-- dump date 20120504_143333 -- class Genbank::misc_feature -- table misc_feature_note -- id note 868595000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 868595000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 868595000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000004 Walker A motif; other site 868595000005 ATP binding site [chemical binding]; other site 868595000006 Walker B motif; other site 868595000007 arginine finger; other site 868595000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 868595000009 DnaA box-binding interface [nucleotide binding]; other site 868595000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 868595000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 868595000012 putative DNA binding surface [nucleotide binding]; other site 868595000013 dimer interface [polypeptide binding]; other site 868595000014 beta-clamp/clamp loader binding surface; other site 868595000015 beta-clamp/translesion DNA polymerase binding surface; other site 868595000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595000017 RNA binding surface [nucleotide binding]; other site 868595000018 recombination protein F; Reviewed; Region: recF; PRK00064 868595000019 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 868595000020 Walker A/P-loop; other site 868595000021 ATP binding site [chemical binding]; other site 868595000022 Q-loop/lid; other site 868595000023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595000024 ABC transporter signature motif; other site 868595000025 Walker B; other site 868595000026 D-loop; other site 868595000027 H-loop/switch region; other site 868595000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 868595000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595000030 Mg2+ binding site [ion binding]; other site 868595000031 G-X-G motif; other site 868595000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 868595000033 anchoring element; other site 868595000034 dimer interface [polypeptide binding]; other site 868595000035 ATP binding site [chemical binding]; other site 868595000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 868595000037 active site 868595000038 putative metal-binding site [ion binding]; other site 868595000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 868595000040 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 868595000041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595000042 S-adenosylmethionine binding site [chemical binding]; other site 868595000043 DNA gyrase subunit A; Validated; Region: PRK05560 868595000044 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 868595000045 CAP-like domain; other site 868595000046 active site 868595000047 primary dimer interface [polypeptide binding]; other site 868595000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000054 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595000055 Zn2+ binding site [ion binding]; other site 868595000056 Mg2+ binding site [ion binding]; other site 868595000057 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595000058 Zn2+ binding site [ion binding]; other site 868595000059 Mg2+ binding site [ion binding]; other site 868595000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 868595000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 868595000062 active site 868595000063 multimer interface [polypeptide binding]; other site 868595000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 868595000065 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 868595000066 predicted active site [active] 868595000067 catalytic triad [active] 868595000068 Accessory gene regulator B; Region: AgrB; cl01873 868595000069 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 868595000070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 868595000071 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 868595000072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595000073 dimer interface [polypeptide binding]; other site 868595000074 phosphorylation site [posttranslational modification] 868595000075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595000076 ATP binding site [chemical binding]; other site 868595000077 Mg2+ binding site [ion binding]; other site 868595000078 G-X-G motif; other site 868595000079 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 868595000080 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 868595000081 homodimer interface [polypeptide binding]; other site 868595000082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000083 catalytic residue [active] 868595000084 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 868595000085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000086 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 868595000087 putative L-serine binding site [chemical binding]; other site 868595000088 seryl-tRNA synthetase; Provisional; Region: PRK05431 868595000089 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 868595000090 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 868595000091 dimer interface [polypeptide binding]; other site 868595000092 active site 868595000093 motif 1; other site 868595000094 motif 2; other site 868595000095 motif 3; other site 868595000096 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 868595000097 nucleoside/Zn binding site; other site 868595000098 dimer interface [polypeptide binding]; other site 868595000099 catalytic motif [active] 868595000100 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595000101 Zn2+ binding site [ion binding]; other site 868595000102 Mg2+ binding site [ion binding]; other site 868595000103 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 868595000104 GIY-YIG motif/motif A; other site 868595000105 active site 868595000106 catalytic site [active] 868595000107 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 868595000108 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 868595000109 putative FMN binding site [chemical binding]; other site 868595000110 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 868595000111 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 868595000112 Cl- selectivity filter; other site 868595000113 Cl- binding residues [ion binding]; other site 868595000114 pore gating glutamate residue; other site 868595000115 dimer interface [polypeptide binding]; other site 868595000116 H+/Cl- coupling transport residue; other site 868595000117 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 868595000118 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 868595000119 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 868595000120 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 868595000121 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 868595000122 active site 868595000123 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 868595000124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000125 Walker A motif; other site 868595000126 ATP binding site [chemical binding]; other site 868595000127 Walker B motif; other site 868595000128 arginine finger; other site 868595000129 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 868595000130 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 868595000131 recombination protein RecR; Reviewed; Region: recR; PRK00076 868595000132 RecR protein; Region: RecR; pfam02132 868595000133 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 868595000134 putative active site [active] 868595000135 putative metal-binding site [ion binding]; other site 868595000136 tetramer interface [polypeptide binding]; other site 868595000137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595000138 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 868595000139 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 868595000140 dimer interface [polypeptide binding]; other site 868595000141 PYR/PP interface [polypeptide binding]; other site 868595000142 TPP binding site [chemical binding]; other site 868595000143 substrate binding site [chemical binding]; other site 868595000144 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 868595000145 TPP-binding site [chemical binding]; other site 868595000146 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 868595000147 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 868595000148 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595000149 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595000150 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 868595000151 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 868595000152 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 868595000153 homodimer interface [polypeptide binding]; other site 868595000154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000155 catalytic residue [active] 868595000156 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 868595000157 thymidylate kinase; Validated; Region: tmk; PRK00698 868595000158 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 868595000159 TMP-binding site; other site 868595000160 ATP-binding site [chemical binding]; other site 868595000161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000162 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 868595000163 Walker A motif; other site 868595000164 ATP binding site [chemical binding]; other site 868595000165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595000166 replication factor C small subunit 2; Reviewed; Region: PRK12402 868595000167 PSP1 C-terminal conserved region; Region: PSP1; cl00770 868595000168 Protein of unknown function (DUF972); Region: DUF972; pfam06156 868595000169 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 868595000170 Predicted methyltransferases [General function prediction only]; Region: COG0313 868595000171 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 868595000172 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 868595000173 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 868595000174 active site 868595000175 HIGH motif; other site 868595000176 KMSKS motif; other site 868595000177 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 868595000178 tRNA binding surface [nucleotide binding]; other site 868595000179 anticodon binding site; other site 868595000180 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 868595000181 active site 868595000182 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 868595000183 homodimer interface [polypeptide binding]; other site 868595000184 Walker A motif; other site 868595000185 ATP binding site [chemical binding]; other site 868595000186 hydroxycobalamin binding site [chemical binding]; other site 868595000187 Walker B motif; other site 868595000188 Putative cyclase; Region: Cyclase; cl00814 868595000189 Domain of unknown function (DUF348); Region: DUF348; pfam03990 868595000190 G5 domain; Region: G5; pfam07501 868595000191 3D domain; Region: 3D; cl01439 868595000192 Domain of unknown function (DUF348); Region: DUF348; pfam03990 868595000193 3D domain; Region: 3D; cl01439 868595000194 biotin synthase; Region: bioB; TIGR00433 868595000195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595000196 FeS/SAM binding site; other site 868595000197 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 868595000198 AAA domain; Region: AAA_26; pfam13500 868595000199 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595000200 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595000201 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 868595000202 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 868595000203 substrate-cofactor binding pocket; other site 868595000204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000205 catalytic residue [active] 868595000206 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 868595000207 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 868595000208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595000209 S-adenosylmethionine binding site [chemical binding]; other site 868595000210 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 868595000211 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 868595000212 inhibitor-cofactor binding pocket; inhibition site 868595000213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000214 catalytic residue [active] 868595000215 intracellular protease, PfpI family; Region: PfpI; TIGR01382 868595000216 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 868595000217 proposed catalytic triad [active] 868595000218 conserved cys residue [active] 868595000219 Sodium:solute symporter family; Region: SSF; cl00456 868595000220 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 868595000221 phosphate binding site [ion binding]; other site 868595000222 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 868595000223 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595000224 FeS/SAM binding site; other site 868595000225 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 868595000226 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 868595000227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000228 ATP binding site [chemical binding]; other site 868595000229 substrate interface [chemical binding]; other site 868595000230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000231 Protein of unknown function (DUF458); Region: DUF458; cl00861 868595000232 OsmC-like protein; Region: OsmC; cl00767 868595000233 YabG peptidase U57; Region: Peptidase_U57; cl05250 868595000234 Peptidase family S64; Region: Peptidase_S64; pfam08192 868595000235 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 868595000236 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 868595000237 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 868595000238 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 868595000239 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 868595000240 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595000241 putative peptidoglycan binding site; other site 868595000242 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 868595000243 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 868595000244 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 868595000245 Herpesvirus UL16/UL94 family; Region: Herpes_UL16; pfam03044 868595000246 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 868595000247 active site 868595000248 catalytic residues [active] 868595000249 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 868595000250 Protein of unknown function, DUF606; Region: DUF606; cl01273 868595000251 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 868595000252 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595000253 putative peptidoglycan binding site; other site 868595000254 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 868595000255 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 868595000256 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 868595000257 Transcriptional regulators [Transcription]; Region: GntR; COG1802 868595000258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 868595000259 DNA-binding site [nucleotide binding]; DNA binding site 868595000260 FCD domain; Region: FCD; cl11656 868595000261 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595000262 threonine dehydratase; Provisional; Region: PRK08198 868595000263 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 868595000264 tetramer interface [polypeptide binding]; other site 868595000265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000266 catalytic residue [active] 868595000267 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 868595000268 SpoVG; Region: SpoVG; cl00915 868595000269 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 868595000270 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 868595000271 Substrate binding site; other site 868595000272 Mg++ binding site; other site 868595000273 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 868595000274 active site 868595000275 substrate binding site [chemical binding]; other site 868595000276 CoA binding site [chemical binding]; other site 868595000277 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 868595000278 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 868595000279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595000280 active site 868595000281 Domain of unknown function DUF39; Region: DUF39; cl14897 868595000282 NIL domain; Region: NIL; cl09633 868595000283 4Fe-4S binding domain; Region: Fer4; cl02805 868595000284 ApbE family; Region: ApbE; cl00643 868595000285 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 868595000286 diiron binding motif [ion binding]; other site 868595000287 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 868595000288 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 868595000289 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 868595000290 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 868595000291 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 868595000292 5S rRNA interface [nucleotide binding]; other site 868595000293 CTC domain interface [polypeptide binding]; other site 868595000294 L16 interface [polypeptide binding]; other site 868595000295 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 868595000296 putative active site [active] 868595000297 catalytic residue [active] 868595000298 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 868595000299 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 868595000300 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595000301 ATP binding site [chemical binding]; other site 868595000302 putative Mg++ binding site [ion binding]; other site 868595000303 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595000304 nucleotide binding region [chemical binding]; other site 868595000305 ATP-binding site [chemical binding]; other site 868595000306 TRCF domain; Region: TRCF; cl04088 868595000307 SurA N-terminal domain; Region: SurA_N_3; cl07813 868595000308 PPIC-type PPIASE domain; Region: Rotamase; cl08278 868595000309 stage V sporulation protein T; Region: spore_V_T; TIGR02851 868595000310 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 868595000311 GAF domain; Region: GAF; cl15785 868595000312 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 868595000313 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 868595000314 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 868595000315 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 868595000316 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 868595000317 IHF dimer interface [polypeptide binding]; other site 868595000318 IHF - DNA interface [nucleotide binding]; other site 868595000319 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595000320 RNA binding surface [nucleotide binding]; other site 868595000321 Stage II sporulation protein; Region: SpoIID; pfam08486 868595000322 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 868595000323 YabP family; Region: YabP; cl06766 868595000324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 868595000325 Septum formation initiator; Region: DivIC; cl11433 868595000326 hypothetical protein; Provisional; Region: PRK08582 868595000327 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 868595000328 RNA binding site [nucleotide binding]; other site 868595000329 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 868595000330 stage II sporulation protein E; Region: spore_II_E; TIGR02865 868595000331 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 868595000332 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 868595000333 B3/4 domain; Region: B3_4; cl11458 868595000334 FtsH Extracellular; Region: FtsH_ext; pfam06480 868595000335 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 868595000336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000337 Walker A motif; other site 868595000338 ATP binding site [chemical binding]; other site 868595000339 Walker B motif; other site 868595000340 arginine finger; other site 868595000341 Peptidase family M41; Region: Peptidase_M41; pfam01434 868595000342 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595000343 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595000344 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 868595000345 active site 868595000346 multimer interface [polypeptide binding]; other site 868595000347 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 868595000348 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 868595000349 amphipathic channel; other site 868595000350 Asn-Pro-Ala signature motifs; other site 868595000351 glycerol kinase; Provisional; Region: glpK; PRK00047 868595000352 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 868595000353 N- and C-terminal domain interface [polypeptide binding]; other site 868595000354 active site 868595000355 MgATP binding site [chemical binding]; other site 868595000356 catalytic site [active] 868595000357 metal binding site [ion binding]; metal-binding site 868595000358 glycerol binding site [chemical binding]; other site 868595000359 homotetramer interface [polypeptide binding]; other site 868595000360 homodimer interface [polypeptide binding]; other site 868595000361 FBP binding