-- dump date 20120504_143119 -- class Genbank::misc_feature -- table misc_feature_note -- id note 395962000001 Protein of unknown function (DUF497); Region: DUF497; cl01108 395962000002 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 395962000003 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395962000004 Helix-turn-helix domains; Region: HTH; cl00088 395962000005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395962000006 Helix-turn-helix domains; Region: HTH; cl00088 395962000007 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 395962000008 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 395962000009 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395962000010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395962000011 P-loop; other site 395962000012 Magnesium ion binding site [ion binding]; other site 395962000013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962000014 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 395962000015 Transposase domain (DUF772); Region: DUF772; cl15789 395962000016 Transposase domain (DUF772); Region: DUF772; cl15789 395962000017 Spindle-body formation-associated protein; Region: Cut12; pfam11500 395962000018 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 395962000019 Spindle-body formation-associated protein; Region: Cut12; pfam11500 395962000020 Transposase; Region: HTH_Tnp_IS630; pfam01710 395962000021 Integrase core domain; Region: rve; cl01316 395962000022 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 395962000023 DNA primase, catalytic core; Region: dnaG; TIGR01391 395962000024 CHC2 zinc finger; Region: zf-CHC2; cl15369 395962000025 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 395962000026 Phage associated DNA primase [General function prediction only]; Region: COG3378 395962000027 D5 N terminal like; Region: D5_N; cl07360 395962000028 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 395962000029 Helix-turn-helix domains; Region: HTH; cl00088 395962000030 Winged helix-turn helix; Region: HTH_29; pfam13551 395962000031 Helix-turn-helix domains; Region: HTH; cl00088 395962000032 Integrase core domain; Region: rve; cl01316 395962000033 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 395962000034 Helix-turn-helix domains; Region: HTH; cl00088 395962000035 Winged helix-turn helix; Region: HTH_29; pfam13551 395962000036 Winged helix-turn helix; Region: HTH_33; pfam13592 395962000037 DDE superfamily endonuclease; Region: DDE_5; cl02413 395962000038 DDE superfamily endonuclease; Region: DDE_5; cl02413 395962000039 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 395962000040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395962000041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395962000042 DNA binding residues [nucleotide binding] 395962000043 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 395962000044 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 395962000045 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962000046 dimerization interface [polypeptide binding]; other site 395962000047 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 395962000048 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962000049 putative active site [active] 395962000050 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 395962000051 Transposase domain (DUF772); Region: DUF772; cl15789 395962000052 Transposase domain (DUF772); Region: DUF772; cl15789 395962000053 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 395962000054 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 395962000055 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 395962000056 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 395962000057 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962000058 WYL domain; Region: WYL; cl14852 395962000059 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 395962000060 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 395962000061 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 395962000062 generic binding surface II; other site 395962000063 generic binding surface I; other site 395962000064 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395962000065 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 395962000066 DNA binding site [nucleotide binding] 395962000067 Int/Topo IB signature motif; other site 395962000068 active site 395962000069 DDE superfamily endonuclease; Region: DDE_5; cl02413 395962000070 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962000071 carotene isomerase; Region: carot_isom; TIGR02730 395962000072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000074 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 395962000075 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395962000076 active site 395962000077 catalytic tetrad [active] 395962000078 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 395962000079 DnaA N-terminal domain; Region: DnaA_N; pfam11638 395962000080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962000081 Walker A motif; other site 395962000082 ATP binding site [chemical binding]; other site 395962000083 Walker B motif; other site 395962000084 arginine finger; other site 395962000085 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 395962000086 DnaA box-binding interface [nucleotide binding]; other site 395962000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962000088 phosphopeptide binding site; other site 395962000089 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962000090 metal binding site [ion binding]; metal-binding site 395962000091 active site 395962000092 I-site; other site 395962000093 Phospholipid methyltransferase; Region: PEMT; cl00763 395962000094 Domain of unknown function (DUF427); Region: DUF427; cl00998 395962000095 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 395962000096 Clp amino terminal domain; Region: Clp_N; pfam02861 395962000097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962000098 Walker A motif; other site 395962000099 ATP binding site [chemical binding]; other site 395962000100 Walker B motif; other site 395962000101 arginine finger; other site 395962000102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962000103 Walker A motif; other site 395962000104 ATP binding site [chemical binding]; other site 395962000105 Walker B motif; other site 395962000106 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 395962000107 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962000108 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 395962000109 Ligand binding site; other site 395962000110 Putative Catalytic site; other site 395962000111 DXD motif; other site 395962000112 UbiA prenyltransferase family; Region: UbiA; cl00337 395962000113 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 395962000114 nickel binding site [ion binding]; other site 395962000115 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962000116 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 395962000117 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 395962000118 Protein of unknown function (DUF1390); Region: DUF1390; pfam07150 395962000119 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395962000120 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 395962000121 active site 395962000122 catalytic tetrad [active] 395962000123 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 395962000124 RuvA N terminal domain; Region: RuvA_N; pfam01330 395962000125 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 395962000126 Protein kinase C-related kinase homology region 1 domain; also known as the ACC (antiparallel coiled-coil) finger domain or Rho-binding domain. Found in vertebrate PRK1 and yeast PKC1 protein kinases C; those found in rhophilin bind RhoGTP; those in PRK1...; Region: HR1; cl00087 395962000127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395962000128 PAS fold; Region: PAS_3; pfam08447 395962000129 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962000130 GAF domain; Region: GAF; cl15785 395962000131 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962000132 metal binding site [ion binding]; metal-binding site 395962000133 active site 395962000134 I-site; other site 395962000135 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 395962000136 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 395962000137 substrate binding site [chemical binding]; other site 395962000138 ATP binding site [chemical binding]; other site 395962000139 Predicted methyltransferases [General function prediction only]; Region: COG0313 395962000140 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 395962000141 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962000142 putative active site [active] 395962000143 Clp protease ATP binding subunit; Region: clpC; CHL00095 395962000144 Clp amino terminal domain; Region: Clp_N; pfam02861 395962000145 Clp amino terminal domain; Region: Clp_N; pfam02861 395962000146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962000147 Walker A motif; other site 395962000148 ATP binding site [chemical binding]; other site 395962000149 Walker B motif; other site 395962000150 arginine finger; other site 395962000151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962000152 Walker A motif; other site 395962000153 ATP binding site [chemical binding]; other site 395962000154 Walker B motif; other site 395962000155 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 395962000156 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962000157 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962000158 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395962000159 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 395962000160 active site 395962000161 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962000162 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 395962000163 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 395962000164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395962000165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395962000166 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395962000167 catalytic residues [active] 395962000168 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 395962000169 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 395962000170 Panthothenate kinase [Coenzyme metabolism]; Region: CoaA; COG1072 395962000171 enoyl-CoA hydratase; Provisional; Region: PRK06190 395962000172 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 395962000173 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 395962000174 metal binding site [ion binding]; metal-binding site 395962000175 dimer interface [polypeptide binding]; other site 395962000176 Flavin Reductases; Region: FlaRed; cl00801 395962000177 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 395962000178 transmembrane helices; other site 395962000179 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 395962000180 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 395962000181 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 395962000182 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 395962000183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962000184 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962000185 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 395962000186 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 395962000187 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 395962000188 NAD binding site [chemical binding]; other site 395962000189 homodimer interface [polypeptide binding]; other site 395962000190 active site 395962000191 substrate binding site [chemical binding]; other site 395962000192 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395962000193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962000194 active site 395962000195 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962000196 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962000197 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962000198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000199 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395962000200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962000201 active site 395962000202 Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364 395962000203 Putative cyclase; Region: Cyclase; cl00814 395962000204 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 395962000205 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962000206 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 395962000207 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 395962000208 classical (c) SDRs; Region: SDR_c; cd05233 395962000209 NAD(P) binding site [chemical binding]; other site 395962000210 active site 395962000211 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 395962000212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000213 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 395962000214 ligand binding site; other site 395962000215 tetramer interface; other site 395962000216 Photosystem II protein; Region: PSII; cl08223 395962000217 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 395962000218 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 395962000219 D1 interface; other site 395962000220 chlorophyll binding site; other site 395962000221 pheophytin binding site; other site 395962000222 beta carotene binding site; other site 395962000223 cytochrome b559 beta interface; other site 395962000224 quinone binding site; other site 395962000225 cytochrome b559 alpha interface; other site 395962000226 protein J interface; other site 395962000227 protein H interface; other site 395962000228 protein X interface; other site 395962000229 core light harvesting protein interface; other site 395962000230 protein L interface; other site 395962000231 CP43 interface; other site 395962000232 protein T interface; other site 395962000233 Fe binding site [ion binding]; other site 395962000234 protein M interface; other site 395962000235 Mn-stabilizing polypeptide interface; other site 395962000236 bromide binding site; other site 395962000237 cytochrome c-550 interface; other site 395962000238 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962000239 putative active site [active] 395962000240 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 395962000241 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 395962000242 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 395962000243 Walker A/P-loop; other site 395962000244 ATP binding site [chemical binding]; other site 395962000245 Q-loop/lid; other site 395962000246 ABC transporter signature motif; other site 395962000247 Walker B; other site 395962000248 D-loop; other site 395962000249 H-loop/switch region; other site 395962000250 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 395962000251 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 395962000252 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 395962000253 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 395962000254 Ycf39; Provisional; Region: ycf39; CHL00194 395962000255 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 395962000256 NAD(P) binding site [chemical binding]; other site 395962000257 putative active site [active] 395962000258 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 395962000259 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 395962000260 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 395962000261 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 395962000262 substrate-cofactor binding pocket; other site 395962000263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962000264 catalytic residue [active] 395962000265 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 395962000266 proline aminopeptidase P II; Provisional; Region: PRK10879 395962000267 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 395962000268 active site 395962000269 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 395962000270 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 395962000271 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 395962000272 Peptidase family M48; Region: Peptidase_M48; cl12018 395962000273 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 395962000274 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 395962000275 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395962000276 Zn2+ binding site [ion binding]; other site 395962000277 Mg2+ binding site [ion binding]; other site 395962000278 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 395962000279 Bacterial SH3 domain; Region: SH3_3; cl02551 395962000280 Bacterial SH3 domain; Region: SH3_3; cl02551 395962000281 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962000282 putative active site [active] 395962000283 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 395962000284 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 395962000285 Mg++ binding site [ion binding]; other site 395962000286 putative catalytic motif [active] 395962000287 substrate binding site [chemical binding]; other site 395962000288 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 395962000289 Protein of unknown function, DUF393; Region: DUF393; cl01136 395962000290 Cupin domain; Region: Cupin_2; cl09118 395962000291 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 395962000292 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395962000293 inhibitor-cofactor binding pocket; inhibition site 395962000294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962000295 catalytic residue [active] 395962000296 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 395962000297 DNA binding residues [nucleotide binding] 395962000298 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 395962000299 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 395962000300 cofactor binding site; other site 395962000301 DNA binding site [nucleotide binding] 395962000302 substrate interaction site [chemical binding]; other site 395962000303 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 395962000304 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 395962000305 putative substrate binding site [chemical binding]; other site 395962000306 putative ATP binding site [chemical binding]; other site 395962000307 EVE domain; Region: EVE; cl00728 395962000308 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 395962000309 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 395962000310 putative active site [active] 395962000311 metal binding site [ion binding]; metal-binding site 395962000312 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962000313 putative active site [active] 395962000314 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395962000315 Ligand Binding Site [chemical binding]; other site 395962000316 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 395962000317 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 395962000318 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 395962000319 putative active site pocket [active] 395962000320 4-fold oligomerization interface [polypeptide binding]; other site 395962000321 metal binding residues [ion binding]; metal-binding site 395962000322 3-fold/trimer interface [polypeptide binding]; other site 395962000323 Double zinc ribbon; Region: DZR; pfam12773 395962000324 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 395962000325 active site 395962000326 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 395962000327 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 395962000328 NADP binding site [chemical binding]; other site 395962000329 active site 395962000330 putative substrate binding site [chemical binding]; other site 395962000331 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 395962000332 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 395962000333 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 395962000334 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 395962000335 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 395962000336 4Fe-4S binding domain; Region: Fer4; cl02805 395962000337 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 395962000338 dimer interface [polypeptide binding]; other site 395962000339 [2Fe-2S] cluster binding site [ion binding]; other site 395962000340 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 395962000341 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 395962000342 SLBB domain; Region: SLBB; pfam10531 395962000343 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 395962000344 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 395962000345 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 395962000346 putative dimer interface [polypeptide binding]; other site 395962000347 [2Fe-2S] cluster binding site [ion binding]; other site 395962000348 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962000349 putative active site [active] 395962000350 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 395962000351 heme binding pocket [chemical binding]; other site 395962000352 heme ligand [chemical binding]; other site 395962000353 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 395962000354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962000355 FeS/SAM binding site; other site 395962000356 HemN C-terminal domain; Region: HemN_C; pfam06969 395962000357 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 395962000358 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 395962000359 FMN binding site [chemical binding]; other site 395962000360 active site 395962000361 substrate binding site [chemical binding]; other site 395962000362 catalytic residue [active] 395962000363 Cupin domain; Region: Cupin_2; cl09118 395962000364 Helix-turn-helix domains; Region: HTH; cl00088 395962000365 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 395962000366 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 395962000367 dimer interface [polypeptide binding]; other site 395962000368 FMN binding site [chemical binding]; other site 395962000369 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395962000370 HSP70 interaction site [polypeptide binding]; other site 395962000371 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962000372 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962000373 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962000374 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 395962000375 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 395962000376 Proline dehydrogenase; Region: Pro_dh; cl03282 395962000377 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 395962000378 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 395962000379 Glutamate binding site [chemical binding]; other site 395962000380 homodimer interface [polypeptide binding]; other site 395962000381 NAD binding site [chemical binding]; other site 395962000382 catalytic residues [active] 395962000383 GTP-binding protein Der; Reviewed; Region: PRK00093 395962000384 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 395962000385 G1 box; other site 395962000386 GTP/Mg2+ binding site [chemical binding]; other site 395962000387 Switch I region; other site 395962000388 G2 box; other site 395962000389 Switch II region; other site 395962000390 G3 box; other site 395962000391 G4 box; other site 395962000392 G5 box; other site 395962000393 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 395962000394 G1 box; other site 395962000395 GTP/Mg2+ binding site [chemical binding]; other site 395962000396 Switch I region; other site 395962000397 G2 box; other site 395962000398 G3 box; other site 395962000399 Switch II region; other site 395962000400 G4 box; other site 395962000401 G5 box; other site 395962000402 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962000403 putative active site [active] 395962000404 Peptidase family M48; Region: Peptidase_M48; cl12018 395962000405 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 395962000406 active site 395962000407 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962000408 active site 395962000409 ATP binding site [chemical binding]; other site 395962000410 substrate binding site [chemical binding]; other site 395962000411 activation loop (A-loop); other site 395962000412 diaminopimelate decarboxylase; Region: lysA; TIGR01048 395962000413 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 395962000414 active site 395962000415 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395962000416 substrate binding site [chemical binding]; other site 395962000417 catalytic residues [active] 395962000418 dimer interface [polypeptide binding]; other site 395962000419 TIGR00159 family protein; Region: TIGR00159 395962000420 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 395962000421 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 395962000422 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 395962000423 catalytic residue [active] 395962000424 putative FPP diphosphate binding site; other site 395962000425 putative FPP binding hydrophobic cleft; other site 395962000426 dimer interface [polypeptide binding]; other site 395962000427 putative IPP diphosphate binding site; other site 395962000428 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 395962000429 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 395962000430 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 395962000431 DNA binding site [nucleotide binding] 395962000432 catalytic residue [active] 395962000433 H2TH interface [polypeptide binding]; other site 395962000434 putative catalytic residues [active] 395962000435 turnover-facilitating residue; other site 395962000436 intercalation triad [nucleotide binding]; other site 395962000437 8OG recognition residue [nucleotide binding]; other site 395962000438 putative reading head residues; other site 395962000439 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 395962000440 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 395962000441 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 395962000442 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 395962000443 proline aminopeptidase P II; Provisional; Region: PRK10879 395962000444 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 395962000445 active site 395962000446 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 395962000447 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395962000448 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 395962000449 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 395962000450 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 395962000451 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 395962000452 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 395962000453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000454 NAD(P) binding site [chemical binding]; other site 395962000455 active site 395962000456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962000457 TPR motif; other site 395962000458 binding surface 395962000459 TPR repeat; Region: TPR_11; pfam13414 395962000460 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 395962000461 lipoprotein signal peptidase; Provisional; Region: PRK14787 395962000462 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 395962000463 hypothetical protein; Provisional; Region: PRK05926 395962000464 biotin synthase; Region: bioB; TIGR00433 395962000465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962000466 FeS/SAM binding site; other site 395962000467 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 395962000468 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 395962000469 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 395962000470 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962000471 XisI protein; Region: XisI; pfam08869 395962000472 XisH protein; Region: XisH; pfam08814 395962000473 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962000474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962000475 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962000476 Probable transposase; Region: OrfB_IS605; pfam01385 395962000477 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962000478 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 395962000479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395962000480 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 395962000481 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395962000482 DNA binding residues [nucleotide binding] 395962000483 Divergent PAP2 family; Region: DUF212; cl00855 395962000484 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 395962000485 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 395962000486 substrate binding pocket [chemical binding]; other site 395962000487 chain length determination region; other site 395962000488 substrate-Mg2+ binding site; other site 395962000489 catalytic residues [active] 395962000490 aspartate-rich region 1; other site 395962000491 active site lid residues [active] 395962000492 aspartate-rich region 2; other site 395962000493 Frequency clock protein; Region: FRQ; pfam09421 395962000494 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 395962000495 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962000496 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 395962000497 active site 395962000498 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 395962000499 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 395962000500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962000501 Coenzyme A binding pocket [chemical binding]; other site 395962000502 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 395962000503 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 395962000504 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395962000505 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 395962000506 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395962000507 DNA binding residues [nucleotide binding] 395962000508 primosome assembly protein PriA; Validated; Region: PRK05580 395962000509 primosome assembly protein PriA; Validated; Region: PRK05580 395962000510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962000511 ATP binding site [chemical binding]; other site 395962000512 putative Mg++ binding site [ion binding]; other site 395962000513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962000514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962000515 Coenzyme A binding pocket [chemical binding]; other site 395962000516 putative acetyltransferase; Provisional; Region: PRK03624 395962000517 Protein of unknown function (DUF433); Region: DUF433; cl01030 395962000518 YcfA-like protein; Region: YcfA; cl00752 395962000519 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962000520 GAF domain; Region: GAF_2; pfam13185 395962000521 GAF domain; Region: GAF; cl15785 395962000522 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962000523 geranylgeranyl diphosphate reductase; Provisional; Region: PLN00093 395962000524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000526 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 395962000527 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962000528 Circadian oscillating protein COP23; Region: COP23; pfam14218 395962000529 CpeS-like protein; Region: CpeS; pfam09367 395962000530 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 395962000531 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 395962000532 GTP binding site; other site 395962000533 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 395962000534 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 395962000535 Ligand Binding Site [chemical binding]; other site 395962000536 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 395962000537 apolar tunnel; other site 395962000538 heme binding site [chemical binding]; other site 395962000539 dimerization interface [polypeptide binding]; other site 395962000540 Peptidase family M48; Region: Peptidase_M48; cl12018 395962000541 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 395962000542 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 395962000543 putative active site [active] 395962000544 putative FMN binding site [chemical binding]; other site 395962000545 putative substrate binding site [chemical binding]; other site 395962000546 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 395962000547 active site 395962000548 ADP/pyrophosphate binding site [chemical binding]; other site 395962000549 dimerization interface [polypeptide binding]; other site 395962000550 allosteric effector site; other site 395962000551 fructose-1,6-bisphosphate binding site; other site 395962000552 ABC-2 type transporter; Region: ABC2_membrane; cl11417 395962000553 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 395962000554 catalytic site [active] 395962000555 G-X2-G-X-G-K; other site 395962000556 Domain of unknown function (DUF370); Region: DUF370; cl00898 395962000557 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962000558 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962000559 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 395962000560 [2Fe-2S] cluster binding site [ion binding]; other site 395962000561 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 395962000562 putative alpha subunit interface [polypeptide binding]; other site 395962000563 putative active site [active] 395962000564 putative substrate binding site [chemical binding]; other site 395962000565 Fe binding site [ion binding]; other site 395962000566 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 395962000567 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 395962000568 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 395962000569 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 395962000570 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 395962000571 Catalytic site [active] 395962000572 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 395962000573 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 395962000574 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 395962000575 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 395962000576 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 395962000577 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 395962000578 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 395962000579 NAD binding site [chemical binding]; other site 395962000580 dimerization interface [polypeptide binding]; other site 395962000581 product binding site; other site 395962000582 substrate binding site [chemical binding]; other site 395962000583 zinc binding site [ion binding]; other site 395962000584 catalytic residues [active] 395962000585 Fic family protein [Function unknown]; Region: COG3177 395962000586 Fic/DOC family; Region: Fic; cl00960 395962000587 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 395962000588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395962000589 active site 395962000590 catalytic tetrad [active] 395962000591 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 395962000592 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395962000593 peptide chain release factor 1; Validated; Region: prfA; PRK00591 395962000594 RF-1 domain; Region: RF-1; cl02875 395962000595 RF-1 domain; Region: RF-1; cl02875 395962000596 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 395962000597 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395962000598 dimer interface [polypeptide binding]; other site 395962000599 putative metal binding site [ion binding]; other site 395962000600 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962000601 YcfA-like protein; Region: YcfA; cl00752 395962000602 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 395962000603 Transposase domain (DUF772); Region: DUF772; cl15789 395962000604 Tetratricopeptide repeat; Region: TPR_10; pfam13374 395962000605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962000606 TPR motif; other site 395962000607 TPR repeat; Region: TPR_11; pfam13414 395962000608 binding surface 395962000609 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962000610 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962000611 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962000612 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 395962000613 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 395962000614 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 395962000615 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962000616 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 395962000617 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 395962000618 substrate binding site [chemical binding]; other site 395962000619 ligand binding site [chemical binding]; other site 395962000620 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 395962000621 Protein of unknown function, DUF486; Region: DUF486; cl01236 395962000622 Transglycosylase; Region: Transgly; cl07896 395962000623 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 395962000624 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962000625 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 395962000626 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 395962000627 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 395962000628 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 395962000629 23S rRNA interface [nucleotide binding]; other site 395962000630 L3 interface [polypeptide binding]; other site 395962000631 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 395962000632 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 395962000633 dimerization interface 3.5A [polypeptide binding]; other site 395962000634 active site 395962000635 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 395962000636 RNA polymerase alpha subunit; Region: rpoA; CHL00013 395962000637 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 395962000638 alphaNTD homodimer interface [polypeptide binding]; other site 395962000639 alphaNTD - beta interaction site [polypeptide binding]; other site 395962000640 alphaNTD - beta' interaction site [polypeptide binding]; other site 395962000641 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 395962000642 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 395962000643 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 395962000644 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 395962000645 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 395962000646 rRNA binding site [nucleotide binding]; other site 395962000647 predicted 30S ribosome binding site; other site 395962000648 adenylate kinase; Provisional; Region: adk; PRK02496 395962000649 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 395962000650 AMP-binding site [chemical binding]; other site 395962000651 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 395962000652 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 395962000653 SecY translocase; Region: SecY; pfam00344 395962000654 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 395962000655 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 395962000656 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 395962000657 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 395962000658 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 395962000659 23S rRNA interface [nucleotide binding]; other site 395962000660 L21e interface [polypeptide binding]; other site 395962000661 5S rRNA interface [nucleotide binding]; other site 395962000662 L27 interface [polypeptide binding]; other site 395962000663 L5 interface [polypeptide binding]; other site 395962000664 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 395962000665 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 395962000666 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 395962000667 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 395962000668 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 395962000669 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 395962000670 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 395962000671 KOW motif; Region: KOW; cl00354 395962000672 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 395962000673 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 395962000674 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 395962000675 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 395962000676 putative translocon interaction site; other site 395962000677 23S rRNA interface [nucleotide binding]; other site 395962000678 signal recognition particle (SRP54) interaction site; other site 395962000679 L23 interface [polypeptide binding]; other site 395962000680 trigger factor interaction site; other site 395962000681 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 395962000682 23S rRNA interface [nucleotide binding]; other site 395962000683 5S rRNA interface [nucleotide binding]; other site 395962000684 putative antibiotic binding site [chemical binding]; other site 395962000685 L25 interface [polypeptide binding]; other site 395962000686 L27 interface [polypeptide binding]; other site 395962000687 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 395962000688 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 395962000689 G-X-X-G motif; other site 395962000690 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 395962000691 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 395962000692 putative translocon binding site; other site 395962000693 protein-rRNA interface [nucleotide binding]; other site 395962000694 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 395962000695 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 395962000696 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 395962000697 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 395962000698 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 395962000699 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 395962000700 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 395962000701 DDE superfamily endonuclease; Region: DDE_5; cl02413 395962000702 DDE superfamily endonuclease; Region: DDE_5; cl02413 395962000703 UbiA prenyltransferase family; Region: UbiA; cl00337 395962000704 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 395962000705 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 395962000706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395962000707 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 395962000708 substrate binding site [chemical binding]; other site 395962000709 oxyanion hole (OAH) forming residues; other site 395962000710 trimer interface [polypeptide binding]; other site 395962000711 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 395962000712 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 395962000713 RNase E interface [polypeptide binding]; other site 395962000714 trimer interface [polypeptide binding]; other site 395962000715 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 395962000716 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 395962000717 RNase E interface [polypeptide binding]; other site 395962000718 trimer interface [polypeptide binding]; other site 395962000719 active site 395962000720 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 395962000721 putative nucleic acid binding region [nucleotide binding]; other site 395962000722 G-X-X-G motif; other site 395962000723 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 395962000724 RNA binding site [nucleotide binding]; other site 395962000725 domain interface; other site 395962000726 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 395962000727 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 395962000728 putative catalytic site [active] 395962000729 putative metal binding site [ion binding]; other site 395962000730 putative phosphate binding site [ion binding]; other site 395962000731 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 395962000732 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 395962000733 Active Sites [active] 395962000734 Predicted permeases [General function prediction only]; Region: COG0701 395962000735 Predicted permease; Region: DUF318; pfam03773 395962000736 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 395962000737 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 395962000738 metal ion-dependent adhesion site (MIDAS); other site 395962000739 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 395962000740 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 395962000741 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 395962000742 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395962000743 catalytic core [active] 395962000744 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962000745 putative active site [active] 395962000746 NAD synthetase; Provisional; Region: PRK13981 395962000747 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 395962000748 multimer interface [polypeptide binding]; other site 395962000749 active site 395962000750 catalytic triad [active] 395962000751 protein interface 1 [polypeptide binding]; other site 395962000752 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 395962000753 homodimer interface [polypeptide binding]; other site 395962000754 NAD binding pocket [chemical binding]; other site 395962000755 ATP binding pocket [chemical binding]; other site 395962000756 Mg binding site [ion binding]; other site 395962000757 active-site loop [active] 395962000758 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 395962000759 nudix motif; other site 395962000760 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 395962000761 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 395962000762 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 395962000763 active site 395962000764 (T/H)XGH motif; other site 395962000765 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 395962000766 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 395962000767 active site 395962000768 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 395962000769 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 395962000770 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 395962000771 HflX GTPase family; Region: HflX; cd01878 395962000772 G1 box; other site 395962000773 GTP/Mg2+ binding site [chemical binding]; other site 395962000774 Switch I region; other site 395962000775 G2 box; other site 395962000776 G3 box; other site 395962000777 Switch II region; other site 395962000778 G4 box; other site 395962000779 G5 box; other site 395962000780 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 395962000781 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962000782 dimerization interface [polypeptide binding]; other site 395962000783 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 395962000784 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 395962000785 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395962000786 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395962000787 FtsH Extracellular; Region: FtsH_ext; pfam06480 395962000788 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 395962000789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962000790 Walker A motif; other site 395962000791 ATP binding site [chemical binding]; other site 395962000792 Walker B motif; other site 395962000793 arginine finger; other site 395962000794 Peptidase family M41; Region: Peptidase_M41; pfam01434 395962000795 transcriptional regulator; Provisional; Region: PRK10632 395962000796 Helix-turn-helix domains; Region: HTH; cl00088 395962000797 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 395962000798 putative effector binding pocket; other site 395962000799 dimerization interface [polypeptide binding]; other site 395962000800 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 395962000801 Surface antigen; Region: Bac_surface_Ag; cl03097 395962000802 haemagglutination activity domain; Region: Haemagg_act; cl05436 395962000803 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 395962000804 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 395962000805 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 395962000806 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395962000807 active site 395962000808 catalytic tetrad [active] 395962000809 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962000810 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962000811 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962000812 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962000813 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962000814 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 395962000815 SNF2 Helicase protein; Region: DUF3670; pfam12419 395962000816 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962000817 ATP binding site [chemical binding]; other site 395962000818 putative Mg++ binding site [ion binding]; other site 395962000819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395962000820 nucleotide binding region [chemical binding]; other site 395962000821 ATP-binding site [chemical binding]; other site 395962000822 conserved hypothetical protein; Region: TIGR03492 395962000823 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962000824 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 395962000825 ligand binding site; other site 395962000826 tetramer interface; other site 395962000827 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 395962000828 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 395962000829 Walker A/P-loop; other site 395962000830 ATP binding site [chemical binding]; other site 395962000831 Q-loop/lid; other site 395962000832 ABC transporter signature motif; other site 395962000833 Walker B; other site 395962000834 D-loop; other site 395962000835 H-loop/switch region; other site 395962000836 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 395962000837 putative carbohydrate binding site [chemical binding]; other site 395962000838 Family description; Region: VCBS; pfam13517 395962000839 Family description; Region: VCBS; pfam13517 395962000840 Family description; Region: VCBS; pfam13517 395962000841 Family description; Region: VCBS; pfam13517 395962000842 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 395962000843 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 395962000844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000846 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 395962000847 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 395962000848 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 395962000849 Active_site [active] 395962000850 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 395962000851 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962000852 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395962000853 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962000854 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962000855 Helix-turn-helix domains; Region: HTH; cl00088 395962000856 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 395962000857 4Fe-4S binding domain; Region: Fer4_5; pfam12801 395962000858 4Fe-4S binding domain; Region: Fer4_5; pfam12801 395962000859 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395962000860 ligand binding site [chemical binding]; other site 395962000861 flexible hinge region; other site 395962000862 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962000863 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962000864 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962000865 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962000866 AAA domain; Region: AAA_21; pfam13304 395962000867 Walker A/P-loop; other site 395962000868 ATP binding site [chemical binding]; other site 395962000869 Predicted ATPase [General function prediction only]; Region: COG4637 395962000870 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962000871 Walker B; other site 395962000872 D-loop; other site 395962000873 H-loop/switch region; other site 395962000874 phytoene desaturase; Region: phytoene_desat; TIGR02731 395962000875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000876 Elongation factor TS; Region: EF_TS; pfam00889 395962000877 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 395962000878 active site lid residues [active] 395962000879 substrate binding pocket [chemical binding]; other site 395962000880 catalytic residues [active] 395962000881 substrate-Mg2+ binding site; other site 395962000882 aspartate-rich region 1; other site 395962000883 aspartate-rich region 2; other site 395962000884 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 395962000885 MAEBL; Provisional; Region: PTZ00121 395962000886 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 395962000887 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 395962000888 Domain of unknown function (DUF814); Region: DUF814; pfam05670 395962000889 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 395962000890 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 395962000891 active site 395962000892 catalytic triad [active] 395962000893 oxyanion hole [active] 395962000894 ferrochelatase; Reviewed; Region: hemH; PRK00035 395962000895 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 395962000896 C-terminal domain interface [polypeptide binding]; other site 395962000897 active site 395962000898 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 395962000899 active site 395962000900 N-terminal domain interface [polypeptide binding]; other site 395962000901 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 395962000902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962000903 S-adenosylmethionine binding site [chemical binding]; other site 395962000904 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 395962000905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962000906 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395962000907 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395962000908 TM-ABC transporter signature motif; other site 395962000909 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 395962000910 nickel binding site [ion binding]; other site 395962000911 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 395962000912 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 395962000913 NAD(P) binding site [chemical binding]; other site 395962000914 catalytic residues [active] 395962000915 tocopherol O-methyltransferase; Region: PLN02244 395962000916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962000917 S-adenosylmethionine binding site [chemical binding]; other site 395962000918 TPR repeat; Region: TPR_11; pfam13414 395962000919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962000920 binding surface 395962000921 TPR motif; other site 395962000922 TPR repeat; Region: TPR_11; pfam13414 395962000923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962000924 binding surface 395962000925 TPR motif; other site 395962000926 TPR repeat; Region: TPR_11; pfam13414 395962000927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962000928 binding surface 395962000929 TPR motif; other site 395962000930 TPR repeat; Region: TPR_11; pfam13414 395962000931 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 395962000932 Protein of unknown function (DUF790); Region: DUF790; pfam05626 395962000933 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 395962000934 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 395962000935 catalytic residues [active] 395962000936 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 395962000937 AMP-binding enzyme; Region: AMP-binding; cl15778 395962000938 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 395962000939 Late competence development protein ComFB; Region: ComFB; pfam10719 395962000940 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 395962000941 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395962000942 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395962000943 DNA binding residues [nucleotide binding] 395962000944 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 395962000945 Putative zinc-finger; Region: zf-HC2; cl15806 395962000946 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 395962000947 putative active site pocket [active] 395962000948 dimerization interface [polypeptide binding]; other site 395962000949 putative catalytic residue [active] 395962000950 PEP-CTERM motif; Region: VPEP; cl15443 395962000951 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 395962000952 tartrate dehydrogenase; Provisional; Region: PRK08194 395962000953 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 395962000954 RNA/DNA binding site [nucleotide binding]; other site 395962000955 RRM dimerization site [polypeptide binding]; other site 395962000956 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 395962000957 aromatic arch; other site 395962000958 DCoH dimer interaction site [polypeptide binding]; other site 395962000959 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 395962000960 DCoH tetramer interaction site [polypeptide binding]; other site 395962000961 substrate binding site [chemical binding]; other site 395962000962 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395962000963 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395962000964 putative switch regulator; other site 395962000965 non-specific DNA interactions [nucleotide binding]; other site 395962000966 DNA binding site [nucleotide binding] 395962000967 sequence specific DNA binding site [nucleotide binding]; other site 395962000968 putative cAMP binding site [chemical binding]; other site 395962000969 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 395962000970 nucleotide binding site [chemical binding]; other site 395962000971 substrate binding site [chemical binding]; other site 395962000972 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 395962000973 nucleotide binding site [chemical binding]; other site 395962000974 substrate binding site [chemical binding]; other site 395962000975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962000976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962000977 S-adenosylmethionine binding site [chemical binding]; other site 395962000978 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 395962000979 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 395962000980 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 395962000981 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 395962000982 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 395962000983 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 395962000984 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962000985 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962000986 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 395962000987 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 395962000988 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 395962000989 Surface antigen; Region: Bac_surface_Ag; cl03097 395962000990 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 395962000991 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 395962000992 ATP binding site [chemical binding]; other site 395962000993 active site 395962000994 substrate binding site [chemical binding]; other site 395962000995 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 395962000996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 395962000997 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 395962000998 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 395962000999 Restriction endonuclease; Region: Mrr_cat; cl00516 395962001000 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395962001001 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395962001002 P-loop; other site 395962001003 Magnesium ion binding site [ion binding]; other site 395962001004 Ion channel; Region: Ion_trans_2; cl11596 395962001005 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 395962001006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001007 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 395962001008 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395962001009 FAD binding domain; Region: FAD_binding_4; pfam01565 395962001010 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 395962001011 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 395962001012 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 395962001013 active site 395962001014 Zn binding site [ion binding]; other site 395962001015 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 395962001016 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 395962001017 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 395962001018 active site 395962001019 Helix-turn-helix domains; Region: HTH; cl00088 395962001020 Winged helix-turn helix; Region: HTH_29; pfam13551 395962001021 Helix-turn-helix domains; Region: HTH; cl00088 395962001022 Integrase core domain; Region: rve; cl01316 395962001023 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 395962001024 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 395962001025 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 395962001026 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 395962001027 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 395962001028 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 395962001029 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 395962001030 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 395962001031 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 395962001032 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 395962001033 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 395962001034 XdhC Rossmann domain; Region: XdhC_C; pfam13478 395962001035 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 395962001036 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 395962001037 substrate binding pocket [chemical binding]; other site 395962001038 chain length determination region; other site 395962001039 substrate-Mg2+ binding site; other site 395962001040 catalytic residues [active] 395962001041 aspartate-rich region 1; other site 395962001042 active site lid residues [active] 395962001043 aspartate-rich region 2; other site 395962001044 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 395962001045 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962001046 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 395962001047 active site 395962001048 ATP binding site [chemical binding]; other site 395962001049 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 395962001050 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 395962001051 MOSC domain; Region: MOSC; pfam03473 395962001052 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 395962001053 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 395962001054 chorismate binding enzyme; Region: Chorismate_bind; cl10555 395962001055 PsaD; Region: PsaD; cl03639 395962001056 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 395962001057 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962001058 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 395962001059 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 395962001060 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 395962001061 catalytic site [active] 395962001062 subunit interface [polypeptide binding]; other site 395962001063 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 395962001064 DNA-binding interface [nucleotide binding]; DNA binding site 395962001065 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001066 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962001067 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001068 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001069 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001070 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001071 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001072 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001073 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 395962001074 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 395962001075 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395962001076 protein binding site [polypeptide binding]; other site 395962001077 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 395962001078 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 395962001079 Ligand binding site; other site 395962001080 Putative Catalytic site; other site 395962001081 DXD motif; other site 395962001082 Domain of unknown function DUF; Region: DUF204; pfam02659 395962001083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001085 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962001086 hypothetical protein; Reviewed; Region: PRK00024 395962001087 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 395962001088 MPN+ (JAMM) motif; other site 395962001089 Zinc-binding site [ion binding]; other site 395962001090 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962001091 putative active site [active] 395962001092 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 395962001093 homotrimer interaction site [polypeptide binding]; other site 395962001094 active site 395962001095 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 395962001096 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 395962001097 tandem repeat interface [polypeptide binding]; other site 395962001098 oligomer interface [polypeptide binding]; other site 395962001099 active site residues [active] 395962001100 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 395962001101 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 395962001102 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 395962001103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 395962001104 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 395962001105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 395962001106 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 395962001107 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 395962001108 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962001109 glutathione reductase; Validated; Region: PRK06116 395962001110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395962001111 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395962001112 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 395962001113 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 395962001114 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395962001115 putative binding surface; other site 395962001116 active site 395962001117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962001118 ATP binding site [chemical binding]; other site 395962001119 Mg2+ binding site [ion binding]; other site 395962001120 G-X-G motif; other site 395962001121 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 395962001122 Response regulator receiver domain; Region: Response_reg; pfam00072 395962001123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962001124 active site 395962001125 phosphorylation site [posttranslational modification] 395962001126 intermolecular recognition site; other site 395962001127 dimerization interface [polypeptide binding]; other site 395962001128 PEP-CTERM motif; Region: VPEP; cl15443 395962001129 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 395962001130 TPR repeat; Region: TPR_11; pfam13414 395962001131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962001132 binding surface 395962001133 TPR motif; other site 395962001134 Peptidase family M48; Region: Peptidase_M48; cl12018 395962001135 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 395962001136 Helix-turn-helix domains; Region: HTH; cl00088 395962001137 Helix-turn-helix domains; Region: HTH; cl00088 395962001138 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 395962001139 putative ABC transporter; Region: ycf24; CHL00085 395962001140 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 395962001141 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 395962001142 Walker A/P-loop; other site 395962001143 ATP binding site [chemical binding]; other site 395962001144 Q-loop/lid; other site 395962001145 ABC transporter signature motif; other site 395962001146 Walker B; other site 395962001147 D-loop; other site 395962001148 H-loop/switch region; other site 395962001149 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 395962001150 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 395962001151 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 395962001152 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 395962001153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395962001154 catalytic residue [active] 395962001155 30S ribosomal protein S1; Reviewed; Region: PRK07400 395962001156 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 395962001157 RNA binding site [nucleotide binding]; other site 395962001158 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 395962001159 RNA binding site [nucleotide binding]; other site 395962001160 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 395962001161 RNA binding site [nucleotide binding]; other site 395962001162 Dienelactone hydrolase family; Region: DLH; pfam01738 395962001163 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962001164 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962001165 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 395962001166 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 395962001167 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 395962001168 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 395962001169 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 395962001170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001171 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 395962001172 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 395962001173 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001174 Response regulator receiver domain; Region: Response_reg; pfam00072 395962001175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962001176 active site 395962001177 phosphorylation site [posttranslational modification] 395962001178 intermolecular recognition site; other site 395962001179 dimerization interface [polypeptide binding]; other site 395962001180 PAS domain S-box; Region: sensory_box; TIGR00229 395962001181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962001182 putative active site [active] 395962001183 heme pocket [chemical binding]; other site 395962001184 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962001185 metal binding site [ion binding]; metal-binding site 395962001186 active site 395962001187 I-site; other site 395962001188 PAS domain S-box; Region: sensory_box; TIGR00229 395962001189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962001190 putative active site [active] 395962001191 heme pocket [chemical binding]; other site 395962001192 PAS domain S-box; Region: sensory_box; TIGR00229 395962001193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962001194 putative active site [active] 395962001195 heme pocket [chemical binding]; other site 395962001196 PAS fold; Region: PAS_4; pfam08448 395962001197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962001198 PAS fold; Region: PAS_3; pfam08447 395962001199 putative active site [active] 395962001200 heme pocket [chemical binding]; other site 395962001201 PAS domain S-box; Region: sensory_box; TIGR00229 395962001202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962001203 putative active site [active] 395962001204 heme pocket [chemical binding]; other site 395962001205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962001206 PAS fold; Region: PAS_3; pfam08447 395962001207 putative active site [active] 395962001208 heme pocket [chemical binding]; other site 395962001209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 395962001210 Histidine kinase; Region: HisKA_2; cl06527 395962001211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962001212 ATP binding site [chemical binding]; other site 395962001213 Mg2+ binding site [ion binding]; other site 395962001214 G-X-G motif; other site 395962001215 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 395962001216 AMP binding site [chemical binding]; other site 395962001217 fructose-1,6-bisphosphatase family protein; Region: PLN02628 395962001218 metal binding site [ion binding]; metal-binding site 395962001219 active site 395962001220 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 395962001221 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001222 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 395962001223 catalytic triad [active] 395962001224 S-layer homology domain; Region: SLH; pfam00395 395962001225 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 395962001226 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 395962001227 cysteine synthase; Region: PLN02565 395962001228 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 395962001229 dimer interface [polypeptide binding]; other site 395962001230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962001231 catalytic residue [active] 395962001232 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395962001233 HSP70 interaction site [polypeptide binding]; other site 395962001234 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 395962001235 putative homotetramer interface [polypeptide binding]; other site 395962001236 putative homodimer interface [polypeptide binding]; other site 395962001237 putative metal binding site [ion binding]; other site 395962001238 putative homodimer-homodimer interface [polypeptide binding]; other site 395962001239 putative allosteric switch controlling residues; other site 395962001240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962001241 active site 395962001242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962001243 binding surface 395962001244 TPR motif; other site 395962001245 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962001246 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 395962001247 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 395962001248 active site 395962001249 dimer interface [polypeptide binding]; other site 395962001250 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 395962001251 dimer interface [polypeptide binding]; other site 395962001252 active site 395962001253 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 395962001254 putative active site [active] 395962001255 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 395962001256 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 395962001257 homooctamer interface [polypeptide binding]; other site 395962001258 active site 395962001259 Rhomboid family; Region: Rhomboid; cl11446 395962001260 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395962001261 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962001262 active site 395962001263 ATP binding site [chemical binding]; other site 395962001264 substrate binding site [chemical binding]; other site 395962001265 activation loop (A-loop); other site 395962001266 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 395962001267 Malic enzyme, N-terminal domain; Region: malic; pfam00390 395962001268 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 395962001269 putative NAD(P) binding site [chemical binding]; other site 395962001270 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 395962001271 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 395962001272 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 395962001273 active site 395962001274 catalytic residues [active] 395962001275 metal binding site [ion binding]; metal-binding site 395962001276 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 395962001277 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395962001278 catalytic loop [active] 395962001279 iron binding site [ion binding]; other site 395962001280 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962001281 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962001282 glycogen branching enzyme; Provisional; Region: PRK05402 395962001283 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 395962001284 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 395962001285 active site 395962001286 catalytic site [active] 395962001287 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 395962001288 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 395962001289 active site 395962001290 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 395962001291 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001292 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 395962001293 dinuclear metal binding motif [ion binding]; other site 395962001294 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 395962001295 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 395962001296 active site 395962001297 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 395962001298 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 395962001299 active site 395962001300 HIGH motif; other site 395962001301 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 395962001302 KMSKS motif; other site 395962001303 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 395962001304 tRNA binding surface [nucleotide binding]; other site 395962001305 anticodon binding site; other site 395962001306 Transposase IS200 like; Region: Y1_Tnp; cl00848 395962001307 CHAT domain; Region: CHAT; pfam12770 395962001308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962001309 binding surface 395962001310 TPR motif; other site 395962001311 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962001312 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962001313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962001314 binding surface 395962001315 TPR motif; other site 395962001316 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962001317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962001318 binding surface 395962001319 TPR motif; other site 395962001320 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962001321 TPR repeat; Region: TPR_11; pfam13414 395962001322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962001323 binding surface 395962001324 TPR motif; other site 395962001325 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 395962001326 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 395962001327 active site 395962001328 homodimer interface [polypeptide binding]; other site 395962001329 uridine kinase; Validated; Region: PRK06696 395962001330 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001331 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 395962001332 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 395962001333 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 395962001334 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962001335 putative active site [active] 395962001336 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 395962001337 Helix-turn-helix domains; Region: HTH; cl00088 395962001338 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 395962001339 putative dimerization interface [polypeptide binding]; other site 395962001340 Phospholipid methyltransferase; Region: PEMT; cl00763 395962001341 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 395962001342 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 395962001343 TPP-binding site; other site 395962001344 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 395962001345 PYR/PP interface [polypeptide binding]; other site 395962001346 dimer interface [polypeptide binding]; other site 395962001347 TPP binding site [chemical binding]; other site 395962001348 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395962001349 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 395962001350 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 395962001351 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 395962001352 catalytic triad [active] 395962001353 dimer interface [polypeptide binding]; other site 395962001354 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395962001355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962001356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962001357 active site 395962001358 phosphorylation site [posttranslational modification] 395962001359 intermolecular recognition site; other site 395962001360 dimerization interface [polypeptide binding]; other site 395962001361 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962001362 DNA binding site [nucleotide binding] 395962001363 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395962001364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962001365 dimerization interface [polypeptide binding]; other site 395962001366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962001367 dimer interface [polypeptide binding]; other site 395962001368 phosphorylation site [posttranslational modification] 395962001369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962001370 ATP binding site [chemical binding]; other site 395962001371 Mg2+ binding site [ion binding]; other site 395962001372 G-X-G motif; other site 395962001373 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 395962001374 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 395962001375 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 395962001376 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 395962001377 NADP binding site [chemical binding]; other site 395962001378 active site 395962001379 putative substrate binding site [chemical binding]; other site 395962001380 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 395962001381 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 395962001382 substrate binding site; other site 395962001383 metal-binding site 395962001384 Oligomer interface; other site 395962001385 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 395962001386 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 395962001387 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 395962001388 NAD binding site [chemical binding]; other site 395962001389 substrate binding site [chemical binding]; other site 395962001390 homodimer interface [polypeptide binding]; other site 395962001391 active site 395962001392 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 395962001393 GAF domain; Region: GAF; cl15785 395962001394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395962001395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962001396 dimer interface [polypeptide binding]; other site 395962001397 phosphorylation site [posttranslational modification] 395962001398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962001399 ATP binding site [chemical binding]; other site 395962001400 Mg2+ binding site [ion binding]; other site 395962001401 G-X-G motif; other site 395962001402 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 395962001403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 395962001404 Haemolysin XhlA; Region: XhlA; pfam10779 395962001405 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 395962001406 nucleoside/Zn binding site; other site 395962001407 dimer interface [polypeptide binding]; other site 395962001408 catalytic motif [active] 395962001409 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 395962001410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001411 NAD(P) binding site [chemical binding]; other site 395962001412 active site 395962001413 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 395962001414 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 395962001415 dimer interface [polypeptide binding]; other site 395962001416 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 395962001417 molecular chaperone DnaK; Provisional; Region: PRK13411 395962001418 Cell division protein FtsA; Region: FtsA; cl11496 395962001419 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 395962001420 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 395962001421 homotrimer interaction site [polypeptide binding]; other site 395962001422 putative active site [active] 395962001423 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 395962001424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395962001425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962001426 homodimer interface [polypeptide binding]; other site 395962001427 catalytic residue [active] 395962001428 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 395962001429 HflK protein; Region: hflK; TIGR01933 395962001430 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 395962001431 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 395962001432 Protein export membrane protein; Region: SecD_SecF; cl14618 395962001433 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 395962001434 substrate binding pocket [chemical binding]; other site 395962001435 substrate-Mg2+ binding site; other site 395962001436 aspartate-rich region 1; other site 395962001437 aspartate-rich region 2; other site 395962001438 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 395962001439 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 395962001440 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 395962001441 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 395962001442 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cl11870 395962001443 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869 395962001444 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 395962001445 CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174 395962001446 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001447 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 395962001448 Predicted transcriptional regulator [Transcription]; Region: COG2378 395962001449 WYL domain; Region: WYL; cl14852 395962001450 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 395962001451 mce related protein; Region: MCE; pfam02470 395962001452 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 395962001453 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 395962001454 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 395962001455 Walker A/P-loop; other site 395962001456 ATP binding site [chemical binding]; other site 395962001457 Q-loop/lid; other site 395962001458 ABC transporter signature motif; other site 395962001459 Walker B; other site 395962001460 D-loop; other site 395962001461 H-loop/switch region; other site 395962001462 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 395962001463 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 395962001464 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 395962001465 Uncharacterized conserved protein [Function unknown]; Region: COG3349 395962001466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001467 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 395962001468 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 