060 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431003061 metal binding site [ion binding]; metal-binding site 41431003062 active site 41431003063 I-site; other site 41431003064 Membrane transport protein; Region: Mem_trans; cl09117 41431003065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 41431003066 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 41431003067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003068 PAS fold; Region: PAS_3; pfam08447 41431003069 putative active site [active] 41431003070 heme pocket [chemical binding]; other site 41431003071 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 41431003072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431003073 dimer interface [polypeptide binding]; other site 41431003074 phosphorylation site [posttranslational modification] 41431003075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003076 ATP binding site [chemical binding]; other site 41431003077 Mg2+ binding site [ion binding]; other site 41431003078 G-X-G motif; other site 41431003079 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003081 active site 41431003082 phosphorylation site [posttranslational modification] 41431003083 intermolecular recognition site; other site 41431003084 dimerization interface [polypeptide binding]; other site 41431003085 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 41431003086 aspartate kinase; Provisional; Region: PRK07431 41431003087 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 41431003088 putative catalytic residues [active] 41431003089 putative nucleotide binding site [chemical binding]; other site 41431003090 putative aspartate binding site [chemical binding]; other site 41431003091 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 41431003092 putative allosteric regulatory site; other site 41431003093 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 41431003094 putative allosteric regulatory residue; other site 41431003095 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 41431003096 putative allosteric regulatory site; other site 41431003097 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 41431003098 putative allosteric regulatory residue; other site 41431003099 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 41431003100 Cupin domain; Region: Cupin_2; cl09118 41431003101 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 41431003102 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 41431003103 active site 41431003104 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431003105 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431003106 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431003107 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 41431003108 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 41431003109 metal-binding site 41431003110 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431003111 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 41431003112 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431003113 putative active site [active] 41431003114 putative metal binding site [ion binding]; other site 41431003115 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 41431003116 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 41431003117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431003118 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431003119 Probable transposase; Region: OrfB_IS605; pfam01385 41431003120 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431003121 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 41431003122 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 41431003123 GatB domain; Region: GatB_Yqey; cl11497 41431003124 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 41431003125 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 41431003126 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431003127 ligand binding site [chemical binding]; other site 41431003128 flexible hinge region; other site 41431003129 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 41431003130 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 41431003131 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 41431003132 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 41431003133 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 41431003134 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 41431003135 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 41431003136 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 41431003137 amidohydrolase; Region: amidohydrolases; TIGR01891 41431003138 metal binding site [ion binding]; metal-binding site 41431003139 dimer interface [polypeptide binding]; other site 41431003140 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 41431003141 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 41431003142 dimer interface [polypeptide binding]; other site 41431003143 active site 41431003144 recombination protein RecR; Reviewed; Region: recR; PRK00076 41431003145 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 41431003146 RecR protein; Region: RecR; pfam02132 41431003147 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 41431003148 putative active site [active] 41431003149 putative metal-binding site [ion binding]; other site 41431003150 tetramer interface [polypeptide binding]; other site 41431003151 Probable transposase; Region: OrfB_IS605; pfam01385 41431003152 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431003153 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 41431003154 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 41431003155 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 41431003156 dimer interface [polypeptide binding]; other site 41431003157 motif 1; other site 41431003158 active site 41431003159 motif 2; other site 41431003160 motif 3; other site 41431003161 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 41431003162 anticodon binding site; other site 41431003163 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003164 putative active site [active] 41431003165 glycerol kinase; Region: glycerol_kin; TIGR01311 41431003166 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 41431003167 N- and C-terminal domain interface [polypeptide binding]; other site 41431003168 active site 41431003169 MgATP binding site [chemical binding]; other site 41431003170 catalytic site [active] 41431003171 metal binding site [ion binding]; metal-binding site 41431003172 glycerol binding site [chemical binding]; other site 41431003173 homotetramer interface [polypeptide binding]; other site 41431003174 homodimer interface [polypeptide binding]; other site 41431003175 FBP binding site [chemical binding]; other site 41431003176 protein IIAGlc interface [polypeptide binding]; other site 41431003177 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 41431003178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003179 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 41431003180 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 41431003181 ring oligomerisation interface [polypeptide binding]; other site 41431003182 ATP/Mg binding site [chemical binding]; other site 41431003183 stacking interactions; other site 41431003184 hinge regions; other site 41431003185 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 41431003186 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 41431003187 DNA binding residues [nucleotide binding] 41431003188 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 41431003189 catalytic residues [active] 41431003190 catalytic nucleophile [active] 41431003191 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 41431003192 Predicted amidohydrolase [General function prediction only]; Region: COG0388 41431003193 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 41431003194 putative active site [active] 41431003195 catalytic triad [active] 41431003196 dimer interface [polypeptide binding]; other site 41431003197 aspartate aminotransferase; Provisional; Region: PRK05957 41431003198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431003199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431003200 homodimer interface [polypeptide binding]; other site 41431003201 catalytic residue [active] 41431003202 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431003203 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003204 putative active site [active] 41431003205 PemK-like protein; Region: PemK; cl00995 41431003206 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 41431003207 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 41431003208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431003209 Walker A motif; other site 41431003210 ATP binding site [chemical binding]; other site 41431003211 Walker B motif; other site 41431003212 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 41431003213 RxxxH motif; other site 41431003214 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 41431003215 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 41431003216 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431003217 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 41431003218 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 41431003219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003220 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431003221 catalytic loop [active] 41431003222 iron binding site [ion binding]; other site 41431003223 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431003224 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 41431003225 O-succinylbenzoate synthase; Provisional; Region: PRK02714 41431003226 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 41431003227 active site 41431003228 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 41431003229 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431003230 Psb28 protein; Region: Psb28; cl04326 41431003231 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 41431003232 MPT binding site; other site 41431003233 trimer interface [polypeptide binding]; other site 41431003234 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 41431003235 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 41431003236 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 41431003237 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 41431003238 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431003239 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 41431003240 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 41431003241 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431003242 active site 41431003243 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 41431003244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003245 binding surface 41431003246 TPR motif; other site 41431003247 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 41431003248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003249 binding surface 41431003250 TPR motif; other site 41431003251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003252 binding surface 41431003253 TPR motif; other site 41431003254 Ribosome-binding factor A; Region: RBFA; cl00542 41431003255 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 41431003256 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 41431003257 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 41431003258 Lumazine binding domain; Region: Lum_binding; pfam00677 41431003259 Lumazine binding domain; Region: Lum_binding; pfam00677 41431003260 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431003261 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 41431003262 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 41431003263 Phycobilisome protein; Region: Phycobilisome; cl08227 41431003264 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 41431003265 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 41431003266 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 41431003267 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 41431003268 catalytic motif [active] 41431003269 Zn binding site [ion binding]; other site 41431003270 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 41431003271 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 41431003272 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 41431003273 E3 interaction surface; other site 41431003274 lipoyl attachment site [posttranslational modification]; other site 41431003275 e3 binding domain; Region: E3_binding; pfam02817 41431003276 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 41431003277 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 41431003278 putative active site [active] 41431003279 dimerization interface [polypeptide binding]; other site 41431003280 putative tRNAtyr binding site [nucleotide binding]; other site 41431003281 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 41431003282 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 41431003283 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 41431003284 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003286 active site 41431003287 phosphorylation site [posttranslational modification] 41431003288 intermolecular recognition site; other site 41431003289 dimerization interface [polypeptide binding]; other site 41431003290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003291 NAD(P) binding site [chemical binding]; other site 41431003292 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 41431003293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003294 active site 41431003295 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431003296 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 41431003297 protein I interface; other site 41431003298 D2 interface; other site 41431003299 protein T interface; other site 41431003300 chlorophyll binding site; other site 41431003301 beta carotene binding site; other site 41431003302 pheophytin binding site; other site 41431003303 manganese-stabilizing polypeptide interface; other site 41431003304 CP43 interface; other site 41431003305 protein L interface; other site 41431003306 oxygen evolving complex binding site; other site 41431003307 bromide binding site; other site 41431003308 quinone binding site; other site 41431003309 Fe binding site [ion binding]; other site 41431003310 core light harvesting interface; other site 41431003311 cytochrome b559 alpha subunit interface; other site 41431003312 cytochrome c-550 interface; other site 41431003313 protein J interface; other site 41431003314 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003315 putative active site [active] 41431003316 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 41431003317 catalytic motif [active] 41431003318 Zn binding site [ion binding]; other site 41431003319 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 41431003320 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 41431003321 trimer interface [polypeptide binding]; other site 41431003322 active site 41431003323 Tetrahydromethanopterin S-methyltransferase, subunit A; Region: MtrA; cl04449 41431003324 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 41431003325 dimerization interface [polypeptide binding]; other site 41431003326 active site 41431003327 dihydropteroate synthase-related protein; Region: TIGR00284 41431003328 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431003329 Domain of unknown function (DUF897); Region: DUF897; cl01312 41431003330 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 41431003331 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 41431003332 TMP-binding site; other site 41431003333 ATP-binding site [chemical binding]; other site 41431003334 NifU-like domain; Region: NifU; cl00484 41431003335 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 41431003336 iron-sulfur cluster [ion binding]; other site 41431003337 [2Fe-2S] cluster binding site [ion binding]; other site 41431003338 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003339 putative active site [active] 41431003340 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431003341 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431003342 P-loop; other site 41431003343 Magnesium ion binding site [ion binding]; other site 41431003344 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431003345 Magnesium ion binding site [ion binding]; other site 41431003346 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 41431003347 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 41431003348 THUMP domain; Region: THUMP; cl12076 41431003349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431003350 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 41431003351 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 41431003352 YCII-related domain; Region: YCII; cl00999 41431003353 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431003354 GAF domain; Region: GAF; cl00853 41431003355 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431003356 GAF domain; Region: GAF; cl00853 41431003357 cyclase homology domain; Region: CHD; cd07302 41431003358 nucleotidyl binding site; other site 41431003359 metal binding site [ion binding]; metal-binding site 41431003360 dimer interface [polypeptide binding]; other site 41431003361 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431003362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431003363 Coenzyme A binding pocket [chemical binding]; other site 41431003364 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 41431003365 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 41431003366 putative ligand binding site [chemical binding]; other site 41431003367 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 41431003368 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 41431003369 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431003370 Walker A motif; other site 41431003371 ATP binding site [chemical binding]; other site 41431003372 Walker B motif; other site 41431003373 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 41431003374 lipoyl attachment site [posttranslational modification]; other site 41431003375 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003376 putative active site [active] 41431003377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003378 PAS fold; Region: PAS_3; pfam08447 41431003379 putative active site [active] 41431003380 heme pocket [chemical binding]; other site 41431003381 PAS fold; Region: PAS_4; pfam08448 41431003382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003383 putative active site [active] 41431003384 heme pocket [chemical binding]; other site 41431003385 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431003386 GAF domain; Region: GAF; cl00853 41431003387 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 41431003388 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003389 putative active site [active] 41431003390 heme pocket [chemical binding]; other site 41431003391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431003392 dimer interface [polypeptide binding]; other site 41431003393 phosphorylation site [posttranslational modification] 41431003394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003395 ATP binding site [chemical binding]; other site 41431003396 Mg2+ binding site [ion binding]; other site 41431003397 G-X-G motif; other site 41431003398 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003400 active site 41431003401 phosphorylation site [posttranslational modification] 41431003402 intermolecular recognition site; other site 41431003403 dimerization interface [polypeptide binding]; other site 41431003404 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 41431003405 putative acyl-acceptor binding pocket; other site 41431003406 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 41431003407 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431003408 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431003409 Magnesium ion binding site [ion binding]; other site 41431003410 photosystem I subunit VII; Region: psaC; CHL00065 41431003411 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 41431003412 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 41431003413 DHH family; Region: DHH; pfam01368 41431003414 DHHA1 domain; Region: DHHA1; pfam02272 41431003415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431003416 Walker B; other site 41431003417 D-loop; other site 41431003418 H-loop/switch region; other site 41431003419 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 41431003420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003421 Mg2+ binding site [ion binding]; other site 41431003422 G-X-G motif; other site 41431003423 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 41431003424 anchoring element; other site 41431003425 dimer interface [polypeptide binding]; other site 41431003426 ATP binding site [chemical binding]; other site 41431003427 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 41431003428 active site 41431003429 putative metal-binding site [ion binding]; other site 41431003430 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 41431003431 stage V sporulation protein K; Region: spore_V_K; TIGR02881 41431003432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431003433 Walker A motif; other site 41431003434 ATP binding site [chemical binding]; other site 41431003435 Walker B motif; other site 41431003436 arginine finger; other site 41431003437 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 41431003438 O-Antigen ligase; Region: Wzy_C; cl04850 41431003439 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 41431003440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431003441 ATP binding site [chemical binding]; other site 41431003442 putative Mg++ binding site [ion binding]; other site 41431003443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431003444 nucleotide binding region [chemical binding]; other site 41431003445 ATP-binding site [chemical binding]; other site 41431003446 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 41431003447 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 41431003448 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 41431003449 RNA binding site [nucleotide binding]; other site 41431003450 active site 41431003451 UTRA domain; Region: UTRA; cl01230 41431003452 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 41431003453 DHH family; Region: DHH; pfam01368 41431003454 Uncharacterized conserved protein [Function unknown]; Region: COG1912 41431003455 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 41431003456 RNA methyltransferase, RsmE family; Region: TIGR00046 41431003457 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 41431003458 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 41431003459 Flagellar hook capping protein; Region: FlgD; cl04347 41431003460 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431003461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003462 binding surface 41431003463 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 41431003464 TPR motif; other site 41431003465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003466 binding surface 41431003467 TPR motif; other site 41431003468 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 41431003469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003470 TPR motif; other site 41431003471 binding surface 41431003472 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 41431003473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003474 binding surface 41431003475 TPR motif; other site 41431003476 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 41431003477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003478 binding surface 41431003479 TPR motif; other site 41431003480 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 41431003481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003482 binding surface 41431003483 TPR motif; other site 41431003484 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 41431003485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003486 binding surface 41431003487 TPR motif; other site 41431003488 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 41431003489 Conserved TM helix; Region: TM_helix; pfam05552 41431003490 Conserved TM helix; Region: TM_helix; pfam05552 41431003491 Conserved TM helix; Region: TM_helix; pfam05552 41431003492 adaptive-response sensory kinase; Validated; Region: PRK09303 41431003493 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 41431003494 tetramer interface [polypeptide binding]; other site 41431003495 dimer interface [polypeptide binding]; other site 41431003496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431003497 dimer interface [polypeptide binding]; other site 41431003498 phosphorylation site [posttranslational modification] 41431003499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003500 ATP binding site [chemical binding]; other site 41431003501 Mg2+ binding site [ion binding]; other site 41431003502 G-X-G motif; other site 41431003503 Uncharacterized conserved protein [Function unknown]; Region: COG1543 41431003504 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 41431003505 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 41431003506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003507 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 41431003508 iron-sulfur cluster [ion binding]; other site 41431003509 [2Fe-2S] cluster binding site [ion binding]; other site 41431003510 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 41431003511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 41431003513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003514 ATP binding site [chemical binding]; other site 41431003515 Mg2+ binding site [ion binding]; other site 41431003516 G-X-G motif; other site 41431003517 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 41431003518 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 41431003519 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431003520 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 41431003521 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 41431003522 Domain of unknown function (DUF477); Region: DUF477; cl01535 41431003523 proton translocating ATP synthase, F1 alpha subunit; Region: atpA; TIGR00962 41431003524 YtxH-like protein; Region: YtxH; cl02079 41431003525 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 41431003526 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 41431003527 purine monophosphate binding site [chemical binding]; other site 41431003528 dimer interface [polypeptide binding]; other site 41431003529 putative catalytic residues [active] 41431003530 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 41431003531 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 41431003532 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003533 putative active site [active] 41431003534 Cupin domain; Region: Cupin_2; cl09118 41431003535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003536 NAD(P) binding site [chemical binding]; other site 41431003537 active site 41431003538 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431003539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003540 NAD(P) binding site [chemical binding]; other site 41431003541 active site 41431003542 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003543 putative active site [active] 41431003544 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 41431003545 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 41431003546 G1 box; other site 41431003547 GTP/Mg2+ binding site [chemical binding]; other site 41431003548 Switch I region; other site 41431003549 G2 box; other site 41431003550 Switch II region; other site 41431003551 G3 box; other site 41431003552 G4 box; other site 41431003553 G5 box; other site 41431003554 Domain of unknown function (DUF697); Region: DUF697; cl12064 41431003555 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 41431003556 RNA/DNA hybrid binding site [nucleotide binding]; other site 41431003557 active site 41431003558 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 41431003559 DNA-binding site [nucleotide binding]; DNA binding site 41431003560 RNA-binding motif; other site 41431003561 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 41431003562 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 41431003563 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 41431003564 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 41431003565 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431003566 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431003567 active site 41431003568 ATP binding site [chemical binding]; other site 41431003569 substrate binding site [chemical binding]; other site 41431003570 activation loop (A-loop); other site 41431003571 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 41431003572 Zn binding site [ion binding]; other site 41431003573 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G_bact; cd04170 41431003574 elongation factor G; Reviewed; Region: PRK12740 41431003575 G1 box; other site 41431003576 putative GEF interaction site [polypeptide binding]; other site 41431003577 GTP/Mg2+ binding site [chemical binding]; other site 41431003578 Switch I region; other site 41431003579 G2 box; other site 41431003580 G3 box; other site 41431003581 Switch II region; other site 41431003582 G4 box; other site 41431003583 G5 box; other site 41431003584 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 41431003585 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 41431003586 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 41431003587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431003588 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431003589 Probable transposase; Region: OrfB_IS605; pfam01385 41431003590 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431003591 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431003592 Transglycosylase; Region: Transgly; cl07896 41431003593 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 41431003594 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 41431003595 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 41431003596 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 41431003597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431003598 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431003599 Probable transposase; Region: OrfB_IS605; pfam01385 41431003600 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431003601 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431003602 GAF domain; Region: GAF; cl00853 41431003603 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431003604 phosphopeptide binding site; other site 41431003605 PAS domain S-box; Region: sensory_box; TIGR00229 41431003606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003607 putative active site [active] 41431003608 heme pocket [chemical binding]; other site 41431003609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431003610 metal binding site [ion binding]; metal-binding site 41431003611 active site 41431003612 I-site; other site 41431003613 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431003614 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 41431003615 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 41431003616 PAS domain S-box; Region: sensory_box; TIGR00229 41431003617 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003618 putative active site [active] 41431003619 heme pocket [chemical binding]; other site 41431003620 hypothetical protein; Provisional; Region: PRK13560 41431003621 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003622 putative active site [active] 41431003623 heme pocket [chemical binding]; other site 41431003624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003625 putative active site [active] 41431003626 heme pocket [chemical binding]; other site 41431003627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003628 putative active site [active] 41431003629 heme pocket [chemical binding]; other site 41431003630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003631 putative active site [active] 41431003632 heme pocket [chemical binding]; other site 41431003633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431003634 dimer interface [polypeptide binding]; other site 41431003635 phosphorylation site [posttranslational modification] 41431003636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003637 ATP binding site [chemical binding]; other site 41431003638 Mg2+ binding site [ion binding]; other site 41431003639 G-X-G motif; other site 41431003640 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003642 active site 41431003643 phosphorylation site [posttranslational modification] 41431003644 intermolecular recognition site; other site 41431003645 dimerization interface [polypeptide binding]; other site 41431003646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003647 active site 41431003648 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 41431003649 phosphorylation site [posttranslational modification] 41431003650 intermolecular recognition site; other site 41431003651 dimerization interface [polypeptide binding]; other site 41431003652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003653 putative active site [active] 41431003654 heme pocket [chemical binding]; other site 41431003655 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431003656 metal binding site [ion binding]; metal-binding site 41431003657 active site 41431003658 I-site; other site 41431003659 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431003660 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 41431003661 pseudouridine synthase; Region: TIGR00093 41431003662 active site 41431003663 CpeS-like protein; Region: CpeS; pfam09367 41431003664 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431003665 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 41431003666 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 41431003667 dimer interface [polypeptide binding]; other site 41431003668 motif 1; other site 41431003669 active site 41431003670 motif 2; other site 41431003671 motif 3; other site 41431003672 O-Antigen ligase; Region: Wzy_C; cl04850 41431003673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003674 binding surface 41431003675 TPR motif; other site 41431003676 Cytochrome P450; Region: p450; cl12078 41431003677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431003678 Coenzyme A binding pocket [chemical binding]; other site 41431003679 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 41431003680 DNA gyrase, A subunit; Region: gyrA; TIGR01063 41431003681 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 41431003682 CAP-like domain; other site 41431003683 active site 41431003684 primary dimer interface [polypeptide binding]; other site 41431003685 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431003686 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431003687 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003689 active site 41431003690 phosphorylation site [posttranslational modification] 41431003691 intermolecular recognition site; other site 41431003692 dimerization interface [polypeptide binding]; other site 41431003693 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 41431003694 Stage II sporulation protein; Region: SpoIID; pfam08486 41431003695 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431003696 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431003697 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 41431003698 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 41431003699 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 41431003700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003701 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 41431003702 active site 41431003703 dimerization interface [polypeptide binding]; other site 41431003704 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 41431003705 MltA specific insert domain; Region: MltA; cl08398 41431003706 3D domain; Region: 3D; cl01439 41431003707 MoxR-like ATPases [General function prediction only]; Region: COG0714 41431003708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431003709 Walker A motif; other site 41431003710 ATP binding site [chemical binding]; other site 41431003711 Walker B motif; other site 41431003712 arginine finger; other site 41431003713 Cytochrome c; Region: Cytochrom_C; cl11414 41431003714 Dihaem cytochrome c; Region: DHC; pfam09626 41431003715 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 41431003716 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 41431003717 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003718 putative active site [active] 41431003719 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 41431003720 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 41431003721 putative active site [active] 41431003722 catalytic triad [active] 41431003723 putative dimer interface [polypeptide binding]; other site 41431003724 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431003725 catalytic core [active] 41431003726 citrate synthase; Provisional; Region: PRK14036 41431003727 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 41431003728 dimer interface [polypeptide binding]; other site 41431003729 active site 41431003730 citrylCoA binding site [chemical binding]; other site 41431003731 oxalacetate/citrate binding site [chemical binding]; other site 41431003732 coenzyme A binding site [chemical binding]; other site 41431003733 catalytic triad [active] 41431003734 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431003735 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 41431003736 heme binding pocket [chemical binding]; other site 41431003737 heme ligand [chemical binding]; other site 41431003738 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431003739 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 41431003740 CpeS-like protein; Region: CpeS; pfam09367 41431003741 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 41431003742 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431003743 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003744 putative active site [active] 41431003745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431003746 S-adenosylmethionine binding site [chemical binding]; other site 41431003747 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431003748 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 41431003749 putative C-terminal domain interface [polypeptide binding]; other site 41431003750 putative GSH binding site (G-site) [chemical binding]; other site 41431003751 putative dimer interface [polypeptide binding]; other site 41431003752 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 41431003753 N-terminal domain interface [polypeptide binding]; other site 41431003754 dimer interface [polypeptide binding]; other site 41431003755 substrate binding pocket (H-site) [chemical binding]; other site 41431003756 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 41431003757 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 41431003758 catalytic residues [active] 41431003759 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 41431003760 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003761 putative active site [active] 41431003762 Domain of unknown function (DUF364); Region: DUF364; cl00885 41431003763 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 41431003764 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 41431003765 Haemolysin XhlA; Region: XhlA; pfam10779 41431003766 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431003767 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 41431003768 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 41431003769 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 41431003770 catalytic site [active] 41431003771 active site 41431003772 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 41431003773 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 41431003774 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 41431003775 active site 41431003776 catalytic site [active] 41431003777 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 41431003778 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 41431003779 Phosphate-starvation-inducible E; Region: PsiE; cl01264 41431003780 putative transposase; Provisional; Region: PHA02942 41431003781 Probable transposase; Region: OrfB_IS605; pfam01385 41431003782 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431003783 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431003784 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 41431003785 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 41431003786 putative active site [active] 41431003787 putative NTP binding site [chemical binding]; other site 41431003788 putative nucleic acid binding site [nucleotide binding]; other site 41431003789 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 41431003790 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431003791 active site 41431003792 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 41431003793 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 41431003794 putative active site [active] 41431003795 putative NTP binding site [chemical binding]; other site 41431003796 putative nucleic acid binding site [nucleotide binding]; other site 41431003797 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 41431003798 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431003799 active site 41431003800 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 41431003801 Cytomegalovirus IE1 protein; Region: Herpes_IE1; pfam07340 41431003802 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 41431003803 G1 box; other site 41431003804 GTP/Mg2+ binding site [chemical binding]; other site 41431003805 Switch I region; other site 41431003806 G2 box; other site 41431003807 Switch II region; other site 41431003808 G3 box; other site 41431003809 G4 box; other site 41431003810 G5 box; other site 41431003811 Domain of unknown function (DUF697); Region: DUF697; cl12064 41431003812 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 41431003813 Domain of unknown function (DUF389); Region: DUF389; cl00781 41431003814 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 41431003815 active site 41431003816 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431003817 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 41431003818 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 41431003819 FAD binding domain; Region: FAD_binding_4; pfam01565 41431003820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431003821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431003822 dimer interface [polypeptide binding]; other site 41431003823 phosphorylation site [posttranslational modification] 41431003824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003825 ATP binding site [chemical binding]; other site 41431003826 Mg2+ binding site [ion binding]; other site 41431003827 G-X-G motif; other site 41431003828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431003829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003830 active site 41431003831 phosphorylation site [posttranslational modification] 41431003832 intermolecular recognition site; other site 41431003833 dimerization interface [polypeptide binding]; other site 41431003834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431003835 DNA binding site [nucleotide binding] 41431003836 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 41431003837 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431003838 Clp protease ATP binding subunit; Region: clpC; CHL00095 41431003839 Clp amino terminal domain; Region: Clp_N; pfam02861 41431003840 Clp amino terminal domain; Region: Clp_N; pfam02861 41431003841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431003842 Walker A motif; other site 41431003843 ATP binding site [chemical binding]; other site 41431003844 Walker B motif; other site 41431003845 arginine finger; other site 41431003846 UvrB/uvrC motif; Region: UVR; pfam02151 41431003847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431003848 Walker A motif; other site 41431003849 ATP binding site [chemical binding]; other site 41431003850 Walker B motif; other site 41431003851 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 41431003852 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 41431003853 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 41431003854 motif 1; other site 41431003855 active site 41431003856 motif 2; other site 41431003857 motif 3; other site 41431003858 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 41431003859 putative acyl transferase; Provisional; Region: PRK10502 41431003860 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 41431003861 putative trimer interface [polypeptide binding]; other site 41431003862 putative active site [active] 41431003863 putative substrate binding site [chemical binding]; other site 41431003864 putative CoA binding site [chemical binding]; other site 41431003865 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 41431003866 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431003867 putative metal binding site; other site 41431003868 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 41431003869 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 41431003870 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431003871 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 41431003872 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 41431003873 putative active site [active] 41431003874 Phd_YefM; Region: PhdYeFM; cl09153 41431003875 TIR domain; Region: TIR; cl02060 41431003876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 41431003877 PAS fold; Region: PAS_3; pfam08447 41431003878 PAS fold; Region: PAS_3; pfam08447 41431003879 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 41431003880 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431003881 GAF domain; Region: GAF; cl00853 41431003882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431003883 metal binding site [ion binding]; metal-binding site 41431003884 active site 41431003885 I-site; other site 41431003886 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 41431003887 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 41431003888 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 41431003889 synthetase active site [active] 41431003890 NTP binding site [chemical binding]; other site 41431003891 metal binding site [ion binding]; metal-binding site 41431003892 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 41431003893 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 41431003894 CrcB-like protein; Region: CRCB; cl09114 41431003895 Glutaminase; Region: Glutaminase; cl00907 41431003896 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 41431003897 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431003898 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 41431003899 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 41431003900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431003901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003902 TPR motif; other site 41431003903 binding surface 41431003904 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431003905 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 41431003906 catalytic center binding site [active] 41431003907 ATP binding site [chemical binding]; other site 41431003908 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 41431003909 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 41431003910 dimer interface [polypeptide binding]; other site 41431003911 ADP-ribose binding site [chemical binding]; other site 41431003912 active site 41431003913 nudix motif; other site 41431003914 metal binding site [ion binding]; metal-binding site 41431003915 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 41431003916 DNA photolyase; Region: DNA_photolyase; pfam00875 41431003917 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 41431003918 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 41431003919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15367 41431003920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 41431003921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 41431003922 S-layer homology domain; Region: SLH; pfam00395 41431003923 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 41431003924 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 41431003925 FeoA domain; Region: FeoA; cl00838 41431003926 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431003927 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431003928 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 41431003929 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 41431003930 putative NAD(P) binding site [chemical binding]; other site 41431003931 putative substrate binding site [chemical binding]; other site 41431003932 catalytic Zn binding site [ion binding]; other site 41431003933 structural Zn binding site [ion binding]; other site 41431003934 dimer interface [polypeptide binding]; other site 41431003935 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; cl02342 41431003936 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 41431003937 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 41431003938 putative RNA binding site [nucleotide binding]; other site 41431003939 Protein of unknown function (DUF502); Region: DUF502; cl01107 41431003940 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 41431003941 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 41431003942 putative active site [active] 41431003943 Double zinc ribbon; Region: DZR; pfam12773 41431003944 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 41431003945 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431003946 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431003947 phosphopeptide binding site; other site 41431003948 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 41431003949 active site 41431003950 putative substrate binding region [chemical binding]; other site 41431003951 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 41431003952 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 41431003953 classical (c) SDRs; Region: SDR_c; cd05233 41431003954 NAD(P) binding site [chemical binding]; other site 41431003955 active site 41431003956 Predicted ATPase [General function prediction only]; Region: COG4637 41431003957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431003958 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 41431003959 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 41431003960 Walker A/P-loop; other site 41431003961 ATP binding site [chemical binding]; other site 41431003962 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 41431003963 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 41431003964 ABC transporter signature motif; other site 41431003965 Walker B; other site 41431003966 D-loop; other site 41431003967 H-loop/switch region; other site 41431003968 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 41431003969 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431003970 substrate binding pocket [chemical binding]; other site 41431003971 membrane-bound complex binding site; other site 41431003972 hinge residues; other site 41431003973 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 41431003974 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431003975 FeS/SAM binding site; other site 41431003976 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 41431003977 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431003978 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 41431003979 active site 41431003980 Stress responsive A/B Barrel Domain; Region: Dabb; cl06768 41431003981 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 41431003982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431003983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431003984 homodimer interface [polypeptide binding]; other site 41431003985 catalytic residue [active] 41431003986 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 41431003987 Helix-turn-helix domains; Region: HTH; cl00088 41431003988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431003989 two component system sensor kinase SsrA; Provisional; Region: PRK15347 41431003990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431003991 dimer interface [polypeptide binding]; other site 41431003992 phosphorylation site [posttranslational modification] 41431003993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003994 ATP binding site [chemical binding]; other site 41431003995 Mg2+ binding site [ion binding]; other site 41431003996 G-X-G motif; other site 41431003997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003998 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003999 active site 41431004000 phosphorylation site [posttranslational modification] 41431004001 intermolecular recognition site; other site 41431004002 dimerization interface [polypeptide binding]; other site 41431004003 Response regulator receiver domain; Region: Response_reg; pfam00072 41431004004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004005 active site 41431004006 phosphorylation site [posttranslational modification] 41431004007 intermolecular recognition site; other site 41431004008 dimerization interface [polypeptide binding]; other site 41431004009 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 41431004010 Response regulator receiver domain; Region: Response_reg; pfam00072 41431004011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004012 active site 41431004013 phosphorylation site [posttranslational modification] 41431004014 intermolecular recognition site; other site 41431004015 dimerization interface [polypeptide binding]; other site 41431004016 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431004017 GAF domain; Region: GAF; cl00853 41431004018 Predicted integral membrane protein [Function unknown]; Region: COG0392 41431004019 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 41431004020 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 41431004021 Precorrin-8X methylmutase; Region: CbiC; pfam02570 41431004022 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 41431004023 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 41431004024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431004025 Predicted permease; Region: DUF318; cl00487 41431004026 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 41431004027 Response regulator receiver domain; Region: Response_reg; pfam00072 41431004028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004029 active site 41431004030 phosphorylation site [posttranslational modification] 41431004031 intermolecular recognition site; other site 41431004032 dimerization interface [polypeptide binding]; other site 41431004033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004034 dimer interface [polypeptide binding]; other site 41431004035 phosphorylation site [posttranslational modification] 41431004036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004037 ATP binding site [chemical binding]; other site 41431004038 Mg2+ binding site [ion binding]; other site 41431004039 G-X-G motif; other site 41431004040 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 41431004041 GAF domain; Region: GAF; cl00853 41431004042 Phytochrome region; Region: PHY; pfam00360 41431004043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004044 dimer interface [polypeptide binding]; other site 41431004045 phosphorylation site [posttranslational modification] 41431004046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004047 ATP binding site [chemical binding]; other site 41431004048 Mg2+ binding site [ion binding]; other site 41431004049 G-X-G motif; other site 41431004050 Response regulator receiver domain; Region: Response_reg; pfam00072 41431004051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004052 active site 41431004053 phosphorylation site [posttranslational modification] 41431004054 intermolecular recognition site; other site 41431004055 dimerization interface [polypeptide binding]; other site 41431004056 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 41431004057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431004058 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431004059 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 41431004060 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 41431004061 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 41431004062 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 41431004063 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 41431004064 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 41431004065 substrate binding site [chemical binding]; other site 41431004066 active site 41431004067 catalytic residues [active] 41431004068 heterodimer interface [polypeptide binding]; other site 41431004069 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 41431004070 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 41431004071 dimer interface [polypeptide binding]; other site 41431004072 decamer (pentamer of dimers) interface [polypeptide binding]; other site 41431004073 catalytic triad [active] 41431004074 peroxidatic and resolving cysteines [active] 41431004075 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 41431004076 active site 41431004077 putative DNA-binding cleft [nucleotide binding]; other site 41431004078 dimer interface [polypeptide binding]; other site 41431004079 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431004080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004081 active site 41431004082 phosphorylation site [posttranslational modification] 41431004083 intermolecular recognition site; other site 41431004084 dimerization interface [polypeptide binding]; other site 41431004085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004086 dimer interface [polypeptide binding]; other site 41431004087 phosphorylation site [posttranslational modification] 41431004088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004089 ATP binding site [chemical binding]; other site 41431004090 G-X-G motif; other site 41431004091 Cupin domain; Region: Cupin_2; cl09118 41431004092 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 41431004093 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 41431004094 generic binding surface II; other site 41431004095 ssDNA binding site; other site 41431004096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431004097 ATP binding site [chemical binding]; other site 41431004098 putative Mg++ binding site [ion binding]; other site 41431004099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431004100 nucleotide binding region [chemical binding]; other site 41431004101 ATP-binding site [chemical binding]; other site 41431004102 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 41431004103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431004104 S-adenosylmethionine binding site [chemical binding]; other site 41431004105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431004106 S-adenosylmethionine binding site [chemical binding]; other site 41431004107 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004108 putative active site [active] 41431004109 phosphodiesterase; Provisional; Region: PRK12704 41431004110 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 