site [chemical binding]; other site 868595000362 protein IIAGlc interface [polypeptide binding]; other site 868595000363 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 868595000364 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 868595000365 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 868595000366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000367 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 868595000368 Cysteine-rich domain; Region: CCG; pfam02754 868595000369 Cysteine-rich domain; Region: CCG; pfam02754 868595000370 pyruvate kinase; Provisional; Region: PRK06354 868595000371 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 868595000372 domain interfaces; other site 868595000373 active site 868595000374 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 868595000375 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 868595000376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 868595000377 DNA-binding site [nucleotide binding]; DNA binding site 868595000378 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 868595000379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000380 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 868595000381 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 868595000382 Phosphoglycerate kinase; Region: PGK; pfam00162 868595000383 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 868595000384 substrate binding site [chemical binding]; other site 868595000385 hinge regions; other site 868595000386 ADP binding site [chemical binding]; other site 868595000387 catalytic site [active] 868595000388 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 868595000389 substrate binding site [chemical binding]; other site 868595000390 dimer interface [polypeptide binding]; other site 868595000391 catalytic triad [active] 868595000392 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 868595000393 Sulfatase; Region: Sulfatase; cl10460 868595000394 enolase; Provisional; Region: eno; PRK00077 868595000395 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 868595000396 dimer interface [polypeptide binding]; other site 868595000397 metal binding site [ion binding]; metal-binding site 868595000398 substrate binding pocket [chemical binding]; other site 868595000399 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595000400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000401 4Fe-4S binding domain; Region: Fer4; cl02805 868595000402 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595000403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000404 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595000405 4Fe-4S binding domain; Region: Fer4; cl02805 868595000406 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 868595000407 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 868595000408 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 868595000409 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 868595000410 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 868595000411 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 868595000412 FAD binding pocket [chemical binding]; other site 868595000413 FAD binding motif [chemical binding]; other site 868595000414 phosphate binding motif [ion binding]; other site 868595000415 beta-alpha-beta structure motif; other site 868595000416 NAD binding pocket [chemical binding]; other site 868595000417 Iron coordination center [ion binding]; other site 868595000418 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595000419 Cysteine-rich domain; Region: CCG; pfam02754 868595000420 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595000421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000422 4Fe-4S binding domain; Region: Fer4; cl02805 868595000423 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595000424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000425 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595000426 4Fe-4S binding domain; Region: Fer4; cl02805 868595000427 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 868595000428 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 868595000429 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 868595000430 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 868595000431 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 868595000432 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 868595000433 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 868595000434 FAD binding pocket [chemical binding]; other site 868595000435 FAD binding motif [chemical binding]; other site 868595000436 phosphate binding motif [ion binding]; other site 868595000437 beta-alpha-beta structure motif; other site 868595000438 NAD binding pocket [chemical binding]; other site 868595000439 Iron coordination center [ion binding]; other site 868595000440 Transposase domain (DUF772); Region: DUF772; cl15789 868595000441 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595000442 Transposase domain (DUF772); Region: DUF772; cl15789 868595000443 Transposase domain (DUF772); Region: DUF772; cl15789 868595000444 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 868595000445 CoenzymeA binding site [chemical binding]; other site 868595000446 subunit interaction site [polypeptide binding]; other site 868595000447 PHB binding site; other site 868595000448 FOG: CBS domain [General function prediction only]; Region: COG0517 868595000449 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 868595000450 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 868595000451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595000452 putative active site [active] 868595000453 heme pocket [chemical binding]; other site 868595000454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000455 Walker A motif; other site 868595000456 ATP binding site [chemical binding]; other site 868595000457 Walker B motif; other site 868595000458 arginine finger; other site 868595000459 Sodium:solute symporter family; Region: SSF; cl00456 868595000460 OsmC-like protein; Region: OsmC; cl00767 868595000461 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 868595000462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000463 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595000464 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 868595000465 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 868595000466 FMN binding site [chemical binding]; other site 868595000467 dimer interface [polypeptide binding]; other site 868595000468 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 868595000469 dihydropteroate synthase; Region: DHPS; TIGR01496 868595000470 substrate binding pocket [chemical binding]; other site 868595000471 dimer interface [polypeptide binding]; other site 868595000472 inhibitor binding site; inhibition site 868595000473 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 868595000474 homooctamer interface [polypeptide binding]; other site 868595000475 active site 868595000476 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 868595000477 catalytic center binding site [active] 868595000478 ATP binding site [chemical binding]; other site 868595000479 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 868595000480 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 868595000481 active site 868595000482 NTP binding site [chemical binding]; other site 868595000483 metal binding triad [ion binding]; metal-binding site 868595000484 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 868595000485 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595000486 Zn2+ binding site [ion binding]; other site 868595000487 Mg2+ binding site [ion binding]; other site 868595000488 Uncharacterized conserved protein [Function unknown]; Region: COG5495 868595000489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000490 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 868595000491 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 868595000492 oligomerization interface [polypeptide binding]; other site 868595000493 active site 868595000494 metal binding site [ion binding]; metal-binding site 868595000495 pantoate--beta-alanine ligase; Region: panC; TIGR00018 868595000496 Pantoate-beta-alanine ligase; Region: PanC; cd00560 868595000497 active site 868595000498 ATP-binding site [chemical binding]; other site 868595000499 pantoate-binding site; other site 868595000500 HXXH motif; other site 868595000501 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 868595000502 tetramerization interface [polypeptide binding]; other site 868595000503 active site 868595000504 Quinolinate synthetase A protein; Region: NadA; cl00420 868595000505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000506 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 868595000507 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 868595000508 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 868595000509 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 868595000510 dimerization interface [polypeptide binding]; other site 868595000511 active site 868595000512 Helix-turn-helix domains; Region: HTH; cl00088 868595000513 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 868595000514 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 868595000515 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 868595000516 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 868595000517 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 868595000518 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595000519 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595000520 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595000521 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595000522 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595000523 DNA binding residues [nucleotide binding] 868595000524 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595000525 catalytic residues [active] 868595000526 catalytic nucleophile [active] 868595000527 Type III pantothenate kinase; Region: Pan_kinase; cl09130 868595000528 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 868595000529 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 868595000530 FMN binding site [chemical binding]; other site 868595000531 active site 868595000532 catalytic residues [active] 868595000533 substrate binding site [chemical binding]; other site 868595000534 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 868595000535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000536 NAD(P) binding pocket [chemical binding]; other site 