395962001469 iron-sulfur cluster [ion binding]; other site 395962001470 [2Fe-2S] cluster binding site [ion binding]; other site 395962001471 Uncharacterized conserved protein [Function unknown]; Region: COG3349 395962001472 CHAT domain; Region: CHAT; pfam12770 395962001473 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 395962001474 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 395962001475 Walker A/P-loop; other site 395962001476 ATP binding site [chemical binding]; other site 395962001477 Q-loop/lid; other site 395962001478 ABC transporter signature motif; other site 395962001479 Walker B; other site 395962001480 D-loop; other site 395962001481 H-loop/switch region; other site 395962001482 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 395962001483 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 395962001484 malate dehydrogenase; Reviewed; Region: PRK06223 395962001485 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 395962001486 NAD(P) binding site [chemical binding]; other site 395962001487 dimer interface [polypeptide binding]; other site 395962001488 tetramer (dimer of dimers) interface [polypeptide binding]; other site 395962001489 substrate binding site [chemical binding]; other site 395962001490 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 395962001491 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 395962001492 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 395962001493 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 395962001494 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962001495 metal binding site [ion binding]; metal-binding site 395962001496 active site 395962001497 I-site; other site 395962001498 arginine-tRNA ligase; Region: PLN02286 395962001499 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 395962001500 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 395962001501 active site 395962001502 HIGH motif; other site 395962001503 KMSK motif region; other site 395962001504 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 395962001505 tRNA binding surface [nucleotide binding]; other site 395962001506 anticodon binding site; other site 395962001507 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 395962001508 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962001509 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 395962001510 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 395962001511 carboxyltransferase (CT) interaction site; other site 395962001512 biotinylation site [posttranslational modification]; other site 395962001513 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962001514 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395962001515 ligand binding site [chemical binding]; other site 395962001516 flexible hinge region; other site 395962001517 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 395962001518 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cd02259 395962001519 putative active site [active] 395962001520 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 395962001521 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001522 Walker A/P-loop; other site 395962001523 ATP binding site [chemical binding]; other site 395962001524 Q-loop/lid; other site 395962001525 ABC transporter signature motif; other site 395962001526 Walker B; other site 395962001527 D-loop; other site 395962001528 H-loop/switch region; other site 395962001529 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 395962001530 PPIC-type PPIASE domain; Region: Rotamase; cl08278 395962001531 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 395962001532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962001533 active site 395962001534 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 395962001535 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 395962001536 ResB-like family; Region: ResB; pfam05140 395962001537 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395962001538 catalytic loop [active] 395962001539 iron binding site [ion binding]; other site 395962001540 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 395962001541 active site 395962001542 dimerization interface [polypeptide binding]; other site 395962001543 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395962001544 HSP70 interaction site [polypeptide binding]; other site 395962001545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962001546 binding surface 395962001547 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395962001548 TPR motif; other site 395962001549 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 395962001550 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 395962001551 molybdopterin cofactor binding site; other site 395962001552 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 395962001553 molybdopterin cofactor binding site; other site 395962001554 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 395962001555 active site 395962001556 Ycf4; Region: Ycf4; cl03567 395962001557 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962001558 Protein of unknown function, DUF482; Region: DUF482; pfam04339 395962001559 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 395962001560 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001561 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962001562 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001563 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001564 CTP synthetase; Validated; Region: pyrG; PRK05380 395962001565 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 395962001566 Catalytic site [active] 395962001567 active site 395962001568 UTP binding site [chemical binding]; other site 395962001569 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 395962001570 active site 395962001571 putative oxyanion hole; other site 395962001572 catalytic triad [active] 395962001573 elongation factor P; Validated; Region: PRK00529 395962001574 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 395962001575 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 395962001576 RNA binding site [nucleotide binding]; other site 395962001577 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 395962001578 RNA binding site [nucleotide binding]; other site 395962001579 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 395962001580 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 395962001581 carboxyltransferase (CT) interaction site; other site 395962001582 biotinylation site [posttranslational modification]; other site 395962001583 Peptidase family M48; Region: Peptidase_M48; cl12018 395962001584 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 395962001585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001586 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 395962001587 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 395962001588 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962001589 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 395962001590 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 395962001591 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001592 HEAT repeats; Region: HEAT_2; pfam13646 395962001593 HEAT repeats; Region: HEAT_2; pfam13646 395962001594 HEAT repeats; Region: HEAT_2; pfam13646 395962001595 HEAT repeats; Region: HEAT_2; pfam13646 395962001596 HEAT repeats; Region: HEAT_2; pfam13646 395962001597 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 395962001598 GIY-YIG motif/motif A; other site 395962001599 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 395962001600 ATP-sulfurylase; Region: ATPS; cd00517 395962001601 active site 395962001602 HXXH motif; other site 395962001603 flexible loop; other site 395962001604 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 395962001605 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 395962001606 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395962001607 catalytic residues [active] 395962001608 DNA gyrase subunit A; Validated; Region: PRK05560 395962001609 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 395962001610 CAP-like domain; other site 395962001611 active site 395962001612 primary dimer interface [polypeptide binding]; other site 395962001613 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395962001614 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395962001615 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395962001616 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395962001617 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395962001618 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395962001619 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 395962001620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962001621 ATP binding site [chemical binding]; other site 395962001622 putative Mg++ binding site [ion binding]; other site 395962001623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395962001624 nucleotide binding region [chemical binding]; other site 395962001625 ATP-binding site [chemical binding]; other site 395962001626 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 395962001627 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 395962001628 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001629 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 395962001630 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962001631 structural tetrad; other site 395962001632 FOG: WD40 repeat [General function prediction only]; Region: COG2319 395962001633 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962001634 structural tetrad; other site 395962001635 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 395962001636 TIR domain; Region: TIR_2; cl15770 395962001637 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 395962001638 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 395962001639 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962001640 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 395962001641 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 395962001642 D-pathway; other site 395962001643 Putative ubiquinol binding site [chemical binding]; other site 395962001644 Low-spin heme (heme b) binding site [chemical binding]; other site 395962001645 Putative water exit pathway; other site 395962001646 Binuclear center (heme o3/CuB) [ion binding]; other site 395962001647 K-pathway; other site 395962001648 Putative proton exit pathway; other site 395962001649 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 395962001650 Subunit I/III interface [polypeptide binding]; other site 395962001651 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962001652 signal recognition particle protein; Provisional; Region: PRK10867 395962001653 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 395962001654 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 395962001655 P loop; other site 395962001656 GTP binding site [chemical binding]; other site 395962001657 Signal peptide binding domain; Region: SRP_SPB; pfam02978 395962001658 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 395962001659 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962001660 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962001661 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001662 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962001663 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 395962001664 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 395962001665 active site 395962001666 catalytic residues [active] 395962001667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 395962001668 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 395962001669 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962001670 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 395962001671 active site 395962001672 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 395962001673 TPR repeat; Region: TPR_11; pfam13414 395962001674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962001675 binding surface 395962001676 TPR motif; other site 395962001677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962001678 binding surface 395962001679 TPR repeat; Region: TPR_11; pfam13414 395962001680 TPR motif; other site 395962001681 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 395962001682 dimer interface [polypeptide binding]; other site 395962001683 catalytic triad [active] 395962001684 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962001685 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 395962001686 AMIN domain; Region: AMIN; pfam11741 395962001687 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 395962001688 active site 395962001689 metal binding site [ion binding]; metal-binding site 395962001690 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 395962001691 ArsC family; Region: ArsC; pfam03960 395962001692 catalytic residues [active] 395962001693 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 395962001694 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 395962001695 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962001696 putative active site [active] 395962001697 arogenate dehydrogenase; Reviewed; Region: PRK07417 395962001698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001699 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 395962001700 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 395962001701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001702 NAD(P) binding site [chemical binding]; other site 395962001703 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 395962001704 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 395962001705 DXD motif; other site 395962001706 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 395962001707 TM2 domain; Region: TM2; cl00984 395962001708 Short C-terminal domain; Region: SHOCT; cl01373 395962001709 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 395962001710 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 395962001711 putative hydrophobic ligand binding site [chemical binding]; other site 395962001712 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 395962001713 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962001714 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 395962001715 C-terminal peptidase (prc); Region: prc; TIGR00225 395962001716 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 395962001717 protein binding site [polypeptide binding]; other site 395962001718 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 395962001719 Catalytic dyad [active] 395962001720 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 395962001721 phosphoenolpyruvate synthase; Validated; Region: PRK06241 395962001722 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 395962001723 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 395962001724 Bacterial Ig-like domain; Region: Big_5; cl01012 395962001725 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 395962001726 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 395962001727 Recombinase; Region: Recombinase; pfam07508 395962001728 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 395962001729 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 395962001730 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 395962001731 active site 395962001732 (T/H)XGH motif; other site 395962001733 cell division protein; Validated; Region: ftsH; CHL00176 395962001734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962001735 Walker A motif; other site 395962001736 ATP binding site [chemical binding]; other site 395962001737 Walker B motif; other site 395962001738 arginine finger; other site 395962001739 Peptidase family M41; Region: Peptidase_M41; pfam01434 395962001740 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 395962001741 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 395962001742 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 395962001743 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 395962001744 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 395962001745 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 395962001746 putative active site [active] 395962001747 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 395962001748 Predicted ATPase [General function prediction only]; Region: COG4637 395962001749 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 395962001750 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 395962001751 Q-loop/lid; other site 395962001752 ABC transporter signature motif; other site 395962001753 Walker B; other site 395962001754 D-loop; other site 395962001755 H-loop/switch region; other site 395962001756 Protein of unknown function (DUF423); Region: DUF423; cl01008 395962001757 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 395962001758 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395962001759 NAD binding site [chemical binding]; other site 395962001760 substrate binding site [chemical binding]; other site 395962001761 active site 395962001762 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 395962001763 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 395962001764 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395962001765 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962001766 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 395962001767 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395962001768 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962001769 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 395962001770 IMP binding site; other site 395962001771 dimer interface [polypeptide binding]; other site 395962001772 interdomain contacts; other site 395962001773 partial ornithine binding site; other site 395962001774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395962001775 substrate binding pocket [chemical binding]; other site 395962001776 membrane-bound complex binding site; other site 395962001777 hinge residues; other site 395962001778 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962001779 Peptidase family M23; Region: Peptidase_M23; pfam01551 395962001780 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 395962001781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001782 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 395962001783 folate binding site [chemical binding]; other site 395962001784 NADP+ binding site [chemical binding]; other site 395962001785 Cupin domain; Region: Cupin_2; cl09118 395962001786 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 395962001787 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 395962001788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001789 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 395962001790 Fatty acid desaturase; Region: FA_desaturase; pfam00487 395962001791 Di-iron ligands [ion binding]; other site 395962001792 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 395962001793 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395962001794 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 395962001795 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 395962001796 dimerization interface [polypeptide binding]; other site 395962001797 active site 395962001798 metal binding site [ion binding]; metal-binding site 395962001799 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 395962001800 dimerization interface [polypeptide binding]; other site 395962001801 active site 395962001802 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 395962001803 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 395962001804 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 395962001805 active site 395962001806 catalytic site [active] 395962001807 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 395962001808 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 395962001809 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 395962001810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962001811 Coenzyme A binding pocket [chemical binding]; other site 395962001812 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 395962001813 putative metal binding site [ion binding]; other site 395962001814 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 395962001815 tellurium resistance terB-like protein; Region: terB_like; cd07177 395962001816 metal binding site [ion binding]; metal-binding site 395962001817 16S rRNA methyltransferase B; Provisional; Region: PRK14901 395962001818 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 395962001819 putative RNA binding site [nucleotide binding]; other site 395962001820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962001821 S-adenosylmethionine binding site [chemical binding]; other site 395962001822 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 395962001823 metal ion-dependent adhesion site (MIDAS); other site 395962001824 Cysteine dioxygenase type I; Region: CDO_I; cl15835 395962001825 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 395962001826 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 395962001827 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 395962001828 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 395962001829 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001830 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001831 AAA domain; Region: AAA_21; pfam13304 395962001832 Walker A/P-loop; other site 395962001833 Walker A/P-loop; other site 395962001834 ATP binding site [chemical binding]; other site 395962001835 ATP binding site [chemical binding]; other site 395962001836 Q-loop/lid; other site 395962001837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001838 Walker B motif; other site 395962001839 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 395962001840 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 395962001841 B12 binding site [chemical binding]; other site 395962001842 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 395962001843 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 395962001844 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395962001845 anti sigma factor interaction site; other site 395962001846 regulatory phosphorylation site [posttranslational modification]; other site 395962001847 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 395962001848 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962001849 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 395962001850 Flavin Reductases; Region: FlaRed; cl00801 395962001851 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 395962001852 putative active site [active] 395962001853 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 395962001854 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395962001855 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 395962001856 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395962001857 DNA binding residues [nucleotide binding] 395962001858 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 395962001859 light-harvesting-like protein 3; Provisional; Region: PLN00014 395962001860 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962001861 structural tetrad; other site 395962001862 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 395962001863 Protein of unknown function, DUF393; Region: DUF393; cl01136 395962001864 Transposase; Region: HTH_Tnp_IS630; pfam01710 395962001865 Integrase core domain; Region: rve; cl01316 395962001866 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962001867 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 395962001868 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962001869 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 395962001870 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395962001871 active site 395962001872 HIGH motif; other site 395962001873 nucleotide binding site [chemical binding]; other site 395962001874 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 395962001875 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 395962001876 active site 395962001877 KMSKS motif; other site 395962001878 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 395962001879 tRNA binding surface [nucleotide binding]; other site 395962001880 anticodon binding site; other site 395962001881 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 395962001882 phosphodiesterase; Provisional; Region: PRK12704 395962001883 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 395962001884 aromatic arch; other site 395962001885 DCoH dimer interaction site [polypeptide binding]; other site 395962001886 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 395962001887 DCoH tetramer interaction site [polypeptide binding]; other site 395962001888 substrate binding site [chemical binding]; other site 395962001889 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 395962001890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395962001891 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 395962001892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962001893 motif II; other site 395962001894 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 395962001895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962001896 FeS/SAM binding site; other site 395962001897 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 395962001898 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 395962001899 Ligand Binding Site [chemical binding]; other site 395962001900 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 395962001901 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 395962001902 substrate binding site [chemical binding]; other site 395962001903 glutamase interaction surface [polypeptide binding]; other site 395962001904 Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cl00012 395962001905 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962001906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962001907 Coenzyme A binding pocket [chemical binding]; other site 395962001908 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 395962001909 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 395962001910 homodimer interface [polypeptide binding]; other site 395962001911 active site 395962001912 TDP-binding site; other site 395962001913 acceptor substrate-binding pocket; other site 395962001914 Helix-turn-helix domains; Region: HTH; cl00088 395962001915 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 395962001916 Methyltransferase domain; Region: Methyltransf_31; pfam13847 395962001917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962001918 S-adenosylmethionine binding site [chemical binding]; other site 395962001919 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962001920 putative active site [active] 395962001921 GMP synthase; Reviewed; Region: guaA; PRK00074 395962001922 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 395962001923 AMP/PPi binding site [chemical binding]; other site 395962001924 candidate oxyanion hole; other site 395962001925 catalytic triad [active] 395962001926 potential glutamine specificity residues [chemical binding]; other site 395962001927 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 395962001928 ATP Binding subdomain [chemical binding]; other site 395962001929 Ligand Binding sites [chemical binding]; other site 395962001930 Dimerization subdomain; other site 395962001931 L-aspartate oxidase; Provisional; Region: PRK07395 395962001932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001933 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 395962001934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962001935 HEAT repeats; Region: HEAT_2; pfam13646 395962001936 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 395962001937 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 395962001938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962001939 ATP binding site [chemical binding]; other site 395962001940 putative Mg++ binding site [ion binding]; other site 395962001941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001942 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 395962001943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962001944 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 395962001945 Leucine-zipper of ternary complex factor MIP1; Region: Lzipper-MIP1; pfam14389 395962001946 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395962001947 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395962001948 Chromate transporter; Region: Chromate_transp; pfam02417 395962001949 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 395962001950 Chromate transporter; Region: Chromate_transp; pfam02417 395962001951 DNA photolyase; Region: DNA_photolyase; pfam00875 395962001952 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 395962001953 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 395962001954 GUN4-like; Region: GUN4; pfam05419 395962001955 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 395962001956 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001957 Walker A/P-loop; other site 395962001958 ATP binding site [chemical binding]; other site 395962001959 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962001960 Walker B; other site 395962001961 D-loop; other site 395962001962 H-loop/switch region; other site 395962001963 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962001964 putative active site [active] 395962001965 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 395962001966 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 395962001967 GDP-binding site [chemical binding]; other site 395962001968 ACT binding site; other site 395962001969 IMP binding site; other site 395962001970 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 395962001971 5S rRNA interface [nucleotide binding]; other site 395962001972 CTC domain interface [polypeptide binding]; other site 395962001973 L16 interface [polypeptide binding]; other site 395962001974 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 395962001975 metal-binding site 395962001976 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395962001977 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962001978 active site 395962001979 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 395962001980 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 395962001981 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 395962001982 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 395962001983 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 395962001984 trimer interface [polypeptide binding]; other site 395962001985 active site 395962001986 dimer interface [polypeptide binding]; other site 395962001987 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 395962001988 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 395962001989 Walker A/P-loop; other site 395962001990 ATP binding site [chemical binding]; other site 395962001991 Q-loop/lid; other site 395962001992 ABC transporter signature motif; other site 395962001993 Walker B; other site 395962001994 D-loop; other site 395962001995 H-loop/switch region; other site 395962001996 Ferredoxin [Energy production and conversion]; Region: COG1146 395962001997 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 395962001998 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395962001999 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962002000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962002001 binding surface 395962002002 TPR motif; other site 395962002003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 395962002004 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395962002005 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395962002006 dimer interface [polypeptide binding]; other site 395962002007 putative CheW interface [polypeptide binding]; other site 395962002008 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962002009 Response regulator receiver domain; Region: Response_reg; pfam00072 395962002010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962002011 active site 395962002012 phosphorylation site [posttranslational modification] 395962002013 intermolecular recognition site; other site 395962002014 dimerization interface [polypeptide binding]; other site 395962002015 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 395962002016 Response regulator receiver domain; Region: Response_reg; pfam00072 395962002017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962002018 active site 395962002019 phosphorylation site [posttranslational modification] 395962002020 intermolecular recognition site; other site 395962002021 dimerization interface [polypeptide binding]; other site 395962002022 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 395962002023 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 395962002024 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 395962002025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962002026 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 395962002027 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 395962002028 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 395962002029 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 395962002030 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 395962002031 active site 395962002032 dimer interface [polypeptide binding]; other site 395962002033 motif 1; other site 395962002034 motif 2; other site 395962002035 motif 3; other site 395962002036 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 395962002037 anticodon binding site; other site 395962002038 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962002039 phosphopeptide binding site; other site 395962002040 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 395962002041 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 395962002042 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962002043 Walker A/P-loop; other site 395962002044 ATP binding site [chemical binding]; other site 395962002045 Q-loop/lid; other site 395962002046 ABC transporter signature motif; other site 395962002047 Walker B; other site 395962002048 D-loop; other site 395962002049 H-loop/switch region; other site 395962002050 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395962002051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395962002052 ligand binding site [chemical binding]; other site 395962002053 flexible hinge region; other site 395962002054 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 395962002055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002056 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 395962002057 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 395962002058 calmodulin; Provisional; Region: PTZ00184 395962002059 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 395962002060 Ca2+ binding site [ion binding]; other site 395962002061 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 395962002062 Ca2+ binding site [ion binding]; other site 395962002063 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395962002064 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 395962002065 PDGLE domain; Region: PDGLE; cl07986 395962002066 Cobalt transport protein; Region: CbiQ; cl00463 395962002067 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 395962002068 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 395962002069 ligand binding site; other site 395962002070 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 395962002071 active site 395962002072 metal binding site [ion binding]; metal-binding site 395962002073 Predicted ATPases [General function prediction only]; Region: COG1106 395962002074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962002075 Walker A/P-loop; other site 395962002076 ATP binding site [chemical binding]; other site 395962002077 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 395962002078 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395962002079 RNA binding surface [nucleotide binding]; other site 395962002080 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 395962002081 active site 395962002082 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 395962002083 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 395962002084 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 395962002085 NAD(P) binding site [chemical binding]; other site 395962002086 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 395962002087 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 395962002088 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 395962002089 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 395962002090 cytochrome b subunit interaction site [polypeptide binding]; other site 395962002091 [2Fe-2S] cluster binding site [ion binding]; other site 395962002092 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 395962002093 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 395962002094 dimer interface [polypeptide binding]; other site 395962002095 glycine-pyridoxal phosphate binding site [chemical binding]; other site 395962002096 active site 395962002097 folate binding site [chemical binding]; other site 395962002098 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 395962002099 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 395962002100 active site 395962002101 dimer interface [polypeptide binding]; other site 395962002102 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 395962002103 active site 395962002104 dimer interface [polypeptide binding]; other site 395962002105 type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 395962002106 Response regulator receiver domain; Region: Response_reg; pfam00072 395962002107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962002108 active site 395962002109 phosphorylation site [posttranslational modification] 395962002110 intermolecular recognition site; other site 395962002111 dimerization interface [polypeptide binding]; other site 395962002112 CHASE3 domain; Region: CHASE3; cl05000 395962002113 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395962002114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395962002115 dimer interface [polypeptide binding]; other site 395962002116 putative CheW interface [polypeptide binding]; other site 395962002117 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395962002118 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395962002119 dimer interface [polypeptide binding]; other site 395962002120 putative CheW interface [polypeptide binding]; other site 395962002121 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 395962002122 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395962002123 putative binding surface; other site 395962002124 active site 395962002125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962002126 ATP binding site [chemical binding]; other site 395962002127 Mg2+ binding site [ion binding]; other site 395962002128 G-X-G motif; other site 395962002129 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962002130 Response regulator receiver domain; Region: Response_reg; pfam00072 395962002131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962002132 active site 395962002133 phosphorylation site [posttranslational modification] 395962002134 intermolecular recognition site; other site 395962002135 dimerization interface [polypeptide binding]; other site 395962002136 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 395962002137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962002138 active site 395962002139 phosphorylation site [posttranslational modification] 395962002140 intermolecular recognition site; other site 395962002141 dimerization interface [polypeptide binding]; other site 395962002142 CheB methylesterase; Region: CheB_methylest; pfam01339 395962002143 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 395962002144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962002146 TPR motif; other site 395962002147 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395962002148 binding surface 395962002149 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 395962002150 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962002151 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962002152 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962002153 putative active site [active] 395962002154 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 395962002155 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 395962002156 elongation factor G; Reviewed; Region: PRK00007 395962002157 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 395962002158 G1 box; other site 395962002159 putative GEF interaction site [polypeptide binding]; other site 395962002160 GTP/Mg2+ binding site [chemical binding]; other site 395962002161 Switch I region; other site 395962002162 G2 box; other site 395962002163 G3 box; other site 395962002164 Switch II region; other site 395962002165 G4 box; other site 395962002166 G5 box; other site 395962002167 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 395962002168 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 395962002169 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 395962002170 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 395962002171 NodB motif; other site 395962002172 active site 395962002173 catalytic site [active] 395962002174 metal binding site [ion binding]; metal-binding site 395962002175 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 395962002176 MoaE homodimer interface [polypeptide binding]; other site 395962002177 MoaD interaction [polypeptide binding]; other site 395962002178 active site residues [active] 395962002179 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 395962002180 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 395962002181 intersubunit interface [polypeptide binding]; other site 395962002182 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 395962002183 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 395962002184 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 395962002185 ABC-ATPase subunit interface; other site 395962002186 dimer interface [polypeptide binding]; other site 395962002187 putative PBP binding regions; other site 395962002188 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 395962002189 dimer interface [polypeptide binding]; other site 395962002190 active site 395962002191 aspartate-rich active site metal binding site; other site 395962002192 allosteric magnesium binding site [ion binding]; other site 395962002193 Schiff base residues; other site 395962002194 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 395962002195 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395962002196 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395962002197 catalytic residue [active] 395962002198 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 395962002199 active site 395962002200 metal binding site [ion binding]; metal-binding site 395962002201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962002202 S-adenosylmethionine binding site [chemical binding]; other site 395962002203 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 395962002204 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395962002205 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 395962002206 active site 395962002207 metal binding site [ion binding]; metal-binding site 395962002208 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962002209 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962002210 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962002211 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 395962002212 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 395962002213 Hexamer interface [polypeptide binding]; other site 395962002214 Hexagonal pore residue; other site 395962002215 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 395962002216 Hexamer interface [polypeptide binding]; other site 395962002217 Hexagonal pore residue; other site 395962002218 Quinolinate synthetase A protein; Region: NadA; cl00420 395962002219 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 395962002220 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 395962002221 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 395962002222 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 395962002223 P-loop; other site 395962002224 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 395962002225 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 395962002226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962002227 dimerization interface [polypeptide binding]; other site 395962002228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962002229 PAS domain; Region: PAS_9; pfam13426 395962002230 putative active site [active] 395962002231 heme pocket [chemical binding]; other site 395962002232 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 395962002233 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 395962002234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 395962002235 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 395962002236 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 395962002237 putative peptidoglycan binding site; other site 395962002238 Peptidase family M23; Region: Peptidase_M23; pfam01551 395962002239 homoserine dehydrogenase; Provisional; Region: PRK06349 395962002240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002241 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 395962002242 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 395962002243 hydrolase; Region: PLN02578 395962002244 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 395962002245 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 395962002246 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 395962002247 Predicted integral membrane protein [Function unknown]; Region: COG0392 395962002248 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 395962002249 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962002250 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 395962002251 Flavin Reductases; Region: FlaRed; cl00801 395962002252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002253 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 395962002254 Phycobilisome protein; Region: Phycobilisome; cl08227 395962002255 glutamine synthetase, type I; Region: GlnA; TIGR00653 395962002256 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 395962002257 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 395962002258 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 395962002259 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962002260 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 395962002261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962002262 active site 395962002263 phosphorylation site [posttranslational modification] 395962002264 intermolecular recognition site; other site 395962002265 dimerization interface [polypeptide binding]; other site 395962002266 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395962002267 Zn2+ binding site [ion binding]; other site 395962002268 Mg2+ binding site [ion binding]; other site 395962002269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 395962002270 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 395962002271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962002273 active site 395962002274 competence damage-inducible protein A; Provisional; Region: PRK00549 395962002275 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 395962002276 putative MPT binding site; other site 395962002277 Competence-damaged protein; Region: CinA; cl00666 395962002278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962002279 binding surface 395962002280 TPR motif; other site 395962002281 TPR repeat; Region: TPR_11; pfam13414 395962002282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962002283 binding surface 395962002284 TPR motif; other site 395962002285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962002286 binding surface 395962002287 TPR repeat; Region: TPR_11; pfam13414 395962002288 TPR motif; other site 395962002289 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962002290 hybrid cluster protein; Provisional; Region: PRK05290 395962002291 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395962002292 ACS interaction site; other site 395962002293 CODH interaction site; other site 395962002294 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 395962002295 hybrid metal cluster; other site 395962002296 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 395962002297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002298 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 395962002299 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 395962002300 active site 395962002301 substrate binding site [chemical binding]; other site 395962002302 metal binding site [ion binding]; metal-binding site 395962002303 PAS domain S-box; Region: sensory_box; TIGR00229 395962002304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962002305 putative active site [active] 395962002306 heme pocket [chemical binding]; other site 395962002307 GAF domain; Region: GAF_2; pfam13185 395962002308 GAF domain; Region: GAF; cl15785 395962002309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962002310 dimer interface [polypeptide binding]; other site 395962002311 phosphorylation site [posttranslational modification] 395962002312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962002313 ATP binding site [chemical binding]; other site 395962002314 Mg2+ binding site [ion binding]; other site 395962002315 G-X-G motif; other site 395962002316 Response regulator receiver domain; Region: Response_reg; pfam00072 395962002317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962002318 active site 395962002319 phosphorylation site [posttranslational modification] 395962002320 intermolecular recognition site; other site 395962002321 dimerization interface [polypeptide binding]; other site 395962002322 Response regulator receiver domain; Region: Response_reg; pfam00072 395962002323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962002324 active site 395962002325 phosphorylation site [posttranslational modification] 395962002326 intermolecular recognition site; other site 395962002327 dimerization interface [polypeptide binding]; other site 395962002328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962002329 metal binding site [ion binding]; metal-binding site 395962002330 active site 395962002331 I-site; other site 395962002332 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962002333 FAD binding domain; Region: FAD_binding_4; pfam01565 395962002334 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 395962002335 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 395962002336 putative active site [active] 395962002337 putative metal binding site [ion binding]; other site 395962002338 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 395962002339 PEP-CTERM motif; Region: VPEP; cl15443 395962002340 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 395962002341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395962002342 Helix-turn-helix domains; Region: HTH; cl00088 395962002343 HdeA/HdeB family; Region: HdeA; cl05752 395962002344 2-isopropylmalate synthase; Validated; Region: PRK00915 395962002345 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 395962002346 active site 395962002347 catalytic residues [active] 395962002348 metal binding site [ion binding]; metal-binding site 395962002349 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 395962002350 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 395962002351 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 395962002352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002353 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962002354 putative active site [active] 395962002355 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962002356 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 395962002357 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 395962002358 Protein of unknown function (DUF433); Region: DUF433; cl01030 395962002359 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 395962002360 transketolase; Region: PLN02790 395962002361 TPP-binding site [chemical binding]; other site 395962002362 dimer interface [polypeptide binding]; other site 395962002363 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 395962002364 PYR/PP interface [polypeptide binding]; other site 395962002365 dimer interface [polypeptide binding]; other site 395962002366 TPP binding site [chemical binding]; other site 395962002367 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395962002368 glycogen synthase; Provisional; Region: glgA; PRK00654 395962002369 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 395962002370 ADP-binding pocket [chemical binding]; other site 395962002371 homodimer interface [polypeptide binding]; other site 395962002372 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 395962002373 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 395962002374 active site 395962002375 interdomain interaction site; other site 395962002376 putative metal-binding site [ion binding]; other site 395962002377 nucleotide binding site [chemical binding]; other site 395962002378 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 395962002379 domain I; other site 395962002380 phosphate binding site [ion binding]; other site 395962002381 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 395962002382 domain II; other site 395962002383 domain III; other site 395962002384 nucleotide binding site [chemical binding]; other site 395962002385 DNA binding groove [nucleotide binding] 395962002386 catalytic site [active] 395962002387 domain IV; other site 395962002388 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 395962002389 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 395962002390 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 395962002391 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 395962002392 light-harvesting-like protein 3; Provisional; Region: PLN00014 395962002393 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395962002394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962002395 active site 395962002396 phosphorylation site [posttranslational modification] 395962002397 intermolecular recognition site; other site 395962002398 dimerization interface [polypeptide binding]; other site 395962002399 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962002400 metal binding site [ion binding]; metal-binding site 395962002401 active site 395962002402 I-site; other site 395962002403 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962002404 Photosystem I protein M (PsaM); Region: PsaM; cl15374 395962002405 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962002406 YcfA-like protein; Region: YcfA; cl00752 395962002407 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 395962002408 SelR domain; Region: SelR; pfam01641 395962002409 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 395962002410 C-terminal domain interface [polypeptide binding]; other site 395962002411 GSH binding site (G-site) [chemical binding]; other site 395962002412 dimer interface [polypeptide binding]; other site 395962002413 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 395962002414 N-terminal domain interface [polypeptide binding]; other site 395962002415 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962002416 putative active site [active] 395962002417 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 395962002418 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 395962002419 dimer interface [polypeptide binding]; other site 395962002420 putative anticodon binding site; other site 395962002421 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 395962002422 motif 1; other site 395962002423 active site 395962002424 motif 2; other site 395962002425 motif 3; other site 395962002426 KTSC domain; Region: KTSC; pfam13619 395962002427 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962002428 active site 395962002429 ATP binding site [chemical binding]; other site 395962002430 substrate binding site [chemical binding]; other site 395962002431 activation loop (A-loop); other site 395962002432 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962002433 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962002434 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962002435 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 395962002436 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 395962002437 active site 395962002438 Zn binding site [ion binding]; other site 395962002439 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395962002440 dimerization interface [polypeptide binding]; other site 395962002441 putative DNA binding site [nucleotide binding]; other site 395962002442 putative Zn2+ binding site [ion binding]; other site 395962002443 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 395962002444 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 395962002445 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 395962002446 P-loop, Walker A motif; other site 395962002447 Base recognition motif; other site 395962002448 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 395962002449 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 395962002450 structural tetrad; other site 395962002451 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 395962002452 homodecamer interface [polypeptide binding]; other site 395962002453 GTP cyclohydrolase I; Provisional; Region: PLN03044 395962002454 active site 395962002455 putative catalytic site residues [active] 395962002456 zinc binding site [ion binding]; other site 395962002457 GTP-CH-I/GFRP interaction surface; other site 395962002458 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 395962002459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962002460 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 395962002461 Hydrogenase formation hypA family; Region: HypD; cl12072 395962002462 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 395962002463 Fe-S metabolism associated domain; Region: SufE; cl00951 395962002464 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 395962002465 putative active site [active] 395962002466 putative metal binding site [ion binding]; other site 395962002467 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 395962002468 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 395962002469 metal binding site 2 [ion binding]; metal-binding site 395962002470 putative DNA binding helix; other site 395962002471 metal binding site 1 [ion binding]; metal-binding site 395962002472 dimer interface [polypeptide binding]; other site 395962002473 structural Zn2+ binding site [ion binding]; other site 395962002474 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962002475 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962002476 acyl-ACP reductase; Provisional; Region: PRK14982 395962002477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002478 NAD(P) binding pocket [chemical binding]; other site 395962002479 WAX2 C-terminal domain; Region: Wax2_C; pfam12076 395962002480 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 395962002481 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 395962002482 Helix-turn-helix domains; Region: HTH; cl00088 395962002483 DNA-binding site [nucleotide binding]; DNA binding site 395962002484 HrcA protein C terminal domain; Region: HrcA; pfam01628 395962002485 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 395962002486 active site residue [active] 395962002487 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 395962002488 Gram-negative bacterial tonB protein; Region: TonB; cl10048 395962002489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962002490 binding surface 395962002491 TPR repeat; Region: TPR_11; pfam13414 395962002492 TPR motif; other site 395962002493 TPR repeat; Region: TPR_11; pfam13414 395962002494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962002495 binding surface 395962002496 TPR motif; other site 395962002497 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 395962002498 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395962002499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395962002500 catalytic residue [active] 395962002501 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 395962002502 putative active site [active] 395962002503 putative metal binding site [ion binding]; other site 395962002504 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 395962002505 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 395962002506 substrate binding site [chemical binding]; other site 395962002507 ATP binding site [chemical binding]; other site 395962002508 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 395962002509 MatE; Region: MatE; cl10513 395962002510 MatE; Region: MatE; cl10513 395962002511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962002512 active site 395962002513 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395962002514 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395962002515 ligand binding site [chemical binding]; other site 395962002516 flexible hinge region; other site 395962002517 Helix-turn-helix domains; Region: HTH; cl00088 395962002518 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 395962002519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 395962002520 ABC-ATPase subunit interface; other site 395962002521 dimer interface [polypeptide binding]; other site 395962002522 putative PBP binding regions; other site 395962002523 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395962002524 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 395962002525 NAD binding site [chemical binding]; other site 395962002526 putative substrate binding site 2 [chemical binding]; other site 395962002527 putative substrate binding site 1 [chemical binding]; other site 395962002528 active site 395962002529 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 395962002530 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 395962002531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002532 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 395962002533 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 395962002534 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 395962002535 Phosphotransferase enzyme family; Region: APH; pfam01636 395962002536 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 395962002537 active site 395962002538 ATP binding site [chemical binding]; other site 395962002539 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962002540 substrate binding site [chemical binding]; other site 395962002541 alanine racemase; Reviewed; Region: alr; PRK00053 395962002542 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 395962002543 active site 395962002544 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395962002545 dimer interface [polypeptide binding]; other site 395962002546 substrate binding site [chemical binding]; other site 395962002547 catalytic residues [active] 395962002548 Predicted ATPases [General function prediction only]; Region: COG1106 395962002549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962002550 Walker A/P-loop; other site 395962002551 ATP binding site [chemical binding]; other site 395962002552 RHS Repeat; Region: RHS_repeat; cl11982 395962002553 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 395962002554 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395962002555 PYR/PP interface [polypeptide binding]; other site 395962002556 dimer interface [polypeptide binding]; other site 395962002557 TPP binding site [chemical binding]; other site 395962002558 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 395962002559 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 395962002560 TPP-binding site [chemical binding]; other site 395962002561 dimer interface [polypeptide binding]; other site 395962002562 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 395962002563 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 395962002564 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 395962002565 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962002566 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962002567 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 395962002568 Probable Catalytic site; other site 395962002569 metal-binding site 395962002570 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 395962002571 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 395962002572 Probable Catalytic site; other site 395962002573 metal-binding site 395962002574 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 395962002575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002576 NAD(P) binding site [chemical binding]; other site 395962002577 active site 395962002578 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 395962002579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962002580 S-adenosylmethionine binding site [chemical binding]; other site 395962002581 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 395962002582 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 395962002583 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 395962002584 classical (c) SDRs; Region: SDR_c; cd05233 395962002585 NAD(P) binding site [chemical binding]; other site 395962002586 active site 395962002587 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 395962002588 homodecamer interface [polypeptide binding]; other site 395962002589 GTP cyclohydrolase I; Provisional; Region: PLN03044 395962002590 active site 395962002591 putative catalytic site residues [active] 395962002592 zinc binding site [ion binding]; other site 395962002593 GTP-CH-I/GFRP interaction surface; other site 395962002594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 395962002595 FIST N domain; Region: FIST; cl10701 395962002596 FIST C domain; Region: FIST_C; pfam10442 395962002597 CP12 domain; Region: CP12; cl14670 395962002598 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 395962002599 TPR repeat; Region: TPR_11; pfam13414 395962002600 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 395962002601 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 395962002602 putative ligand binding site [chemical binding]; other site 395962002603 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 395962002604 Tubulin like; Region: Tubulin_2; pfam13809 395962002605 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 395962002606 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 395962002607 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 395962002608 active site 395962002609 putative substrate binding region [chemical binding]; other site 395962002610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 395962002611 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 395962002612 hydrolase; Region: PLN02578 395962002613 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962002614 ScpA/B protein; Region: ScpA_ScpB; cl00598 395962002615 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 395962002616 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 395962002617 active site 395962002618 Substrate binding site; other site 395962002619 Mg++ binding site; other site 395962002620 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 395962002621 putative trimer interface [polypeptide binding]; other site 395962002622 putative CoA binding site [chemical binding]; other site 395962002623 PAS fold; Region: PAS_4; pfam08448 395962002624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395962002625 GAF domain; Region: GAF; cl15785 395962002626 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962002627 metal binding site [ion binding]; metal-binding site 395962002628 active site 395962002629 I-site; other site 395962002630 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 395962002631 Chemotaxis phosphatase CheX; Region: CheX; cl15816 395962002632 Response regulator receiver domain; Region: Response_reg; pfam00072 395962002633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962002634 active site 395962002635 phosphorylation site [posttranslational modification] 395962002636 intermolecular recognition site; other site 395962002637 dimerization interface [polypeptide binding]; other site 395962002638 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395962002639 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962002640 active site 395962002641 ATP binding site [chemical binding]; other site 395962002642 substrate binding site [chemical binding]; other site 395962002643 activation loop (A-loop); other site 395962002644 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 395962002645 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 395962002646 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 395962002647 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 395962002648 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 395962002649 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 395962002650 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 395962002651 TIR domain; Region: TIR_2; cl15770 395962002652 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962002653 structural tetrad; other site 395962002654 FOG: WD40 repeat [General function prediction only]; Region: COG2319 395962002655 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962002656 structural tetrad; other site 395962002657 mercuric reductase; Validated; Region: PRK06370 395962002658 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395962002659 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395962002660 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 395962002661 AAA domain; Region: AAA_21; pfam13304 395962002662 Walker A/P-loop; other site 395962002663 ATP binding site [chemical binding]; other site 395962002664 Q-loop/lid; other site 395962002665 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 395962002666 ABC transporter signature motif; other site 395962002667 Walker B; other site 395962002668 D-loop; other site 395962002669 H-loop/switch region; other site 395962002670 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 395962002671 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 395962002672 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 395962002673 Walker A/P-loop; other site 395962002674 ATP binding site [chemical binding]; other site 395962002675 Q-loop/lid; other site 395962002676 ABC transporter signature motif; other site 395962002677 Walker B; other site 395962002678 D-loop; other site 395962002679 H-loop/switch region; other site 395962002680 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 395962002681 alanine--tRNA ligase; Region: alaS; TIGR00344 395962002682 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 395962002683 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 395962002684 oligomer interface [polypeptide binding]; other site 395962002685 active site residues [active] 395962002686 Clp protease; Region: CLP_protease; pfam00574 395962002687 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 395962002688 oligomer interface [polypeptide binding]; other site 395962002689 active site residues [active] 395962002690 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962002691 recombinase A; Provisional; Region: recA; PRK09354 395962002692 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 395962002693 hexamer interface [polypeptide binding]; other site 395962002694 Walker A motif; other site 395962002695 ATP binding site [chemical binding]; other site 395962002696 Walker B motif; other site 395962002697 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 395962002698 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 395962002699 Zn binding site [ion binding]; other site 395962002700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962002701 S-adenosylmethionine binding site [chemical binding]; other site 395962002702 TM2 domain; Region: TM2; cl00984 395962002703 Short C-terminal domain; Region: SHOCT; cl01373 395962002704 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 395962002705 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 395962002706 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962002707 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962002708 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 395962002709 shikimate kinase; Reviewed; Region: aroK; PRK00131 395962002710 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 395962002711 ADP binding site [chemical binding]; other site 395962002712 magnesium binding site [ion binding]; other site 395962002713 putative shikimate binding site; other site 395962002714 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 395962002715 Clp amino terminal domain; Region: Clp_N; pfam02861 395962002716 Clp amino terminal domain; Region: Clp_N; pfam02861 395962002717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962002718 Walker A motif; other site 395962002719 ATP binding site [chemical binding]; other site 395962002720 Walker B motif; other site 395962002721 arginine finger; other site 395962002722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962002723 Walker A motif; other site 395962002724 ATP binding site [chemical binding]; other site 395962002725 Walker B motif; other site 395962002726 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 395962002727 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 395962002728 IHF - DNA interface [nucleotide binding]; other site 395962002729 IHF dimer interface [polypeptide binding]; other site 395962002730 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 395962002731 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 395962002732 proposed catalytic triad [active] 395962002733 active site nucleophile [active] 395962002734 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 395962002735 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962002736 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962002737 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395962002738 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395962002739 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962002740 putative active site [active] 395962002741 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 395962002742 GAF domain; Region: GAF; cl15785 395962002743 GAF domain; Region: GAF_2; pfam13185 395962002744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962002745 dimer interface [polypeptide binding]; other site 395962002746 phosphorylation site [posttranslational modification] 395962002747 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395962002748 TPR repeat; Region: TPR_11; pfam13414 395962002749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962002750 binding surface 395962002751 TPR motif; other site 395962002752 TPR repeat; Region: TPR_11; pfam13414 395962002753 hypothetical protein; Provisional; Region: PRK08185 395962002754 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 395962002755 intersubunit interface [polypeptide binding]; other site 395962002756 active site 395962002757 zinc binding site [ion binding]; other site 395962002758 Na+ binding site [ion binding]; other site 395962002759 AAA domain; Region: AAA_21; pfam13304 395962002760 RloB-like protein; Region: RloB; pfam13707 395962002761 EamA-like transporter family; Region: EamA; cl01037 395962002762 EamA-like transporter family; Region: EamA; cl01037 395962002763 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 395962002764 heterotetramer interface [polypeptide binding]; other site 395962002765 active site pocket [active] 395962002766 cleavage site 395962002767 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 395962002768 putative acyl-acceptor binding pocket; other site 395962002769 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 395962002770 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 395962002771 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 395962002772 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 395962002773 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 395962002774 active site 395962002775 zinc binding site [ion binding]; other site 395962002776 Uncharacterized conserved protein [Function unknown]; Region: COG2898 395962002777 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 395962002778 Predicted integral membrane protein [Function unknown]; Region: COG0392 395962002779 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 395962002780 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962002781 Putative esterase; Region: Esterase; pfam00756 395962002782 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 395962002783 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 395962002784 chaperone protein DnaJ; Provisional; Region: PRK14299 395962002785 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395962002786 HSP70 interaction site [polypeptide binding]; other site 395962002787 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 395962002788 dimer interface [polypeptide binding]; other site 395962002789 molecular chaperone DnaK; Provisional; Region: PRK13410 395962002790 agmatine deiminase; Region: agmatine_aguA; TIGR03380 395962002791 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 395962002792 N-carbamolyputrescine amidase; Region: PLN02747 395962002793 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 395962002794 putative active site; other site 395962002795 catalytic triad [active] 395962002796 putative dimer interface [polypeptide binding]; other site 395962002797 gamma-glutamyl kinase; Provisional; Region: PRK05429 395962002798 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 395962002799 nucleotide binding site [chemical binding]; other site 395962002800 homotetrameric interface [polypeptide binding]; other site 395962002801 putative phosphate binding site [ion binding]; other site 395962002802 putative allosteric binding site; other site 395962002803 PUA domain; Region: PUA; cl00607 395962002804 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 395962002805 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 395962002806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002807 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 395962002808 putative phosphate binding site [ion binding]; other site 395962002809 putative catalytic site [active] 395962002810 active site 395962002811 metal binding site A [ion binding]; metal-binding site 395962002812 DNA binding site [nucleotide binding] 395962002813 putative AP binding site [nucleotide binding]; other site 395962002814 putative metal binding site B [ion binding]; other site 395962002815 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 395962002816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 395962002817 cofactor binding site; other site 395962002818 DNA binding site [nucleotide binding] 395962002819 substrate interaction site [chemical binding]; other site 395962002820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 395962002821 ketol-acid reductoisomerase; Provisional; Region: PRK05479 395962002822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002823 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 395962002824 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 395962002825 Transposase IS200 like; Region: Y1_Tnp; cl00848 395962002826 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 395962002827 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 395962002828 putative substrate binding site [chemical binding]; other site 395962002829 putative ATP binding site [chemical binding]; other site 395962002830 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 395962002831 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962002832 putative active site [active] 395962002833 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 395962002834 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 395962002835 dimer interface [polypeptide binding]; other site 395962002836 tetramer interface [polypeptide binding]; other site 395962002837 PYR/PP interface [polypeptide binding]; other site 395962002838 TPP binding site [chemical binding]; other site 395962002839 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 395962002840 TPP-binding site; other site 395962002841 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 395962002842 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 395962002843 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 395962002844 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 395962002845 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395962002846 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 395962002847 putative ligand binding site [chemical binding]; other site 395962002848 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962002849 dimerization interface [polypeptide binding]; other site 395962002850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962002851 PAS domain; Region: PAS_9; pfam13426 395962002852 putative active site [active] 395962002853 heme pocket [chemical binding]; other site 395962002854 chromosome segregation protein; Provisional; Region: PRK03918 395962002855 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 395962002856 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 395962002857 Fasciclin domain; Region: Fasciclin; cl02663 395962002858 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 395962002859 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 395962002860 B12 binding site [chemical binding]; other site 395962002861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962002862 FeS/SAM binding site; other site 395962002863 NADH dehydrogenase; Region: NADHdh; cl00469 395962002864 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 395962002865 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395962002866 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 395962002867 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 395962002868 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 395962002869 Fasciclin domain; Region: Fasciclin; cl02663 395962002870 DNA polymerase III subunit beta; Validated; Region: PRK05643 395962002871 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 395962002872 putative DNA binding surface [nucleotide binding]; other site 395962002873 dimer interface [polypeptide binding]; other site 395962002874 beta-clamp/clamp loader binding surface; other site 395962002875 beta-clamp/translesion DNA polymerase binding surface; other site 395962002876 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 395962002877 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962002878 Walker A/P-loop; other site 395962002879 ATP binding site [chemical binding]; other site 395962002880 Q-loop/lid; other site 395962002881 ABC transporter signature motif; other site 395962002882 Walker B; other site 395962002883 D-loop; other site 395962002884 H-loop/switch region; other site 395962002885 ABC-2 type transporter; Region: ABC2_membrane; cl11417 395962002886 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 395962002887 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 395962002888 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 395962002889 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 395962002890 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 395962002891 Walker A/P-loop; other site 395962002892 ATP binding site [chemical binding]; other site 395962002893 Q-loop/lid; other site 395962002894 ABC transporter signature motif; other site 395962002895 Walker B; other site 395962002896 D-loop; other site 395962002897 H-loop/switch region; other site 395962002898 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 395962002899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962002900 dimer interface [polypeptide binding]; other site 395962002901 conserved gate region; other site 395962002902 putative PBP binding loops; other site 395962002903 ABC-ATPase subunit interface; other site 395962002904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962002905 dimer interface [polypeptide binding]; other site 395962002906 conserved gate region; other site 395962002907 putative PBP binding loops; other site 395962002908 ABC-ATPase subunit interface; other site 395962002909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962002910 threonine synthase; Reviewed; Region: PRK06721 395962002911 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 395962002912 homodimer interface [polypeptide binding]; other site 395962002913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962002914 catalytic residue [active] 395962002915 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 395962002916 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 395962002917 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395962002918 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395962002919 Magnesium ion binding site [ion binding]; other site 395962002920 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 395962002921 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 395962002922 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 395962002923 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 395962002924 active site 395962002925 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 395962002926 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 395962002927 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 395962002928 Walker A/P-loop; other site 395962002929 ATP binding site [chemical binding]; other site 395962002930 Q-loop/lid; other site 395962002931 ABC transporter signature motif; other site 395962002932 Walker B; other site 395962002933 D-loop; other site 395962002934 H-loop/switch region; other site 395962002935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962002936 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 395962002937 putative ADP-binding pocket [chemical binding]; other site 395962002938 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962002939 putative active site [active] 395962002940 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 395962002941 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962002942 ATP binding site [chemical binding]; other site 395962002943 putative Mg++ binding site [ion binding]; other site 395962002944 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395962002945 nucleotide binding region [chemical binding]; other site 395962002946 ATP-binding site [chemical binding]; other site 395962002947 RQC domain; Region: RQC; cl09632 395962002948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 395962002949 HRDC domain; Region: HRDC; cl02578 395962002950 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 395962002951 