41431004111 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 41431004112 putative active site [active] 41431004113 oxyanion strand; other site 41431004114 catalytic triad [active] 41431004115 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 41431004116 putative substrate binding pocket [chemical binding]; other site 41431004117 catalytic triad [active] 41431004118 AB domain interface; other site 41431004119 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 41431004120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431004121 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431004122 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 41431004123 Chain length determinant protein; Region: Wzz; cl01623 41431004124 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 41431004125 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 41431004126 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 41431004127 SLBB domain; Region: SLBB; pfam10531 41431004128 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 41431004129 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 41431004130 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 41431004131 Rubrerythrin [Energy production and conversion]; Region: COG1592 41431004132 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 41431004133 binuclear metal center [ion binding]; other site 41431004134 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 41431004135 iron binding site [ion binding]; other site 41431004136 YcfA-like protein; Region: YcfA; cl00752 41431004137 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431004138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431004139 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431004140 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 41431004141 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 41431004142 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 41431004143 trimer interface [polypeptide binding]; other site 41431004144 active site 41431004145 UDP-GlcNAc binding site [chemical binding]; other site 41431004146 lipid binding site [chemical binding]; lipid-binding site 41431004147 Exoribonuclease R [Transcription]; Region: VacB; COG0557 41431004148 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 41431004149 RNB domain; Region: RNB; pfam00773 41431004150 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 41431004151 RNA binding site [nucleotide binding]; other site 41431004152 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 41431004153 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 41431004154 chorismate binding enzyme; Region: Chorismate_bind; cl10555 41431004155 UbiA prenyltransferase family; Region: UbiA; cl00337 41431004156 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 41431004157 Domain of unknown function (DUF309); Region: DUF309; cl00667 41431004158 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 41431004159 RNA/DNA binding site [nucleotide binding]; other site 41431004160 RRM dimerization site [polypeptide binding]; other site 41431004161 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431004162 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 41431004163 NAD(P) binding site [chemical binding]; other site 41431004164 catalytic residues [active] 41431004165 Probable transposase; Region: OrfB_IS605; pfam01385 41431004166 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431004167 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431004168 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431004169 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 41431004170 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 41431004171 iron-sulfur cluster [ion binding]; other site 41431004172 [2Fe-2S] cluster binding site [ion binding]; other site 41431004173 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 41431004174 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 41431004175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431004176 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 41431004177 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 41431004178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431004179 ATP binding site [chemical binding]; other site 41431004180 putative Mg++ binding site [ion binding]; other site 41431004181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431004182 nucleotide binding region [chemical binding]; other site 41431004183 ATP-binding site [chemical binding]; other site 41431004184 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 41431004185 homotrimer interaction site [polypeptide binding]; other site 41431004186 putative active site [active] 41431004187 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 41431004188 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 41431004189 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 41431004190 elongation factor Tu; Region: tufA; CHL00071 41431004191 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 41431004192 G1 box; other site 41431004193 GEF interaction site [polypeptide binding]; other site 41431004194 GTP/Mg2+ binding site [chemical binding]; other site 41431004195 Switch I region; other site 41431004196 G2 box; other site 41431004197 G3 box; other site 41431004198 Switch II region; other site 41431004199 G4 box; other site 41431004200 G5 box; other site 41431004201 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 41431004202 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 41431004203 Antibiotic Binding Site [chemical binding]; other site 41431004204 elongation factor G; Reviewed; Region: PRK00007 41431004205 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 41431004206 G1 box; other site 41431004207 putative GEF interaction site [polypeptide binding]; other site 41431004208 GTP/Mg2+ binding site [chemical binding]; other site 41431004209 Switch I region; other site 41431004210 G2 box; other site 41431004211 G3 box; other site 41431004212 Switch II region; other site 41431004213 G4 box; other site 41431004214 G5 box; other site 41431004215 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 41431004216 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 41431004217 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 41431004218 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 41431004219 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 41431004220 S17 interaction site [polypeptide binding]; other site 41431004221 S8 interaction site; other site 41431004222 16S rRNA interaction site [nucleotide binding]; other site 41431004223 streptomycin interaction site [chemical binding]; other site 41431004224 23S rRNA interaction site [nucleotide binding]; other site 41431004225 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 41431004226 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 41431004227 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 41431004228 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 41431004229 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 41431004230 catalytic residue [active] 41431004231 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431004232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004233 active site 41431004234 phosphorylation site [posttranslational modification] 41431004235 intermolecular recognition site; other site 41431004236 dimerization interface [polypeptide binding]; other site 41431004237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431004238 DNA binding site [nucleotide binding] 41431004239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004240 dimer interface [polypeptide binding]; other site 41431004241 phosphorylation site [posttranslational modification] 41431004242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004243 ATP binding site [chemical binding]; other site 41431004244 Mg2+ binding site [ion binding]; other site 41431004245 G-X-G motif; other site 41431004246 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 41431004247 homotrimer interface [polypeptide binding]; other site 41431004248 Walker A motif; other site 41431004249 GTP binding site [chemical binding]; other site 41431004250 Walker B motif; other site 41431004251 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 41431004252 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 41431004253 putative active site [active] 41431004254 substrate binding site [chemical binding]; other site 41431004255 putative cosubstrate binding site; other site 41431004256 catalytic site [active] 41431004257 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 41431004258 substrate binding site [chemical binding]; other site 41431004259 DNA polymerase III subunit delta'; Validated; Region: PRK07399 41431004260 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431004261 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431004262 phosphopeptide binding site; other site 41431004263 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431004264 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 41431004265 active site 41431004266 metal binding site [ion binding]; metal-binding site 41431004267 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 41431004268 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 41431004269 metal-binding site [ion binding] 41431004270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431004271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431004272 active site 41431004273 motif I; other site 41431004274 motif II; other site 41431004275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431004276 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 41431004277 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431004278 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 41431004279 Helix-turn-helix domains; Region: HTH; cl00088 41431004280 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 41431004281 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431004282 RNA binding surface [nucleotide binding]; other site 41431004283 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 41431004284 active site 41431004285 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 41431004286 dimer interface [polypeptide binding]; other site 41431004287 active site 41431004288 Schiff base residues; other site 41431004289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004290 binding surface 41431004291 TPR motif; other site 41431004292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431004293 binding surface 41431004294 TPR motif; other site 41431004295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004296 TPR motif; other site 41431004297 binding surface 41431004298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004299 binding surface 41431004300 TPR motif; other site 41431004301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004302 TPR motif; other site 41431004303 binding surface 41431004304 CHAT domain; Region: CHAT; cl02083 41431004305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004306 binding surface 41431004307 TPR motif; other site 41431004308 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431004309 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 41431004310 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 41431004311 anti sigma factor interaction site; other site 41431004312 regulatory phosphorylation site [posttranslational modification]; other site 41431004313 Bacterial sugar transferase; Region: Bac_transf; cl00939 41431004314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 41431004315 Protein of unknown function (DUF721); Region: DUF721; cl02324 41431004316 flavoprotein, HI0933 family; Region: TIGR00275 41431004317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431004318 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 41431004319 classical (c) SDRs; Region: SDR_c; cd05233 41431004320 NAD(P) binding site [chemical binding]; other site 41431004321 active site 41431004322 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 41431004323 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 41431004324 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 41431004325 intersubunit interface [polypeptide binding]; other site 41431004326 active site 41431004327 Zn2+ binding site [ion binding]; other site 41431004328 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 41431004329 TM-ABC transporter signature motif; other site 41431004330 response regulator FixJ; Provisional; Region: fixJ; PRK09390 41431004331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004332 active site 41431004333 phosphorylation site [posttranslational modification] 41431004334 intermolecular recognition site; other site 41431004335 dimerization interface [polypeptide binding]; other site 41431004336 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431004337 DNA binding residues [nucleotide binding] 41431004338 dimerization interface [polypeptide binding]; other site 41431004339 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 41431004340 dimer interface [polypeptide binding]; other site 41431004341 [2Fe-2S] cluster binding site [ion binding]; other site 41431004342 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 41431004343 putative lipid kinase; Reviewed; Region: PRK13057 41431004344 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 41431004345 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 41431004346 Ligand Binding Site [chemical binding]; other site 41431004347 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431004348 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 41431004349 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431004350 GAF domain; Region: GAF; cl00853 41431004351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004352 dimer interface [polypeptide binding]; other site 41431004353 phosphorylation site [posttranslational modification] 41431004354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004355 ATP binding site [chemical binding]; other site 41431004356 Mg2+ binding site [ion binding]; other site 41431004357 G-X-G motif; other site 41431004358 ABC-2 type transporter; Region: ABC2_membrane; cl11417 41431004359 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 41431004360 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 41431004361 C-terminal peptidase (prc); Region: prc; TIGR00225 41431004362 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 41431004363 protein binding site [polypeptide binding]; other site 41431004364 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 41431004365 Catalytic dyad [active] 41431004366 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 41431004367 nudix motif; other site 41431004368 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 41431004369 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 41431004370 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 41431004371 homodimer interface [polypeptide binding]; other site 41431004372 NADP binding site [chemical binding]; other site 41431004373 substrate binding site [chemical binding]; other site 41431004374 Protein of unknown function (DUF563); Region: DUF563; cl15705 41431004375 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 41431004376 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 41431004377 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 41431004378 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 41431004379 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431004380 Hexamer interface [polypeptide binding]; other site 41431004381 Hexagonal pore residue; other site 41431004382 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431004383 Hexamer interface [polypeptide binding]; other site 41431004384 Hexagonal pore residue; other site 41431004385 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 41431004386 Hexamer/Pentamer interface [polypeptide binding]; other site 41431004387 central pore; other site 41431004388 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 41431004389 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 41431004390 trimer interface [polypeptide binding]; other site 41431004391 active site 41431004392 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 41431004393 putative multimerization interface [polypeptide binding]; other site 41431004394 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 41431004395 putative multimerization interface [polypeptide binding]; other site 41431004396 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 41431004397 putative multimerization interface [polypeptide binding]; other site 41431004398 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 41431004399 putative multimerization interface [polypeptide binding]; other site 41431004400 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 41431004401 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004402 putative active site [active] 41431004403 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 41431004404 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 41431004405 homodimer interface [polypeptide binding]; other site 41431004406 active site 41431004407 heterodimer interface [polypeptide binding]; other site 41431004408 catalytic residue [active] 41431004409 metal binding site [ion binding]; metal-binding site 41431004410 RbcX protein; Region: RcbX; pfam02341 41431004411 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 41431004412 multimerization interface [polypeptide binding]; other site 41431004413 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 41431004414 oligomeric interface; other site 41431004415 putative active site [active] 41431004416 homodimer interface [polypeptide binding]; other site 41431004417 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 41431004418 alanine dehydrogenase; Region: alaDH; TIGR00518 41431004419 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 41431004420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431004421 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 41431004422 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 41431004423 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 41431004424 Walker A motif; other site 41431004425 ATP binding site [chemical binding]; other site 41431004426 Walker B motif; other site 41431004427 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 41431004428 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 41431004429 Walker A motif; other site 41431004430 ATP binding site [chemical binding]; other site 41431004431 Walker B motif; other site 41431004432 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 41431004433 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 41431004434 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 41431004435 Uncharacterized conserved protein [Function unknown]; Region: COG2006 41431004436 Domain of unknown function (DUF362); Region: DUF362; pfam04015 41431004437 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431004438 short chain dehydrogenase; Provisional; Region: PRK12828 41431004439 classical (c) SDRs; Region: SDR_c; cd05233 41431004440 NAD(P) binding site [chemical binding]; other site 41431004441 active site 41431004442 muropeptide transporter; Reviewed; Region: ampG; PRK11902 41431004443 muropeptide transporter; Validated; Region: ampG; PRK11010 41431004444 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 41431004445 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 41431004446 substrate binding site [chemical binding]; other site 41431004447 hexamer interface [polypeptide binding]; other site 41431004448 metal binding site [ion binding]; metal-binding site 41431004449 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004450 putative active site [active] 41431004451 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 41431004452 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 41431004453 Fatty acid desaturase; Region: FA_desaturase; pfam00487 41431004454 putative di-iron ligands [ion binding]; other site 41431004455 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 41431004456 polyphosphate kinase; Provisional; Region: PRK05443 41431004457 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 41431004458 putative domain interface [polypeptide binding]; other site 41431004459 putative active site [active] 41431004460 catalytic site [active] 41431004461 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 41431004462 putative domain interface [polypeptide binding]; other site 41431004463 putative active site [active] 41431004464 catalytic site [active] 41431004465 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431004466 catalytic loop [active] 41431004467 iron binding site [ion binding]; other site 41431004468 cobyric acid synthase; Provisional; Region: PRK00784 41431004469 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431004470 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431004471 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 41431004472 catalytic triad [active] 41431004473 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 41431004474 catalytic triad [active] 41431004475 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431004476 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 41431004477 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 41431004478 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 41431004479 Substrate binding site; other site 41431004480 Mg++ binding site; other site 41431004481 metal-binding site 41431004482 Mg++ binding site; other site 41431004483 metal-binding site 41431004484 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 41431004485 Tetramer interface [polypeptide binding]; other site 41431004486 active site 41431004487 FMN-binding site [chemical binding]; other site 41431004488 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431004489 phosphopeptide binding site; other site 41431004490 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431004491 phosphopeptide binding site; other site 41431004492 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 41431004493 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 41431004494 Walker A/P-loop; other site 41431004495 ATP binding site [chemical binding]; other site 41431004496 Q-loop/lid; other site 41431004497 ABC transporter signature motif; other site 41431004498 Walker B; other site 41431004499 D-loop; other site 41431004500 H-loop/switch region; other site 41431004501 ferredoxin-sulfite reductase; Region: sir; TIGR02042 41431004502 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 41431004503 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 41431004504 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 41431004505 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 41431004506 MgtE intracellular N domain; Region: MgtE_N; cl15244 41431004507 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 41431004508 Divalent cation transporter; Region: MgtE; cl00786 41431004509 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431004510 structural tetrad; other site 41431004511 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 41431004512 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 41431004513 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 41431004514 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 41431004515 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 41431004516 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 41431004517 thioester formation/cholesterol transfer; other site 41431004518 protein-splicing catalytic site; other site 41431004519 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 41431004520 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 41431004521 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 41431004522 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 41431004523 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 41431004524 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 41431004525 [2Fe-2S] cluster binding site [ion binding]; other site 41431004526 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 41431004527 hydrophobic ligand binding site; other site 41431004528 arginine decarboxylase; Provisional; Region: PRK05354 41431004529 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 41431004530 dimer interface [polypeptide binding]; other site 41431004531 active site 41431004532 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 41431004533 catalytic residues [active] 41431004534 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 41431004535 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 41431004536 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892 41431004537 CRISPR/Cas system-associated protein Cas8c'; Region: Cas8c'_I-D; cl11893 41431004538 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 41431004539 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 41431004540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431004541 Walker A motif; other site 41431004542 ATP binding site [chemical binding]; other site 41431004543 Walker B motif; other site 41431004544 arginine finger; other site 41431004545 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 41431004546 Integrase core domain; Region: rve; cl01316 41431004547 YcfA-like protein; Region: YcfA; cl00752 41431004548 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431004549 Predicted helicase [General function prediction only]; Region: COG4889 41431004550 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004551 putative active site [active] 41431004552 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 41431004553 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431004554 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 41431004555 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 41431004556 active site 41431004557 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 41431004558 Exoribonuclease R [Transcription]; Region: VacB; COG0557 41431004559 RNB domain; Region: RNB; pfam00773 41431004560 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 41431004561 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 41431004562 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 41431004563 FMN binding site [chemical binding]; other site 41431004564 active site 41431004565 substrate binding site [chemical binding]; other site 41431004566 catalytic residue [active] 41431004567 putative phosphoketolase; Provisional; Region: PRK05261 41431004568 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 41431004569 TPP-binding site; other site 41431004570 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 41431004571 XFP C-terminal domain; Region: XFP_C; pfam09363 41431004572 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 41431004573 catalytic triad [active] 41431004574 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 41431004575 active site 41431004576 oxyanion hole [active] 41431004577 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 41431004578 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 41431004579 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 41431004580 dihydrodipicolinate reductase; Provisional; Region: PRK00048 41431004581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431004582 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 41431004583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431004584 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 41431004585 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 41431004586 generic binding surface II; other site 41431004587 generic binding surface I; other site 41431004588 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 41431004589 putative active site [active] 41431004590 putative catalytic site [active] 41431004591 putative Mg binding site IVb [ion binding]; other site 41431004592 putative phosphate binding site [ion binding]; other site 41431004593 putative DNA binding site [nucleotide binding]; other site 41431004594 putative Mg binding site IVa [ion binding]; other site 41431004595 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431004596 Helix-turn-helix domains; Region: HTH; cl00088 41431004597 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 41431004598 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 41431004599 enolase; Provisional; Region: eno; PRK00077 41431004600 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 41431004601 dimer interface [polypeptide binding]; other site 41431004602 metal binding site [ion binding]; metal-binding site 41431004603 substrate binding pocket [chemical binding]; other site 41431004604 PUCC protein; Region: PUCC; pfam03209 41431004605 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 41431004606 phosphodiesterase; Provisional; Region: PRK12704 41431004607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 41431004608 dimerization interface [polypeptide binding]; other site 41431004609 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 41431004610 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 41431004611 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 41431004612 catalytic residue [active] 41431004613 Protein of unknown function (DUF552); Region: DUF552; cl00775 41431004614 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 41431004615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431004616 Cytochrome P450; Region: p450; cl12078 41431004617 Sugar fermentation stimulation protein; Region: SfsA; cl00647 41431004618 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431004619 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 41431004620 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 41431004621 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 41431004622 FMN binding site [chemical binding]; other site 41431004623 active site 41431004624 catalytic residues [active] 41431004625 substrate binding site [chemical binding]; other site 41431004626 hydrolase, alpha/beta fold family protein; Region: PLN02824 41431004627 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 41431004628 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 41431004629 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 41431004630 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 41431004631 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 41431004632 Ligand Binding Site [chemical binding]; other site 41431004633 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431004634 Ligand Binding Site [chemical binding]; other site 41431004635 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431004636 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431004637 GAF domain; Region: GAF; cl00853 41431004638 two component system sensor kinase SsrA; Provisional; Region: PRK15347 41431004639 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431004640 metal binding site [ion binding]; metal-binding site 41431004641 active site 41431004642 I-site; other site 41431004643 Response regulator receiver domain; Region: Response_reg; pfam00072 41431004644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004645 active site 41431004646 phosphorylation site [posttranslational modification] 41431004647 intermolecular recognition site; other site 41431004648 dimerization interface [polypeptide binding]; other site 41431004649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 41431004650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004651 ATP binding site [chemical binding]; other site 41431004652 Mg2+ binding site [ion binding]; other site 41431004653 G-X-G motif; other site 41431004654 GAF domain; Region: GAF; cl00853 41431004655 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431004656 GAF domain; Region: GAF; cl00853 41431004657 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431004658 GAF domain; Region: GAF; cl00853 41431004659 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431004660 GAF domain; Region: GAF; cl00853 41431004661 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431004662 GAF domain; Region: GAF; cl00853 41431004663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 41431004664 PAS fold; Region: PAS_4; pfam08448 41431004665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004666 phosphorylation site [posttranslational modification] 41431004667 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431004668 Ycf46; Provisional; Region: ycf46; CHL00195 41431004669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431004670 Walker A motif; other site 41431004671 ATP binding site [chemical binding]; other site 41431004672 Walker B motif; other site 41431004673 arginine finger; other site 41431004674 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431004675 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 41431004676 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 41431004677 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 41431004678 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004679 putative active site [active] 41431004680 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 41431004681 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 41431004682 Domain of unknown function DUF37; Region: DUF37; cl00506 41431004683 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 41431004684 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 41431004685 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 41431004686 C-terminal domain interface [polypeptide binding]; other site 41431004687 active site 41431004688 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 41431004689 active site 41431004690 N-terminal domain interface [polypeptide binding]; other site 41431004691 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 41431004692 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 41431004693 putative metal binding site; other site 41431004694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431004695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004696 binding surface 41431004697 TPR motif; other site 41431004698 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 41431004699 peripheral dimer interface [polypeptide binding]; other site 41431004700 core dimer interface [polypeptide binding]; other site 41431004701 L10 interface [polypeptide binding]; other site 41431004702 L11 interface [polypeptide binding]; other site 41431004703 putative EF-Tu interaction site [polypeptide binding]; other site 41431004704 putative EF-G interaction site [polypeptide binding]; other site 41431004705 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 41431004706 23S rRNA interface [nucleotide binding]; other site 41431004707 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 41431004708 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 41431004709 mRNA/rRNA interface [nucleotide binding]; other site 41431004710 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 41431004711 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 41431004712 23S rRNA interface [nucleotide binding]; other site 41431004713 L7/L12 interface [polypeptide binding]; other site 41431004714 putative thiostrepton binding site; other site 41431004715 L25 interface [polypeptide binding]; other site 41431004716 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 41431004717 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 41431004718 putative homodimer interface [polypeptide binding]; other site 41431004719 KOW motif; Region: KOW; cl00354 41431004720 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 41431004721 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 41431004722 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431004723 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 41431004724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004725 binding surface 41431004726 TPR motif; other site 41431004727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004728 binding surface 41431004729 TPR motif; other site 41431004730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004731 binding surface 41431004732 TPR motif; other site 41431004733 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 41431004734 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 41431004735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431004736 catalytic residue [active] 41431004737 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 41431004738 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 41431004739 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 41431004740 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 41431004741 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 41431004742 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 41431004743 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 41431004744 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 41431004745 DNA binding site [nucleotide binding] 41431004746 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 41431004747 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 41431004748 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 41431004749 RPB12 interaction site [polypeptide binding]; other site 41431004750 RPB1 interaction site [polypeptide binding]; other site 41431004751 RPB10 interaction site [polypeptide binding]; other site 41431004752 RPB11 interaction site [polypeptide binding]; other site 41431004753 RPB3 interaction site [polypeptide binding]; other site 41431004754 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 41431004755 active site 41431004756 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 41431004757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 41431004758 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 41431004759 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 41431004760 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431004761 Walker A/P-loop; other site 41431004762 ATP binding site [chemical binding]; other site 41431004763 Q-loop/lid; other site 41431004764 ABC transporter signature motif; other site 41431004765 Walker B; other site 41431004766 D-loop; other site 41431004767 H-loop/switch region; other site 41431004768 TOBE domain; Region: TOBE_2; cl01440 41431004769 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 41431004770 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 41431004771 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 41431004772 Walker A/P-loop; other site 41431004773 ATP binding site [chemical binding]; other site 41431004774 Q-loop/lid; other site 41431004775 ABC transporter signature motif; other site 41431004776 Walker B; other site 41431004777 D-loop; other site 41431004778 H-loop/switch region; other site 41431004779 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 41431004780 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 41431004781 Walker A/P-loop; other site 41431004782 ATP binding site [chemical binding]; other site 41431004783 Q-loop/lid; other site 41431004784 ABC transporter signature motif; other site 41431004785 Walker B; other site 41431004786 D-loop; other site 41431004787 H-loop/switch region; other site 41431004788 Cobalt transport protein; Region: CbiQ; cl00463 41431004789 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004790 putative active site [active] 41431004791 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 41431004792 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 41431004793 putative catalytic cysteine [active] 41431004794 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431004795 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 41431004796 Cupin domain; Region: Cupin_2; cl09118 41431004797 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 41431004798 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 41431004799 active site 41431004800 substrate binding site [chemical binding]; other site 41431004801 metal binding site [ion binding]; metal-binding site 41431004802 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 41431004803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431004804 FeS/SAM binding site; other site 41431004805 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 41431004806 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431004807 Uncharacterized conserved protein [Function unknown]; Region: COG4938 41431004808 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 41431004809 ArsC family; Region: ArsC; pfam03960 41431004810 putative catalytic residues [active] 41431004811 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 41431004812 dimer interface [polypeptide binding]; other site 41431004813 [2Fe-2S] cluster binding site [ion binding]; other site 41431004814 NifT/FixU protein; Region: NifT; cl02351 41431004815 NifZ domain; Region: NifZ; pfam04319 41431004816 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 41431004817 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 41431004818 active site 41431004819 catalytic residues [active] 41431004820 metal binding site [ion binding]; metal-binding site 41431004821 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 41431004822 serine O-acetyltransferase; Region: cysE; TIGR01172 41431004823 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 41431004824 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 41431004825 trimer interface [polypeptide binding]; other site 41431004826 active site 41431004827 substrate binding site [chemical binding]; other site 41431004828 CoA binding site [chemical binding]; other site 41431004829 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 41431004830 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431004831 FeS/SAM binding site; other site 41431004832 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 41431004833 ferredoxin; Validated; Region: PRK07118 41431004834 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431004835 Aminotransferase class-V; Region: Aminotran_5; pfam00266 41431004836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431004837 catalytic residue [active] 41431004838 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 41431004839 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 41431004840 trimerization site [polypeptide binding]; other site 41431004841 active site 41431004842 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 41431004843 NifU-like domain; Region: NifU; cl00484 41431004844 nitrogenase reductase; Reviewed; Region: PRK13236 41431004845 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 41431004846 Nucleotide-binding sites [chemical binding]; other site 41431004847 Walker A motif; other site 41431004848 Switch I region of nucleotide binding site; other site 41431004849 Fe4S4 binding sites [ion binding]; other site 41431004850 Switch II region of nucleotide binding site; other site 41431004851 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 41431004852 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 41431004853 MoFe protein alpha/beta subunit interactions; other site 41431004854 Alpha subunit P cluster binding residues; other site 41431004855 FeMoco binding residues [chemical binding]; other site 41431004856 MoFe protein alpha subunit/Fe protein contacts; other site 41431004857 MoFe protein dimer/ dimer interactions; other site 41431004858 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 41431004859 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 41431004860 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 41431004861 MoFe protein beta/alpha subunit interactions; other site 41431004862 Beta subunit P cluster binding residues; other site 41431004863 MoFe protein beta subunit/Fe protein contacts; other site 41431004864 MoFe protein dimer/ dimer interactions; other site 41431004865 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 41431004866 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 41431004867 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 41431004868 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 41431004869 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 41431004870 Protein of unknown function, DUF269; Region: DUF269; cl03973 41431004871 Protein of unknown function (DUF683); Region: DUF683; cl02247 41431004872 Nitrogen fixation protein NifW; Region: NifW; cl03935 41431004873 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 41431004874 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 41431004875 ATP binding site [chemical binding]; other site 41431004876 substrate interface [chemical binding]; other site 41431004877 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 41431004878 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431004879 catalytic loop [active] 41431004880 iron binding site [ion binding]; other site 41431004881 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 41431004882 G1 box; other site 41431004883 GTP/Mg2+ binding site [chemical binding]; other site 41431004884 Switch I region; other site 41431004885 G2 box; other site 41431004886 G3 box; other site 41431004887 Switch II region; other site 41431004888 G4 box; other site 41431004889 G5 box; other site 41431004890 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 41431004891 Nucleoside recognition; Region: Gate; cl00486 41431004892 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 41431004893 Nucleoside recognition; Region: Gate; cl00486 41431004894 FeoA domain; Region: FeoA; cl00838 41431004895 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 41431004896 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 41431004897 Acyl transferase domain; Region: Acyl_transf_1; cl08282 41431004898 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 41431004899 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 41431004900 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 41431004901 dimer interface [polypeptide binding]; other site 41431004902 active site 41431004903 CoA binding pocket [chemical binding]; other site 41431004904 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 41431004905 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 41431004906 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 41431004907 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 41431004908 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431004909 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431004910 active site 41431004911 ATP binding site [chemical binding]; other site 41431004912 substrate binding site [chemical binding]; other site 41431004913 activation loop (A-loop); other site 41431004914 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 41431004915 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431004916 Protein required for attachment to host cells; Region: Host_attach; cl02398 41431004917 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431004918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004919 active site 41431004920 phosphorylation site [posttranslational modification] 41431004921 intermolecular recognition site; other site 41431004922 dimerization interface [polypeptide binding]; other site 41431004923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431004924 DNA binding residues [nucleotide binding] 41431004925 dimerization interface [polypeptide binding]; other site 41431004926 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 41431004927 Protein of unknown function, DUF393; Region: DUF393; cl01136 41431004928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 41431004929 Helix-turn-helix domains; Region: HTH; cl00088 41431004930 Transposase; Region: DDE_Tnp_ISL3; pfam01610 41431004931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431004932 PemK-like protein; Region: PemK; cl00995 41431004933 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 41431004934 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 41431004935 dimer interface [polypeptide binding]; other site 41431004936 anticodon binding site; other site 41431004937 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 41431004938 homodimer interface [polypeptide binding]; other site 41431004939 motif 1; other site 41431004940 active site 41431004941 motif 2; other site 41431004942 GAD domain; Region: GAD; pfam02938 41431004943 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 41431004944 motif 3; other site 41431004945 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 41431004946 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 41431004947 active site 41431004948 catalytic triad [active] 41431004949 oxyanion hole [active] 41431004950 MAPEG family; Region: MAPEG; cl09190 41431004951 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 41431004952 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 41431004953 CHASE2 domain; Region: CHASE2; cl01732 41431004954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431004955 metal binding site [ion binding]; metal-binding site 41431004956 active site 41431004957 I-site; other site 41431004958 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431004959 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 41431004960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431004961 motif II; other site 41431004962 S-adenosylmethionine synthetase; Validated; Region: PRK05250 41431004963 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 41431004964 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 41431004965 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 41431004966 MbtH-like protein; Region: MbtH; cl01279 41431004967 peptide synthase; Provisional; Region: PRK12467 41431004968 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431004969 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431004970 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431004971 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431004972 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 41431004973 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431004974 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 41431004975 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431004976 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 41431004977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004978 binding surface 41431004979 TPR motif; other site 41431004980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004981 binding surface 41431004982 TPR motif; other site 41431004983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004984 binding surface 41431004985 TPR motif; other site 41431004986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004987 binding surface 41431004988 TPR motif; other site 41431004989 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 41431004990 tetramerization interface [polypeptide binding]; other site 41431004991 active site 41431004992 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431004993 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 41431004994 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431004995 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 41431004996 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 41431004997 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 41431004998 metal binding site 2 [ion binding]; metal-binding site 41431004999 putative DNA binding helix; other site 41431005000 metal binding site 1 [ion binding]; metal-binding site 41431005001 dimer interface [polypeptide binding]; other site 41431005002 structural Zn2+ binding site [ion binding]; other site 41431005003 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431005004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005005 active site 41431005006 dimerization interface [polypeptide binding]; other site 41431005007 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 41431005008 cell division protein; Validated; Region: ftsH; CHL00176 41431005009 FtsH Extracellular; Region: FtsH_ext; pfam06480 41431005010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431005011 Walker A motif; other site 41431005012 ATP binding site [chemical binding]; other site 41431005013 Walker B motif; other site 41431005014 arginine finger; other site 41431005015 Peptidase family M41; Region: Peptidase_M41; pfam01434 41431005016 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 41431005017 anti sigma factor interaction site; other site 41431005018 regulatory phosphorylation site [posttranslational modification]; other site 41431005019 Response regulator receiver domain; Region: Response_reg; pfam00072 41431005020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005021 active site 41431005022 phosphorylation site [posttranslational modification] 41431005023 intermolecular recognition site; other site 41431005024 dimerization interface [polypeptide binding]; other site 41431005025 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 41431005026 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 41431005027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 41431005028 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 41431005029 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 41431005030 active site residue [active] 41431005031 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 41431005032 active site residue [active] 41431005033 Uncharacterized conserved protein [Function unknown]; Region: COG1432 41431005034 LabA_like proteins; Region: LabA; cd10911 41431005035 putative metal binding site [ion binding]; other site 41431005036 Nitrogen regulatory protein P-II; Region: P-II; cl00412 41431005037 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 41431005038 active site 41431005039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005040 TPR motif; other site 41431005041 binding surface 41431005042 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431005043 active site 41431005044 NTP binding site [chemical binding]; other site 41431005045 metal binding triad [ion binding]; metal-binding site 41431005046 antibiotic binding site [chemical binding]; other site 41431005047 Protein of unknown function DUF86; Region: DUF86; cl01031 41431005048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005049 TPR motif; other site 41431005050 Erythromycin esterase; Region: Erythro_esteras; pfam05139 41431005051 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431005052 active site 41431005053 NTP binding site [chemical binding]; other site 41431005054 metal binding triad [ion binding]; metal-binding site 41431005055 antibiotic binding site [chemical binding]; other site 41431005056 Protein of unknown function DUF86; Region: DUF86; cl01031 41431005057 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005058 putative active site [active] 41431005059 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 41431005060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005061 domain; Region: Succ_DH_flav_C; pfam02910 41431005062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431005063 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431005064 Probable transposase; Region: OrfB_IS605; pfam01385 41431005065 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431005066 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005067 putative active site [active] 41431005068 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431005069 Hexamer interface [polypeptide binding]; other site 41431005070 Hexagonal pore residue; other site 41431005071 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431005072 Hexamer interface [polypeptide binding]; other site 41431005073 Hexagonal pore residue; other site 41431005074 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431005075 extended (e) SDRs; Region: SDR_e; cd08946 41431005076 NAD(P) binding site [chemical binding]; other site 41431005077 active site 41431005078 substrate binding site [chemical binding]; other site 41431005079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005080 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 41431005081 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 41431005082 Walker A/P-loop; other site 41431005083 ATP binding site [chemical binding]; other site 41431005084 Q-loop/lid; other site 41431005085 ABC transporter signature motif; other site 41431005086 Walker B; other site 41431005087 D-loop; other site 41431005088 H-loop/switch region; other site 41431005089 ABC-2 type transporter; Region: ABC2_membrane; cl11417 41431005090 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 41431005091 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 41431005092 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 41431005093 P loop; other site 41431005094 Nucleotide binding site [chemical binding]; other site 41431005095 UbiA prenyltransferase family; Region: UbiA; cl00337 41431005096 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005097 putative active site [active] 41431005098 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 41431005099 quinone interaction residues [chemical binding]; other site 41431005100 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 41431005101 active site 41431005102 catalytic residues [active] 41431005103 FMN binding site [chemical binding]; other site 41431005104 substrate binding site [chemical binding]; other site 41431005105 homoserine kinase; Provisional; Region: PRK01212 41431005106 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 41431005107 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 41431005108 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 41431005109 putative active site [active] 41431005110 PemK-like protein; Region: PemK; cl00995 41431005111 Domain of unknown function (DUF3825); Region: DUF3825; pfam12873 41431005112 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 41431005113 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 41431005114 substrate binding site [chemical binding]; other site 41431005115 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 41431005116 substrate binding site [chemical binding]; other site 41431005117 ligand binding site [chemical binding]; other site 41431005118 XisI protein; Region: XisI; pfam08869 41431005119 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431005120 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 41431005121 XisI protein; Region: XisI; pfam08869 41431005122 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 41431005123 Membrane transport protein; Region: Mem_trans; cl09117 41431005124 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005125 putative active site [active] 41431005126 Cytochrome P450; Region: p450; cl12078 41431005127 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 41431005128 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 41431005129 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 41431005130 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431005131 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 41431005132 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 41431005133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431005134 dimer interface [polypeptide binding]; other site 41431005135 conserved gate region; other site 41431005136 putative PBP binding loops; other site 41431005137 ABC-ATPase subunit interface; other site 41431005138 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 41431005139 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 41431005140 dimerization interface [polypeptide binding]; other site 41431005141 putative active cleft [active] 41431005142 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 41431005143 conserved cys residue [active] 41431005144 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 41431005145 potential catalytic triad [active] 41431005146 conserved cys residue [active] 41431005147 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 