868595000537 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 868595000538 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 868595000539 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 868595000540 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 868595000541 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 868595000542 dimer interface [polypeptide binding]; other site 868595000543 putative anticodon binding site; other site 868595000544 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 868595000545 motif 1; other site 868595000546 active site 868595000547 motif 2; other site 868595000548 motif 3; other site 868595000549 Predicted membrane protein [Function unknown]; Region: COG2860 868595000550 UPF0126 domain; Region: UPF0126; pfam03458 868595000551 UPF0126 domain; Region: UPF0126; pfam03458 868595000552 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 868595000553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000554 Walker A motif; other site 868595000555 ATP binding site [chemical binding]; other site 868595000556 Walker B motif; other site 868595000557 arginine finger; other site 868595000558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000559 Walker A motif; other site 868595000560 ATP binding site [chemical binding]; other site 868595000561 Walker B motif; other site 868595000562 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 868595000563 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 868595000564 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 868595000565 UvrB/uvrC motif; Region: UVR; pfam02151 868595000566 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 868595000567 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 868595000568 ADP binding site [chemical binding]; other site 868595000569 phosphagen binding site; other site 868595000570 substrate specificity loop; other site 868595000571 Clp protease ATP binding subunit; Region: clpC; CHL00095 868595000572 Clp amino terminal domain; Region: Clp_N; pfam02861 868595000573 Clp amino terminal domain; Region: Clp_N; pfam02861 868595000574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000575 Walker A motif; other site 868595000576 ATP binding site [chemical binding]; other site 868595000577 Walker B motif; other site 868595000578 arginine finger; other site 868595000579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000580 Walker A motif; other site 868595000581 ATP binding site [chemical binding]; other site 868595000582 Walker B motif; other site 868595000583 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 868595000584 DNA repair protein RadA; Provisional; Region: PRK11823 868595000585 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 868595000586 Walker A motif/ATP binding site; other site 868595000587 ATP binding site [chemical binding]; other site 868595000588 Walker B motif; other site 868595000589 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 868595000590 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 868595000591 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 868595000592 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 868595000593 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 868595000594 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 868595000595 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 868595000596 putative active site [active] 868595000597 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 868595000598 substrate binding site; other site 868595000599 dimer interface; other site 868595000600 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 868595000601 homotrimer interaction site [polypeptide binding]; other site 868595000602 zinc binding site [ion binding]; other site 868595000603 CDP-binding sites; other site 868595000604 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 868595000605 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 868595000606 active site 868595000607 HIGH motif; other site 868595000608 nucleotide binding site [chemical binding]; other site 868595000609 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 868595000610 KMSKS motif; other site 868595000611 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 868595000612 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 868595000613 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 868595000614 HIGH motif; other site 868595000615 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 868595000616 active site 868595000617 KMSKS motif; other site 868595000618 serine O-acetyltransferase; Region: cysE; TIGR01172 868595000619 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 868595000620 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 868595000621 trimer interface [polypeptide binding]; other site 868595000622 active site 868595000623 substrate binding site [chemical binding]; other site 868595000624 CoA binding site [chemical binding]; other site 868595000625 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 868595000626 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 868595000627 active site 868595000628 HIGH motif; other site 868595000629 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 868595000630 KMSKS motif; other site 868595000631 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 868595000632 tRNA binding surface [nucleotide binding]; other site 868595000633 anticodon binding site; other site 868595000634 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 868595000635 active site 868595000636 metal binding site [ion binding]; metal-binding site 868595000637 dimerization interface [polypeptide binding]; other site 868595000638 Thymidylate synthase complementing protein; Region: Thy1; cl03630 868595000639 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 868595000640 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 868595000641 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 868595000642 YacP-like NYN domain; Region: NYN_YacP; cl01491 868595000643 RNA polymerase factor sigma-70; Validated; Region: PRK08295 868595000644 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595000645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 868595000646 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 868595000647 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 868595000648 putative active site [active] 868595000649 putative NTP binding site [chemical binding]; other site 868595000650 putative nucleic acid binding site [nucleotide binding]; other site 868595000651 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 868595000652 elongation factor Tu; Reviewed; Region: PRK00049 868595000653 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 868595000654 G1 box; other site 868595000655 GEF interaction site [polypeptide binding]; other site 868595000656 GTP/Mg2+ binding site [chemical binding]; other site 868595000657 Switch I region; other site 868595000658 G2 box; other site 868595000659 G3 box; other site 868595000660 Switch II region; other site 868595000661 G4 box; other site 868595000662 G5 box; other site 868595000663 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 868595000664 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 868595000665 Antibiotic Binding Site [chemical binding]; other site 868595000666 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 868595000667 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 868595000668 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 868595000669 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 868595000670 putative homodimer interface [polypeptide binding]; other site 868595000671 KOW motif; Region: KOW; cl00354 868595000672 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 868595000673 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 868595000674 23S rRNA interface [nucleotide binding]; other site 868595000675 L7/L12 interface [polypeptide binding]; other site 868595000676 putative thiostrepton binding site; other site 868595000677 L25 interface [polypeptide binding]; other site 868595000678 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 868595000679 mRNA/rRNA interface [nucleotide binding]; other site 868595000680 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 868595000681 23S rRNA interface [nucleotide binding]; other site 868595000682 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 868595000683 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 868595000684 peripheral dimer interface [polypeptide binding]; other site 868595000685 core dimer interface [polypeptide binding]; other site 868595000686 L10 interface [polypeptide binding]; other site 868595000687 L11 interface [polypeptide binding]; other site 868595000688 putative EF-Tu interaction site [polypeptide binding]; other site 868595000689 putative EF-G interaction site [polypeptide binding]; other site 868595000690 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 868595000691 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 868595000692 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 868595000693 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 868595000694 RPB1 interaction site [polypeptide binding]; other site 868595000695 RPB10 interaction site [polypeptide binding]; other site 868595000696 RPB11 interaction site [polypeptide binding]; other site 868595000697 RPB3 interaction site [polypeptide binding]; other site 868595000698 RPB12 interaction site [polypeptide binding]; other site 868595000699 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 868595000700 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 868595000701 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 868595000702 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 868595000703 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 868595000704 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 868595000705 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 868595000706 G-loop; other site 868595000707 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 868595000708 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 868595000709 DNA binding site [nucleotide binding] 868595000710 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 868595000711 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 868595000712 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 868595000713 S17 interaction site [polypeptide binding]; other site 868595000714 S8 interaction site; other site 868595000715 16S rRNA interaction site [nucleotide binding]; other site 868595000716 streptomycin interaction site [chemical