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 395962002952 hinge; other site 395962002953 active site 395962002954 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962002955 Putative esterase; Region: Esterase; pfam00756 395962002956 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 395962002957 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 395962002958 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 395962002959 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 395962002960 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 395962002961 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 395962002962 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 395962002963 active site 395962002964 catalytic site [active] 395962002965 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 395962002966 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 395962002967 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 395962002968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962002969 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 395962002970 integral membrane protein MviN; Region: mviN; TIGR01695 395962002971 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 395962002972 RNA/DNA binding site [nucleotide binding]; other site 395962002973 RRM dimerization site [polypeptide binding]; other site 395962002974 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 395962002975 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 395962002976 Heme NO binding; Region: HNOB; cl15268 395962002977 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 395962002978 Heme NO binding; Region: HNOB; cl15268 395962002979 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 395962002980 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 395962002981 Phycobilisome protein; Region: Phycobilisome; cl08227 395962002982 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395962002983 catalytic loop [active] 395962002984 iron binding site [ion binding]; other site 395962002985 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 395962002986 TPR repeat; Region: TPR_11; pfam13414 395962002987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962002988 binding surface 395962002989 TPR motif; other site 395962002990 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 395962002991 Mrr N-terminal domain; Region: Mrr_N; pfam14338 395962002992 Restriction endonuclease; Region: Mrr_cat; cl00516 395962002993 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395962002994 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 395962002995 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395962002996 catalytic residue [active] 395962002997 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 395962002998 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 395962002999 homodimer interface [polypeptide binding]; other site 395962003000 oligonucleotide binding site [chemical binding]; other site 395962003001 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 395962003002 RNA/DNA hybrid binding site [nucleotide binding]; other site 395962003003 active site 395962003004 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 395962003005 prephenate dehydratase; Provisional; Region: PRK11898 395962003006 Prephenate dehydratase; Region: PDT; pfam00800 395962003007 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 395962003008 putative L-Phe binding site [chemical binding]; other site 395962003009 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 395962003010 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 395962003011 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 395962003012 putative active site [active] 395962003013 catalytic site [active] 395962003014 putative metal binding site [ion binding]; other site 395962003015 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 395962003016 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 395962003017 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962003018 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 395962003019 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962003020 ATP binding site [chemical binding]; other site 395962003021 putative Mg++ binding site [ion binding]; other site 395962003022 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 395962003023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962003024 nucleotide binding region [chemical binding]; other site 395962003025 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 395962003026 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 395962003027 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 395962003028 Pantoate-beta-alanine ligase; Region: PanC; cd00560 395962003029 active site 395962003030 ATP-binding site [chemical binding]; other site 395962003031 pantoate-binding site; other site 395962003032 HXXH motif; other site 395962003033 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 395962003034 CMP-binding site; other site 395962003035 The sites determining sugar specificity; other site 395962003036 yiaA/B two helix domain; Region: YiaAB; cl01759 395962003037 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 395962003038 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 395962003039 substrate binding site [chemical binding]; other site 395962003040 ATP binding site [chemical binding]; other site 395962003041 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 395962003042 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 395962003043 Predicted esterase [General function prediction only]; Region: COG0627 395962003044 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962003045 FOG: WD40-like repeat [Function unknown]; Region: COG1520 395962003046 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 395962003047 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 395962003048 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 395962003049 GIY-YIG motif/motif A; other site 395962003050 active site 395962003051 catalytic site [active] 395962003052 putative DNA binding site [nucleotide binding]; other site 395962003053 metal binding site [ion binding]; metal-binding site 395962003054 UvrB/uvrC motif; Region: UVR; pfam02151 395962003055 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 395962003056 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 395962003057 recombination protein F; Reviewed; Region: recF; PRK00064 395962003058 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 395962003059 Walker A/P-loop; other site 395962003060 ATP binding site [chemical binding]; other site 395962003061 Q-loop/lid; other site 395962003062 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962003063 ABC transporter signature motif; other site 395962003064 Walker B; other site 395962003065 D-loop; other site 395962003066 H-loop/switch region; other site 395962003067 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 395962003068 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 395962003069 tandem repeat interface [polypeptide binding]; other site 395962003070 oligomer interface [polypeptide binding]; other site 395962003071 active site residues [active] 395962003072 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 395962003073 tandem repeat interface [polypeptide binding]; other site 395962003074 oligomer interface [polypeptide binding]; other site 395962003075 active site residues [active] 395962003076 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 395962003077 active site 395962003078 catalytic triad [active] 395962003079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962003080 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962003081 Probable transposase; Region: OrfB_IS605; pfam01385 395962003082 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962003083 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962003084 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 395962003085 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 395962003086 active site 395962003087 substrate binding site [chemical binding]; other site 395962003088 cosubstrate binding site; other site 395962003089 catalytic site [active] 395962003090 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 395962003091 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 395962003092 iron-sulfur cluster [ion binding]; other site 395962003093 [2Fe-2S] cluster binding site [ion binding]; other site 395962003094 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 395962003095 Protein of unknown function (DUF760); Region: DUF760; pfam05542 395962003096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962003097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962003098 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 395962003099 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 395962003100 Cytochrome P450; Region: p450; pfam00067 395962003101 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 395962003102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 395962003103 Cupin domain; Region: Cupin_2; cl09118 395962003104 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 395962003105 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 395962003106 catalytic triad [active] 395962003107 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 395962003108 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 395962003109 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 395962003110 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 395962003111 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 395962003112 putative active site [active] 395962003113 catalytic site [active] 395962003114 putative substrate binding site [chemical binding]; other site 395962003115 NifU-like domain; Region: NifU; cl00484 395962003116 Domain of unknown function (DUF307); Region: DUF307; pfam03733 395962003117 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 395962003118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962003119 dimer interface [polypeptide binding]; other site 395962003120 conserved gate region; other site 395962003121 ABC-ATPase subunit interface; other site 395962003122 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 395962003123 methionine aminopeptidase; Provisional; Region: PRK08671 395962003124 active site 395962003125 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 395962003126 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 395962003127 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 395962003128 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395962003129 protein binding site [polypeptide binding]; other site 395962003130 glycogen synthase; Provisional; Region: glgA; PRK00654 395962003131 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 395962003132 ADP-binding pocket [chemical binding]; other site 395962003133 homodimer interface [polypeptide binding]; other site 395962003134 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395962003135 catalytic residues [active] 395962003136 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 395962003137 feedback inhibition sensing region; other site 395962003138 homohexameric interface [polypeptide binding]; other site 395962003139 nucleotide binding site [chemical binding]; other site 395962003140 N-acetyl-L-glutamate binding site [chemical binding]; other site 395962003141 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 395962003142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962003143 binding surface 395962003144 TPR motif; other site 395962003145 TPR repeat; Region: TPR_11; pfam13414 395962003146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962003147 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 395962003148 serine O-acetyltransferase; Region: cysE; TIGR01172 395962003149 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 395962003150 trimer interface [polypeptide binding]; other site 395962003151 active site 395962003152 substrate binding site [chemical binding]; other site 395962003153 CoA binding site [chemical binding]; other site 395962003154 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 395962003155 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 395962003156 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 395962003157 TPR repeat; Region: TPR_11; pfam13414 395962003158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962003159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395962003160 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 395962003161 substrate binding pocket [chemical binding]; other site 395962003162 membrane-bound complex binding site; other site 395962003163 hinge residues; other site 395962003164 Response regulator receiver domain; Region: Response_reg; pfam00072 395962003165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962003166 active site 395962003167 phosphorylation site [posttranslational modification] 395962003168 intermolecular recognition site; other site 395962003169 dimerization interface [polypeptide binding]; other site 395962003170 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962003171 metal binding site [ion binding]; metal-binding site 395962003172 active site 395962003173 I-site; other site 395962003174 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 395962003175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 395962003176 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 395962003177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003178 PAS fold; Region: PAS_3; pfam08447 395962003179 putative active site [active] 395962003180 heme pocket [chemical binding]; other site 395962003181 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 395962003182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962003183 dimer interface [polypeptide binding]; other site 395962003184 phosphorylation site [posttranslational modification] 395962003185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962003186 ATP binding site [chemical binding]; other site 395962003187 Mg2+ binding site [ion binding]; other site 395962003188 G-X-G motif; other site 395962003189 Response regulator receiver domain; Region: Response_reg; pfam00072 395962003190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962003191 active site 395962003192 phosphorylation site [posttranslational modification] 395962003193 intermolecular recognition site; other site 395962003194 dimerization interface [polypeptide binding]; other site 395962003195 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 395962003196 aspartate kinase; Provisional; Region: PRK07431 395962003197 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 395962003198 putative catalytic residues [active] 395962003199 putative nucleotide binding site [chemical binding]; other site 395962003200 putative aspartate binding site [chemical binding]; other site 395962003201 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 395962003202 putative allosteric regulatory site; other site 395962003203 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 395962003204 putative allosteric regulatory residue; other site 395962003205 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 395962003206 putative allosteric regulatory site; other site 395962003207 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 395962003208 putative allosteric regulatory residue; other site 395962003209 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 395962003210 Cupin domain; Region: Cupin_2; cl09118 395962003211 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 395962003212 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 395962003213 active site 395962003214 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962003215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962003216 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962003217 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 395962003218 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 395962003219 metal-binding site 395962003220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962003221 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 395962003222 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 395962003223 putative active site [active] 395962003224 putative metal binding site [ion binding]; other site 395962003225 CAAX protease self-immunity; Region: Abi; cl00558 395962003226 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 395962003227 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962003228 putative active site [active] 395962003229 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 395962003230 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 395962003231 GatB domain; Region: GatB_Yqey; cl11497 395962003232 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 395962003233 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 395962003234 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 395962003235 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395962003236 ligand binding site [chemical binding]; other site 395962003237 flexible hinge region; other site 395962003238 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 395962003239 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 395962003240 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 395962003241 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 395962003242 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962003243 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 395962003244 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 395962003245 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 395962003246 amidohydrolase; Region: amidohydrolases; TIGR01891 395962003247 metal binding site [ion binding]; metal-binding site 395962003248 dimer interface [polypeptide binding]; other site 395962003249 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 395962003250 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 395962003251 dimer interface [polypeptide binding]; other site 395962003252 active site 395962003253 recombination protein RecR; Reviewed; Region: recR; PRK00076 395962003254 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 395962003255 RecR protein; Region: RecR; pfam02132 395962003256 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 395962003257 putative active site [active] 395962003258 putative metal-binding site [ion binding]; other site 395962003259 tetramer interface [polypeptide binding]; other site 395962003260 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 395962003261 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 395962003262 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 395962003263 dimer interface [polypeptide binding]; other site 395962003264 motif 1; other site 395962003265 active site 395962003266 motif 2; other site 395962003267 motif 3; other site 395962003268 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 395962003269 anticodon binding site; other site 395962003270 glycerol kinase; Region: glycerol_kin; TIGR01311 395962003271 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 395962003272 N- and C-terminal domain interface [polypeptide binding]; other site 395962003273 active site 395962003274 MgATP binding site [chemical binding]; other site 395962003275 catalytic site [active] 395962003276 metal binding site [ion binding]; metal-binding site 395962003277 glycerol binding site [chemical binding]; other site 395962003278 homotetramer interface [polypeptide binding]; other site 395962003279 homodimer interface [polypeptide binding]; other site 395962003280 FBP binding site [chemical binding]; other site 395962003281 protein IIAGlc interface [polypeptide binding]; other site 395962003282 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 395962003283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962003284 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 395962003285 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 395962003286 ring oligomerisation interface [polypeptide binding]; other site 395962003287 ATP/Mg binding site [chemical binding]; other site 395962003288 stacking interactions; other site 395962003289 hinge regions; other site 395962003290 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 395962003291 DNA binding residues [nucleotide binding] 395962003292 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 395962003293 catalytic residues [active] 395962003294 catalytic nucleophile [active] 395962003295 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 395962003296 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 395962003297 DNA binding residues [nucleotide binding] 395962003298 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 395962003299 catalytic residues [active] 395962003300 catalytic nucleophile [active] 395962003301 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 395962003302 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 395962003303 DNA binding residues [nucleotide binding] 395962003304 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 395962003305 catalytic residues [active] 395962003306 catalytic nucleophile [active] 395962003307 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 395962003308 dimer interface [polypeptide binding]; other site 395962003309 ADP-ribose binding site [chemical binding]; other site 395962003310 active site 395962003311 nudix motif; other site 395962003312 metal binding site [ion binding]; metal-binding site 395962003313 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 395962003314 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 395962003315 Predicted amidohydrolase [General function prediction only]; Region: COG0388 395962003316 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 395962003317 putative active site [active] 395962003318 catalytic triad [active] 395962003319 dimer interface [polypeptide binding]; other site 395962003320 aspartate aminotransferase; Provisional; Region: PRK05957 395962003321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395962003322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962003323 homodimer interface [polypeptide binding]; other site 395962003324 catalytic residue [active] 395962003325 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395962003326 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962003327 putative active site [active] 395962003328 PemK-like protein; Region: PemK; cl00995 395962003329 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 395962003330 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 395962003331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962003332 Walker A motif; other site 395962003333 ATP binding site [chemical binding]; other site 395962003334 Walker B motif; other site 395962003335 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 395962003336 RxxxH motif; other site 395962003337 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 395962003338 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 395962003339 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962003340 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395962003341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962003342 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395962003343 catalytic loop [active] 395962003344 iron binding site [ion binding]; other site 395962003345 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 395962003346 AMP-binding enzyme; Region: AMP-binding; cl15778 395962003347 O-succinylbenzoate synthase; Provisional; Region: PRK02714 395962003348 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 395962003349 active site 395962003350 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 395962003351 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962003352 Psb28 protein; Region: Psb28; cl04326 395962003353 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 395962003354 MPT binding site; other site 395962003355 trimer interface [polypeptide binding]; other site 395962003356 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 395962003357 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 395962003358 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 395962003359 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 395962003360 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395962003361 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 395962003362 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 395962003363 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 395962003364 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 395962003365 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962003366 active site 395962003367 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 395962003368 Tetratricopeptide repeat; Region: TPR_10; pfam13374 395962003369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962003370 binding surface 395962003371 TPR motif; other site 395962003372 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962003373 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962003374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962003375 binding surface 395962003376 TPR motif; other site 395962003377 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962003378 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962003379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962003380 binding surface 395962003381 TPR motif; other site 395962003382 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962003383 Ribosome-binding factor A; Region: RBFA; cl00542 395962003384 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 395962003385 Bifunctional nuclease; Region: DNase-RNase; cl00553 395962003386 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 395962003387 Lumazine binding domain; Region: Lum_binding; pfam00677 395962003388 Lumazine binding domain; Region: Lum_binding; pfam00677 395962003389 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 395962003390 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 395962003391 Phycobilisome protein; Region: Phycobilisome; cl08227 395962003392 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 395962003393 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 395962003394 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 395962003395 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 395962003396 catalytic motif [active] 395962003397 Zn binding site [ion binding]; other site 395962003398 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 395962003399 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 395962003400 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 395962003401 E3 interaction surface; other site 395962003402 lipoyl attachment site [posttranslational modification]; other site 395962003403 e3 binding domain; Region: E3_binding; pfam02817 395962003404 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 395962003405 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 395962003406 putative active site [active] 395962003407 dimerization interface [polypeptide binding]; other site 395962003408 putative tRNAtyr binding site [nucleotide binding]; other site 395962003409 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 395962003410 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 395962003411 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 395962003412 Response regulator receiver domain; Region: Response_reg; pfam00072 395962003413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962003414 active site 395962003415 phosphorylation site [posttranslational modification] 395962003416 intermolecular recognition site; other site 395962003417 dimerization interface [polypeptide binding]; other site 395962003418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962003419 NAD(P) binding site [chemical binding]; other site 395962003420 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 395962003421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962003422 active site 395962003423 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962003424 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 395962003425 protein I interface; other site 395962003426 D2 interface; other site 395962003427 protein T interface; other site 395962003428 chlorophyll binding site; other site 395962003429 beta carotene binding site; other site 395962003430 pheophytin binding site; other site 395962003431 manganese-stabilizing polypeptide interface; other site 395962003432 CP43 interface; other site 395962003433 protein L interface; other site 395962003434 oxygen evolving complex binding site; other site 395962003435 bromide binding site; other site 395962003436 quinone binding site; other site 395962003437 Fe binding site [ion binding]; other site 395962003438 core light harvesting interface; other site 395962003439 cytochrome b559 alpha subunit interface; other site 395962003440 cytochrome c-550 interface; other site 395962003441 protein J interface; other site 395962003442 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962003443 putative active site [active] 395962003444 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 395962003445 active site 395962003446 Zn binding site [ion binding]; other site 395962003447 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 395962003448 trimer interface [polypeptide binding]; other site 395962003449 active site 395962003450 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 395962003451 trimer interface [polypeptide binding]; other site 395962003452 active site 395962003453 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 395962003454 trimer interface [polypeptide binding]; other site 395962003455 active site 395962003456 Tetrahydromethanopterin S-methyltransferase, subunit A; Region: MtrA; cl04449 395962003457 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 395962003458 dimerization interface [polypeptide binding]; other site 395962003459 active site 395962003460 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 395962003461 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962003462 dihydropteroate synthase-related protein; Region: TIGR00284 395962003463 Domain of unknown function (DUF897); Region: DUF897; cl01312 395962003464 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 395962003465 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 395962003466 TMP-binding site; other site 395962003467 ATP-binding site [chemical binding]; other site 395962003468 NifU-like domain; Region: NifU; cl00484 395962003469 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 395962003470 iron-sulfur cluster [ion binding]; other site 395962003471 [2Fe-2S] cluster binding site [ion binding]; other site 395962003472 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962003473 putative active site [active] 395962003474 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395962003475 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395962003476 P-loop; other site 395962003477 Magnesium ion binding site [ion binding]; other site 395962003478 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395962003479 Magnesium ion binding site [ion binding]; other site 395962003480 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 395962003481 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 395962003482 THUMP domain; Region: THUMP; cl12076 395962003483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962003484 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 395962003485 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 395962003486 YCII-related domain; Region: YCII; cl00999 395962003487 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962003488 GAF domain; Region: GAF; cl15785 395962003489 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962003490 GAF domain; Region: GAF; cl15785 395962003491 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 395962003492 cyclase homology domain; Region: CHD; cd07302 395962003493 nucleotidyl binding site; other site 395962003494 metal binding site [ion binding]; metal-binding site 395962003495 dimer interface [polypeptide binding]; other site 395962003496 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 395962003497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962003498 Coenzyme A binding pocket [chemical binding]; other site 395962003499 TPR repeat; Region: TPR_11; pfam13414 395962003500 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 395962003501 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 395962003502 putative ligand binding site [chemical binding]; other site 395962003503 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 395962003504 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 395962003505 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962003506 Walker A motif; other site 395962003507 ATP binding site [chemical binding]; other site 395962003508 Walker B motif; other site 395962003509 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 395962003510 lipoyl attachment site [posttranslational modification]; other site 395962003511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003512 PAS fold; Region: PAS_3; pfam08447 395962003513 putative active site [active] 395962003514 heme pocket [chemical binding]; other site 395962003515 PAS fold; Region: PAS_4; pfam08448 395962003516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003517 putative active site [active] 395962003518 heme pocket [chemical binding]; other site 395962003519 GAF domain; Region: GAF_2; pfam13185 395962003520 GAF domain; Region: GAF; cl15785 395962003521 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395962003522 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003523 putative active site [active] 395962003524 heme pocket [chemical binding]; other site 395962003525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962003526 dimer interface [polypeptide binding]; other site 395962003527 phosphorylation site [posttranslational modification] 395962003528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962003529 ATP binding site [chemical binding]; other site 395962003530 Mg2+ binding site [ion binding]; other site 395962003531 G-X-G motif; other site 395962003532 Response regulator receiver domain; Region: Response_reg; pfam00072 395962003533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962003534 active site 395962003535 phosphorylation site [posttranslational modification] 395962003536 intermolecular recognition site; other site 395962003537 dimerization interface [polypeptide binding]; other site 395962003538 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 395962003539 putative acyl-acceptor binding pocket; other site 395962003540 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 395962003541 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395962003542 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395962003543 Magnesium ion binding site [ion binding]; other site 395962003544 photosystem I subunit VII; Region: psaC; CHL00065 395962003545 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395962003546 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 395962003547 DHH family; Region: DHH; pfam01368 395962003548 DHHA1 domain; Region: DHHA1; pfam02272 395962003549 AAA domain; Region: AAA_23; pfam13476 395962003550 AAA domain; Region: AAA_21; pfam13304 395962003551 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962003552 Walker B; other site 395962003553 D-loop; other site 395962003554 H-loop/switch region; other site 395962003555 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 395962003556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962003557 Mg2+ binding site [ion binding]; other site 395962003558 G-X-G motif; other site 395962003559 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 395962003560 anchoring element; other site 395962003561 dimer interface [polypeptide binding]; other site 395962003562 ATP binding site [chemical binding]; other site 395962003563 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 395962003564 active site 395962003565 putative metal-binding site [ion binding]; other site 395962003566 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 395962003567 stage V sporulation protein K; Region: spore_V_K; TIGR02881 395962003568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962003569 Walker A motif; other site 395962003570 ATP binding site [chemical binding]; other site 395962003571 Walker B motif; other site 395962003572 arginine finger; other site 395962003573 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 395962003574 O-Antigen ligase; Region: Wzy_C; cl04850 395962003575 O-Antigen ligase; Region: Wzy_C; cl04850 395962003576 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 395962003577 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962003578 ATP binding site [chemical binding]; other site 395962003579 putative Mg++ binding site [ion binding]; other site 395962003580 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395962003581 nucleotide binding region [chemical binding]; other site 395962003582 ATP-binding site [chemical binding]; other site 395962003583 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 395962003584 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 395962003585 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 395962003586 RNA binding site [nucleotide binding]; other site 395962003587 active site 395962003588 UTRA domain; Region: UTRA; cl01230 395962003589 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 395962003590 DHH family; Region: DHH; pfam01368 395962003591 Uncharacterized conserved protein [Function unknown]; Region: COG1912 395962003592 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 395962003593 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 395962003594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 395962003595 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 395962003596 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395962003597 FlgD Ig-like domain; Region: FlgD_ig; cl15790 395962003598 Protein of unknown function (DUF433); Region: DUF433; cl01030 395962003599 TPR repeat; Region: TPR_11; pfam13414 395962003600 TPR repeat; Region: TPR_11; pfam13414 395962003601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962003602 binding surface 395962003603 TPR motif; other site 395962003604 TPR repeat; Region: TPR_11; pfam13414 395962003605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962003606 binding surface 395962003607 TPR motif; other site 395962003608 TPR repeat; Region: TPR_11; pfam13414 395962003609 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395962003610 TPR repeat; Region: TPR_11; pfam13414 395962003611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962003612 binding surface 395962003613 TPR motif; other site 395962003614 TPR repeat; Region: TPR_11; pfam13414 395962003615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962003616 binding surface 395962003617 TPR motif; other site 395962003618 TPR repeat; Region: TPR_11; pfam13414 395962003619 TPR repeat; Region: TPR_11; pfam13414 395962003620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962003621 binding surface 395962003622 TPR motif; other site 395962003623 TPR repeat; Region: TPR_11; pfam13414 395962003624 TPR repeat; Region: TPR_11; pfam13414 395962003625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962003626 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 395962003627 Conserved TM helix; Region: TM_helix; pfam05552 395962003628 Conserved TM helix; Region: TM_helix; pfam05552 395962003629 Conserved TM helix; Region: TM_helix; pfam05552 395962003630 adaptive-response sensory kinase; Validated; Region: PRK09303 395962003631 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 395962003632 tetramer interface [polypeptide binding]; other site 395962003633 dimer interface [polypeptide binding]; other site 395962003634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962003635 dimer interface [polypeptide binding]; other site 395962003636 phosphorylation site [posttranslational modification] 395962003637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962003638 ATP binding site [chemical binding]; other site 395962003639 Mg2+ binding site [ion binding]; other site 395962003640 G-X-G motif; other site 395962003641 Uncharacterized conserved protein [Function unknown]; Region: COG1543 395962003642 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 395962003643 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 395962003644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962003645 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 395962003646 iron-sulfur cluster [ion binding]; other site 395962003647 [2Fe-2S] cluster binding site [ion binding]; other site 395962003648 carotene isomerase; Region: carot_isom; TIGR02730 395962003649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962003650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 395962003651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962003652 ATP binding site [chemical binding]; other site 395962003653 Mg2+ binding site [ion binding]; other site 395962003654 G-X-G motif; other site 395962003655 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 395962003656 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962003657 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395962003658 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 395962003659 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 395962003660 Repair protein; Region: Repair_PSII; cl01535 395962003661 proton translocating ATP synthase, F1 alpha subunit; Region: atpA; TIGR00962 395962003662 YtxH-like protein; Region: YtxH; cl02079 395962003663 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 395962003664 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 395962003665 purine monophosphate binding site [chemical binding]; other site 395962003666 dimer interface [polypeptide binding]; other site 395962003667 putative catalytic residues [active] 395962003668 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 395962003669 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 395962003670 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962003671 putative active site [active] 395962003672 Cupin domain; Region: Cupin_2; cl09118 395962003673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962003674 NADH(P)-binding; Region: NAD_binding_10; pfam13460 395962003675 NAD(P) binding site [chemical binding]; other site 395962003676 active site 395962003677 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395962003678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962003679 NAD(P) binding site [chemical binding]; other site 395962003680 active site 395962003681 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962003682 putative active site [active] 395962003683 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 395962003684 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 395962003685 G1 box; other site 395962003686 GTP/Mg2+ binding site [chemical binding]; other site 395962003687 Switch I region; other site 395962003688 G2 box; other site 395962003689 Switch II region; other site 395962003690 G3 box; other site 395962003691 G4 box; other site 395962003692 G5 box; other site 395962003693 Domain of unknown function (DUF697); Region: DUF697; cl12064 395962003694 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 395962003695 RNA/DNA hybrid binding site [nucleotide binding]; other site 395962003696 active site 395962003697 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 395962003698 DNA-binding site [nucleotide binding]; DNA binding site 395962003699 RNA-binding motif; other site 395962003700 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 395962003701 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 395962003702 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 395962003703 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 395962003704 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 395962003705 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 395962003706 Zn binding site [ion binding]; other site 395962003707 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 395962003708 elongation factor G; Reviewed; Region: PRK12740 395962003709 G1 box; other site 395962003710 putative GEF interaction site [polypeptide binding]; other site 395962003711 GTP/Mg2+ binding site [chemical binding]; other site 395962003712 Switch I region; other site 395962003713 G2 box; other site 395962003714 G3 box; other site 395962003715 Switch II region; other site 395962003716 G4 box; other site 395962003717 G5 box; other site 395962003718 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 395962003719 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 395962003720 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 395962003721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962003722 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962003723 Probable transposase; Region: OrfB_IS605; pfam01385 395962003724 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962003725 Transposase IS200 like; Region: Y1_Tnp; cl00848 395962003726 Transglycosylase; Region: Transgly; cl07896 395962003727 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 395962003728 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962003729 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395962003730 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 395962003731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962003732 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962003733 Probable transposase; Region: OrfB_IS605; pfam01385 395962003734 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962003735 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962003736 GAF domain; Region: GAF; cl15785 395962003737 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962003738 phosphopeptide binding site; other site 395962003739 PAS domain S-box; Region: sensory_box; TIGR00229 395962003740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003741 putative active site [active] 395962003742 heme pocket [chemical binding]; other site 395962003743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962003744 metal binding site [ion binding]; metal-binding site 395962003745 active site 395962003746 I-site; other site 395962003747 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962003748 putative diguanylate cyclase; Provisional; Region: PRK09776 395962003749 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 395962003750 PAS domain S-box; Region: sensory_box; TIGR00229 395962003751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003752 putative active site [active] 395962003753 heme pocket [chemical binding]; other site 395962003754 hypothetical protein; Provisional; Region: PRK13560 395962003755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003756 putative active site [active] 395962003757 heme pocket [chemical binding]; other site 395962003758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003759 putative active site [active] 395962003760 heme pocket [chemical binding]; other site 395962003761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003762 putative active site [active] 395962003763 heme pocket [chemical binding]; other site 395962003764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003765 putative active site [active] 395962003766 heme pocket [chemical binding]; other site 395962003767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962003768 dimer interface [polypeptide binding]; other site 395962003769 phosphorylation site [posttranslational modification] 395962003770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962003771 ATP binding site [chemical binding]; other site 395962003772 Mg2+ binding site [ion binding]; other site 395962003773 G-X-G motif; other site 395962003774 Response regulator receiver domain; Region: Response_reg; pfam00072 395962003775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962003776 active site 395962003777 phosphorylation site [posttranslational modification] 395962003778 intermolecular recognition site; other site 395962003779 dimerization interface [polypeptide binding]; other site 395962003780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962003781 active site 395962003782 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 395962003783 phosphorylation site [posttranslational modification] 395962003784 intermolecular recognition site; other site 395962003785 dimerization interface [polypeptide binding]; other site 395962003786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962003787 putative active site [active] 395962003788 heme pocket [chemical binding]; other site 395962003789 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962003790 metal binding site [ion binding]; metal-binding site 395962003791 active site 395962003792 I-site; other site 395962003793 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962003794 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 395962003795 pseudouridine synthase; Region: TIGR00093 395962003796 active site 395962003797 CpeS-like protein; Region: CpeS; pfam09367 395962003798 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 395962003799 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 395962003800 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 395962003801 dimer interface [polypeptide binding]; other site 395962003802 motif 1; other site 395962003803 active site 395962003804 motif 2; other site 395962003805 motif 3; other site 395962003806 O-Antigen ligase; Region: Wzy_C; cl04850 395962003807 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 395962003808 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 395962003809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962003810 Coenzyme A binding pocket [chemical binding]; other site 395962003811 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 395962003812 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962003813 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 395962003814 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 395962003815 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 395962003816 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 395962003817 CAP-like domain; other site 395962003818 active site 395962003819 primary dimer interface [polypeptide binding]; other site 395962003820 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395962003821 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395962003822 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395962003823 Response regulator receiver domain; Region: Response_reg; pfam00072 395962003824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962003825 active site 395962003826 phosphorylation site [posttranslational modification] 395962003827 intermolecular recognition site; other site 395962003828 dimerization interface [polypeptide binding]; other site 395962003829 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 395962003830 Stage II sporulation protein; Region: SpoIID; pfam08486 395962003831 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962003832 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962003833 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 395962003834 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 395962003835 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 395962003836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962003837 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 395962003838 active site 395962003839 dimerization interface [polypeptide binding]; other site 395962003840 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 395962003841 MltA specific insert domain; Region: MltA; cl08398 395962003842 3D domain; Region: 3D; cl01439 395962003843 MoxR-like ATPases [General function prediction only]; Region: COG0714 395962003844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962003845 Walker A motif; other site 395962003846 ATP binding site [chemical binding]; other site 395962003847 Walker B motif; other site 395962003848 arginine finger; other site 395962003849 Cytochrome c; Region: Cytochrom_C; cl11414 395962003850 Dihaem cytochrome c; Region: DHC; pfam09626 395962003851 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962003852 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 395962003853 Amidase; Region: Amidase; cl11426 395962003854 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962003855 putative active site [active] 395962003856 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 395962003857 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 395962003858 putative active site [active] 395962003859 catalytic triad [active] 395962003860 putative dimer interface [polypeptide binding]; other site 395962003861 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395962003862 catalytic core [active] 395962003863 citrate synthase; Provisional; Region: PRK14036 395962003864 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 395962003865 dimer interface [polypeptide binding]; other site 395962003866 active site 395962003867 citrylCoA binding site [chemical binding]; other site 395962003868 oxalacetate/citrate binding site [chemical binding]; other site 395962003869 coenzyme A binding site [chemical binding]; other site 395962003870 catalytic triad [active] 395962003871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962003872 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962003873 Probable transposase; Region: OrfB_IS605; pfam01385 395962003874 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962003875 Transposase IS200 like; Region: Y1_Tnp; cl00848 395962003876 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962003877 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 395962003878 heme binding pocket [chemical binding]; other site 395962003879 heme ligand [chemical binding]; other site 395962003880 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 395962003881 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 395962003882 CpeS-like protein; Region: CpeS; pfam09367 395962003883 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 395962003884 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962003885 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962003886 putative active site [active] 395962003887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962003888 S-adenosylmethionine binding site [chemical binding]; other site 395962003889 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 395962003890 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 395962003891 putative C-terminal domain interface [polypeptide binding]; other site 395962003892 putative GSH binding site (G-site) [chemical binding]; other site 395962003893 putative dimer interface [polypeptide binding]; other site 395962003894 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 395962003895 N-terminal domain interface [polypeptide binding]; other site 395962003896 dimer interface [polypeptide binding]; other site 395962003897 substrate binding pocket (H-site) [chemical binding]; other site 395962003898 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 395962003899 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 395962003900 catalytic residues [active] 395962003901 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 395962003902 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962003903 putative active site [active] 395962003904 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 395962003905 Domain of unknown function (DUF364); Region: DUF364; pfam04016 395962003906 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 395962003907 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 395962003908 Haemolysin XhlA; Region: XhlA; pfam10779 395962003909 Peptidase family M23; Region: Peptidase_M23; pfam01551 395962003910 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 395962003911 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 395962003912 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 395962003913 catalytic site [active] 395962003914 active site 395962003915 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 395962003916 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 395962003917 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 395962003918 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 395962003919 active site 395962003920 catalytic site [active] 395962003921 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 395962003922 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 395962003923 Phosphate-starvation-inducible E; Region: PsiE; cl01264 395962003924 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 395962003925 Cytomegalovirus IE1 protein; Region: Herpes_IE1; pfam07340 395962003926 Dynamin family; Region: Dynamin_N; pfam00350 395962003927 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 395962003928 G1 box; other site 395962003929 GTP/Mg2+ binding site [chemical binding]; other site 395962003930 Switch I region; other site 395962003931 G2 box; other site 395962003932 Switch II region; other site 395962003933 G3 box; other site 395962003934 G4 box; other site 395962003935 G5 box; other site 395962003936 Domain of unknown function (DUF697); Region: DUF697; cl12064 395962003937 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 395962003938 Domain of unknown function (DUF389); Region: DUF389; cl00781 395962003939 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 395962003940 active site 395962003941 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962003942 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 395962003943 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395962003944 FAD binding domain; Region: FAD_binding_4; pfam01565 395962003945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395962003946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962003947 dimer interface [polypeptide binding]; other site 395962003948 phosphorylation site [posttranslational modification] 395962003949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962003950 ATP binding site [chemical binding]; other site 395962003951 Mg2+ binding site [ion binding]; other site 395962003952 G-X-G motif; other site 395962003953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962003954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962003955 active site 395962003956 phosphorylation site [posttranslational modification] 395962003957 intermolecular recognition site; other site 395962003958 dimerization interface [polypeptide binding]; other site 395962003959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962003960 DNA binding site [nucleotide binding] 395962003961 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 395962003962 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962003963 Clp protease ATP binding subunit; Region: clpC; CHL00095 395962003964 Clp amino terminal domain; Region: Clp_N; pfam02861 395962003965 Clp amino terminal domain; Region: Clp_N; pfam02861 395962003966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962003967 Walker A motif; other site 395962003968 ATP binding site [chemical binding]; other site 395962003969 Walker B motif; other site 395962003970 arginine finger; other site 395962003971 UvrB/uvrC motif; Region: UVR; pfam02151 395962003972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962003973 Walker A motif; other site 395962003974 ATP binding site [chemical binding]; other site 395962003975 Walker B motif; other site 395962003976 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 395962003977 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 395962003978 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 395962003979 motif 1; other site 395962003980 active site 395962003981 motif 2; other site 395962003982 motif 3; other site 395962003983 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 395962003984 putative acyl transferase; Provisional; Region: PRK10502 395962003985 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 395962003986 putative trimer interface [polypeptide binding]; other site 395962003987 putative active site [active] 395962003988 putative substrate binding site [chemical binding]; other site 395962003989 putative CoA binding site [chemical binding]; other site 395962003990 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 395962003991 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395962003992 putative metal binding site; other site 395962003993 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 395962003994 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395962003995 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962003996 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 395962003997 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 395962003998 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395962003999 PAS fold; Region: PAS_3; pfam08447 395962004000 PAS fold; Region: PAS_3; pfam08447 395962004001 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 395962004002 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962004003 GAF domain; Region: GAF; cl15785 395962004004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962004005 metal binding site [ion binding]; metal-binding site 395962004006 active site 395962004007 I-site; other site 395962004008 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 395962004009 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 395962004010 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 395962004011 synthetase active site [active] 395962004012 NTP binding site [chemical binding]; other site 395962004013 metal binding site [ion binding]; metal-binding site 395962004014 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 395962004015 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 395962004016 CrcB-like protein; Region: CRCB; cl09114 395962004017 Glutaminase; Region: Glutaminase; cl00907 395962004018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 395962004019 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395962004020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395962004021 dimer interface [polypeptide binding]; other site 395962004022 putative CheW interface [polypeptide binding]; other site 395962004023 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 395962004024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962004025 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395962004026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962004027 TPR motif; other site 395962004028 binding surface 395962004029 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962004030 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 395962004031 catalytic center binding site [active] 395962004032 ATP binding site [chemical binding]; other site 395962004033 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 395962004034 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 395962004035 dimer interface [polypeptide binding]; other site 395962004036 ADP-ribose binding site [chemical binding]; other site 395962004037 active site 395962004038 nudix motif; other site 395962004039 metal binding site [ion binding]; metal-binding site 395962004040 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 395962004041 DNA photolyase; Region: DNA_photolyase; pfam00875 395962004042 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 395962004043 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 395962004044 radical SAM enzyme, TIGR04100 family; Region: rSAM_pair_X 395962004045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962004046 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 395962004047 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962004048 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 395962004049 S-layer homology domain; Region: SLH; pfam00395 395962004050 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 395962004051 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 395962004052 FeoA domain; Region: FeoA; cl00838 395962004053 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962004054 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962004055 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 395962004056 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 395962004057 putative NAD(P) binding site [chemical binding]; other site 395962004058 putative substrate binding site [chemical binding]; other site 395962004059 catalytic Zn binding site [ion binding]; other site 395962004060 structural Zn binding site [ion binding]; other site 395962004061 dimer interface [polypeptide binding]; other site 395962004062 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962004063 Predicted membrane protein [Function unknown]; Region: COG3463 395962004064 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 395962004065 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 395962004066 putative RNA binding site [nucleotide binding]; other site 395962004067 Protein of unknown function (DUF502); Region: DUF502; cl01107 395962004068 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 395962004069 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 395962004070 putative active site [active] 395962004071 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 395962004072 Double zinc ribbon; Region: DZR; pfam12773 395962004073 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 395962004074 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 395962004075 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962004076 phosphopeptide binding site; other site 395962004077 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 395962004078 active site 395962004079 putative substrate binding region [chemical binding]; other site 395962004080 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 395962004081 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 395962004082 classical (c) SDRs; Region: SDR_c; cd05233 395962004083 NAD(P) binding site [chemical binding]; other site 395962004084 active site 395962004085 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 395962004086 Predicted ATPase [General function prediction only]; Region: COG4637 395962004087 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 395962004088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962004089 Domain of unknown function (DUF955); Region: DUF955; cl01076 395962004090 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 395962004091 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 395962004092 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 395962004093 Walker A/P-loop; other site 395962004094 ATP binding site [chemical binding]; other site 395962004095 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 395962004096 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 395962004097 ABC transporter signature motif; other site 395962004098 Walker B; other site 395962004099 D-loop; other site 395962004100 H-loop/switch region; other site 395962004101 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 395962004102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395962004103 substrate binding pocket [chemical binding]; other site 395962004104 membrane-bound complex binding site; other site 395962004105 hinge residues; other site 395962004106 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 395962004107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962004108 FeS/SAM binding site; other site 395962004109 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 395962004110 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962004111 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 395962004112 active site 395962004113 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 395962004114 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 395962004115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395962004116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962004117 homodimer interface [polypeptide binding]; other site 395962004118 catalytic residue [active] 395962004119 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 395962004120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962004121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962004122 two component system sensor kinase SsrA; Provisional; Region: PRK15347 395962004123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962004124 dimer interface [polypeptide binding]; other site 395962004125 phosphorylation site [posttranslational modification] 395962004126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962004127 ATP binding site [chemical binding]; other site 395962004128 Mg2+ binding site [ion binding]; other site 395962004129 G-X-G motif; other site 395962004130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962004131 Response regulator receiver domain; Region: Response_reg; pfam00072 395962004132 active site 395962004133 phosphorylation site [posttranslational modification] 395962004134 intermolecular recognition site; other site 395962004135 dimerization interface [polypeptide binding]; other site 395962004136 Response regulator receiver domain; Region: Response_reg; pfam00072 395962004137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962004138 active site 395962004139 phosphorylation site [posttranslational modification] 395962004140 intermolecular recognition site; other site 395962004141 dimerization interface [polypeptide binding]; other site 395962004142 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 395962004143 Response regulator receiver domain; Region: Response_reg; pfam00072 395962004144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962004145 active site 395962004146 phosphorylation site [posttranslational modification] 395962004147 intermolecular recognition site; other site 395962004148 dimerization interface [polypeptide binding]; other site 395962004149 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962004150 GAF domain; Region: GAF; cl15785 395962004151 Predicted integral membrane protein [Function unknown]; Region: COG0392 395962004152 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 395962004153 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 395962004154 Precorrin-8X methylmutase; Region: CbiC; pfam02570 395962004155 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 395962004156 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 395962004157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 395962004158 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 395962004159 Predicted permease; Region: DUF318; pfam03773 395962004160 Predicted permeases [General function prediction only]; Region: COG0701 395962004161 Bacterial Ig-like domain; Region: Big_5; cl01012 395962004162 Response regulator receiver domain; Region: Response_reg; pfam00072 395962004163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962004164 active site 395962004165 phosphorylation site [posttranslational modification] 395962004166 intermolecular recognition site; other site 395962004167 dimerization interface [polypeptide binding]; other site 395962004168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962004169 dimer interface [polypeptide binding]; other site 395962004170 phosphorylation site [posttranslational modification] 395962004171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962004172 ATP binding site [chemical binding]; other site 395962004173 Mg2+ binding site [ion binding]; other site 395962004174 G-X-G motif; other site 395962004175 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 395962004176 GAF domain; Region: GAF; cl15785 395962004177 Phytochrome region; Region: PHY; pfam00360 395962004178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962004179 dimer interface [polypeptide binding]; other site 395962004180 phosphorylation site [posttranslational modification] 395962004181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962004182 ATP binding site [chemical binding]; other site 395962004183 Mg2+ binding site [ion binding]; other site 395962004184 G-X-G motif; other site 395962004185 Response regulator receiver domain; Region: Response_reg; pfam00072 395962004186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962004187 active site 395962004188 phosphorylation site [posttranslational modification] 395962004189 intermolecular recognition site; other site 395962004190 dimerization interface [polypeptide binding]; other site 395962004191 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 395962004192 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962004193 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962004194 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 395962004195 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 395962004196 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 395962004197 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 395962004198 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 395962004199 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 395962004200 substrate binding site [chemical binding]; other site 395962004201 active site 395962004202 catalytic residues [active] 395962004203 heterodimer interface [polypeptide binding]; other site 395962004204 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 395962004205 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 395962004206 dimer interface [polypeptide binding]; other site 395962004207 decamer (pentamer of dimers) interface [polypeptide binding]; other site 395962004208 catalytic triad [active] 395962004209 peroxidatic and resolving cysteines [active] 395962004210 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 395962004211 active site 395962004212 putative DNA-binding cleft [nucleotide binding]; other site 395962004213 dimer interface [polypeptide binding]; other site 395962004214 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395962004215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962004216 active site 395962004217 phosphorylation site [posttranslational modification] 395962004218 intermolecular recognition site; other site 395962004219 dimerization interface [polypeptide binding]; other site 395962004220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962004221 dimer interface [polypeptide binding]; other site 395962004222 phosphorylation site [posttranslational modification] 395962004223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962004224 ATP binding site [chemical binding]; other site 395962004225 G-X-G motif; other site 395962004226 Cupin domain; Region: Cupin_2; cl09118 395962004227 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 395962004228 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 395962004229 generic binding surface II; other site 395962004230 ssDNA binding site; other site 395962004231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962004232 ATP binding site [chemical binding]; other site 395962004233 putative Mg++ binding site [ion binding]; other site 395962004234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395962004235 nucleotide binding region [chemical binding]; other site 395962004236 ATP-binding site [chemical binding]; other site 395962004237 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 395962004238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962004239 S-adenosylmethionine binding site [chemical binding]; other site 395962004240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962004241 S-adenosylmethionine binding site [chemical binding]; other site 395962004242 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962004243 putative active site [active] 395962004244 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 395962004245 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 395962004246 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 395962004247 putative active site [active] 395962004248 oxyanion strand; other site 395962004249 catalytic triad [active] 395962004250 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 395962004251 putative substrate binding pocket [chemical binding]; other site 395962004252 catalytic triad [active] 395962004253 AB domain interface; other site 395962004254 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 395962004255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962004256 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962004257 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 395962004258 Chain length determinant protein; Region: Wzz; cl15801 395962004259 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 395962004260 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 395962004261 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 395962004262 SLBB domain; Region: SLBB; pfam10531 395962004263 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 395962004264 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 395962004265 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 395962004266 Rubrerythrin [Energy production and conversion]; Region: COG1592 395962004267 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 395962004268 binuclear metal center [ion binding]; other site 395962004269 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 395962004270 iron binding site [ion binding]; other site 395962004271 YcfA-like protein; Region: YcfA; cl00752 395962004272 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962004273 Predicted ATPases [General function prediction only]; Region: COG1106 395962004274 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962004275 Walker A/P-loop; other site 395962004276 ATP binding site [chemical binding]; other site 395962004277 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962004278 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 395962004279 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 395962004280 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 395962004281 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 395962004282 trimer interface [polypeptide binding]; other site 395962004283 active site 395962004284 UDP-GlcNAc binding site [chemical binding]; other site 395962004285 lipid binding site [chemical binding]; lipid-binding site 395962004286 Exoribonuclease R [Transcription]; Region: VacB; COG0557 395962004287 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 395962004288 RNB domain; Region: RNB; pfam00773 395962004289 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 395962004290 RNA binding site [nucleotide binding]; other site 395962004291 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 395962004292 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 395962004293 chorismate binding enzyme; Region: Chorismate_bind; cl10555 395962004294 UbiA prenyltransferase family; Region: UbiA; cl00337 395962004295 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 395962004296 Domain of unknown function (DUF309); Region: DUF309; cl00667 395962004297 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 395962004298 RNA/DNA binding site [nucleotide binding]; other site 395962004299 RRM dimerization site [polypeptide binding]; other site 395962004300 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962004301 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 395962004302 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395962004303 NAD(P) binding site [chemical binding]; other site 395962004304 catalytic residues [active] 395962004305 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 395962004306 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 395962004307 iron-sulfur cluster [ion binding]; other site 395962004308 [2Fe-2S] cluster binding site [ion binding]; other site 395962004309 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 395962004310 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395962004311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962004312 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 395962004313 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 395962004314 elongation factor Tu; Region: tufA; CHL00071 395962004315 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 395962004316 G1 box; other site 395962004317 GEF interaction site [polypeptide binding]; other site 395962004318 GTP/Mg2+ binding site [chemical binding]; other site 395962004319 Switch I region; other site 395962004320 G2 box; other site 395962004321 G3 box; other site 395962004322 Switch II region; other site 395962004323 G4 box; other site 395962004324 G5 box; other site 395962004325 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 395962004326 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 395962004327 Antibiotic Binding Site [chemical binding]; other site 395962004328 elongation factor G; Reviewed; Region: PRK00007 395962004329 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 395962004330 G1 box; other site 395962004331 putative GEF interaction site [polypeptide binding]; other site 395962004332 GTP/Mg2+ binding site [chemical binding]; other site 395962004333 Switch I region; other site 395962004334 G2 box; other site 395962004335 G3 box; other site 395962004336 Switch II region; other site 395962004337 G4 box; other site 395962004338 G5 box; other site 395962004339 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 395962004340 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 395962004341 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 395962004342 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 395962004343 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 395962004344 S17 interaction site [polypeptide binding]; other site 395962004345 S8 interaction site; other site 395962004346 16S rRNA interaction site [nucleotide binding]; other site 395962004347 streptomycin interaction site [chemical binding]; other site 395962004348 23S rRNA interaction site [nucleotide binding]; other site 395962004349 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 395962004350 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 395962004351 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 395962004352 Transposase domain (DUF772); Region: DUF772; cl15789 395962004353 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 395962004354 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 395962004355 homotrimer interface [polypeptide binding]; other site 395962004356 Walker A motif; other site 395962004357 GTP binding site [chemical binding]; other site 395962004358 Walker B motif; other site 395962004359 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 395962004360 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 395962004361 putative active site [active] 395962004362 substrate binding site [chemical binding]; other site 395962004363 putative cosubstrate binding site; other site 395962004364 catalytic site [active] 395962004365 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 395962004366 substrate binding site [chemical binding]; other site 395962004367 DNA polymerase III subunit delta'; Validated; Region: PRK07399 395962004368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962004369 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962004370 phosphopeptide binding site; other site 395962004371 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395962004372 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 395962004373 active site 395962004374 metal binding site [ion binding]; metal-binding site 395962004375 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 395962004376 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 395962004377 metal-binding site [ion binding] 395962004378 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395962004379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962004380 active site 395962004381 motif I; other site 395962004382 motif II; other site 395962004383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962004384 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 395962004385 Peptidase family M23; Region: Peptidase_M23; pfam01551 395962004386 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 395962004387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962004388 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 395962004389 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395962004390 RNA binding surface [nucleotide binding]; other site 395962004391 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 395962004392 active site 395962004393 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 395962004394 dimer interface [polypeptide binding]; other site 395962004395 active site 395962004396 Schiff base residues; other site 395962004397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962004398 binding surface 395962004399 TPR motif; other site 395962004400 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962004402 binding surface 395962004403 TPR motif; other site 395962004404 TPR repeat; Region: TPR_11; pfam13414 395962004405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962004406 TPR motif; other site 395962004407 binding surface 395962004408 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004409 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962004411 binding surface 395962004412 TPR motif; other site 395962004413 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004414 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962004416 TPR motif; other site 395962004417 binding surface 395962004418 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004419 CHAT domain; Region: CHAT; pfam12770 395962004420 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962004422 binding surface 395962004423 TPR motif; other site 395962004424 TPR repeat; Region: TPR_11; pfam13414 395962004425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962004427 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 395962004428 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395962004429 anti sigma factor interaction site; other site 395962004430 regulatory phosphorylation site [posttranslational modification]; other site 395962004431 Bacterial sugar transferase; Region: Bac_transf; cl00939 395962004432 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 395962004433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 395962004434 Protein of unknown function (DUF721); Region: DUF721; cl02324 395962004435 flavoprotein, HI0933 family; Region: TIGR00275 395962004436 Transposase IS200 like; Region: Y1_Tnp; cl00848 395962004437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962004438 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962004439 Probable transposase; Region: OrfB_IS605; pfam01385 395962004440 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962004441 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 395962004442 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 395962004443 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 395962004444 intersubunit