41431005148 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 41431005149 PYR/PP interface [polypeptide binding]; other site 41431005150 dimer interface [polypeptide binding]; other site 41431005151 TPP binding site [chemical binding]; other site 41431005152 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 41431005153 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 41431005154 TPP-binding site [chemical binding]; other site 41431005155 dimer interface [polypeptide binding]; other site 41431005156 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 41431005157 amphipathic channel; other site 41431005158 Asn-Pro-Ala signature motifs; other site 41431005159 Protein of unknown function (DUF751); Region: DUF751; pfam05421 41431005160 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 41431005161 Uncharacterized conserved protein [Function unknown]; Region: COG2308 41431005162 Domain of unknown function (DUF404); Region: DUF404; pfam04169 41431005163 Domain of unknown function (DUF407); Region: DUF407; pfam04174 41431005164 Predicted dehydrogenase [General function prediction only]; Region: COG0579 41431005165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005166 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005167 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005168 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005169 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 41431005170 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 41431005171 NAD(P) binding site [chemical binding]; other site 41431005172 putative active site [active] 41431005173 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 41431005174 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431005175 phosphopeptide binding site; other site 41431005176 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 41431005177 Transglycosylase; Region: Transgly; cl07896 41431005178 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 41431005179 FtsH Extracellular; Region: FtsH_ext; pfam06480 41431005180 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 41431005181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431005182 Walker A motif; other site 41431005183 ATP binding site [chemical binding]; other site 41431005184 Walker B motif; other site 41431005185 arginine finger; other site 41431005186 Peptidase family M41; Region: Peptidase_M41; pfam01434 41431005187 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 41431005188 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431005189 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 41431005190 homotrimer interaction site [polypeptide binding]; other site 41431005191 putative active site [active] 41431005192 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 41431005193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431005194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005195 active site 41431005196 phosphorylation site [posttranslational modification] 41431005197 intermolecular recognition site; other site 41431005198 dimerization interface [polypeptide binding]; other site 41431005199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431005200 DNA binding residues [nucleotide binding] 41431005201 dimerization interface [polypeptide binding]; other site 41431005202 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431005203 dimer interface [polypeptide binding]; other site 41431005204 phosphorylation site [posttranslational modification] 41431005205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431005206 ATP binding site [chemical binding]; other site 41431005207 Mg2+ binding site [ion binding]; other site 41431005208 G-X-G motif; other site 41431005209 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 41431005210 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 41431005211 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431005212 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 41431005213 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431005214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431005215 Probable transposase; Region: OrfB_IS605; pfam01385 41431005216 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431005217 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 41431005218 K+-transporting ATPase, c chain; Region: KdpC; cl00944 41431005219 Electron transfer DM13; Region: DM13; cl02735 41431005220 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 41431005221 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431005222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005223 active site 41431005224 phosphorylation site [posttranslational modification] 41431005225 intermolecular recognition site; other site 41431005226 dimerization interface [polypeptide binding]; other site 41431005227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431005228 DNA binding site [nucleotide binding] 41431005229 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 41431005230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 41431005231 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 41431005232 ATP binding site [chemical binding]; other site 41431005233 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 41431005234 Protein of unknown function (DUF565); Region: DUF565; pfam04483 41431005235 D-glycerate 3-kinase; Provisional; Region: PLN03046 41431005236 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431005237 active site 41431005238 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 41431005239 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 41431005240 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 41431005241 active site 41431005242 homodimer interface [polypeptide binding]; other site 41431005243 catalytic site [active] 41431005244 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005245 putative active site [active] 41431005246 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 41431005247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005248 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 41431005249 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 41431005250 Sporulation related domain; Region: SPOR; cl10051 41431005251 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 41431005252 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005253 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005254 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005255 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005256 Predicted domain in sensory proteins (DUF2308); Region: DUF2308; cl01731 41431005257 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 41431005258 cytosine deaminase-like protein; Validated; Region: PRK07583 41431005259 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 41431005260 active site 41431005261 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 41431005262 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 41431005263 Cysteine-rich domain; Region: CCG; pfam02754 41431005264 Cysteine-rich domain; Region: CCG; pfam02754 41431005265 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 41431005266 FAD binding domain; Region: FAD_binding_4; pfam01565 41431005267 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 41431005268 hypothetical protein; Provisional; Region: PRK00468; cl00794 41431005269 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 41431005270 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 41431005271 putative active site [active] 41431005272 hypothetical protein; Provisional; Region: PRK13683 41431005273 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 41431005274 D1 interface; other site 41431005275 chlorophyll binding site; other site 41431005276 pheophytin binding site; other site 41431005277 beta carotene binding site; other site 41431005278 cytochrome b559 beta interface; other site 41431005279 quinone binding site; other site 41431005280 cytochrome b559 alpha interface; other site 41431005281 protein J interface; other site 41431005282 protein H interface; other site 41431005283 protein X interface; other site 41431005284 core light harvesting protein interface; other site 41431005285 protein L interface; other site 41431005286 CP43 interface; other site 41431005287 protein T interface; other site 41431005288 Fe binding site [ion binding]; other site 41431005289 protein M interface; other site 41431005290 Mn-stabilizing polypeptide interface; other site 41431005291 bromide binding site; other site 41431005292 cytochrome c-550 interface; other site 41431005293 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 41431005294 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 41431005295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005297 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 41431005298 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 41431005299 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 41431005300 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431005301 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 41431005302 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 41431005303 FtsX-like permease family; Region: FtsX; pfam02687 41431005304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 41431005305 Protein of unknown function (DUF497); Region: DUF497; cl01108 41431005306 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 41431005307 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 41431005308 active site 41431005309 NTP binding site [chemical binding]; other site 41431005310 metal binding triad [ion binding]; metal-binding site 41431005311 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 41431005312 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 41431005313 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 41431005314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431005315 Walker A motif; other site 41431005316 ATP binding site [chemical binding]; other site 41431005317 Walker B motif; other site 41431005318 arginine finger; other site 41431005319 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 41431005320 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 41431005321 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 41431005322 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 41431005323 active site 41431005324 zinc binding site [ion binding]; other site 41431005325 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431005326 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 41431005327 Phage Tail Collar Domain; Region: Collar; pfam07484 41431005328 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl12039 41431005329 active site 41431005330 dimer interface [polypeptide binding]; other site 41431005331 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 41431005332 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 41431005333 acetylornithine aminotransferase; Provisional; Region: PRK02627 41431005334 inhibitor-cofactor binding pocket; inhibition site 41431005335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431005336 catalytic residue [active] 41431005337 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 41431005338 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431005339 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 41431005340 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 41431005341 EamA-like transporter family; Region: EamA; cl01037 41431005342 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 41431005343 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 41431005344 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 41431005345 Walker A/P-loop; other site 41431005346 ATP binding site [chemical binding]; other site 41431005347 Q-loop/lid; other site 41431005348 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 41431005349 ABC transporter signature motif; other site 41431005350 Walker B; other site 41431005351 D-loop; other site 41431005352 H-loop/switch region; other site 41431005353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 41431005354 Integrase core domain; Region: rve; cl01316 41431005355 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 41431005356 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 41431005357 G1 box; other site 41431005358 putative GEF interaction site [polypeptide binding]; other site 41431005359 GTP/Mg2+ binding site [chemical binding]; other site 41431005360 Switch I region; other site 41431005361 G2 box; other site 41431005362 G3 box; other site 41431005363 Switch II region; other site 41431005364 G4 box; other site 41431005365 G5 box; other site 41431005366 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 41431005367 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 41431005368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431005369 motif II; other site 41431005370 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431005371 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 41431005372 putative NAD(P) binding site [chemical binding]; other site 41431005373 active site 41431005374 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 41431005375 Ligand Binding Site [chemical binding]; other site 41431005376 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 41431005377 PLU-1-like protein; Region: PLU-1; pfam08429 41431005378 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 41431005379 nudix motif; other site 41431005380 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 41431005381 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 41431005382 domain interfaces; other site 41431005383 active site 41431005384 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 41431005385 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 41431005386 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431005387 MarC family integral membrane protein; Region: MarC; cl00919 41431005388 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 41431005389 Cytochrome c; Region: Cytochrom_C; cl11414 41431005390 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 41431005391 Stage II sporulation protein; Region: SpoIID; pfam08486 41431005392 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 41431005393 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 41431005394 protein I interface; other site 41431005395 D2 interface; other site 41431005396 protein T interface; other site 41431005397 chlorophyll binding site; other site 41431005398 beta carotene binding site; other site 41431005399 pheophytin binding site; other site 41431005400 manganese-stabilizing polypeptide interface; other site 41431005401 CP43 interface; other site 41431005402 protein L interface; other site 41431005403 oxygen evolving complex binding site; other site 41431005404 bromide binding site; other site 41431005405 quinone binding site; other site 41431005406 Fe binding site [ion binding]; other site 41431005407 core light harvesting interface; other site 41431005408 cytochrome b559 alpha subunit interface; other site 41431005409 cytochrome c-550 interface; other site 41431005410 protein J interface; other site 41431005411 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005412 putative active site [active] 41431005413 spermine synthase; Region: PLN02823 41431005414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431005415 S-adenosylmethionine binding site [chemical binding]; other site 41431005416 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 41431005417 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 41431005418 putative catalytic cysteine [active] 41431005419 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005420 putative active site [active] 41431005421 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 41431005422 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 41431005423 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 41431005424 Membrane protein of unknown function; Region: DUF360; cl00850 41431005425 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 41431005426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431005427 ATP binding site [chemical binding]; other site 41431005428 putative Mg++ binding site [ion binding]; other site 41431005429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431005430 nucleotide binding region [chemical binding]; other site 41431005431 ATP-binding site [chemical binding]; other site 41431005432 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005433 putative active site [active] 41431005434 Domain of unknown function DUF28; Region: DUF28; cl00361 41431005435 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 41431005436 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 41431005437 putative NADP binding site [chemical binding]; other site 41431005438 putative substrate binding site [chemical binding]; other site 41431005439 active site 41431005440 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431005441 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 41431005442 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431005443 Walker A/P-loop; other site 41431005444 ATP binding site [chemical binding]; other site 41431005445 Q-loop/lid; other site 41431005446 ABC transporter signature motif; other site 41431005447 Walker B; other site 41431005448 D-loop; other site 41431005449 H-loop/switch region; other site 41431005450 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 41431005451 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 41431005452 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 41431005453 putative active site [active] 41431005454 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 41431005455 active site 41431005456 putative substrate binding region [chemical binding]; other site 41431005457 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 41431005458 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 41431005459 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 41431005460 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 41431005461 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431005462 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 41431005463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431005464 S-adenosylmethionine binding site [chemical binding]; other site 41431005465 Response regulator receiver domain; Region: Response_reg; pfam00072 41431005466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005467 active site 41431005468 phosphorylation site [posttranslational modification] 41431005469 intermolecular recognition site; other site 41431005470 dimerization interface [polypeptide binding]; other site 41431005471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431005472 metal binding site [ion binding]; metal-binding site 41431005473 active site 41431005474 I-site; other site 41431005475 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 41431005476 dimer interface [polypeptide binding]; other site 41431005477 substrate binding site [chemical binding]; other site 41431005478 metal binding sites [ion binding]; metal-binding site 41431005479 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 41431005480 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 41431005481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431005482 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431005483 Probable transposase; Region: OrfB_IS605; pfam01385 41431005484 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431005485 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431005486 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 41431005487 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 41431005488 trimer interface [polypeptide binding]; other site 41431005489 active site 41431005490 substrate binding site [chemical binding]; other site 41431005491 CoA binding site [chemical binding]; other site 41431005492 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 41431005493 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 41431005494 FAD binding site [chemical binding]; other site 41431005495 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 41431005496 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 41431005497 active site 41431005498 HIGH motif; other site 41431005499 dimer interface [polypeptide binding]; other site 41431005500 KMSKS motif; other site 41431005501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005502 active site 41431005503 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 41431005504 phosphorylation site [posttranslational modification] 41431005505 intermolecular recognition site; other site 41431005506 dimerization interface [polypeptide binding]; other site 41431005507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431005508 putative active site [active] 41431005509 heme pocket [chemical binding]; other site 41431005510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431005511 metal binding site [ion binding]; metal-binding site 41431005512 active site 41431005513 I-site; other site 41431005514 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 41431005515 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 41431005516 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 41431005517 Moco binding site; other site 41431005518 metal coordination site [ion binding]; other site 41431005519 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 41431005520 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 41431005521 NAD binding site [chemical binding]; other site 41431005522 homotetramer interface [polypeptide binding]; other site 41431005523 homodimer interface [polypeptide binding]; other site 41431005524 substrate binding site [chemical binding]; other site 41431005525 active site 41431005526 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431005527 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 41431005528 ligand binding site [chemical binding]; other site 41431005529 flexible hinge region; other site 41431005530 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 41431005531 putative switch regulator; other site 41431005532 non-specific DNA interactions [nucleotide binding]; other site 41431005533 DNA binding site [nucleotide binding] 41431005534 sequence specific DNA binding site [nucleotide binding]; other site 41431005535 putative cAMP binding site [chemical binding]; other site 41431005536 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 41431005537 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 41431005538 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 41431005539 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 41431005540 Ligand binding site; other site 41431005541 Putative Catalytic site; other site 41431005542 DXD motif; other site 41431005543 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 41431005544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431005545 substrate binding pocket [chemical binding]; other site 41431005546 membrane-bound complex binding site; other site 41431005547 hinge residues; other site 41431005548 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 41431005549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 41431005550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431005551 putative PBP binding loops; other site 41431005552 dimer interface [polypeptide binding]; other site 41431005553 ABC-ATPase subunit interface; other site 41431005554 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 41431005555 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 41431005556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431005557 FeS/SAM binding site; other site 41431005558 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 41431005559 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005560 putative active site [active] 41431005561 Domain of unknown function (DUF427); Region: DUF427; cl00998 41431005562 Uncharacterized conserved protein [Function unknown]; Region: COG4278 41431005563 phycobillisome linker protein; Region: apcE; CHL00091 41431005564 Phycobilisome protein; Region: Phycobilisome; cl08227 41431005565 Phycobilisome protein; Region: Phycobilisome; cl08227 41431005566 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431005567 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431005568 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431005569 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 41431005570 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 41431005571 dimer interface [polypeptide binding]; other site 41431005572 catalytic residue [active] 41431005573 metal binding site [ion binding]; metal-binding site 41431005574 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 41431005575 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 41431005576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431005577 Walker A motif; other site 41431005578 ATP binding site [chemical binding]; other site 41431005579 Walker B motif; other site 41431005580 arginine finger; other site 41431005581 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 41431005582 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 41431005583 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 41431005584 putative metal binding site [ion binding]; other site 41431005585 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 41431005586 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 41431005587 putative metal binding site [ion binding]; other site 41431005588 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 41431005589 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 41431005590 putative metal binding site [ion binding]; other site 41431005591 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 41431005592 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 41431005593 active site 41431005594 Riboflavin kinase; Region: Flavokinase; cl03312 41431005595 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431005596 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431005597 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431005598 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431005599 active site 41431005600 ATP binding site [chemical binding]; other site 41431005601 substrate binding site [chemical binding]; other site 41431005602 activation loop (A-loop); other site 41431005603 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 41431005604 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 41431005605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431005606 S-adenosylmethionine binding site [chemical binding]; other site 41431005607 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl00132 41431005608 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 41431005609 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 41431005610 active site 41431005611 metal binding site [ion binding]; metal-binding site 41431005612 DNA binding site [nucleotide binding] 41431005613 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 41431005614 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 41431005615 CHASE domain; Region: CHASE; cl01369 41431005616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431005617 dimer interface [polypeptide binding]; other site 41431005618 phosphorylation site [posttranslational modification] 41431005619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431005620 ATP binding site [chemical binding]; other site 41431005621 Mg2+ binding site [ion binding]; other site 41431005622 G-X-G motif; other site 41431005623 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431005624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005625 active site 41431005626 phosphorylation site [posttranslational modification] 41431005627 intermolecular recognition site; other site 41431005628 dimerization interface [polypeptide binding]; other site 41431005629 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431005630 GAF domain; Region: GAF; cl00853 41431005631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431005632 dimer interface [polypeptide binding]; other site 41431005633 phosphorylation site [posttranslational modification] 41431005634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431005635 ATP binding site [chemical binding]; other site 41431005636 Mg2+ binding site [ion binding]; other site 41431005637 G-X-G motif; other site 41431005638 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 41431005639 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 41431005640 dimer interface [polypeptide binding]; other site 41431005641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431005642 catalytic residue [active] 41431005643 HupE / UreJ protein; Region: HupE_UreJ; cl01011 41431005644 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 41431005645 Sporulation and spore germination; Region: Germane; cl11253 41431005646 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 41431005647 active site 41431005648 trimer interface [polypeptide binding]; other site 41431005649 allosteric site; other site 41431005650 active site lid [active] 41431005651 hexamer (dimer of trimers) interface [polypeptide binding]; other site 41431005652 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 41431005653 GSH binding site [chemical binding]; other site 41431005654 catalytic residues [active] 41431005655 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 41431005656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431005657 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 41431005658 Cytochrome c; Region: Cytochrom_C; cl11414 41431005659 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 41431005660 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 41431005661 NADP-binding site; other site 41431005662 homotetramer interface [polypeptide binding]; other site 41431005663 substrate binding site [chemical binding]; other site 41431005664 homodimer interface [polypeptide binding]; other site 41431005665 active site 41431005666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 41431005667 active site 41431005668 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431005669 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 41431005670 active site 41431005671 catalytic site [active] 41431005672 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 41431005673 Oxygen evolving enhancer protein 3 (PsbQ); Region: PsbQ; cl05363 41431005674 alpha/beta hydrolase fold protein; Provisional; Region: PLN03084 41431005675 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431005676 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 41431005677 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431005678 primosome assembly protein PriA; Validated; Region: PRK05580 41431005679 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 41431005680 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 41431005681 active site 41431005682 dimer interface [polypeptide binding]; other site 41431005683 catalytic residue [active] 41431005684 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 41431005685 Ca2+ binding site [ion binding]; other site 41431005686 Membrane protein of unknown function; Region: DUF360; cl00850 41431005687 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 41431005688 OstA-like protein; Region: OstA; cl00844 41431005689 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 41431005690 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 41431005691 Walker A/P-loop; other site 41431005692 ATP binding site [chemical binding]; other site 41431005693 Q-loop/lid; other site 41431005694 ABC transporter signature motif; other site 41431005695 Walker B; other site 41431005696 D-loop; other site 41431005697 H-loop/switch region; other site 41431005698 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 41431005699 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 41431005700 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 41431005701 catalytic triad [active] 41431005702 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 41431005703 Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527 41431005704 Protein-arginine deiminase (PAD); Region: PAD; pfam03068 41431005705 Survival protein SurE; Region: SurE; cl00448 41431005706 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 41431005707 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 41431005708 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 41431005709 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 41431005710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005711 NAD(P) binding site [chemical binding]; other site 41431005712 active site 41431005713 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 41431005714 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431005715 C-terminal domain interface [polypeptide binding]; other site 41431005716 GSH binding site (G-site) [chemical binding]; other site 41431005717 dimer interface [polypeptide binding]; other site 41431005718 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 41431005719 N-terminal domain interface [polypeptide binding]; other site 41431005720 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431005721 structural tetrad; other site 41431005722 malonyl-CoA synthase; Validated; Region: PRK07514 41431005723 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431005724 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 41431005725 starch-binding site 2 [chemical binding]; other site 41431005726 starch-binding site 1 [chemical binding]; other site 41431005727 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 41431005728 active site 41431005729 catalytic triad [active] 41431005730 oxyanion hole [active] 41431005731 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 41431005732 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 41431005733 trimerization site [polypeptide binding]; other site 41431005734 active site 41431005735 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 41431005736 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 41431005737 Ligand binding site; other site 41431005738 metal-binding site 41431005739 HEPN domain; Region: HEPN; cl00824 41431005740 Cytochrome P450; Region: p450; cl12078 41431005741 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 41431005742 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 41431005743 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431005744 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 41431005745 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 41431005746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431005747 FeS/SAM binding site; other site 41431005748 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431005749 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 41431005750 active site 41431005751 metal binding site [ion binding]; metal-binding site 41431005752 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 41431005753 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 41431005754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005755 binding surface 41431005756 TPR motif; other site 41431005757 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 41431005758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431005759 S-adenosylmethionine binding site [chemical binding]; other site 41431005760 sulfotransferase; Region: PLN02164 41431005761 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 41431005762 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 41431005763 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 41431005764 dimer interface [polypeptide binding]; other site 41431005765 PYR/PP interface [polypeptide binding]; other site 41431005766 TPP binding site [chemical binding]; other site 41431005767 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 41431005768 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 41431005769 TPP-binding site [chemical binding]; other site 41431005770 dimer interface [polypeptide binding]; other site 41431005771 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431005772 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005773 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005774 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005775 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005776 GAF domain; Region: GAF; cl00853 41431005777 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431005778 metal binding site [ion binding]; metal-binding site 41431005779 active site 41431005780 I-site; other site 41431005781 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 41431005782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005783 NAD(P) binding pocket [chemical binding]; other site 41431005784 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 41431005785 MASE1; Region: MASE1; pfam05231 41431005786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 41431005787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431005788 dimer interface [polypeptide binding]; other site 41431005789 phosphorylation site [posttranslational modification] 41431005790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431005791 ATP binding site [chemical binding]; other site 41431005792 Mg2+ binding site [ion binding]; other site 41431005793 G-X-G motif; other site 41431005794 Response regulator receiver domain; Region: Response_reg; pfam00072 41431005795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005796 active site 41431005797 phosphorylation site [posttranslational modification] 41431005798 intermolecular recognition site; other site 41431005799 dimerization interface [polypeptide binding]; other site 41431005800 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431005801 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 41431005802 active site 41431005803 dimer interface [polypeptide binding]; other site 41431005804 TOBE domain; Region: TOBE_2; cl01440 41431005805 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 41431005806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431005807 dimer interface [polypeptide binding]; other site 41431005808 conserved gate region; other site 41431005809 putative PBP binding loops; other site 41431005810 ABC-ATPase subunit interface; other site 41431005811 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 41431005812 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431005813 Walker A/P-loop; other site 41431005814 ATP binding site [chemical binding]; other site 41431005815 Q-loop/lid; other site 41431005816 ABC transporter signature motif; other site 41431005817 Walker B; other site 41431005818 D-loop; other site 41431005819 H-loop/switch region; other site 41431005820 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 41431005821 SmpB-tmRNA interface; other site 41431005822 conserved hypothetical protein; Region: TIGR02466 41431005823 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 41431005824 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431005825 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 41431005826 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 41431005827 Protein of unknown function, DUF393; Region: DUF393; cl01136 41431005828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431005829 Coenzyme A binding pocket [chemical binding]; other site 41431005830 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 41431005831 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 41431005832 Protein HOTHEAD; Region: PLN02785 41431005833 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 41431005834 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 41431005835 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 41431005836 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 41431005837 Walker A/P-loop; other site 41431005838 ATP binding site [chemical binding]; other site 41431005839 Q-loop/lid; other site 41431005840 ABC transporter signature motif; other site 41431005841 Walker B; other site 41431005842 D-loop; other site 41431005843 H-loop/switch region; other site 41431005844 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431005845 Ligand Binding Site [chemical binding]; other site 41431005846 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431005847 Ligand Binding Site [chemical binding]; other site 41431005848 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 41431005849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431005850 Probable transposase; Region: OrfB_IS605; pfam01385 41431005851 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431005852 SOS regulatory protein LexA; Region: lexA; TIGR00498 41431005853 Helix-turn-helix domains; Region: HTH; cl00088 41431005854 Helix-turn-helix domains; Region: HTH; cl00088 41431005855 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 41431005856 Catalytic site [active] 41431005857 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 41431005858 active site 41431005859 dinuclear metal binding site [ion binding]; other site 41431005860 dimerization interface [polypeptide binding]; other site 41431005861 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 41431005862 active site 41431005863 multimer interface [polypeptide binding]; other site 41431005864 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431005865 active site 41431005866 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431005867 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 41431005868 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 41431005869 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 41431005870 Ligand binding site; other site 41431005871 metal-binding site 41431005872 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 41431005873 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 41431005874 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 41431005875 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 41431005876 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005877 putative active site [active] 41431005878 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 41431005879 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 41431005880 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 41431005881 dihydroorotase; Validated; Region: pyrC; PRK09357 41431005882 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 41431005883 active site 41431005884 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 41431005885 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 41431005886 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 41431005887 putative peptidoglycan binding site; other site 41431005888 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 41431005889 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 41431005890 putative peptidoglycan binding site; other site 41431005891 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431005892 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431005893 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 41431005894 DNA binding residues [nucleotide binding] 41431005895 putative dimer interface [polypeptide binding]; other site 41431005896 HsdM N-terminal domain; Region: HsdM_N; pfam12161 41431005897 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 41431005898 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 41431005899 putative active site [active] 41431005900 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431005901 YcfA-like protein; Region: YcfA; cl00752 41431005902 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431005903 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431005904 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 41431005905 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 41431005906 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 41431005907 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431005908 Protein of unknown function DUF45; Region: DUF45; cl00636 41431005909 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 41431005910 DNA binding residues [nucleotide binding] 41431005911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431005912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431005913 dimer interface [polypeptide binding]; other site 41431005914 conserved gate region; other site 41431005915 putative PBP binding loops; other site 41431005916 ABC-ATPase subunit interface; other site 41431005917 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 41431005918 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005919 putative active site [active] 41431005920 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 41431005921 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431005922 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431005923 active site 41431005924 ATP binding site [chemical binding]; other site 41431005925 substrate binding site [chemical binding]; other site 41431005926 activation loop (A-loop); other site 41431005927 aspartate aminotransferase; Provisional; Region: PRK05942 41431005928 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431005929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431005930 homodimer interface [polypeptide binding]; other site 41431005931 catalytic residue [active] 41431005932 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431005933 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 41431005934 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 41431005935 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 41431005936 Protein of unknown function (DUF512); Region: DUF512; pfam04459 41431005937 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 41431005938 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 41431005939 Walker A/P-loop; other site 41431005940 ATP binding site [chemical binding]; other site 41431005941 Q-loop/lid; other site 41431005942 ABC transporter signature motif; other site 41431005943 Walker B; other site 41431005944 D-loop; other site 41431005945 H-loop/switch region; other site 41431005946 Adenosine specific kinase; Region: Adenosine_kin; cl00796 41431005947 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 41431005948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431005949 non-specific DNA binding site [nucleotide binding]; other site 41431005950 salt bridge; other site 41431005951 sequence-specific DNA binding site [nucleotide binding]; other site 41431005952 high affinity sulphate transporter 1; Region: sulP; TIGR00815 41431005953 Permease family; Region: Xan_ur_permease; cl00967 41431005954 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 41431005955 pyruvate kinase; Region: pyruv_kin; TIGR01064 41431005956 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 41431005957 domain interfaces; other site 41431005958 active site 41431005959 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 41431005960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005961 hydrolase, alpha/beta fold family protein; Region: PLN02679 41431005962 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431005963 HupF/HypC family; Region: HupF_HypC; cl00394 41431005964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005965 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 41431005966 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 41431005967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431005968 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 41431005969 diiron binding motif [ion binding]; other site 41431005970 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 41431005971 active site 41431005972 Preprotein translocase SecG subunit; Region: SecG; cl09123 41431005973 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 41431005974 Sulfatase; Region: Sulfatase; cl10460 41431005975 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 41431005976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431005977 dimer interface [polypeptide binding]; other site 41431005978 conserved gate region; other site 41431005979 putative PBP binding loops; other site 41431005980 ABC-ATPase subunit interface; other site 41431005981 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005982 putative active site [active] 41431005983 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 41431005984 conserved cys residue [active] 41431005985 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 41431005986 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 41431005987 peptide binding site [polypeptide binding]; other site 41431005988 dimer interface [polypeptide binding]; other site 41431005989 GUN4-like; Region: GUN4; pfam05419 41431005990 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 41431005991 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 41431005992 glutamine binding [chemical binding]; other site 41431005993 catalytic triad [active] 41431005994 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 41431005995 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 41431005996 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 41431005997 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 41431005998 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 41431005999 active site 41431006000 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 41431006001 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 41431006002 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 41431006003 Walker A/P-loop; other site 41431006004 ATP binding site [chemical binding]; other site 41431006005 Q-loop/lid; other site 41431006006 ABC transporter signature motif; other site 41431006007 Walker B; other site 41431006008 D-loop; other site 41431006009 H-loop/switch region; other site 41431006010 TOBE domain; Region: TOBE_2; cl01440 41431006011 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 41431006012 active site 41431006013 catalytic triad [active] 41431006014 oxyanion hole [active] 41431006015 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 41431006016 NeuB family; Region: NeuB; cl00496 41431006017 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 41431006018 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 41431006019 16S/18S rRNA binding site [nucleotide binding]; other site 41431006020 S13e-L30e interaction site [polypeptide binding]; other site 41431006021 25S rRNA binding site [nucleotide binding]; other site 41431006022 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431006023 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431006024 active site 41431006025 ATP binding site [chemical binding]; other site 41431006026 substrate binding site [chemical binding]; other site 41431006027 activation loop (A-loop); other site 41431006028 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 41431006029 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 41431006030 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 41431006031 putative active site [active] 41431006032 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 41431006033 putative active site [active] 41431006034 NIL domain; Region: NIL; cl09633 41431006035 4Fe-4S binding domain; Region: Fer4; cl02805 41431006036 hypothetical protein; Provisional; Region: PRK13795 41431006037 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 41431006038 catalytic residues [active] 41431006039 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 41431006040 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 41431006041 active site 41431006042 dimer interface [polypeptide binding]; other site 41431006043 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431006044 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 41431006045 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 41431006046 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 41431006047 Protein of unknown function DUF262; Region: DUF262; cl14890 41431006048 Ycf27; Reviewed; Region: orf27; CHL00148 41431006049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006050 active site 41431006051 phosphorylation site [posttranslational modification] 41431006052 intermolecular recognition site; other site 41431006053 dimerization interface [polypeptide binding]; other site 41431006054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431006055 DNA binding site [nucleotide binding] 41431006056 DNA repair protein RadA; Provisional; Region: PRK11823 41431006057 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 41431006058 Walker A motif/ATP binding site; other site 41431006059 ATP binding site [chemical binding]; other site 41431006060 Walker B motif; other site 41431006061 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 41431006062 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006063 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006064 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006065 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006066 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431006067 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 41431006068 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 41431006069 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 41431006070 HIGH motif; other site 41431006071 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 41431006072 active site 41431006073 KMSKS motif; other site 41431006074 ABC-2 type transporter; Region: ABC2_membrane; cl11417 41431006075 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 41431006076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006077 Walker A/P-loop; other site 41431006078 ATP binding site [chemical binding]; other site 41431006079 Q-loop/lid; other site 41431006080 ABC transporter signature motif; other site 41431006081 Walker B; other site 41431006082 D-loop; other site 41431006083 H-loop/switch region; other site 41431006084 ABC transporter; Region: ABC_tran_2; pfam12848 41431006085 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 41431006086 ABC transporter; Region: ABC_tran_2; pfam12848 41431006087 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431006088 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431006089 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431006090 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431006091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431006092 active site 41431006093 motif I; other site 41431006094 motif II; other site 41431006095 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 41431006096 dimer interface [polypeptide binding]; other site 41431006097 active site 41431006098 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431006099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431006100 NAD(P) binding site [chemical binding]; other site 41431006101 active site 41431006102 Membrane transport protein; Region: Mem_trans; cl09117 41431006103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 41431006104 dimerization interface [polypeptide binding]; other site 41431006105 putative DNA binding site [nucleotide binding]; other site 41431006106 putative Zn2+ binding site [ion binding]; other site 41431006107 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 41431006108 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 41431006109 putative NAD(P) binding site [chemical binding]; other site 41431006110 catalytic Zn binding site [ion binding]; other site 41431006111 structural Zn binding site [ion binding]; other site 41431006112 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431006113 active site 41431006114 metal binding site [ion binding]; metal-binding site 41431006115 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 41431006116 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431006117 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 41431006118 diaminopimelate epimerase; Region: PLN02536 41431006119 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 41431006120 S-layer homology domain; Region: SLH; pfam00395 41431006121 S-layer homology domain; Region: SLH; pfam00395 41431006122 S-layer homology domain; Region: SLH; pfam00395 41431006123 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 41431006124 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 41431006125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 41431006126 Helix-turn-helix domains; Region: HTH; cl00088 41431006127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 41431006128 dimerization interface [polypeptide binding]; other site 41431006129 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431006130 Ligand Binding Site [chemical binding]; other site 41431006131 aspartate aminotransferase; Provisional; Region: PRK05764 41431006132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431006133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431006134 homodimer interface [polypeptide binding]; other site 41431006135 catalytic residue [active] 41431006136 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 41431006137 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 41431006138 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431006139 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431006140 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 41431006141 homodimer interface [polypeptide binding]; other site 41431006142 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 41431006143 active site pocket [active] 41431006144 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 41431006145 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 41431006146 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 41431006147 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 41431006148 homodimer interface [polypeptide binding]; other site 41431006149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431006150 catalytic residue [active] 41431006151 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 41431006152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431006153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006154 active site 41431006155 phosphorylation site [posttranslational modification] 41431006156 intermolecular recognition site; other site 41431006157 dimerization interface [polypeptide binding]; other site 41431006158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431006159 DNA binding site [nucleotide binding] 41431006160 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 41431006161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006162 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 41431006163 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 41431006164 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 41431006165 G1 box; other site 41431006166 GTP/Mg2+ binding site [chemical binding]; other site 41431006167 Switch I region; other site 41431006168 G2 box; other site 41431006169 Switch II region; other site 41431006170 G3 box; other site 41431006171 G4 box; other site 41431006172 G5 box; other site 41431006173 Domain of unknown function (DUF697); Region: DUF697; cl12064 41431006174 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 41431006175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431006176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431006177 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 41431006178 catalytic residues [active] 41431006179 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 41431006180 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 41431006181 DNA binding site [nucleotide binding] 41431006182 active site 41431006183 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 41431006184 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 41431006185 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 41431006186 nudix motif; other site 41431006187 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 41431006188 dimer interface [polypeptide binding]; other