binding]; other site 868595000717 23S rRNA interaction site [nucleotide binding]; other site 868595000718 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 868595000719 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 868595000720 elongation factor G; Reviewed; Region: PRK00007 868595000721 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 868595000722 G1 box; other site 868595000723 putative GEF interaction site [polypeptide binding]; other site 868595000724 GTP/Mg2+ binding site [chemical binding]; other site 868595000725 Switch I region; other site 868595000726 G2 box; other site 868595000727 G3 box; other site 868595000728 Switch II region; other site 868595000729 G4 box; other site 868595000730 G5 box; other site 868595000731 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 868595000732 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 868595000733 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 868595000734 elongation factor Tu; Reviewed; Region: PRK00049 868595000735 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 868595000736 G1 box; other site 868595000737 GEF interaction site [polypeptide binding]; other site 868595000738 GTP/Mg2+ binding site [chemical binding]; other site 868595000739 Switch I region; other site 868595000740 G2 box; other site 868595000741 G3 box; other site 868595000742 Switch II region; other site 868595000743 G4 box; other site 868595000744 G5 box; other site 868595000745 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 868595000746 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 868595000747 Antibiotic Binding Site [chemical binding]; other site 868595000748 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 868595000749 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 868595000750 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 868595000751 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 868595000752 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 868595000753 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 868595000754 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 868595000755 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 868595000756 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 868595000757 putative translocon binding site; other site 868595000758 protein-rRNA interface [nucleotide binding]; other site 868595000759 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 868595000760 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 868595000761 G-X-X-G motif; other site 868595000762 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 868595000763 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 868595000764 23S rRNA interface [nucleotide binding]; other site 868595000765 5S rRNA interface [nucleotide binding]; other site 868595000766 putative antibiotic binding site [chemical binding]; other site 868595000767 L25 interface [polypeptide binding]; other site 868595000768 L27 interface [polypeptide binding]; other site 868595000769 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 868595000770 23S rRNA interface [nucleotide binding]; other site 868595000771 putative translocon interaction site; other site 868595000772 signal recognition particle (SRP54) interaction site; other site 868595000773 L23 interface [polypeptide binding]; other site 868595000774 trigger factor interaction site; other site 868595000775 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 868595000776 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 868595000777 KOW motif; Region: KOW; cl00354 868595000778 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 868595000779 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 868595000780 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 868595000781 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 868595000782 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 868595000783 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 868595000784 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 868595000785 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 868595000786 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 868595000787 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 868595000788 23S rRNA interface [nucleotide binding]; other site 868595000789 5S rRNA interface [nucleotide binding]; other site 868595000790 L27 interface [polypeptide binding]; other site 868595000791 L5 interface [polypeptide binding]; other site 868595000792 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 868595000793 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 868595000794 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 868595000795 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 868595000796 23S rRNA binding site [nucleotide binding]; other site 868595000797 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 868595000798 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 868595000799 SecY translocase; Region: SecY; pfam00344 868595000800 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 868595000801 active site 868595000802 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 868595000803 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 868595000804 rRNA binding site [nucleotide binding]; other site 868595000805 predicted 30S ribosome binding site; other site 868595000806 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 868595000807 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 868595000808 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 868595000809 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 868595000810 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 868595000811 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 868595000812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595000813 RNA binding surface [nucleotide binding]; other site 868595000814 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 868595000815 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 868595000816 alphaNTD homodimer interface [polypeptide binding]; other site 868595000817 alphaNTD - beta interaction site [polypeptide binding]; other site 868595000818 alphaNTD - beta' interaction site [polypeptide binding]; other site 868595000819 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 868595000820 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 868595000821 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 868595000822 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 868595000823 Walker A/P-loop; other site 868595000824 ATP binding site [chemical binding]; other site 868595000825 Q-loop/lid; other site 868595000826 ABC transporter signature motif; other site 868595000827 Walker B; other site 868595000828 D-loop; other site 868595000829 H-loop/switch region; other site 868595000830 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 868595000831 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 868595000832 Walker A/P-loop; other site 868595000833 ATP binding site [chemical binding]; other site 868595000834 Q-loop/lid; other site 868595000835 ABC transporter signature motif; other site 868595000836 Walker B; other site 868595000837 D-loop; other site 868595000838 H-loop/switch region; other site 868595000839 Cobalt transport protein; Region: CbiQ; cl00463 868595000840 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 868595000841 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 868595000842 dimerization interface 3.5A [polypeptide binding]; other site 868595000843 active site 868595000844 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 868595000845 23S rRNA interface [nucleotide binding]; other site 868595000846 L3 interface [polypeptide binding]; other site 868595000847 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 868595000848 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 868595000849 active site 868595000850 metal binding site [ion binding]; metal-binding site 868595000851 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 868595000852 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 868595000853 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 868595000854 catalytic residue [active] 868595000855 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 868595000856 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 868595000857 LysE type translocator; Region: LysE; cl00565 868595000858 hypothetical protein; Provisional; Region: PRK03881 868595000859 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 868595000860 AMMECR1; Region: AMMECR1; cl00911 868595000861 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 868595000862 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595000863 FeS/SAM binding site; other site 868595000864 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 868595000865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000866 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 868595000867 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 868595000868 heterotetramer interface [polypeptide binding]; other site 868595000869 active site pocket [active] 868595000870 cleavage site 868595000871 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 868595000872 feedback inhibition sensing region; other site 868595000873 homohexameric interface [polypeptide binding]; other site 868595000874 nucleotide binding site [chemical binding]; other site 868595000875 N-acetyl-L-glutamate binding site [chemical binding]; other site 868595000876 acetylornithine aminotransferase; Provisional; Region: PRK02627 868595000877 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 868595000878 inhibitor-cofactor binding pocket; inhibition site 868595000879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000880 catalytic residue [active] 868595000881 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 868595000882 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 868595000883 ATP-grasp domain; Region: ATP-grasp_4; cl03087 868595000884 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 868595000885 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 868595000886 ATP-grasp domain; Region: ATP-grasp_4; cl03087 868595000887 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 868595000888 substrate binding site [chemical binding]; other site 868595000889 ornithine carbamoyltransferase; Provisional; Region: PRK00779 868595000890 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 868595000891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000892 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 