interface [polypeptide binding]; other site 395962004445 active site 395962004446 Zn2+ binding site [ion binding]; other site 395962004447 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395962004448 TM-ABC transporter signature motif; other site 395962004449 response regulator FixJ; Provisional; Region: fixJ; PRK09390 395962004450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962004451 active site 395962004452 phosphorylation site [posttranslational modification] 395962004453 intermolecular recognition site; other site 395962004454 dimerization interface [polypeptide binding]; other site 395962004455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395962004456 DNA binding residues [nucleotide binding] 395962004457 dimerization interface [polypeptide binding]; other site 395962004458 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 395962004459 dimer interface [polypeptide binding]; other site 395962004460 [2Fe-2S] cluster binding site [ion binding]; other site 395962004461 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 395962004462 putative lipid kinase; Reviewed; Region: PRK13057 395962004463 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 395962004464 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 395962004465 Ligand Binding Site [chemical binding]; other site 395962004466 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962004467 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 395962004468 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962004469 GAF domain; Region: GAF; cl15785 395962004470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962004471 dimer interface [polypeptide binding]; other site 395962004472 phosphorylation site [posttranslational modification] 395962004473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962004474 ATP binding site [chemical binding]; other site 395962004475 Mg2+ binding site [ion binding]; other site 395962004476 G-X-G motif; other site 395962004477 ABC-2 type transporter; Region: ABC2_membrane; cl11417 395962004478 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 395962004479 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 395962004480 C-terminal peptidase (prc); Region: prc; TIGR00225 395962004481 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 395962004482 protein binding site [polypeptide binding]; other site 395962004483 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 395962004484 Catalytic dyad [active] 395962004485 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 395962004486 nudix motif; other site 395962004487 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 395962004488 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 395962004489 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 395962004490 homodimer interface [polypeptide binding]; other site 395962004491 NADP binding site [chemical binding]; other site 395962004492 substrate binding site [chemical binding]; other site 395962004493 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 395962004494 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 395962004495 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 395962004496 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 395962004497 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 395962004498 Hexamer interface [polypeptide binding]; other site 395962004499 Hexagonal pore residue; other site 395962004500 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 395962004501 Hexamer interface [polypeptide binding]; other site 395962004502 Hexagonal pore residue; other site 395962004503 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 395962004504 Hexamer/Pentamer interface [polypeptide binding]; other site 395962004505 central pore; other site 395962004506 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 395962004507 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 395962004508 trimer interface [polypeptide binding]; other site 395962004509 active site 395962004510 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 395962004511 putative multimerization interface [polypeptide binding]; other site 395962004512 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 395962004513 putative multimerization interface [polypeptide binding]; other site 395962004514 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 395962004515 putative multimerization interface [polypeptide binding]; other site 395962004516 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 395962004517 putative multimerization interface [polypeptide binding]; other site 395962004518 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 395962004519 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962004520 putative active site [active] 395962004521 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 395962004522 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 395962004523 homodimer interface [polypeptide binding]; other site 395962004524 active site 395962004525 heterodimer interface [polypeptide binding]; other site 395962004526 catalytic residue [active] 395962004527 metal binding site [ion binding]; metal-binding site 395962004528 RbcX protein; Region: RcbX; pfam02341 395962004529 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 395962004530 multimerization interface [polypeptide binding]; other site 395962004531 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395962004532 oligomeric interface; other site 395962004533 putative active site [active] 395962004534 homodimer interface [polypeptide binding]; other site 395962004535 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 395962004536 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962004537 alanine dehydrogenase; Region: alaDH; TIGR00518 395962004538 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 395962004539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962004540 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 395962004541 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 395962004542 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 395962004543 Walker A motif; other site 395962004544 ATP binding site [chemical binding]; other site 395962004545 Walker B motif; other site 395962004546 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 395962004547 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 395962004548 Walker A motif; other site 395962004549 ATP binding site [chemical binding]; other site 395962004550 Walker B motif; other site 395962004551 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 395962004552 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 395962004553 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 395962004554 Uncharacterized conserved protein [Function unknown]; Region: COG2006 395962004555 Domain of unknown function (DUF362); Region: DUF362; pfam04015 395962004556 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962004557 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 395962004558 classical (c) SDRs; Region: SDR_c; cd05233 395962004559 NAD(P) binding site [chemical binding]; other site 395962004560 active site 395962004561 muropeptide transporter; Validated; Region: ampG; PRK11010 395962004562 AmpG-related permease; Region: 2A0125; TIGR00901 395962004563 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 395962004564 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 395962004565 substrate binding site [chemical binding]; other site 395962004566 hexamer interface [polypeptide binding]; other site 395962004567 metal binding site [ion binding]; metal-binding site 395962004568 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962004569 putative active site [active] 395962004570 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 395962004571 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 395962004572 Fatty acid desaturase; Region: FA_desaturase; pfam00487 395962004573 putative di-iron ligands [ion binding]; other site 395962004574 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 395962004575 polyphosphate kinase; Provisional; Region: PRK05443 395962004576 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 395962004577 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 395962004578 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 395962004579 putative domain interface [polypeptide binding]; other site 395962004580 putative active site [active] 395962004581 catalytic site [active] 395962004582 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 395962004583 putative domain interface [polypeptide binding]; other site 395962004584 putative active site [active] 395962004585 catalytic site [active] 395962004586 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395962004587 catalytic loop [active] 395962004588 iron binding site [ion binding]; other site 395962004589 cobyric acid synthase; Provisional; Region: PRK00784 395962004590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962004591 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962004592 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 395962004593 catalytic triad [active] 395962004594 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 395962004595 catalytic triad [active] 395962004596 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962004597 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 395962004598 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 395962004599 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 395962004600 Substrate binding site; other site 395962004601 Mg++ binding site; other site 395962004602 metal-binding site 395962004603 Mg++ binding site; other site 395962004604 metal-binding site 395962004605 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 395962004606 Tetramer interface [polypeptide binding]; other site 395962004607 active site 395962004608 FMN-binding site [chemical binding]; other site 395962004609 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962004610 phosphopeptide binding site; other site 395962004611 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962004612 phosphopeptide binding site; other site 395962004613 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 395962004614 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395962004615 Walker A/P-loop; other site 395962004616 ATP binding site [chemical binding]; other site 395962004617 Q-loop/lid; other site 395962004618 ABC transporter signature motif; other site 395962004619 Walker B; other site 395962004620 D-loop; other site 395962004621 H-loop/switch region; other site 395962004622 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 395962004623 ferredoxin-sulfite reductase; Region: sir; TIGR02042 395962004624 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395962004625 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395962004626 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 395962004627 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 395962004628 MgtE intracellular N domain; Region: MgtE_N; cl15244 395962004629 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 395962004630 Divalent cation transporter; Region: MgtE; cl00786 395962004631 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962004632 structural tetrad; other site 395962004633 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 395962004634 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 395962004635 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 395962004636 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 395962004637 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 395962004638 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 395962004639 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 395962004640 thioester formation/cholesterol transfer; other site 395962004641 protein-splicing catalytic site; other site 395962004642 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 395962004643 HNH endonuclease; Region: HNH_3; pfam13392 395962004644 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 395962004645 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 395962004646 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 395962004647 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 395962004648 [2Fe-2S] cluster binding site [ion binding]; other site 395962004649 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 395962004650 hydrophobic ligand binding site; other site 395962004651 arginine decarboxylase; Provisional; Region: PRK05354 395962004652 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 395962004653 dimer interface [polypeptide binding]; other site 395962004654 active site 395962004655 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395962004656 catalytic residues [active] 395962004657 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 395962004658 YcfA-like protein; Region: YcfA; cl00752 395962004659 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962004660 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962004661 putative active site [active] 395962004662 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 395962004663 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 395962004664 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 395962004665 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 395962004666 active site 395962004667 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 395962004668 Exoribonuclease R [Transcription]; Region: VacB; COG0557 395962004669 RNB domain; Region: RNB; pfam00773 395962004670 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 395962004671 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 395962004672 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 395962004673 FMN binding site [chemical binding]; other site 395962004674 active site 395962004675 substrate binding site [chemical binding]; other site 395962004676 catalytic residue [active] 395962004677 putative phosphoketolase; Provisional; Region: PRK05261 395962004678 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 395962004679 TPP-binding site; other site 395962004680 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 395962004681 XFP C-terminal domain; Region: XFP_C; pfam09363 395962004682 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 395962004683 catalytic triad [active] 395962004684 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 395962004685 active site 395962004686 oxyanion hole [active] 395962004687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962004688 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 395962004689 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 395962004690 dihydrodipicolinate reductase; Provisional; Region: PRK00048 395962004691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962004692 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 395962004693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962004694 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 395962004695 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 395962004696 generic binding surface II; other site 395962004697 generic binding surface I; other site 395962004698 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 395962004699 putative active site [active] 395962004700 putative catalytic site [active] 395962004701 putative Mg binding site IVb [ion binding]; other site 395962004702 putative phosphate binding site [ion binding]; other site 395962004703 putative DNA binding site [nucleotide binding]; other site 395962004704 putative Mg binding site IVa [ion binding]; other site 395962004705 Helix-turn-helix domains; Region: HTH; cl00088 395962004706 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 395962004707 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 395962004708 enolase; Provisional; Region: eno; PRK00077 395962004709 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 395962004710 dimer interface [polypeptide binding]; other site 395962004711 metal binding site [ion binding]; metal-binding site 395962004712 substrate binding pocket [chemical binding]; other site 395962004713 PUCC protein; Region: PUCC; pfam03209 395962004714 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 395962004715 phosphodiesterase; Provisional; Region: PRK12704 395962004716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 395962004717 dimerization interface [polypeptide binding]; other site 395962004718 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 395962004719 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 395962004720 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395962004721 catalytic residue [active] 395962004722 Protein of unknown function (DUF552); Region: DUF552; cl00775 395962004723 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 395962004724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962004725 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 395962004726 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 395962004727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962004728 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 395962004729 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 395962004730 Cytochrome P450; Region: p450; pfam00067 395962004731 Sugar fermentation stimulation protein; Region: SfsA; cl00647 395962004732 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962004733 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 395962004734 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 395962004735 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 395962004736 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 395962004737 FMN binding site [chemical binding]; other site 395962004738 active site 395962004739 catalytic residues [active] 395962004740 substrate binding site [chemical binding]; other site 395962004741 hydrolase, alpha/beta fold family protein; Region: PLN02824 395962004742 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 395962004743 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 395962004744 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 395962004745 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 395962004746 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 395962004747 Ligand Binding Site [chemical binding]; other site 395962004748 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395962004749 Ligand Binding Site [chemical binding]; other site 395962004750 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 395962004751 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 395962004752 GAF domain; Region: GAF_2; pfam13185 395962004753 GAF domain; Region: GAF; cl15785 395962004754 two component system sensor kinase SsrA; Provisional; Region: PRK15347 395962004755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962004756 metal binding site [ion binding]; metal-binding site 395962004757 active site 395962004758 I-site; other site 395962004759 Response regulator receiver domain; Region: Response_reg; pfam00072 395962004760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962004761 active site 395962004762 phosphorylation site [posttranslational modification] 395962004763 intermolecular recognition site; other site 395962004764 dimerization interface [polypeptide binding]; other site 395962004765 GAF domain; Region: GAF; cl15785 395962004766 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962004767 GAF domain; Region: GAF; cl15785 395962004768 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962004769 GAF domain; Region: GAF; cl15785 395962004770 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962004771 GAF domain; Region: GAF; cl15785 395962004772 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962004773 GAF domain; Region: GAF; cl15785 395962004774 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395962004775 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395962004776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962004777 dimer interface [polypeptide binding]; other site 395962004778 phosphorylation site [posttranslational modification] 395962004779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962004780 ATP binding site [chemical binding]; other site 395962004781 Mg2+ binding site [ion binding]; other site 395962004782 G-X-G motif; other site 395962004783 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 395962004784 Ycf46; Provisional; Region: ycf46; CHL00195 395962004785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962004786 Walker A motif; other site 395962004787 ATP binding site [chemical binding]; other site 395962004788 Walker B motif; other site 395962004789 arginine finger; other site 395962004790 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962004791 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 395962004792 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 395962004793 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 395962004794 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962004795 putative active site [active] 395962004796 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 395962004797 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 395962004798 Haemolytic domain; Region: Haemolytic; cl00506 395962004799 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 395962004800 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 395962004801 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 395962004802 C-terminal domain interface [polypeptide binding]; other site 395962004803 active site 395962004804 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 395962004805 active site 395962004806 N-terminal domain interface [polypeptide binding]; other site 395962004807 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 395962004808 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 395962004809 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 395962004810 putative metal binding site; other site 395962004811 TPR repeat; Region: TPR_11; pfam13414 395962004812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962004813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962004814 binding surface 395962004815 TPR repeat; Region: TPR_11; pfam13414 395962004816 TPR motif; other site 395962004817 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395962004818 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 395962004819 peripheral dimer interface [polypeptide binding]; other site 395962004820 core dimer interface [polypeptide binding]; other site 395962004821 L10 interface [polypeptide binding]; other site 395962004822 L11 interface [polypeptide binding]; other site 395962004823 putative EF-Tu interaction site [polypeptide binding]; other site 395962004824 putative EF-G interaction site [polypeptide binding]; other site 395962004825 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 395962004826 23S rRNA interface [nucleotide binding]; other site 395962004827 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 395962004828 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 395962004829 mRNA/rRNA interface [nucleotide binding]; other site 395962004830 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 395962004831 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 395962004832 23S rRNA interface [nucleotide binding]; other site 395962004833 L7/L12 interface [polypeptide binding]; other site 395962004834 putative thiostrepton binding site; other site 395962004835 L25 interface [polypeptide binding]; other site 395962004836 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 395962004837 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 395962004838 putative homodimer interface [polypeptide binding]; other site 395962004839 KOW motif; Region: KOW; cl00354 395962004840 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 395962004841 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 395962004842 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 395962004843 NB-ARC domain; Region: NB-ARC; pfam00931 395962004844 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004845 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962004847 binding surface 395962004848 TPR motif; other site 395962004849 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962004851 binding surface 395962004852 TPR motif; other site 395962004853 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962004854 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 395962004855 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 395962004856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962004857 catalytic residue [active] 395962004858 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 395962004859 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 395962004860 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 395962004861 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 395962004862 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 395962004863 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 395962004864 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 395962004865 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 395962004866 DNA binding site [nucleotide binding] 395962004867 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 395962004868 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 395962004869 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 395962004870 RPB12 interaction site [polypeptide binding]; other site 395962004871 RPB1 interaction site [polypeptide binding]; other site 395962004872 RPB10 interaction site [polypeptide binding]; other site 395962004873 RPB11 interaction site [polypeptide binding]; other site 395962004874 RPB3 interaction site [polypeptide binding]; other site 395962004875 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 395962004876 active site 395962004877 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 395962004878 DDE superfamily endonuclease; Region: DDE_5; cl02413 395962004879 DDE superfamily endonuclease; Region: DDE_5; cl02413 395962004880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 395962004881 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 395962004882 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 395962004883 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962004884 Walker A/P-loop; other site 395962004885 ATP binding site [chemical binding]; other site 395962004886 Q-loop/lid; other site 395962004887 ABC transporter signature motif; other site 395962004888 Walker B; other site 395962004889 D-loop; other site 395962004890 H-loop/switch region; other site 395962004891 TOBE domain; Region: TOBE_2; cl01440 395962004892 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 395962004893 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 395962004894 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 395962004895 Walker A/P-loop; other site 395962004896 ATP binding site [chemical binding]; other site 395962004897 Q-loop/lid; other site 395962004898 ABC transporter signature motif; other site 395962004899 Walker B; other site 395962004900 D-loop; other site 395962004901 H-loop/switch region; other site 395962004902 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 395962004903 Walker A/P-loop; other site 395962004904 ATP binding site [chemical binding]; other site 395962004905 Q-loop/lid; other site 395962004906 ABC transporter signature motif; other site 395962004907 Walker B; other site 395962004908 D-loop; other site 395962004909 H-loop/switch region; other site 395962004910 Cobalt transport protein; Region: CbiQ; cl00463 395962004911 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962004912 putative active site [active] 395962004913 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 395962004914 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 395962004915 putative catalytic cysteine [active] 395962004916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395962004917 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962004918 Cupin domain; Region: Cupin_2; cl09118 395962004919 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 395962004920 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 395962004921 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 395962004922 active site 395962004923 substrate binding site [chemical binding]; other site 395962004924 metal binding site [ion binding]; metal-binding site 395962004925 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 395962004926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962004927 FeS/SAM binding site; other site 395962004928 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 395962004929 Predicted ATPases [General function prediction only]; Region: COG1106 395962004930 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962004931 Walker A/P-loop; other site 395962004932 ATP binding site [chemical binding]; other site 395962004933 AAA domain; Region: AAA_21; pfam13304 395962004934 Uncharacterized conserved protein [Function unknown]; Region: COG4938 395962004935 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 395962004936 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 395962004937 ArsC family; Region: ArsC; pfam03960 395962004938 putative catalytic residues [active] 395962004939 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 395962004940 dimer interface [polypeptide binding]; other site 395962004941 [2Fe-2S] cluster binding site [ion binding]; other site 395962004942 NifT/FixU protein; Region: NifT; cl02351 395962004943 NifZ domain; Region: NifZ; pfam04319 395962004944 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 395962004945 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 395962004946 active site 395962004947 catalytic residues [active] 395962004948 metal binding site [ion binding]; metal-binding site 395962004949 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 395962004950 serine O-acetyltransferase; Region: cysE; TIGR01172 395962004951 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 395962004952 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 395962004953 trimer interface [polypeptide binding]; other site 395962004954 active site 395962004955 substrate binding site [chemical binding]; other site 395962004956 CoA binding site [chemical binding]; other site 395962004957 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 395962004958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962004959 FeS/SAM binding site; other site 395962004960 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 395962004961 ferredoxin; Validated; Region: PRK07118 395962004962 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395962004963 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 395962004964 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395962004965 catalytic residue [active] 395962004966 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 395962004967 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 395962004968 trimerization site [polypeptide binding]; other site 395962004969 active site 395962004970 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 395962004971 NifU-like domain; Region: NifU; cl00484 395962004972 nitrogenase reductase; Reviewed; Region: PRK13236 395962004973 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 395962004974 Nucleotide-binding sites [chemical binding]; other site 395962004975 Walker A motif; other site 395962004976 Switch I region of nucleotide binding site; other site 395962004977 Fe4S4 binding sites [ion binding]; other site 395962004978 Switch II region of nucleotide binding site; other site 395962004979 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 395962004980 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 395962004981 MoFe protein alpha/beta subunit interactions; other site 395962004982 Alpha subunit P cluster binding residues; other site 395962004983 FeMoco binding residues [chemical binding]; other site 395962004984 MoFe protein alpha subunit/Fe protein contacts; other site 395962004985 MoFe protein dimer/ dimer interactions; other site 395962004986 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 395962004987 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 395962004988 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 395962004989 MoFe protein beta/alpha subunit interactions; other site 395962004990 Beta subunit P cluster binding residues; other site 395962004991 MoFe protein beta subunit/Fe protein contacts; other site 395962004992 MoFe protein dimer/ dimer interactions; other site 395962004993 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 395962004994 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 395962004995 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 395962004996 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 395962004997 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 395962004998 Protein of unknown function, DUF269; Region: DUF269; cl03973 395962004999 Rop-like; Region: Rop-like; cl02247 395962005000 Nitrogen fixation protein NifW; Region: NifW; cl03935 395962005001 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 395962005002 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 395962005003 ATP binding site [chemical binding]; other site 395962005004 substrate interface [chemical binding]; other site 395962005005 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 395962005006 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395962005007 catalytic loop [active] 395962005008 iron binding site [ion binding]; other site 395962005009 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 395962005010 G1 box; other site 395962005011 GTP/Mg2+ binding site [chemical binding]; other site 395962005012 Switch I region; other site 395962005013 G2 box; other site 395962005014 G3 box; other site 395962005015 Switch II region; other site 395962005016 G4 box; other site 395962005017 G5 box; other site 395962005018 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 395962005019 Nucleoside recognition; Region: Gate; cl00486 395962005020 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 395962005021 Nucleoside recognition; Region: Gate; cl00486 395962005022 FeoA domain; Region: FeoA; cl00838 395962005023 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 395962005024 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 395962005025 Acyl transferase domain; Region: Acyl_transf_1; cl08282 395962005026 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395962005027 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 395962005028 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 395962005029 dimer interface [polypeptide binding]; other site 395962005030 active site 395962005031 CoA binding pocket [chemical binding]; other site 395962005032 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 395962005033 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 395962005034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962005035 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962005036 Protein required for attachment to host cells; Region: Host_attach; cl02398 395962005037 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395962005038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962005039 active site 395962005040 phosphorylation site [posttranslational modification] 395962005041 intermolecular recognition site; other site 395962005042 dimerization interface [polypeptide binding]; other site 395962005043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395962005044 DNA binding residues [nucleotide binding] 395962005045 dimerization interface [polypeptide binding]; other site 395962005046 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 395962005047 Protein of unknown function, DUF393; Region: DUF393; cl01136 395962005048 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962005049 PemK-like protein; Region: PemK; cl00995 395962005050 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 395962005051 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 395962005052 dimer interface [polypeptide binding]; other site 395962005053 anticodon binding site; other site 395962005054 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 395962005055 homodimer interface [polypeptide binding]; other site 395962005056 motif 1; other site 395962005057 active site 395962005058 motif 2; other site 395962005059 GAD domain; Region: GAD; pfam02938 395962005060 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 395962005061 motif 3; other site 395962005062 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 395962005063 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 395962005064 active site 395962005065 catalytic triad [active] 395962005066 oxyanion hole [active] 395962005067 MAPEG family; Region: MAPEG; cl09190 395962005068 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 395962005069 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 395962005070 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 395962005071 CHASE2 domain; Region: CHASE2; cl01732 395962005072 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 395962005073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962005074 metal binding site [ion binding]; metal-binding site 395962005075 active site 395962005076 I-site; other site 395962005077 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962005078 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 395962005079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962005080 motif II; other site 395962005081 S-adenosylmethionine synthetase; Validated; Region: PRK05250 395962005082 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 395962005083 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 395962005084 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 395962005085 MbtH-like protein; Region: MbtH; cl01279 395962005086 peptide synthase; Provisional; Region: PRK12467 395962005087 AMP-binding enzyme; Region: AMP-binding; cl15778 395962005088 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962005089 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962005090 AMP-binding enzyme; Region: AMP-binding; cl15778 395962005091 AMP-binding enzyme; Region: AMP-binding; cl15778 395962005092 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962005093 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 395962005094 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395962005095 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 395962005096 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962005097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962005098 TPR repeat; Region: TPR_11; pfam13414 395962005099 binding surface 395962005100 TPR motif; other site 395962005101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962005102 binding surface 395962005103 TPR motif; other site 395962005104 TPR repeat; Region: TPR_11; pfam13414 395962005105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962005106 binding surface 395962005107 TPR motif; other site 395962005108 TPR repeat; Region: TPR_11; pfam13414 395962005109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962005110 binding surface 395962005111 TPR motif; other site 395962005112 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 395962005113 tetramerization interface [polypeptide binding]; other site 395962005114 active site 395962005115 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395962005116 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962005117 AMP-binding enzyme; Region: AMP-binding; cl15778 395962005118 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962005119 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962005120 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 395962005121 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 395962005122 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 395962005123 metal binding site 2 [ion binding]; metal-binding site 395962005124 putative DNA binding helix; other site 395962005125 metal binding site 1 [ion binding]; metal-binding site 395962005126 dimer interface [polypeptide binding]; other site 395962005127 structural Zn2+ binding site [ion binding]; other site 395962005128 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395962005129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962005130 active site 395962005131 phosphorylation site [posttranslational modification] 395962005132 intermolecular recognition site; other site 395962005133 dimerization interface [polypeptide binding]; other site 395962005134 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 395962005135 cell division protein; Validated; Region: ftsH; CHL00176 395962005136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962005137 Walker A motif; other site 395962005138 ATP binding site [chemical binding]; other site 395962005139 Walker B motif; other site 395962005140 arginine finger; other site 395962005141 Peptidase family M41; Region: Peptidase_M41; pfam01434 395962005142 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395962005143 anti sigma factor interaction site; other site 395962005144 regulatory phosphorylation site [posttranslational modification]; other site 395962005145 Response regulator receiver domain; Region: Response_reg; pfam00072 395962005146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962005147 active site 395962005148 phosphorylation site [posttranslational modification] 395962005149 intermolecular recognition site; other site 395962005150 dimerization interface [polypeptide binding]; other site 395962005151 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 395962005152 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 395962005153 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 395962005154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 395962005155 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 395962005156 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 395962005157 active site residue [active] 395962005158 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 395962005159 active site residue [active] 395962005160 Uncharacterized conserved protein [Function unknown]; Region: COG1432 395962005161 LabA_like proteins; Region: LabA; cd10911 395962005162 putative metal binding site [ion binding]; other site 395962005163 Nitrogen regulatory protein P-II; Region: P-II; cl00412 395962005164 Nitrogen regulatory protein P-II; Region: P-II; smart00938 395962005165 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 395962005166 active site 395962005167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962005168 TPR motif; other site 395962005169 TPR repeat; Region: TPR_11; pfam13414 395962005170 binding surface 395962005171 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395962005172 active site 395962005173 NTP binding site [chemical binding]; other site 395962005174 metal binding triad [ion binding]; metal-binding site 395962005175 antibiotic binding site [chemical binding]; other site 395962005176 Protein of unknown function DUF86; Region: DUF86; cl01031 395962005177 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395962005178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962005179 TPR motif; other site 395962005180 Erythromycin esterase; Region: Erythro_esteras; pfam05139 395962005181 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395962005182 active site 395962005183 NTP binding site [chemical binding]; other site 395962005184 metal binding triad [ion binding]; metal-binding site 395962005185 antibiotic binding site [chemical binding]; other site 395962005186 Protein of unknown function DUF86; Region: DUF86; cl01031 395962005187 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962005188 putative active site [active] 395962005189 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 395962005190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962005191 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 395962005192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962005193 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962005194 Probable transposase; Region: OrfB_IS605; pfam01385 395962005195 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962005196 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962005197 putative active site [active] 395962005198 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 395962005199 Hexamer interface [polypeptide binding]; other site 395962005200 Hexagonal pore residue; other site 395962005201 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 395962005202 Hexamer interface [polypeptide binding]; other site 395962005203 Hexagonal pore residue; other site 395962005204 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395962005205 extended (e) SDRs; Region: SDR_e; cd08946 395962005206 NAD(P) binding site [chemical binding]; other site 395962005207 active site 395962005208 substrate binding site [chemical binding]; other site 395962005209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962005210 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 395962005211 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 395962005212 Walker A/P-loop; other site 395962005213 ATP binding site [chemical binding]; other site 395962005214 Q-loop/lid; other site 395962005215 ABC transporter signature motif; other site 395962005216 Walker B; other site 395962005217 D-loop; other site 395962005218 H-loop/switch region; other site 395962005219 ABC-2 type transporter; Region: ABC2_membrane; cl11417 395962005220 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 395962005221 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 395962005222 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 395962005223 P loop; other site 395962005224 Nucleotide binding site [chemical binding]; other site 395962005225 UbiA prenyltransferase family; Region: UbiA; cl00337 395962005226 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962005227 putative active site [active] 395962005228 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 395962005229 quinone interaction residues [chemical binding]; other site 395962005230 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 395962005231 active site 395962005232 catalytic residues [active] 395962005233 FMN binding site [chemical binding]; other site 395962005234 substrate binding site [chemical binding]; other site 395962005235 homoserine kinase; Provisional; Region: PRK01212 395962005236 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 395962005237 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 395962005238 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 395962005239 putative active site [active] 395962005240 PemK-like protein; Region: PemK; cl00995 395962005241 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 395962005242 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 395962005243 substrate binding site [chemical binding]; other site 395962005244 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 395962005245 substrate binding site [chemical binding]; other site 395962005246 ligand binding site [chemical binding]; other site 395962005247 AAA domain; Region: AAA_21; pfam13304 395962005248 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962005249 ABC transporter signature motif; other site 395962005250 Walker B; other site 395962005251 D-loop; other site 395962005252 H-loop/switch region; other site 395962005253 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 395962005254 Protein of unknown function (DUF433); Region: DUF433; cl01030 395962005255 Protein of unknown function (DUF433); Region: DUF433; cl01030 395962005256 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 395962005257 XisI protein; Region: XisI; pfam08869 395962005258 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 395962005259 Membrane transport protein; Region: Mem_trans; cl09117 395962005260 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962005261 putative active site [active] 395962005262 Cytochrome P450; Region: p450; pfam00067 395962005263 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 395962005264 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 395962005265 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 395962005266 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 395962005267 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962005268 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 395962005269 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 395962005270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962005271 dimer interface [polypeptide binding]; other site 395962005272 conserved gate region; other site 395962005273 putative PBP binding loops; other site 395962005274 ABC-ATPase subunit interface; other site 395962005275 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962005276 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 395962005277 dimerization interface [polypeptide binding]; other site 395962005278 putative active cleft [active] 395962005279 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 395962005280 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 395962005281 potential catalytic triad [active] 395962005282 conserved cys residue [active] 395962005283 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 395962005284 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395962005285 PYR/PP interface [polypeptide binding]; other site 395962005286 dimer interface [polypeptide binding]; other site 395962005287 TPP binding site [chemical binding]; other site 395962005288 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 395962005289 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 395962005290 TPP-binding site [chemical binding]; other site 395962005291 dimer interface [polypeptide binding]; other site 395962005292 Protein of unknown function (DUF751); Region: DUF751; pfam05421 395962005293 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 395962005294 Transposase; Region: HTH_Tnp_IS630; pfam01710 395962005295 Integrase core domain; Region: rve; cl01316 395962005296 Uncharacterized conserved protein [Function unknown]; Region: COG2308 395962005297 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 395962005298 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 395962005299 putative active site [active] 395962005300 hydroxyglutarate oxidase; Provisional; Region: PRK11728 395962005301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962005302 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005303 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962005304 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005305 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005306 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 395962005307 NADH(P)-binding; Region: NAD_binding_10; pfam13460 395962005308 NAD(P) binding site [chemical binding]; other site 395962005309 putative active site [active] 395962005310 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 395962005311 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962005312 phosphopeptide binding site; other site 395962005313 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 395962005314 Transglycosylase; Region: Transgly; cl07896 395962005315 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962005316 FtsH Extracellular; Region: FtsH_ext; pfam06480 395962005317 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 395962005318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962005319 Walker A motif; other site 395962005320 ATP binding site [chemical binding]; other site 395962005321 Walker B motif; other site 395962005322 arginine finger; other site 395962005323 Peptidase family M41; Region: Peptidase_M41; pfam01434 395962005324 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 395962005325 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962005326 active site 395962005327 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 395962005328 homotrimer interaction site [polypeptide binding]; other site 395962005329 putative active site [active] 395962005330 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 395962005331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395962005332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962005333 active site 395962005334 phosphorylation site [posttranslational modification] 395962005335 intermolecular recognition site; other site 395962005336 dimerization interface [polypeptide binding]; other site 395962005337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395962005338 DNA binding residues [nucleotide binding] 395962005339 dimerization interface [polypeptide binding]; other site 395962005340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962005341 dimer interface [polypeptide binding]; other site 395962005342 phosphorylation site [posttranslational modification] 395962005343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962005344 ATP binding site [chemical binding]; other site 395962005345 Mg2+ binding site [ion binding]; other site 395962005346 G-X-G motif; other site 395962005347 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 395962005348 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 395962005349 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395962005350 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 395962005351 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962005352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962005353 Probable transposase; Region: OrfB_IS605; pfam01385 395962005354 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962005355 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 395962005356 K+-transporting ATPase, c chain; Region: KdpC; cl00944 395962005357 Electron transfer DM13; Region: DM13; cl02735 395962005358 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 395962005359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962005360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962005361 active site 395962005362 phosphorylation site [posttranslational modification] 395962005363 intermolecular recognition site; other site 395962005364 dimerization interface [polypeptide binding]; other site 395962005365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962005366 DNA binding site [nucleotide binding] 395962005367 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 395962005368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 395962005369 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 395962005370 ATP binding site [chemical binding]; other site 395962005371 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 395962005372 Plectin/S10 domain; Region: S10_plectin; cl02102 395962005373 Protein of unknown function (DUF565); Region: DUF565; pfam04483 395962005374 D-glycerate 3-kinase; Provisional; Region: PLN03046 395962005375 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962005376 active site 395962005377 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962005378 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 395962005379 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 395962005380 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 395962005381 active site 395962005382 homodimer interface [polypeptide binding]; other site 395962005383 catalytic site [active] 395962005384 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962005385 putative active site [active] 395962005386 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 395962005387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962005388 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 395962005389 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 395962005390 Sporulation related domain; Region: SPOR; cl10051 395962005391 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 395962005392 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005393 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005394 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962005395 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005396 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962005397 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005398 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 395962005399 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 395962005400 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 395962005401 cytosine deaminase-like protein; Validated; Region: PRK07583 395962005402 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 395962005403 active site 395962005404 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 395962005405 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395962005406 Cysteine-rich domain; Region: CCG; pfam02754 395962005407 Cysteine-rich domain; Region: CCG; pfam02754 395962005408 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395962005409 FAD binding domain; Region: FAD_binding_4; pfam01565 395962005410 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 395962005411 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 395962005412 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 395962005413 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 395962005414 putative active site [active] 395962005415 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 395962005416 hypothetical protein; Provisional; Region: PRK13683 395962005417 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 395962005418 D1 interface; other site 395962005419 chlorophyll binding site; other site 395962005420 pheophytin binding site; other site 395962005421 beta carotene binding site; other site 395962005422 cytochrome b559 beta interface; other site 395962005423 quinone binding site; other site 395962005424 cytochrome b559 alpha interface; other site 395962005425 protein J interface; other site 395962005426 protein H interface; other site 395962005427 protein X interface; other site 395962005428 core light harvesting protein interface; other site 395962005429 protein L interface; other site 395962005430 CP43 interface; other site 395962005431 protein T interface; other site 395962005432 Fe binding site [ion binding]; other site 395962005433 protein M interface; other site 395962005434 Mn-stabilizing polypeptide interface; other site 395962005435 bromide binding site; other site 395962005436 cytochrome c-550 interface; other site 395962005437 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 395962005438 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 395962005439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962005440 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 395962005441 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 395962005442 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 395962005443 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395962005444 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962005445 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962005446 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 395962005447 FtsX-like permease family; Region: FtsX; cl15850 395962005448 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 395962005449 Protein of unknown function (DUF497); Region: DUF497; cl01108 395962005450 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 395962005451 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 395962005452 active site 395962005453 NTP binding site [chemical binding]; other site 395962005454 metal binding triad [ion binding]; metal-binding site 395962005455 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 395962005456 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 395962005457 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 395962005458 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 395962005459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962005460 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 395962005461 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 395962005462 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 395962005463 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 395962005464 active site 395962005465 zinc binding site [ion binding]; other site 395962005466 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962005467 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 395962005468 Phage Tail Collar Domain; Region: Collar; pfam07484 395962005469 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 395962005470 active site 395962005471 dimer interface [polypeptide binding]; other site 395962005472 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 395962005473 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395962005474 acetylornithine aminotransferase; Provisional; Region: PRK02627 395962005475 inhibitor-cofactor binding pocket; inhibition site 395962005476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962005477 catalytic residue [active] 395962005478 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 395962005479 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962005480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962005481 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 395962005482 EamA-like transporter family; Region: EamA; cl01037 395962005483 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 395962005484 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 395962005485 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 395962005486 Walker A/P-loop; other site 395962005487 ATP binding site [chemical binding]; other site 395962005488 Q-loop/lid; other site 395962005489 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 395962005490 ABC transporter signature motif; other site 395962005491 Walker B; other site 395962005492 D-loop; other site 395962005493 H-loop/switch region; other site 395962005494 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 395962005495 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 395962005496 G1 box; other site 395962005497 putative GEF interaction site [polypeptide binding]; other site 395962005498 GTP/Mg2+ binding site [chemical binding]; other site 395962005499 Switch I region; other site 395962005500 G2 box; other site 395962005501 G3 box; other site 395962005502 Switch II region; other site 395962005503 G4 box; other site 395962005504 G5 box; other site 395962005505 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 395962005506 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 395962005507 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 395962005508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962005509 motif II; other site 395962005510 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395962005511 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 395962005512 putative NAD(P) binding site [chemical binding]; other site 395962005513 active site 395962005514 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 395962005515 Ligand Binding Site [chemical binding]; other site 395962005516 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 395962005517 PLU-1-like protein; Region: PLU-1; pfam08429 395962005518 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 395962005519 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 395962005520 nudix motif; other site 395962005521 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 395962005522 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 395962005523 domain interfaces; other site 395962005524 active site 395962005525 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 395962005526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962005527 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 395962005528 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395962005529 MarC family integral membrane protein; Region: MarC; cl00919 395962005530 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 395962005531 Cytochrome c; Region: Cytochrom_C; cl11414 395962005532 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 395962005533 Stage II sporulation protein; Region: SpoIID; pfam08486 395962005534 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 395962005535 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 395962005536 protein I interface; other site 395962005537 D2 interface; other site 395962005538 protein T interface; other site 395962005539 chlorophyll binding site; other site 395962005540 beta carotene binding site; other site 395962005541 pheophytin binding site; other site 395962005542 manganese-stabilizing polypeptide interface; other site 395962005543 CP43 interface; other site 395962005544 protein L interface; other site 395962005545 oxygen evolving complex binding site; other site 395962005546 bromide binding site; other site 395962005547 quinone binding site; other site 395962005548 Fe binding site [ion binding]; other site 395962005549 core light harvesting interface; other site 395962005550 cytochrome b559 alpha subunit interface; other site 395962005551 cytochrome c-550 interface; other site 395962005552 protein J interface; other site 395962005553 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962005554 putative active site [active] 395962005555 spermine synthase; Region: PLN02823 395962005556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962005557 S-adenosylmethionine binding site [chemical binding]; other site 395962005558 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 395962005559 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 395962005560 putative catalytic cysteine [active] 395962005561 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962005562 putative active site [active] 395962005563 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 395962005564 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 395962005565 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 395962005566 Membrane protein of unknown function; Region: DUF360; cl00850 395962005567 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 395962005568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962005569 ATP binding site [chemical binding]; other site 395962005570 putative Mg++ binding site [ion binding]; other site 395962005571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395962005572 nucleotide binding region [chemical binding]; other site 395962005573 ATP-binding site [chemical binding]; other site 395962005574 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962005575 putative active site [active] 395962005576 Transcriptional regulator; Region: Transcrip_reg; cl00361 395962005577 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 395962005578 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 395962005579 putative NADP binding site [chemical binding]; other site 395962005580 putative substrate binding site [chemical binding]; other site 395962005581 active site 395962005582 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962005583 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 395962005584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962005585 Walker A/P-loop; other site 395962005586 ATP binding site [chemical binding]; other site 395962005587 Q-loop/lid; other site 395962005588 ABC transporter signature motif; other site 395962005589 Walker B; other site 395962005590 D-loop; other site 395962005591 H-loop/switch region; other site 395962005592 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 395962005593 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 395962005594 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 395962005595 putative active site [active] 395962005596 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 395962005597 active site 395962005598 putative substrate binding region [chemical binding]; other site 395962005599 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 395962005600 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 395962005601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962005602 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 395962005603 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962005604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962005605 S-adenosylmethionine binding site [chemical binding]; other site 395962005606 Response regulator receiver domain; Region: Response_reg; pfam00072 395962005607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962005608 active site 395962005609 phosphorylation site [posttranslational modification] 395962005610 intermolecular recognition site; other site 395962005611 dimerization interface [polypeptide binding]; other site 395962005612 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962005613 metal binding site [ion binding]; metal-binding site 395962005614 active site 395962005615 I-site; other site 395962005616 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 395962005617 dimer interface [polypeptide binding]; other site 395962005618 substrate binding site [chemical binding]; other site 395962005619 metal binding sites [ion binding]; metal-binding site 395962005620 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 395962005621 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 395962005622 Protein of unknown function DUF86; Region: DUF86; cl01031 395962005623 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395962005624 active site 395962005625 NTP binding site [chemical binding]; other site 395962005626 metal binding triad [ion binding]; metal-binding site 395962005627 antibiotic binding site [chemical binding]; other site 395962005628 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 395962005629 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 395962005630 trimer interface [polypeptide binding]; other site 395962005631 active site 395962005632 substrate binding site [chemical binding]; other site 395962005633 CoA binding site [chemical binding]; other site 395962005634 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 395962005635 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 395962005636 FAD binding site [chemical binding]; other site 395962005637 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 395962005638 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 395962005639 active site 395962005640 HIGH motif; other site 395962005641 dimer interface [polypeptide binding]; other site 395962005642 KMSKS motif; other site 395962005643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962005644 active site 395962005645 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 395962005646 phosphorylation site [posttranslational modification] 395962005647 intermolecular recognition site; other site 395962005648 dimerization interface [polypeptide binding]; other site 395962005649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962005650 putative active site [active] 395962005651 heme pocket [chemical binding]; other site 395962005652 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962005653 metal binding site [ion binding]; metal-binding site 395962005654 active site 395962005655 I-site; other site 395962005656 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 395962005657 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 395962005658 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 395962005659 Moco binding site; other site 395962005660 metal coordination site [ion binding]; other site 395962005661 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 395962005662 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 395962005663 NAD binding site [chemical binding]; other site 395962005664 homotetramer interface [polypeptide binding]; other site 395962005665 homodimer interface [polypeptide binding]; other site 395962005666 substrate binding site [chemical binding]; other site 395962005667 active site 395962005668 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395962005669 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 395962005670 ligand binding site [chemical binding]; other site 395962005671 flexible hinge region; other site 395962005672 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395962005673 putative switch regulator; other site 395962005674 non-specific DNA interactions [nucleotide binding]; other site 395962005675 DNA binding site [nucleotide binding] 395962005676 sequence specific DNA binding site [nucleotide binding]; other site 395962005677 putative cAMP binding site [chemical binding]; other site 395962005678 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 395962005679 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 395962005680 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 395962005681 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 395962005682 Ligand binding site; other site 395962005683 Putative Catalytic site; other site 395962005684 DXD motif; other site 395962005685 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 395962005686 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395962005687 substrate binding pocket [chemical binding]; other site 395962005688 membrane-bound complex binding site; other site 395962005689 hinge residues; other site 395962005690 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 395962005691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 395962005692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962005693 putative PBP binding loops; other site 395962005694 dimer interface [polypeptide binding]; other site 395962005695 ABC-ATPase subunit interface; other site 395962005696 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 395962005697 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 395962005698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962005699 FeS/SAM binding site; other site 395962005700 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 395962005701 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962005702 putative active site [active] 395962005703 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 395962005704 Domain of unknown function (DUF427); Region: DUF427; cl00998 395962005705 Uncharacterized conserved protein [Function unknown]; Region: COG4278 395962005706 phycobillisome linker protein; Region: apcE; CHL00091 395962005707 Phycobilisome protein; Region: Phycobilisome; cl08227 395962005708 Phycobilisome protein; Region: Phycobilisome; cl08227 395962005709 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 395962005710 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 395962005711 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 395962005712 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 395962005713 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 395962005714 dimer interface [polypeptide binding]; other site 395962005715 catalytic residue [active] 395962005716 metal binding site [ion binding]; metal-binding site 395962005717 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 395962005718 Transposase; Region: DEDD_Tnp_IS110; pfam01548 395962005719 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 395962005720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395962005721 non-specific DNA binding site [nucleotide binding]; other site 395962005722 salt bridge; other site 395962005723 sequence-specific DNA binding site [nucleotide binding]; other site 395962005724 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 395962005725 DNA binding site [nucleotide binding] 395962005726 Int/Topo IB signature motif; other site 395962005727 active site 395962005728 catalytic residues [active] 395962005729 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 395962005730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962005731 Walker A motif; other site 395962005732 ATP binding site [chemical binding]; other site 395962005733 Walker B motif; other site 395962005734 arginine finger; other site 395962005735 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 395962005736 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 395962005737 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 395962005738 putative metal binding site [ion binding]; other site 395962005739 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 395962005740 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 395962005741 putative metal binding site [ion binding]; other site 395962005742 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 395962005743 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 395962005744 putative metal binding site [ion binding]; other site 395962005745 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 395962005746 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 395962005747 active site 395962005748 Riboflavin kinase; Region: Flavokinase; cl03312 395962005749 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395962005750 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962005751 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395962005752 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962005753 active site 395962005754 ATP binding site [chemical binding]; other site 395962005755 substrate binding site [chemical binding]; other site 395962005756 activation loop (A-loop); other site 395962005757 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 395962005758 Methyltransferase domain; Region: Methyltransf_31; pfam13847 395962005759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962005760 S-adenosylmethionine binding site [chemical binding]; other site 395962005761 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl15779 395962005762 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 395962005763 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 395962005764 active site 395962005765 metal binding site [ion binding]; metal-binding site 395962005766 DNA binding site [nucleotide binding] 395962005767 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 395962005768 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 395962005769 CHASE domain; Region: CHASE; cl01369 395962005770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962005771 dimer interface [polypeptide binding]; other site 395962005772 phosphorylation site [posttranslational modification] 395962005773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962005774 ATP binding site [chemical binding]; other site 395962005775 Mg2+ binding site [ion binding]; other site 395962005776 G-X-G motif; other site 395962005777 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395962005778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962005779 active site 395962005780 phosphorylation site [posttranslational modification] 395962005781 intermolecular recognition site; other site 395962005782 dimerization interface [polypeptide binding]; other site 395962005783 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962005784 GAF domain; Region: GAF; cl15785 395962005785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962005786 dimer interface [polypeptide binding]; other site 395962005787 phosphorylation site [posttranslational modification] 395962005788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962005789 ATP binding site [chemical binding]; other site 395962005790 Mg2+ binding site [ion binding]; other site 395962005791 G-X-G motif; other site 395962005792 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 395962005793 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 395962005794 dimer interface [polypeptide binding]; other site 395962005795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962005796 catalytic residue [active] 395962005797 HupE / UreJ protein; Region: HupE_UreJ; cl01011 395962005798 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 395962005799 Sporulation and spore germination; Region: Germane; cl11253 395962005800 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 395962005801 active site 395962005802 trimer interface [polypeptide binding]; other site 395962005803 allosteric site; other site 395962005804 active site lid [active] 395962005805 hexamer (dimer of trimers) interface [polypeptide binding]; other site 395962005806 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 395962005807 GSH binding site [chemical binding]; other site 395962005808 catalytic residues [active] 395962005809 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 395962005810 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962005811 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 395962005812 Cytochrome c; Region: Cytochrom_C; cl11414 395962005813 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 395962005814 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 395962005815 NADP-binding site; other site 395962005816 homotetramer interface [polypeptide binding]; other site 395962005817 substrate binding site [chemical binding]; other site 395962005818 homodimer interface [polypeptide binding]; other site 395962005819 active site 395962005820 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 395962005821 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 395962005822 active site 395962005823 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962005824 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 395962005825 active site 395962005826 catalytic site [active] 395962005827 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 395962005828 Oxygen evolving enhancer protein 3 (PsbQ); Region: PsbQ; cl05363 395962005829 alpha/beta hydrolase fold protein; Provisional; Region: PLN03084 395962005830 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962005831 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 395962005832 primosome assembly protein PriA; Validated; Region: PRK05580 395962005833 Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396 395962005834 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 395962005835 Family description; Region: UvrD_C_2; cl15862 395962005836 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 395962005837 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 395962005838 active site 395962005839 dimer interface [polypeptide binding]; other site 395962005840 catalytic residue [active] 395962005841 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 395962005842 Ca2+ binding site [ion binding]; other site 395962005843 Membrane protein of unknown function; Region: DUF360; cl00850 395962005844 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 395962005845 OstA-like protein; Region: OstA; cl00844 395962005846 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 395962005847 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 395962005848 Walker A/P-loop; other site 395962005849 ATP binding site [chemical binding]; other site 395962005850 Q-loop/lid; other site 395962005851 ABC transporter signature motif; other site 395962005852 Walker B; other site 395962005853 D-loop; other site 395962005854 H-loop/switch region; other site 395962005855 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 395962005856 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 395962005857 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 395962005858 catalytic triad [active] 395962005859 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 395962005860 Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527 395962005861 Protein-arginine deiminase (PAD); Region: PAD; pfam03068 395962005862 Survival protein SurE; Region: SurE; cl00448 395962005863 Predicted membrane protein [Function unknown]; Region: COG3463 395962005864 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 395962005865 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 395962005866 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 395962005867 NADH(P)-binding; Region: NAD_binding_10; pfam13460 395962005868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962005869 NAD(P) binding site [chemical binding]; other site 395962005870 active site 395962005871 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 395962005872 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 395962005873 C-terminal domain interface [polypeptide binding]; other site 395962005874 GSH binding site (G-site) [chemical binding]; other site 395962005875 dimer interface [polypeptide binding]; other site 395962005876 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 395962005877 N-terminal domain interface [polypeptide binding]; other site 395962005878 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962005879 structural tetrad; other site 395962005880 malonyl-CoA synthase; Validated; Region: PRK07514 395962005881 AMP-binding enzyme; Region: AMP-binding; cl15778 395962005882 AMP-binding enzyme; Region: AMP-binding; cl15778 395962005883 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 395962005884 trimerization site [polypeptide binding]; other site 395962005885 active site 395962005886 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 395962005887 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 395962005888 Ligand binding site; other site 395962005889 metal-binding site 395962005890 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 395962005891 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 395962005892 Cytochrome P450; Region: p450; pfam00067 395962005893 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 395962005894 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 395962005895 TIR domain; Region: TIR_2; cl15770 395962005896 gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529 395962005897 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 395962005898 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 395962005899 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 395962005900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962005901 FeS/SAM binding site; other site 395962005902 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 395962005903 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 395962005904 active site 395962005905 metal binding site [ion binding]; metal-binding site 395962005906 Helix-turn-helix domains; Region: HTH; cl00088 395962005907 Winged helix-turn helix; Region: HTH_29; pfam13551 395962005908 Integrase core domain; Region: rve; cl01316 395962005909 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 395962005910 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962005911 AAA domain; Region: AAA_22; pfam13401 395962005912 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 395962005913 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 395962005914 TIGR02687 family protein; Region: TIGR02687 395962005915 PglZ domain; Region: PglZ; pfam08665 395962005916 XisI protein; Region: XisI; pfam08869 395962005917 XisH protein; Region: XisH; pfam08814 395962005918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962005919 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 395962005920 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962005921 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 395962005922 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 395962005923 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 395962005924 DNA binding residues [nucleotide binding] 395962005925 putative