site 41431006189 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431006190 metal binding site [ion binding]; metal-binding site 41431006191 glycogen branching enzyme; Provisional; Region: PRK12313 41431006192 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 41431006193 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 41431006194 active site 41431006195 catalytic site [active] 41431006196 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 41431006197 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 41431006198 dihydropteroate synthase; Region: DHPS; TIGR01496 41431006199 substrate binding pocket [chemical binding]; other site 41431006200 dimer interface [polypeptide binding]; other site 41431006201 inhibitor binding site; inhibition site 41431006202 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 41431006203 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 41431006204 minor groove reading motif; other site 41431006205 helix-hairpin-helix signature motif; other site 41431006206 substrate binding pocket [chemical binding]; other site 41431006207 active site 41431006208 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 41431006209 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 41431006210 active site 41431006211 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 41431006212 protein binding site [polypeptide binding]; other site 41431006213 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 41431006214 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921 41431006215 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 41431006216 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 41431006217 putative substrate binding site [chemical binding]; other site 41431006218 nucleotide binding site [chemical binding]; other site 41431006219 nucleotide binding site [chemical binding]; other site 41431006220 homodimer interface [polypeptide binding]; other site 41431006221 Predicted GTPase [General function prediction only]; Region: COG2403 41431006222 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 41431006223 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006224 active site 41431006225 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 41431006226 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 41431006227 inhibitor-cofactor binding pocket; inhibition site 41431006228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431006229 catalytic residue [active] 41431006230 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 41431006231 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 41431006232 active site residue [active] 41431006233 CbiD; Region: CbiD; cl00828 41431006234 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431006235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431006236 Coenzyme A binding pocket [chemical binding]; other site 41431006237 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 41431006238 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 41431006239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431006240 oligomerization interface [polypeptide binding]; other site 41431006241 active site 41431006242 NAD+ binding site [chemical binding]; other site 41431006243 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431006244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006245 active site 41431006246 phosphorylation site [posttranslational modification] 41431006247 intermolecular recognition site; other site 41431006248 dimerization interface [polypeptide binding]; other site 41431006249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431006250 DNA binding residues [nucleotide binding] 41431006251 dimerization interface [polypeptide binding]; other site 41431006252 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 41431006253 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 41431006254 FMN binding site [chemical binding]; other site 41431006255 active site 41431006256 catalytic residues [active] 41431006257 substrate binding site [chemical binding]; other site 41431006258 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431006259 Helix-turn-helix domains; Region: HTH; cl00088 41431006260 Domain of unknown function (DUF1821); Region: DUF1821; pfam08851 41431006261 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 41431006262 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 41431006263 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 41431006264 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431006265 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 41431006266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431006267 S-adenosylmethionine binding site [chemical binding]; other site 41431006268 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 41431006269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431006270 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 41431006271 putative L-serine binding site [chemical binding]; other site 41431006272 TIR domain; Region: TIR; cl02060 41431006273 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431006274 structural tetrad; other site 41431006275 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431006276 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431006277 structural tetrad; other site 41431006278 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 41431006279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431006280 S-adenosylmethionine binding site [chemical binding]; other site 41431006281 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 41431006282 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 41431006283 active site flap/lid [active] 41431006284 nucleophilic elbow; other site 41431006285 catalytic triad [active] 41431006286 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 41431006287 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 41431006288 classical (c) SDRs; Region: SDR_c; cd05233 41431006289 NAD(P) binding site [chemical binding]; other site 41431006290 active site 41431006291 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431006292 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431006293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 41431006294 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431006295 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006296 putative active site [active] 41431006297 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 41431006298 dimer interface [polypeptide binding]; other site 41431006299 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 41431006300 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 41431006301 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 41431006302 Walker A/P-loop; other site 41431006303 ATP binding site [chemical binding]; other site 41431006304 Q-loop/lid; other site 41431006305 ABC transporter signature motif; other site 41431006306 Walker B; other site 41431006307 D-loop; other site 41431006308 H-loop/switch region; other site 41431006309 PetN; Region: PetN; cl15376 41431006310 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 41431006311 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 41431006312 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006313 Walker A/P-loop; other site 41431006314 ATP binding site [chemical binding]; other site 41431006315 14-3-3 protein; Region: 14-3-3; cl02098 41431006316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006317 Q-loop/lid; other site 41431006318 ABC transporter signature motif; other site 41431006319 Walker B; other site 41431006320 D-loop; other site 41431006321 H-loop/switch region; other site 41431006322 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 41431006323 Active Sites [active] 41431006324 DGQHR domain; Region: DGQHR; cl14002 41431006325 DGQHR domain; Region: DGQHR; cl14002 41431006326 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006327 putative active site [active] 41431006328 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 41431006329 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 41431006330 phosphate binding site [ion binding]; other site 41431006331 putative substrate binding pocket [chemical binding]; other site 41431006332 dimer interface [polypeptide binding]; other site 41431006333 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 41431006334 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 41431006335 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 41431006336 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 41431006337 N-acetyl-D-glucosamine binding site [chemical binding]; other site 41431006338 catalytic residue [active] 41431006339 Protein of unknown function (DUF785); Region: DUF785; cl01682 41431006340 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 41431006341 endonuclease III; Region: ENDO3c; smart00478 41431006342 minor groove reading motif; other site 41431006343 helix-hairpin-helix signature motif; other site 41431006344 substrate binding pocket [chemical binding]; other site 41431006345 active site 41431006346 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431006347 putative acyl-acceptor binding pocket; other site 41431006348 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 41431006349 Protein of unknown function DUF111; Region: DUF111; cl03398 41431006350 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 41431006351 Cupin domain; Region: Cupin_2; cl09118 41431006352 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 41431006353 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 41431006354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006355 AAA-like domain; Region: AAA_10; pfam12846 41431006356 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 41431006357 dimer interface [polypeptide binding]; other site 41431006358 [2Fe-2S] cluster binding site [ion binding]; other site 41431006359 NeuB family; Region: NeuB; cl00496 41431006360 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 41431006361 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431006362 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431006363 active site 41431006364 ATP binding site [chemical binding]; other site 41431006365 substrate binding site [chemical binding]; other site 41431006366 activation loop (A-loop); other site 41431006367 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 41431006368 anti sigma factor interaction site; other site 41431006369 regulatory phosphorylation site [posttranslational modification]; other site 41431006370 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 41431006371 dimerization interface [polypeptide binding]; other site 41431006372 active site 41431006373 metal binding site [ion binding]; metal-binding site 41431006374 photosystem I P subunit (PSI-P); Region: PLN02777 41431006375 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 41431006376 active site 41431006377 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 41431006378 active site 41431006379 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 41431006380 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 41431006381 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 41431006382 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 41431006383 thioester formation/cholesterol transfer; other site 41431006384 protein-splicing catalytic site; other site 41431006385 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431006386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006387 active site 41431006388 phosphorylation site [posttranslational modification] 41431006389 intermolecular recognition site; other site 41431006390 dimerization interface [polypeptide binding]; other site 41431006391 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431006392 DNA binding residues [nucleotide binding] 41431006393 dimerization interface [polypeptide binding]; other site 41431006394 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 41431006395 Domain of unknown function DUF21; Region: DUF21; pfam01595 41431006396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 41431006397 Transporter associated domain; Region: CorC_HlyC; cl08393 41431006398 Penicillin amidase; Region: Penicil_amidase; pfam01804 41431006399 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 41431006400 active site 41431006401 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 41431006402 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 41431006403 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 41431006404 PKC phosphorylation site [posttranslational modification]; other site 41431006405 Cytochrome P450; Region: p450; cl12078 41431006406 Lipoxygenase; Region: Lipoxygenase; pfam00305 41431006407 Protein of unknown function (DUF497); Region: DUF497; cl01108 41431006408 Nuclease-related domain; Region: NERD; pfam08378 41431006409 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 41431006410 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006411 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006412 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 41431006413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431006414 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431006415 Coenzyme A binding pocket [chemical binding]; other site 41431006416 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431006417 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 41431006418 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 41431006419 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 41431006420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431006421 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 41431006422 Ion transport protein; Region: Ion_trans; pfam00520 41431006423 Ion channel; Region: Ion_trans_2; cl11596 41431006424 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006425 putative active site [active] 41431006426 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 41431006427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006428 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 41431006429 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 41431006430 Ferritin-like domain; Region: Ferritin; pfam00210 41431006431 dimerization interface [polypeptide binding]; other site 41431006432 DPS ferroxidase diiron center [ion binding]; other site 41431006433 ion pore; other site 41431006434 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 41431006435 dimer interface [polypeptide binding]; other site 41431006436 [2Fe-2S] cluster binding site [ion binding]; other site 41431006437 Domain of unknown function DUF; Region: DUF204; pfam02659 41431006438 Domain of unknown function DUF; Region: DUF204; pfam02659 41431006439 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431006440 Ligand Binding Site [chemical binding]; other site 41431006441 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431006442 Ligand Binding Site [chemical binding]; other site 41431006443 Protein kinase domain; Region: Pkinase; pfam00069 41431006444 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431006445 active site 41431006446 ATP binding site [chemical binding]; other site 41431006447 substrate binding site [chemical binding]; other site 41431006448 activation loop (A-loop); other site 41431006449 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 41431006450 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 41431006451 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 41431006452 putative valine binding site [chemical binding]; other site 41431006453 dimer interface [polypeptide binding]; other site 41431006454 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 41431006455 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006456 putative active site [active] 41431006457 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 41431006458 Microvirus H protein (pilot protein); Region: Microvir_H; cl11620 41431006459 major vault protein; Provisional; Region: PTZ00491 41431006460 CHAT domain; Region: CHAT; cl02083 41431006461 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 41431006462 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 41431006463 [4Fe-4S] binding site [ion binding]; other site 41431006464 molybdopterin cofactor binding site; other site 41431006465 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 41431006466 molybdopterin cofactor binding site; other site 41431006467 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 41431006468 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006469 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006470 putative active site [active] 41431006471 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431006472 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 41431006473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431006474 putative substrate translocation pore; other site 41431006475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431006476 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 41431006477 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 41431006478 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 41431006479 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431006480 hypothetical protein; Provisional; Region: PRK07394 41431006481 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 41431006482 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 41431006483 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 41431006484 homopentamer interface [polypeptide binding]; other site 41431006485 active site 41431006486 YCF9; Region: Ycf9; cl09269 41431006487 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431006488 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 41431006489 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 41431006490 N-terminal domain interface [polypeptide binding]; other site 41431006491 dimer interface [polypeptide binding]; other site 41431006492 substrate binding pocket (H-site) [chemical binding]; other site 41431006493 Uncharacterized conserved protein [Function unknown]; Region: COG2912 41431006494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431006495 binding surface 41431006496 TPR motif; other site 41431006497 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 41431006498 active site 41431006499 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 41431006500 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 41431006501 Phd_YefM; Region: PhdYeFM; cl09153 41431006502 TIR domain; Region: TIR; cl02060 41431006503 Uncharacterized conserved protein [Function unknown]; Region: COG1262 41431006504 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 41431006505 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 41431006506 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 41431006507 [2Fe-2S] cluster binding site [ion binding]; other site 41431006508 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 41431006509 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 41431006510 metal binding site [ion binding]; metal-binding site 41431006511 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 41431006512 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 41431006513 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 41431006514 YcfA-like protein; Region: YcfA; cl00752 41431006515 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431006516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431006517 binding surface 41431006518 TPR motif; other site 41431006519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431006520 TPR motif; other site 41431006521 binding surface 41431006522 CHAT domain; Region: CHAT; cl02083 41431006523 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 41431006524 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 41431006525 CHAD domain; Region: CHAD; cl10506 41431006526 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 41431006527 active site 41431006528 putative lithium-binding site [ion binding]; other site 41431006529 substrate binding site [chemical binding]; other site 41431006530 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 41431006531 DHH family; Region: DHH; pfam01368 41431006532 DHHA1 domain; Region: DHHA1; pfam02272 41431006533 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 41431006534 MatE; Region: MatE; cl10513 41431006535 MatE; Region: MatE; cl10513 41431006536 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 41431006537 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 41431006538 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 41431006539 substrate binding pocket [chemical binding]; other site 41431006540 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 41431006541 B12 binding site [chemical binding]; other site 41431006542 cobalt ligand [ion binding]; other site 41431006543 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 41431006544 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 41431006545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431006546 S-adenosylmethionine binding site [chemical binding]; other site 41431006547 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 41431006548 hydrophobic ligand binding site; other site 41431006549 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431006550 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 41431006551 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 41431006552 CoA-binding site [chemical binding]; other site 41431006553 ATP-binding [chemical binding]; other site 41431006554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 41431006555 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 41431006556 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 41431006557 TPP-binding site [chemical binding]; other site 41431006558 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 41431006559 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431006560 active site 41431006561 ATP binding site [chemical binding]; other site 41431006562 substrate binding site [chemical binding]; other site 41431006563 activation loop (A-loop); other site 41431006564 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006565 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431006567 cofactor binding site; other site 41431006568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431006569 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 41431006570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431006571 dimer interface [polypeptide binding]; other site 41431006572 ABC-ATPase subunit interface; other site 41431006573 putative PBP binding loops; other site 41431006574 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 41431006575 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 41431006576 inhibitor-cofactor binding pocket; inhibition site 41431006577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431006578 catalytic residue [active] 41431006579 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 41431006580 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 41431006581 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 41431006582 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 41431006583 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 41431006584 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 41431006585 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 41431006586 Nucleotide binding site [chemical binding]; other site 41431006587 DTAP/Switch II; other site 41431006588 Switch I; other site 41431006589 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006590 putative active site [active] 41431006591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431006592 catalytic core [active] 41431006593 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431006594 catalytic core [active] 41431006595 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 41431006596 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431006597 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 41431006598 YGGT family; Region: YGGT; cl00508 41431006599 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 41431006600 Domain of unknown function DUF20; Region: UPF0118; cl00465 41431006601 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 41431006602 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006603 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006604 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 41431006605 GTP-binding protein Era; Region: era; TIGR00436 41431006606 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 41431006607 G4 box; other site 41431006608 Domain of unknown function (DUF697); Region: DUF697; cl12064 41431006609 GTP-binding protein LepA; Provisional; Region: PRK05433 41431006610 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 41431006611 G1 box; other site 41431006612 putative GEF interaction site [polypeptide binding]; other site 41431006613 GTP/Mg2+ binding site [chemical binding]; other site 41431006614 Switch I region; other site 41431006615 G2 box; other site 41431006616 G3 box; other site 41431006617 Switch II region; other site 41431006618 G4 box; other site 41431006619 G5 box; other site 41431006620 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 41431006621 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 41431006622 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 41431006623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431006624 binding surface 41431006625 TPR motif; other site 41431006626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431006627 binding surface 41431006628 TPR motif; other site 41431006629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431006630 PsbP; Region: PsbP; cl03356 41431006631 Maf-like protein; Region: Maf; pfam02545 41431006632 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 41431006633 active site 41431006634 dimer interface [polypeptide binding]; other site 41431006635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006636 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 41431006637 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 41431006638 homodimer interface [polypeptide binding]; other site 41431006639 Walker A motif; other site 41431006640 ATP binding site [chemical binding]; other site 41431006641 hydroxycobalamin binding site [chemical binding]; other site 41431006642 Walker B motif; other site 41431006643 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006644 putative active site [active] 41431006645 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 41431006646 Phd_YefM; Region: PhdYeFM; cl09153 41431006647 RNA polymerase sigma factor; Validated; Region: PRK05949 41431006648 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 41431006649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431006650 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431006651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431006652 DNA binding residues [nucleotide binding] 41431006653 Domain of unknown function DUF39; Region: DUF39; cl14897 41431006654 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 41431006655 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 41431006656 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 41431006657 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 41431006658 dimerization interface [polypeptide binding]; other site 41431006659 FAD binding pocket [chemical binding]; other site 41431006660 FAD binding motif [chemical binding]; other site 41431006661 catalytic residues [active] 41431006662 NAD binding pocket [chemical binding]; other site 41431006663 phosphate binding motif [ion binding]; other site 41431006664 beta-alpha-beta structure motif; other site 41431006665 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 41431006666 putative active site [active] 41431006667 putative metal binding residues [ion binding]; other site 41431006668 signature motif; other site 41431006669 putative dimer interface [polypeptide binding]; other site 41431006670 putative phosphate binding site [ion binding]; other site 41431006671 GTPase Era; Reviewed; Region: era; PRK00089 41431006672 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 41431006673 G1 box; other site 41431006674 GTP/Mg2+ binding site [chemical binding]; other site 41431006675 Switch I region; other site 41431006676 G2 box; other site 41431006677 Switch II region; other site 41431006678 G3 box; other site 41431006679 G4 box; other site 41431006680 G5 box; other site 41431006681 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 41431006682 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 41431006683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431006684 ATP binding site [chemical binding]; other site 41431006685 Mg2+ binding site [ion binding]; other site 41431006686 G-X-G motif; other site 41431006687 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 41431006688 Response regulator receiver domain; Region: Response_reg; pfam00072 41431006689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006690 active site 41431006691 phosphorylation site [posttranslational modification] 41431006692 intermolecular recognition site; other site 41431006693 dimerization interface [polypeptide binding]; other site 41431006694 Response regulator receiver domain; Region: Response_reg; pfam00072 41431006695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006696 active site 41431006697 phosphorylation site [posttranslational modification] 41431006698 intermolecular recognition site; other site 41431006699 dimerization interface [polypeptide binding]; other site 41431006700 calcium/proton exchanger (cax); Region: cax; TIGR00378 41431006701 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 41431006702 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 41431006703 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 41431006704 PhoU domain; Region: PhoU; pfam01895 41431006705 PhoU domain; Region: PhoU; pfam01895 41431006706 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 41431006707 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 41431006708 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 41431006709 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 41431006710 FAD binding domain; Region: FAD_binding_4; pfam01565 41431006711 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 41431006712 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 41431006713 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 41431006714 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 41431006715 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431006716 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 41431006717 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 41431006718 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 41431006719 GUN4-like; Region: GUN4; pfam05419 41431006720 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 41431006721 putative nucleotide binding site [chemical binding]; other site 41431006722 uridine monophosphate binding site [chemical binding]; other site 41431006723 homohexameric interface [polypeptide binding]; other site 41431006724 ribosome recycling factor; Reviewed; Region: frr; PRK00083 41431006725 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 41431006726 hinge region; other site 41431006727 GDP-mannose 4,6-dehydratase; Region: PLN02653 41431006728 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 41431006729 NADP-binding site; other site 41431006730 homotetramer interface [polypeptide binding]; other site 41431006731 substrate binding site [chemical binding]; other site 41431006732 homodimer interface [polypeptide binding]; other site 41431006733 active site 41431006734 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 41431006735 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 41431006736 NADP binding site [chemical binding]; other site 41431006737 active site 41431006738 putative substrate binding site [chemical binding]; other site 41431006739 Protein of unknown function (DUF952); Region: DUF952; cl01393 41431006740 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 41431006741 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 41431006742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 41431006743 Cache domain; Region: Cache_1; pfam02743 41431006744 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 41431006745 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 41431006746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431006747 putative active site [active] 41431006748 heme pocket [chemical binding]; other site 41431006749 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 41431006750 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 41431006751 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 41431006752 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 41431006753 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 41431006754 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 41431006755 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 41431006756 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 41431006757 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 41431006758 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 41431006759 ATP-binding site [chemical binding]; other site 41431006760 Gluconate-6-phosphate binding site [chemical binding]; other site 41431006761 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 41431006762 rRNA interaction site [nucleotide binding]; other site 41431006763 S8 interaction site; other site 41431006764 putative laminin-1 binding site; other site 41431006765 elongation factor Ts; Reviewed; Region: tsf; PRK12332 41431006766 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 41431006767 Elongation factor TS; Region: EF_TS; pfam00889 41431006768 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431006769 pyruvate kinase; Provisional; Region: PRK06354 41431006770 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 41431006771 domain interfaces; other site 41431006772 active site 41431006773 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 41431006774 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 41431006775 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431006776 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 41431006777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006778 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 41431006779 Walker A/P-loop; other site 41431006780 ATP binding site [chemical binding]; other site 41431006781 Q-loop/lid; other site 41431006782 ABC transporter signature motif; other site 41431006783 Walker B; other site 41431006784 D-loop; other site 41431006785 H-loop/switch region; other site 41431006786 ABC-2 type transporter; Region: ABC2_membrane; cl11417 41431006787 electron transport complex protein RnfB; Provisional; Region: PRK05113 41431006788 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 41431006789 substrate binding site [chemical binding]; other site 41431006790 NurA domain; Region: NurA; cl09134 41431006791 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431006792 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431006793 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431006794 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 41431006795 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 41431006796 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 41431006797 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 41431006798 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 41431006799 putative active site [active] 41431006800 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 41431006801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431006802 FeS/SAM binding site; other site 41431006803 HemN C-terminal region; Region: HemN_C; pfam06969 41431006804 Flavin Reductases; Region: FlaRed; cl00801 41431006805 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 41431006806 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 41431006807 ribosomal protein L20; Region: rpl20; CHL00068 41431006808 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 41431006809 23S rRNA binding site [nucleotide binding]; other site 41431006810 L21 binding site [polypeptide binding]; other site 41431006811 L13 binding site [polypeptide binding]; other site 41431006812 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 41431006813 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 41431006814 LytB protein; Region: LYTB; cl00507 41431006815 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 41431006816 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 41431006817 Domain of unknown function DUF21; Region: DUF21; pfam01595 41431006818 FOG: CBS domain [General function prediction only]; Region: COG0517 41431006819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 41431006820 heat shock protein 90; Provisional; Region: PRK05218 41431006821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431006822 ATP binding site [chemical binding]; other site 41431006823 Mg2+ binding site [ion binding]; other site 41431006824 G-X-G motif; other site 41431006825 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 41431006826 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 41431006827 catalytic motif [active] 41431006828 Catalytic residue [active] 41431006829 Protein of unknown function DUF262; Region: DUF262; cl14890 41431006830 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006831 putative active site [active] 41431006832 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 41431006833 Response regulator receiver domain; Region: Response_reg; pfam00072 41431006834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006835 active site 41431006836 phosphorylation site [posttranslational modification] 41431006837 intermolecular recognition site; other site 41431006838 dimerization interface [polypeptide binding]; other site 41431006839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431006840 DNA binding residues [nucleotide binding] 41431006841 MASE1; Region: MASE1; pfam05231 41431006842 GAF domain; Region: GAF; cl00853 41431006843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431006844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431006845 dimer interface [polypeptide binding]; other site 41431006846 phosphorylation site [posttranslational modification] 41431006847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431006848 ATP binding site [chemical binding]; other site 41431006849 Mg2+ binding site [ion binding]; other site 41431006850 G-X-G motif; other site 41431006851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431006852 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 41431006853 Tup N-terminal; Region: Tup_N; pfam08581 41431006854 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006855 putative active site [active] 41431006856 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 41431006857 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 41431006858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431006859 dimer interface [polypeptide binding]; other site 41431006860 phosphorylation site [posttranslational modification] 41431006861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431006862 Coenzyme A binding pocket [chemical binding]; other site 41431006863 NlpC/P60 family; Region: NLPC_P60; cl11438 41431006864 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 41431006865 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 41431006866 putative dimer interface [polypeptide binding]; other site 41431006867 Integral membrane protein DUF92; Region: DUF92; cl00793 41431006868 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 41431006869 N- and C-terminal domain interface [polypeptide binding]; other site 41431006870 D-xylulose kinase; Region: XylB; TIGR01312 41431006871 active site 41431006872 MgATP binding site [chemical binding]; other site 41431006873 catalytic site [active] 41431006874 metal binding site [ion binding]; metal-binding site 41431006875 carbohydrate binding site [chemical binding]; other site 41431006876 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 41431006877 nudix motif; other site 41431006878 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 41431006879 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 41431006880 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 41431006881 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 41431006882 Ycf46; Provisional; Region: ycf46; CHL00195 41431006883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431006884 Walker A motif; other site 41431006885 ATP binding site [chemical binding]; other site 41431006886 Walker B motif; other site 41431006887 arginine finger; other site 41431006888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431006889 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 41431006890 substrate binding pocket [chemical binding]; other site 41431006891 membrane-bound complex binding site; other site 41431006892 hinge residues; other site 41431006893 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 41431006894 histidinol dehydrogenase; Region: hisD; TIGR00069 41431006895 NAD binding site [chemical binding]; other site 41431006896 dimerization interface [polypeptide binding]; other site 41431006897 product binding site; other site 41431006898 substrate binding site [chemical binding]; other site 41431006899 zinc binding site [ion binding]; other site 41431006900 catalytic residues [active] 41431006901 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 41431006902 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 41431006903 Catalytic site [active] 41431006904 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 41431006905 AIR carboxylase; Region: AIRC; cl00310 41431006906 Protein of function (DUF2518); Region: DUF2518; pfam10726 41431006907 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431006908 phosphopeptide binding site; other site 41431006909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431006910 metal binding site [ion binding]; metal-binding site 41431006911 active site 41431006912 I-site; other site 41431006913 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431006914 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431006915 phosphopeptide binding site; other site 41431006916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431006917 metal binding site [ion binding]; metal-binding site 41431006918 active site 41431006919 I-site; other site 41431006920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431006921 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431006922 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431006923 P-loop; other site 41431006924 Magnesium ion binding site [ion binding]; other site 41431006925 MEKHLA domain; Region: MEKHLA; pfam08670 41431006926 XisH protein; Region: XisH; pfam08814 41431006927 XisI protein; Region: XisI; pfam08869 41431006928 ThiC family; Region: ThiC; cl08031 41431006929 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 41431006930 putative active site [active] 41431006931 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 41431006932 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 41431006933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431006934 ABC-ATPase subunit interface; other site 41431006935 putative PBP binding loops; other site 41431006936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 41431006937 Domain of unknown function DUF20; Region: UPF0118; cl00465 41431006938 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431006939 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 41431006940 substrate binding pocket [chemical binding]; other site 41431006941 membrane-bound complex binding site; other site 41431006942 hinge residues; other site 41431006943 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 41431006944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 41431006945 Family of unknown function (DUF490); Region: DUF490; pfam04357 41431006946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431006947 TPR motif; other site 41431006948 binding surface 41431006949 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 41431006950 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431006951 ribose-phosphate pyrophosphokinase; Region: PLN02369 41431006952 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431006953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 41431006954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 41431006955 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 41431006956 ligand binding site [chemical binding]; other site 41431006957 flexible hinge region; other site 41431006958 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 41431006959 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 41431006960 putative active site [active] 41431006961 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 41431006962 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 41431006963 Walker A/P-loop; other site 41431006964 ATP binding site [chemical binding]; other site 41431006965 Q-loop/lid; other site 41431006966 ABC transporter signature motif; other site 41431006967 Walker B; other site 41431006968 D-loop; other site 41431006969 H-loop/switch region; other site 41431006970 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 41431006971 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 41431006972 E3 interaction surface; other site 41431006973 lipoyl attachment site [posttranslational modification]; other site 41431006974 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 41431006975 PPIC-type PPIASE domain; Region: Rotamase; cl08278 41431006976 Phosphotransferase enzyme family; Region: APH; pfam01636 41431006977 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 41431006978 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 41431006979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431006980 FeS/SAM binding site; other site 41431006981 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 41431006982 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 41431006983 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 41431006984 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 41431006985 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 41431006986 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006987 putative active site [active] 41431006988 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 41431006989 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 41431006990 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 41431006991 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 41431006992 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431006993 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006994 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006995 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006996 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006997 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 41431006998 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 41431006999 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 41431007000 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431007001 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007002 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007003 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007004 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007005 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007006 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007007 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431007008 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 41431007009 active site 41431007010 metal binding site [ion binding]; metal-binding site 41431007011 TIR domain; Region: TIR; cl02060 41431007012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431007013 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 41431007014 Walker A/P-loop; other site 41431007015 ATP binding site [chemical binding]; other site 41431007016 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 41431007017 nucleoside/Zn binding site; other site 41431007018 dimer interface [polypeptide binding]; other site 41431007019 catalytic motif [active] 41431007020 Predicted ATPase [General function prediction only]; Region: COG4637 41431007021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431007022 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 41431007023 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 41431007024 HIGH motif; other site 41431007025 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 41431007026 active site 41431007027 KMSKS motif; other site 41431007028 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 41431007029 tRNA binding surface [nucleotide binding]; other site 41431007030 anticodon binding site; other site 41431007031 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 41431007032 Protein of unknown function (DUF3532); Region: DUF3532; pfam12050 41431007033 translation initiation factor IF-2; Validated; Region: infB; PRK05306 41431007034 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 41431007035 translation initiation factor IF-2; Region: IF-2; TIGR00487 41431007036 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 41431007037 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 41431007038 G1 box; other site 41431007039 putative GEF interaction site [polypeptide binding]; other site 41431007040 GTP/Mg2+ binding site [chemical binding]; other site 41431007041 Switch I region; other site 41431007042 G2 box; other site 41431007043 G3 box; other site 41431007044 Switch II region; other site 41431007045 G4 box; other site 41431007046 G5 box; other site 41431007047 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 41431007048 Translation-initiation factor 2; Region: IF-2; pfam11987 41431007049 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 41431007050 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 41431007051 putative RNA binding cleft [nucleotide binding]; other site 41431007052 transcription elongation factor NusA; Provisional; Region: nusA; PRK12329 41431007053 NusA N-terminal domain; Region: NusA_N; pfam08529 41431007054 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 41431007055 RNA binding site [nucleotide binding]; other site 41431007056 homodimer interface [polypeptide binding]; other site 41431007057 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 41431007058 G-X-X-G motif; other site 41431007059 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 41431007060 G-X-X-G motif; other site 41431007061 ribosome maturation protein RimP; Reviewed; Region: PRK00092 41431007062 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 41431007063 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 41431007064 Sm1 motif; other site 41431007065 D3 - B interaction site; other site 41431007066 D1 - D2 interaction site; other site 41431007067 Hfq - Hfq interaction site; other site 41431007068 RNA binding pocket [nucleotide binding]; other site 41431007069 Sm2 motif; other site 41431007070 ATP synthase I chain; Region: ATP_synt_I; cl09170 41431007071 ATP synthase A chain; Region: ATP-synt_A; cl00413 41431007072 ATP synthase subunit C; Region: ATP-synt_C; cl00466 41431007073 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 41431007074 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 41431007075 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 41431007076 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 41431007077 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 41431007078 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 41431007079 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 41431007080 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 41431007081 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 41431007082 beta subunit interaction interface [polypeptide binding]; other site 41431007083 Walker A motif; other site 41431007084 ATP binding site [chemical binding]; other site 41431007085 Walker B motif; other site 41431007086 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 41431007087 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 41431007088 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 41431007089 Low molecular weight phosphatase family; Region: LMWPc; cd00115 41431007090 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 41431007091 active site 41431007092 Peptidase family M48; Region: Peptidase_M48; cl12018 41431007093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431007094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 41431007095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431007096 dimer interface [polypeptide binding]; other site 41431007097 phosphorylation site [posttranslational modification] 41431007098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431007099 ATP binding site [chemical binding]; other site 41431007100 Mg2+ binding site [ion binding]; other site 41431007101 G-X-G motif; other site 41431007102 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 41431007103 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 41431007104 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431007105 Walker A/P-loop; other site 41431007106 ATP binding site [chemical binding]; other site 41431007107 Q-loop/lid; other site 41431007108 ABC transporter signature motif; other site 41431007109 Walker B; other site 41431007110 D-loop; other site 41431007111 H-loop/switch region; other site 41431007112 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 41431007113 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 41431007114 active site 41431007115 Ca binding site [ion binding]; other site 41431007116 catalytic site [active] 41431007117 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 41431007118 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431007119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431007120 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431007121 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431007122 ligand binding site [chemical binding]; other site 41431007123 flexible hinge region; other site 41431007124 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 41431007125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431007126 S-adenosylmethionine binding site [chemical binding]; other site 41431007127 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 41431007128 MutS domain I; Region: MutS_I; pfam01624 41431007129 MutS domain II; Region: MutS_II; pfam05188 41431007130 MutS family domain IV; Region: MutS_IV; pfam05190 41431007131 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 41431007132 Walker A/P-loop; other site 41431007133 ATP binding site [chemical binding]; other site 41431007134 Q-loop/lid; other site 41431007135 ABC transporter signature motif; other site 41431007136 Walker B; other site 41431007137 D-loop; other site 41431007138 H-loop/switch region; other site 41431007139 Integral membrane protein TerC family; Region: TerC; cl10468 41431007140 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 41431007141 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 41431007142 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 41431007143 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 41431007144 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 41431007145 Amidinotransferase; Region: Amidinotransf; cl12043 41431007146 Uncharacterized conserved protein [Function unknown]; Region: COG1915 41431007147 LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455 41431007148 Response regulator receiver domain; Region: Response_reg; pfam00072 41431007149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431007150 active site 41431007151 phosphorylation site [posttranslational modification] 41431007152 intermolecular recognition site; other site 41431007153 dimerization interface [polypeptide binding]; other site 41431007154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 41431007155 dimer interface [polypeptide binding]; other site 41431007156 phosphorylation site [posttranslational modification] 41431007157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431007158 ATP binding site [chemical binding]; other site 41431007159 Mg2+ binding site [ion binding]; other site 41431007160 G-X-G motif; other site 41431007161 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 41431007162 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 41431007163 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 41431007164 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 41431007165 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 41431007166 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 41431007167 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 41431007168 Walker A/P-loop; other site 41431007169 ATP binding site [chemical binding]; other site 41431007170 Q-loop/lid; other site 41431007171 ABC transporter signature motif; other site 41431007172 Walker B; other site 41431007173 D-loop; other site 41431007174 H-loop/switch region; other site 41431007175 sulfate transport protein; Provisional; Region: cysT; CHL00187 41431007176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431007177 dimer interface [polypeptide binding]; other site 41431007178 conserved gate region; other site 41431007179 putative PBP binding loops; other site 41431007180 ABC-ATPase subunit interface; other site 41431007181 sulfate ABC transporter, permease protein CysT; Region: permease_CysT; TIGR02139 41431007182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431007183 dimer interface [polypeptide binding]; other site 41431007184 conserved gate region; other site 41431007185 putative PBP binding loops; other site 41431007186 ABC-ATPase subunit interface; other site 41431007187 NIL domain; Region: NIL; cl09633 41431007188 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 41431007189 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431007190 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 41431007191 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 41431007192 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 41431007193 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431007194 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431007195 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 41431007196 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 41431007197 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 41431007198 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 41431007199 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 41431007200 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 41431007201 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 41431007202 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 41431007203 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 41431007204 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 41431007205 putative active site [active] 41431007206 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 41431007207 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 41431007208 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 41431007209 Substrate binding site; other site 41431007210 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 41431007211 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 41431007212 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 41431007213 active site 41431007214 ATP binding site [chemical binding]; other site 41431007215 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 