868595000893 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 868595000894 ANP binding site [chemical binding]; other site 868595000895 Substrate Binding Site II [chemical binding]; other site 868595000896 Substrate Binding Site I [chemical binding]; other site 868595000897 argininosuccinate lyase; Provisional; Region: PRK00855 868595000898 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 868595000899 active sites [active] 868595000900 tetramer interface [polypeptide binding]; other site 868595000901 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595000902 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595000903 DNA binding residues [nucleotide binding] 868595000904 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595000905 catalytic residues [active] 868595000906 catalytic nucleophile [active] 868595000907 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 868595000908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 868595000909 Probable transposase; Region: OrfB_IS605; pfam01385 868595000910 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 868595000911 Uncharacterized conserved protein [Function unknown]; Region: COG4715 868595000912 SWIM zinc finger; Region: SWIM; cl15408 868595000913 Flagellin N-methylase; Region: FliB; cl00497 868595000914 Dehydratase family; Region: ILVD_EDD; cl00340 868595000915 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 868595000916 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 868595000917 PYR/PP interface [polypeptide binding]; other site 868595000918 dimer interface [polypeptide binding]; other site 868595000919 TPP binding site [chemical binding]; other site 868595000920 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 868595000921 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 868595000922 TPP-binding site [chemical binding]; other site 868595000923 dimer interface [polypeptide binding]; other site 868595000924 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 868595000925 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 868595000926 putative valine binding site [chemical binding]; other site 868595000927 dimer interface [polypeptide binding]; other site 868595000928 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 868595000929 ketol-acid reductoisomerase; Provisional; Region: PRK05479 868595000930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000931 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 868595000932 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 868595000933 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 868595000934 PYR/PP interface [polypeptide binding]; other site 868595000935 dimer interface [polypeptide binding]; other site 868595000936 TPP binding site [chemical binding]; other site 868595000937 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 868595000938 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 868595000939 TPP-binding site [chemical binding]; other site 868595000940 dimer interface [polypeptide binding]; other site 868595000941 2-isopropylmalate synthase; Validated; Region: PRK00915 868595000942 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 868595000943 active site 868595000944 catalytic residues [active] 868595000945 metal binding site [ion binding]; metal-binding site 868595000946 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 868595000947 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 868595000948 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 868595000949 substrate binding site [chemical binding]; other site 868595000950 ligand binding site [chemical binding]; other site 868595000951 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 868595000952 substrate binding site [chemical binding]; other site 868595000953 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 868595000954 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 868595000955 tartrate dehydrogenase; Provisional; Region: PRK08194 868595000956 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 868595000957 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 868595000958 active site 868595000959 catalytic residues [active] 868595000960 metal binding site [ion binding]; metal-binding site 868595000961 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 868595000962 Uncharacterized conserved protein [Function unknown]; Region: COG1624 868595000963 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 868595000964 YbbR-like protein; Region: YbbR; pfam07949 868595000965 YbbR-like protein; Region: YbbR; pfam07949 868595000966 YbbR-like protein; Region: YbbR; pfam07949 868595000967 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 868595000968 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 868595000969 active site 868595000970 substrate binding site [chemical binding]; other site 868595000971 metal binding site [ion binding]; metal-binding site 868595000972 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 868595000973 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 868595000974 glutaminase active site [active] 868595000975 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 868595000976 dimer interface [polypeptide binding]; other site 868595000977 active site 868595000978 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 868595000979 dimer interface [polypeptide binding]; other site 868595000980 active site 868595000981 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 868595000982 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 868595000983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595000984 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 868595000985 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 868595000986 HerA helicase [Replication, recombination, and repair]; Region: COG0433 868595000987 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 868595000988 Domain of unknown function DUF87; Region: DUF87; pfam01935 868595000989 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 868595000990 Catalytic domain of Protein Kinases; Region: PKc; cd00180 868595000991 active site 868595000992 ATP binding site [chemical binding]; other site 868595000993 substrate binding site [chemical binding]; other site 868595000994 activation loop (A-loop); other site 868595000995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 868595000996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595000997 TPR motif; other site 868595000998 Tetratricopeptide repeat; Region: TPR_16; pfam13432 868595000999 binding surface 868595001000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 868595001001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 868595001002 Integrase core domain; Region: rve; cl01316 868595001003 transposase/IS protein; Provisional; Region: PRK09183 868595001004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595001005 Walker A motif; other site 868595001006 ATP binding site [chemical binding]; other site 868595001007 Walker B motif; other site 868595001008 Protein of unknown function DUF262; Region: DUF262; cl14890 868595001009 Protein of unknown function DUF262; Region: DUF262; cl14890 868595001010 Catalytic GIY-YIG domain of coliphage T4 non-specific endonuclease II, type II restriction endonuclease R.Hpy188I, and similar proteins; Region: GIY-YIG_EndoII_Hpy188I_like; cd10436 868595001011 GIY-YIG motif/motif A; other site 868595001012 DNA binding site [nucleotide binding] 868595001013 active site 868595001014 catalytic site [active] 868595001015 metal binding site [ion binding]; metal-binding site 868595001016 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 868595001017 Helix-turn-helix domains; Region: HTH; cl00088 868595001018 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 868595001019 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595001020 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 868595001021 active site 868595001022 metal binding site [ion binding]; metal-binding site 868595001023 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 868595001024 dimer interface [polypeptide binding]; other site 868595001025 Alkaline phosphatase homologues; Region: alkPPc; smart00098 868595001026 active site 868595001027 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595001028 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 868595001029 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 868595001030 trimerization site [polypeptide binding]; other site 868595001031 active site 868595001032 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 868595001033 active site 868595001034 metal binding site [ion binding]; metal-binding site 868595001035 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 868595001036 NodB motif; other site 868595001037 putative active site [active] 868595001038 putative catalytic site [active] 868595001039 Zn binding site [ion binding]; other site 868595001040 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 868595001041 NodB motif; other site 868595001042 active site 868595001043 catalytic site [active] 868595001044 metal binding site [ion binding]; metal-binding site 868595001045 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 868595001046 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 868595001047 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 868595001048 Protein export membrane protein; Region: SecD_SecF; cl14618 868595001049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 868595001050 Helix-turn-helix domains; Region: HTH; cl00088 868595001051 DNA binding site [nucleotide binding] 868595001052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 868595001053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595001054 dimerization interface [polypeptide binding]; other site 868595001055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595001056 dimer interface [polypeptide binding]; other site 868595001057 phosphorylation site [posttranslational modification] 868595001058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595001059 ATP binding site [chemical binding]; other site 868595001060 Mg2+ binding site [ion binding]; other site 868595001061 G-X-G motif; other site 868595001062 Short C-terminal domain; Region: SHOCT; cl01373 868595001063 CrcB-like protein; Region: CRCB; cl09114 868595001064 CrcB-like protein; Region: CRCB; cl09114 868595001065 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 868595001066 Ligand Binding Site [chemical binding]; other site 868595001067 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 868595001068 active site 868595001069 Predicted permease; Region: DUF318; pfam03773 868595001070 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 868595001071 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 868595001072 Walker A/P-loop; other site 868595001073 ATP binding site [chemical binding]; other site 868595001074 Q-loop/lid; other site 868595001075 ABC transporter signature motif; other site 868595001076 Walker B; other site 868595001077 D-loop; other site 868595001078 H-loop/switch region; other site 868595001079 Cobalt transport protein; Region: CbiQ; cl00463 868595001080 Cobalt transport protein component CbiN; Region: CbiN; cl00842 868595001081 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 868595001082 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 868595001083 Helix-turn-helix domains; Region: HTH; cl00088 868595001084 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 868595001085 putative dimerization interface [polypeptide binding]; other site 868595001086 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 868595001087 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 868595001088 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 868595001089 ligand binding site [chemical binding]; other site 868595001090 flexible hinge region; other site 868595001091 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 868595001092 putative switch regulator; other site 868595001093 non-specific DNA interactions [nucleotide binding]; other site 868595001094 DNA binding site [nucleotide binding] 868595001095 sequence specific DNA binding site [nucleotide binding]; other site 868595001096 putative cAMP binding site [chemical binding]; other site 868595001097 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 868595001098 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 868595001099 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 868595001100 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 868595001101 NADH dehydrogenase subunit M; Validated; Region: PRK08668 868595001102 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 868595001103 NADH dehydrogenase; Region: NADHdh; cl00469 868595001104 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 868595001105 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 868595001106 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595001107 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 868595001108 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 868595001109 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 868595001110 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 868595001111 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 868595001112 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 868595001113 4Fe-4S binding domain; Region: Fer4; cl02805 868595001114 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 868595001115 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 868595001116 ACS interaction site; other site 868595001117 CODH interaction site; other site 868595001118 cubane metal cluster (B-cluster) [ion binding]; other site 868595001119 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 868595001120 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 868595001121 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 868595001122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001124 Acylphosphatase; Region: Acylphosphatase; cl00551 868595001125 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 868595001126 HypF finger; Region: zf-HYPF; pfam07503 868595001127 HypF finger; Region: zf-HYPF; pfam07503 868595001128 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 868595001129 HupF/HypC family; Region: HupF_HypC; cl00394 868595001130 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 868595001131 Hydrogenase formation hypA family; Region: HypD; cl12072 868595001132 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 868595001133 dimerization interface [polypeptide binding]; other site 868595001134 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 868595001135 ATP binding site [chemical binding]; other site 868595001136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595001137 dimer interface [polypeptide binding]; other site 868595001138 phosphorylation site [posttranslational modification] 868595001139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595001140 ATP binding site [chemical binding]; other site 868595001141 Mg2+ binding site [ion binding]; other site 868595001142 G-X-G motif; other site 868595001143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595001144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001145 active site 868595001146 phosphorylation site [posttranslational modification] 868595001147 intermolecular recognition site; other site 868595001148 dimerization interface [polypeptide binding]; other site 868595001149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595001150 DNA binding site [nucleotide binding] 868595001151 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 868595001152 active site 868595001153 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 868595001154 active site 868595001155 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 868595001156 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 868595001157 active site 868595001158 dimer interfaces [polypeptide binding]; other site 868595001159 catalytic residues [active] 868595001160 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 868595001161 PhoU domain; Region: PhoU; pfam01895 868595001162 PhoU domain; Region: PhoU; pfam01895 868595001163 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 868595001164 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 868595001165 Walker A/P-loop; other site 868595001166 ATP binding site [chemical binding]; other site 868595001167 Q-loop/lid; other site 868595001168 ABC transporter signature motif; other site 868595001169 Walker B; other site 868595001170 D-loop; other site 868595001171 H-loop/switch region; other site 868595001172 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 868595001173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595001174 dimer interface [polypeptide binding]; other site 868595001175 conserved gate region; other site 868595001176 putative PBP binding loops; other site 868595001177 ABC-ATPase subunit interface; other site 868595001178 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 868595001179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595001180 dimer interface [polypeptide binding]; other site 868595001181 conserved gate region; other site 868595001182 putative PBP binding loops; other site 868595001183 ABC-ATPase subunit interface; other site 868595001184 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595001185 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 868595001186 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 868595001187 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 868595001188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 868595001189 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 868595001190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 868595001191 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 868595001192 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 868595001193 G1 box; other site 868595001194 putative GEF interaction site [polypeptide binding]; other site 868595001195 GTP/Mg2+ binding site [chemical binding]; other site 868595001196 Switch I region; other site 868595001197 G2 box; other site 868595001198 G3 box; other site 868595001199 Switch II region; other site 868595001200 G4 box; other site 868595001201 G5 box; other site 868595001202 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 868595001203 Predicted membrane protein [Function unknown]; Region: COG4905 868595001204 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 868595001205 Ligand binding site [chemical binding]; other site 868595001206 Electron transfer flavoprotein domain; Region: ETF; pfam01012 868595001207 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595001208 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 868595001209 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 868595001210 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 868595001211 oxidoreductase; Provisional; Region: PRK10015 868595001212 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 868595001213 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 868595001214 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 868595001215 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 868595001216 tetramer interface [polypeptide binding]; other site 868595001217 catalytic Zn binding site [ion binding]; other site 868595001218 NADP binding site [chemical binding]; other site 868595001219 DsrE/DsrF-like family; Region: DrsE; cl00672 868595001220 EamA-like transporter family; Region: EamA; cl01037 868595001221 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 868595001222 EamA-like transporter family; Region: EamA; cl01037 868595001223 Transglycosylase; Region: Transgly; cl07896 868595001224 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 868595001225 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595001226 sporozoite surface protein 2 (SSP2); Provisional; Region: PTZ00441 868595001227 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 868595001228 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 868595001229 active site 868595001230 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 868595001231 putative deacylase active site [active] 868595001232 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 868595001233 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 868595001234 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595001235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001236 active site 868595001237 phosphorylation site [posttranslational modification] 868595001238 intermolecular recognition site; other site 868595001239 dimerization interface [polypeptide binding]; other site 868595001240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595001241 DNA binding site [nucleotide binding] 868595001242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595001243 dimerization interface [polypeptide binding]; other site 868595001244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595001245 dimer interface [polypeptide binding]; other site 868595001246 phosphorylation site [posttranslational modification] 868595001247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595001248 ATP binding site [chemical binding]; other