dimer interface [polypeptide binding]; other site 395962005926 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 395962005927 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 395962005928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962005929 binding surface 395962005930 TPR motif; other site 395962005931 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 395962005932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962005933 S-adenosylmethionine binding site [chemical binding]; other site 395962005934 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 395962005935 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 395962005936 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 395962005937 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 395962005938 dimer interface [polypeptide binding]; other site 395962005939 PYR/PP interface [polypeptide binding]; other site 395962005940 TPP binding site [chemical binding]; other site 395962005941 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 395962005942 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 395962005943 TPP-binding site [chemical binding]; other site 395962005944 dimer interface [polypeptide binding]; other site 395962005945 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962005946 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005947 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005948 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005949 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962005950 GAF domain; Region: GAF; cl15785 395962005951 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962005952 metal binding site [ion binding]; metal-binding site 395962005953 active site 395962005954 I-site; other site 395962005955 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 395962005956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962005957 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 395962005958 NAD(P) binding pocket [chemical binding]; other site 395962005959 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 395962005960 MASE1; Region: MASE1; pfam05231 395962005961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962005962 dimer interface [polypeptide binding]; other site 395962005963 phosphorylation site [posttranslational modification] 395962005964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962005965 ATP binding site [chemical binding]; other site 395962005966 Mg2+ binding site [ion binding]; other site 395962005967 G-X-G motif; other site 395962005968 Response regulator receiver domain; Region: Response_reg; pfam00072 395962005969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962005970 active site 395962005971 phosphorylation site [posttranslational modification] 395962005972 intermolecular recognition site; other site 395962005973 dimerization interface [polypeptide binding]; other site 395962005974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962005975 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 395962005976 active site 395962005977 dimer interface [polypeptide binding]; other site 395962005978 TOBE domain; Region: TOBE_2; cl01440 395962005979 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 395962005980 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962005981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962005982 dimer interface [polypeptide binding]; other site 395962005983 conserved gate region; other site 395962005984 putative PBP binding loops; other site 395962005985 ABC-ATPase subunit interface; other site 395962005986 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 395962005987 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962005988 Walker A/P-loop; other site 395962005989 ATP binding site [chemical binding]; other site 395962005990 Q-loop/lid; other site 395962005991 ABC transporter signature motif; other site 395962005992 Walker B; other site 395962005993 D-loop; other site 395962005994 H-loop/switch region; other site 395962005995 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 395962005996 SmpB-tmRNA interface; other site 395962005997 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 395962005998 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 395962005999 Peptidase family M23; Region: Peptidase_M23; pfam01551 395962006000 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962006001 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 395962006002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962006003 Coenzyme A binding pocket [chemical binding]; other site 395962006004 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 395962006005 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 395962006006 Protein HOTHEAD; Region: PLN02785 395962006007 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 395962006008 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 395962006009 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395962006010 Ligand Binding Site [chemical binding]; other site 395962006011 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395962006012 Ligand Binding Site [chemical binding]; other site 395962006013 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 395962006014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962006015 Probable transposase; Region: OrfB_IS605; pfam01385 395962006016 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962006017 SOS regulatory protein LexA; Region: lexA; TIGR00498 395962006018 Helix-turn-helix domains; Region: HTH; cl00088 395962006019 Helix-turn-helix domains; Region: HTH; cl00088 395962006020 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 395962006021 Catalytic site [active] 395962006022 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 395962006023 active site 395962006024 dinuclear metal binding site [ion binding]; other site 395962006025 dimerization interface [polypeptide binding]; other site 395962006026 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 395962006027 active site 395962006028 multimer interface [polypeptide binding]; other site 395962006029 O-Antigen ligase; Region: Wzy_C; cl04850 395962006030 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 395962006031 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962006032 active site 395962006033 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962006034 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 395962006035 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 395962006036 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 395962006037 Ligand binding site; other site 395962006038 metal-binding site 395962006039 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 395962006040 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 395962006041 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 395962006042 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 395962006043 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962006044 putative active site [active] 395962006045 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 395962006046 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 395962006047 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 395962006048 dihydroorotase; Provisional; Region: PRK07369 395962006049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395962006050 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 395962006051 active site 395962006052 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962006053 putative active site [active] 395962006054 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 395962006055 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 395962006056 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 395962006057 putative peptidoglycan binding site; other site 395962006058 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 395962006059 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 395962006060 putative peptidoglycan binding site; other site 395962006061 Peptidase family M23; Region: Peptidase_M23; pfam01551 395962006062 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 395962006063 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 395962006064 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 395962006065 DNA binding residues [nucleotide binding] 395962006066 putative dimer interface [polypeptide binding]; other site 395962006067 HsdM N-terminal domain; Region: HsdM_N; pfam12161 395962006068 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 395962006069 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 395962006070 putative active site [active] 395962006071 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962006072 YcfA-like protein; Region: YcfA; cl00752 395962006073 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 395962006074 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395962006075 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395962006076 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 395962006077 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 395962006078 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 395962006079 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962006080 Protein of unknown function DUF45; Region: DUF45; cl00636 395962006081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962006082 dimer interface [polypeptide binding]; other site 395962006083 conserved gate region; other site 395962006084 putative PBP binding loops; other site 395962006085 ABC-ATPase subunit interface; other site 395962006086 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 395962006087 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962006088 putative active site [active] 395962006089 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 395962006090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395962006091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962006092 active site 395962006093 ATP binding site [chemical binding]; other site 395962006094 substrate binding site [chemical binding]; other site 395962006095 activation loop (A-loop); other site 395962006096 aspartate aminotransferase; Provisional; Region: PRK05942 395962006097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395962006098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962006099 homodimer interface [polypeptide binding]; other site 395962006100 catalytic residue [active] 395962006101 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962006102 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 395962006103 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 395962006104 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 395962006105 Protein of unknown function (DUF512); Region: DUF512; pfam04459 395962006106 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 395962006107 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 395962006108 Walker A/P-loop; other site 395962006109 ATP binding site [chemical binding]; other site 395962006110 Q-loop/lid; other site 395962006111 ABC transporter signature motif; other site 395962006112 Walker B; other site 395962006113 D-loop; other site 395962006114 H-loop/switch region; other site 395962006115 Adenosine specific kinase; Region: Adenosine_kin; cl00796 395962006116 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 395962006117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395962006118 non-specific DNA binding site [nucleotide binding]; other site 395962006119 salt bridge; other site 395962006120 sequence-specific DNA binding site [nucleotide binding]; other site 395962006121 Sulfate transporter family; Region: Sulfate_transp; cl15842 395962006122 high affinity sulphate transporter 1; Region: sulP; TIGR00815 395962006123 Sulfate transporter family; Region: Sulfate_transp; cl15842 395962006124 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 395962006125 pyruvate kinase; Region: pyruv_kin; TIGR01064 395962006126 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 395962006127 domain interfaces; other site 395962006128 active site 395962006129 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 395962006130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006131 hydrolase, alpha/beta fold family protein; Region: PLN02679 395962006132 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962006133 HupF/HypC family; Region: HupF_HypC; cl00394 395962006134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006135 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 395962006136 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 395962006137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962006138 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 395962006139 diiron binding motif [ion binding]; other site 395962006140 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 395962006141 active site 395962006142 Preprotein translocase SecG subunit; Region: SecG; cl09123 395962006143 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 395962006144 Sulfatase; Region: Sulfatase; cl10460 395962006145 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 395962006146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962006147 dimer interface [polypeptide binding]; other site 395962006148 conserved gate region; other site 395962006149 putative PBP binding loops; other site 395962006150 ABC-ATPase subunit interface; other site 395962006151 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962006152 putative active site [active] 395962006153 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 395962006154 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 395962006155 conserved cys residue [active] 395962006156 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 395962006157 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 395962006158 peptide binding site [polypeptide binding]; other site 395962006159 dimer interface [polypeptide binding]; other site 395962006160 TIR domain; Region: TIR_2; cl15770 395962006161 GUN4-like; Region: GUN4; pfam05419 395962006162 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 395962006163 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 395962006164 glutamine binding [chemical binding]; other site 395962006165 catalytic triad [active] 395962006166 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 395962006167 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 395962006168 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 395962006169 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 395962006170 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 395962006171 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 395962006172 active site 395962006173 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 395962006174 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 395962006175 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 395962006176 Walker A/P-loop; other site 395962006177 ATP binding site [chemical binding]; other site 395962006178 Q-loop/lid; other site 395962006179 ABC transporter signature motif; other site 395962006180 Walker B; other site 395962006181 D-loop; other site 395962006182 H-loop/switch region; other site 395962006183 TOBE domain; Region: TOBE_2; cl01440 395962006184 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 395962006185 active site 395962006186 oxyanion hole [active] 395962006187 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 395962006188 NeuB family; Region: NeuB; cl00496 395962006189 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 395962006190 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 395962006191 16S/18S rRNA binding site [nucleotide binding]; other site 395962006192 S13e-L30e interaction site [polypeptide binding]; other site 395962006193 25S rRNA binding site [nucleotide binding]; other site 395962006194 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395962006195 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962006196 active site 395962006197 ATP binding site [chemical binding]; other site 395962006198 substrate binding site [chemical binding]; other site 395962006199 activation loop (A-loop); other site 395962006200 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 395962006201 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 395962006202 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 395962006203 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 395962006204 putative active site [active] 395962006205 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 395962006206 putative active site [active] 395962006207 NIL domain; Region: NIL; cl09633 395962006208 4Fe-4S binding domain; Region: Fer4; cl02805 395962006209 hypothetical protein; Provisional; Region: PRK13795 395962006210 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 395962006211 catalytic residues [active] 395962006212 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 395962006213 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 395962006214 active site 395962006215 dimer interface [polypeptide binding]; other site 395962006216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962006217 active site 395962006218 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 395962006219 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 395962006220 Protein of unknown function DUF262; Region: DUF262; cl14890 395962006221 Ycf27; Reviewed; Region: orf27; CHL00148 395962006222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962006223 active site 395962006224 phosphorylation site [posttranslational modification] 395962006225 intermolecular recognition site; other site 395962006226 dimerization interface [polypeptide binding]; other site 395962006227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962006228 DNA binding site [nucleotide binding] 395962006229 DNA repair protein RadA; Provisional; Region: PRK11823 395962006230 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 395962006231 Walker A motif/ATP binding site; other site 395962006232 ATP binding site [chemical binding]; other site 395962006233 Walker B motif; other site 395962006234 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 395962006235 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962006236 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962006237 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962006238 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962006239 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962006240 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962006241 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962006242 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 395962006243 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 395962006244 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 395962006245 cofactor binding site; other site 395962006246 DNA binding site [nucleotide binding] 395962006247 substrate interaction site [chemical binding]; other site 395962006248 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 395962006249 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 395962006250 HIGH motif; other site 395962006251 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 395962006252 active site 395962006253 KMSKS motif; other site 395962006254 ABC-2 type transporter; Region: ABC2_membrane; cl11417 395962006255 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 395962006256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962006257 Walker A/P-loop; other site 395962006258 ATP binding site [chemical binding]; other site 395962006259 Q-loop/lid; other site 395962006260 ABC transporter signature motif; other site 395962006261 Walker B; other site 395962006262 D-loop; other site 395962006263 H-loop/switch region; other site 395962006264 ABC transporter; Region: ABC_tran_2; pfam12848 395962006265 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 395962006266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962006267 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 395962006268 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 395962006269 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962006270 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 395962006271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962006272 active site 395962006273 motif I; other site 395962006274 motif II; other site 395962006275 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 395962006276 dimer interface [polypeptide binding]; other site 395962006277 active site 395962006278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006279 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 395962006280 NAD(P) binding site [chemical binding]; other site 395962006281 active site 395962006282 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 395962006283 Membrane transport protein; Region: Mem_trans; cl09117 395962006284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395962006285 dimerization interface [polypeptide binding]; other site 395962006286 putative DNA binding site [nucleotide binding]; other site 395962006287 putative Zn2+ binding site [ion binding]; other site 395962006288 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 395962006289 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 395962006290 putative NAD(P) binding site [chemical binding]; other site 395962006291 catalytic Zn binding site [ion binding]; other site 395962006292 structural Zn binding site [ion binding]; other site 395962006293 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 395962006294 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395962006295 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 395962006296 diaminopimelate epimerase; Region: PLN02536 395962006297 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 395962006298 S-layer homology domain; Region: SLH; pfam00395 395962006299 S-layer homology domain; Region: SLH; pfam00395 395962006300 S-layer homology domain; Region: SLH; pfam00395 395962006301 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 395962006302 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 395962006303 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395962006304 Helix-turn-helix domains; Region: HTH; cl00088 395962006305 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 395962006306 dimerization interface [polypeptide binding]; other site 395962006307 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395962006308 Ligand Binding Site [chemical binding]; other site 395962006309 aspartate aminotransferase; Provisional; Region: PRK05764 395962006310 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395962006311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962006312 homodimer interface [polypeptide binding]; other site 395962006313 catalytic residue [active] 395962006314 Protein of unknown function (DUF561); Region: DUF561; pfam04481 395962006315 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 395962006316 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962006317 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962006318 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 395962006319 homodimer interface [polypeptide binding]; other site 395962006320 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 395962006321 active site pocket [active] 395962006322 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 395962006323 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 395962006324 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 395962006325 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 395962006326 homodimer interface [polypeptide binding]; other site 395962006327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962006328 catalytic residue [active] 395962006329 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 395962006330 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962006331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962006332 active site 395962006333 phosphorylation site [posttranslational modification] 395962006334 intermolecular recognition site; other site 395962006335 dimerization interface [polypeptide binding]; other site 395962006336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962006337 DNA binding site [nucleotide binding] 395962006338 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 395962006339 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962006340 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 395962006341 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 395962006342 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 395962006343 G1 box; other site 395962006344 GTP/Mg2+ binding site [chemical binding]; other site 395962006345 Switch I region; other site 395962006346 G2 box; other site 395962006347 Switch II region; other site 395962006348 G3 box; other site 395962006349 G4 box; other site 395962006350 G5 box; other site 395962006351 Domain of unknown function (DUF697); Region: DUF697; cl12064 395962006352 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 395962006353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395962006355 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 395962006356 catalytic residues [active] 395962006357 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 395962006358 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 395962006359 DNA binding site [nucleotide binding] 395962006360 active site 395962006361 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 395962006362 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 395962006363 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 395962006364 nudix motif; other site 395962006365 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 395962006366 dimer interface [polypeptide binding]; other site 395962006367 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395962006368 metal binding site [ion binding]; metal-binding site 395962006369 glycogen branching enzyme; Provisional; Region: PRK12313 395962006370 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 395962006371 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 395962006372 active site 395962006373 catalytic site [active] 395962006374 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 395962006375 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 395962006376 dihydropteroate synthase; Region: DHPS; TIGR01496 395962006377 substrate binding pocket [chemical binding]; other site 395962006378 dimer interface [polypeptide binding]; other site 395962006379 inhibitor binding site; inhibition site 395962006380 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 395962006381 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395962006382 minor groove reading motif; other site 395962006383 helix-hairpin-helix signature motif; other site 395962006384 substrate binding pocket [chemical binding]; other site 395962006385 active site 395962006386 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 395962006387 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 395962006388 active site 395962006389 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 395962006390 protein binding site [polypeptide binding]; other site 395962006391 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 395962006392 2TM domain; Region: 2TM; pfam13239 395962006393 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 395962006394 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 395962006395 putative substrate binding site [chemical binding]; other site 395962006396 nucleotide binding site [chemical binding]; other site 395962006397 nucleotide binding site [chemical binding]; other site 395962006398 homodimer interface [polypeptide binding]; other site 395962006399 Predicted GTPase [General function prediction only]; Region: COG2403 395962006400 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 395962006401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962006402 active site 395962006403 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 395962006404 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395962006405 inhibitor-cofactor binding pocket; inhibition site 395962006406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962006407 catalytic residue [active] 395962006408 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 395962006409 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 395962006410 active site residue [active] 395962006411 CbiD; Region: CbiD; cl00828 395962006412 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 395962006413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962006414 Coenzyme A binding pocket [chemical binding]; other site 395962006415 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 395962006416 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 395962006417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006418 oligomerization interface [polypeptide binding]; other site 395962006419 active site 395962006420 NAD+ binding site [chemical binding]; other site 395962006421 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395962006422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962006423 active site 395962006424 phosphorylation site [posttranslational modification] 395962006425 intermolecular recognition site; other site 395962006426 dimerization interface [polypeptide binding]; other site 395962006427 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395962006428 DNA binding residues [nucleotide binding] 395962006429 dimerization interface [polypeptide binding]; other site 395962006430 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 395962006431 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 395962006432 FMN binding site [chemical binding]; other site 395962006433 active site 395962006434 catalytic residues [active] 395962006435 substrate binding site [chemical binding]; other site 395962006436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395962006437 Helix-turn-helix domains; Region: HTH; cl00088 395962006438 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 395962006439 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 395962006440 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 395962006441 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395962006442 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395962006443 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 395962006444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962006445 S-adenosylmethionine binding site [chemical binding]; other site 395962006446 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 395962006447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006448 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 395962006449 putative L-serine binding site [chemical binding]; other site 395962006450 TIR domain; Region: TIR_2; cl15770 395962006451 FOG: WD40 repeat [General function prediction only]; Region: COG2319 395962006452 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962006453 structural tetrad; other site 395962006454 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962006455 structural tetrad; other site 395962006456 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 395962006457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962006458 S-adenosylmethionine binding site [chemical binding]; other site 395962006459 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 395962006460 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 395962006461 active site flap/lid [active] 395962006462 nucleophilic elbow; other site 395962006463 catalytic triad [active] 395962006464 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 395962006465 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 395962006466 classical (c) SDRs; Region: SDR_c; cd05233 395962006467 NAD(P) binding site [chemical binding]; other site 395962006468 active site 395962006469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962006470 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962006471 conserved hypothetical protein; Region: TIGR03492 395962006472 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 395962006473 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962006474 putative active site [active] 395962006475 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 395962006476 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962006477 Abi-like protein; Region: Abi_2; cl01988 395962006478 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 395962006479 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 395962006480 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 395962006481 Walker A/P-loop; other site 395962006482 ATP binding site [chemical binding]; other site 395962006483 Q-loop/lid; other site 395962006484 ABC transporter signature motif; other site 395962006485 Walker B; other site 395962006486 D-loop; other site 395962006487 H-loop/switch region; other site 395962006488 Helix-turn-helix domains; Region: HTH; cl00088 395962006489 Winged helix-turn helix; Region: HTH_29; pfam13551 395962006490 Integrase core domain; Region: rve; cl01316 395962006491 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 395962006492 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962006493 GUN4-like; Region: GUN4; pfam05419 395962006494 PetN; Region: PetN; cl15376 395962006495 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 395962006496 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 395962006497 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962006498 Walker A/P-loop; other site 395962006499 ATP binding site [chemical binding]; other site 395962006500 14-3-3 domain; Region: 14-3-3; cl02098 395962006501 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962006502 Q-loop/lid; other site 395962006503 ABC transporter signature motif; other site 395962006504 Walker B; other site 395962006505 D-loop; other site 395962006506 H-loop/switch region; other site 395962006507 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 395962006508 Active Sites [active] 395962006509 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 395962006510 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 395962006511 DNA-sulfur modification-associated; Region: DndB; cl14002 395962006512 DNA-sulfur modification-associated; Region: DndB; cl14002 395962006513 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962006514 putative active site [active] 395962006515 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 395962006516 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 395962006517 phosphate binding site [ion binding]; other site 395962006518 putative substrate binding pocket [chemical binding]; other site 395962006519 dimer interface [polypeptide binding]; other site 395962006520 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 395962006521 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 395962006522 PemK-like protein; Region: PemK; cl00995 395962006523 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 395962006524 putative active site [active] 395962006525 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 395962006526 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 395962006527 tRNA; other site 395962006528 putative tRNA binding site [nucleotide binding]; other site 395962006529 putative NADP binding site [chemical binding]; other site 395962006530 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 395962006531 TIR domain; Region: TIR_2; cl15770 395962006532 TPR repeat; Region: TPR_11; pfam13414 395962006533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962006534 binding surface 395962006535 TPR motif; other site 395962006536 TPR repeat; Region: TPR_11; pfam13414 395962006537 TPR repeat; Region: TPR_11; pfam13414 395962006538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962006539 binding surface 395962006540 TPR motif; other site 395962006541 TPR repeat; Region: TPR_11; pfam13414 395962006542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962006543 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962006544 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 395962006545 Flavoprotein; Region: Flavoprotein; cl08021 395962006546 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 395962006547 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 395962006548 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 395962006549 Survival protein SurE; Region: SurE; cl00448 395962006550 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962006551 putative active site [active] 395962006552 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 395962006553 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 395962006554 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 395962006555 dimer interface [polypeptide binding]; other site 395962006556 motif 1; other site 395962006557 active site 395962006558 motif 2; other site 395962006559 motif 3; other site 395962006560 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 395962006561 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 395962006562 conserved cys residue [active] 395962006563 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 395962006564 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 395962006565 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 395962006566 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 395962006567 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 395962006568 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 395962006569 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 395962006570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962006571 dimer interface [polypeptide binding]; other site 395962006572 phosphorylation site [posttranslational modification] 395962006573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962006574 ATP binding site [chemical binding]; other site 395962006575 Mg2+ binding site [ion binding]; other site 395962006576 G-X-G motif; other site 395962006577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962006578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962006579 active site 395962006580 phosphorylation site [posttranslational modification] 395962006581 intermolecular recognition site; other site 395962006582 dimerization interface [polypeptide binding]; other site 395962006583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962006584 DNA binding site [nucleotide binding] 395962006585 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 395962006586 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962006587 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962006588 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962006589 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 395962006590 putative transposase; Provisional; Region: PHA02942 395962006591 Probable transposase; Region: OrfB_IS605; pfam01385 395962006592 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 395962006593 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962006594 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 395962006595 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 395962006596 DNA binding residues [nucleotide binding] 395962006597 dimer interface [polypeptide binding]; other site 395962006598 metal binding site [ion binding]; metal-binding site 395962006599 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 395962006600 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 395962006601 metal-binding site [ion binding] 395962006602 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395962006603 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 395962006604 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 395962006605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962006606 dimer interface [polypeptide binding]; other site 395962006607 conserved gate region; other site 395962006608 putative PBP binding loops; other site 395962006609 ABC-ATPase subunit interface; other site 395962006610 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 395962006611 putative catalytic residues [active] 395962006612 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 395962006613 dimer interface [polypeptide binding]; other site 395962006614 substrate binding site [chemical binding]; other site 395962006615 catalytic triad [active] 395962006616 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 395962006617 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 395962006618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962006619 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 395962006620 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962006621 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 395962006622 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 395962006623 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 395962006624 CHASE2 domain; Region: CHASE2; cl01732 395962006625 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 395962006626 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962006627 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 395962006628 Flavin Reductases; Region: FlaRed; cl00801 395962006629 Phosphate-starvation-inducible E; Region: PsiE; cl01264 395962006630 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 395962006631 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962006632 Flavin Reductases; Region: FlaRed; cl00801 395962006633 carotene isomerase; Region: carot_isom; TIGR02730 395962006634 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 395962006635 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 395962006636 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 395962006637 P loop; other site 395962006638 Nucleotide binding site [chemical binding]; other site 395962006639 DTAP/Switch II; other site 395962006640 Switch I; other site 395962006641 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 395962006642 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 395962006643 Repair protein; Region: Repair_PSII; cl01535 395962006644 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 395962006645 EamA-like transporter family; Region: EamA; cl01037 395962006646 EamA-like transporter family; Region: EamA; cl01037 395962006647 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 395962006648 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 395962006649 Protein of unknown function (DUF433); Region: DUF433; cl01030 395962006650 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 395962006651 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 395962006652 Flagellin N-methylase; Region: FliB; cl00497 395962006653 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 395962006654 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 395962006655 active site 395962006656 dimer interface [polypeptide binding]; other site 395962006657 catalytic nucleophile [active] 395962006658 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 395962006659 Acylphosphatase; Region: Acylphosphatase; cl00551 395962006660 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 395962006661 HypF finger; Region: zf-HYPF; pfam07503 395962006662 HypF finger; Region: zf-HYPF; pfam07503 395962006663 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 395962006664 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 395962006665 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 395962006666 substrate binding site [chemical binding]; other site 395962006667 catalytic Zn binding site [ion binding]; other site 395962006668 NAD binding site [chemical binding]; other site 395962006669 structural Zn binding site [ion binding]; other site 395962006670 dimer interface [polypeptide binding]; other site 395962006671 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 395962006672 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 395962006673 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 395962006674 dimer interface [polypeptide binding]; other site 395962006675 putative functional site; other site 395962006676 putative MPT binding site; other site 395962006677 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 395962006678 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 395962006679 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962006680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 395962006681 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962006682 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 395962006683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962006684 Walker A motif; other site 395962006685 ATP binding site [chemical binding]; other site 395962006686 Walker B motif; other site 395962006687 arginine finger; other site 395962006688 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 395962006689 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 395962006690 TIGR01777 family protein; Region: yfcH 395962006691 putative NAD(P) binding site [chemical binding]; other site 395962006692 putative active site [active] 395962006693 Psb28 protein; Region: Psb28; cl04326 395962006694 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 395962006695 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 395962006696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962006697 active site 395962006698 S-layer homology domain; Region: SLH; pfam00395 395962006699 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 395962006700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962006701 Walker A motif; other site 395962006702 ATP binding site [chemical binding]; other site 395962006703 Walker B motif; other site 395962006704 arginine finger; other site 395962006705 Peptidase family M41; Region: Peptidase_M41; pfam01434 395962006706 lipoyl synthase; Provisional; Region: PRK12928 395962006707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962006708 FeS/SAM binding site; other site 395962006709 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395962006710 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 395962006711 active site 395962006712 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 395962006713 putative ADP-binding pocket [chemical binding]; other site 395962006714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006715 NAD(P) binding site [chemical binding]; other site 395962006716 active site 395962006717 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395962006718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006719 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962006720 active site 395962006721 Cupin domain; Region: Cupin_2; cl09118 395962006722 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962006723 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 395962006724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962006725 Walker A/P-loop; other site 395962006726 ATP binding site [chemical binding]; other site 395962006727 Q-loop/lid; other site 395962006728 ABC transporter signature motif; other site 395962006729 Walker B; other site 395962006730 D-loop; other site 395962006731 H-loop/switch region; other site 395962006732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962006733 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962006734 glycine dehydrogenase; Provisional; Region: PRK05367 395962006735 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 395962006736 tetramer interface [polypeptide binding]; other site 395962006737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962006738 catalytic residue [active] 395962006739 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 395962006740 tetramer interface [polypeptide binding]; other site 395962006741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962006742 catalytic residue [active] 395962006743 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962006744 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 395962006745 prolyl-tRNA synthetase; Provisional; Region: PRK09194 395962006746 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 395962006747 dimer interface [polypeptide binding]; other site 395962006748 motif 1; other site 395962006749 active site 395962006750 motif 2; other site 395962006751 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 395962006752 putative deacylase active site [active] 395962006753 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 395962006754 active site 395962006755 motif 3; other site 395962006756 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 395962006757 anticodon binding site; other site 395962006758 Late competence development protein ComFB; Region: ComFB; pfam10719 395962006759 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 395962006760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962006761 S-adenosylmethionine binding site [chemical binding]; other site 395962006762 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 395962006763 Cupin domain; Region: Cupin_2; cl09118 395962006764 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 395962006765 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 395962006766 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 395962006767 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 395962006768 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 395962006769 Qi binding site; other site 395962006770 intrachain domain interface; other site 395962006771 interchain domain interface [polypeptide binding]; other site 395962006772 heme bH binding site [chemical binding]; other site 395962006773 heme bL binding site [chemical binding]; other site 395962006774 Qo binding site; other site 395962006775 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 395962006776 interchain domain interface [polypeptide binding]; other site 395962006777 intrachain domain interface; other site 395962006778 Qi binding site; other site 395962006779 Qo binding site; other site 395962006780 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 395962006781 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962006782 Clp protease; Region: CLP_protease; pfam00574 395962006783 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 395962006784 oligomer interface [polypeptide binding]; other site 395962006785 active site residues [active] 395962006786 YcfA-like protein; Region: YcfA; cl00752 395962006787 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962006788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962006789 Probable transposase; Region: OrfB_IS605; pfam01385 395962006790 adenylosuccinate lyase; Provisional; Region: PRK07380 395962006791 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 395962006792 tetramer interface [polypeptide binding]; other site 395962006793 active site 395962006794 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 395962006795 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 395962006796 Domain of unknown function (DUF3523); Region: DUF3523; pfam12037 395962006797 H+ Antiporter protein; Region: 2A0121; TIGR00900 395962006798 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 395962006799 Recombination protein O N terminal; Region: RecO_N; cl15812 395962006800 Recombination protein O C terminal; Region: RecO_C; pfam02565 395962006801 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 395962006802 intersubunit interface [polypeptide binding]; other site 395962006803 active site 395962006804 catalytic residue [active] 395962006805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 395962006806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962006807 dimerization interface [polypeptide binding]; other site 395962006808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962006809 dimer interface [polypeptide binding]; other site 395962006810 phosphorylation site [posttranslational modification] 395962006811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962006812 ATP binding site [chemical binding]; other site 395962006813 Mg2+ binding site [ion binding]; other site 395962006814 G-X-G motif; other site 395962006815 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962006816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962006817 active site 395962006818 phosphorylation site [posttranslational modification] 395962006819 intermolecular recognition site; other site 395962006820 dimerization interface [polypeptide binding]; other site 395962006821 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962006822 DNA binding site [nucleotide binding] 395962006823 Response regulator receiver domain; Region: Response_reg; pfam00072 395962006824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962006825 active site 395962006826 phosphorylation site [posttranslational modification] 395962006827 intermolecular recognition site; other site 395962006828 dimerization interface [polypeptide binding]; other site 395962006829 NMT1-like family; Region: NMT1_2; cl15260 395962006830 NMT1/THI5 like; Region: NMT1; pfam09084 395962006831 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 395962006832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 395962006833 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 395962006834 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 395962006835 Walker A/P-loop; other site 395962006836 ATP binding site [chemical binding]; other site 395962006837 Q-loop/lid; other site 395962006838 ABC transporter signature motif; other site 395962006839 Walker B; other site 395962006840 D-loop; other site 395962006841 H-loop/switch region; other site 395962006842 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 395962006843 NMT1-like family; Region: NMT1_2; cl15260 395962006844 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 395962006845 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 395962006846 Walker A/P-loop; other site 395962006847 ATP binding site [chemical binding]; other site 395962006848 Q-loop/lid; other site 395962006849 ABC transporter signature motif; other site 395962006850 Walker B; other site 395962006851 D-loop; other site 395962006852 H-loop/switch region; other site 395962006853 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962006854 YcfA-like protein; Region: YcfA; cl00752 395962006855 acetyl-CoA synthetase; Provisional; Region: PRK00174 395962006856 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 395962006857 AMP-binding enzyme; Region: AMP-binding; cl15778 395962006858 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962006859 Cupin domain; Region: Cupin_2; cl09118 395962006860 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 395962006861 Protein of unknown function DUF262; Region: DUF262; cl14890 395962006862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962006863 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 395962006864 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 395962006865 metal ion-dependent adhesion site (MIDAS); other site 395962006866 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962006867 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 395962006868 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962006869 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 395962006870 Amidase; Region: Amidase; cl11426 395962006871 AAA domain; Region: AAA_13; pfam13166 395962006872 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 395962006873 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 395962006874 dimerization interface [polypeptide binding]; other site 395962006875 putative ATP binding site [chemical binding]; other site 395962006876 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 395962006877 Fatty acid desaturase; Region: FA_desaturase; pfam00487 395962006878 putative di-iron ligands [ion binding]; other site 395962006879 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 395962006880 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 395962006881 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395962006882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006883 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 395962006884 Helix-turn-helix domains; Region: HTH; cl00088 395962006885 Peptidase family M48; Region: Peptidase_M48; cl12018 395962006886 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 395962006887 catalytic triad [active] 395962006888 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 395962006889 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 395962006890 active site 395962006891 ribulose/triose binding site [chemical binding]; other site 395962006892 phosphate binding site [ion binding]; other site 395962006893 substrate (anthranilate) binding pocket [chemical binding]; other site 395962006894 product (indole) binding pocket [chemical binding]; other site 395962006895 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 395962006896 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 395962006897 homodimer interface [polypeptide binding]; other site 395962006898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962006899 catalytic residue [active] 395962006900 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 395962006901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962006903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395962006904 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 395962006905 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 395962006906 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 395962006907 trimer interface [polypeptide binding]; other site 395962006908 dimer interface [polypeptide binding]; other site 395962006909 putative active site [active] 395962006910 Protein of unknown function DUF262; Region: DUF262; cl14890 395962006911 Protein of unknown function DUF262; Region: DUF262; cl14890 395962006912 Protein of unknown function DUF262; Region: DUF262; cl14890 395962006913 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 395962006914 2TM domain; Region: 2TM; pfam13239 395962006915 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 395962006916 phosphate acetyltransferase; Reviewed; Region: PRK05632 395962006917 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962006918 DRTGG domain; Region: DRTGG; cl12147 395962006919 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 395962006920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962006921 S-adenosylmethionine binding site [chemical binding]; other site 395962006922 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395962006923 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962006924 active site 395962006925 ATP binding site [chemical binding]; other site 395962006926 substrate binding site [chemical binding]; other site 395962006927 activation loop (A-loop); other site 395962006928 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 395962006929 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 395962006930 putative ligand binding site [chemical binding]; other site 395962006931 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 395962006932 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 395962006933 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 395962006934 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 395962006935 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 395962006936 active site 395962006937 metal binding site [ion binding]; metal-binding site 395962006938 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 395962006939 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 395962006940 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 395962006941 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 395962006942 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 395962006943 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395962006944 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395962006945 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 395962006946 active site 395962006947 Ca binding site [ion binding]; other site 395962006948 catalytic site [active] 395962006949 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395962006950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962006951 dimer interface [polypeptide binding]; other site 395962006952 phosphorylation site [posttranslational modification] 395962006953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962006954 ATP binding site [chemical binding]; other site 395962006955 Mg2+ binding site [ion binding]; other site 395962006956 G-X-G motif; other site 395962006957 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962006958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962006959 active site 395962006960 phosphorylation site [posttranslational modification] 395962006961 intermolecular recognition site; other site 395962006962 dimerization interface [polypeptide binding]; other site 395962006963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962006964 DNA binding site [nucleotide binding] 395962006965 Creatinine amidohydrolase; Region: Creatininase; cl00618 395962006966 putative diguanylate cyclase; Provisional; Region: PRK09776 395962006967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962006968 putative active site [active] 395962006969 heme pocket [chemical binding]; other site 395962006970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962006971 putative active site [active] 395962006972 heme pocket [chemical binding]; other site 395962006973 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962006974 GAF domain; Region: GAF; cl15785 395962006975 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 395962006976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962006977 putative active site [active] 395962006978 heme pocket [chemical binding]; other site 395962006979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962006980 dimer interface [polypeptide binding]; other site 395962006981 phosphorylation site [posttranslational modification] 395962006982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962006983 ATP binding site [chemical binding]; other site 395962006984 Mg2+ binding site [ion binding]; other site 395962006985 G-X-G motif; other site 395962006986 Response regulator receiver domain; Region: Response_reg; pfam00072 395962006987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962006988 active site 395962006989 phosphorylation site [posttranslational modification] 395962006990 intermolecular recognition site; other site 395962006991 dimerization interface [polypeptide binding]; other site 395962006992 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 395962006993 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 395962006994 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962006995 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962006996 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 395962006997 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 395962006998 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 395962006999 cofactor binding site; other site 395962007000 DNA binding site [nucleotide binding] 395962007001 substrate interaction site [chemical binding]; other site 395962007002 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 395962007003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 395962007004 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 395962007005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007006 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 395962007007 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 395962007008 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 395962007009 NeuB family; Region: NeuB; cl00496 395962007010 SAF domain; Region: SAF; cl00555 395962007011 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 395962007012 Metal-binding active site; metal-binding site 395962007013 AP (apurinic/apyrimidinic) site pocket; other site 395962007014 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 395962007015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962007016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962007017 Glutaminase; Region: Glutaminase; cl00907 395962007018 Cache domain; Region: Cache_1; pfam02743 395962007019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962007020 dimerization interface [polypeptide binding]; other site 395962007021 PAS domain S-box; Region: sensory_box; TIGR00229 395962007022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962007023 putative active site [active] 395962007024 heme pocket [chemical binding]; other site 395962007025 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962007026 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962007027 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 395962007028 Surface antigen; Region: Bac_surface_Ag; cl03097 395962007029 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 395962007030 haemagglutination activity domain; Region: Haemagg_act; cl05436 395962007031 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 395962007032 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 395962007033 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 395962007034 dimerization interface [polypeptide binding]; other site 395962007035 active site 395962007036 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 395962007037 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 395962007038 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 395962007039 Cl- selectivity filter; other site 395962007040 Cl- binding residues [ion binding]; other site 395962007041 pore gating glutamate residue; other site 395962007042 dimer interface [polypeptide binding]; other site 395962007043 H+/Cl- coupling transport residue; other site 395962007044 FOG: CBS domain [General function prediction only]; Region: COG0517 395962007045 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 395962007046 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 395962007047 Ligand Binding Site [chemical binding]; other site 395962007048 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 395962007049 O-methyltransferase; Region: Methyltransf_3; pfam01596 395962007050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962007051 S-adenosylmethionine binding site [chemical binding]; other site 395962007052 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 395962007053 thiS-thiF/thiG interaction site; other site 395962007054 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 395962007055 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 395962007056 thiamine phosphate binding site [chemical binding]; other site 395962007057 active site 395962007058 pyrophosphate binding site [ion binding]; other site 395962007059 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 395962007060 putative hydrophobic ligand binding site [chemical binding]; other site 395962007061 carotene 7,8-desaturase; Region: zeta_caro_desat; TIGR02732 395962007062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007064 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 395962007065 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 395962007066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962007067 Coenzyme A binding pocket [chemical binding]; other site 395962007068 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 395962007069 dimer interface [polypeptide binding]; other site 395962007070 motif 1; other site 395962007071 active site 395962007072 motif 2; other site 395962007073 motif 3; other site 395962007074 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 395962007075 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 395962007076 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 395962007077 peptide chain release factor 2; Validated; Region: prfB; PRK00578 395962007078 RF-1 domain; Region: RF-1; cl02875 395962007079 RF-1 domain; Region: RF-1; cl02875 395962007080 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 395962007081 substrate binding site [chemical binding]; other site 395962007082 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962007083 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007084 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962007085 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007086 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007087 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007088 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007089 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007090 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007091 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 395962007092 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 395962007093 nucleotide binding pocket [chemical binding]; other site 395962007094 K-X-D-G motif; other site 395962007095 catalytic site [active] 395962007096 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 395962007097 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 395962007098 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 395962007099 Dimer interface [polypeptide binding]; other site 395962007100 Esterase/lipase [General function prediction only]; Region: COG1647 395962007101 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 395962007102 Chain length determinant protein; Region: Wzz; cl15801 395962007103 AAA domain; Region: AAA_31; pfam13614 395962007104 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962007105 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962007106 putative active site [active] 395962007107 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 395962007108 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 395962007109 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 395962007110 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 395962007111 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 395962007112 dimer interface [polypeptide binding]; other site 395962007113 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 395962007114 active site 395962007115 Fe binding site [ion binding]; other site 395962007116 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 395962007117 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 395962007118 Walker A/P-loop; other site 395962007119 ATP binding site [chemical binding]; other site 395962007120 Q-loop/lid; other site 395962007121 ABC transporter signature motif; other site 395962007122 Walker B; other site 395962007123 D-loop; other site 395962007124 H-loop/switch region; other site 395962007125 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 395962007126 CHAT domain; Region: CHAT; pfam12770 395962007127 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962007128 phosphopeptide binding site; other site 395962007129 Helix-turn-helix domains; Region: HTH; cl00088 395962007130 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 395962007131 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 395962007132 putative dimerization interface [polypeptide binding]; other site 395962007133 probable methyltransferase; Region: TIGR03438 395962007134 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 395962007135 UGMP family protein; Validated; Region: PRK09604 395962007136 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 395962007137 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 395962007138 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 395962007139 Divergent AAA domain; Region: AAA_4; pfam04326 395962007140 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 395962007141 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 395962007142 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 395962007143 5' RNA guide strand anchoring site; other site 395962007144 active site 395962007145 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 395962007146 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 395962007147 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962007148 putative active site [active] 395962007149 Rhomboid family; Region: Rhomboid; cl11446 395962007150 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 395962007151 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 395962007152 homodimer interface [polypeptide binding]; other site 395962007153 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 395962007154 active site pocket [active] 395962007155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007156 binding surface 395962007157 TPR motif; other site 395962007158 TPR repeat; Region: TPR_11; pfam13414 395962007159 putative glycosyl transferase; Provisional; Region: PRK10307 395962007160 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 395962007161 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 395962007162 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 395962007163 BolA-like protein; Region: BolA; cl00386 395962007164 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 395962007165 putative GSH binding site [chemical binding]; other site 395962007166 catalytic residues [active] 395962007167 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962007168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962007169 active site 395962007170 phosphorylation site [posttranslational modification] 395962007171 intermolecular recognition site; other site 395962007172 dimerization interface [polypeptide binding]; other site 395962007173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962007174 DNA binding site [nucleotide binding] 395962007175 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 395962007176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007177 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962007178 putative active site [active] 395962007179 ADP-glucose phosphorylase; Region: PLN02643 395962007180 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 395962007181 nucleotide binding site/active site [active] 395962007182 HIT family signature motif; other site 395962007183 catalytic residue [active] 395962007184 Domain of unknown function DUF20; Region: UPF0118; pfam01594 395962007185 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 395962007186 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 395962007187 Bacterial sugar transferase; Region: Bac_transf; cl00939 395962007188 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962007189 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007190 Predicted acetyltransferase [General function prediction only]; Region: COG3153 395962007191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962007192 Coenzyme A binding pocket [chemical binding]; other site 395962007193 Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639 395962007194 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 395962007195 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962007196 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 395962007197 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962007198 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 395962007199 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962007200 active site 395962007201 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395962007202 active site 395962007203 NTP binding site [chemical binding]; other site 395962007204 metal binding triad [ion binding]; metal-binding site 395962007205 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962007206 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 395962007207 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 395962007208 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 395962007209 Walker A/P-loop; other site 395962007210 ATP binding site [chemical binding]; other site 395962007211 Q-loop/lid; other site 395962007212 ABC transporter signature motif; other site 395962007213 Walker B; other site 395962007214 D-loop; other site 395962007215 H-loop/switch region; other site 395962007216 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 395962007217 putative carbohydrate binding site [chemical binding]; other site 395962007218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962007220 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 395962007221 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 395962007222 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962007223 ATP phosphoribosyltransferase; Region: HisG; cl15266 395962007224 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962007225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962007226 active site 395962007227 phosphorylation site [posttranslational modification] 395962007228 intermolecular recognition site; other site 395962007229 dimerization interface [polypeptide binding]; other site 395962007230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962007231 DNA binding site [nucleotide binding] 395962007232 septum formation inhibitor; Reviewed; Region: minC; PRK00513 395962007233 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 395962007234 septum site-determining protein MinD; Region: minD_bact; TIGR01968 395962007235 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 395962007236 Switch I; other site 395962007237 Switch II; other site 395962007238 Septum formation topological specificity factor MinE; Region: MinE; cl00538 395962007239 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 395962007240 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 395962007241 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 395962007242 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 395962007243 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395962007244 putative binding surface; other site 395962007245 active site 395962007246 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 395962007247 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 395962007248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962007249 ATP binding site [chemical binding]; other site 395962007250 Mg2+ binding site [ion binding]; other site 395962007251 G-X-G motif; other site 395962007252 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962007253 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395962007254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962007255 active site 395962007256 phosphorylation site [posttranslational modification] 395962007257 intermolecular recognition site; other site 395962007258 dimerization interface [polypeptide binding]; other site 395962007259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962007260 dimerization interface [polypeptide binding]; other site 395962007261 GAF domain; Region: GAF; cl15785 395962007262 GAF domain; Region: GAF_2; pfam13185 395962007263 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962007264 GAF domain; Region: GAF; cl15785 395962007265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 395962007266 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395962007267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395962007268 dimer interface [polypeptide binding]; other site 395962007269 putative CheW interface [polypeptide binding]; other site 395962007270 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 395962007271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 395962007272 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962007273 dimerization interface [polypeptide binding]; other site 395962007274 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962007275 GAF domain; Region: GAF; cl15785 395962007276 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962007277 GAF domain; Region: GAF; cl15785 395962007278 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 395962007279 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395962007280 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395962007281 dimer interface [polypeptide binding]; other site 395962007282 putative CheW interface [polypeptide binding]; other site 395962007283 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962007284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962007285 Response regulator receiver domain; Region: Response_reg; pfam00072 395962007286 active site 395962007287 phosphorylation site [posttranslational modification] 395962007288 intermolecular recognition site; other site 395962007289 dimerization interface [polypeptide binding]; other site 395962007290 Response regulator receiver domain; Region: Response_reg; pfam00072 395962007291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962007292 active site 395962007293 phosphorylation site [posttranslational modification] 395962007294 intermolecular recognition site; other site 395962007295 dimerization interface [polypeptide binding]; other site 395962007296 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 395962007297 substrate binding site; other site 395962007298 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 395962007299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007300 NAD(P) binding site [chemical binding]; other site 395962007301 active site 395962007302 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 395962007303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007304 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 395962007305 Cupin domain; Region: Cupin_2; cl09118 395962007306 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395962007307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007308 NAD(P) binding site [chemical binding]; other site 395962007309 active site 395962007310 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395962007311 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 395962007312 Ligand binding site; other site 395962007313 Putative Catalytic site; other site 395962007314 DXD motif; other site 395962007315 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395962007316 FAD binding domain; Region: FAD_binding_4; pfam01565 395962007317 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 395962007318 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 395962007319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007320 NAD(P) binding site [chemical binding]; other site 395962007321 active site 395962007322 S-layer homology domain; Region: SLH; pfam00395 395962007323 S-layer homology domain; Region: SLH; pfam00395 395962007324 NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]; Region: CobT; COG2038 395962007325 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 395962007326 active site pocket [active] 395962007327 putative dimer interface [polypeptide binding]; other site 395962007328 putative cataytic base [active] 395962007329 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962007330 putative active site [active] 395962007331 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 395962007332 dimerization interface [polypeptide binding]; other site 395962007333 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 395962007334 ATP binding site [chemical binding]; other site 395962007335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962007336 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 395962007337 dimer interface [polypeptide binding]; other site 395962007338 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 395962007339 ParB-like nuclease domain; Region: ParBc; cl02129 395962007340 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 395962007341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962007342 Response regulator receiver domain; Region: Response_reg; pfam00072 395962007343 active site 395962007344 phosphorylation site [posttranslational modification] 395962007345 intermolecular recognition site; other site 395962007346 dimerization interface [polypeptide binding]; other site 395962007347 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 395962007348 Helix-turn-helix domains; Region: HTH; cl00088 395962007349 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 395962007350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962007351 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962007352 Coenzyme A binding pocket [chemical binding]; other site 395962007353 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 395962007354 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962007355 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 395962007356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962007357 SOUL heme-binding protein; Region: SOUL; pfam04832 395962007358 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 395962007359 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 395962007360 substrate binding site [chemical binding]; other site 395962007361 EamA-like transporter family; Region: EamA; cl01037 395962007362 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 395962007363 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 395962007364 active site 395962007365 substrate binding site [chemical binding]; other site 395962007366 Mg2+ binding site [ion binding]; other site 395962007367 ribonuclease III; Reviewed; Region: rnc; PRK00102 395962007368 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 395962007369 dimerization interface [polypeptide binding]; other site 395962007370 active site 395962007371 metal binding site [ion binding]; metal-binding site 395962007372 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 395962007373 dsRNA binding site [nucleotide binding]; other site 395962007374 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962007375 GAF domain; Region: GAF; cl15785 395962007376 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395962007377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962007378 dimer interface [polypeptide binding]; other site 395962007379 phosphorylation site [posttranslational modification] 395962007380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962007381 ATP binding site [chemical binding]; other site 395962007382 Mg2+ binding site [ion binding]; other site 395962007383 G-X-G motif; other site 395962007384 Response regulator receiver domain; Region: Response_reg; pfam00072 395962007385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962007386 active site 395962007387 phosphorylation site [posttranslational modification] 395962007388 intermolecular recognition site; other site 395962007389 dimerization interface [polypeptide binding]; other site 395962007390 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 395962007391 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 395962007392 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 395962007393 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007394 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962007395 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007396 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007397 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962007398 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 395962007399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962007400 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962007401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962007402 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 395962007403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962007404 dimer interface [polypeptide binding]; other