41431007216 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 41431007217 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 41431007218 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 41431007219 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431007220 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 41431007221 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 41431007222 Walker A motif; other site 41431007223 ATP binding site [chemical binding]; other site 41431007224 Walker B motif; other site 41431007225 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 41431007226 tetramer interface [polypeptide binding]; other site 41431007227 dimer interface [polypeptide binding]; other site 41431007228 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431007229 catalytic loop [active] 41431007230 iron binding site [ion binding]; other site 41431007231 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431007232 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 41431007233 putative ADP-binding pocket [chemical binding]; other site 41431007234 Bacterial sugar transferase; Region: Bac_transf; cl00939 41431007235 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 41431007236 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 41431007237 Phycobilisome protein; Region: Phycobilisome; cl08227 41431007238 Phycobilisome protein; Region: Phycobilisome; cl08227 41431007239 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 41431007240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431007241 catalytic core [active] 41431007242 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431007243 catalytic core [active] 41431007244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431007245 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431007246 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 41431007247 cofactor binding site; other site 41431007248 DNA binding site [nucleotide binding] 41431007249 substrate interaction site [chemical binding]; other site 41431007250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007251 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 41431007252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007253 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 41431007254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431007255 Walker A motif; other site 41431007256 ATP binding site [chemical binding]; other site 41431007257 Walker B motif; other site 41431007258 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 41431007259 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 41431007260 Transposase; Region: HTH_Tnp_IS630; pfam01710 41431007261 Integrase core domain; Region: rve; cl01316 41431007262 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 41431007263 homodimer interface [polypeptide binding]; other site 41431007264 substrate-cofactor binding pocket; other site 41431007265 Aminotransferase class IV; Region: Aminotran_4; pfam01063 41431007266 catalytic residue [active] 41431007267 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 41431007268 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 41431007269 Zn binding site [ion binding]; other site 41431007270 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 41431007271 protein binding site [polypeptide binding]; other site 41431007272 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431007273 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431007274 ligand binding site [chemical binding]; other site 41431007275 flexible hinge region; other site 41431007276 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 41431007277 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 41431007278 putative di-iron ligands [ion binding]; other site 41431007279 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431007280 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 41431007281 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 41431007282 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431007283 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 41431007284 Predicted kinase [General function prediction only]; Region: COG0645 41431007285 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 41431007286 ATP-binding site [chemical binding]; other site 41431007287 Gluconate-6-phosphate binding site [chemical binding]; other site 41431007288 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007289 putative active site [active] 41431007290 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 41431007291 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431007292 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 41431007293 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 41431007294 transmembrane helices; other site 41431007295 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431007296 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 41431007297 active site 41431007298 putative substrate binding region [chemical binding]; other site 41431007299 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007300 putative active site [active] 41431007301 chaperone protein DnaJ; Provisional; Region: PRK14299 41431007302 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431007303 HSP70 interaction site [polypeptide binding]; other site 41431007304 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 41431007305 substrate binding site [polypeptide binding]; other site 41431007306 dimer interface [polypeptide binding]; other site 41431007307 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 41431007308 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431007309 P-loop; other site 41431007310 Magnesium ion binding site [ion binding]; other site 41431007311 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 41431007312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431007313 non-specific DNA binding site [nucleotide binding]; other site 41431007314 salt bridge; other site 41431007315 sequence-specific DNA binding site [nucleotide binding]; other site 41431007316 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 41431007317 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 41431007318 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 41431007319 dimerization interface [polypeptide binding]; other site 41431007320 active site 41431007321 metal binding site [ion binding]; metal-binding site 41431007322 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 41431007323 dsRNA binding site [nucleotide binding]; other site 41431007324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431007325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431007326 S-adenosylmethionine binding site [chemical binding]; other site 41431007327 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 41431007328 putative ADP-binding pocket [chemical binding]; other site 41431007329 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431007330 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 41431007331 SH3 domain-containing protein; Provisional; Region: PRK10884 41431007332 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 41431007333 Domain of unknown function (DUF205); Region: DUF205; cl00410 41431007334 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 41431007335 SWIM zinc finger; Region: SWIM; cl15408 41431007336 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431007337 active site 41431007338 NTP binding site [chemical binding]; other site 41431007339 metal binding triad [ion binding]; metal-binding site 41431007340 antibiotic binding site [chemical binding]; other site 41431007341 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 41431007342 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 41431007343 putative tRNA-binding site [nucleotide binding]; other site 41431007344 B3/4 domain; Region: B3_4; cl11458 41431007345 tRNA synthetase B5 domain; Region: B5; cl08394 41431007346 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 41431007347 dimer interface [polypeptide binding]; other site 41431007348 motif 1; other site 41431007349 motif 3; other site 41431007350 motif 2; other site 41431007351 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 41431007352 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431007353 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431007354 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007355 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007356 thiamine monophosphate kinase; Provisional; Region: PRK05731 41431007357 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 41431007358 ATP binding site [chemical binding]; other site 41431007359 dimerization interface [polypeptide binding]; other site 41431007360 Domain of unknown function (DUF389); Region: DUF389; cl00781 41431007361 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 41431007362 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 41431007363 Active site cavity [active] 41431007364 catalytic acid [active] 41431007365 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431007366 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 41431007367 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 41431007368 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431007369 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 41431007370 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431007371 RNA binding surface [nucleotide binding]; other site 41431007372 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 41431007373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431007374 FeS/SAM binding site; other site 41431007375 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 41431007376 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431007377 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431007378 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431007379 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 41431007380 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 41431007381 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 41431007382 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 41431007383 RNA binding site [nucleotide binding]; other site 41431007384 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 41431007385 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 41431007386 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 41431007387 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431007388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431007389 Probable transposase; Region: OrfB_IS605; pfam01385 41431007390 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431007391 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 41431007392 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 41431007393 ring oligomerisation interface [polypeptide binding]; other site 41431007394 ATP/Mg binding site [chemical binding]; other site 41431007395 stacking interactions; other site 41431007396 hinge regions; other site 41431007397 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 41431007398 oligomerisation interface [polypeptide binding]; other site 41431007399 mobile loop; other site 41431007400 roof hairpin; other site 41431007401 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 41431007402 Predicted ATPase [General function prediction only]; Region: COG4637 41431007403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431007404 Walker A/P-loop; other site 41431007405 ATP binding site [chemical binding]; other site 41431007406 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431007407 Q-loop/lid; other site 41431007408 ABC transporter signature motif; other site 41431007409 Walker B; other site 41431007410 D-loop; other site 41431007411 H-loop/switch region; other site 41431007412 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 41431007413 conserved cys residue [active] 41431007414 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431007415 catalytic loop [active] 41431007416 iron binding site [ion binding]; other site 41431007417 Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459 41431007418 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 41431007419 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 41431007420 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 41431007421 inhibitor-cofactor binding pocket; inhibition site 41431007422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431007423 catalytic residue [active] 41431007424 Bacitracin resistance protein BacA; Region: BacA; cl00858 41431007425 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431007426 anthranilate synthase component I-like protein; Validated; Region: PRK05940 41431007427 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 41431007428 chorismate binding enzyme; Region: Chorismate_bind; cl10555 41431007429 Cobalt transport protein; Region: CbiQ; cl00463 41431007430 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 41431007431 putative active site [active] 41431007432 catalytic site [active] 41431007433 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 41431007434 putative active site [active] 41431007435 catalytic site [active] 41431007436 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 41431007437 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 41431007438 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 41431007439 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 41431007440 dimerization interface [polypeptide binding]; other site 41431007441 domain crossover interface; other site 41431007442 redox-dependent activation switch; other site 41431007443 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 41431007444 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 41431007445 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431007446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431007447 Probable transposase; Region: OrfB_IS605; pfam01385 41431007448 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431007449 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 41431007450 30S subunit binding site; other site 41431007451 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 41431007452 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 41431007453 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 41431007454 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 41431007455 protein binding site [polypeptide binding]; other site 41431007456 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 41431007457 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431007458 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007459 putative active site [active] 41431007460 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 41431007461 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 41431007462 alpha subunit interface [polypeptide binding]; other site 41431007463 TPP binding site [chemical binding]; other site 41431007464 heterodimer interface [polypeptide binding]; other site 41431007465 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 41431007466 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 41431007467 Protein export membrane protein; Region: SecD_SecF; cl14618 41431007468 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 41431007469 Protein export membrane protein; Region: SecD_SecF; cl14618 41431007470 iron-sulfur cluster binding protein, putative; Region: TIGR00276 41431007471 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 41431007472 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 41431007473 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 41431007474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431007475 motif II; other site 41431007476 MAPEG family; Region: MAPEG; cl09190 41431007477 Response regulator receiver domain; Region: Response_reg; pfam00072 41431007478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431007479 active site 41431007480 phosphorylation site [posttranslational modification] 41431007481 intermolecular recognition site; other site 41431007482 dimerization interface [polypeptide binding]; other site 41431007483 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431007484 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 41431007485 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 41431007486 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 41431007487 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 41431007488 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 41431007489 Malic enzyme, N-terminal domain; Region: malic; pfam00390 41431007490 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 41431007491 putative NAD(P) binding site [chemical binding]; other site 41431007492 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 41431007493 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 41431007494 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 41431007495 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 41431007496 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 41431007497 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 41431007498 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 41431007499 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 41431007500 active site 41431007501 catalytic tetrad [active] 41431007502 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 41431007503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007504 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 41431007505 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 41431007506 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 41431007507 active site 41431007508 HIGH motif; other site 41431007509 dimer interface [polypeptide binding]; other site 41431007510 KMSKS motif; other site 41431007511 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 41431007512 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431007513 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 41431007514 Walker A/P-loop; other site 41431007515 ATP binding site [chemical binding]; other site 41431007516 Q-loop/lid; other site 41431007517 ABC transporter signature motif; other site 41431007518 Walker B; other site 41431007519 D-loop; other site 41431007520 H-loop/switch region; other site 41431007521 YacP-like NYN domain; Region: NYN_YacP; cl01491 41431007522 hypothetical protein; Validated; Region: PRK07411 41431007523 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 41431007524 ATP binding site [chemical binding]; other site 41431007525 substrate interface [chemical binding]; other site 41431007526 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 41431007527 active site residue [active] 41431007528 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 41431007529 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 41431007530 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 41431007531 HicB family; Region: HicB; pfam05534 41431007532 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 41431007533 MPN+ (JAMM) motif; other site 41431007534 Zinc-binding site [ion binding]; other site 41431007535 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 41431007536 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 41431007537 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 41431007538 Ion channel; Region: Ion_trans_2; cl11596 41431007539 Chorismate mutase type II; Region: CM_2; cl00693 41431007540 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 41431007541 active site 41431007542 Mg chelatase-related protein; Region: TIGR00368 41431007543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431007544 Walker A motif; other site 41431007545 ATP binding site [chemical binding]; other site 41431007546 Walker B motif; other site 41431007547 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 41431007548 Tic22-like family; Region: Tic22; cl04468 41431007549 Tic22-like family; Region: Tic22; cl04468 41431007550 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 41431007551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431007552 S-adenosylmethionine binding site [chemical binding]; other site 41431007553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 41431007554 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 41431007555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 41431007556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 41431007557 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 41431007558 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431007559 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431007560 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 41431007561 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 41431007562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431007563 Walker A motif; other site 41431007564 ATP binding site [chemical binding]; other site 41431007565 Walker B motif; other site 41431007566 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 41431007567 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 41431007568 oligomer interface [polypeptide binding]; other site 41431007569 active site residues [active] 41431007570 trigger factor; Provisional; Region: tig; PRK01490 41431007571 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 41431007572 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 41431007573 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 41431007574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007575 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 41431007576 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 41431007577 dihydrodipicolinate synthase; Region: dapA; TIGR00674 41431007578 dimer interface [polypeptide binding]; other site 41431007579 active site 41431007580 catalytic residue [active] 41431007581 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 41431007582 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431007583 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 41431007584 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007585 putative active site [active] 41431007586 Vitamin K epoxide reductase family; Region: VKOR; cl01729 41431007587 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 41431007588 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431007589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431007590 S-adenosylmethionine binding site [chemical binding]; other site 41431007591 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 41431007592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431007593 active site 41431007594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431007595 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431007596 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 41431007597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431007598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431007599 homodimer interface [polypeptide binding]; other site 41431007600 catalytic residue [active] 41431007601 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 41431007602 IHF dimer interface [polypeptide binding]; other site 41431007603 IHF - DNA interface [nucleotide binding]; other site 41431007604 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 41431007605 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 41431007606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007607 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431007608 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007609 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007610 lipoyl synthase; Provisional; Region: PRK05481 41431007611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431007612 FeS/SAM binding site; other site 41431007613 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431007614 YcfA-like protein; Region: YcfA; cl00752 41431007615 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431007616 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 41431007617 Cysteine-rich domain; Region: CCG; pfam02754 41431007618 Cysteine-rich domain; Region: CCG; pfam02754 41431007619 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007620 putative active site [active] 41431007621 Acylphosphatase; Region: Acylphosphatase; cl00551 41431007622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431007623 binding surface 41431007624 TPR motif; other site 41431007625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431007626 binding surface 41431007627 TPR motif; other site 41431007628 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 41431007629 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 41431007630 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 41431007631 hinge; other site 41431007632 active site 41431007633 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 41431007634 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 41431007635 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 41431007636 Protein of unknown function DUF262; Region: DUF262; cl14890 41431007637 Uncharacterized conserved protein [Function unknown]; Region: COG4938 41431007638 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431007639 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 41431007640 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 41431007641 Protein of unknown function DUF45; Region: DUF45; cl00636 41431007642 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 41431007643 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 41431007644 putative active site [active] 41431007645 putative NTP binding site [chemical binding]; other site 41431007646 putative nucleic acid binding site [nucleotide binding]; other site 41431007647 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 41431007648 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431007649 active site 41431007650 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 41431007651 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 41431007652 putative active site [active] 41431007653 putative NTP binding site [chemical binding]; other site 41431007654 putative nucleic acid binding site [nucleotide binding]; other site 41431007655 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 41431007656 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431007657 active site 41431007658 Protein of unknown function DUF86; Region: DUF86; cl01031 41431007659 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431007660 active site 41431007661 NTP binding site [chemical binding]; other site 41431007662 metal binding triad [ion binding]; metal-binding site 41431007663 antibiotic binding site [chemical binding]; other site 41431007664 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 41431007665 Fic/DOC family; Region: Fic; cl00960 41431007666 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 41431007667 Protein of unknown function DUF86; Region: DUF86; cl01031 41431007668 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431007669 active site 41431007670 NTP binding site [chemical binding]; other site 41431007671 metal binding triad [ion binding]; metal-binding site 41431007672 antibiotic binding site [chemical binding]; other site 41431007673 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 41431007674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 41431007675 Helix-turn-helix domains; Region: HTH; cl00088 41431007676 Transposase; Region: DDE_Tnp_ISL3; pfam01610 41431007677 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431007678 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 41431007679 Integrase core domain; Region: rve; cl01316 41431007680 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 41431007681 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431007682 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 41431007683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431007684 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 41431007685 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431007686 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431007687 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 41431007688 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 41431007689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431007690 ATP binding site [chemical binding]; other site 41431007691 putative Mg++ binding site [ion binding]; other site 41431007692 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431007693 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 41431007694 Integrase core domain; Region: rve; cl01316 41431007695 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 41431007696 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 41431007697 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431007698 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 41431007699 substrate binding site [chemical binding]; other site 41431007700 active site 41431007701 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 41431007702 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 41431007703 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 41431007704 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 41431007705 DctM-like transporters; Region: DctM; pfam06808 41431007706 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 41431007707 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 41431007708 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431007709 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 41431007710 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 41431007711 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 41431007712 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 41431007713 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 41431007714 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 41431007715 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 41431007716 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 41431007717 active site 41431007718 Uncharacterized conserved protein [Function unknown]; Region: COG4997 41431007719 ornithine carbamoyltransferase; Provisional; Region: PRK00779 41431007720 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 41431007721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007722 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 41431007723 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431007724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431007725 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431007726 Probable transposase; Region: OrfB_IS605; pfam01385 41431007727 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431007728 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 41431007729 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 41431007730 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 41431007731 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 41431007732 H+ Antiporter protein; Region: 2A0121; TIGR00900 41431007733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431007734 putative substrate translocation pore; other site 41431007735 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007736 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 41431007737 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 41431007738 active site 41431007739 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 41431007740 Acyl transferase domain; Region: Acyl_transf_1; cl08282 41431007741 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007742 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 41431007743 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 41431007744 active site 41431007745 Acyl transferase domain; Region: Acyl_transf_1; cl08282 41431007746 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 41431007747 putative NADP binding site [chemical binding]; other site 41431007748 active site 41431007749 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007750 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 41431007751 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 41431007752 active site 41431007753 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 41431007754 Acyl transferase domain; Region: Acyl_transf_1; cl08282 41431007755 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 41431007756 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007757 Condensation domain; Region: Condensation; pfam00668 41431007758 Nonribosomal peptide synthase; Region: NRPS; pfam08415 41431007759 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431007760 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 41431007761 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007762 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 41431007763 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 41431007764 active site 41431007765 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 41431007766 Acyl transferase domain; Region: Acyl_transf_1; cl08282 41431007767 peptide synthase; Validated; Region: PRK05691 41431007768 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007769 peptide synthase; Provisional; Region: PRK12467 41431007770 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431007771 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007772 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 41431007773 peptide synthase; Provisional; Region: PRK12467 41431007774 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431007775 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007776 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431007777 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007778 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 41431007779 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 41431007780 peptide synthase; Provisional; Region: PRK12316 41431007781 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431007782 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007783 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 41431007784 peptide synthase; Provisional; Region: PRK12316 41431007785 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431007786 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007787 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 41431007788 Condensation domain; Region: Condensation; pfam00668 41431007789 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431007790 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 41431007791 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431007792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007793 NAD synthetase; Provisional; Region: PRK13981 41431007794 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 41431007795 multimer interface [polypeptide binding]; other site 41431007796 active site 41431007797 catalytic triad [active] 41431007798 protein interface 1 [polypeptide binding]; other site 41431007799 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 41431007800 homodimer interface [polypeptide binding]; other site 41431007801 NAD binding pocket [chemical binding]; other site 41431007802 ATP binding pocket [chemical binding]; other site 41431007803 Mg binding site [ion binding]; other site 41431007804 active-site loop [active] 41431007805 Gram-negative bacterial tonB protein; Region: TonB; cl10048 41431007806 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 41431007807 MORN repeat; Region: MORN; cl14787 41431007808 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 41431007809 MORN repeat; Region: MORN; cl14787 41431007810 MORN repeat; Region: MORN; cl14787 41431007811 MORN repeat; Region: MORN; cl14787 41431007812 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 41431007813 ABC-ATPase subunit interface; other site 41431007814 dimer interface [polypeptide binding]; other site 41431007815 putative PBP binding regions; other site 41431007816 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 41431007817 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 41431007818 ABC-ATPase subunit interface; other site 41431007819 dimer interface [polypeptide binding]; other site 41431007820 putative PBP binding regions; other site 41431007821 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 41431007822 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 41431007823 Walker A/P-loop; other site 41431007824 ATP binding site [chemical binding]; other site 41431007825 Q-loop/lid; other site 41431007826 ABC transporter signature motif; other site 41431007827 Walker B; other site 41431007828 D-loop; other site 41431007829 H-loop/switch region; other site 41431007830 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 41431007831 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 41431007832 siderophore binding site; other site 41431007833 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 41431007834 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 41431007835 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 41431007836 N-terminal plug; other site 41431007837 ligand-binding site [chemical binding]; other site 41431007838 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 41431007839 Protein of unknown function DUF82; Region: DUF82; pfam01927 41431007840 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 41431007841 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 41431007842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007843 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431007844 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 41431007845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007846 NAD(P) binding site [chemical binding]; other site 41431007847 active site 41431007848 glyoxylate reductase; Reviewed; Region: PRK13243 41431007849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007850 GAF domain; Region: GAF; cl00853 41431007851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431007852 phosphorylation site [posttranslational modification] 41431007853 dimer interface [polypeptide binding]; other site 41431007854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431007855 ATP binding site [chemical binding]; other site 41431007856 Mg2+ binding site [ion binding]; other site 41431007857 G-X-G motif; other site 41431007858 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 41431007859 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 41431007860 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905 41431007861 putative active site [active] 41431007862 Zn binding site [ion binding]; other site 41431007863 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 41431007864 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 41431007865 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 41431007866 minor groove reading motif; other site 41431007867 helix-hairpin-helix signature motif; other site 41431007868 substrate binding pocket [chemical binding]; other site 41431007869 active site 41431007870 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 41431007871 active site 41431007872 8-oxo-dGMP binding site [chemical binding]; other site 41431007873 nudix motif; other site 41431007874 metal binding site [ion binding]; metal-binding site 41431007875 Protein of unknown function (DUF760); Region: DUF760; pfam05542 41431007876 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 41431007877 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 41431007878 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431007879 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431007880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431007881 DNA binding residues [nucleotide binding] 41431007882 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431007883 putative acyl-acceptor binding pocket; other site 41431007884 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 41431007885 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 41431007886 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 41431007887 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431007888 Bacterial SH3 domain; Region: SH3_3; cl02551 41431007889 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 41431007890 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 41431007891 active site 41431007892 metal binding site [ion binding]; metal-binding site 41431007893 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 41431007894 Photosystem II protein; Region: PSII; cl08223 41431007895 Photosystem II reaction centre T protein; Region: PsbT; cl11601 41431007896 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 41431007897 ATP cone domain; Region: ATP-cone; pfam03477 41431007898 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 41431007899 RNA binding site [nucleotide binding]; other site 41431007900 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 41431007901 RNA binding site [nucleotide binding]; other site 41431007902 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 41431007903 RNA binding site [nucleotide binding]; other site 41431007904 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431007905 Phycobilisome protein; Region: Phycobilisome; cl08227 41431007906 Phycobilisome protein; Region: Phycobilisome; cl08227 41431007907 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431007908 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 41431007909 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431007910 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 41431007911 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 41431007912 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431007913 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 41431007914 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 41431007915 FO synthase subunit 2; Reviewed; Region: PRK07360 41431007916 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 41431007917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431007918 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 41431007919 Protein of unknown function (DUF990); Region: DUF990; cl01496 41431007920 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 41431007921 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 41431007922 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 41431007923 active site 41431007924 catalytic site [active] 41431007925 Domain of unknown function DUF20; Region: UPF0118; cl00465 41431007926 Protein of unknown function (DUF497); Region: DUF497; cl01108 41431007927 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 41431007928 BtpA family; Region: BtpA; cl00440 41431007929 GTP-binding protein YchF; Reviewed; Region: PRK09601 41431007930 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 41431007931 G1 box; other site 41431007932 GTP/Mg2+ binding site [chemical binding]; other site 41431007933 Switch I region; other site 41431007934 G2 box; other site 41431007935 Switch II region; other site 41431007936 G3 box; other site 41431007937 G4 box; other site 41431007938 G5 box; other site 41431007939 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 41431007940 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431007941 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 41431007942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431007943 Coenzyme A binding pocket [chemical binding]; other site 41431007944 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 41431007945 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 41431007946 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 41431007947 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431007948 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 41431007949 active site 41431007950 metal binding site [ion binding]; metal-binding site 41431007951 Protein of unknown function (DUF2396); Region: DUF2396; cl09868 41431007952 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 41431007953 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 41431007954 trimer interface [polypeptide binding]; other site 41431007955 putative metal binding site [ion binding]; other site 41431007956 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 41431007957 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 41431007958 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 41431007959 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 41431007960 Cation efflux family; Region: Cation_efflux; cl00316 41431007961 Lipoxygenase; Region: Lipoxygenase; pfam00305 41431007962 cytokinin trans-hydroxylase; Region: PLN02290 41431007963 Cytochrome P450; Region: p450; cl12078 41431007964 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 41431007965 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 41431007966 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 41431007967 DNA polymerase I; Provisional; Region: PRK05755 41431007968 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 41431007969 active site 41431007970 metal binding site 1 [ion binding]; metal-binding site 41431007971 putative 5' ssDNA interaction site; other site 41431007972 metal binding site 3; metal-binding site 41431007973 metal binding site 2 [ion binding]; metal-binding site 41431007974 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 41431007975 putative DNA binding site [nucleotide binding]; other site 41431007976 putative metal binding site [ion binding]; other site 41431007977 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 41431007978 active site 41431007979 catalytic site [active] 41431007980 substrate binding site [chemical binding]; other site 41431007981 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 41431007982 active site 41431007983 DNA binding site [nucleotide binding] 41431007984 catalytic site [active] 41431007985 exonuclease SbcC; Region: sbcc; TIGR00618 41431007986 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431007987 Walker A/P-loop; other site 41431007988 ATP binding site [chemical binding]; other site 41431007989 Q-loop/lid; other site 41431007990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431007991 ABC transporter signature motif; other site 41431007992 Walker B; other site 41431007993 D-loop; other site 41431007994 H-loop/switch region; other site 41431007995 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 41431007996 nucleotide binding site/active site [active] 41431007997 HIT family signature motif; other site 41431007998 catalytic residue [active] 41431007999 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 41431008000 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 41431008001 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 41431008002 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 41431008003 Walker A/P-loop; other site 41431008004 ATP binding site [chemical binding]; other site 41431008005 Q-loop/lid; other site 41431008006 ABC transporter signature motif; other site 41431008007 Walker B; other site 41431008008 D-loop; other site 41431008009 H-loop/switch region; other site 41431008010 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 41431008011 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 41431008012 Domain of unknown function DUF143; Region: DUF143; cl00519 41431008013 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 41431008014 L-asparaginase II; Region: Asparaginase_II; cl01842 41431008015 Dehydratase family; Region: ILVD_EDD; cl00340 41431008016 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 41431008017 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 41431008018 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 41431008019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008020 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 41431008021 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 41431008022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431008023 DRTGG domain; Region: DRTGG; cl12147 41431008024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 41431008025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431008026 dimerization interface [polypeptide binding]; other site 41431008027 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 41431008028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431008029 dimer interface [polypeptide binding]; other site 41431008030 phosphorylation site [posttranslational modification] 41431008031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431008032 ATP binding site [chemical binding]; other site 41431008033 Mg2+ binding site [ion binding]; other site 41431008034 G-X-G motif; other site 41431008035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431008036 Major Facilitator Superfamily; Region: MFS_1; pfam07690 41431008037 putative substrate translocation pore; other site 41431008038 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008039 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008040 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008041 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008042 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008043 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 41431008044 GUN4-like; Region: GUN4; pfam05419 41431008045 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 41431008046 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 41431008047 active site 41431008048 catalytic tetrad [active] 41431008049 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008050 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008051 secreted effector protein PipB2; Provisional; Region: PRK15196 41431008052 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008053 Ferritin-like; Region: Ferritin-like; pfam12902 41431008054 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 41431008055 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 41431008056 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 41431008057 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 41431008058 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 41431008059 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 41431008060 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 41431008061 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 41431008062 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 41431008063 potential catalytic triad [active] 41431008064 conserved cys residue [active] 41431008065 Major royal jelly protein; Region: MRJP; pfam03022 41431008066 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 41431008067 Domain interface; other site 41431008068 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 41431008069 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 41431008070 Phd_YefM; Region: PhdYeFM; cl09153 41431008071 Helix-turn-helix domains; Region: HTH; cl00088 41431008072 putative DNA binding site [nucleotide binding]; other site 41431008073 putative Zn2+ binding site [ion binding]; other site 41431008074 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 41431008075 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 41431008076 putative ligand binding site [chemical binding]; other site 41431008077 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474 41431008078 Predicted RNA interaction site [nucleotide binding]; other site 41431008079 putative binding site; other site 41431008080 Mutations affecting start-site selection; other site 41431008081 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 41431008082 oxyanion hole [active] 41431008083 Low molecular weight phosphatase family; Region: LMWPc; cd00115 41431008084 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 41431008085 active site 41431008086 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008087 putative active site [active] 41431008088 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431008089 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 41431008090 GUN4-like; Region: GUN4; pfam05419 41431008091 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 41431008092 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 41431008093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008095 TPR motif; other site 41431008096 binding surface 41431008097 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 41431008098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008099 binding surface 41431008100 TPR motif; other site 41431008101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008102 binding surface 41431008103 TPR motif; other site 41431008104 conserved hypothetical protein; Region: MJ1255; TIGR00661 41431008105 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431008106 H-loop/switch region; other site 41431008107 AIR carboxylase; Region: AIRC; cl00310 41431008108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008109 binding surface 41431008110 TPR motif; other site 41431008111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008112 binding surface 41431008113 TPR motif; other site 41431008114 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 41431008115 active site 41431008116 zinc binding site [ion binding]; other site 41431008117 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 41431008118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008119 NAD(P) binding site [chemical binding]; other site 41431008120 active site 41431008121 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 41431008122 catalytic center binding site [active] 41431008123 ATP binding site [chemical binding]; other site 41431008124 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 41431008125 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 41431008126 DXD motif; other site 41431008127 PilZ domain; Region: PilZ; cl01260 41431008128 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 41431008129 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 41431008130 putative dimer interface [polypeptide binding]; other site 41431008131 putative anticodon binding site; other site 41431008132 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 41431008133 homodimer interface [polypeptide binding]; other site 41431008134 motif 1; other site 41431008135 motif 2; other site 41431008136 active site 41431008137 motif 3; other site 41431008138 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 41431008139 homotrimer interaction site [polypeptide binding]; other site 41431008140 zinc binding site [ion binding]; other site 41431008141 CDP-binding sites; other site 41431008142 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 41431008143 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 41431008144 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 41431008145 Walker A/P-loop; other site 41431008146 ATP binding site [chemical binding]; other site 41431008147 Q-loop/lid; other site 41431008148 ABC transporter signature motif; other site 41431008149 Walker B; other site 41431008150 D-loop; other site 41431008151 H-loop/switch region; other site 41431008152 phage shock protein A; Region: phageshock_pspA; TIGR02977 41431008153 TIGR03440 family protein; Region: unchr_TIGR03440 41431008154 DinB superfamily; Region: DinB_2; cl00986 41431008155 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 41431008156 TIGR03442 family protein; Region: TIGR03442 41431008157 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 41431008158 putative active site [active] 41431008159 putative dimer interface [polypeptide binding]; other site 41431008160 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 41431008161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431008162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431008163 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431008164 Probable transposase; Region: OrfB_IS605; pfam01385 41431008165 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431008166 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431008167 seryl-tRNA synthetase; Provisional; Region: PRK05431 41431008168 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 41431008169 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 41431008170 dimer interface [polypeptide binding]; other site 41431008171 active site 41431008172 motif 1; other site 41431008173 motif 2; other site 41431008174 motif 3; other site 41431008175 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 41431008176 GTPase RsgA; Reviewed; Region: PRK12289 41431008177 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 41431008178 GTPase/OB domain interface [polypeptide binding]; other site 41431008179 GTPase/Zn-binding domain interface [polypeptide binding]; other site 41431008180 GTP/Mg2+ binding site [chemical binding]; other site 41431008181 G4 box; other site 41431008182 G5 box; other site 41431008183 G1 box; other site 41431008184 Switch I region; other site 41431008185 G2 box; other site 41431008186 G3 box; other site 41431008187 Switch II region; other site 41431008188 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 41431008189 CPxP motif; other site 41431008190 chaperone protein DnaJ; Provisional; Region: PRK14293 41431008191 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431008192 HSP70 interaction site [polypeptide binding]; other site 41431008193 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 41431008194 Zn binding sites [ion binding]; other site 41431008195 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 41431008196 dimer interface [polypeptide binding]; other site 41431008197 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431008198 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 41431008199 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 41431008200 photosystem II protein Psb27; Provisional; Region: PLN00064; cl11841 41431008201 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 41431008202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431008203 Walker A/P-loop; other site 41431008204 ATP binding site [chemical binding]; other site 41431008205 fumarate hydratase; Reviewed; Region: fumC; PRK00485 41431008206 Class II fumarases; Region: Fumarase_classII; cd01362 41431008207 active site 41431008208 tetramer interface [polypeptide binding]; other site 41431008209 PemK-like protein; Region: PemK; cl00995 41431008210 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431008211 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 41431008212 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 41431008213 putative ligand binding site [chemical binding]; other site 41431008214 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 41431008215 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 41431008216 dimer interface [polypeptide binding]; other site 41431008217 ssDNA binding site [nucleotide binding]; other site 41431008218 tetramer (dimer of dimers) interface [polypeptide binding]; other site 41431008219 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 41431008220 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 41431008221 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 41431008222 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 41431008223 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 41431008224 protein I interface; other site 41431008225 D2 interface; other site 41431008226 protein T interface; other site 41431008227 chlorophyll binding site; other site 41431008228 beta carotene binding site; other site 41431008229 pheophytin binding site; other site 41431008230 manganese-stabilizing polypeptide interface; other site 41431008231 CP43 interface; other site 41431008232 protein L interface; other site 41431008233 oxygen evolving complex binding site; other site 41431008234 bromide binding site; other site 41431008235 quinone binding site; other site 41431008236 Fe binding site [ion binding]; other site 41431008237 core light harvesting interface; other site 41431008238 cytochrome b559 alpha subunit interface; other site 41431008239 cytochrome c-550 interface; other