site 395962007405 conserved gate region; other site 395962007406 putative PBP binding loops; other site 395962007407 ABC-ATPase subunit interface; other site 395962007408 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 395962007409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962007410 dimer interface [polypeptide binding]; other site 395962007411 conserved gate region; other site 395962007412 putative PBP binding loops; other site 395962007413 ABC-ATPase subunit interface; other site 395962007414 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 395962007415 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 395962007416 Walker A/P-loop; other site 395962007417 ATP binding site [chemical binding]; other site 395962007418 Q-loop/lid; other site 395962007419 ABC transporter signature motif; other site 395962007420 Walker B; other site 395962007421 D-loop; other site 395962007422 H-loop/switch region; other site 395962007423 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 395962007424 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 395962007425 Walker A/P-loop; other site 395962007426 ATP binding site [chemical binding]; other site 395962007427 Q-loop/lid; other site 395962007428 ABC transporter signature motif; other site 395962007429 Walker B; other site 395962007430 D-loop; other site 395962007431 H-loop/switch region; other site 395962007432 phosphoglucomutase; Region: PLN02307 395962007433 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 395962007434 substrate binding site [chemical binding]; other site 395962007435 dimer interface [polypeptide binding]; other site 395962007436 active site 395962007437 metal binding site [ion binding]; metal-binding site 395962007438 Protein kinase domain; Region: Pkinase; pfam00069 395962007439 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962007440 active site 395962007441 ATP binding site [chemical binding]; other site 395962007442 substrate binding site [chemical binding]; other site 395962007443 activation loop (A-loop); other site 395962007444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007445 TPR motif; other site 395962007446 TPR repeat; Region: TPR_11; pfam13414 395962007447 binding surface 395962007448 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 395962007449 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 395962007450 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962007451 FeS/SAM binding site; other site 395962007452 TRAM domain; Region: TRAM; cl01282 395962007453 Nuclease-related domain; Region: NERD; pfam08378 395962007454 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395962007455 active site 395962007456 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 395962007457 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 395962007458 proposed catalytic triad [active] 395962007459 active site nucleophile [active] 395962007460 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 395962007461 OstA-like protein; Region: OstA; cl00844 395962007462 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 395962007463 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 395962007464 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 395962007465 PPIC-type PPIASE domain; Region: Rotamase; cl08278 395962007466 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 395962007467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962007468 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395962007469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007470 binding surface 395962007471 TPR motif; other site 395962007472 TPR repeat; Region: TPR_11; pfam13414 395962007473 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962007474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007475 binding surface 395962007476 TPR motif; other site 395962007477 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 395962007478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962007479 TPR motif; other site 395962007480 binding surface 395962007481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007482 binding surface 395962007483 TPR motif; other site 395962007484 TPR repeat; Region: TPR_11; pfam13414 395962007485 TPR repeat; Region: TPR_11; pfam13414 395962007486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007487 binding surface 395962007488 TPR motif; other site 395962007489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 395962007490 active site 395962007491 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 395962007492 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962007493 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962007494 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395962007495 ligand binding site [chemical binding]; other site 395962007496 flexible hinge region; other site 395962007497 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 395962007498 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 395962007499 putative active site [active] 395962007500 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 395962007501 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 395962007502 Walker A/P-loop; other site 395962007503 ATP binding site [chemical binding]; other site 395962007504 Q-loop/lid; other site 395962007505 ABC transporter signature motif; other site 395962007506 Walker B; other site 395962007507 D-loop; other site 395962007508 H-loop/switch region; other site 395962007509 GAF domain; Region: GAF_2; pfam13185 395962007510 GAF domain; Region: GAF; cl15785 395962007511 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962007512 metal binding site [ion binding]; metal-binding site 395962007513 active site 395962007514 I-site; other site 395962007515 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 395962007516 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 395962007517 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 395962007518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962007519 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962007520 putative active site [active] 395962007521 phosphoenolpyruvate synthase; Validated; Region: PRK06464 395962007522 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 395962007523 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 395962007524 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 395962007525 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962007526 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962007527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962007528 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962007529 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395962007530 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962007531 active site 395962007532 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 395962007533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007534 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 395962007535 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962007536 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; cl14104 395962007537 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395962007538 HSP70 interaction site [polypeptide binding]; other site 395962007539 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 395962007540 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 395962007541 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 395962007542 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 395962007543 dimer interface [polypeptide binding]; other site 395962007544 active site 395962007545 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962007546 Protein of unknown function (DUF433); Region: DUF433; cl01030 395962007547 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 395962007548 YcfA-like protein; Region: YcfA; cl00752 395962007549 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962007550 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 395962007551 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 395962007552 HIGH motif; other site 395962007553 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 395962007554 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395962007555 active site 395962007556 KMSKS motif; other site 395962007557 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 395962007558 tRNA binding surface [nucleotide binding]; other site 395962007559 Transposase; Region: HTH_Tnp_IS630; pfam01710 395962007560 Integrase core domain; Region: rve; cl01316 395962007561 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 395962007562 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 395962007563 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962007564 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 395962007565 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 395962007566 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 395962007567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007568 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 395962007569 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962007570 V-type ATP synthase subunit B; Provisional; Region: PRK02118 395962007571 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 395962007572 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 395962007573 Walker A motif homologous position; other site 395962007574 Walker B motif; other site 395962007575 ATP synthase subunit D; Region: ATP-synt_D; cl00613 395962007576 V-type ATP synthase subunit I; Validated; Region: PRK05771 395962007577 ATP synthase subunit C; Region: ATP-synt_C; cl00466 395962007578 Plant ATP synthase F0; Region: YMF19; cl07975 395962007579 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 395962007580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962007581 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962007582 Probable transposase; Region: OrfB_IS605; pfam01385 395962007583 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962007584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 395962007585 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962007586 V-type ATP synthase subunit A; Provisional; Region: PRK04192 395962007587 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 395962007588 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 395962007589 Walker A motif/ATP binding site; other site 395962007590 Walker B motif; other site 395962007591 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 395962007592 protein I interface; other site 395962007593 D2 interface; other site 395962007594 protein T interface; other site 395962007595 chlorophyll binding site; other site 395962007596 beta carotene binding site; other site 395962007597 pheophytin binding site; other site 395962007598 manganese-stabilizing polypeptide interface; other site 395962007599 CP43 interface; other site 395962007600 protein L interface; other site 395962007601 oxygen evolving complex binding site; other site 395962007602 bromide binding site; other site 395962007603 quinone binding site; other site 395962007604 Fe binding site [ion binding]; other site 395962007605 core light harvesting interface; other site 395962007606 cytochrome b559 alpha subunit interface; other site 395962007607 cytochrome c-550 interface; other site 395962007608 protein J interface; other site 395962007609 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 395962007610 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 395962007611 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 395962007612 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 395962007613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962007614 Probable transposase; Region: OrfB_IS605; pfam01385 395962007615 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962007616 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 395962007617 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 395962007618 active site 395962007619 Substrate binding site; other site 395962007620 Mg++ binding site; other site 395962007621 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 395962007622 putative trimer interface [polypeptide binding]; other site 395962007623 putative CoA binding site [chemical binding]; other site 395962007624 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 395962007625 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 395962007626 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 395962007627 dimer interface [polypeptide binding]; other site 395962007628 ssDNA binding site [nucleotide binding]; other site 395962007629 tetramer (dimer of dimers) interface [polypeptide binding]; other site 395962007630 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 395962007631 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 395962007632 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 395962007633 putative ligand binding site [chemical binding]; other site 395962007634 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962007635 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962007636 fumarate hydratase; Reviewed; Region: fumC; PRK00485 395962007637 Class II fumarases; Region: Fumarase_classII; cd01362 395962007638 active site 395962007639 tetramer interface [polypeptide binding]; other site 395962007640 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 395962007641 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962007642 Walker A/P-loop; other site 395962007643 ATP binding site [chemical binding]; other site 395962007644 Protein of unknown function (DUF552); Region: DUF552; cl00775 395962007645 Photosystem II Pbs27; Region: PSII_Pbs27; cl11841 395962007646 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 395962007647 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 395962007648 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962007649 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 395962007650 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962007651 chaperone protein DnaJ; Provisional; Region: PRK14293 395962007652 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395962007653 HSP70 interaction site [polypeptide binding]; other site 395962007654 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 395962007655 Zn binding sites [ion binding]; other site 395962007656 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 395962007657 dimer interface [polypeptide binding]; other site 395962007658 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 395962007659 CPxP motif; other site 395962007660 GTPase RsgA; Reviewed; Region: PRK12289 395962007661 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 395962007662 RNA binding site [nucleotide binding]; other site 395962007663 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 395962007664 GTPase/Zn-binding domain interface [polypeptide binding]; other site 395962007665 GTP/Mg2+ binding site [chemical binding]; other site 395962007666 G4 box; other site 395962007667 G5 box; other site 395962007668 G1 box; other site 395962007669 Switch I region; other site 395962007670 G2 box; other site 395962007671 G3 box; other site 395962007672 Switch II region; other site 395962007673 seryl-tRNA synthetase; Provisional; Region: PRK05431 395962007674 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 395962007675 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 395962007676 dimer interface [polypeptide binding]; other site 395962007677 active site 395962007678 motif 1; other site 395962007679 motif 2; other site 395962007680 motif 3; other site 395962007681 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 395962007682 putative catalytic site [active] 395962007683 putative metal binding site [ion binding]; other site 395962007684 putative phosphate binding site [ion binding]; other site 395962007685 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 395962007686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007687 TIGR03442 family protein; Region: TIGR03442 395962007688 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 395962007689 putative active site [active] 395962007690 putative dimer interface [polypeptide binding]; other site 395962007691 TIGR03440 family protein; Region: unchr_TIGR03440 395962007692 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 395962007693 putative transposase; Provisional; Region: PHA02942 395962007694 Probable transposase; Region: OrfB_IS605; pfam01385 395962007695 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 395962007696 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962007697 phage shock protein A; Region: phageshock_pspA; TIGR02977 395962007698 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 395962007699 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 395962007700 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 395962007701 Walker A/P-loop; other site 395962007702 ATP binding site [chemical binding]; other site 395962007703 Q-loop/lid; other site 395962007704 ABC transporter signature motif; other site 395962007705 Walker B; other site 395962007706 D-loop; other site 395962007707 H-loop/switch region; other site 395962007708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962007709 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962007710 Probable transposase; Region: OrfB_IS605; pfam01385 395962007711 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962007712 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 395962007713 homotrimer interaction site [polypeptide binding]; other site 395962007714 zinc binding site [ion binding]; other site 395962007715 CDP-binding sites; other site 395962007716 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 395962007717 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 395962007718 putative dimer interface [polypeptide binding]; other site 395962007719 putative anticodon binding site; other site 395962007720 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 395962007721 homodimer interface [polypeptide binding]; other site 395962007722 motif 1; other site 395962007723 motif 2; other site 395962007724 active site 395962007725 motif 3; other site 395962007726 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 395962007727 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 395962007728 DXD motif; other site 395962007729 PilZ domain; Region: PilZ; cl01260 395962007730 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 395962007731 catalytic center binding site [active] 395962007732 ATP binding site [chemical binding]; other site 395962007733 pteridine reductase; Provisional; Region: PRK09135 395962007734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007735 NAD(P) binding site [chemical binding]; other site 395962007736 active site 395962007737 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 395962007738 active site 395962007739 zinc binding site [ion binding]; other site 395962007740 TPR repeat; Region: TPR_11; pfam13414 395962007741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007742 binding surface 395962007743 TPR motif; other site 395962007744 TPR repeat; Region: TPR_11; pfam13414 395962007745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007746 binding surface 395962007747 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395962007748 TPR motif; other site 395962007749 AIR carboxylase; Region: AIRC; cl00310 395962007750 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962007751 H-loop/switch region; other site 395962007752 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 395962007753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007754 TPR motif; other site 395962007755 TPR repeat; Region: TPR_11; pfam13414 395962007756 binding surface 395962007757 TPR repeat; Region: TPR_11; pfam13414 395962007758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007759 binding surface 395962007760 TPR motif; other site 395962007761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962007762 TPR repeat; Region: TPR_11; pfam13414 395962007763 binding surface 395962007764 TPR motif; other site 395962007765 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 395962007766 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 395962007767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007768 GUN4-like; Region: GUN4; pfam05419 395962007769 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395962007770 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 395962007771 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962007772 Low molecular weight phosphatase family; Region: LMWPc; cd00115 395962007773 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 395962007774 active site 395962007775 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 395962007776 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474 395962007777 Predicted RNA interaction site [nucleotide binding]; other site 395962007778 putative binding site; other site 395962007779 Mutations affecting start-site selection; other site 395962007780 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 395962007781 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 395962007782 putative ligand binding site [chemical binding]; other site 395962007783 Helix-turn-helix domains; Region: HTH; cl00088 395962007784 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 395962007785 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 395962007786 Domain interface; other site 395962007787 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 395962007788 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 395962007789 Major royal jelly protein; Region: MRJP; pfam03022 395962007790 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 395962007791 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 395962007792 potential catalytic triad [active] 395962007793 conserved cys residue [active] 395962007794 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 395962007795 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 395962007796 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 395962007797 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 395962007798 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 395962007799 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 395962007800 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 395962007801 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 395962007802 Ferritin-like; Region: Ferritin-like; pfam12902 395962007803 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962007804 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007805 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007806 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 395962007807 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 395962007808 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395962007809 active site 395962007810 catalytic tetrad [active] 395962007811 GUN4-like; Region: GUN4; pfam05419 395962007812 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962007813 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007814 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962007815 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007816 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007817 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962007818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395962007819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395962007820 putative substrate translocation pore; other site 395962007821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 395962007822 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962007823 dimerization interface [polypeptide binding]; other site 395962007824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395962007825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962007826 dimer interface [polypeptide binding]; other site 395962007827 phosphorylation site [posttranslational modification] 395962007828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962007829 ATP binding site [chemical binding]; other site 395962007830 Mg2+ binding site [ion binding]; other site 395962007831 G-X-G motif; other site 395962007832 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 395962007833 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962007834 DRTGG domain; Region: DRTGG; cl12147 395962007835 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 395962007836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395962007837 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395962007838 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 395962007839 Type III pantothenate kinase; Region: Pan_kinase; cl09130 395962007840 Dehydratase family; Region: ILVD_EDD; cl00340 395962007841 L-asparaginase II; Region: Asparaginase_II; cl01842 395962007842 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 395962007843 Oligomerisation domain; Region: Oligomerisation; cl00519 395962007844 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 395962007845 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 395962007846 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395962007847 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 395962007848 Walker A/P-loop; other site 395962007849 ATP binding site [chemical binding]; other site 395962007850 Q-loop/lid; other site 395962007851 ABC transporter signature motif; other site 395962007852 Walker B; other site 395962007853 D-loop; other site 395962007854 H-loop/switch region; other site 395962007855 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 395962007856 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962007857 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 395962007858 nucleotide binding site/active site [active] 395962007859 HIT family signature motif; other site 395962007860 catalytic residue [active] 395962007861 exonuclease SbcC; Region: sbcc; TIGR00618 395962007862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962007863 Walker A/P-loop; other site 395962007864 ATP binding site [chemical binding]; other site 395962007865 Q-loop/lid; other site 395962007866 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962007867 ABC transporter signature motif; other site 395962007868 Walker B; other site 395962007869 D-loop; other site 395962007870 H-loop/switch region; other site 395962007871 DNA polymerase I; Provisional; Region: PRK05755 395962007872 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 395962007873 active site 395962007874 metal binding site 1 [ion binding]; metal-binding site 395962007875 putative 5' ssDNA interaction site; other site 395962007876 metal binding site 3; metal-binding site 395962007877 metal binding site 2 [ion binding]; metal-binding site 395962007878 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 395962007879 putative DNA binding site [nucleotide binding]; other site 395962007880 putative metal binding site [ion binding]; other site 395962007881 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 395962007882 active site 395962007883 catalytic site [active] 395962007884 substrate binding site [chemical binding]; other site 395962007885 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 395962007886 active site 395962007887 DNA binding site [nucleotide binding] 395962007888 catalytic site [active] 395962007889 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 395962007890 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395962007891 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 395962007892 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 395962007893 Cytochrome P450; Region: p450; pfam00067 395962007894 Lipoxygenase; Region: Lipoxygenase; pfam00305 395962007895 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 395962007896 Cation efflux family; Region: Cation_efflux; cl00316 395962007897 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 395962007898 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 395962007899 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 395962007900 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 395962007901 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 395962007902 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 395962007903 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 395962007904 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 395962007905 trimer interface [polypeptide binding]; other site 395962007906 putative metal binding site [ion binding]; other site 395962007907 Protein of unknown function (DUF2396); Region: DUF2396; cl09868 395962007908 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395962007909 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 395962007910 active site 395962007911 metal binding site [ion binding]; metal-binding site 395962007912 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 395962007913 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 395962007914 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 395962007915 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 395962007916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962007917 Coenzyme A binding pocket [chemical binding]; other site 395962007918 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395962007919 GTP-binding protein YchF; Reviewed; Region: PRK09601 395962007920 YchF GTPase; Region: YchF; cd01900 395962007921 G1 box; other site 395962007922 GTP/Mg2+ binding site [chemical binding]; other site 395962007923 Switch I region; other site 395962007924 G2 box; other site 395962007925 Switch II region; other site 395962007926 G3 box; other site 395962007927 G4 box; other site 395962007928 G5 box; other site 395962007929 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 395962007930 BtpA family; Region: BtpA; cl00440 395962007931 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 395962007932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962007933 HEAT repeats; Region: HEAT_2; pfam13646 395962007934 Protein of unknown function (DUF497); Region: DUF497; cl01108 395962007935 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 395962007936 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 395962007937 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 395962007938 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 395962007939 active site 395962007940 catalytic site [active] 395962007941 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 395962007942 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 395962007943 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395962007944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962007945 FO synthase subunit 2; Reviewed; Region: PRK07360 395962007946 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 395962007947 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 395962007948 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 395962007949 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 395962007950 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 395962007951 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 395962007952 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 395962007953 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 395962007954 Phycobilisome protein; Region: Phycobilisome; cl08227 395962007955 Phycobilisome protein; Region: Phycobilisome; cl08227 395962007956 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 395962007957 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 395962007958 RNA binding site [nucleotide binding]; other site 395962007959 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 395962007960 RNA binding site [nucleotide binding]; other site 395962007961 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 395962007962 RNA binding site [nucleotide binding]; other site 395962007963 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 395962007964 ATP cone domain; Region: ATP-cone; pfam03477 395962007965 Photosystem II reaction centre T protein; Region: PsbT; cl11601 395962007966 Photosystem II protein; Region: PSII; cl08223 395962007967 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 395962007968 Bacterial SH3 domain; Region: SH3_3; cl02551 395962007969 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 395962007970 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 395962007971 active site 395962007972 metal binding site [ion binding]; metal-binding site 395962007973 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395962007974 XisH protein; Region: XisH; pfam08814 395962007975 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 395962007976 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395962007977 P-loop; other site 395962007978 Magnesium ion binding site [ion binding]; other site 395962007979 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 395962007980 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 395962007981 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 395962007982 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962007983 putative acyl-acceptor binding pocket; other site 395962007984 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 395962007985 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 395962007986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395962007987 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 395962007988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395962007989 DNA binding residues [nucleotide binding] 395962007990 Protein of unknown function (DUF760); Region: DUF760; pfam05542 395962007991 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 395962007992 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395962007993 minor groove reading motif; other site 395962007994 helix-hairpin-helix signature motif; other site 395962007995 substrate binding pocket [chemical binding]; other site 395962007996 active site 395962007997 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 395962007998 active site 395962007999 8-oxo-dGMP binding site [chemical binding]; other site 395962008000 nudix motif; other site 395962008001 metal binding site [ion binding]; metal-binding site 395962008002 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 395962008003 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905 395962008004 putative active site [active] 395962008005 Zn binding site [ion binding]; other site 395962008006 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 395962008007 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 395962008008 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 395962008009 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 395962008010 GAF domain; Region: GAF; cl15785 395962008011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962008012 phosphorylation site [posttranslational modification] 395962008013 dimer interface [polypeptide binding]; other site 395962008014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962008015 ATP binding site [chemical binding]; other site 395962008016 Mg2+ binding site [ion binding]; other site 395962008017 G-X-G motif; other site 395962008018 glyoxylate reductase; Reviewed; Region: PRK13243 395962008019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008020 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 395962008021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008022 NAD(P) binding site [chemical binding]; other site 395962008023 active site 395962008024 CAAX protease self-immunity; Region: Abi; cl00558 395962008025 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 395962008026 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 395962008027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008028 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 395962008029 Ubiquitin-like proteins; Region: UBQ; cl00155 395962008030 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 395962008031 Protein of unknown function DUF82; Region: DUF82; pfam01927 395962008032 AMIN domain; Region: AMIN; pfam11741 395962008033 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 395962008034 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 395962008035 N-terminal plug; other site 395962008036 ligand-binding site [chemical binding]; other site 395962008037 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 395962008038 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 395962008039 siderophore binding site; other site 395962008040 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 395962008041 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 395962008042 Walker A/P-loop; other site 395962008043 ATP binding site [chemical binding]; other site 395962008044 Q-loop/lid; other site 395962008045 ABC transporter signature motif; other site 395962008046 Walker B; other site 395962008047 D-loop; other site 395962008048 H-loop/switch region; other site 395962008049 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 395962008050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 395962008051 ABC-ATPase subunit interface; other site 395962008052 dimer interface [polypeptide binding]; other site 395962008053 putative PBP binding regions; other site 395962008054 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 395962008055 ABC-ATPase subunit interface; other site 395962008056 dimer interface [polypeptide binding]; other site 395962008057 putative PBP binding regions; other site 395962008058 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 395962008059 MORN repeat; Region: MORN; cl14787 395962008060 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 395962008061 MORN repeat; Region: MORN; cl14787 395962008062 MORN repeat; Region: MORN; cl14787 395962008063 MORN repeat; Region: MORN; cl14787 395962008064 Gram-negative bacterial tonB protein; Region: TonB; cl10048 395962008065 NAD synthetase; Provisional; Region: PRK13981 395962008066 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 395962008067 multimer interface [polypeptide binding]; other site 395962008068 active site 395962008069 catalytic triad [active] 395962008070 protein interface 1 [polypeptide binding]; other site 395962008071 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 395962008072 homodimer interface [polypeptide binding]; other site 395962008073 NAD binding pocket [chemical binding]; other site 395962008074 ATP binding pocket [chemical binding]; other site 395962008075 Mg binding site [ion binding]; other site 395962008076 active-site loop [active] 395962008077 Condensation domain; Region: Condensation; pfam00668 395962008078 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395962008079 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008080 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008081 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008083 peptide synthase; Provisional; Region: PRK12316 395962008084 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008085 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008086 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962008087 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962008088 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 395962008089 peptide synthase; Provisional; Region: PRK12316 395962008090 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008091 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008092 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008093 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 395962008094 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 395962008095 peptide synthase; Provisional; Region: PRK12467 395962008096 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008097 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008098 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962008099 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008100 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008101 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008102 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 395962008103 peptide synthase; Provisional; Region: PRK12467 395962008104 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962008105 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008106 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008107 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008108 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 395962008109 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395962008110 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 395962008111 active site 395962008112 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395962008113 Acyl transferase domain; Region: Acyl_transf_1; cl08282 395962008114 peptide synthase; Validated; Region: PRK05691 395962008115 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008116 Condensation domain; Region: Condensation; pfam00668 395962008117 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395962008118 Nonribosomal peptide synthase; Region: NRPS; pfam08415 395962008119 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008120 AMP-binding enzyme; Region: AMP-binding; cl15778 395962008121 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008122 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395962008123 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 395962008124 active site 395962008125 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395962008126 Acyl transferase domain; Region: Acyl_transf_1; cl08282 395962008127 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 395962008128 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008129 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 395962008130 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395962008131 active site 395962008132 Acyl transferase domain; Region: Acyl_transf_1; cl08282 395962008133 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 395962008134 putative NADP binding site [chemical binding]; other site 395962008135 active site 395962008136 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008137 potential frameshift: common BLAST hit: gi|218247790|ref|YP_002373161.1| Erythronolide synthase 395962008138 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395962008139 active site 395962008140 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395962008141 Acyl transferase domain; Region: Acyl_transf_1; cl08282 395962008142 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008143 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395962008144 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962008145 H+ Antiporter protein; Region: 2A0121; TIGR00900 395962008146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395962008147 putative substrate translocation pore; other site 395962008148 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 395962008149 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 395962008150 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 395962008151 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 395962008152 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 395962008153 ornithine carbamoyltransferase; Provisional; Region: PRK00779 395962008154 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 395962008155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008156 Uncharacterized conserved protein [Function unknown]; Region: COG4997 395962008157 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395962008158 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395962008159 active site 395962008160 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 395962008161 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 395962008162 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 395962008163 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 395962008164 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 395962008165 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 395962008166 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395962008167 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 395962008168 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 395962008169 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 395962008170 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 395962008171 DctM-like transporters; Region: DctM; pfam06808 395962008172 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 395962008173 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 395962008174 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 395962008175 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 395962008176 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 395962008177 substrate binding site [chemical binding]; other site 395962008178 active site 395962008179 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 395962008180 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 395962008181 DNA binding residues [nucleotide binding] 395962008182 putative dimer interface [polypeptide binding]; other site 395962008183 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395962008184 oligomeric interface; other site 395962008185 putative active site [active] 395962008186 homodimer interface [polypeptide binding]; other site 395962008187 Restriction endonuclease; Region: Mrr_cat; cl00516 395962008188 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 395962008189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962008190 AAA domain; Region: AAA_22; pfam13401 395962008191 Helix-turn-helix domains; Region: HTH; cl00088 395962008192 Winged helix-turn helix; Region: HTH_29; pfam13551 395962008193 Integrase core domain; Region: rve; cl01316 395962008194 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 395962008195 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 395962008196 putative active site [active] 395962008197 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 395962008198 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395962008199 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395962008200 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 395962008201 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395962008202 active site 395962008203 NTP binding site [chemical binding]; other site 395962008204 metal binding triad [ion binding]; metal-binding site 395962008205 antibiotic binding site [chemical binding]; other site 395962008206 Protein of unknown function DUF86; Region: DUF86; cl01031 395962008207 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 395962008208 Fic/DOC family; Region: Fic; cl00960 395962008209 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 395962008210 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395962008211 active site 395962008212 NTP binding site [chemical binding]; other site 395962008213 metal binding triad [ion binding]; metal-binding site 395962008214 antibiotic binding site [chemical binding]; other site 395962008215 Protein of unknown function DUF86; Region: DUF86; cl01031 395962008216 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 395962008217 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 395962008218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962008219 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962008220 ATP binding site [chemical binding]; other site 395962008221 putative Mg++ binding site [ion binding]; other site 395962008222 Protein of unknown function DUF45; Region: DUF45; cl00636 395962008223 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 395962008224 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 395962008225 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 395962008226 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 395962008227 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 395962008228 hinge; other site 395962008229 active site 395962008230 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 395962008231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962008232 binding surface 395962008233 TPR motif; other site 395962008234 TPR repeat; Region: TPR_11; pfam13414 395962008235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962008236 binding surface 395962008237 TPR repeat; Region: TPR_11; pfam13414 395962008238 TPR motif; other site 395962008239 Acylphosphatase; Region: Acylphosphatase; cl00551 395962008240 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962008241 putative active site [active] 395962008242 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 395962008243 Cysteine-rich domain; Region: CCG; pfam02754 395962008244 Cysteine-rich domain; Region: CCG; pfam02754 395962008245 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962008246 YcfA-like protein; Region: YcfA; cl00752 395962008247 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962008248 lipoyl synthase; Provisional; Region: PRK05481 395962008249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962008250 FeS/SAM binding site; other site 395962008251 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962008252 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008253 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008254 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 395962008255 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 395962008256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008257 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 395962008258 IHF dimer interface [polypeptide binding]; other site 395962008259 IHF - DNA interface [nucleotide binding]; other site 395962008260 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 395962008261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395962008262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962008263 homodimer interface [polypeptide binding]; other site 395962008264 catalytic residue [active] 395962008265 Family description; Region: VCBS; pfam13517 395962008266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962008268 S-adenosylmethionine binding site [chemical binding]; other site 395962008269 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395962008270 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962008271 active site 395962008272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962008273 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962008274 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 395962008275 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 395962008276 Vitamin K epoxide reductase family; Region: VKOR; cl01729 395962008277 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962008278 putative active site [active] 395962008279 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 395962008280 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962008281 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 395962008282 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 395962008283 dihydrodipicolinate synthase; Region: dapA; TIGR00674 395962008284 dimer interface [polypeptide binding]; other site 395962008285 active site 395962008286 catalytic residue [active] 395962008287 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 395962008288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008289 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 395962008290 trigger factor; Provisional; Region: tig; PRK01490 395962008291 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 395962008292 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 395962008293 Clp protease; Region: CLP_protease; pfam00574 395962008294 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 395962008295 oligomer interface [polypeptide binding]; other site 395962008296 active site residues [active] 395962008297 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 395962008298 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 395962008299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962008300 Walker A motif; other site 395962008301 ATP binding site [chemical binding]; other site 395962008302 Walker B motif; other site 395962008303 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 395962008304 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962008305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395962008306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 395962008307 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 395962008308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 395962008309 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 395962008310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 395962008311 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 395962008312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962008313 S-adenosylmethionine binding site [chemical binding]; other site 395962008314 Tic22-like family; Region: Tic22; cl04468 395962008315 Tic22-like family; Region: Tic22; cl04468 395962008316 Mg chelatase-related protein; Region: TIGR00368 395962008317 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 395962008318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962008319 Walker A motif; other site 395962008320 ATP binding site [chemical binding]; other site 395962008321 Walker B motif; other site 395962008322 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 395962008323 Chorismate mutase type II; Region: CM_2; cl00693 395962008324 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 395962008325 active site 395962008326 Ion channel; Region: Ion_trans_2; cl11596 395962008327 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 395962008328 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 395962008329 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 395962008330 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 395962008331 MPN+ (JAMM) motif; other site 395962008332 Zinc-binding site [ion binding]; other site 395962008333 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 395962008334 HicB family; Region: HicB; pfam05534 395962008335 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 395962008336 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 395962008337 hypothetical protein; Validated; Region: PRK07411 395962008338 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 395962008339 ATP binding site [chemical binding]; other site 395962008340 substrate interface [chemical binding]; other site 395962008341 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 395962008342 active site residue [active] 395962008343 YacP-like NYN domain; Region: NYN_YacP; cl01491 395962008344 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 395962008345 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 395962008346 Walker A/P-loop; other site 395962008347 ATP binding site [chemical binding]; other site 395962008348 Q-loop/lid; other site 395962008349 ABC transporter signature motif; other site 395962008350 Walker B; other site 395962008351 D-loop; other site 395962008352 H-loop/switch region; other site 395962008353 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 395962008354 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 395962008355 active site 395962008356 HIGH motif; other site 395962008357 dimer interface [polypeptide binding]; other site 395962008358 KMSKS motif; other site 395962008359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 395962008360 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 395962008361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008362 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 395962008363 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 395962008364 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395962008365 active site 395962008366 catalytic tetrad [active] 395962008367 Protein of unknown function (DUF433); Region: DUF433; cl01030 395962008368 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 395962008369 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 395962008370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008371 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 395962008372 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 395962008373 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 395962008374 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 395962008375 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 395962008376 Malic enzyme, N-terminal domain; Region: malic; pfam00390 395962008377 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 395962008378 putative NAD(P) binding site [chemical binding]; other site 395962008379 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 395962008380 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 395962008381 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 395962008382 Response regulator receiver domain; Region: Response_reg; pfam00072 395962008383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962008384 active site 395962008385 phosphorylation site [posttranslational modification] 395962008386 intermolecular recognition site; other site 395962008387 dimerization interface [polypeptide binding]; other site 395962008388 MAPEG family; Region: MAPEG; cl09190 395962008389 phosphoglycolate phosphatase; Provisional; Region: PRK13225 395962008390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962008391 motif II; other site 395962008392 iron-sulfur cluster binding protein, putative; Region: TIGR00276 395962008393 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 395962008394 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 395962008395 Protein export membrane protein; Region: SecD_SecF; cl14618 395962008396 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 395962008397 Protein export membrane protein; Region: SecD_SecF; cl14618 395962008398 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 395962008399 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 395962008400 alpha subunit interface [polypeptide binding]; other site 395962008401 TPP binding site [chemical binding]; other site 395962008402 heterodimer interface [polypeptide binding]; other site 395962008403 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395962008404 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 395962008405 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962008406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962008407 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962008408 putative active site [active] 395962008409 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 395962008410 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 395962008411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962008412 active site 395962008413 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 395962008414 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 395962008415 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395962008416 protein binding site [polypeptide binding]; other site 395962008417 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 395962008418 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 395962008419 30S subunit binding site; other site 395962008420 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962008421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962008422 Probable transposase; Region: OrfB_IS605; pfam01385 395962008423 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962008424 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 395962008425 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 395962008426 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 395962008427 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 395962008428 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 395962008429 dimerization interface [polypeptide binding]; other site 395962008430 domain crossover interface; other site 395962008431 redox-dependent activation switch; other site 395962008432 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 395962008433 PLD-like domain; Region: PLDc_2; pfam13091 395962008434 putative active site [active] 395962008435 catalytic site [active] 395962008436 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 395962008437 PLD-like domain; Region: PLDc_2; pfam13091 395962008438 putative active site [active] 395962008439 catalytic site [active] 395962008440 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 395962008441 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 395962008442 Cobalt transport protein; Region: CbiQ; cl00463 395962008443 anthranilate synthase component I-like protein; Validated; Region: PRK05940 395962008444 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 395962008445 chorismate binding enzyme; Region: Chorismate_bind; cl10555 395962008446 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395962008447 Bacitracin resistance protein BacA; Region: BacA; cl00858 395962008448 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 395962008449 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395962008450 inhibitor-cofactor binding pocket; inhibition site 395962008451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962008452 catalytic residue [active] 395962008453 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 395962008454 Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459 395962008455 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395962008456 catalytic loop [active] 395962008457 iron binding site [ion binding]; other site 395962008458 intracellular protease, PfpI family; Region: PfpI; TIGR01382 395962008459 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 395962008460 conserved cys residue [active] 395962008461 Predicted ATPase [General function prediction only]; Region: COG4637 395962008462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962008463 Walker A/P-loop; other site 395962008464 ATP binding site [chemical binding]; other site 395962008465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962008466 Q-loop/lid; other site 395962008467 ABC transporter signature motif; other site 395962008468 Walker B; other site 395962008469 D-loop; other site 395962008470 H-loop/switch region; other site 395962008471 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 395962008472 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 395962008473 oligomerisation interface [polypeptide binding]; other site 395962008474 mobile loop; other site 395962008475 roof hairpin; other site 395962008476 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 395962008477 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 395962008478 ring oligomerisation interface [polypeptide binding]; other site 395962008479 ATP/Mg binding site [chemical binding]; other site 395962008480 stacking interactions; other site 395962008481 hinge regions; other site 395962008482 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962008483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962008484 Probable transposase; Region: OrfB_IS605; pfam01385 395962008485 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962008486 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 395962008487 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 395962008488 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 395962008489 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 395962008490 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 395962008491 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 395962008492 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 395962008493 RNA binding site [nucleotide binding]; other site 395962008494 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962008495 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962008496 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962008497 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 395962008498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962008499 FeS/SAM binding site; other site 395962008500 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 395962008501 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 395962008502 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395962008503 RNA binding surface [nucleotide binding]; other site 395962008504 Transposase IS200 like; Region: Y1_Tnp; cl00848 395962008505 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395962008506 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962008507 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 395962008508 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962008509 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 395962008510 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 395962008511 Active site cavity [active] 395962008512 catalytic acid [active] 395962008513 Domain of unknown function (DUF389); Region: DUF389; cl00781 395962008514 thiamine monophosphate kinase; Provisional; Region: PRK05731 395962008515 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 395962008516 ATP binding site [chemical binding]; other site 395962008517 dimerization interface [polypeptide binding]; other site 395962008518 Protein of unknown function (DUF497); Region: DUF497; cl01108 395962008519 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 395962008520 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 395962008521 putative tRNA-binding site [nucleotide binding]; other site 395962008522 B3/4 domain; Region: B3_4; cl11458 395962008523 tRNA synthetase B5 domain; Region: B5; cl08394 395962008524 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 395962008525 dimer interface [polypeptide binding]; other site 395962008526 motif 1; other site 395962008527 motif 3; other site 395962008528 motif 2; other site 395962008529 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 395962008530 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395962008531 active site 395962008532 NTP binding site [chemical binding]; other site 395962008533 metal binding triad [ion binding]; metal-binding site 395962008534 antibiotic binding site [chemical binding]; other site 395962008535 SWIM zinc finger; Region: SWIM; cl15408 395962008536 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 395962008537 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 395962008538 SH3 domain-containing protein; Provisional; Region: PRK10884 395962008539 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 395962008540 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 395962008541 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 395962008542 putative ADP-binding pocket [chemical binding]; other site 395962008543 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962008544 Methyltransferase domain; Region: Methyltransf_31; pfam13847 395962008545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962008546 S-adenosylmethionine binding site [chemical binding]; other site 395962008547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008548 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 395962008549 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 395962008550 dimerization interface [polypeptide binding]; other site 395962008551 active site 395962008552 metal binding site [ion binding]; metal-binding site 395962008553 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 395962008554 dsRNA binding site [nucleotide binding]; other site 395962008555 Predicted transcriptional regulator [Transcription]; Region: COG2944 395962008556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395962008557 non-specific DNA binding site [nucleotide binding]; other site 395962008558 salt bridge; other site 395962008559 sequence-specific DNA binding site [nucleotide binding]; other site 395962008560 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 395962008561 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395962008562 P-loop; other site 395962008563 Magnesium ion binding site [ion binding]; other site 395962008564 chaperone protein DnaJ; Provisional; Region: PRK14299 395962008565 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395962008566 HSP70 interaction site [polypeptide binding]; other site 395962008567 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 395962008568 substrate binding site [polypeptide binding]; other site 395962008569 dimer interface [polypeptide binding]; other site 395962008570 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962008571 putative active site [active] 395962008572 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 395962008573 active site 395962008574 putative substrate binding region [chemical binding]; other site 395962008575 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 395962008576 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 395962008577 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 395962008578 putative active site [active] 395962008579 putative NTP binding site [chemical binding]; other site 395962008580 putative nucleic acid binding site [nucleotide binding]; other site 395962008581 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 395962008582 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395962008583 active site 395962008584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962008585 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 395962008586 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 395962008587 transmembrane helices; other site 395962008588 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 395962008589 Family description; Region: UvrD_C_2; cl15862 395962008590 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962008591 putative active site [active] 395962008592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 395962008593 Predicted kinase [General function prediction only]; Region: COG0645 395962008594 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 395962008595 ATP-binding site [chemical binding]; other site 395962008596 Gluconate-6-phosphate binding site [chemical binding]; other site 395962008597 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 395962008598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395962008599 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962008600 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 395962008601 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 395962008602 putative di-iron ligands [ion binding]; other site 395962008603 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395962008604 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395962008605 ligand binding site [chemical binding]; other site 395962008606 flexible hinge region; other site 395962008607 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 395962008608 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 395962008609 Zn binding site [ion binding]; other site 395962008610 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 395962008611 protein binding site [polypeptide binding]; other site 395962008612 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 395962008613 homodimer interface [polypeptide binding]; other site 395962008614 substrate-cofactor binding pocket; other site 395962008615 catalytic residue [active] 395962008616 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 395962008617 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 395962008618 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 395962008619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962008620 Walker A motif; other site 395962008621 ATP binding site [chemical binding]; other site 395962008622 Walker B motif; other site 395962008623 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 395962008624 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 395962008625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008626 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 395962008627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008628 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 395962008629 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 395962008630 cofactor binding site; other site 395962008631 DNA binding site [nucleotide binding] 395962008632 substrate interaction site [chemical binding]; other site 395962008633 Protein of unknown function, DUF488; Region: DUF488; cl01246 395962008634 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395962008635 catalytic core [active] 395962008636 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395962008637 catalytic core [active] 395962008638 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 395962008639 Phycobilisome protein; Region: Phycobilisome; cl08227 395962008640 Phycobilisome protein; Region: Phycobilisome; cl08227 395962008641 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 395962008642 Bacterial sugar transferase; Region: Bac_transf; cl00939 395962008643 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962008644 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 395962008645 putative ADP-binding pocket [chemical binding]; other site 395962008646 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395962008647 catalytic loop [active] 395962008648 iron binding site [ion binding]; other site 395962008649 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 395962008650 tetramer interface [polypeptide binding]; other site 395962008651 dimer interface [polypeptide binding]; other site 395962008652 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 395962008653 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 395962008654 Walker A motif; other site 395962008655 ATP binding site [chemical binding]; other site 395962008656 Walker B motif; other site 395962008657 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 395962008658 Transposase domain (DUF772); Region: DUF772; cl15789 395962008659 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 395962008660 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 395962008661 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 395962008662 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 395962008663 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 395962008664 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962008665 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 395962008666 active site 395962008667 ATP binding site [chemical binding]; other site 395962008668 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 395962008669 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 395962008670 Substrate binding site; other site 395962008671 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 395962008672 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 395962008673 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 395962008674 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 395962008675 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 395962008676 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 395962008677 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 395962008678 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 395962008679 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 395962008680 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 395962008681 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 395962008682 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395962008683 Uncharacterized conserved protein [Function unknown]; Region: COG5464 395962008684 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962008685 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 395962008686 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 395962008687 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395962008688 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 395962008689 Helix-turn-helix domains; Region: HTH; cl00088 395962008690 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962008691 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 395962008692 NIL domain; Region: NIL; cl09633 395962008693 sulfate transport protein; Provisional; Region: cysT; CHL00187 395962008694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962008695 dimer interface [polypeptide binding]; other site 395962008696 conserved gate region; other site 395962008697 putative PBP binding loops; other site 395962008698 ABC-ATPase subunit interface; other site 395962008699 sulfate transport protein; Provisional; Region: cysT; CHL00187 395962008700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962008701 dimer interface [polypeptide binding]; other site 395962008702 conserved gate region; other site 395962008703 putative PBP binding loops; other site 395962008704 ABC-ATPase subunit interface; other site 395962008705 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 395962008706 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 395962008707 Walker A/P-loop; other site 395962008708 ATP binding site [chemical binding]; other site 395962008709 Q-loop/lid; other site 395962008710 ABC transporter signature motif; other site 395962008711 Walker B; other site 395962008712 D-loop; other site 395962008713 H-loop/switch region; other site 395962008714 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 395962008715 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 395962008716 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 395962008717 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 395962008718 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 395962008719 Response regulator receiver domain; Region: Response_reg; pfam00072 395962008720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962008721 active site 395962008722 phosphorylation site [posttranslational modification] 395962008723 intermolecular recognition site; other site 395962008724 dimerization interface [polypeptide binding]; other site 395962008725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 395962008726 dimer interface [polypeptide binding]; other site 395962008727 phosphorylation site [posttranslational modification] 395962008728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962008729 ATP binding site [chemical binding]; other site 395962008730 Mg2+ binding site [ion binding]; other site 395962008731 G-X-G motif; other site 395962008732 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 395962008733 Amidinotransferase; Region: Amidinotransf; cl12043 395962008734 Uncharacterized conserved protein [Function unknown]; Region: COG1915 395962008735 LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455 395962008736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962008737 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 395962008738 glucokinase, proteobacterial type; Region: glk; TIGR00749 395962008739 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 395962008740 Integral membrane protein TerC family; Region: TerC; cl10468 395962008741 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 395962008742 MutS domain I; Region: MutS_I; pfam01624 395962008743 MutS domain II; Region: MutS_II; pfam05188 395962008744 MutS family domain IV; Region: MutS_IV; pfam05190 395962008745 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 395962008746 Walker A/P-loop; other site 395962008747 ATP binding site [chemical binding]; other site 395962008748 Q-loop/lid; other site 395962008749 ABC transporter signature motif; other site 395962008750 Walker B; other site 395962008751 D-loop; other site 395962008752 H-loop/switch region; other site 395962008753 Methyltransferase domain; Region: Methyltransf_31; pfam13847 395962008754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962008755 S-adenosylmethionine binding site [chemical binding]; other site 395962008756 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395962008757 ligand binding site [chemical binding]; other site 395962008758 flexible hinge region; other site 395962008759 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 395962008760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962008761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962008762 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 395962008763 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395962008764 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 395962008765 active site 395962008766 Ca binding site [ion binding]; other site 395962008767 catalytic site [active] 395962008768 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 395962008769 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 395962008770 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 395962008771 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 395962008772 Walker A/P-loop; other site 395962008773 ATP binding site [chemical binding]; other site 395962008774 Q-loop/lid; other site 395962008775 ABC transporter signature motif; other site 395962008776 Walker B; other site 395962008777 D-loop; other site 395962008778 H-loop/switch region; other site 395962008779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395962008780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 395962008781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962008782 dimer interface [polypeptide binding]; other site 395962008783 phosphorylation site [posttranslational modification] 395962008784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962008785 ATP binding site [chemical binding]; other site 395962008786 Mg2+ binding site [ion binding]; other site 395962008787 G-X-G motif; other site 395962008788 Peptidase family M48; Region: Peptidase_M48; cl12018 395962008789 Low molecular weight phosphatase family; Region: LMWPc; cd00115 395962008790 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 395962008791 active site 395962008792 ATP synthase; Region: ATP-synt; cl00365 395962008793 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 395962008794 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 395962008795 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 395962008796 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 395962008797 beta subunit interaction interface [polypeptide binding]; other site 395962008798 Walker A motif; other site 395962008799 ATP binding site [chemical binding]; other site 395962008800 Walker B motif; other site 395962008801 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 395962008802 Plant ATP synthase F0; Region: YMF19; cl07975 395962008803 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 395962008804 Plant ATP synthase F0; Region: YMF19; cl07975 395962008805 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 395962008806 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 395962008807 Plant ATP synthase F0; Region: YMF19; cl07975 395962008808 ATP synthase subunit C; Region: ATP-synt_C; cl00466 395962008809 ATP synthase A chain; Region: ATP-synt_A; cl00413 395962008810 ATP synthase I chain; Region: ATP_synt_I; cl09170 395962008811 ribosome maturation protein RimP; Reviewed; Region: PRK00092 395962008812 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 395962008813 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 395962008814 Sm1 motif; other site 395962008815 D3 - B interaction site; other site 395962008816 D1 - D2 interaction site; other site 395962008817 Hfq - Hfq interaction site; other site 395962008818 RNA binding pocket [nucleotide binding]; other site 395962008819 Sm2 motif; other site 395962008820 transcription elongation factor NusA; Provisional; Region: nusA; PRK12329 395962008821 NusA N-terminal domain; Region: NusA_N; pfam08529 395962008822 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 395962008823 RNA binding site [nucleotide binding]; other site 395962008824 homodimer interface [polypeptide binding]; other site 395962008825 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 395962008826 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 395962008827 G-X-X-G motif; other site 395962008828 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 395962008829 putative RNA binding cleft [nucleotide binding]; other site 395962008830 translation initiation factor IF-2; Validated; Region: infB; PRK05306 395962008831 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 395962008832 translation initiation factor IF-2; Region: IF-2; TIGR00487 395962008833 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 395962008834 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 395962008835 G1 box; other site 395962008836 putative GEF interaction site [polypeptide binding]; other site 395962008837 GTP/Mg2+ binding site [chemical binding]; other site 395962008838 Switch I region; other site 395962008839 G2 box; other site 395962008840 G3 box; other site 395962008841 Switch II region; other site 395962008842 G4 box; other site 395962008843 G5 box; other site 395962008844 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 395962008845 Translation-initiation factor 2; Region: IF-2; pfam11987 395962008846 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 395962008847 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 395962008848 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 395962008849 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 395962008850 HIGH motif; other site 395962008851 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 395962008852 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 395962008853 active site 395962008854 KMSKS motif; other site 395962008855 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 395962008856 tRNA binding surface [nucleotide binding]; other site 395962008857 anticodon binding site; other site 395962008858 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 395962008859 Predicted ATPase [General function prediction only]; Region: COG4637 395962008860 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962008861 Walker A/P-loop; other site 395962008862 ATP binding site [chemical binding]; other site 395962008863 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 395962008864 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 395962008865 nucleoside/Zn binding site; other site 395962008866 dimer interface [polypeptide binding]; other site 395962008867 catalytic motif [active] 395962008868 TIR domain; Region: TIR_2; cl15770 395962008869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962008870 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 395962008871 Walker A/P-loop; other site 395962008872 ATP binding site [chemical binding]; other site 395962008873 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395962008874 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 395962008875 active site 395962008876 metal binding site [ion binding]; metal-binding site 395962008877 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962008878 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962008879 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008880 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008881 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008882 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008883 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008884 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008885 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 395962008886 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 395962008887 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 395962008888 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962008889 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008890 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008891 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008892 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962008893 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 395962008894 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 395962008895 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 395962008896 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 395962008897 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 395962008898 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 395962008899 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962008900 putative active site [active] 395962008901 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 395962008902 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 395962008903 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 395962008904 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 395962008905 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 395962008906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962008907 FeS/SAM binding site; other site 395962008908 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 395962008909 Phosphotransferase enzyme family; Region: APH; pfam01636 395962008910 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962008911 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 395962008912 PPIC-type PPIASE domain; Region: Rotamase; cl08278 395962008913 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 395962008914 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962008915 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962008916 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 395962008917 ligand binding site [chemical binding]; other site 395962008918 flexible hinge region; other site 395962008919 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 395962008920 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 395962008921 putative active site [active] 395962008922 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 395962008923 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 395962008924 Walker A/P-loop; other site 395962008925 ATP binding site [chemical binding]; other site 395962008926 Q-loop/lid; other site 395962008927 ABC transporter signature motif; other site 395962008928 Walker B; other site 395962008929 D-loop; other site 395962008930 H-loop/switch region; other site 395962008931 Helix-turn-helix domains; Region: HTH; cl00088 395962008932 Winged helix-turn helix; Region: HTH_29; pfam13551 395962008933 Winged helix-turn helix; Region: HTH_33; pfam13592 395962008934 AAA domain; Region: AAA_26; pfam13500 395962008935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962008936 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 395962008937 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 395962008938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962008939 active site 395962008940 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 395962008941 TPR repeat; Region: TPR_11; pfam13414 395962008942 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962008943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962008944 TPR motif; other site 395962008945 binding surface 395962008946 TPR repeat; Region: TPR_11; pfam13414 395962008947 Protein of unknown function; Region: DUF3971; pfam13116 395962008948 Family of unknown function (DUF490); Region: DUF490; pfam04357 395962008949 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 395962008950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395962008951 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 395962008952 substrate binding pocket [chemical binding]; other site 395962008953 membrane-bound complex binding site; other site 395962008954 hinge residues; other site 395962008955 Domain of unknown function DUF20; Region: UPF0118; pfam01594 395962008956 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 395962008957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962008958 ABC-ATPase subunit interface; other site 395962008959 putative PBP binding loops; other site 395962008960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 395962008961 Circadian oscillating protein COP23; Region: COP23; pfam14218 395962008962 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 395962008963 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 395962008964 putative active site [active] 395962008965 ThiC family; Region: ThiC; cl08031 395962008966 XisI protein; Region: XisI; pfam08869 395962008967 MEKHLA domain; Region: MEKHLA; pfam08670 395962008968 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395962008969 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395962008970 P-loop; other site 395962008971 Magnesium ion binding site [ion binding]; other site 395962008972 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962008973 phosphopeptide binding site; other site 395962008974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962008975 metal binding site [ion binding]; metal-binding site 395962008976 active site 395962008977 I-site; other site 395962008978 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962008979 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962008980 phosphopeptide binding site; other site 395962008981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962008982 metal binding site [ion binding]; metal-binding site 395962008983 active site 395962008984 I-site; other site 395962008985 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962008986 Protein of function (DUF2518); Region: DUF2518; pfam10726 395962008987 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 395962008988 AIR carboxylase; Region: AIRC; cl00310 395962008989 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 395962008990 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 395962008991 Catalytic site [active] 395962008992 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 395962008993 histidinol dehydrogenase; Region: hisD; TIGR00069 395962008994 NAD binding site [chemical binding]; other site 395962008995 dimerization interface [polypeptide binding]; other site 395962008996 product binding site; other site 395962008997 substrate binding site [chemical binding]; other site 395962008998 zinc binding site [ion binding]; other site 395962008999 catalytic residues [active] 395962009000 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395962009001 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 395962009002 substrate binding pocket [chemical binding]; other site 395962009003 membrane-bound complex binding site; other site 395962009004 hinge residues; other site 395962009005 Ycf46; Provisional; Region: ycf46; CHL00195 395962009006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395962009007 Walker A motif; other site 395962009008 ATP binding site [chemical binding]; other site 395962009009 Walker B motif; other site 395962009010 arginine finger; other site 395962009011 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 395962009012 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 395962009013 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 395962009014 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 395962009015 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962009016 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 395962009017 nudix motif; other site 395962009018 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 395962009019 N- and C-terminal domain interface [polypeptide binding]; other site 395962009020 D-xylulose kinase; Region: XylB; TIGR01312 395962009021 active site 395962009022 MgATP binding site [chemical binding]; other site 395962009023 catalytic site [active] 395962009024 metal binding site [ion binding]; metal-binding site 395962009025 carbohydrate binding site [chemical binding]; other site 395962009026 Integral membrane protein DUF92; Region: DUF92; cl00793 395962009027 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 395962009028 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 395962009029 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 395962009030 putative dimer interface [polypeptide binding]; other site 395962009031 NlpC/P60 family; Region: NLPC_P60; cl11438 395962009032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962009033 Coenzyme A binding pocket [chemical binding]; other site 395962009034 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 395962009035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962009036 dimer interface [polypeptide binding]; other site 395962009037 phosphorylation site [posttranslational modification] 395962009038 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 395962009039 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962009040 putative active site [active] 395962009041 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 395962009042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962009043 Tup N-terminal; Region: Tup_N; pfam08581 395962009044 MASE1; Region: MASE1; pfam05231 395962009045 GAF domain; Region: GAF; cl15785 395962009046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395962009047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962009048 dimer interface [polypeptide binding]; other site 395962009049 phosphorylation site [posttranslational modification] 395962009050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962009051 ATP binding site [chemical binding]; other site 395962009052 Mg2+ binding site [ion binding]; other site 395962009053 G-X-G motif; other site 395962009054 Response regulator receiver domain; Region: Response_reg; pfam00072 395962009055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009056 active site 395962009057 phosphorylation site [posttranslational modification] 395962009058 intermolecular recognition site; other site 395962009059 dimerization interface [polypeptide binding]; other site 395962009060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395962009061 DNA binding residues [nucleotide binding] 395962009062 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 395962009063 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962009064 putative active site [active] 395962009065 Protein of unknown function DUF262; Region: DUF262; cl14890 395962009066 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 395962009067 catalytic motif [active] 395962009068 Catalytic residue [active] 395962009069 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 395962009070 heat shock protein 90; Provisional; Region: PRK05218 395962009071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962009072 ATP binding site [chemical binding]; other site 395962009073 Mg2+ binding site [ion binding]; other site 395962009074 G-X-G motif; other site 395962009075 Domain of unknown function DUF21; Region: DUF21; pfam01595 395962009076 FOG: CBS domain [General function prediction only]; Region: COG0517 395962009077 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 395962009078 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 395962009079 LytB protein; Region: LYTB; cl00507 395962009080 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 395962009081 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 395962009082 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 395962009083 ribosomal protein L20; Region: rpl20; CHL00068 395962009084 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 395962009085 23S rRNA binding site [nucleotide binding]; other site 395962009086 L21 binding site [polypeptide binding]; other site 395962009087 L13 binding site [polypeptide binding]; other site 395962009088 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 395962009089 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 395962009090 Flavin Reductases; Region: FlaRed; cl00801 395962009091 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 395962009092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962009093 FeS/SAM binding site; other site 395962009094 HemN C-terminal domain; Region: HemN_C; pfam06969 395962009095 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 395962009096 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 395962009097 putative active site [active] 395962009098 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 395962009099 CAAX protease self-immunity; Region: Abi; cl00558 395962009100 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 395962009101 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962009102 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962009103 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395962009104 NurA domain; Region: NurA; cl09134 395962009105 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 395962009106 substrate binding site [chemical binding]; other site 395962009107 electron transport complex protein RnfB; Provisional; Region: PRK05113 395962009108 ABC-2 type transporter; Region: ABC2_membrane; cl11417 395962009109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962009110 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 395962009111 Walker A/P-loop; other site 395962009112 ATP binding site [chemical binding]; other site 395962009113 Q-loop/lid; other site 395962009114 ABC transporter signature motif; other site 395962009115 Walker B; other site 395962009116 D-loop; other site 395962009117 H-loop/switch region; other site 395962009118 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 395962009119 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395962009120 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962009121 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962009122 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 395962009123 pyruvate kinase; Provisional; Region: PRK06354 395962009124 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 395962009125 domain interfaces; other site 395962009126 active site 395962009127 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 395962009128 Protein of unknown function (DUF433); Region: DUF433; cl01030 395962009129 elongation factor Ts; Reviewed; Region: tsf; PRK12332 395962009130 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 395962009131 Elongation factor TS; Region: EF_TS; pfam00889 395962009132 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 395962009133 rRNA interaction site [nucleotide binding]; other site 395962009134 S8 interaction site; other site 395962009135 putative laminin-1 binding site; other site 395962009136 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 395962009137 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 395962009138 ATP-binding site [chemical binding]; other site 395962009139 Gluconate-6-phosphate binding site [chemical binding]; other site 395962009140 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 395962009141 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 395962009142 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 395962009143 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 395962009144 Cache domain; Region: Cache_1; pfam02743 395962009145 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 395962009146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962009147 PAS domain; Region: PAS_9; pfam13426 395962009148 putative active site [active] 395962009149 heme pocket [chemical binding]; other site 395962009150 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 395962009151 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 395962009152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 395962009153 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 395962009154 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 395962009155 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 395962009156 Protein of unknown function (DUF952); Region: DUF952; cl01393 395962009157 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 395962009158 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 395962009159 NADP binding site [chemical binding]; other site 395962009160 active site 395962009161 putative substrate binding site [chemical binding]; other site 395962009162 GDP-mannose 4,6-dehydratase; Region: PLN02653 395962009163 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 395962009164 NADP-binding site; other site 395962009165 homotetramer interface [polypeptide binding]; other site 395962009166 substrate binding site [chemical binding]; other site 395962009167 homodimer interface [polypeptide binding]; other site 395962009168 active site 395962009169 ribosome recycling factor; Reviewed; Region: frr; PRK00083 395962009170 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 395962009171 hinge region; other site 395962009172 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 395962009173 putative nucleotide binding site [chemical binding]; other site 395962009174 uridine monophosphate binding site [chemical binding]; other site 395962009175 homohexameric interface [polypeptide binding]; other site 395962009176 GUN4-like; Region: GUN4; pfam05419 395962009177 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 395962009178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962009179 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 395962009180 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 395962009181 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 395962009182 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395962009183 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395962009184 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 395962009185 FAD binding domain; Region: FAD_binding_4; pfam01565 395962009186 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 395962009187 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 395962009188 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 395962009189 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 395962009190 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 395962009191 PhoU domain; Region: PhoU; pfam01895 395962009192 PhoU domain; Region: PhoU; pfam01895 395962009193 calcium/proton exchanger (cax); Region: cax; TIGR00378 395962009194 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 395962009195 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 395962009196 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 395962009197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962009198 ATP binding site [chemical binding]; other site 395962009199 Mg2+ binding site [ion binding]; other site 395962009200 G-X-G motif; other site 395962009201 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 395962009202 Response regulator receiver domain; Region: Response_reg; pfam00072 395962009203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009204 active site 395962009205 phosphorylation site [posttranslational modification] 395962009206 intermolecular recognition site; other site 395962009207 dimerization interface [polypeptide binding]; other site 395962009208 Response regulator receiver domain; Region: Response_reg; pfam00072 395962009209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009210 active site 395962009211 phosphorylation site [posttranslational modification] 395962009212 intermolecular recognition site; other site 395962009213 dimerization interface [polypeptide binding]; other site 395962009214 GTPase Era; Reviewed; Region: era; PRK00089 395962009215 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 395962009216 G1 box; other site 395962009217 GTP/Mg2+ binding site [chemical binding]; other site 395962009218 Switch I region; other site 395962009219 G2 box; other site 395962009220 Switch II region; other site 395962009221 G3 box; other site 395962009222 G4 box; other site 395962009223 G5 box; other site 395962009224 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 395962009225 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 395962009226 putative active site [active] 395962009227 putative metal binding residues [ion binding]; other site 395962009228 signature motif; other site 395962009229 putative dimer interface [polypeptide binding]; other site 395962009230 putative phosphate binding site [ion binding]; other site 395962009231 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 395962009232 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 395962009233 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 395962009234 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 395962009235 dimerization interface [polypeptide binding]; other site 395962009236 FAD binding pocket [chemical binding]; other site 395962009237 FAD binding motif [chemical binding]; other site 395962009238 catalytic residues [active] 395962009239 NAD binding pocket [chemical binding]; other site 395962009240 phosphate binding motif [ion binding]; other site 395962009241 beta-alpha-beta structure motif; other site 395962009242 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 395962009243 Domain of unknown function DUF39; Region: DUF39; cl14897 395962009244 RNA polymerase sigma factor; Validated; Region: PRK05949 395962009245 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 395962009246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395962009247 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 395962009248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395962009249 DNA binding residues [nucleotide binding] 395962009250 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 395962009251 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 395962009252 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962009253 putative active site [active] 395962009254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962009255 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 395962009256 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 395962009257 homodimer interface [polypeptide binding]; other site 395962009258 Walker A motif; other site 395962009259 ATP binding site [chemical binding]; other site 395962009260 hydroxycobalamin binding site [chemical binding]; other site 395962009261 Walker B motif; other site 395962009262 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 395962009263 Maf-like protein; Region: Maf; pfam02545 395962009264 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 395962009265 active site 395962009266 dimer interface [polypeptide binding]; other site 395962009267 PsbP; Region: PsbP; cl03356 395962009268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962009269 TPR repeat; Region: TPR_11; pfam13414 395962009270 binding surface 395962009271 TPR motif; other site 395962009272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962009273 binding surface 395962009274 TPR motif; other site 395962009275 TPR repeat; Region: TPR_11; pfam13414 395962009276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962009277 GTP-binding protein LepA; Provisional; Region: PRK05433 395962009278 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 395962009279 G1 box; other site 395962009280 putative GEF interaction site [polypeptide binding]; other site 395962009281 GTP/Mg2+ binding site [chemical binding]; other site 395962009282 Switch I region; other site 395962009283 G2 box; other site 395962009284 G3 box; other site 395962009285 Switch II region; other site 395962009286 G4 box; other site 395962009287 G5 box; other site 395962009288 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 395962009289 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 395962009290 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 395962009291 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 395962009292 Domain of unknown function (DUF697); Region: DUF697; cl12064 395962009293 2TM domain; Region: 2TM; pfam13239 395962009294 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009295 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009296 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 395962009297 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 395962009298 Domain of unknown function DUF20; Region: UPF0118; pfam01594 395962009299 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 395962009300 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 395962009301 YGGT family; Region: YGGT; cl00508 395962009302 CAAX protease self-immunity; Region: Abi; cl00558 395962009303 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 395962009304 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962009305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395962009306 catalytic core [active] 395962009307 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395962009308 catalytic core [active] 395962009309 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962009310 putative active site [active] 395962009311 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 395962009312 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 395962009313 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 395962009314 Nucleotide binding site [chemical binding]; other site 395962009315 DTAP/Switch II; other site 395962009316 Switch I; other site 395962009317 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 395962009318 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 395962009319 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 395962009320 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 395962009321 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 395962009322 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395962009323 inhibitor-cofactor binding pocket; inhibition site 395962009324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962009325 catalytic residue [active] 395962009326 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 395962009327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962009328 dimer interface [polypeptide binding]; other site 395962009329 ABC-ATPase subunit interface; other site 395962009330 putative PBP binding loops; other site 395962009331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 395962009332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 395962009333 cofactor binding site; other site 395962009334 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962009335 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009336 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009337 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 395962009338 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 395962009339 TPP-binding site [chemical binding]; other site 395962009340 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 395962009341 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 395962009342 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 395962009343 dephospho-CoA kinase; Region: TIGR00152 395962009344 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 395962009345 CoA-binding site [chemical binding]; other site 395962009346 ATP-binding [chemical binding]; other site 395962009347 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962009348 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 395962009349 hydrophobic ligand binding site; other site 395962009350 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 395962009351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962009352 S-adenosylmethionine binding site [chemical binding]; other site 395962009353 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 395962009354 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 395962009355 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 395962009356 substrate binding pocket [chemical binding]; other site 395962009357 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 395962009358 B12 binding site [chemical binding]; other site 395962009359 cobalt ligand [ion binding]; other site 395962009360 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 395962009361 Transposase IS200 like; Region: Y1_Tnp; cl00848 395962009362 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 395962009363 MatE; Region: MatE; cl10513 395962009364 MatE; Region: MatE; cl10513 395962009365 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 395962009366 DHH family; Region: DHH; pfam01368 395962009367 DHHA1 domain; Region: DHHA1; pfam02272 395962009368 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 395962009369 active site 395962009370 putative lithium-binding site [ion binding]; other site 395962009371 substrate binding site [chemical binding]; other site 395962009372 CHAD domain; Region: CHAD; cl10506 395962009373 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 395962009374 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 395962009375 TPR repeat; Region: TPR_11; pfam13414 395962009376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962009377 binding surface 395962009378 TPR motif; other site 395962009379 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962009380 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962009381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 395962009382 CHAT domain; Region: CHAT; pfam12770 395962009383 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962009384 YcfA-like protein; Region: YcfA; cl00752 395962009385 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 395962009386 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 395962009387 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 395962009388 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 395962009389 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 395962009390 metal binding site [ion binding]; metal-binding site 395962009391 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 395962009392 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 395962009393 [2Fe-2S] cluster binding site [ion binding]; other site 395962009394 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 395962009395 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 395962009396 YokU-like protein; Region: YokU; cl15819 395962009397 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 395962009398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 395962009399 active site 395962009400 Uncharacterized conserved protein [Function unknown]; Region: COG2912 395962009401 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 395962009402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962009403 binding surface 395962009404 TPR motif; other site 395962009405 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 395962009406 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395962009407 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 395962009408 N-terminal domain interface [polypeptide binding]; other site 395962009409 dimer interface [polypeptide binding]; other site 395962009410 substrate binding pocket (H-site) [chemical binding]; other site 395962009411 YCF9; Region: Ycf9; cl09269 395962009412 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 395962009413 homopentamer interface [polypeptide binding]; other site 395962009414 active site 395962009415 hypothetical protein; Provisional; Region: PRK07394 395962009416 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 395962009417 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 395962009418 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 395962009419 HEAT repeats; Region: HEAT_2; pfam13646 395962009420 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 395962009421 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395962009422 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395962009423 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 395962009424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395962009425 putative substrate translocation pore; other site 395962009426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395962009427 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 395962009428 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962009429 putative active site [active] 395962009430 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 395962009431 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962009432 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 395962009433 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 395962009434 [4Fe-4S] binding site [ion binding]; other site 395962009435 molybdopterin cofactor binding site; other site 395962009436 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 395962009437 molybdopterin cofactor binding site; other site 395962009438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395962009439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 395962009440 CHAT domain; Region: CHAT; pfam12770 395962009441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 395962009442 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 395962009443 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962009444 putative active site [active] 395962009445 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 395962009446 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 395962009447 putative valine binding site [chemical binding]; other site 395962009448 dimer interface [polypeptide binding]; other site 395962009449 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 395962009450 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 395962009451 Protein kinase domain; Region: Pkinase; pfam00069 395962009452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962009453 active site 395962009454 ATP binding site [chemical binding]; other site 395962009455 substrate binding site [chemical binding]; other site 395962009456 activation loop (A-loop); other site 395962009457 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395962009458 Ligand Binding Site [chemical binding]; other site 395962009459 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395962009460 Ligand Binding Site [chemical binding]; other site 395962009461 Domain of unknown function DUF; Region: DUF204; pfam02659 395962009462 Domain of unknown function DUF; Region: DUF204; pfam02659 395962009463 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 395962009464 dimer interface [polypeptide binding]; other site 395962009465 [2Fe-2S] cluster binding site [ion binding]; other site 395962009466 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 395962009467 Ferritin-like domain; Region: Ferritin; pfam00210 395962009468 dimerization interface [polypeptide binding]; other site 395962009469 DPS ferroxidase diiron center [ion binding]; other site 395962009470 ion pore; other site 395962009471 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962009472 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 395962009473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962009474 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 395962009475 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962009476 putative active site [active] 395962009477 Ion transport protein; Region: Ion_trans; pfam00520 395962009478 Ion channel; Region: Ion_trans_2; cl11596 395962009479 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 395962009480 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962009481 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 395962009482 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 395962009483 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 395962009484 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 395962009485 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962009486 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 395962009487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962009488 Coenzyme A binding pocket [chemical binding]; other site 395962009489 Restriction endonuclease; Region: Mrr_cat; cl00516 395962009490 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 395962009491 Family description; Region: UvrD_C_2; cl15862 395962009492 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962009493 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009494 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009495 Protein of unknown function (DUF497); Region: DUF497; cl01108 395962009496 Lipoxygenase; Region: Lipoxygenase; pfam00305 395962009497 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 395962009498 PKC phosphorylation site [posttranslational modification]; other site 395962009499 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 395962009500 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 395962009501 Penicillin amidase; Region: Penicil_amidase; pfam01804 395962009502 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 395962009503 active site 395962009504 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 395962009505 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 395962009506 Domain of unknown function DUF21; Region: DUF21; pfam01595 395962009507 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 395962009508 Transporter associated domain; Region: CorC_HlyC; cl08393 395962009509 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395962009510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009511 active site 395962009512 phosphorylation site [posttranslational modification] 395962009513 intermolecular recognition site; other site 395962009514 dimerization interface [polypeptide binding]; other site 395962009515 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395962009516 DNA binding residues [nucleotide binding] 395962009517 dimerization interface [polypeptide binding]; other site 395962009518 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 395962009519 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 395962009520 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 395962009521 thioester formation/cholesterol transfer; other site 395962009522 protein-splicing catalytic site; other site 395962009523 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 395962009524 active site 395962009525 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 395962009526 active site 395962009527 Domain of unknown function (DUF4308); Region: DUF4308; cl14566 395962009528 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 395962009529 dimerization interface [polypeptide binding]; other site 395962009530 active site 395962009531 metal binding site [ion binding]; metal-binding site 395962009532 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395962009533 anti sigma factor interaction site; other site 395962009534 regulatory phosphorylation site [posttranslational modification]; other site 395962009535 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395962009536 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962009537 active site 395962009538 ATP binding site [chemical binding]; other site 395962009539 substrate binding site [chemical binding]; other site 395962009540 activation loop (A-loop); other site 395962009541 NeuB family; Region: NeuB; cl00496 395962009542 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 395962009543 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 395962009544 dimer interface [polypeptide binding]; other site 395962009545 [2Fe-2S] cluster binding site [ion binding]; other site 395962009546 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 395962009547 Domain of unknown function DUF87; Region: DUF87; pfam01935 395962009548 AAA-like domain; Region: AAA_10; pfam12846 395962009549 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 395962009550 Cupin domain; Region: Cupin_2; cl09118 395962009551 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 395962009552 Protein of unknown function DUF111; Region: DUF111; cl03398 395962009553 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 395962009554 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 395962009555 putative acyl-acceptor binding pocket; other site 395962009556 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395962009557 endonuclease III; Region: ENDO3c; smart00478 395962009558 minor groove reading motif; other site 395962009559 helix-hairpin-helix signature motif; other site 395962009560 substrate binding pocket [chemical binding]; other site 395962009561 active site 395962009562 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 395962009563 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 395962009564 Tetratricopeptide repeat; Region: TPR_6; pfam13174 395962009565 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 395962009566 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 395962009567 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395962009568 catalytic residue [active] 395962009569 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 395962009570 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 395962009571 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962009572 putative active site [active] 395962009573 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 395962009574 FOG: CBS domain [General function prediction only]; Region: COG0517 395962009575 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 395962009576 CP12 domain; Region: CP12; cl14670 395962009577 Staphylococcal nuclease homologues; Region: SNc; smart00318 395962009578 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 395962009579 Catalytic site; other site 395962009580 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 395962009581 putative active site [active] 395962009582 catalytic residue [active] 395962009583 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793 395962009584 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 395962009585 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 395962009586 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 395962009587 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 395962009588 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 395962009589 alpha subunit interaction interface [polypeptide binding]; other site 395962009590 Walker A motif; other site 395962009591 ATP binding site [chemical binding]; other site 395962009592 Walker B motif; other site 395962009593 inhibitor binding site; inhibition site 395962009594 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 395962009595 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 395962009596 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 395962009597 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 395962009598 nudix motif; other site 395962009599 argininosuccinate lyase; Provisional; Region: PRK00855 395962009600 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 395962009601 active sites [active] 395962009602 tetramer interface [polypeptide binding]; other site 395962009603 GAF domain; Region: GAF; cl15785 395962009604 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 395962009605 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 395962009606 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 395962009607 Response regulator receiver domain; Region: Response_reg; pfam00072 395962009608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009609 active site 395962009610 phosphorylation site [posttranslational modification] 395962009611 intermolecular recognition site; other site 395962009612 dimerization interface [polypeptide binding]; other site 395962009613 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962009614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009615 active site 395962009616 phosphorylation site [posttranslational modification] 395962009617 intermolecular recognition site; other site 395962009618 dimerization interface [polypeptide binding]; other site 395962009619 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962009620 DNA binding site [nucleotide binding] 395962009621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009622 active site 395962009623 phosphorylation site [posttranslational modification] 395962009624 intermolecular recognition site; other site 395962009625 dimerization interface [polypeptide binding]; other site 395962009626 Response regulator receiver domain; Region: Response_reg; pfam00072 395962009627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009628 active site 395962009629 phosphorylation site [posttranslational modification] 395962009630 intermolecular recognition site; other site 395962009631 dimerization interface [polypeptide binding]; other site 395962009632 excinuclease ABC subunit B; Provisional; Region: PRK05298 395962009633 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962009634 ATP binding site [chemical binding]; other site 395962009635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395962009636 nucleotide binding region [chemical binding]; other site 395962009637 ATP-binding site [chemical binding]; other site 395962009638 Ultra-violet resistance protein B; Region: UvrB; pfam12344 395962009639 UvrB/uvrC motif; Region: UVR; pfam02151 395962009640 HlyD family secretion protein; Region: HlyD; pfam00529 395962009641 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395962009642 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962009643 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 395962009644 Protein export membrane protein; Region: SecD_SecF; cl14618 395962009645 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 395962009646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962009647 dimer interface [polypeptide binding]; other site 395962009648 phosphorylation site [posttranslational modification] 395962009649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962009650 ATP binding site [chemical binding]; other site 395962009651 Mg2+ binding site [ion binding]; other site 395962009652 G-X-G motif; other site 395962009653 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 395962009654 active site 395962009655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962009656 dimer interface [polypeptide binding]; other site 395962009657 conserved gate region; other site 395962009658 putative PBP binding loops; other site 395962009659 ABC-ATPase subunit interface; other site 395962009660 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 395962009661 NMT1-like family; Region: NMT1_2; cl15260 395962009662 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 395962009663 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 395962009664 Walker A/P-loop; other site 395962009665 ATP binding site [chemical binding]; other site 395962009666 Q-loop/lid; other site 395962009667 ABC transporter signature motif; other site 395962009668 Walker B; other site 395962009669 D-loop; other site 395962009670 H-loop/switch region; other site 395962009671 AMIN domain; Region: AMIN; pfam11741 395962009672 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 395962009673 active site 395962009674 metal binding site [ion binding]; metal-binding site 395962009675 UbiA prenyltransferase family; Region: UbiA; cl00337 395962009676 H+ Antiporter protein; Region: 2A0121; TIGR00900 395962009677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395962009678 putative substrate translocation pore; other site 395962009679 Condensation domain; Region: Condensation; pfam00668 395962009680 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395962009681 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962009682 AMP-binding enzyme; Region: AMP-binding; cl15778 395962009683 PilZ domain; Region: PilZ; cl01260 395962009684 peptide synthase; Provisional; Region: PRK12316 395962009685 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962009686 Condensation domain; Region: Condensation; pfam00668 395962009687 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395962009688 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962009689 AMP-binding enzyme; Region: AMP-binding; cl15778 395962009690 PilZ domain; Region: PilZ; cl01260 395962009691 peptide synthase; Provisional; Region: PRK12316 395962009692 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962009693 Condensation domain; Region: Condensation; pfam00668 395962009694 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395962009695 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962009696 AMP-binding enzyme; Region: AMP-binding; cl15778 395962009697 PilZ domain; Region: PilZ; cl01260 395962009698 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 395962009699 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962009700 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 395962009701 peptide synthase; Provisional; Region: PRK12467 395962009702 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962009703 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 395962009704 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 395962009705 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962009706 Condensation domain; Region: Condensation; pfam00668 395962009707 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395962009708 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962009709 AMP-binding enzyme; Region: AMP-binding; cl15778 395962009710 PilZ domain; Region: PilZ; cl01260 395962009711 peptide synthase; Provisional; Region: PRK12467 395962009712 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962009713 Condensation domain; Region: Condensation; pfam00668 395962009714 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395962009715 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962009716 AMP-binding enzyme; Region: AMP-binding; cl15778 395962009717 PilZ domain; Region: PilZ; cl01260 395962009718 peptide synthase; Provisional; Region: PRK12316 395962009719 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962009720 Condensation domain; Region: Condensation; pfam00668 395962009721 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395962009722 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395962009723 AMP-binding enzyme; Region: AMP-binding; cl15778 395962009724 PilZ domain; Region: PilZ; cl01260 395962009725 peptide synthase; Provisional; Region: PRK12467 395962009726 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962009727 acyl-CoA synthetase; Validated; Region: PRK05850 395962009728 AMP-binding enzyme; Region: AMP-binding; cl15778 395962009729 Phosphopantetheine attachment site; Region: PP-binding; cl09936 395962009730 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 395962009731 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 395962009732 dimerization interface [polypeptide binding]; other site 395962009733 ATP binding site [chemical binding]; other site 395962009734 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 395962009735 dimerization interface [polypeptide binding]; other site 395962009736 ATP binding site [chemical binding]; other site 395962009737 Mrr N-terminal domain; Region: Mrr_N; pfam14338 395962009738 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 395962009739 Restriction endonuclease; Region: Mrr_cat; cl00516 395962009740 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962009741 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962009742 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395962009743 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 395962009744 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 395962009745 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962009746 putative active site [active] 395962009747 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 395962009748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962009749 FeS/SAM binding site; other site 395962009750 TMAO/DMSO reductase; Reviewed; Region: PRK05363 395962009751 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 395962009752 Moco binding site; other site 395962009753 metal coordination site [ion binding]; other site 395962009754 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 395962009755 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 395962009756 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395962009757 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 395962009758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962009759 motif II; other site 395962009760 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 395962009761 CemA family; Region: CemA; cl03855 395962009762 thioester reductase domain; Region: Thioester-redct; TIGR01746 395962009763 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 395962009764 putative NAD(P) binding site [chemical binding]; other site 395962009765 active site 395962009766 putative substrate binding site [chemical binding]; other site 395962009767 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395962009768 dimerization interface [polypeptide binding]; other site 395962009769 putative DNA binding site [nucleotide binding]; other site 395962009770 putative Zn2+ binding site [ion binding]; other site 395962009771 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962009772 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009773 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009774 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009775 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962009776 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009777 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009778 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 395962009779 diiron binding motif [ion binding]; other site 395962009780 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 395962009781 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 395962009782 active site 395962009783 catalytic residues [active] 395962009784 PemK-like protein; Region: PemK; cl00995 395962009785 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 395962009786 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 395962009787 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 395962009788 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 395962009789 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 395962009790 generic binding surface I; other site 395962009791 generic binding surface II; other site 395962009792 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 395962009793 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 395962009794 Probable Catalytic site; other site 395962009795 metal-binding site 395962009796 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962009797 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 395962009798 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395962009799 short chain dehydrogenase; Provisional; Region: PRK06197 395962009800 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 395962009801 putative NAD(P) binding site [chemical binding]; other site 395962009802 active site 395962009803 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 395962009804 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 395962009805 aromatic acid decarboxylase; Validated; Region: PRK05920 395962009806 Flavoprotein; Region: Flavoprotein; cl08021 395962009807 ubiquitin-activating enzyme E1; Region: Ube1; TIGR01408 395962009808 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 395962009809 catalytic triad [active] 395962009810 conserved cis-peptide bond; other site 395962009811 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 395962009812 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 395962009813 putative NAD(P) binding site [chemical binding]; other site 395962009814 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 395962009815 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 395962009816 active site 395962009817 dimer interface [polypeptide binding]; other site 395962009818 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 395962009819 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 395962009820 active site 395962009821 FMN binding site [chemical binding]; other site 395962009822 substrate binding site [chemical binding]; other site 395962009823 3Fe-4S cluster binding site [ion binding]; other site 395962009824 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 395962009825 domain interface; other site 395962009826 Protein of unknown function (DUF497); Region: DUF497; cl01108 395962009827 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 395962009828 conserved hypothetical protein; Region: QEGLA; TIGR02421 395962009829 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 395962009830 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395962009831 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962009832 putative active site [active] 395962009833 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 395962009834 DHH family; Region: DHH; pfam01368 395962009835 FOG: CBS domain [General function prediction only]; Region: COG0517 395962009836 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 395962009837 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 395962009838 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 395962009839 active site 395962009840 NTP binding site [chemical binding]; other site 395962009841 metal binding triad [ion binding]; metal-binding site 395962009842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 395962009843 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 395962009844 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 395962009845 Probable Catalytic site; other site 395962009846 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 395962009847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395962009848 putative metal binding site [ion binding]; other site 395962009849 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 395962009850 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962009851 active site 395962009852 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 395962009853 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395962009854 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 395962009855 putative dimer interface [polypeptide binding]; other site 395962009856 N-terminal domain interface [polypeptide binding]; other site 395962009857 putative substrate binding pocket (H-site) [chemical binding]; other site 395962009858 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 395962009859 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 395962009860 Walker A/P-loop; other site 395962009861 ATP binding site [chemical binding]; other site 395962009862 Q-loop/lid; other site 395962009863 ABC transporter signature motif; other site 395962009864 Walker B; other site 395962009865 D-loop; other site 395962009866 H-loop/switch region; other site 395962009867 DevC protein; Region: devC; TIGR01185 395962009868 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 395962009869 FtsX-like permease family; Region: FtsX; cl15850 395962009870 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 395962009871 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962009872 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395962009873 Response regulator receiver domain; Region: Response_reg; pfam00072 395962009874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009875 active site 395962009876 phosphorylation site [posttranslational modification] 395962009877 intermolecular recognition site; other site 395962009878 dimerization interface [polypeptide binding]; other site 395962009879 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 395962009880 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 395962009881 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 395962009882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009883 active site 395962009884 phosphorylation site [posttranslational modification] 395962009885 intermolecular recognition site; other site 395962009886 dimerization interface [polypeptide binding]; other site 395962009887 CheB methylesterase; Region: CheB_methylest; pfam01339 395962009888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 395962009889 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 395962009890 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 395962009891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962009892 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 395962009893 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 395962009894 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 395962009895 P loop; other site 395962009896 GTP binding site [chemical binding]; other site 395962009897 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 395962009898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962009899 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 395962009900 substrate binding site [chemical binding]; other site 395962009901 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 395962009902 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009903 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009904 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009905 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009906 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009907 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009908 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962009909 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 395962009910 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962009911 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962009912 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 395962009913 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395962009914 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395962009915 Response regulator receiver domain; Region: Response_reg; pfam00072 395962009916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962009917 active site 395962009918 phosphorylation site [posttranslational modification] 395962009919 intermolecular recognition site; other site 395962009920 dimerization interface [polypeptide binding]; other site 395962009921 GAF domain; Region: GAF; cl15785 395962009922 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962009923 metal binding site [ion binding]; metal-binding site 395962009924 active site 395962009925 I-site; other site 395962009926 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 395962009927 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 395962009928 Walker A/P-loop; other site 395962009929 ATP binding site [chemical binding]; other site 395962009930 Q-loop/lid; other site 395962009931 ABC transporter signature motif; other site 395962009932 Walker B; other site 395962009933 D-loop; other site 395962009934 H-loop/switch region; other site 395962009935 Smr domain; Region: Smr; cl02619 395962009936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962009937 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 395962009938 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 395962009939 Predicted transcriptional regulators [Transcription]; Region: COG1725 395962009940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395962009941 DNA-binding site [nucleotide binding]; DNA binding site 395962009942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962009943 dimer interface [polypeptide binding]; other site 395962009944 conserved gate region; other site 395962009945 ABC-ATPase subunit interface; other site 395962009946 NMT1-like family; Region: NMT1_2; cl15260 395962009947 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 395962009948 META domain; Region: META; cl01245 395962009949 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 395962009950 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 395962009951 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 395962009952 C-terminal domain interface [polypeptide binding]; other site 395962009953 GSH binding site (G-site) [chemical binding]; other site 395962009954 dimer interface [polypeptide binding]; other site 395962009955 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 395962009956 dimer interface [polypeptide binding]; other site 395962009957 N-terminal domain interface [polypeptide binding]; other site 395962009958 substrate binding pocket (H-site) [chemical binding]; other site 395962009959 DoxX; Region: DoxX; cl00976 395962009960 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 395962009961 DNA primase; Validated; Region: dnaG; PRK05667 395962009962 CHC2 zinc finger; Region: zf-CHC2; cl15369 395962009963 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 395962009964 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 395962009965 active site 395962009966 metal binding site [ion binding]; metal-binding site 395962009967 interdomain interaction site; other site 395962009968 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 395962009969 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 395962009970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395962009971 DNA-binding site [nucleotide binding]; DNA binding site 395962009972 UTRA domain; Region: UTRA; cl01230 395962009973 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 395962009974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962009975 Walker A/P-loop; other site 395962009976 ATP binding site [chemical binding]; other site 395962009977 Q-loop/lid; other site 395962009978 ABC transporter signature motif; other site 395962009979 Walker B; other site 395962009980 D-loop; other site 395962009981 H-loop/switch region; other site 395962009982 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 395962009983 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 395962009984 Walker A/P-loop; other site 395962009985 ATP binding site [chemical binding]; other site 395962009986 Q-loop/lid; other site 395962009987 ABC transporter signature motif; other site 395962009988 Walker B; other site 395962009989 D-loop; other site 395962009990 H-loop/switch region; other site 395962009991 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 395962009992 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 395962009993 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 395962009994 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 395962009995 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 395962009996 DNA binding residues [nucleotide binding] 395962009997 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962009998 FOG: WD40 repeat [General function prediction only]; Region: COG2319 395962009999 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010000 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 395962010001 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 395962010002 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962010003 structural tetrad; other site 395962010004 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962010005 structural tetrad; other site 395962010006 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 395962010007 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 395962010008 homodimer interface [polypeptide binding]; other site 395962010009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962010010 catalytic residue [active] 395962010011 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 395962010012 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962010013 putative active site [active] 395962010014 Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958 395962010015 NodB motif; other site 395962010016 putative active site [active] 395962010017 putative catalytic site [active] 395962010018 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395962010019 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395962010020 HSP70 interaction site [polypeptide binding]; other site 395962010021 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 395962010022 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 395962010023 Rrf2 family protein; Region: rrf2_super; TIGR00738 395962010024 Helix-turn-helix domains; Region: HTH; cl00088 395962010025 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 395962010026 CobD/Cbib protein; Region: CobD_Cbib; cl00561 395962010027 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 395962010028 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 395962010029 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 395962010030 opcA protein; Region: OpcA; TIGR00534 395962010031 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 395962010032 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 395962010033 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 395962010034 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 395962010035 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 395962010036 Uncharacterized conserved protein [Function unknown]; Region: COG1565 395962010037 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 395962010038 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 395962010039 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 395962010040 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 395962010041 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 395962010042 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 395962010043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 395962010044 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 395962010045 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395962010046 active site 395962010047 metal binding site [ion binding]; metal-binding site 395962010048 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395962010049 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 395962010050 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 395962010051 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 395962010052 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 395962010053 Ligand Binding Site [chemical binding]; other site 395962010054 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 395962010055 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 395962010056 putative active site [active] 395962010057 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 395962010058 putative metal binding site; other site 395962010059 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 395962010060 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 395962010061 putative active site [active] 395962010062 TIGR03790 family protein; Region: TIGR03790 395962010063 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 395962010064 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 395962010065 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 395962010066 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395962010067 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 395962010068 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 395962010069 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 395962010070 putative active site [active] 395962010071 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 395962010072 putative active site [active] 395962010073 Cytochrome c; Region: Cytochrom_C; cl11414 395962010074 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962010075 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 395962010076 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 395962010077 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 395962010078 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 395962010079 RDD family; Region: RDD; cl00746 395962010080 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 395962010081 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 395962010082 putative active site cavity [active] 395962010083 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395962010084 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 395962010085 dimer interface [polypeptide binding]; other site 395962010086 active site 395962010087 metal binding site [ion binding]; metal-binding site 395962010088 glutathione binding site [chemical binding]; other site 395962010089 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 395962010090 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 395962010091 pheophytin binding site; other site 395962010092 chlorophyll binding site; other site 395962010093 quinone binding site; other site 395962010094 Fe binding site [ion binding]; other site 395962010095 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962010096 putative active site [active] 395962010097 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 395962010098 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 395962010099 G1 box; other site 395962010100 GTP/Mg2+ binding site [chemical binding]; other site 395962010101 G2 box; other site 395962010102 G3 box; other site 395962010103 Switch II region; other site 395962010104 G4 box; other site 395962010105 G5 box; other site 395962010106 tellurium resistance terB-like protein; Region: terB_like; cd07177 395962010107 metal binding site [ion binding]; metal-binding site 395962010108 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962010109 G1 box; other site 395962010110 GTP/Mg2+ binding site [chemical binding]; other site 395962010111 G2 box; other site 395962010112 Switch I region; other site 395962010113 G3 box; other site 395962010114 Switch II region; other site 395962010115 G4 box; other site 395962010116 G5 box; other site 395962010117 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 395962010118 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 395962010119 Protein export membrane protein; Region: SecD_SecF; cl14618 395962010120 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 395962010121 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395962010122 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395962010123 active site 395962010124 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 395962010125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962010126 dimer interface [polypeptide binding]; other site 395962010127 conserved gate region; other site 395962010128 putative PBP binding loops; other site 395962010129 ABC-ATPase subunit interface; other site 395962010130 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 395962010131 NMT1-like family; Region: NMT1_2; cl15260 395962010132 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 395962010133 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 395962010134 Walker A/P-loop; other site 395962010135 ATP binding site [chemical binding]; other site 395962010136 Q-loop/lid; other site 395962010137 ABC transporter signature motif; other site 395962010138 Walker B; other site 395962010139 D-loop; other site 395962010140 H-loop/switch region; other site 395962010141 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962010142 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010143 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010144 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010145 multifunctional aminopeptidase A; Provisional; Region: PRK00913 395962010146 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 395962010147 interface (dimer of trimers) [polypeptide binding]; other site 395962010148 Substrate-binding/catalytic site; other site 395962010149 Zn-binding sites [ion binding]; other site 395962010150 CHRD domain; Region: CHRD; cl06473 395962010151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962010152 S-adenosylmethionine binding site [chemical binding]; other site 395962010153 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962010154 structural tetrad; other site 395962010155 phage shock protein A; Region: phageshock_pspA; TIGR02977 395962010156 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395962010157 catalytic residues [active] 395962010158 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 395962010159 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395962010160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962010161 homodimer interface [polypeptide binding]; other site 395962010162 catalytic residue [active] 395962010163 Restriction endonuclease; Region: Mrr_cat; cl00516 395962010164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395962010165 non-specific DNA binding site [nucleotide binding]; other site 395962010166 salt bridge; other site 395962010167 sequence-specific DNA binding site [nucleotide binding]; other site 395962010168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010169 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962010170 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010171 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010172 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 395962010173 O-Antigen ligase; Region: Wzy_C; cl04850 395962010174 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395962010175 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 395962010176 putative NAD(P) binding site [chemical binding]; other site 395962010177 active site 395962010178 putative substrate binding site [chemical binding]; other site 395962010179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962010180 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962010181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395962010182 active site 395962010183 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 395962010184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010185 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 395962010186 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 395962010187 Walker A/P-loop; other site 395962010188 ATP binding site [chemical binding]; other site 395962010189 Q-loop/lid; other site 395962010190 ABC transporter signature motif; other site 395962010191 Walker B; other site 395962010192 D-loop; other site 395962010193 H-loop/switch region; other site 395962010194 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 395962010195 putative carbohydrate binding site [chemical binding]; other site 395962010196 ABC-2 type transporter; Region: ABC2_membrane; cl11417 395962010197 G8 domain; Region: G8; pfam10162 395962010198 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 395962010199 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 395962010200 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 395962010201 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 395962010202 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 395962010203 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 395962010204 Ligand binding site; other site 395962010205 Putative Catalytic site; other site 395962010206 DXD motif; other site 395962010207 GtrA-like protein; Region: GtrA; cl00971 395962010208 Acetokinase family; Region: Acetate_kinase; cl01029 395962010209 propionate/acetate kinase; Provisional; Region: PRK12379 395962010210 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 395962010211 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 395962010212 putative metal binding residues [ion binding]; other site 395962010213 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 395962010214 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 395962010215 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 395962010216 ABC-ATPase subunit interface; other site 395962010217 dimer interface [polypeptide binding]; other site 395962010218 putative PBP binding regions; other site 395962010219 Major royal jelly protein; Region: MRJP; pfam03022 395962010220 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 395962010221 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 395962010222 DNA binding residues [nucleotide binding] 395962010223 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 395962010224 catalytic residues [active] 395962010225 catalytic nucleophile [active] 395962010226 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962010227 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962010228 putative active site [active] 395962010229 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962010230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962010231 binding surface 395962010232 TPR motif; other site 395962010233 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 395962010234 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962010235 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 395962010236 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395962010237 inhibitor-cofactor binding pocket; inhibition site 395962010238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962010239 catalytic residue [active] 395962010240 Protein of unknown function (DUF497); Region: DUF497; cl01108 395962010241 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 395962010242 TROVE domain; Region: TROVE; pfam05731 395962010243 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 395962010244 metal ion-dependent adhesion site (MIDAS); other site 395962010245 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 395962010246 active site 395962010247 dimer interface [polypeptide binding]; other site 395962010248 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 395962010249 YokU-like protein; Region: YokU; cl15819 395962010250 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 395962010251 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 395962010252 dimer interface [polypeptide binding]; other site 395962010253 PYR/PP interface [polypeptide binding]; other site 395962010254 TPP binding site [chemical binding]; other site 395962010255 substrate binding site [chemical binding]; other site 395962010256 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 395962010257 Domain of unknown function; Region: EKR; cl11037 395962010258 4Fe-4S binding domain; Region: Fer4; cl02805 395962010259 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 395962010260 TPP-binding site [chemical binding]; other site 395962010261 dimer interface [polypeptide binding]; other site 395962010262 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962010263 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 395962010264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395962010265 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395962010266 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 395962010267 GIY-YIG motif/motif A; other site 395962010268 putative active site [active] 395962010269 putative metal binding site [ion binding]; other site 395962010270 Protein of unknown function (DUF497); Region: DUF497; cl01108 395962010271 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962010272 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 395962010273 catalytic residues [active] 395962010274 dimer interface [polypeptide binding]; other site 395962010275 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962010276 putative active site [active] 395962010277 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 395962010278 NADH(P)-binding; Region: NAD_binding_10; pfam13460 395962010279 NAD(P) binding site [chemical binding]; other site 395962010280 putative active site [active] 395962010281 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 395962010282 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 395962010283 active site 395962010284 ADP/pyrophosphate binding site [chemical binding]; other site 395962010285 dimerization interface [polypeptide binding]; other site 395962010286 allosteric effector site; other site 395962010287 fructose-1,6-bisphosphate binding site; other site 395962010288 phosphoribulokinase; Provisional; Region: PRK07429 395962010289 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 395962010290 active site 395962010291 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395962010292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962010293 active site 395962010294 phosphorylation site [posttranslational modification] 395962010295 intermolecular recognition site; other site 395962010296 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 395962010297 tetramer interface [polypeptide binding]; other site 395962010298 dimer interface [polypeptide binding]; other site 395962010299 circadian clock protein KaiC; Reviewed; Region: PRK09302 395962010300 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 395962010301 Walker A motif; other site 395962010302 ATP binding site [chemical binding]; other site 395962010303 Walker B motif; other site 395962010304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962010305 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962010306 Walker A motif; other site 395962010307 ATP binding site [chemical binding]; other site 395962010308 Walker B motif; other site 395962010309 HsdM N-terminal domain; Region: HsdM_N; pfam12161 395962010310 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 395962010311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010312 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 395962010313 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 395962010314 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395962010315 oligomeric interface; other site 395962010316 putative active site [active] 395962010317 homodimer interface [polypeptide binding]; other site 395962010318 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395962010319 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 395962010320 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395962010321 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395962010322 oligomeric interface; other site 395962010323 putative active site [active] 395962010324 homodimer interface [polypeptide binding]; other site 395962010325 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 395962010326 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 395962010327 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962010328 ATP binding site [chemical binding]; other site 395962010329 putative Mg++ binding site [ion binding]; other site 395962010330 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 395962010331 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 395962010332 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 395962010333 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 395962010334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962010335 Probable transposase; Region: OrfB_IS605; pfam01385 395962010336 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962010337 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 395962010338 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 395962010339 glutaminase active site [active] 395962010340 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 395962010341 dimer interface [polypeptide binding]; other site 395962010342 active site 395962010343 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 395962010344 dimer interface [polypeptide binding]; other site 395962010345 active site 395962010346 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 395962010347 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 395962010348 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 395962010349 Transposase domain (DUF772); Region: DUF772; cl15789 395962010350 Transposase; Region: HTH_Tnp_IS630; pfam01710 395962010351 Integrase core domain; Region: rve; cl01316 395962010352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010353 hypothetical protein; Provisional; Region: PRK06753 