site 41431008240 protein J interface; other site 41431008241 V-type ATP synthase subunit A; Provisional; Region: PRK04192 41431008242 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 41431008243 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 41431008244 Walker A motif/ATP binding site; other site 41431008245 Walker B motif; other site 41431008246 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 41431008247 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431008248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431008249 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431008250 Probable transposase; Region: OrfB_IS605; pfam01385 41431008251 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431008252 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 41431008253 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 41431008254 ATP synthase subunit C; Region: ATP-synt_C; cl00466 41431008255 V-type ATP synthase subunit I; Validated; Region: PRK05771 41431008256 ATP synthase subunit D; Region: ATP-synt_D; cl00613 41431008257 V-type ATP synthase subunit B; Provisional; Region: PRK02118 41431008258 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 41431008259 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 41431008260 Walker A motif homologous position; other site 41431008261 Walker B motif; other site 41431008262 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431008263 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 41431008264 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431008265 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 41431008266 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 41431008267 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431008268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008269 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 41431008270 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431008271 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 41431008272 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431008273 T5orf172 domain; Region: T5orf172; cl11176 41431008274 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 41431008275 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 41431008276 HIGH motif; other site 41431008277 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 41431008278 active site 41431008279 KMSKS motif; other site 41431008280 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 41431008281 tRNA binding surface [nucleotide binding]; other site 41431008282 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431008283 YcfA-like protein; Region: YcfA; cl00752 41431008284 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431008285 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431008286 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 41431008287 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 41431008288 dimer interface [polypeptide binding]; other site 41431008289 active site 41431008290 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 41431008291 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431008292 HSP70 interaction site [polypeptide binding]; other site 41431008293 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; cl14104 41431008294 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431008295 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 41431008296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431008297 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431008298 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431008299 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431008300 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431008301 active site 41431008302 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431008303 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431008304 phosphoenolpyruvate synthase; Validated; Region: PRK06464 41431008305 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 41431008306 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 41431008307 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 41431008308 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008309 putative active site [active] 41431008310 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 41431008311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 41431008312 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 41431008313 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 41431008314 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431008315 GAF domain; Region: GAF; cl00853 41431008316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431008317 metal binding site [ion binding]; metal-binding site 41431008318 active site 41431008319 I-site; other site 41431008320 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431008321 ligand binding site [chemical binding]; other site 41431008322 flexible hinge region; other site 41431008323 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 41431008324 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 41431008325 putative active site [active] 41431008326 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 41431008327 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 41431008328 Walker A/P-loop; other site 41431008329 ATP binding site [chemical binding]; other site 41431008330 Q-loop/lid; other site 41431008331 ABC transporter signature motif; other site 41431008332 Walker B; other site 41431008333 D-loop; other site 41431008334 H-loop/switch region; other site 41431008335 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 41431008336 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 41431008337 E3 interaction surface; other site 41431008338 lipoyl attachment site [posttranslational modification]; other site 41431008339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008340 binding surface 41431008341 TPR motif; other site 41431008342 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 41431008343 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 41431008344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008345 binding surface 41431008346 TPR motif; other site 41431008347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008348 binding surface 41431008349 TPR motif; other site 41431008350 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 41431008351 active site 41431008352 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 41431008353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008354 binding surface 41431008355 TPR motif; other site 41431008356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008357 binding surface 41431008358 TPR motif; other site 41431008359 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 41431008360 PPIC-type PPIASE domain; Region: Rotamase; cl08278 41431008361 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 41431008362 OstA-like protein; Region: OstA; cl00844 41431008363 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 41431008364 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 41431008365 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 41431008366 proposed catalytic triad [active] 41431008367 active site nucleophile [active] 41431008368 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 41431008369 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431008370 active site 41431008371 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 41431008372 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 41431008373 active site 41431008374 Nuclease-related domain; Region: NERD; pfam08378 41431008375 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 41431008376 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 41431008377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431008378 FeS/SAM binding site; other site 41431008379 TRAM domain; Region: TRAM; cl01282 41431008380 Protein kinase domain; Region: Pkinase; pfam00069 41431008381 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431008382 active site 41431008383 ATP binding site [chemical binding]; other site 41431008384 substrate binding site [chemical binding]; other site 41431008385 activation loop (A-loop); other site 41431008386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008387 TPR motif; other site 41431008388 binding surface 41431008389 phosphoglucomutase; Region: PLN02307 41431008390 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 41431008391 substrate binding site [chemical binding]; other site 41431008392 dimer interface [polypeptide binding]; other site 41431008393 active site 41431008394 metal binding site [ion binding]; metal-binding site 41431008395 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 41431008396 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 41431008397 Walker A/P-loop; other site 41431008398 ATP binding site [chemical binding]; other site 41431008399 Q-loop/lid; other site 41431008400 ABC transporter signature motif; other site 41431008401 Walker B; other site 41431008402 D-loop; other site 41431008403 H-loop/switch region; other site 41431008404 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 41431008405 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 41431008406 Walker A/P-loop; other site 41431008407 ATP binding site [chemical binding]; other site 41431008408 Q-loop/lid; other site 41431008409 ABC transporter signature motif; other site 41431008410 Walker B; other site 41431008411 D-loop; other site 41431008412 H-loop/switch region; other site 41431008413 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 41431008414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431008415 dimer interface [polypeptide binding]; other site 41431008416 conserved gate region; other site 41431008417 putative PBP binding loops; other site 41431008418 ABC-ATPase subunit interface; other site 41431008419 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 41431008420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431008421 dimer interface [polypeptide binding]; other site 41431008422 conserved gate region; other site 41431008423 putative PBP binding loops; other site 41431008424 ABC-ATPase subunit interface; other site 41431008425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 41431008426 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 41431008427 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 41431008428 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431008429 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431008430 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431008431 GAF domain; Region: GAF; cl00853 41431008432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431008433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431008434 dimer interface [polypeptide binding]; other site 41431008435 phosphorylation site [posttranslational modification] 41431008436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431008437 ATP binding site [chemical binding]; other site 41431008438 Mg2+ binding site [ion binding]; other site 41431008439 G-X-G motif; other site 41431008440 Response regulator receiver domain; Region: Response_reg; pfam00072 41431008441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008442 active site 41431008443 phosphorylation site [posttranslational modification] 41431008444 intermolecular recognition site; other site 41431008445 dimerization interface [polypeptide binding]; other site 41431008446 ribonuclease III; Reviewed; Region: rnc; PRK00102 41431008447 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 41431008448 dimerization interface [polypeptide binding]; other site 41431008449 active site 41431008450 metal binding site [ion binding]; metal-binding site 41431008451 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 41431008452 dsRNA binding site [nucleotide binding]; other site 41431008453 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 41431008454 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 41431008455 active site 41431008456 substrate binding site [chemical binding]; other site 41431008457 Mg2+ binding site [ion binding]; other site 41431008458 EamA-like transporter family; Region: EamA; cl01037 41431008459 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 41431008460 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 41431008461 substrate binding site [chemical binding]; other site 41431008462 SOUL heme-binding protein; Region: SOUL; pfam04832 41431008463 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 41431008464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431008465 Dienelactone hydrolase family; Region: DLH; pfam01738 41431008466 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431008467 putative acetyltransferase; Provisional; Region: PRK03624 41431008468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431008469 Coenzyme A binding pocket [chemical binding]; other site 41431008470 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 41431008471 Helix-turn-helix domains; Region: HTH; cl00088 41431008472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008473 Response regulator receiver domain; Region: Response_reg; pfam00072 41431008474 active site 41431008475 phosphorylation site [posttranslational modification] 41431008476 intermolecular recognition site; other site 41431008477 dimerization interface [polypeptide binding]; other site 41431008478 ParB-like nuclease domain; Region: ParBc; cl02129 41431008479 Helix-turn-helix domains; Region: HTH; cl00088 41431008480 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 41431008481 dimer interface [polypeptide binding]; other site 41431008482 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 41431008483 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 41431008484 dimerization interface [polypeptide binding]; other site 41431008485 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 41431008486 ATP binding site [chemical binding]; other site 41431008487 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 41431008488 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008489 putative active site [active] 41431008490 NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]; Region: CobT; COG2038 41431008491 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 41431008492 active site pocket [active] 41431008493 putative dimer interface [polypeptide binding]; other site 41431008494 putative cataytic base [active] 41431008495 S-layer homology domain; Region: SLH; pfam00395 41431008496 S-layer homology domain; Region: SLH; pfam00395 41431008497 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 41431008498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008499 NAD(P) binding site [chemical binding]; other site 41431008500 active site 41431008501 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 41431008502 FAD binding domain; Region: FAD_binding_4; pfam01565 41431008503 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 41431008504 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431008505 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 41431008506 Ligand binding site; other site 41431008507 Putative Catalytic site; other site 41431008508 DXD motif; other site 41431008509 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431008510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008511 NAD(P) binding site [chemical binding]; other site 41431008512 active site 41431008513 Cupin domain; Region: Cupin_2; cl09118 41431008514 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 41431008515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431008516 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 41431008517 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 41431008518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008519 NAD(P) binding site [chemical binding]; other site 41431008520 active site 41431008521 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 41431008522 substrate binding site; other site 41431008523 Response regulator receiver domain; Region: Response_reg; pfam00072 41431008524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008525 active site 41431008526 phosphorylation site [posttranslational modification] 41431008527 intermolecular recognition site; other site 41431008528 dimerization interface [polypeptide binding]; other site 41431008529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008530 Response regulator receiver domain; Region: Response_reg; pfam00072 41431008531 active site 41431008532 phosphorylation site [posttranslational modification] 41431008533 intermolecular recognition site; other site 41431008534 dimerization interface [polypeptide binding]; other site 41431008535 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431008536 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 41431008537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431008538 dimerization interface [polypeptide binding]; other site 41431008539 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431008540 GAF domain; Region: GAF; cl00853 41431008541 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431008542 GAF domain; Region: GAF; cl00853 41431008543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 41431008544 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431008545 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 41431008546 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 41431008547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431008548 dimerization interface [polypeptide binding]; other site 41431008549 GAF domain; Region: GAF; cl00853 41431008550 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431008551 GAF domain; Region: GAF; cl00853 41431008552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 41431008553 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431008554 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 41431008555 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431008556 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431008557 putative binding surface; other site 41431008558 active site 41431008559 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 41431008560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431008561 ATP binding site [chemical binding]; other site 41431008562 Mg2+ binding site [ion binding]; other site 41431008563 G-X-G motif; other site 41431008564 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431008565 Response regulator receiver domain; Region: Response_reg; pfam00072 41431008566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008567 active site 41431008568 phosphorylation site [posttranslational modification] 41431008569 intermolecular recognition site; other site 41431008570 dimerization interface [polypeptide binding]; other site 41431008571 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 41431008572 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 41431008573 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 41431008574 Septum formation topological specificity factor MinE; Region: MinE; cl00538 41431008575 septum site-determining protein MinD; Region: minD_bact; TIGR01968 41431008576 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 41431008577 Switch I; other site 41431008578 Switch II; other site 41431008579 septum formation inhibitor; Reviewed; Region: minC; PRK00513 41431008580 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 41431008581 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431008582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008583 active site 41431008584 phosphorylation site [posttranslational modification] 41431008585 intermolecular recognition site; other site 41431008586 dimerization interface [polypeptide binding]; other site 41431008587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431008588 DNA binding site [nucleotide binding] 41431008589 ATP phosphoribosyltransferase; Region: HisG; cl15266 41431008590 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 41431008591 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 41431008592 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431008593 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 41431008594 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 41431008595 Walker A/P-loop; other site 41431008596 ATP binding site [chemical binding]; other site 41431008597 Q-loop/lid; other site 41431008598 ABC transporter signature motif; other site 41431008599 Walker B; other site 41431008600 D-loop; other site 41431008601 H-loop/switch region; other site 41431008602 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 41431008603 putative carbohydrate binding site [chemical binding]; other site 41431008604 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431008605 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431008606 active site 41431008607 NTP binding site [chemical binding]; other site 41431008608 metal binding triad [ion binding]; metal-binding site 41431008609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431008610 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431008611 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431008612 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 41431008613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431008614 Coenzyme A binding pocket [chemical binding]; other site 41431008615 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431008616 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008617 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 41431008618 Bacterial sugar transferase; Region: Bac_transf; cl00939 41431008619 Domain of unknown function DUF20; Region: UPF0118; cl00465 41431008620 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 41431008621 ADP-glucose phosphorylase; Region: PLN02643 41431008622 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 41431008623 nucleotide binding site/active site [active] 41431008624 HIT family signature motif; other site 41431008625 catalytic residue [active] 41431008626 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008627 putative active site [active] 41431008628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008629 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 41431008630 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431008631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008632 active site 41431008633 phosphorylation site [posttranslational modification] 41431008634 intermolecular recognition site; other site 41431008635 dimerization interface [polypeptide binding]; other site 41431008636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431008637 DNA binding site [nucleotide binding] 41431008638 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 41431008639 putative GSH binding site [chemical binding]; other site 41431008640 catalytic residues [active] 41431008641 BolA-like protein; Region: BolA; cl00386 41431008642 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008643 putative active site [active] 41431008644 RFC reduced folate carrier; Region: rfc; TIGR00806 41431008645 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 41431008646 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431008647 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 41431008648 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 41431008649 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431008650 putative glycosyl transferase; Provisional; Region: PRK10307 41431008651 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 41431008652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008653 binding surface 41431008654 TPR motif; other site 41431008655 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 41431008656 homodimer interface [polypeptide binding]; other site 41431008657 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 41431008658 active site pocket [active] 41431008659 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 41431008660 Rhomboid family; Region: Rhomboid; cl11446 41431008661 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008662 putative active site [active] 41431008663 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 41431008664 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 41431008665 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431008666 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 41431008667 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 41431008668 UGMP family protein; Validated; Region: PRK09604 41431008669 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 41431008670 probable methyltransferase; Region: TIGR03438 41431008671 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 41431008672 Helix-turn-helix domains; Region: HTH; cl00088 41431008673 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 41431008674 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 41431008675 putative dimerization interface [polypeptide binding]; other site 41431008676 CHAT domain; Region: CHAT; cl02083 41431008677 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431008678 phosphopeptide binding site; other site 41431008679 Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401 41431008680 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 41431008681 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 41431008682 Walker A/P-loop; other site 41431008683 ATP binding site [chemical binding]; other site 41431008684 Q-loop/lid; other site 41431008685 ABC transporter signature motif; other site 41431008686 Walker B; other site 41431008687 D-loop; other site 41431008688 H-loop/switch region; other site 41431008689 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 41431008690 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 41431008691 dimer interface [polypeptide binding]; other site 41431008692 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 41431008693 active site 41431008694 Fe binding site [ion binding]; other site 41431008695 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 41431008696 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 41431008697 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 41431008698 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008699 putative active site [active] 41431008700 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 41431008701 Chain length determinant protein; Region: Wzz; cl01623 41431008702 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431008703 Esterase/lipase [General function prediction only]; Region: COG1647 41431008704 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 41431008705 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 41431008706 nucleotide binding pocket [chemical binding]; other site 41431008707 K-X-D-G motif; other site 41431008708 catalytic site [active] 41431008709 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 41431008710 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 41431008711 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 41431008712 Dimer interface [polypeptide binding]; other site 41431008713 secreted effector protein PipB2; Provisional; Region: PRK15196 41431008714 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008715 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431008716 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008717 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008718 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008719 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008720 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008721 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008722 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 41431008723 substrate binding site [chemical binding]; other site 41431008724 peptide chain release factor 2; Validated; Region: prfB; PRK00578 41431008725 RF-1 domain; Region: RF-1; cl02875 41431008726 RF-1 domain; Region: RF-1; cl02875 41431008727 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 41431008728 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 41431008729 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 41431008730 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 41431008731 dimer interface [polypeptide binding]; other site 41431008732 motif 1; other site 41431008733 active site 41431008734 motif 2; other site 41431008735 motif 3; other site 41431008736 Predicted acetyltransferase [General function prediction only]; Region: COG3393 41431008737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431008738 Coenzyme A binding pocket [chemical binding]; other site 41431008739 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 41431008740 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 41431008741 Uncharacterized conserved protein [Function unknown]; Region: COG3349 41431008742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008743 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 41431008744 putative hydrophobic ligand binding site [chemical binding]; other site 41431008745 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 41431008746 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 41431008747 thiamine phosphate binding site [chemical binding]; other site 41431008748 active site 41431008749 pyrophosphate binding site [ion binding]; other site 41431008750 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 41431008751 thiS-thiF/thiG interaction site; other site 41431008752 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 41431008753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431008754 S-adenosylmethionine binding site [chemical binding]; other site 41431008755 Double zinc ribbon; Region: DZR; pfam12773 41431008756 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 41431008757 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 41431008758 Cl- selectivity filter; other site 41431008759 Cl- binding residues [ion binding]; other site 41431008760 pore gating glutamate residue; other site 41431008761 dimer interface [polypeptide binding]; other site 41431008762 H+/Cl- coupling transport residue; other site 41431008763 FOG: CBS domain [General function prediction only]; Region: COG0517 41431008764 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 41431008765 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 41431008766 Ligand Binding Site [chemical binding]; other site 41431008767 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 41431008768 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 41431008769 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 41431008770 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 41431008771 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 41431008772 dimerization interface [polypeptide binding]; other site 41431008773 active site 41431008774 haemagglutination activity domain; Region: Haemagg_act; cl05436 41431008775 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 41431008776 Surface antigen; Region: Bac_surface_Ag; cl03097 41431008777 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431008778 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431008779 Cache domain; Region: Cache_1; pfam02743 41431008780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431008781 dimerization interface [polypeptide binding]; other site 41431008782 PAS domain S-box; Region: sensory_box; TIGR00229 41431008783 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431008784 putative active site [active] 41431008785 heme pocket [chemical binding]; other site 41431008786 Glutaminase; Region: Glutaminase; cl00907 41431008787 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 41431008788 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431008789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431008790 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 41431008791 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 41431008792 NeuB family; Region: NeuB; cl00496 41431008793 SAF domain; Region: SAF; cl00555 41431008794 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 41431008795 Metal-binding active site; metal-binding site 41431008796 AP (apurinic/apyrimidinic) site pocket; other site 41431008797 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431008798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008799 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 41431008800 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431008801 cofactor binding site; other site 41431008802 DNA binding site [nucleotide binding] 41431008803 substrate interaction site [chemical binding]; other site 41431008804 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 41431008805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431008806 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 41431008807 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 41431008808 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 41431008809 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431008810 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431008811 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 41431008812 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 41431008813 PAS domain S-box; Region: sensory_box; TIGR00229 41431008814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431008815 putative active site [active] 41431008816 heme pocket [chemical binding]; other site 41431008817 PAS domain S-box; Region: sensory_box; TIGR00229 41431008818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431008819 putative active site [active] 41431008820 heme pocket [chemical binding]; other site 41431008821 PAS fold; Region: PAS_4; pfam08448 41431008822 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431008823 GAF domain; Region: GAF; cl00853 41431008824 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 41431008825 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431008826 putative active site [active] 41431008827 heme pocket [chemical binding]; other site 41431008828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431008829 dimer interface [polypeptide binding]; other site 41431008830 phosphorylation site [posttranslational modification] 41431008831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431008832 ATP binding site [chemical binding]; other site 41431008833 Mg2+ binding site [ion binding]; other site 41431008834 G-X-G motif; other site 41431008835 Response regulator receiver domain; Region: Response_reg; pfam00072 41431008836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008837 active site 41431008838 phosphorylation site [posttranslational modification] 41431008839 intermolecular recognition site; other site 41431008840 dimerization interface [polypeptide binding]; other site 41431008841 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 41431008842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431008843 dimer interface [polypeptide binding]; other site 41431008844 phosphorylation site [posttranslational modification] 41431008845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431008846 ATP binding site [chemical binding]; other site 41431008847 Mg2+ binding site [ion binding]; other site 41431008848 G-X-G motif; other site 41431008849 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431008850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008851 active site 41431008852 phosphorylation site [posttranslational modification] 41431008853 intermolecular recognition site; other site 41431008854 dimerization interface [polypeptide binding]; other site 41431008855 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431008856 DNA binding site [nucleotide binding] 41431008857 Creatinine amidohydrolase; Region: Creatininase; cl00618 41431008858 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 41431008859 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431008860 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 41431008861 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 41431008862 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 41431008863 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431008864 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 41431008865 active site 41431008866 metal binding site [ion binding]; metal-binding site 41431008867 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 41431008868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431008869 binding surface 41431008870 TPR motif; other site 41431008871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 41431008872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 41431008873 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 41431008874 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431008875 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431008876 active site 41431008877 ATP binding site [chemical binding]; other site 41431008878 substrate binding site [chemical binding]; other site 41431008879 activation loop (A-loop); other site 41431008880 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 41431008881 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 41431008882 putative ligand binding site [chemical binding]; other site 41431008883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431008884 S-adenosylmethionine binding site [chemical binding]; other site 41431008885 phosphate acetyltransferase; Reviewed; Region: PRK05632 41431008886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431008887 DRTGG domain; Region: DRTGG; cl12147 41431008888 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 41431008889 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 41431008890 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 41431008891 Protein of unknown function DUF262; Region: DUF262; cl14890 41431008892 Protein of unknown function DUF262; Region: DUF262; cl14890 41431008893 Protein of unknown function DUF262; Region: DUF262; cl14890 41431008894 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 41431008895 trimer interface [polypeptide binding]; other site 41431008896 dimer interface [polypeptide binding]; other site 41431008897 putative active site [active] 41431008898 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 41431008899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008901 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 41431008902 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 41431008903 homodimer interface [polypeptide binding]; other site 41431008904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431008905 catalytic residue [active] 41431008906 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 41431008907 active site 41431008908 ribulose/triose binding site [chemical binding]; other site 41431008909 phosphate binding site [ion binding]; other site 41431008910 substrate (anthranilate) binding pocket [chemical binding]; other site 41431008911 product (indole) binding pocket [chemical binding]; other site 41431008912 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 41431008913 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 41431008914 catalytic triad [active] 41431008915 Peptidase family M48; Region: Peptidase_M48; cl12018 41431008916 Helix-turn-helix domains; Region: HTH; cl00088 41431008917 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 41431008918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008919 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 41431008920 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 41431008921 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 41431008922 Fatty acid desaturase; Region: FA_desaturase; pfam00487 41431008923 putative di-iron ligands [ion binding]; other site 41431008924 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 41431008925 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 41431008926 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 41431008927 dimerization interface [polypeptide binding]; other site 41431008928 putative ATP binding site [chemical binding]; other site 41431008929 phosphodiesterase; Provisional; Region: PRK12704 41431008930 Hemagglutinin; Region: Hemagglutinin; pfam00509 41431008931 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 41431008932 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 41431008933 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431008934 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 41431008935 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431008936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431008937 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 41431008938 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 41431008939 metal ion-dependent adhesion site (MIDAS); other site 41431008940 Protein of unknown function DUF262; Region: DUF262; cl14890 41431008941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 41431008942 Helix-turn-helix domains; Region: HTH; cl00088 41431008943 Transposase; Region: DDE_Tnp_ISL3; pfam01610 41431008944 Cupin domain; Region: Cupin_2; cl09118 41431008945 acetyl-CoA synthetase; Provisional; Region: PRK00174 41431008946 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 41431008947 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431008948 YcfA-like protein; Region: YcfA; cl00752 41431008949 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431008950 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 41431008951 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 41431008952 Walker A/P-loop; other site 41431008953 ATP binding site [chemical binding]; other site 41431008954 Q-loop/lid; other site 41431008955 ABC transporter signature motif; other site 41431008956 Walker B; other site 41431008957 D-loop; other site 41431008958 H-loop/switch region; other site 41431008959 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 41431008960 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 41431008961 Walker A/P-loop; other site 41431008962 ATP binding site [chemical binding]; other site 41431008963 Q-loop/lid; other site 41431008964 ABC transporter signature motif; other site 41431008965 Walker B; other site 41431008966 D-loop; other site 41431008967 H-loop/switch region; other site 41431008968 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431008969 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 41431008970 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 41431008971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 41431008972 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431008973 Response regulator receiver domain; Region: Response_reg; pfam00072 41431008974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008975 active site 41431008976 phosphorylation site [posttranslational modification] 41431008977 intermolecular recognition site; other site 41431008978 dimerization interface [polypeptide binding]; other site 41431008979 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431008980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008981 active site 41431008982 phosphorylation site [posttranslational modification] 41431008983 intermolecular recognition site; other site 41431008984 dimerization interface [polypeptide binding]; other site 41431008985 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431008986 DNA binding site [nucleotide binding] 41431008987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431008988 dimerization interface [polypeptide binding]; other site 41431008989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431008990 dimer interface [polypeptide binding]; other site 41431008991 phosphorylation site [posttranslational modification] 41431008992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431008993 ATP binding site [chemical binding]; other site 41431008994 Mg2+ binding site [ion binding]; other site 41431008995 G-X-G motif; other site 41431008996 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 41431008997 intersubunit interface [polypeptide binding]; other site 41431008998 active site 41431008999 catalytic residue [active] 41431009000 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 41431009001 Recombination protein O N terminal; Region: RecO_N; pfam11967 41431009002 Recombination protein O C terminal; Region: RecO_C; pfam02565 41431009003 H+ Antiporter protein; Region: 2A0121; TIGR00900 41431009004 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 41431009005 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 41431009006 adenylosuccinate lyase; Provisional; Region: PRK07380 41431009007 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 41431009008 tetramer interface [polypeptide binding]; other site 41431009009 active site 41431009010 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 41431009011 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 41431009012 oligomer interface [polypeptide binding]; other site 41431009013 active site residues [active] 41431009014 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 41431009015 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431009016 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 41431009017 interchain domain interface [polypeptide binding]; other site 41431009018 intrachain domain interface; other site 41431009019 Qi binding site; other site 41431009020 Qo binding site; other site 41431009021 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 41431009022 Qi binding site; other site 41431009023 intrachain domain interface; other site 41431009024 interchain domain interface [polypeptide binding]; other site 41431009025 heme bH binding site [chemical binding]; other site 41431009026 heme bL binding site [chemical binding]; other site 41431009027 Qo binding site; other site 41431009028 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 41431009029 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 41431009030 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 41431009031 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 41431009032 Cupin domain; Region: Cupin_2; cl09118 41431009033 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 41431009034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431009035 S-adenosylmethionine binding site [chemical binding]; other site 41431009036 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 41431009037 Late competence development protein ComFB; Region: ComFB; pfam10719 41431009038 prolyl-tRNA synthetase; Provisional; Region: PRK09194 41431009039 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 41431009040 dimer interface [polypeptide binding]; other site 41431009041 motif 1; other site 41431009042 active site 41431009043 motif 2; other site 41431009044 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 41431009045 putative deacylase active site [active] 41431009046 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 41431009047 active site 41431009048 motif 3; other site 41431009049 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 41431009050 anticodon binding site; other site 41431009051 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431009052 glycine dehydrogenase; Provisional; Region: PRK05367 41431009053 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 41431009054 tetramer interface [polypeptide binding]; other site 41431009055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431009056 catalytic residue [active] 41431009057 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 41431009058 tetramer interface [polypeptide binding]; other site 41431009059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431009060 catalytic residue [active] 41431009061 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431009062 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431009063 Helix-turn-helix domains; Region: HTH; cl00088 41431009064 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 41431009065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431009066 Walker A/P-loop; other site 41431009067 ATP binding site [chemical binding]; other site 41431009068 Q-loop/lid; other site 41431009069 ABC transporter signature motif; other site 41431009070 Walker B; other site 41431009071 D-loop; other site 41431009072 H-loop/switch region; other site 41431009073 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431009074 Cupin domain; Region: Cupin_2; cl09118 41431009075 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 41431009076 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431009077 active site 41431009078 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 41431009079 putative ADP-binding pocket [chemical binding]; other site 41431009080 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431009081 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 41431009082 active site 41431009083 lipoyl synthase; Provisional; Region: PRK12928 41431009084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431009085 FeS/SAM binding site; other site 41431009086 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 41431009087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431009088 Walker A motif; other site 41431009089 ATP binding site [chemical binding]; other site 41431009090 Walker B motif; other site 41431009091 arginine finger; other site 41431009092 Peptidase family M41; Region: Peptidase_M41; pfam01434 41431009093 S-layer homology domain; Region: SLH; pfam00395 41431009094 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431009095 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 41431009096 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 41431009097 Psb28 protein; Region: Psb28; cl04326 41431009098 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 41431009099 TIGR01777 family protein; Region: yfcH 41431009100 putative NAD(P) binding site [chemical binding]; other site 41431009101 putative active site [active] 41431009102 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 41431009103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431009104 Walker A motif; other site 41431009105 ATP binding site [chemical binding]; other site 41431009106 Walker B motif; other site 41431009107 arginine finger; other site 41431009108 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 41431009109 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 41431009110 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431009111 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431009112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431009113 Probable transposase; Region: OrfB_IS605; pfam01385 41431009114 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431009115 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 41431009116 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 41431009117 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431009118 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 41431009119 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 41431009120 dimer interface [polypeptide binding]; other site 41431009121 putative functional site; other site 41431009122 putative MPT binding site; other site 41431009123 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 41431009124 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 41431009125 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 41431009126 substrate binding site [chemical binding]; other site 41431009127 catalytic Zn binding site [ion binding]; other site 41431009128 NAD binding site [chemical binding]; other site 41431009129 structural Zn binding site [ion binding]; other site 41431009130 dimer interface [polypeptide binding]; other site 41431009131 Acylphosphatase; Region: Acylphosphatase; cl00551 41431009132 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 41431009133 HypF finger; Region: zf-HYPF; pfam07503 41431009134 HypF finger; Region: zf-HYPF; pfam07503 41431009135 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 41431009136 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 41431009137 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 41431009138 active site 41431009139 dimer interface [polypeptide binding]; other site 41431009140 catalytic nucleophile [active] 41431009141 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 41431009142 Flagellin N-methylase; Region: FliB; cl00497 41431009143 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 41431009144 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 41431009145 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431009146 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431009147 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 41431009148 EamA-like transporter family; Region: EamA; cl01037 41431009149 EamA-like transporter family; Region: EamA; cl01037 41431009150 Domain of unknown function (DUF477); Region: DUF477; cl01535 41431009151 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 41431009152 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 41431009153 P loop; other site 41431009154 Nucleotide binding site [chemical binding]; other site 41431009155 DTAP/Switch II; other site 41431009156 Switch I; other site 41431009157 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 41431009158 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 41431009159 putative dimer interface [polypeptide binding]; other site 41431009160 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 41431009161 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 41431009162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431009163 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 41431009164 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431009165 Flavin Reductases; Region: FlaRed; cl00801 41431009166 Phosphate-starvation-inducible E; Region: PsiE; cl01264 41431009167 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 41431009168 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431009169 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 41431009170 Flavin Reductases; Region: FlaRed; cl00801 41431009171 CHASE2 domain; Region: CHASE2; cl01732 41431009172 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 41431009173 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 41431009174 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 41431009175 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431009176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431009177 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 41431009178 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 41431009179 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 41431009180 dimer interface [polypeptide binding]; other site 41431009181 substrate binding site [chemical binding]; other site 41431009182 catalytic triad [active] 41431009183 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 41431009184 putative catalytic residues [active] 41431009185 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 41431009186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431009187 dimer interface [polypeptide binding]; other site 41431009188 conserved gate region; other site 41431009189 putative PBP binding loops; other site 41431009190 ABC-ATPase subunit interface; other site 41431009191 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 41431009192 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 41431009193 metal-binding site [ion binding] 41431009194 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431009195 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 41431009196 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 41431009197 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 41431009198 DNA binding residues [nucleotide binding] 41431009199 dimer interface [polypeptide binding]; other site 41431009200 metal binding site [ion binding]; metal-binding site 41431009201 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 41431009202 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 41431009203 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431009204 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431009205 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431009206 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431009207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009208 active site 41431009209 phosphorylation site [posttranslational modification] 41431009210 intermolecular recognition site; other site 41431009211 dimerization interface [polypeptide binding]; other site 41431009212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431009213 DNA binding site [nucleotide binding] 41431009214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431009215 dimer interface [polypeptide binding]; other site 41431009216 phosphorylation site [posttranslational modification] 41431009217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431009218 ATP binding site [chemical binding]; other site 41431009219 Mg2+ binding site [ion binding]; other site 41431009220 G-X-G motif; other site 41431009221 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 41431009222 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 41431009223 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 41431009224 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 41431009225 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 41431009226 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 41431009227 conserved cys residue [active] 41431009228 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 41431009229 PemK-like protein; Region: PemK; cl00995 41431009230 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 41431009231 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 41431009232 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431009233 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 41431009234 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 41431009235 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 41431009236 dimer interface [polypeptide binding]; other site 41431009237 motif 1; other site 41431009238 active site 41431009239 motif 2; other site 41431009240 motif 3; other site 41431009241 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009242 putative active site [active] 41431009243 Survival protein SurE; Region: SurE; cl00448 41431009244 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 41431009245 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 41431009246 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 41431009247 Flavoprotein; Region: Flavoprotein; cl08021 41431009248 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 41431009249 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431009250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009251 binding surface 41431009252 TPR motif; other site 41431009253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009254 binding surface 41431009255 TPR motif; other site 41431009256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009257 binding surface 41431009258 TPR motif; other site 41431009259 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 41431009260 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 41431009261 tRNA; other site 41431009262 putative tRNA binding site [nucleotide binding]; other site 41431009263 putative NADP binding site [chemical binding]; other site 41431009264 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 41431009265 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 41431009266 putative active site [active] 41431009267 PemK-like protein; Region: PemK; cl00995 41431009268 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 41431009269 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 41431009270 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 41431009271 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009272 putative active site [active] 41431009273 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 41431009274 FOG: CBS domain [General function prediction only]; Region: COG0517 41431009275 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 41431009276 CP12 domain; Region: CP12; cl14670 41431009277 Staphylococcal nuclease homologues; Region: SNc; smart00318 41431009278 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 41431009279 Catalytic site; other site 41431009280 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 41431009281 putative active site [active] 41431009282 catalytic residue [active] 41431009283 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793 41431009284 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 41431009285 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 41431009286 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 41431009287 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 41431009288 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 41431009289 alpha subunit interaction interface [polypeptide binding]; other site 41431009290 Walker A motif; other site 41431009291 ATP binding site [chemical binding]; other site 41431009292 Walker B motif; other site 41431009293 inhibitor binding site; inhibition site 41431009294 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 41431009295 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 41431009296 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 41431009297 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 41431009298 nudix motif; other site 41431009299 argininosuccinate lyase; Provisional; Region: PRK00855 41431009300 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 41431009301 active sites [active] 41431009302 tetramer interface [polypeptide binding]; other site 41431009303 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 41431009304 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 41431009305 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 41431009306 Response regulator receiver domain; Region: Response_reg; pfam00072 41431009307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009308 active site 41431009309 phosphorylation site [posttranslational modification] 41431009310 intermolecular recognition site; other site 41431009311 dimerization interface [polypeptide binding]; other site 41431009312 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431009313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009314 active site 41431009315 phosphorylation site [posttranslational modification] 41431009316 intermolecular recognition site; other site 41431009317 dimerization interface [polypeptide binding]; other site 41431009318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431009319 DNA binding site [nucleotide binding] 41431009320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009321 active site 41431009322 phosphorylation site [posttranslational modification] 41431009323 intermolecular recognition site; other site 41431009324 dimerization interface [polypeptide binding]; other site 41431009325 Response regulator receiver domain; Region: Response_reg; pfam00072 41431009326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009327 active site 41431009328 phosphorylation site [posttranslational modification] 41431009329 intermolecular recognition site; other site 41431009330 dimerization interface [polypeptide binding]; other site 41431009331 excinuclease ABC subunit B; Provisional; Region: PRK05298 41431009332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431009333 ATP binding site [chemical binding]; other site 41431009334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431009335 nucleotide binding region [chemical binding]; other site 41431009336 ATP-binding site [chemical binding]; other site 41431009337 Ultra-violet resistance protein B; Region: UvrB; pfam12344 41431009338 UvrB/uvrC motif; Region: UVR; pfam02151 41431009339 HlyD family secretion protein; Region: HlyD; pfam00529 41431009340 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431009341 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 41431009342 Protein export membrane protein; Region: SecD_SecF; cl14618 41431009343 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 41431009344 active site 41431009345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431009346 dimer interface [polypeptide binding]; other site 41431009347 conserved gate region; other site 41431009348 putative PBP binding loops; other site 41431009349 ABC-ATPase subunit interface; other site 41431009350 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431009351 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 41431009352 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 41431009353 Walker A/P-loop; other site 41431009354 ATP binding site [chemical binding]; other site 41431009355 Q-loop/lid; other site 41431009356 ABC transporter signature motif; other site 41431009357 Walker B; other site 41431009358 D-loop; other site 41431009359 H-loop/switch region; other site 41431009360 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 41431009361 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 41431009362 active site 41431009363 metal binding site [ion binding]; metal-binding site 41431009364 UbiA prenyltransferase family; Region: UbiA; cl00337 41431009365 H+ Antiporter protein; Region: 2A0121; TIGR00900 41431009366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431009367 putative substrate translocation pore; other site 41431009368 peptide synthase; Provisional; Region: PRK12467 41431009369 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009370 PilZ domain; Region: PilZ; cl01260 41431009371 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009372 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431009373 peptide synthase; Provisional; Region: PRK12467 41431009374 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009375 PilZ domain; Region: PilZ; cl01260 41431009376 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009377 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 41431009378 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431009379 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 41431009380 peptide synthase; Provisional; Region: PRK12467 41431009381 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 41431009382 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 41431009383 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431009384 peptide synthase; Provisional; Region: PRK12467 41431009385 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009386 PilZ domain; Region: PilZ; cl01260 41431009387 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009388 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431009389 peptide synthase; Provisional; Region: PRK12467 41431009390 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009391 PilZ domain; Region: PilZ; cl01260 41431009392 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009393 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431009394 peptide synthase; Provisional; Region: PRK12467 41431009395 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009396 PilZ domain; Region: PilZ; cl01260 41431009397 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009398 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431009399 acyl-CoA synthetase; Validated; Region: PRK05850 41431009400 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431009401 Phosphopantetheine attachment site; Region: PP-binding; cl09936 41431009402 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 41431009403 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 41431009404 dimerization interface [polypeptide binding]; other site 41431009405 ATP binding site [chemical binding]; other site 41431009406 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 41431009407 dimerization interface [polypeptide binding]; other site 41431009408 ATP binding site [chemical binding]; other site 41431009409 Restriction endonuclease; Region: Mrr_cat; cl00747 41431009410 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431009411 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431009412 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 41431009413 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 41431009414 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 41431009415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431009416 FeS/SAM binding site; other site 41431009417 TMAO/DMSO reductase; Reviewed; Region: PRK05363 41431009418 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 41431009419 Moco binding site; other site 41431009420 metal coordination site [ion binding]; other site 41431009421 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 41431009422 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 41431009423 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431009424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431009425 motif II; other site 41431009426 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 41431009427 CemA family; Region: CemA; cl03855 41431009428 thioester reductase domain; Region: Thioester-redct; TIGR01746 41431009429 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 41431009430 putative NAD(P) binding site [chemical binding]; other site 41431009431 active site 41431009432 putative substrate binding site [chemical binding]; other site 41431009433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 41431009434 dimerization interface [polypeptide binding]; other site 41431009435 putative DNA binding site [nucleotide binding]; other site 41431009436 putative Zn2+ binding site [ion binding]; other site 41431009437 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009438 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009439 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009440 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009441 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009442 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 41431009443 diiron binding motif [ion binding]; other site 41431009444 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 41431009445 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 41431009446 active site 41431009447 catalytic residues [active] 41431009448 PemK-like protein; Region: PemK; cl00995 41431009449 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 41431009450 dinuclear metal binding motif [ion binding]; other site 41431009451 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 41431009452 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 41431009453 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 41431009454 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 41431009455 generic binding surface I; other site 41431009456 generic binding surface II; other site 41431009457 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 41431009458 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 41431009459 Probable Catalytic site; other site 41431009460 metal-binding site 41431009461 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 41431009462 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 41431009463 short chain dehydrogenase; Provisional; Region: PRK06197 41431009464 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 41431009465 putative NAD(P) binding site [chemical binding]; other site 41431009466 active site 41431009467 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431009468 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 41431009469 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 41431009470 aromatic acid decarboxylase; Validated; Region: PRK05920 41431009471 Flavoprotein; Region: Flavoprotein; cl08021 41431009472 ubiquitin-activating enzyme E1; Region: Ube1; TIGR01408 41431009473 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 41431009474 catalytic triad [active] 41431009475 conserved cis-peptide bond; other site 41431009476 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431009477 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 41431009478 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 41431009479 putative NAD(P) binding site [chemical binding]; other site 41431009480 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431009481 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 41431009482 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 41431009483 active site 41431009484 dimer interface [polypeptide binding]; other site 41431009485 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 41431009486 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 41431009487 active site 41431009488 FMN binding site [chemical binding]; other site 41431009489 substrate binding site [chemical binding]; other site 41431009490 3Fe-4S cluster binding site [ion binding]; other site 41431009491 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 41431009492 domain interface; other site 41431009493 Protein of unknown function (DUF497); Region: DUF497; cl01108 41431009494 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 41431009495 conserved hypothetical protein; Region: QEGLA; TIGR02421 41431009496 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 41431009497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431009498 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009499 putative active site [active] 41431009500 Phycobilisome protein; Region: Phycobilisome; cl08227 41431009501 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 41431009502 DHH family; Region: DHH; pfam01368 41431009503 FOG: CBS domain [General function prediction only]; Region: COG0517 41431009504 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 41431009505 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 41431009506 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 41431009507 active site 41431009508 NTP binding site [chemical binding]; other site 41431009509 metal binding triad [ion binding]; metal-binding site 41431009510 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 41431009511 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 41431009512 GIY-YIG motif/motif A; other site 41431009513 active site 41431009514 catalytic site [active] 41431009515 metal binding site [ion binding]; metal-binding site 41431009516 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 41431009517 Probable Catalytic site; other site 41431009518 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 41431009519 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431009520 putative metal binding site [ion binding]; other site 41431009521 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431009522 active site 41431009523 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 41431009524 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 41431009525 putative dimer interface [polypeptide binding]; other site 41431009526 N-terminal domain interface [polypeptide binding]; other site 41431009527 putative substrate binding pocket (H-site) [chemical binding]; other site 41431009528 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 41431009529 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 41431009530 Walker A/P-loop; other site 41431009531 ATP binding site [chemical binding]; other site 41431009532 Q-loop/lid; other site 41431009533 ABC transporter signature motif; other site 41431009534 Walker B; other site 41431009535 D-loop; other site 41431009536 H-loop/switch region; other site 41431009537 DevC protein; Region: devC; TIGR01185 41431009538 FtsX-like permease family; Region: FtsX; pfam02687 41431009539 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 41431009540 Response regulator receiver domain; Region: Response_reg; pfam00072 41431009541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009542 active site 41431009543 phosphorylation site [posttranslational modification] 41431009544 intermolecular recognition site; other site 41431009545 dimerization interface [polypeptide binding]; other site 41431009546 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 41431009547 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 41431009548 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 41431009549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009550 active site 41431009551 phosphorylation site [posttranslational modification] 41431009552 intermolecular recognition site; other site 41431009553 dimerization interface [polypeptide binding]; other site 41431009554 CheB methylesterase; Region: CheB_methylest; pfam01339 41431009555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 41431009556 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 41431009557 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 41431009558 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 41431009559 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 41431009560 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 41431009561 P loop; other site 41431009562 GTP binding site [chemical binding]; other site 41431009563 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 41431009564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431009565 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 41431009566 substrate binding site [chemical binding]; other site 41431009567 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431009568 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009569 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009570 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009571 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009572 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009573 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009575 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 41431009576 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431009577 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 41431009578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431009579 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 41431009580 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431009581 Response regulator receiver domain; Region: Response_reg; pfam00072 41431009582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009583 active site 41431009584 phosphorylation site [posttranslational modification] 41431009585 intermolecular recognition site; other site 41431009586 dimerization interface [polypeptide binding]; other site 41431009587 GAF domain; Region: GAF; cl00853 41431009588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431009589 metal binding site [ion binding]; metal-binding site 41431009590 active site 41431009591 I-site; other site 41431009592 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 41431009593 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 41431009594 Walker A/P-loop; other site 41431009595 ATP binding site [chemical binding]; other site 41431009596 Q-loop/lid; other site 41431009597 ABC transporter signature motif; other site 41431009598 Walker B; other site 41431009599 D-loop; other site 41431009600 H-loop/switch region; other site 41431009601 Smr domain; Region: Smr; cl02619 41431009602 NC domain; Region: NC; pfam04970 41431009603 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 41431009604 Predicted transcriptional regulators [Transcription]; Region: COG1725 41431009605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 41431009606 DNA-binding site [nucleotide binding]; DNA binding site 41431009607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431009608 dimer interface [polypeptide binding]; other site 41431009609 conserved gate region; other site 41431009610 ABC-ATPase subunit interface; other site 41431009611 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 41431009612 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 41431009613 META domain; Region: META; cl01245 41431009614 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431009615 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 41431009616 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 41431009617 dimer interface [polypeptide binding]; other site 41431009618 N-terminal domain interface [polypeptide binding]; other site 41431009619 substrate binding pocket (H-site) [chemical binding]; other site 41431009620 DoxX; Region: DoxX; cl00976 41431009621 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 41431009622 DNA primase; Validated; Region: dnaG; PRK05667 41431009623 CHC2 zinc finger; Region: zf-CHC2; cl15369 41431009624 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 41431009625 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 41431009626 active site 41431009627 metal binding site [ion binding]; metal-binding site 41431009628 interdomain interaction site; other site 41431009629 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 41431009630 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 41431009631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 41431009632 DNA-binding site [nucleotide binding]; DNA binding site 41431009633 UTRA domain; Region: UTRA; cl01230 41431009634 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 41431009635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431009636 Walker A/P-loop; other site 41431009637 ATP binding site [chemical binding]; other site 41431009638 Q-loop/lid; other site 41431009639 ABC transporter signature motif; other site 41431009640 Walker B; other site 41431009641 D-loop; other site 41431009642 H-loop/switch region; other site 41431009643 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 41431009644 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 41431009645 Walker A/P-loop; other site 41431009646 ATP binding site [chemical binding]; other site 41431009647 Q-loop/lid; other site 41431009648 ABC transporter signature motif; other site 41431009649 Walker B; other site 41431009650 D-loop; other site 41431009651 H-loop/switch region; other site 41431009652 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 41431009653 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 41431009654 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 41431009655 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 41431009656 DNA binding residues [nucleotide binding] 41431009657 dimer interface [polypeptide binding]; other site 41431009658 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 41431009659 homodimer interface [polypeptide binding]; other site 41431009660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431009661 catalytic residue [active] 41431009662 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 41431009663 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009664 putative active site [active] 41431009665 Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958 41431009666 NodB motif; other site 41431009667 putative active site [active] 41431009668 putative catalytic site [active] 41431009669 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 41431009670 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431009671 HSP70 interaction site [polypeptide binding]; other site 41431009672 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 41431009673 Rrf2 family protein; Region: rrf2_super; TIGR00738 41431009674 Helix-turn-helix domains; Region: HTH; cl00088 41431009675 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 41431009676 CobD/Cbib protein; Region: CobD_Cbib; cl00561 41431009677 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 41431009678 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 41431009679 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 41431009680 opcA protein; Region: OpcA; TIGR00534 41431009681 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 41431009682 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 41431009683 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 41431009684 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 41431009685 Uncharacterized conserved protein [Function unknown]; Region: COG1565 41431009686 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 41431009687 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 41431009688 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 41431009689 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 41431009690 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 41431009691 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 41431009692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431009693 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 41431009694 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431009695 active site 41431009696 metal binding site [ion binding]; metal-binding site 41431009697 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431009698 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 41431009699 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 41431009700 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 41431009701 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 41431009702 Ligand Binding Site [chemical binding]; other site 41431009703 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 41431009704 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 41431009705 putative active site [active] 41431009706 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 41431009707 putative metal binding site; other site 41431009708 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 41431009709 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 41431009710 putative active site [active] 41431009711 TIGR03790 family protein; Region: TIGR03790 41431009712 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 41431009713 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 41431009714 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 41431009715 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431009716 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 41431009717 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 41431009718 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 41431009719 putative active site [active] 41431009720 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 41431009721 putative active site [active] 41431009722 Cytochrome c; Region: Cytochrom_C; cl11414 41431009723 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009724 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 41431009725 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 41431009726 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 41431009727 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 41431009728 RDD family; Region: RDD; cl00746 41431009729 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 41431009730 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 41431009731 putative active site cavity [active] 41431009732 RFC reduced folate carrier; Region: rfc; TIGR00806 41431009733 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 41431009734 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431009735 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431009736 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 41431009737 dimer interface [polypeptide binding]; other site 41431009738 active site 41431009739 metal binding site [ion binding]; metal-binding site 41431009740 glutathione binding site [chemical binding]; other site 41431009741 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 41431009742 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 41431009743 pheophytin binding site; other site 41431009744 chlorophyll binding site; other site 41431009745 quinone binding site; other site 41431009746 Fe binding site [ion binding]; other site 41431009747 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009748 putative active site [active] 41431009749 tellurium resistance terB-like protein; Region: terB_like; cd07177 41431009750 metal binding site [ion binding]; metal-binding site 41431009751 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 41431009752 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 41431009753 G1 box; other site 41431009754 GTP/Mg2+ binding site [chemical binding]; other site 41431009755 Switch I region; other site 41431009756 G2 box; other site 41431009757 Switch II region; other site 41431009758 G3 box; other site 41431009759 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 41431009760 G1 box; other site 41431009761 GTP/Mg2+ binding site [chemical binding]; other site 41431009762 Switch I region; other site 41431009763 G2 box; other site 41431009764 Switch II region; other site 41431009765 G3 box; other site 41431009766 G4 box; other site 41431009767 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 41431009768 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 41431009769 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 41431009770 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 41431009771 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 41431009772 active site 41431009773 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 41431009774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431009775 dimer interface [polypeptide binding]; other site 41431009776 conserved gate region; other site 41431009777 putative PBP binding loops; other site 41431009778 ABC-ATPase subunit interface; other site 41431009779 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 41431009780 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 41431009781 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 41431009782 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 41431009783 Walker A/P-loop; other site 41431009784 ATP binding site [chemical binding]; other site 41431009785 Q-loop/lid; other site 41431009786 ABC transporter signature motif; other site 41431009787 Walker B; other site 41431009788 D-loop; other site 41431009789 H-loop/switch region; other site 41431009790 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009791 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009792 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009793 multifunctional aminopeptidase A; Provisional; Region: PRK00913 41431009794 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 41431009795 interface (dimer of trimers) [polypeptide binding]; other site 41431009796 Substrate-binding/catalytic site; other site 41431009797 Zn-binding sites [ion binding]; other site 41431009798 CHRD domain; Region: CHRD; cl06473 41431009799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431009800 S-adenosylmethionine binding site [chemical binding]; other site 41431009801 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431009802 structural tetrad; other site 41431009803 PspA/IM30 family; Region: PspA_IM30; pfam04012 41431009804 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 41431009805 catalytic residues [active] 41431009806 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 41431009807 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431009808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431009809 homodimer interface [polypeptide binding]; other site 41431009810 catalytic residue [active] 41431009811 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 41431009812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431009813 non-specific DNA binding site [nucleotide binding]; other site 41431009814 salt bridge; other site 41431009815 sequence-specific DNA binding site [nucleotide binding]; other site 41431009816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431009817 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009818 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009819 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 41431009820 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431009821 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 41431009822 putative NAD(P) binding site [chemical binding]; other site 41431009823 active site 41431009824 putative substrate binding site [chemical binding]; other site 41431009825 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431009826 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431009827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431009828 active site 41431009829 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 41431009830 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 41431009831 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 41431009832 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 41431009833 Walker A/P-loop; other site 41431009834 ATP binding site [chemical binding]; other site 41431009835 Q-loop/lid; other site 41431009836 ABC transporter signature motif; other site 41431009837 Walker B; other site 41431009838 D-loop; other site 41431009839 H-loop/switch region; other site 41431009840 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 41431009841 putative carbohydrate binding site [chemical binding]; other site 41431009842 ABC-2 type transporter; Region: ABC2_membrane; cl11417 41431009843 G8 domain; Region: G8; pfam10162 41431009844 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 41431009845 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431009846 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 41431009847 Ligand binding site; other site 41431009848 Putative Catalytic site; other site 41431009849 DXD motif; other site 41431009850 GtrA-like protein; Region: GtrA; cl00971 41431009851 Acetokinase family; Region: Acetate_kinase; cl01029 41431009852 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 41431009853 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 41431009854 putative metal binding residues [ion binding]; other site 41431009855 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 41431009856 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 41431009857 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 41431009858 ABC-ATPase subunit interface; other site 41431009859 dimer interface [polypeptide binding]; other site 41431009860 putative PBP binding regions; other site 41431009861 Major royal jelly protein; Region: MRJP; pfam03022 41431009862 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 41431009863 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 41431009864 DNA binding residues [nucleotide binding] 41431009865 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 41431009866 catalytic residues [active] 41431009867 catalytic nucleophile [active] 41431009868 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431009869 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009870 putative active site [active] 41431009871 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431009872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009873 binding surface 41431009874 TPR motif; other site 41431009875 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 41431009876 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431009877 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 41431009878 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 41431009879 inhibitor-cofactor binding pocket; inhibition site 41431009880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431009881 catalytic residue [active] 41431009882 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431009883 Probable transposase; Region: OrfB_IS605; pfam01385 41431009884 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431009885 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431009886 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 41431009887 TROVE domain; Region: TROVE; pfam05731 41431009888 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 41431009889 metal ion-dependent adhesion site (MIDAS); other site 41431009890 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 41431009891 active site 41431009892 dimer interface [polypeptide binding]; other site 41431009893 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 41431009894 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 41431009895 Abi-like protein; Region: Abi_2; cl01988 41431009896 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 41431009897 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 41431009898 dimer interface [polypeptide binding]; other site 41431009899 PYR/PP interface [polypeptide binding]; other site 41431009900 TPP binding site [chemical binding]; other site 41431009901 substrate binding site [chemical binding]; other site 41431009902 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 41431009903 Domain of unknown function; Region: EKR; cl11037 41431009904 4Fe-4S binding domain; Region: Fer4; cl02805 41431009905 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 41431009906 TPP-binding site [chemical binding]; other site 41431009907 dimer interface [polypeptide binding]; other site 41431009908 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 41431009909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431009910 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 41431009911 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431009912 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009913 putative active site [active] 41431009914 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 41431009915 catalytic residues [active] 41431009916 dimer interface [polypeptide binding]; other site 41431009917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431009918 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009919 putative active site [active] 41431009920 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 41431009921 NAD(P) binding site [chemical binding]; other site 41431009922 putative active site [active] 41431009923 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 41431009924 6-phosphofructokinase; Provisional; Region: PRK03202 41431009925 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 41431009926 active site 41431009927 ADP/pyrophosphate binding site [chemical binding]; other site 41431009928 dimerization interface [polypeptide binding]; other site 41431009929 allosteric effector site; other site 41431009930 fructose-1,6-bisphosphate binding site; other site 41431009931 phosphoribulokinase; Provisional; Region: PRK07429 41431009932 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 41431009933 active site 41431009934 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431009935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009936 active site 41431009937 phosphorylation site [posttranslational modification] 41431009938 intermolecular recognition site; other site 41431009939 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 41431009940 tetramer interface [polypeptide binding]; other site 41431009941 dimer interface [polypeptide binding]; other site 41431009942 circadian clock protein KaiC; Reviewed; Region: PRK09302 41431009943 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 41431009944 Walker A motif; other site 41431009945 ATP binding site [chemical binding]; other site 41431009946 Walker B motif; other site 41431009947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431009948 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431009949 Walker A motif; other site 41431009950 ATP binding site [chemical binding]; other site 41431009951 Walker B motif; other site 41431009952 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 41431009953 HsdM N-terminal domain; Region: HsdM_N; pfam12161 41431009954 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 41431009955 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 41431009956 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 41431009957 oligomeric interface; other site 41431009958 putative active site [active] 41431009959 homodimer interface [polypeptide binding]; other site 41431009960 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431009961 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 41431009962 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431009963 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 41431009964 oligomeric interface; other site 41431009965 putative active site [active] 41431009966 homodimer interface [polypeptide binding]; other site 41431009967 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 41431009968 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 41431009969 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 41431009970 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 41431009971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431009972 Probable transposase; Region: OrfB_IS605; pfam01385 41431009973 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431009974 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 41431009975 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 41431009976 glutaminase active site [active] 41431009977 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 41431009978 dimer interface [polypeptide binding]; other site 41431009979 active site 41431009980 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 41431009981 dimer interface [polypeptide binding]; other site 41431009982 active site 41431009983 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 41431009984 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 41431009985 Integrase core domain; Region: rve; cl01316 41431009986 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 41431009987 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 41431009988 Transposase [DNA replication, recombination, and repair]; Region: COG5433 41431009989 Transposase [DNA replication, recombination, and repair]; Region: COG5433 41431009990 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 41431009991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431009992 hypothetical protein; Provisional; Region: PRK06753 41431009993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431009994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431009995 Helix-turn-helix domains; Region: HTH; cl00088 41431009996 FOG: CBS domain [General function prediction only]; Region: COG0517 41431009997 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 41431009998 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 41431009999 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 41431010000 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 41431010001 active site 41431010002 catalytic residues [active] 41431010003 metal binding site [ion binding]; metal-binding site 41431010004 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 41431010005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431010006 NAD(P) binding site [chemical binding]; other site 41431010007 active site 41431010008 hypothetical protein; Provisional; Region: PRK06847 41431010009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431010010 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 41431010011 isocitrate dehydrogenase; Validated; Region: PRK07362 41431010012 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 41431010013 5' RNA guide strand anchoring site; other site 41431010014 active site 41431010015 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 41431010016 DNA binding residues [nucleotide binding] 41431010017 putative dimer interface [polypeptide binding]; other site 41431010018 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 41431010019 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 41431010020 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 41431010021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431010022 Walker A/P-loop; other site 41431010023 ATP binding site [chemical binding]; other site 41431010024 Q-loop/lid; other site 41431010025 ABC transporter signature motif; other site 41431010026 Walker B; other site 41431010027 D-loop; other site 41431010028 H-loop/switch region; other site 41431010029 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 41431010030 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 41431010031 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 41431010032 active site 41431010033 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 41431010034 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431010035 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431010036 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 41431010037 Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205 41431010038 DsrE/DsrF-like family; Region: DrsE; cl00672 41431010039 DsrE/DsrF-like family; Region: DrsE; cl00672 41431010040 DsrE/DsrF-like family; Region: DrsE; cl00672 41431010041 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431010042 Ligand Binding Site [chemical binding]; other site 41431010043 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431010044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010045 active site 41431010046 phosphorylation site [posttranslational modification] 41431010047 intermolecular recognition site; other site 41431010048 dimerization interface [polypeptide binding]; other site 41431010049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431010050 DNA binding site [nucleotide binding] 41431010051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 41431010052 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 41431010053 Uncharacterized conserved protein [Function unknown]; Region: COG1432 41431010054 LabA_like proteins; Region: LabA; cd10911 41431010055 putative metal binding site [ion binding]; other site 41431010056 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 41431010057 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 41431010058 active site 41431010059 HIGH motif; other site 41431010060 KMSKS motif; other site 41431010061 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 41431010062 tRNA binding surface [nucleotide binding]; other site 41431010063 anticodon binding site; other site 41431010064 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431010065 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431010066 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 41431010067 active site 41431010068 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 41431010069 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 41431010070 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431010071 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 41431010072 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 41431010073 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 41431010074 ligand-binding site [chemical binding]; other site 41431010075 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 41431010076 Leucine-rich repeats; other site 41431010077 Substrate binding site [chemical binding]; other site 41431010078 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 41431010079 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cd00882 41431010080 G1 box; other site 41431010081 GTP/Mg2+ binding site [chemical binding]; other site 41431010082 G2 box; other site 41431010083 Switch I region; other site 41431010084 G3 box; other site 41431010085 Switch II region; other site 41431010086 G4 box; other site 41431010087 G5 box; other site 41431010088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431010089 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 41431010090 active site 41431010091 motif I; other site 41431010092 motif II; other site 41431010093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431010094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431010095 S-adenosylmethionine binding site [chemical binding]; other site 41431010096 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 41431010097 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 41431010098 FtsX-like permease family; Region: FtsX; pfam02687 41431010099 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 41431010100 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431010101 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 41431010102 glutathione synthetase; Provisional; Region: PRK05246 41431010103 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 41431010104 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 41431010105 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 41431010106 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 41431010107 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 41431010108 cell division protein ZipA; Provisional; Region: PRK03427 41431010109 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 41431010110 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 41431010111 active site 41431010112 hydrophilic channel; other site 41431010113 dimerization interface [polypeptide binding]; other site 41431010114 catalytic residues [active] 41431010115 active site lid [active] 41431010116 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431010117 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431010118 putative binding surface; other site 41431010119 active site 41431010120 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 41431010121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431010122 ATP binding site [chemical binding]; other site 41431010123 Mg2+ binding site [ion binding]; other site 41431010124 G-X-G motif; other site 41431010125 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431010126 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010128 active site 41431010129 phosphorylation site [posttranslational modification] 41431010130 intermolecular recognition site; other site 41431010131 dimerization interface [polypeptide binding]; other site 41431010132 GAF domain; Region: GAF; cl00853 41431010133 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431010134 GAF domain; Region: GAF; cl00853 41431010135 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431010136 GAF domain; Region: GAF; cl00853 41431010137 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431010138 GAF domain; Region: GAF; cl00853 41431010139 GAF domain; Region: GAF; cl00853 41431010140 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431010141 GAF domain; Region: GAF; cl00853 41431010142 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431010143 GAF domain; Region: GAF; cl00853 41431010144 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431010145 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 41431010146 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431010147 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010149 active site 41431010150 phosphorylation site [posttranslational modification] 41431010151 intermolecular recognition site; other site 41431010152 dimerization interface [polypeptide binding]; other site 41431010153 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 41431010154 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 41431010155 homotetramer interface [polypeptide binding]; other site 41431010156 FMN binding site [chemical binding]; other site 41431010157 homodimer contacts [polypeptide binding]; other site 41431010158 putative active site [active] 41431010159 putative substrate binding site [chemical binding]; other site 41431010160 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431010161 Ligand Binding Site [chemical binding]; other site 41431010162 PhoD-like phosphatase; Region: PhoD; pfam09423 41431010163 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 41431010164 putative active site [active] 41431010165 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431010166 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 41431010167 putative dimer interface [polypeptide binding]; other site 41431010168 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 41431010169 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 41431010170 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 41431010171 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 41431010172 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 41431010173 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 41431010174 MoaE interaction surface [polypeptide binding]; other site 41431010175 thiocarboxylated glycine; other site 41431010176 threonine synthase; Validated; Region: PRK07591 41431010177 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 41431010178 homodimer interface [polypeptide binding]; other site 41431010179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431010180 catalytic residue [active] 41431010181 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010182 putative active site [active] 41431010183 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 41431010184 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 41431010185 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 41431010186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 41431010187 Helix-turn-helix domains; Region: HTH; cl00088 41431010188 Transposase; Region: DDE_Tnp_ISL3; pfam01610 41431010189 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431010190 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431010191 active site 41431010192 ATP binding site [chemical binding]; other site 41431010193 substrate binding site [chemical binding]; other site 41431010194 activation loop (A-loop); other site 41431010195 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 41431010196 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 41431010197 acyl-CoA synthetase; Validated; Region: PRK05850 41431010198 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 41431010199 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 41431010200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431010201 motif II; other site 41431010202 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 41431010203 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 41431010204 active site 41431010205 substrate-binding site [chemical binding]; other site 41431010206 metal-binding site [ion binding] 41431010207 ATP binding site [chemical binding]; other site 41431010208 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431010209 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 41431010210 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431010211 catalytic residue [active] 41431010212 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431010213 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 41431010214 StbA protein; Region: StbA; pfam06406 41431010215 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 41431010216 Fe-S cluster binding site [ion binding]; other site 41431010217 active site 41431010218 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 41431010219 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 41431010220 Walker A/P-loop; other site 41431010221 ATP binding site [chemical binding]; other site 41431010222 Q-loop/lid; other site 41431010223 ABC transporter signature motif; other site 41431010224 Walker B; other site 41431010225 D-loop; other site 41431010226 H-loop/switch region; other site 41431010227 Bacterial SH3 domain; Region: SH3_3; cl02551 41431010228 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 41431010229 putative hexamer interface [polypeptide binding]; other site 41431010230 putative hexagonal pore; other site 41431010231 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 41431010232 Hexamer interface [polypeptide binding]; other site 41431010233 Hexagonal pore residue; other site 41431010234 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431010235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431010236 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 41431010237 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 41431010238 Cation transport protein; Region: TrkH; cl10514 41431010239 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 41431010240 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 41431010241 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 41431010242 G-X-X-G motif; other site 41431010243 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 41431010244 RxxxH motif; other site 41431010245 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 41431010246 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 41431010247 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 41431010248 Ribonuclease P; Region: Ribonuclease_P; cl00457 41431010249 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 41431010250 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 41431010251 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 41431010252 ligand binding site; other site 41431010253 oligomer interface; other site 41431010254 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 41431010255 dimer interface [polypeptide binding]; other site 41431010256 N-terminal domain interface [polypeptide binding]; other site 41431010257 sulfate 1 binding site; other site 41431010258 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 41431010259 S-layer homology domain; Region: SLH; pfam00395 41431010260 S-layer homology domain; Region: SLH; pfam00395 41431010261 Ferritin-like domain; Region: Ferritin; pfam00210 41431010262 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 41431010263 dimerization interface [polypeptide binding]; other site 41431010264 DPS ferroxidase diiron center [ion binding]; other site 41431010265 ion pore; other site 41431010266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 41431010267 Domain of unknown function DUF140; Region: DUF140; cl00510 41431010268 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 41431010269 Domain of unknown function DUF59; Region: DUF59; cl00941 41431010270 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 41431010271 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 41431010272 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 41431010273 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431010274 putative binding surface; other site 41431010275 active site 41431010276 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 41431010277 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 41431010278 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 41431010279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431010280 FeS/SAM binding site; other site 41431010281 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 41431010282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431010283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431010284 S-adenosylmethionine binding site [chemical binding]; other site 41431010285 phosphoethanolamine N-methyltransferase; Region: PLN02336 41431010286 GUN4-like; Region: GUN4; pfam05419 41431010287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 41431010288 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431010289 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 41431010290 RimM N-terminal domain; Region: RimM; pfam01782 41431010291 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 41431010292 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 41431010293 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 41431010294 ATP adenylyltransferase; Region: ATP_transf; pfam09830 41431010295 LysE type translocator; Region: LysE; cl00565 41431010296 magnesium chelatase subunit H; Provisional; Region: PLN03241 41431010297 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431010298 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431010299 TRAM domain; Region: TRAM; cl01282 41431010300 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 41431010301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431010302 S-adenosylmethionine binding site [chemical binding]; other site 41431010303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 41431010304 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 41431010305 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 41431010306 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 41431010307 GTP/Mg2+ binding site [chemical binding]; other site 