395962010354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395962010356 Helix-turn-helix domains; Region: HTH; cl00088 395962010357 FOG: CBS domain [General function prediction only]; Region: COG0517 395962010358 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 395962010359 TPR repeat; Region: TPR_11; pfam13414 395962010360 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962010361 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 395962010362 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 395962010363 active site 395962010364 catalytic residues [active] 395962010365 metal binding site [ion binding]; metal-binding site 395962010366 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 395962010367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010368 NAD(P) binding site [chemical binding]; other site 395962010369 active site 395962010370 hypothetical protein; Provisional; Region: PRK06847 395962010371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010372 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 395962010373 isocitrate dehydrogenase; Validated; Region: PRK07362 395962010374 AAA domain; Region: AAA_21; pfam13304 395962010375 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 395962010376 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 395962010377 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 395962010378 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 395962010379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962010380 Walker A/P-loop; other site 395962010381 ATP binding site [chemical binding]; other site 395962010382 Q-loop/lid; other site 395962010383 ABC transporter signature motif; other site 395962010384 Walker B; other site 395962010385 D-loop; other site 395962010386 H-loop/switch region; other site 395962010387 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 395962010388 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 395962010389 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 395962010390 active site 395962010391 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 395962010392 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395962010393 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395962010394 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 395962010395 Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205 395962010396 DsrE/DsrF-like family; Region: DrsE; cl00672 395962010397 DsrE/DsrF-like family; Region: DrsE; cl00672 395962010398 DsrE/DsrF-like family; Region: DrsE; cl00672 395962010399 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395962010400 Ligand Binding Site [chemical binding]; other site 395962010401 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962010402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962010403 active site 395962010404 phosphorylation site [posttranslational modification] 395962010405 intermolecular recognition site; other site 395962010406 dimerization interface [polypeptide binding]; other site 395962010407 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962010408 DNA binding site [nucleotide binding] 395962010409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 395962010410 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 395962010411 Uncharacterized conserved protein [Function unknown]; Region: COG1432 395962010412 LabA_like proteins; Region: LabA; cd10911 395962010413 putative metal binding site [ion binding]; other site 395962010414 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 395962010415 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 395962010416 active site 395962010417 HIGH motif; other site 395962010418 KMSKS motif; other site 395962010419 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 395962010420 tRNA binding surface [nucleotide binding]; other site 395962010421 anticodon binding site; other site 395962010422 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395962010423 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962010424 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 395962010425 active site 395962010426 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 395962010427 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 395962010428 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962010429 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 395962010430 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 395962010431 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 395962010432 ligand-binding site [chemical binding]; other site 395962010433 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 395962010434 Leucine-rich repeats; other site 395962010435 Leucine rich repeat; Region: LRR_8; pfam13855 395962010436 Substrate binding site [chemical binding]; other site 395962010437 Leucine rich repeat; Region: LRR_8; pfam13855 395962010438 Leucine rich repeat; Region: LRR_8; pfam13855 395962010439 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 395962010440 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962010441 G1 box; other site 395962010442 GTP/Mg2+ binding site [chemical binding]; other site 395962010443 G2 box; other site 395962010444 Switch I region; other site 395962010445 G3 box; other site 395962010446 Switch II region; other site 395962010447 G4 box; other site 395962010448 G5 box; other site 395962010449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962010450 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 395962010451 active site 395962010452 motif I; other site 395962010453 motif II; other site 395962010454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962010455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962010456 S-adenosylmethionine binding site [chemical binding]; other site 395962010457 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 395962010458 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 395962010459 FtsX-like permease family; Region: FtsX; cl15850 395962010460 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 395962010461 glutathione synthetase; Provisional; Region: PRK05246 395962010462 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 395962010463 ATP-grasp domain; Region: ATP-grasp_4; cl03087 395962010464 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 395962010465 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 395962010466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 395962010467 cell division protein ZipA; Provisional; Region: PRK03427 395962010468 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 395962010469 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 395962010470 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 395962010471 active site 395962010472 hydrophilic channel; other site 395962010473 dimerization interface [polypeptide binding]; other site 395962010474 catalytic residues [active] 395962010475 active site lid [active] 395962010476 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 395962010477 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395962010478 putative binding surface; other site 395962010479 active site 395962010480 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 395962010481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962010482 ATP binding site [chemical binding]; other site 395962010483 Mg2+ binding site [ion binding]; other site 395962010484 G-X-G motif; other site 395962010485 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962010486 Response regulator receiver domain; Region: Response_reg; pfam00072 395962010487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962010488 active site 395962010489 phosphorylation site [posttranslational modification] 395962010490 intermolecular recognition site; other site 395962010491 dimerization interface [polypeptide binding]; other site 395962010492 GAF domain; Region: GAF_2; pfam13185 395962010493 GAF domain; Region: GAF; cl15785 395962010494 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962010495 GAF domain; Region: GAF; cl15785 395962010496 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962010497 GAF domain; Region: GAF; cl15785 395962010498 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962010499 GAF domain; Region: GAF; cl15785 395962010500 GAF domain; Region: GAF_2; pfam13185 395962010501 GAF domain; Region: GAF; cl15785 395962010502 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962010503 GAF domain; Region: GAF; cl15785 395962010504 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395962010505 GAF domain; Region: GAF; cl15785 395962010506 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395962010507 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395962010508 dimer interface [polypeptide binding]; other site 395962010509 putative CheW interface [polypeptide binding]; other site 395962010510 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962010511 Response regulator receiver domain; Region: Response_reg; pfam00072 395962010512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962010513 active site 395962010514 phosphorylation site [posttranslational modification] 395962010515 intermolecular recognition site; other site 395962010516 dimerization interface [polypeptide binding]; other site 395962010517 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 395962010518 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 395962010519 homotetramer interface [polypeptide binding]; other site 395962010520 FMN binding site [chemical binding]; other site 395962010521 homodimer contacts [polypeptide binding]; other site 395962010522 putative active site [active] 395962010523 putative substrate binding site [chemical binding]; other site 395962010524 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395962010525 Ligand Binding Site [chemical binding]; other site 395962010526 PhoD-like phosphatase; Region: PhoD; pfam09423 395962010527 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 395962010528 putative active site [active] 395962010529 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395962010530 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 395962010531 putative dimer interface [polypeptide binding]; other site 395962010532 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 395962010533 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 395962010534 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 395962010535 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 395962010536 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 395962010537 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 395962010538 MoaE interaction surface [polypeptide binding]; other site 395962010539 thiocarboxylated glycine; other site 395962010540 threonine synthase; Validated; Region: PRK07591 395962010541 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 395962010542 homodimer interface [polypeptide binding]; other site 395962010543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962010544 catalytic residue [active] 395962010545 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962010546 putative active site [active] 395962010547 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 395962010548 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 395962010549 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 395962010550 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395962010551 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962010552 active site 395962010553 ATP binding site [chemical binding]; other site 395962010554 substrate binding site [chemical binding]; other site 395962010555 activation loop (A-loop); other site 395962010556 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 395962010557 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 395962010558 acyl-CoA synthetase; Validated; Region: PRK05850 395962010559 AMP-binding enzyme; Region: AMP-binding; cl15778 395962010560 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 395962010561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395962010562 motif II; other site 395962010563 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 395962010564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010565 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 395962010566 active site 395962010567 substrate-binding site [chemical binding]; other site 395962010568 metal-binding site [ion binding] 395962010569 ATP binding site [chemical binding]; other site 395962010570 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395962010571 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 395962010572 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395962010573 catalytic residue [active] 395962010574 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395962010575 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 395962010576 StbA protein; Region: StbA; pfam06406 395962010577 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 395962010578 Fe-S cluster binding site [ion binding]; other site 395962010579 active site 395962010580 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395962010581 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 395962010582 Walker A/P-loop; other site 395962010583 ATP binding site [chemical binding]; other site 395962010584 Q-loop/lid; other site 395962010585 ABC transporter signature motif; other site 395962010586 Walker B; other site 395962010587 D-loop; other site 395962010588 H-loop/switch region; other site 395962010589 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 395962010590 Transposase domain (DUF772); Region: DUF772; cl15789 395962010591 Transposase domain (DUF772); Region: DUF772; cl15789 395962010592 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 395962010593 putative hexamer interface [polypeptide binding]; other site 395962010594 putative hexagonal pore; other site 395962010595 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 395962010596 Hexamer interface [polypeptide binding]; other site 395962010597 Hexagonal pore residue; other site 395962010598 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 395962010599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010600 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 395962010601 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 395962010602 Cation transport protein; Region: TrkH; cl10514 395962010603 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395962010604 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 395962010605 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 395962010606 G-X-X-G motif; other site 395962010607 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 395962010608 RxxxH motif; other site 395962010609 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 395962010610 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 395962010611 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 395962010612 Bacterial PH domain; Region: DUF304; cl01348 395962010613 Ribonuclease P; Region: Ribonuclease_P; cl00457 395962010614 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 395962010615 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 395962010616 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 395962010617 ligand binding site; other site 395962010618 oligomer interface; other site 395962010619 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 395962010620 dimer interface [polypeptide binding]; other site 395962010621 N-terminal domain interface [polypeptide binding]; other site 395962010622 sulfate 1 binding site; other site 395962010623 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 395962010624 S-layer homology domain; Region: SLH; pfam00395 395962010625 S-layer homology domain; Region: SLH; pfam00395 395962010626 Ferritin-like domain; Region: Ferritin; pfam00210 395962010627 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 395962010628 dimerization interface [polypeptide binding]; other site 395962010629 DPS ferroxidase diiron center [ion binding]; other site 395962010630 ion pore; other site 395962010631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962010632 Permease; Region: Permease; cl00510 395962010633 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 395962010634 Domain of unknown function DUF59; Region: DUF59; cl00941 395962010635 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 395962010636 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 395962010637 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 395962010638 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395962010639 putative binding surface; other site 395962010640 active site 395962010641 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 395962010642 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 395962010643 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 395962010644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962010645 FeS/SAM binding site; other site 395962010646 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 395962010647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010648 Methyltransferase domain; Region: Methyltransf_31; pfam13847 395962010649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962010650 S-adenosylmethionine binding site [chemical binding]; other site 395962010651 GUN4-like; Region: GUN4; pfam05419 395962010652 conserved hypothetical protein; Region: TIGR03492 395962010653 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 395962010654 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 395962010655 RimM N-terminal domain; Region: RimM; pfam01782 395962010656 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 395962010657 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 395962010658 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 395962010659 ATP adenylyltransferase; Region: ATP_transf; pfam09830 395962010660 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 395962010661 magnesium chelatase subunit H; Provisional; Region: PLN03241 395962010662 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 395962010663 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 395962010664 TRAM domain; Region: TRAM; cl01282 395962010665 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 395962010666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962010667 S-adenosylmethionine binding site [chemical binding]; other site 395962010668 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 395962010669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 395962010670 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 395962010671 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 395962010672 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 395962010673 GTP/Mg2+ binding site [chemical binding]; other site 395962010674 G4 box; other site 395962010675 G5 box; other site 395962010676 G1 box; other site 395962010677 Switch I region; other site 395962010678 G2 box; other site 395962010679 G3 box; other site 395962010680 Switch II region; other site 395962010681 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037 395962010682 ligand binding surface [chemical binding]; other site 395962010683 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 395962010684 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 395962010685 Competence protein; Region: Competence; cl00471 395962010686 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395962010687 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 395962010688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962010689 dimer interface [polypeptide binding]; other site 395962010690 phosphorylation site [posttranslational modification] 395962010691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962010692 ATP binding site [chemical binding]; other site 395962010693 Mg2+ binding site [ion binding]; other site 395962010694 G-X-G motif; other site 395962010695 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 395962010696 Creatinine amidohydrolase; Region: Creatininase; cl00618 395962010697 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 395962010698 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 395962010699 Putative esterase; Region: Esterase; pfam00756 395962010700 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962010701 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962010702 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 395962010703 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 395962010704 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 395962010705 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 395962010706 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 395962010707 Domain of unknown function DUF21; Region: DUF21; pfam01595 395962010708 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 395962010709 Transporter associated domain; Region: CorC_HlyC; cl08393 395962010710 Chromate transporter; Region: Chromate_transp; pfam02417 395962010711 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 395962010712 Chromate transporter; Region: Chromate_transp; pfam02417 395962010713 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 395962010714 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 395962010715 ThiS interaction site; other site 395962010716 putative active site [active] 395962010717 tetramer interface [polypeptide binding]; other site 395962010718 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 395962010719 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 395962010720 putative C-terminal domain interface [polypeptide binding]; other site 395962010721 putative GSH binding site (G-site) [chemical binding]; other site 395962010722 putative dimer interface [polypeptide binding]; other site 395962010723 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 395962010724 dimer interface [polypeptide binding]; other site 395962010725 N-terminal domain interface [polypeptide binding]; other site 395962010726 substrate binding pocket (H-site) [chemical binding]; other site 395962010727 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 395962010728 GAF domain; Region: GAF; cl15785 395962010729 Phytochrome region; Region: PHY; pfam00360 395962010730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962010731 dimer interface [polypeptide binding]; other site 395962010732 phosphorylation site [posttranslational modification] 395962010733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962010734 ATP binding site [chemical binding]; other site 395962010735 Mg2+ binding site [ion binding]; other site 395962010736 G-X-G motif; other site 395962010737 Response regulator receiver domain; Region: Response_reg; pfam00072 395962010738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962010739 active site 395962010740 phosphorylation site [posttranslational modification] 395962010741 intermolecular recognition site; other site 395962010742 dimerization interface [polypeptide binding]; other site 395962010743 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 395962010744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962010745 Family description; Region: UvrD_C_2; cl15862 395962010746 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395962010747 catalytic residues [active] 395962010748 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 395962010749 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 395962010750 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 395962010751 active site 395962010752 homodimer interface [polypeptide binding]; other site 395962010753 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 395962010754 replicative DNA helicase; Region: DnaB; TIGR00665 395962010755 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 395962010756 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 395962010757 Walker A motif; other site 395962010758 ATP binding site [chemical binding]; other site 395962010759 Walker B motif; other site 395962010760 DNA binding loops [nucleotide binding] 395962010761 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 395962010762 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962010763 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 395962010764 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 395962010765 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 395962010766 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010767 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010768 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010769 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010770 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 395962010771 active site clefts [active] 395962010772 zinc binding site [ion binding]; other site 395962010773 dimer interface [polypeptide binding]; other site 395962010774 Probable transposase; Region: OrfB_IS605; pfam01385 395962010775 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962010776 rod shape-determining protein MreD; Region: MreD; cl01087 395962010777 rod shape-determining protein MreC; Region: MreC; pfam04085 395962010778 rod shape-determining protein MreB; Provisional; Region: PRK13927 395962010779 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 395962010780 dimer interface [polypeptide binding]; other site 395962010781 ssDNA binding site [nucleotide binding]; other site 395962010782 tetramer (dimer of dimers) interface [polypeptide binding]; other site 395962010783 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 395962010784 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 395962010785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395962010786 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 395962010787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395962010788 DNA binding residues [nucleotide binding] 395962010789 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 395962010790 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962010791 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 395962010792 metal binding site 2 [ion binding]; metal-binding site 395962010793 putative DNA binding helix; other site 395962010794 metal binding site 1 [ion binding]; metal-binding site 395962010795 dimer interface [polypeptide binding]; other site 395962010796 structural Zn2+ binding site [ion binding]; other site 395962010797 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 395962010798 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 395962010799 putative active site [active] 395962010800 catalytic triad [active] 395962010801 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 395962010802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010803 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 395962010804 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395962010805 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395962010806 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395962010807 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395962010808 DNA binding residues [nucleotide binding] 395962010809 dimerization interface [polypeptide binding]; other site 395962010810 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 395962010811 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 395962010812 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 395962010813 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 395962010814 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 395962010815 NAD binding site [chemical binding]; other site 395962010816 homodimer interface [polypeptide binding]; other site 395962010817 active site 395962010818 substrate binding site [chemical binding]; other site 395962010819 PsbJ; Region: PsbJ; cl09469 395962010820 PsbL protein; Region: PsbL; cl03581 395962010821 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 395962010822 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 395962010823 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 395962010824 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 395962010825 Ycf48-like protein; Provisional; Region: PRK13684 395962010826 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 395962010827 Rubredoxin; Region: Rubredoxin; pfam00301 395962010828 iron binding site [ion binding]; other site 395962010829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395962010830 Helix-turn-helix domains; Region: HTH; cl00088 395962010831 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 395962010832 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 395962010833 tetramer interface [polypeptide binding]; other site 395962010834 TPP-binding site [chemical binding]; other site 395962010835 heterodimer interface [polypeptide binding]; other site 395962010836 phosphorylation loop region [posttranslational modification] 395962010837 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 395962010838 StbA protein; Region: StbA; pfam06406 395962010839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962010840 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962010841 Probable transposase; Region: OrfB_IS605; pfam01385 395962010842 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962010843 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 395962010844 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395962010845 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010846 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395962010847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395962010848 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 395962010849 GSH binding site [chemical binding]; other site 395962010850 catalytic residues [active] 395962010851 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 395962010852 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 395962010853 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 395962010854 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 395962010855 active site 395962010856 catalytic site [active] 395962010857 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 395962010858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962010859 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 395962010860 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 395962010861 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 395962010862 trmE is a tRNA modification GTPase; Region: trmE; cd04164 395962010863 G1 box; other site 395962010864 GTP/Mg2+ binding site [chemical binding]; other site 395962010865 Switch I region; other site 395962010866 G2 box; other site 395962010867 Switch II region; other site 395962010868 G3 box; other site 395962010869 G4 box; other site 395962010870 G5 box; other site 395962010871 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 395962010872 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 395962010873 HicB family; Region: HicB; pfam05534 395962010874 acetolactate synthase; Reviewed; Region: PRK08322 395962010875 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395962010876 PYR/PP interface [polypeptide binding]; other site 395962010877 dimer interface [polypeptide binding]; other site 395962010878 TPP binding site [chemical binding]; other site 395962010879 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 395962010880 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 395962010881 TPP-binding site [chemical binding]; other site 395962010882 dimer interface [polypeptide binding]; other site 395962010883 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395962010884 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 395962010885 NAD(P) binding site [chemical binding]; other site 395962010886 catalytic residues [active] 395962010887 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 395962010888 Secretin and TonB N terminus short domain; Region: STN; cl06624 395962010889 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 395962010890 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 395962010891 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 395962010892 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 395962010893 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 395962010894 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395962010895 Protein kinase domain; Region: Pkinase; pfam00069 395962010896 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395962010897 active site 395962010898 ATP binding site [chemical binding]; other site 395962010899 substrate binding site [chemical binding]; other site 395962010900 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962010901 substrate binding site [chemical binding]; other site 395962010902 activation loop (A-loop); other site 395962010903 activation loop (A-loop); other site 395962010904 amidophosphoribosyltransferase; Provisional; Region: PRK07349 395962010905 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 395962010906 active site 395962010907 tetramer interface [polypeptide binding]; other site 395962010908 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962010909 active site 395962010910 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 395962010911 DNA polymerase III subunit delta; Validated; Region: PRK07452 395962010912 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 395962010913 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 395962010914 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 395962010915 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 395962010916 active site 395962010917 dimer interface [polypeptide binding]; other site 395962010918 metal binding site [ion binding]; metal-binding site 395962010919 S-layer homology domain; Region: SLH; pfam00395 395962010920 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 395962010921 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 395962010922 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395962010923 Ligand Binding Site [chemical binding]; other site 395962010924 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 395962010925 MoaE interaction surface [polypeptide binding]; other site 395962010926 MoeB interaction surface [polypeptide binding]; other site 395962010927 thiocarboxylated glycine; other site 395962010928 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 395962010929 NADPH bind site [chemical binding]; other site 395962010930 putative FMN binding site [chemical binding]; other site 395962010931 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 395962010932 putative FMN binding site [chemical binding]; other site 395962010933 NADPH bind site [chemical binding]; other site 395962010934 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395962010935 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 395962010936 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 395962010937 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962010938 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 395962010939 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 395962010940 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 395962010941 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 395962010942 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 395962010943 Protein of unknown function (DUF1626); Region: DUF1626; pfam07788 395962010944 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 395962010945 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 395962010946 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 395962010947 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 395962010948 Phytase; Region: Phytase; pfam02333 395962010949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962010950 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962010951 Probable transposase; Region: OrfB_IS605; pfam01385 395962010952 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962010953 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 395962010954 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 395962010955 G1 box; other site 395962010956 putative GEF interaction site [polypeptide binding]; other site 395962010957 GTP/Mg2+ binding site [chemical binding]; other site 395962010958 Switch I region; other site 395962010959 G2 box; other site 395962010960 G3 box; other site 395962010961 Switch II region; other site 395962010962 G4 box; other site 395962010963 G5 box; other site 395962010964 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 395962010965 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 395962010966 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 395962010967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 395962010968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962010969 Coenzyme A binding pocket [chemical binding]; other site 395962010970 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 395962010971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962010972 G1 box; other site 395962010973 GTP/Mg2+ binding site [chemical binding]; other site 395962010974 G2 box; other site 395962010975 Switch I region; other site 395962010976 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962010977 G3 box; other site 395962010978 Switch II region; other site 395962010979 GTP/Mg2+ binding site [chemical binding]; other site 395962010980 G4 box; other site 395962010981 G5 box; other site 395962010982 KGK domain; Region: KGK; pfam08872 395962010983 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395962010984 active site 395962010985 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 395962010986 putative acyl-acceptor binding pocket; other site 395962010987 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962010988 putative active site [active] 395962010989 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 395962010990 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395962010991 phosphopeptide binding site; other site 395962010992 cyclase homology domain; Region: CHD; cd07302 395962010993 nucleotidyl binding site; other site 395962010994 metal binding site [ion binding]; metal-binding site 395962010995 dimer interface [polypeptide binding]; other site 395962010996 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 395962010997 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 395962010998 active site 395962010999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962011000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395962011001 non-specific DNA binding site [nucleotide binding]; other site 395962011002 salt bridge; other site 395962011003 sequence-specific DNA binding site [nucleotide binding]; other site 395962011004 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 395962011005 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 395962011006 dimerization interface [polypeptide binding]; other site 395962011007 active site 395962011008 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 395962011009 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 395962011010 dimer interface [polypeptide binding]; other site 395962011011 decamer (pentamer of dimers) interface [polypeptide binding]; other site 395962011012 catalytic triad [active] 395962011013 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 395962011014 Family of unknown function (DUF490); Region: DUF490; pfam04357 395962011015 O-Antigen ligase; Region: Wzy_C; cl04850 395962011016 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 395962011017 active site 395962011018 intersubunit interactions; other site 395962011019 catalytic residue [active] 395962011020 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395962011021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962011022 active site 395962011023 phosphorylation site [posttranslational modification] 395962011024 intermolecular recognition site; other site 395962011025 dimerization interface [polypeptide binding]; other site 395962011026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395962011027 DNA binding site [nucleotide binding] 395962011028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962011029 dimer interface [polypeptide binding]; other site 395962011030 phosphorylation site [posttranslational modification] 395962011031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962011032 ATP binding site [chemical binding]; other site 395962011033 Mg2+ binding site [ion binding]; other site 395962011034 G-X-G motif; other site 395962011035 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 395962011036 DNA binding site [nucleotide binding] 395962011037 Int/Topo IB signature motif; other site 395962011038 active site 395962011039 catalytic residues [active] 395962011040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395962011041 non-specific DNA binding site [nucleotide binding]; other site 395962011042 salt bridge; other site 395962011043 sequence-specific DNA binding site [nucleotide binding]; other site 395962011044 Transposase; Region: DEDD_Tnp_IS110; pfam01548 395962011045 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 395962011046 O-Antigen ligase; Region: Wzy_C; cl04850 395962011047 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 395962011048 Tubulin like; Region: Tubulin_2; pfam13809 395962011049 Short C-terminal domain; Region: SHOCT; cl01373 395962011050 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 395962011051 ligand binding site [chemical binding]; other site 395962011052 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 395962011053 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 395962011054 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 395962011055 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 395962011056 FAD binding pocket [chemical binding]; other site 395962011057 FAD binding motif [chemical binding]; other site 395962011058 phosphate binding motif [ion binding]; other site 395962011059 beta-alpha-beta structure motif; other site 395962011060 NAD binding pocket [chemical binding]; other site 395962011061 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395962011062 catalytic loop [active] 395962011063 iron binding site [ion binding]; other site 395962011064 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 395962011065 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 395962011066 Walker A motif; other site 395962011067 ATP binding site [chemical binding]; other site 395962011068 Walker B motif; other site 395962011069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962011070 ATP binding site [chemical binding]; other site 395962011071 Walker B motif; other site 395962011072 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 395962011073 tetramer interface [polypeptide binding]; other site 395962011074 dimer interface [polypeptide binding]; other site 395962011075 KaiA domain; Region: KaiA; pfam07688 395962011076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 395962011077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962011078 dimer interface [polypeptide binding]; other site 395962011079 phosphorylation site [posttranslational modification] 395962011080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962011081 ATP binding site [chemical binding]; other site 395962011082 Mg2+ binding site [ion binding]; other site 395962011083 G-X-G motif; other site 395962011084 Response regulator receiver domain; Region: Response_reg; pfam00072 395962011085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962011086 active site 395962011087 phosphorylation site [posttranslational modification] 395962011088 intermolecular recognition site; other site 395962011089 dimerization interface [polypeptide binding]; other site 395962011090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962011091 dimer interface [polypeptide binding]; other site 395962011092 conserved gate region; other site 395962011093 putative PBP binding loops; other site 395962011094 ABC-ATPase subunit interface; other site 395962011095 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 395962011096 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395962011097 active site 395962011098 metal binding site [ion binding]; metal-binding site 395962011099 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 395962011100 active site 395962011101 TPR repeat; Region: TPR_11; pfam13414 395962011102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962011103 binding surface 395962011104 TPR motif; other site 395962011105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962011106 binding surface 395962011107 TPR repeat; Region: TPR_11; pfam13414 395962011108 TPR motif; other site 395962011109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962011110 binding surface 395962011111 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395962011112 TPR motif; other site 395962011113 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 395962011114 putative catalytic residue [active] 395962011115 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 395962011116 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 395962011117 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 395962011118 DXD motif; other site 395962011119 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 395962011120 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 395962011121 LabA_like proteins; Region: LabA_like; cd06167 395962011122 putative metal binding site [ion binding]; other site 395962011123 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 395962011124 DNA-binding site [nucleotide binding]; DNA binding site 395962011125 RNA-binding motif; other site 395962011126 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 395962011127 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962011128 Cupin domain; Region: Cupin_2; cl09118 395962011129 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 395962011130 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 395962011131 carbonic anhydrase; Provisional; Region: PRK15219 395962011132 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 395962011133 active site clefts [active] 395962011134 zinc binding site [ion binding]; other site 395962011135 dimer interface [polypeptide binding]; other site 395962011136 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 395962011137 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 395962011138 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 395962011139 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 395962011140 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 395962011141 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395962011142 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 395962011143 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 395962011144 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 395962011145 cell division protein FtsZ; Validated; Region: PRK09330 395962011146 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 395962011147 nucleotide binding site [chemical binding]; other site 395962011148 SulA interaction site; other site 395962011149 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 395962011150 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 395962011151 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 395962011152 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 395962011153 C-terminal peptidase (prc); Region: prc; TIGR00225 395962011154 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 395962011155 protein binding site [polypeptide binding]; other site 395962011156 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 395962011157 Catalytic dyad [active] 395962011158 Ferritin-like domain; Region: Ferritin; pfam00210 395962011159 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 395962011160 dinuclear metal binding motif [ion binding]; other site 395962011161 Iron permease FTR1 family; Region: FTR1; cl00475 395962011162 EVE domain; Region: EVE; cl00728 395962011163 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 395962011164 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 395962011165 tetramer (dimer of dimers) interface [polypeptide binding]; other site 395962011166 active site 395962011167 dimer interface [polypeptide binding]; other site 395962011168 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 395962011169 RNA/DNA binding site [nucleotide binding]; other site 395962011170 RRM dimerization site [polypeptide binding]; other site 395962011171 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 395962011172 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 395962011173 NAD(P) binding site [chemical binding]; other site 395962011174 homotetramer interface [polypeptide binding]; other site 395962011175 homodimer interface [polypeptide binding]; other site 395962011176 active site 395962011177 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 395962011178 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 395962011179 Walker A/P-loop; other site 395962011180 ATP binding site [chemical binding]; other site 395962011181 Q-loop/lid; other site 395962011182 ABC transporter signature motif; other site 395962011183 Walker B; other site 395962011184 D-loop; other site 395962011185 H-loop/switch region; other site 395962011186 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 395962011187 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 395962011188 Walker A/P-loop; other site 395962011189 ATP binding site [chemical binding]; other site 395962011190 Q-loop/lid; other site 395962011191 ABC transporter signature motif; other site 395962011192 Walker B; other site 395962011193 D-loop; other site 395962011194 H-loop/switch region; other site 395962011195 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 395962011196 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 395962011197 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 395962011198 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 395962011199 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962011200 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 395962011201 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 395962011202 putative ADP-binding pocket [chemical binding]; other site 395962011203 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962011204 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962011205 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 395962011206 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 395962011207 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962011208 Walker A/P-loop; other site 395962011209 ATP binding site [chemical binding]; other site 395962011210 Q-loop/lid; other site 395962011211 ABC transporter signature motif; other site 395962011212 Walker B; other site 395962011213 D-loop; other site 395962011214 H-loop/switch region; other site 395962011215 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395962011216 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395962011217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395962011218 ligand binding site [chemical binding]; other site 395962011219 flexible hinge region; other site 395962011220 Helix-turn-helix domains; Region: HTH; cl00088 395962011221 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 395962011222 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 395962011223 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962011224 FeS/SAM binding site; other site 395962011225 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 395962011226 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 395962011227 ATP binding site [chemical binding]; other site 395962011228 Mg++ binding site [ion binding]; other site 395962011229 motif III; other site 395962011230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395962011231 nucleotide binding region [chemical binding]; other site 395962011232 ATP-binding site [chemical binding]; other site 395962011233 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 395962011234 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 395962011235 active site residue [active] 395962011236 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 395962011237 active site residue [active] 395962011238 putative inner membrane protein; Provisional; Region: PRK11099 395962011239 Sulphur transport; Region: Sulf_transp; cl01018 395962011240 putative inner membrane protein; Provisional; Region: PRK11099 395962011241 Sulphur transport; Region: Sulf_transp; cl01018 395962011242 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 395962011243 classical (c) SDRs; Region: SDR_c; cd05233 395962011244 NAD(P) binding site [chemical binding]; other site 395962011245 active site 395962011246 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 395962011247 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962011248 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 395962011249 Response regulator receiver domain; Region: Response_reg; pfam00072 395962011250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962011251 active site 395962011252 phosphorylation site [posttranslational modification] 395962011253 intermolecular recognition site; other site 395962011254 dimerization interface [polypeptide binding]; other site 395962011255 Response regulator receiver domain; Region: Response_reg; pfam00072 395962011256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962011257 active site 395962011258 phosphorylation site [posttranslational modification] 395962011259 intermolecular recognition site; other site 395962011260 dimerization interface [polypeptide binding]; other site 395962011261 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962011262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395962011263 dimerization interface [polypeptide binding]; other site 395962011264 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395962011265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395962011266 dimer interface [polypeptide binding]; other site 395962011267 putative CheW interface [polypeptide binding]; other site 395962011268 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 395962011269 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395962011270 putative binding surface; other site 395962011271 active site 395962011272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962011273 ATP binding site [chemical binding]; other site 395962011274 Mg2+ binding site [ion binding]; other site 395962011275 G-X-G motif; other site 395962011276 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395962011277 Response regulator receiver domain; Region: Response_reg; pfam00072 395962011278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962011279 active site 395962011280 phosphorylation site [posttranslational modification] 395962011281 intermolecular recognition site; other site 395962011282 dimerization interface [polypeptide binding]; other site 395962011283 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 395962011284 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962011285 putative active site [active] 395962011286 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 395962011287 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 395962011288 active site 395962011289 substrate binding site [chemical binding]; other site 395962011290 trimer interface [polypeptide binding]; other site 395962011291 CoA binding site [chemical binding]; other site 395962011292 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 395962011293 substrate binding site; other site 395962011294 dimer interface; other site 395962011295 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 395962011296 cofactor binding site; other site 395962011297 DNA binding site [nucleotide binding] 395962011298 substrate interaction site [chemical binding]; other site 395962011299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 395962011300 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 395962011301 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395962011302 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 395962011303 active site 395962011304 metal binding site [ion binding]; metal-binding site 395962011305 ATP cone domain; Region: ATP-cone; pfam03477 395962011306 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 395962011307 Class I ribonucleotide reductase; Region: RNR_I; cd01679 395962011308 active site 395962011309 dimer interface [polypeptide binding]; other site 395962011310 catalytic residues [active] 395962011311 effector binding site; other site 395962011312 R2 peptide binding site; other site 395962011313 Domain of unknown function DUF29; Region: DUF29; pfam01724 395962011314 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 395962011315 dimer interface [polypeptide binding]; other site 395962011316 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 395962011317 putative radical transfer pathway; other site 395962011318 diiron center [ion binding]; other site 395962011319 tyrosyl radical; other site 395962011320 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 395962011321 homodimer interface [polypeptide binding]; other site 395962011322 substrate-cofactor binding pocket; other site 395962011323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395962011324 catalytic residue [active] 395962011325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395962011326 BT1 family; Region: BT1; pfam03092 395962011327 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395962011328 active site 395962011329 NTP binding site [chemical binding]; other site 395962011330 metal binding triad [ion binding]; metal-binding site 395962011331 antibiotic binding site [chemical binding]; other site 395962011332 Cytochrome c; Region: Cytochrom_C; cl11414 395962011333 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 395962011334 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 395962011335 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 395962011336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962011337 ATP binding site [chemical binding]; other site 395962011338 putative Mg++ binding site [ion binding]; other site 395962011339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395962011340 nucleotide binding region [chemical binding]; other site 395962011341 ATP-binding site [chemical binding]; other site 395962011342 TRCF domain; Region: TRCF; cl04088 395962011343 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 395962011344 Protein of unknown function (DUF433); Region: DUF433; cl01030 395962011345 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962011346 YcfA-like protein; Region: YcfA; cl00752 395962011347 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962011348 magnesium chelatase subunit H; Provisional; Region: PRK12493 395962011349 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 395962011350 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 395962011351 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962011352 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 395962011353 putative active site [active] 395962011354 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 395962011355 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 395962011356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395962011357 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 395962011358 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395962011359 DNA binding residues [nucleotide binding] 395962011360 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 395962011361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962011362 dimer interface [polypeptide binding]; other site 395962011363 conserved gate region; other site 395962011364 putative PBP binding loops; other site 395962011365 ABC-ATPase subunit interface; other site 395962011366 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 395962011367 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395962011368 active site 395962011369 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 395962011370 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 395962011371 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395962011372 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962011373 putative active site [active] 395962011374 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 395962011375 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 395962011376 active site 395962011377 intersubunit interface [polypeptide binding]; other site 395962011378 catalytic residue [active] 395962011379 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 395962011380 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 395962011381 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 395962011382 TIR domain; Region: TIR_2; cl15770 395962011383 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962011384 putative active site [active] 395962011385 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 395962011386 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 395962011387 active site 395962011388 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395962011389 active site 395962011390 NTP binding site [chemical binding]; other site 395962011391 metal binding triad [ion binding]; metal-binding site 395962011392 antibiotic binding site [chemical binding]; other site 395962011393 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 395962011394 GAF domain; Region: GAF_2; pfam13185 395962011395 GAF domain; Region: GAF; cl15785 395962011396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962011397 dimer interface [polypeptide binding]; other site 395962011398 phosphorylation site [posttranslational modification] 395962011399 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 395962011400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962011401 ATP binding site [chemical binding]; other site 395962011402 Mg2+ binding site [ion binding]; other site 395962011403 G-X-G motif; other site 395962011404 Response regulator receiver domain; Region: Response_reg; pfam00072 395962011405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962011406 active site 395962011407 phosphorylation site [posttranslational modification] 395962011408 intermolecular recognition site; other site 395962011409 dimerization interface [polypeptide binding]; other site 395962011410 PAS fold; Region: PAS_4; pfam08448 395962011411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962011412 putative active site [active] 395962011413 heme pocket [chemical binding]; other site 395962011414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962011415 PAS fold; Region: PAS_3; pfam08447 395962011416 putative active site [active] 395962011417 heme pocket [chemical binding]; other site 395962011418 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962011419 metal binding site [ion binding]; metal-binding site 395962011420 active site 395962011421 I-site; other site 395962011422 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962011423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962011424 active site 395962011425 phosphorylation site [posttranslational modification] 395962011426 intermolecular recognition site; other site 395962011427 dimerization interface [polypeptide binding]; other site 395962011428 PAS domain S-box; Region: sensory_box; TIGR00229 395962011429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962011430 putative active site [active] 395962011431 heme pocket [chemical binding]; other site 395962011432 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962011433 metal binding site [ion binding]; metal-binding site 395962011434 active site 395962011435 I-site; other site 395962011436 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962011437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395962011438 Response regulator receiver domain; Region: Response_reg; pfam00072 395962011439 active site 395962011440 phosphorylation site [posttranslational modification] 395962011441 intermolecular recognition site; other site 395962011442 dimerization interface [polypeptide binding]; other site 395962011443 PAS fold; Region: PAS_4; pfam08448 395962011444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395962011445 PAS fold; Region: PAS_4; pfam08448 395962011446 GAF domain; Region: GAF; cl15785 395962011447 PAS domain S-box; Region: sensory_box; TIGR00229 395962011448 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962011449 putative active site [active] 395962011450 heme pocket [chemical binding]; other site 395962011451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962011452 PAS fold; Region: PAS_3; pfam08447 395962011453 putative active site [active] 395962011454 heme pocket [chemical binding]; other site 395962011455 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395962011456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395962011457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395962011458 dimer interface [polypeptide binding]; other site 395962011459 phosphorylation site [posttranslational modification] 395962011460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395962011461 ATP binding site [chemical binding]; other site 395962011462 Mg2+ binding site [ion binding]; other site 395962011463 G-X-G motif; other site 395962011464 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 395962011465 Putative cyclase; Region: Cyclase; cl00814 395962011466 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 395962011467 Phosphoglycerate kinase; Region: PGK; pfam00162 395962011468 substrate binding site [chemical binding]; other site 395962011469 hinge regions; other site 395962011470 ADP binding site [chemical binding]; other site 395962011471 catalytic site [active] 395962011472 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 395962011473 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395962011474 RNA binding surface [nucleotide binding]; other site 395962011475 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 395962011476 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 395962011477 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 395962011478 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 395962011479 Substrate binding site; other site 395962011480 Mg++ binding site; other site 395962011481 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 395962011482 active site 395962011483 substrate binding site [chemical binding]; other site 395962011484 CoA binding site [chemical binding]; other site 395962011485 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 395962011486 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 395962011487 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 395962011488 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395962011489 RNA binding surface [nucleotide binding]; other site 395962011490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 395962011491 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 395962011492 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 395962011493 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 395962011494 Mg++ binding site [ion binding]; other site 395962011495 putative catalytic motif [active] 395962011496 putative substrate binding site [chemical binding]; other site 395962011497 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 395962011498 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 395962011499 active site 395962011500 Calx-beta domain; Region: Calx-beta; cl02522 395962011501 Calx-beta domain; Region: Calx-beta; cl02522 395962011502 Calx-beta domain; Region: Calx-beta; cl02522 395962011503 Calx-beta domain; Region: Calx-beta; cl02522 395962011504 Calx-beta domain; Region: Calx-beta; cl02522 395962011505 Calx-beta domain; Region: Calx-beta; cl02522 395962011506 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 395962011507 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 395962011508 metal binding site [ion binding]; metal-binding site 395962011509 dimer interface [polypeptide binding]; other site 395962011510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962011511 S-adenosylmethionine binding site [chemical binding]; other site 395962011512 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 395962011513 oligomerization interface [polypeptide binding]; other site 395962011514 active site 395962011515 metal binding site [ion binding]; metal-binding site 395962011516 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 395962011517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395962011518 S-adenosylmethionine binding site [chemical binding]; other site 395962011519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962011520 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 395962011521 RNA/DNA hybrid binding site [nucleotide binding]; other site 395962011522 active site 395962011523 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 395962011524 NMT1-like family; Region: NMT1_2; cl15260 395962011525 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 395962011526 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 395962011527 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 395962011528 putative active site [active] 395962011529 putative substrate binding site [chemical binding]; other site 395962011530 putative cosubstrate binding site; other site 395962011531 catalytic site [active] 395962011532 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 395962011533 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 395962011534 B12 binding site [chemical binding]; other site 395962011535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395962011536 FeS/SAM binding site; other site 395962011537 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 395962011538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395962011539 ATP binding site [chemical binding]; other site 395962011540 putative Mg++ binding site [ion binding]; other site 395962011541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395962011542 nucleotide binding region [chemical binding]; other site 395962011543 ATP-binding site [chemical binding]; other site 395962011544 large tegument protein UL36; Provisional; Region: PHA03246 395962011545 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 395962011546 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 395962011547 Ligand binding site; other site 395962011548 Putative Catalytic site; other site 395962011549 DXD motif; other site 395962011550 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 395962011551 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 395962011552 Ligand binding site; other site 395962011553 Putative Catalytic site; other site 395962011554 DXD motif; other site 395962011555 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 395962011556 Bacterial sugar transferase; Region: Bac_transf; cl00939 395962011557 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 395962011558 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 395962011559 ANP binding site [chemical binding]; other site 395962011560 Substrate Binding Site II [chemical binding]; other site 395962011561 Substrate Binding Site I [chemical binding]; other site 395962011562 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 395962011563 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 395962011564 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 395962011565 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962011566 putative active site [active] 395962011567 GTPase CgtA; Reviewed; Region: obgE; PRK12299 395962011568 GTP1/OBG; Region: GTP1_OBG; pfam01018 395962011569 Obg GTPase; Region: Obg; cd01898 395962011570 G1 box; other site 395962011571 GTP/Mg2+ binding site [chemical binding]; other site 395962011572 Switch I region; other site 395962011573 G2 box; other site 395962011574 G3 box; other site 395962011575 Switch II region; other site 395962011576 G4 box; other site 395962011577 G5 box; other site 395962011578 tellurium resistance terB-like protein; Region: terB_like; cd07177 395962011579 metal binding site [ion binding]; metal-binding site 395962011580 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 395962011581 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 395962011582 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 395962011583 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 395962011584 Walker A/P-loop; other site 395962011585 ATP binding site [chemical binding]; other site 395962011586 Q-loop/lid; other site 395962011587 ABC transporter signature motif; other site 395962011588 Walker B; other site 395962011589 D-loop; other site 395962011590 H-loop/switch region; other site 395962011591 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 395962011592 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 395962011593 Walker A/P-loop; other site 395962011594 ATP binding site [chemical binding]; other site 395962011595 Q-loop/lid; other site 395962011596 ABC transporter signature motif; other site 395962011597 Walker B; other site 395962011598 D-loop; other site 395962011599 H-loop/switch region; other site 395962011600 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 395962011601 NMT1-like family; Region: NMT1_2; cl15260 395962011602 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 395962011603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395962011604 dimer interface [polypeptide binding]; other site 395962011605 conserved gate region; other site 395962011606 putative PBP binding loops; other site 395962011607 ABC-ATPase subunit interface; other site 395962011608 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 395962011609 NMT1-like family; Region: NMT1_2; cl15260 395962011610 short chain dehydrogenase; Validated; Region: PRK08324 395962011611 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 395962011612 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 395962011613 putative NAD(P) binding site [chemical binding]; other site 395962011614 active site 395962011615 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 395962011616 active site 395962011617 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 395962011618 Cadmium resistance transporter; Region: Cad; cl04177 395962011619 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 395962011620 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 395962011621 Helix-turn-helix domains; Region: HTH; cl00088 395962011622 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 395962011623 putative dimerization interface [polypeptide binding]; other site 395962011624 Cadmium resistance transporter; Region: Cad; cl04177 395962011625 Domain of unknown function (DUF202); Region: DUF202; cl09954 395962011626 PAS fold; Region: PAS; pfam00989 395962011627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395962011628 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395962011629 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 395962011630 transmembrane helices; other site 395962011631 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 395962011632 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 395962011633 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 395962011634 Integral membrane protein TerC family; Region: TerC; cl10468 395962011635 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 395962011636 Cadmium resistance transporter; Region: Cad; cl04177 395962011637 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962011638 structural tetrad; other site 395962011639 FOG: WD40 repeat [General function prediction only]; Region: COG2319 395962011640 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395962011641 structural tetrad; other site 395962011642 coronin; Provisional; Region: PTZ00421 395962011643 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395962011644 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395962011645 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 395962011646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962011647 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 395962011648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962011649 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 395962011650 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 395962011651 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 395962011652 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 395962011653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395962011654 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 395962011655 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 395962011656 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 395962011657 shikimate binding site; other site 395962011658 NAD(P) binding site [chemical binding]; other site 395962011659 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 395962011660 dihydroorotase; Provisional; Region: PRK07575 395962011661 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395962011662 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 395962011663 active site 395962011664 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 395962011665 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 395962011666 Catalytic site [active] 395962011667 RNA polymerase sigma factor; Provisional; Region: PRK12518 395962011668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395962011669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395962011670 DNA binding residues [nucleotide binding] 395962011671 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 395962011672 dimer interface [polypeptide binding]; other site 395962011673 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 395962011674 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 395962011675 PAS domain S-box; Region: sensory_box; TIGR00229 395962011676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962011677 putative active site [active] 395962011678 heme pocket [chemical binding]; other site 395962011679 PAS domain S-box; Region: sensory_box; TIGR00229 395962011680 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962011681 putative active site [active] 395962011682 heme pocket [chemical binding]; other site 395962011683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395962011684 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 395962011685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395962011686 putative active site [active] 395962011687 heme pocket [chemical binding]; other site 395962011688 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 395962011689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395962011690 metal binding site [ion binding]; metal-binding site 395962011691 active site 395962011692 I-site; other site 395962011693 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395962011694 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395962011695 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 395962011696 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 395962011697 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 395962011698 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 395962011699 Protein of unknown function (DUF541); Region: SIMPL; cl01077 395962011700 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 395962011701 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962011702 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395962011703 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 395962011704 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 395962011705 putative active site [active] 395962011706 putative metal binding site [ion binding]; other site 395962011707 YGGT family; Region: YGGT; cl00508 395962011708 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 395962011709 dimer interface [polypeptide binding]; other site 395962011710 catalytic triad [active] 395962011711 LemA family; Region: LemA; cl00742 395962011712 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 395962011713 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 395962011714 Ligand binding site; other site 395962011715 Putative Catalytic site; other site 395962011716 DXD motif; other site 395962011717 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 395962011718 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 395962011719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 395962011720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 395962011721 Family of unknown function (DUF490); Region: DUF490; pfam04357 395962011722 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 395962011723 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395962011724 substrate binding pocket [chemical binding]; other site 395962011725 membrane-bound complex binding site; other site 395962011726 hinge residues; other site 395962011727 GXWXG protein; Region: GXWXG; pfam14231 395962011728 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 395962011729 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 395962011730 Stage II sporulation protein; Region: SpoIID; pfam08486 395962011731 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 395962011732 active site 395962011733 catalytic triad [active] 395962011734 oxyanion hole [active] 395962011735 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 395962011736 active site 395962011737 catalytic residues [active] 395962011738 metal binding site [ion binding]; metal-binding site 395962011739 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962011740 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395962011741 putative active site [active] 395962011742 Transposase domain (DUF772); Region: DUF772; cl15789 395962011743 Transposase domain (DUF772); Region: DUF772; cl15789 395962011744 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395962011745 oligomeric interface; other site 395962011746 putative active site [active] 395962011747 homodimer interface [polypeptide binding]; other site 395962011748 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 395962011749 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395962011750 DNA binding site [nucleotide binding] 395962011751 Int/Topo IB signature motif; other site 395962011752 active site 395962011753 Fic/DOC family; Region: Fic; cl00960 395962011754 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 395962011755 potential frameshift: common BLAST hit: gi|218249164|ref|YP_002374534.1| TOPRIM domain protein 395962011756 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 395962011757 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 395962011758 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 395962011759 active site 395962011760 metal binding site [ion binding]; metal-binding site 395962011761 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 395962011762 TPR repeat; Region: TPR_11; pfam13414 395962011763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962011764 binding surface 395962011765 TPR motif; other site 395962011766 TPR repeat; Region: TPR_11; pfam13414 395962011767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962011768 binding surface 395962011769 TPR motif; other site 395962011770 TPR repeat; Region: TPR_11; pfam13414 395962011771 TPR repeat; Region: TPR_11; pfam13414 395962011772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395962011773 binding surface 395962011774 TPR motif; other site 395962011775 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 395962011776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962011777 Walker A/P-loop; other site 395962011778 ATP binding site [chemical binding]; other site 395962011779 Q-loop/lid; other site 395962011780 ABC transporter signature motif; other site 395962011781 Walker B; other site 395962011782 D-loop; other site 395962011783 H-loop/switch region; other site 395962011784 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 395962011785 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395962011786 active site 395962011787 NTP binding site [chemical binding]; other site 395962011788 metal binding triad [ion binding]; metal-binding site 395962011789 antibiotic binding site [chemical binding]; other site 395962011790 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 395962011791 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 395962011792 DNA repair proteins Nse5 and Nse6; Region: Nse5; pfam08691 395962011793 GUN4-like; Region: GUN4; pfam05419 395962011794 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 395962011795 ParB-like nuclease domain; Region: ParBc; cl02129 395962011796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395962011797 Helix-turn-helix domains; Region: HTH; cl00088 395962011798 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395962011799 DNA binding site [nucleotide binding] 395962011800 Int/Topo IB signature motif; other site 395962011801 active site 395962011802 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395962011803 active site 395962011804 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 395962011805 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 395962011806 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 395962011807 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 395962011808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962011809 Probable transposase; Region: OrfB_IS605; pfam01385 395962011810 Peptidase family M23; Region: Peptidase_M23; pfam01551 395962011811 YcfA-like protein; Region: YcfA; cl00752 395962011812 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 395962011813 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395962011814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 395962011815 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 395962011816 GIY-YIG motif/motif A; other site 395962011817 active site 395962011818 catalytic site [active] 395962011819 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 395962011820 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 395962011821 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 395962011822 Transposase IS200 like; Region: Y1_Tnp; cl00848 395962011823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395962011824 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395962011825 Probable transposase; Region: OrfB_IS605; pfam01385 395962011826 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 395962011827 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 395962011828 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 395962011829 active site 395962011830 metal binding site [ion binding]; metal-binding site 395962011831 Helix-turn-helix domains; Region: HTH; cl00088 395962011832 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 395962011833 DNA binding site [nucleotide binding] 395962011834 Int/Topo IB signature motif; other site 395962011835 active site 395962011836 catalytic residues [active] 395962011837 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 395962011838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395962011839 Coenzyme A binding pocket [chemical binding]; other site 395962011840 Helix-turn-helix domains; Region: HTH; cl00088 395962011841 Protein of unknown function (DUF2281); Region: DUF2281; cl02355