41431010308 G4 box; other site 41431010309 G5 box; other site 41431010310 G1 box; other site 41431010311 Switch I region; other site 41431010312 G2 box; other site 41431010313 G3 box; other site 41431010314 Switch II region; other site 41431010315 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 41431010316 ligand binding surface [chemical binding]; other site 41431010317 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 41431010318 Competence protein; Region: Competence; cl00471 41431010319 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431010320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431010321 dimer interface [polypeptide binding]; other site 41431010322 phosphorylation site [posttranslational modification] 41431010323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431010324 ATP binding site [chemical binding]; other site 41431010325 Mg2+ binding site [ion binding]; other site 41431010326 G-X-G motif; other site 41431010327 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 41431010328 Creatinine amidohydrolase; Region: Creatininase; cl00618 41431010329 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 41431010330 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 41431010331 Putative esterase; Region: Esterase; pfam00756 41431010332 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431010333 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431010334 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 41431010335 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 41431010336 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 41431010337 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 41431010338 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 41431010339 Domain of unknown function DUF21; Region: DUF21; pfam01595 41431010340 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 41431010341 Transporter associated domain; Region: CorC_HlyC; cl08393 41431010342 Chromate transporter; Region: Chromate_transp; pfam02417 41431010343 Chromate transporter; Region: Chromate_transp; pfam02417 41431010344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431010345 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 41431010346 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 41431010347 ThiS interaction site; other site 41431010348 putative active site [active] 41431010349 tetramer interface [polypeptide binding]; other site 41431010350 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431010351 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 41431010352 putative C-terminal domain interface [polypeptide binding]; other site 41431010353 putative GSH binding site (G-site) [chemical binding]; other site 41431010354 putative dimer interface [polypeptide binding]; other site 41431010355 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 41431010356 dimer interface [polypeptide binding]; other site 41431010357 N-terminal domain interface [polypeptide binding]; other site 41431010358 substrate binding pocket (H-site) [chemical binding]; other site 41431010359 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 41431010360 GAF domain; Region: GAF; cl00853 41431010361 Phytochrome region; Region: PHY; pfam00360 41431010362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431010363 dimer interface [polypeptide binding]; other site 41431010364 phosphorylation site [posttranslational modification] 41431010365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431010366 ATP binding site [chemical binding]; other site 41431010367 Mg2+ binding site [ion binding]; other site 41431010368 G-X-G motif; other site 41431010369 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010371 active site 41431010372 phosphorylation site [posttranslational modification] 41431010373 intermolecular recognition site; other site 41431010374 dimerization interface [polypeptide binding]; other site 41431010375 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 41431010376 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431010377 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 41431010378 catalytic residues [active] 41431010379 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 41431010380 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 41431010381 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 41431010382 active site 41431010383 homodimer interface [polypeptide binding]; other site 41431010384 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 41431010385 replicative DNA helicase; Region: DnaB; TIGR00665 41431010386 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 41431010387 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 41431010388 Walker A motif; other site 41431010389 ATP binding site [chemical binding]; other site 41431010390 Walker B motif; other site 41431010391 DNA binding loops [nucleotide binding] 41431010392 Phd_YefM; Region: PhdYeFM; cl09153 41431010393 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431010394 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 41431010395 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 41431010396 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 41431010397 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010398 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010399 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010400 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010401 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 41431010402 active site clefts [active] 41431010403 zinc binding site [ion binding]; other site 41431010404 dimer interface [polypeptide binding]; other site 41431010405 Probable transposase; Region: OrfB_IS605; pfam01385 41431010406 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431010407 rod shape-determining protein MreD; Region: MreD; cl01087 41431010408 rod shape-determining protein MreC; Region: MreC; pfam04085 41431010409 rod shape-determining protein MreB; Provisional; Region: PRK13927 41431010410 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 41431010411 dimer interface [polypeptide binding]; other site 41431010412 ssDNA binding site [nucleotide binding]; other site 41431010413 tetramer (dimer of dimers) interface [polypeptide binding]; other site 41431010414 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 41431010415 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 41431010416 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431010417 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431010418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431010419 DNA binding residues [nucleotide binding] 41431010420 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 41431010421 IPP transferase; Region: IPPT; cl00403 41431010422 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 41431010423 metal binding site 2 [ion binding]; metal-binding site 41431010424 putative DNA binding helix; other site 41431010425 metal binding site 1 [ion binding]; metal-binding site 41431010426 dimer interface [polypeptide binding]; other site 41431010427 structural Zn2+ binding site [ion binding]; other site 41431010428 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 41431010429 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 41431010430 putative active site [active] 41431010431 catalytic triad [active] 41431010432 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 41431010433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431010434 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 41431010435 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431010436 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 41431010437 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431010438 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431010439 DNA binding residues [nucleotide binding] 41431010440 dimerization interface [polypeptide binding]; other site 41431010441 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 41431010442 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 41431010443 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 41431010444 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 41431010445 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 41431010446 NAD binding site [chemical binding]; other site 41431010447 homodimer interface [polypeptide binding]; other site 41431010448 active site 41431010449 substrate binding site [chemical binding]; other site 41431010450 PsbJ; Region: PsbJ; cl09469 41431010451 PsbL protein; Region: PsbL; cl03581 41431010452 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 41431010453 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 41431010454 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 41431010455 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 41431010456 Ycf48-like protein; Provisional; Region: PRK13684 41431010457 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 41431010458 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 41431010459 Rubredoxin; Region: Rubredoxin; pfam00301 41431010460 iron binding site [ion binding]; other site 41431010461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431010462 Helix-turn-helix domains; Region: HTH; cl00088 41431010463 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 41431010464 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 41431010465 tetramer interface [polypeptide binding]; other site 41431010466 TPP-binding site [chemical binding]; other site 41431010467 heterodimer interface [polypeptide binding]; other site 41431010468 phosphorylation loop region [posttranslational modification] 41431010469 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 41431010470 StbA protein; Region: StbA; pfam06406 41431010471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431010472 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431010473 Probable transposase; Region: OrfB_IS605; pfam01385 41431010474 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431010475 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 41431010476 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010477 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431010479 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 41431010480 GSH binding site [chemical binding]; other site 41431010481 catalytic residues [active] 41431010482 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 41431010483 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 41431010484 active site 41431010485 catalytic site [active] 41431010486 CheB methylesterase; Region: CheB_methylest; pfam01339 41431010487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 41431010488 active site 41431010489 dimerization interface [polypeptide binding]; other site 41431010490 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 41431010491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431010492 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 41431010493 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 41431010494 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 41431010495 G1 box; other site 41431010496 GTP/Mg2+ binding site [chemical binding]; other site 41431010497 Switch I region; other site 41431010498 G2 box; other site 41431010499 Switch II region; other site 41431010500 G3 box; other site 41431010501 G4 box; other site 41431010502 G5 box; other site 41431010503 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 41431010504 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 41431010505 HicB family; Region: HicB; pfam05534 41431010506 acetolactate synthase; Reviewed; Region: PRK08322 41431010507 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 41431010508 PYR/PP interface [polypeptide binding]; other site 41431010509 dimer interface [polypeptide binding]; other site 41431010510 TPP binding site [chemical binding]; other site 41431010511 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 41431010512 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 41431010513 TPP-binding site [chemical binding]; other site 41431010514 dimer interface [polypeptide binding]; other site 41431010515 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 41431010516 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 41431010517 NAD(P) binding site [chemical binding]; other site 41431010518 catalytic residues [active] 41431010519 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 41431010520 Secretin and TonB N terminus short domain; Region: STN; cl06624 41431010521 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 41431010522 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 41431010523 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 41431010524 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 41431010525 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 41431010526 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 41431010527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 41431010528 Protein kinase domain; Region: Pkinase; pfam00069 41431010529 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431010530 active site 41431010531 ATP binding site [chemical binding]; other site 41431010532 substrate binding site [chemical binding]; other site 41431010533 activation loop (A-loop); other site 41431010534 amidophosphoribosyltransferase; Provisional; Region: PRK07349 41431010535 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 41431010536 active site 41431010537 tetramer interface [polypeptide binding]; other site 41431010538 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431010539 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 41431010540 DNA polymerase III subunit delta; Validated; Region: PRK07452 41431010541 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 41431010542 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 41431010543 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 41431010544 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 41431010545 active site 41431010546 dimer interface [polypeptide binding]; other site 41431010547 metal binding site [ion binding]; metal-binding site 41431010548 S-layer homology domain; Region: SLH; pfam00395 41431010549 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 41431010550 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 41431010551 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431010552 Ligand Binding Site [chemical binding]; other site 41431010553 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 41431010554 MoaE interaction surface [polypeptide binding]; other site 41431010555 MoeB interaction surface [polypeptide binding]; other site 41431010556 thiocarboxylated glycine; other site 41431010557 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 41431010558 NADPH bind site [chemical binding]; other site 41431010559 putative FMN binding site [chemical binding]; other site 41431010560 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 41431010561 putative FMN binding site [chemical binding]; other site 41431010562 NADPH bind site [chemical binding]; other site 41431010563 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431010564 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 41431010565 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 41431010566 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431010567 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 41431010568 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 41431010569 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 41431010570 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 41431010571 Protein of unknown function (DUF1626); Region: DUF1626; pfam07788 41431010572 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 41431010573 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 41431010574 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 41431010575 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 41431010576 Phytase; Region: Phytase; pfam02333 41431010577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431010578 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431010579 Probable transposase; Region: OrfB_IS605; pfam01385 41431010580 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431010581 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 41431010582 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 41431010583 G1 box; other site 41431010584 putative GEF interaction site [polypeptide binding]; other site 41431010585 GTP/Mg2+ binding site [chemical binding]; other site 41431010586 Switch I region; other site 41431010587 G2 box; other site 41431010588 G3 box; other site 41431010589 Switch II region; other site 41431010590 G4 box; other site 41431010591 G5 box; other site 41431010592 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 41431010593 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 41431010594 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 41431010595 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 41431010596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431010597 Coenzyme A binding pocket [chemical binding]; other site 41431010598 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 41431010599 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431010600 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 41431010601 Switch I region; other site 41431010602 Switch II region; other site 41431010603 G3 box; other site 41431010604 G4 box; other site 41431010605 G5 box; other site 41431010606 KGK domain; Region: KGK; pfam08872 41431010607 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431010608 active site 41431010609 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 41431010610 putative acyl-acceptor binding pocket; other site 41431010611 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010612 putative active site [active] 41431010613 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 41431010614 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431010615 phosphopeptide binding site; other site 41431010616 cyclase homology domain; Region: CHD; cd07302 41431010617 nucleotidyl binding site; other site 41431010618 metal binding site [ion binding]; metal-binding site 41431010619 dimer interface [polypeptide binding]; other site 41431010620 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 41431010621 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 41431010622 active site 41431010623 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 41431010624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431010625 non-specific DNA binding site [nucleotide binding]; other site 41431010626 salt bridge; other site 41431010627 sequence-specific DNA binding site [nucleotide binding]; other site 41431010628 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 41431010629 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 41431010630 dimerization interface [polypeptide binding]; other site 41431010631 active site 41431010632 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 41431010633 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 41431010634 dimer interface [polypeptide binding]; other site 41431010635 decamer (pentamer of dimers) interface [polypeptide binding]; other site 41431010636 catalytic triad [active] 41431010637 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 41431010638 Family of unknown function (DUF490); Region: DUF490; pfam04357 41431010639 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 41431010640 active site 41431010641 intersubunit interactions; other site 41431010642 catalytic residue [active] 41431010643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431010644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010645 active site 41431010646 phosphorylation site [posttranslational modification] 41431010647 intermolecular recognition site; other site 41431010648 dimerization interface [polypeptide binding]; other site 41431010649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431010650 DNA binding site [nucleotide binding] 41431010651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431010652 dimer interface [polypeptide binding]; other site 41431010653 phosphorylation site [posttranslational modification] 41431010654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431010655 ATP binding site [chemical binding]; other site 41431010656 Mg2+ binding site [ion binding]; other site 41431010657 G-X-G motif; other site 41431010658 O-Antigen ligase; Region: Wzy_C; cl04850 41431010659 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 41431010660 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 41431010661 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 41431010662 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 41431010663 FAD binding pocket [chemical binding]; other site 41431010664 FAD binding motif [chemical binding]; other site 41431010665 phosphate binding motif [ion binding]; other site 41431010666 beta-alpha-beta structure motif; other site 41431010667 NAD binding pocket [chemical binding]; other site 41431010668 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431010669 catalytic loop [active] 41431010670 iron binding site [ion binding]; other site 41431010671 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 41431010672 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 41431010673 Walker A motif; other site 41431010674 ATP binding site [chemical binding]; other site 41431010675 Walker B motif; other site 41431010676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431010677 ATP binding site [chemical binding]; other site 41431010678 Walker B motif; other site 41431010679 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 41431010680 tetramer interface [polypeptide binding]; other site 41431010681 dimer interface [polypeptide binding]; other site 41431010682 KaiA domain; Region: KaiA; pfam07688 41431010683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 41431010684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431010685 dimer interface [polypeptide binding]; other site 41431010686 phosphorylation site [posttranslational modification] 41431010687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431010688 ATP binding site [chemical binding]; other site 41431010689 Mg2+ binding site [ion binding]; other site 41431010690 G-X-G motif; other site 41431010691 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010693 active site 41431010694 phosphorylation site [posttranslational modification] 41431010695 intermolecular recognition site; other site 41431010696 dimerization interface [polypeptide binding]; other site 41431010697 Helix-turn-helix domains; Region: HTH; cl00088 41431010698 putative DNA binding site [nucleotide binding]; other site 41431010699 putative Zn2+ binding site [ion binding]; other site 41431010700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431010701 dimer interface [polypeptide binding]; other site 41431010702 conserved gate region; other site 41431010703 putative PBP binding loops; other site 41431010704 ABC-ATPase subunit interface; other site 41431010705 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 41431010706 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431010707 active site 41431010708 metal binding site [ion binding]; metal-binding site 41431010709 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 41431010710 active site 41431010711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431010712 binding surface 41431010713 TPR motif; other site 41431010714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431010715 binding surface 41431010716 TPR motif; other site 41431010717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431010718 binding surface 41431010719 TPR motif; other site 41431010720 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 41431010721 putative catalytic residue [active] 41431010722 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 41431010723 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 41431010724 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 41431010725 DXD motif; other site 41431010726 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 41431010727 LabA_like proteins; Region: LabA_like; cd06167 41431010728 putative metal binding site [ion binding]; other site 41431010729 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 41431010730 DNA-binding site [nucleotide binding]; DNA binding site 41431010731 RNA-binding motif; other site 41431010732 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 41431010733 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431010734 Cupin domain; Region: Cupin_2; cl09118 41431010735 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 41431010736 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 41431010737 carbonic anhydrase; Provisional; Region: PRK15219 41431010738 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 41431010739 active site clefts [active] 41431010740 zinc binding site [ion binding]; other site 41431010741 dimer interface [polypeptide binding]; other site 41431010742 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 41431010743 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 41431010744 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 41431010745 Uncharacterized conserved protein [Function unknown]; Region: COG4748 41431010746 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 41431010747 cell division protein FtsZ; Validated; Region: PRK09330 41431010748 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 41431010749 nucleotide binding site [chemical binding]; other site 41431010750 SulA interaction site; other site 41431010751 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 41431010752 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 41431010753 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 41431010754 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 41431010755 C-terminal peptidase (prc); Region: prc; TIGR00225 41431010756 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 41431010757 protein binding site [polypeptide binding]; other site 41431010758 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 41431010759 Catalytic dyad [active] 41431010760 Ferritin-like domain; Region: Ferritin; pfam00210 41431010761 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 41431010762 dinuclear metal binding motif [ion binding]; other site 41431010763 Iron permease FTR1 family; Region: FTR1; cl00475 41431010764 EVE domain; Region: EVE; cl00728 41431010765 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 41431010766 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 41431010767 tetramer (dimer of dimers) interface [polypeptide binding]; other site 41431010768 active site 41431010769 dimer interface [polypeptide binding]; other site 41431010770 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 41431010771 RNA/DNA binding site [nucleotide binding]; other site 41431010772 RRM dimerization site [polypeptide binding]; other site 41431010773 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 41431010774 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 41431010775 NAD(P) binding site [chemical binding]; other site 41431010776 homotetramer interface [polypeptide binding]; other site 41431010777 homodimer interface [polypeptide binding]; other site 41431010778 active site 41431010779 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 41431010780 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 41431010781 Walker A/P-loop; other site 41431010782 ATP binding site [chemical binding]; other site 41431010783 Q-loop/lid; other site 41431010784 ABC transporter signature motif; other site 41431010785 Walker B; other site 41431010786 D-loop; other site 41431010787 H-loop/switch region; other site 41431010788 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 41431010789 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 41431010790 Walker A/P-loop; other site 41431010791 ATP binding site [chemical binding]; other site 41431010792 Q-loop/lid; other site 41431010793 ABC transporter signature motif; other site 41431010794 Walker B; other site 41431010795 D-loop; other site 41431010796 H-loop/switch region; other site 41431010797 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 41431010798 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 41431010799 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 41431010800 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 41431010801 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431010802 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 41431010803 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 41431010804 putative ADP-binding pocket [chemical binding]; other site 41431010805 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431010806 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431010807 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 41431010808 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 41431010809 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 41431010810 Walker A/P-loop; other site 41431010811 ATP binding site [chemical binding]; other site 41431010812 Q-loop/lid; other site 41431010813 ABC transporter signature motif; other site 41431010814 Walker B; other site 41431010815 D-loop; other site 41431010816 H-loop/switch region; other site 41431010817 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 41431010818 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431010819 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431010820 ligand binding site [chemical binding]; other site 41431010821 flexible hinge region; other site 41431010822 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 41431010823 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 41431010824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431010825 FeS/SAM binding site; other site 41431010826 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 41431010827 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 41431010828 ATP binding site [chemical binding]; other site 41431010829 Mg++ binding site [ion binding]; other site 41431010830 motif III; other site 41431010831 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431010832 nucleotide binding region [chemical binding]; other site 41431010833 ATP-binding site [chemical binding]; other site 41431010834 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 41431010835 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 41431010836 active site residue [active] 41431010837 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 41431010838 active site residue [active] 41431010839 putative inner membrane protein; Provisional; Region: PRK11099 41431010840 YeeE/YedE family (DUF395); Region: DUF395; cl01018 41431010841 putative inner membrane protein; Provisional; Region: PRK11099 41431010842 YeeE/YedE family (DUF395); Region: DUF395; cl01018 41431010843 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 41431010844 classical (c) SDRs; Region: SDR_c; cd05233 41431010845 NAD(P) binding site [chemical binding]; other site 41431010846 active site 41431010847 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 41431010848 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431010849 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 41431010850 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010852 active site 41431010853 phosphorylation site [posttranslational modification] 41431010854 intermolecular recognition site; other site 41431010855 dimerization interface [polypeptide binding]; other site 41431010856 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010858 active site 41431010859 phosphorylation site [posttranslational modification] 41431010860 intermolecular recognition site; other site 41431010861 dimerization interface [polypeptide binding]; other site 41431010862 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431010863 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431010864 dimerization interface [polypeptide binding]; other site 41431010865 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431010866 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 41431010867 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431010868 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431010869 putative binding surface; other site 41431010870 active site 41431010871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431010872 ATP binding site [chemical binding]; other site 41431010873 Mg2+ binding site [ion binding]; other site 41431010874 G-X-G motif; other site 41431010875 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431010876 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010878 active site 41431010879 phosphorylation site [posttranslational modification] 41431010880 intermolecular recognition site; other site 41431010881 dimerization interface [polypeptide binding]; other site 41431010882 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 41431010883 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010884 putative active site [active] 41431010885 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 41431010886 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 41431010887 active site 41431010888 substrate binding site [chemical binding]; other site 41431010889 trimer interface [polypeptide binding]; other site 41431010890 CoA binding site [chemical binding]; other site 41431010891 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 41431010892 substrate binding site; other site 41431010893 dimer interface; other site 41431010894 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431010895 cofactor binding site; other site 41431010896 DNA binding site [nucleotide binding] 41431010897 substrate interaction site [chemical binding]; other site 41431010898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431010899 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 41431010900 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 41431010901 Transposase domain (DUF772); Region: DUF772; cl12084 41431010902 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431010903 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431010904 active site 41431010905 metal binding site [ion binding]; metal-binding site 41431010906 ATP cone domain; Region: ATP-cone; pfam03477 41431010907 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 41431010908 Class I ribonucleotide reductase; Region: RNR_I; cd01679 41431010909 active site 41431010910 dimer interface [polypeptide binding]; other site 41431010911 catalytic residues [active] 41431010912 effector binding site; other site 41431010913 R2 peptide binding site; other site 41431010914 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431010915 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 41431010916 dimer interface [polypeptide binding]; other site 41431010917 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 41431010918 putative radical transfer pathway; other site 41431010919 diiron center [ion binding]; other site 41431010920 tyrosyl radical; other site 41431010921 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 41431010922 homodimer interface [polypeptide binding]; other site 41431010923 substrate-cofactor binding pocket; other site 41431010924 Aminotransferase class IV; Region: Aminotran_4; pfam01063 41431010925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431010926 catalytic residue [active] 41431010927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431010928 BT1 family; Region: BT1; pfam03092 41431010929 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431010930 active site 41431010931 NTP binding site [chemical binding]; other site 41431010932 metal binding triad [ion binding]; metal-binding site 41431010933 antibiotic binding site [chemical binding]; other site 41431010934 Cytochrome c; Region: Cytochrom_C; cl11414 41431010935 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 41431010936 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 41431010937 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431010938 ATP binding site [chemical binding]; other site 41431010939 putative Mg++ binding site [ion binding]; other site 41431010940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431010941 nucleotide binding region [chemical binding]; other site 41431010942 ATP-binding site [chemical binding]; other site 41431010943 TRCF domain; Region: TRCF; cl04088 41431010944 NC domain; Region: NC; pfam04970 41431010945 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431010946 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431010947 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431010948 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 41431010949 magnesium chelatase subunit H; Provisional; Region: PRK12493 41431010950 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431010951 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431010952 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431010953 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 41431010954 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 41431010955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431010956 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431010957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431010958 DNA binding residues [nucleotide binding] 41431010959 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 41431010960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431010961 dimer interface [polypeptide binding]; other site 41431010962 conserved gate region; other site 41431010963 putative PBP binding loops; other site 41431010964 ABC-ATPase subunit interface; other site 41431010965 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 41431010966 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 41431010967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431010968 FeS/SAM binding site; other site 41431010969 Entner-Doudoroff aldolase; Region: eda; TIGR01182 41431010970 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 41431010971 active site 41431010972 intersubunit interface [polypeptide binding]; other site 41431010973 catalytic residue [active] 41431010974 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 41431010975 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 41431010976 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 41431010977 TIR domain; Region: TIR; cl02060 41431010978 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010979 putative active site [active] 41431010980 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 41431010981 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 41431010982 active site 41431010983 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431010984 active site 41431010985 NTP binding site [chemical binding]; other site 41431010986 metal binding triad [ion binding]; metal-binding site 41431010987 antibiotic binding site [chemical binding]; other site 41431010988 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 41431010989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431010990 dimer interface [polypeptide binding]; other site 41431010991 phosphorylation site [posttranslational modification] 41431010992 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 41431010993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431010994 ATP binding site [chemical binding]; other site 41431010995 Mg2+ binding site [ion binding]; other site 41431010996 G-X-G motif; other site 41431010997 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010999 active site 41431011000 phosphorylation site [posttranslational modification] 41431011001 intermolecular recognition site; other site 41431011002 dimerization interface [polypeptide binding]; other site 41431011003 PAS fold; Region: PAS_4; pfam08448 41431011004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431011005 putative active site [active] 41431011006 heme pocket [chemical binding]; other site 41431011007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431011008 PAS fold; Region: PAS_3; pfam08447 41431011009 putative active site [active] 41431011010 heme pocket [chemical binding]; other site 41431011011 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431011012 metal binding site [ion binding]; metal-binding site 41431011013 active site 41431011014 I-site; other site 41431011015 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431011016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431011017 active site 41431011018 phosphorylation site [posttranslational modification] 41431011019 intermolecular recognition site; other site 41431011020 dimerization interface [polypeptide binding]; other site 41431011021 PAS domain S-box; Region: sensory_box; TIGR00229 41431011022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431011023 putative active site [active] 41431011024 heme pocket [chemical binding]; other site 41431011025 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431011026 metal binding site [ion binding]; metal-binding site 41431011027 active site 41431011028 I-site; other site 41431011029 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431011030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431011031 Response regulator receiver domain; Region: Response_reg; pfam00072 41431011032 active site 41431011033 phosphorylation site [posttranslational modification] 41431011034 intermolecular recognition site; other site 41431011035 dimerization interface [polypeptide binding]; other site 41431011036 PAS fold; Region: PAS_4; pfam08448 41431011037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 41431011038 PAS fold; Region: PAS_4; pfam08448 41431011039 GAF domain; Region: GAF; cl00853 41431011040 PAS domain S-box; Region: sensory_box; TIGR00229 41431011041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431011042 putative active site [active] 41431011043 heme pocket [chemical binding]; other site 41431011044 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431011045 PAS fold; Region: PAS_3; pfam08447 41431011046 putative active site [active] 41431011047 heme pocket [chemical binding]; other site 41431011048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 41431011049 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 41431011050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431011051 dimer interface [polypeptide binding]; other site 41431011052 phosphorylation site [posttranslational modification] 41431011053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431011054 ATP binding site [chemical binding]; other site 41431011055 Mg2+ binding site [ion binding]; other site 41431011056 G-X-G motif; other site 41431011057 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 41431011058 Putative cyclase; Region: Cyclase; cl00814 41431011059 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 41431011060 Phosphoglycerate kinase; Region: PGK; pfam00162 41431011061 substrate binding site [chemical binding]; other site 41431011062 hinge regions; other site 41431011063 ADP binding site [chemical binding]; other site 41431011064 catalytic site [active] 41431011065 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 41431011066 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431011067 RNA binding surface [nucleotide binding]; other site 41431011068 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 41431011069 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 41431011070 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 41431011071 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 41431011072 Substrate binding site; other site 41431011073 Mg++ binding site; other site 41431011074 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 41431011075 active site 41431011076 substrate binding site [chemical binding]; other site 41431011077 CoA binding site [chemical binding]; other site 41431011078 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 41431011079 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 41431011080 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 41431011081 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431011082 RNA binding surface [nucleotide binding]; other site 41431011083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431011084 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 41431011085 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 41431011086 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 41431011087 Mg++ binding site [ion binding]; other site 41431011088 putative catalytic motif [active] 41431011089 putative substrate binding site [chemical binding]; other site 41431011090 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 41431011091 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 41431011092 active site 41431011093 Calx-beta domain; Region: Calx-beta; cl02522 41431011094 Calx-beta domain; Region: Calx-beta; cl02522 41431011095 Calx-beta domain; Region: Calx-beta; cl02522 41431011096 Calx-beta domain; Region: Calx-beta; cl02522 41431011097 Calx-beta domain; Region: Calx-beta; cl02522 41431011098 Calx-beta domain; Region: Calx-beta; cl02522 41431011099 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 41431011100 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 41431011101 metal binding site [ion binding]; metal-binding site 41431011102 dimer interface [polypeptide binding]; other site 41431011103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431011104 S-adenosylmethionine binding site [chemical binding]; other site 41431011105 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 41431011106 oligomerization interface [polypeptide binding]; other site 41431011107 active site 41431011108 metal binding site [ion binding]; metal-binding site 41431011109 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 41431011110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431011111 S-adenosylmethionine binding site [chemical binding]; other site 41431011112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431011113 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 41431011114 RNA/DNA hybrid binding site [nucleotide binding]; other site 41431011115 active site 41431011116 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431011117 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 41431011118 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 41431011119 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 41431011120 putative active site [active] 41431011121 putative substrate binding site [chemical binding]; other site 41431011122 putative cosubstrate binding site; other site 41431011123 catalytic site [active] 41431011124 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 41431011125 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 41431011126 B12 binding site [chemical binding]; other site 41431011127 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431011128 FeS/SAM binding site; other site 41431011129 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 41431011130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431011131 ATP binding site [chemical binding]; other site 41431011132 putative Mg++ binding site [ion binding]; other site 41431011133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431011134 nucleotide binding region [chemical binding]; other site 41431011135 ATP-binding site [chemical binding]; other site 41431011136 large tegument protein UL36; Provisional; Region: PHA03246 41431011137 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 41431011138 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 41431011139 Ligand binding site; other site 41431011140 Putative Catalytic site; other site 41431011141 DXD motif; other site 41431011142 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 41431011143 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 41431011144 Ligand binding site; other site 41431011145 Putative Catalytic site; other site 41431011146 DXD motif; other site 41431011147 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 41431011148 Bacterial sugar transferase; Region: Bac_transf; cl00939 41431011149 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 41431011150 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 41431011151 ANP binding site [chemical binding]; other site 41431011152 Substrate Binding Site II [chemical binding]; other site 41431011153 Substrate Binding Site I [chemical binding]; other site 41431011154 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 41431011155 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 41431011156 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 41431011157 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431011158 putative active site [active] 41431011159 GTPase CgtA; Reviewed; Region: obgE; PRK12299 41431011160 GTP1/OBG; Region: GTP1_OBG; pfam01018 41431011161 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 41431011162 G1 box; other site 41431011163 GTP/Mg2+ binding site [chemical binding]; other site 41431011164 Switch I region; other site 41431011165 G2 box; other site 41431011166 G3 box; other site 41431011167 Switch II region; other site 41431011168 G4 box; other site 41431011169 G5 box; other site 41431011170 tellurium resistance terB-like protein; Region: terB_like; cd07177 41431011171 metal binding site [ion binding]; metal-binding site 41431011172 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 41431011173 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 41431011174 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 41431011175 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 41431011176 Walker A/P-loop; other site 41431011177 ATP binding site [chemical binding]; other site 41431011178 Q-loop/lid; other site 41431011179 ABC transporter signature motif; other site 41431011180 Walker B; other site 41431011181 D-loop; other site 41431011182 H-loop/switch region; other site 41431011183 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 41431011184 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 41431011185 Walker A/P-loop; other site 41431011186 ATP binding site [chemical binding]; other site 41431011187 Q-loop/lid; other site 41431011188 ABC transporter signature motif; other site 41431011189 Walker B; other site 41431011190 D-loop; other site 41431011191 H-loop/switch region; other site 41431011192 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431011193 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 41431011194 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 41431011195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431011196 dimer interface [polypeptide binding]; other site 41431011197 conserved gate region; other site 41431011198 putative PBP binding loops; other site 41431011199 ABC-ATPase subunit interface; other site 41431011200 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431011201 short chain dehydrogenase; Validated; Region: PRK08324 41431011202 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 41431011203 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 41431011204 putative NAD(P) binding site [chemical binding]; other site 41431011205 active site 41431011206 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 41431011207 active site 41431011208 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 41431011209 Cadmium resistance transporter; Region: Cad; cl04177 41431011210 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 41431011211 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 41431011212 Helix-turn-helix domains; Region: HTH; cl00088 41431011213 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 41431011214 putative dimerization interface [polypeptide binding]; other site 41431011215 Cadmium resistance transporter; Region: Cad; cl04177 41431011216 Domain of unknown function DUF; Region: DUF202; cl09954 41431011217 PAS fold; Region: PAS; pfam00989 41431011218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 41431011219 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 41431011220 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 41431011221 transmembrane helices; other site 41431011222 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 41431011223 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 41431011224 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 41431011225 Integral membrane protein TerC family; Region: TerC; cl10468 41431011226 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 41431011227 Cadmium resistance transporter; Region: Cad; cl04177 41431011228 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431011229 structural tetrad; other site 41431011230 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431011231 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431011232 structural tetrad; other site 41431011233 coronin; Provisional; Region: PTZ00421 41431011234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431011235 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431011236 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431011237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431011238 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431011239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431011240 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 41431011241 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 41431011242 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 41431011243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 41431011244 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 41431011245 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 41431011246 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 41431011247 shikimate binding site; other site 41431011248 NAD(P) binding site [chemical binding]; other site 41431011249 dihydroorotase; Provisional; Region: PRK07575 41431011250 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 41431011251 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 41431011252 active site 41431011253 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 41431011254 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 41431011255 Catalytic site [active] 41431011256 RNA polymerase sigma factor; Provisional; Region: PRK12518 41431011257 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431011258 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431011259 DNA binding residues [nucleotide binding] 41431011260 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 41431011261 dimer interface [polypeptide binding]; other site 41431011262 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 41431011263 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 41431011264 PAS domain S-box; Region: sensory_box; TIGR00229 41431011265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431011266 putative active site [active] 41431011267 heme pocket [chemical binding]; other site 41431011268 PAS domain S-box; Region: sensory_box; TIGR00229 41431011269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431011270 putative active site [active] 41431011271 heme pocket [chemical binding]; other site 41431011272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 41431011273 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 41431011274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431011275 putative active site [active] 41431011276 heme pocket [chemical binding]; other site 41431011277 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 41431011278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431011279 metal binding site [ion binding]; metal-binding site 41431011280 active site 41431011281 I-site; other site 41431011282 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431011283 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 41431011284 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 41431011285 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 41431011286 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 41431011287 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 41431011288 Protein of unknown function (DUF541); Region: SIMPL; cl01077 41431011289 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 41431011290 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431011291 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431011292 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 41431011293 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431011294 putative active site [active] 41431011295 putative metal binding site [ion binding]; other site 41431011296 YGGT family; Region: YGGT; cl00508 41431011297 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 41431011298 dimer interface [polypeptide binding]; other site 41431011299 catalytic triad [active] 41431011300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431011301 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431011302 Probable transposase; Region: OrfB_IS605; pfam01385 41431011303 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431011304 LemA family; Region: LemA; cl00742 41431011305 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 41431011306 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 41431011307 Ligand binding site; other site 41431011308 Putative Catalytic site; other site 41431011309 DXD motif; other site 41431011310 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 41431011311 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 41431011312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 41431011313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 41431011314 Family of unknown function (DUF490); Region: DUF490; pfam04357 41431011315 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 41431011316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431011317 substrate binding pocket [chemical binding]; other site 41431011318 membrane-bound complex binding site; other site 41431011319 hinge residues; other site 41431011320 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 41431011321 Stage II sporulation protein; Region: SpoIID; pfam08486 41431011322 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 41431011323 active site 41431011324 catalytic triad [active] 41431011325 oxyanion hole [active] 41431011326 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 41431011327 active site 41431011328 catalytic residues [active] 41431011329 metal binding site [ion binding]; metal-binding site 41431011330 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 41431011331 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 41431011332 RHS Repeat; Region: RHS_repeat; cl11982 41431011333 RHS Repeat; Region: RHS_repeat; cl11982 41431011334 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 41431011335 RHS Repeat; Region: RHS_repeat; cl11982 41431011336 RHS Repeat; Region: RHS_repeat; cl11982 41431011337 RHS Repeat; Region: RHS_repeat; cl11982 41431011338 RHS Repeat; Region: RHS_repeat; cl11982 41431011339 RHS Repeat; Region: RHS_repeat; cl11982 41431011340 RHS Repeat; Region: RHS_repeat; cl11982 41431011341 RHS Repeat; Region: RHS_repeat; cl11982 41431011342 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 41431011343 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 41431011344 Int/Topo IB signature motif; other site 41431011345 active site 41431011346 DNA binding site [nucleotide binding] 41431011347 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 41431011348 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 41431011349 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 41431011350 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 41431011351 active site 41431011352 metal binding site [ion binding]; metal-binding site