site 868595001249 Mg2+ binding site [ion binding]; other site 868595001250 G-X-G motif; other site 868595001251 Domain of unknown function DUF302; Region: DUF302; cl01364 868595001252 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 868595001253 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 868595001254 metal-binding site [ion binding] 868595001255 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 868595001256 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 868595001257 metal-binding site [ion binding] 868595001258 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 868595001259 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 868595001260 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 868595001261 putative homotetramer interface [polypeptide binding]; other site 868595001262 putative homodimer interface [polypeptide binding]; other site 868595001263 allosteric switch controlling residues; other site 868595001264 putative metal binding site [ion binding]; other site 868595001265 putative homodimer-homodimer interface [polypeptide binding]; other site 868595001266 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 868595001267 AMP-binding enzyme; Region: AMP-binding; cl15778 868595001268 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 868595001269 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 868595001270 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 868595001271 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 868595001272 Walker A/P-loop; other site 868595001273 ATP binding site [chemical binding]; other site 868595001274 Q-loop/lid; other site 868595001275 ABC transporter signature motif; other site 868595001276 Walker B; other site 868595001277 D-loop; other site 868595001278 H-loop/switch region; other site 868595001279 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 868595001280 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 868595001281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001282 Walker A/P-loop; other site 868595001283 ATP binding site [chemical binding]; other site 868595001284 Q-loop/lid; other site 868595001285 ABC transporter signature motif; other site 868595001286 Walker B; other site 868595001287 D-loop; other site 868595001288 H-loop/switch region; other site 868595001289 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 868595001290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595001291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595001292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595001293 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 868595001294 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 868595001295 lipoyl synthase; Provisional; Region: PRK05481 868595001296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595001297 FeS/SAM binding site; other site 868595001298 hypothetical protein; Provisional; Region: PHA02992 868595001299 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 868595001300 dimer interface [polypeptide binding]; other site 868595001301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595001302 dimer interface [polypeptide binding]; other site 868595001303 conserved gate region; other site 868595001304 putative PBP binding loops; other site 868595001305 ABC-ATPase subunit interface; other site 868595001306 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 868595001307 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 868595001308 Walker A/P-loop; other site 868595001309 ATP binding site [chemical binding]; other site 868595001310 Q-loop/lid; other site 868595001311 ABC transporter signature motif; other site 868595001312 Walker B; other site 868595001313 D-loop; other site 868595001314 H-loop/switch region; other site 868595001315 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 868595001316 NMT1-like family; Region: NMT1_2; cl15260 868595001317 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 868595001318 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 868595001319 Helix-turn-helix domains; Region: HTH; cl00088 868595001320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 868595001321 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 868595001322 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 868595001323 putative active site [active] 868595001324 putative CoA binding site [chemical binding]; other site 868595001325 nudix motif; other site 868595001326 metal binding site [ion binding]; metal-binding site 868595001327 hybrid cluster protein; Provisional; Region: PRK05290 868595001328 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 868595001329 ACS interaction site; other site 868595001330 CODH interaction site; other site 868595001331 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 868595001332 hybrid metal cluster; other site 868595001333 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 868595001334 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 868595001335 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 868595001336 FAD binding pocket [chemical binding]; other site 868595001337 FAD binding motif [chemical binding]; other site 868595001338 phosphate binding motif [ion binding]; other site 868595001339 beta-alpha-beta structure motif; other site 868595001340 NAD binding pocket [chemical binding]; other site 868595001341 Iron coordination center [ion binding]; other site 868595001342 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 868595001343 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595001344 4Fe-4S binding domain; Region: Fer4; cl02805 868595001345 4Fe-4S binding domain; Region: Fer4; cl02805 868595001346 Bacitracin resistance protein BacA; Region: BacA; cl00858 868595001347 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 868595001348 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 868595001349 Domain of unknown function (DUF296); Region: DUF296; cl00720 868595001350 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 868595001351 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 868595001352 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 868595001353 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 868595001354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 868595001355 Helix-turn-helix domains; Region: HTH; cl00088 868595001356 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 868595001357 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 868595001358 Aspartase; Region: Aspartase; cd01357 868595001359 active sites [active] 868595001360 tetramer interface [polypeptide binding]; other site 868595001361 hydroxylamine reductase; Provisional; Region: PRK12310 868595001362 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 868595001363 cubane metal cluster [ion binding]; other site 868595001364 hybrid metal cluster; other site 868595001365 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 868595001366 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 868595001367 putative active site [active] 868595001368 metal binding site [ion binding]; metal-binding site 868595001369 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 868595001370 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 868595001371 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 868595001372 Walker A/P-loop; other site 868595001373 ATP binding site [chemical binding]; other site 868595001374 Q-loop/lid; other site 868595001375 ABC transporter signature motif; other site 868595001376 Walker B; other site 868595001377 D-loop; other site 868595001378 H-loop/switch region; other site 868595001379 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 868595001380 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595001381 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 868595001382 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 868595001383 TM-ABC transporter signature motif; other site 868595001384 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 868595001385 TM-ABC transporter signature motif; other site 868595001386 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 868595001387 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 868595001388 Walker A/P-loop; other site 868595001389 ATP binding site [chemical binding]; other site 868595001390 Q-loop/lid; other site 868595001391 ABC transporter signature motif; other site 868595001392 Walker B; other site 868595001393 D-loop; other site 868595001394 H-loop/switch region; other site 868595001395 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 868595001396 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 868595001397 Walker A/P-loop; other site 868595001398 ATP binding site [chemical binding]; other site 868595001399 Q-loop/lid; other site 868595001400 ABC transporter signature motif; other site 868595001401 Walker B; other site 868595001402 D-loop; other site 868595001403 H-loop/switch region; other site 868595001404 ferric uptake regulator; Provisional; Region: fur; PRK09462 868595001405 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 868595001406 metal binding site 2 [ion binding]; metal-binding site 868595001407 putative DNA binding helix; other site 868595001408 metal binding site 1 [ion binding]; metal-binding site 868595001409 dimer interface [polypeptide binding]; other site 868595001410 structural Zn2+ binding site [ion binding]; other site 868595001411 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 868595001412 Rubredoxin; Region: Rubredoxin; pfam00301 868595001413 iron binding site [ion binding]; other site 868595001414 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 868595001415 diiron binding motif [ion binding]; other site 868595001416 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 868595001417 octamerization interface [polypeptide binding]; other site 868595001418 diferric-oxygen binding site [ion binding]; other site 868595001419 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 868595001420 Chemotaxis phosphatase CheX; Region: CheX; cl15816 868595001421 HEAT repeats; Region: HEAT_2; pfam13646 868595001422 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 868595001423 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 868595001424 EamA-like transporter family; Region: EamA; cl01037 868595001425 EamA-like transporter family; Region: EamA; cl01037 868595001426 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 868595001427 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 868595001428 DNA binding site [nucleotide binding] 868595001429 active site 868595001430 S-layer homology domain; Region: SLH; pfam00395 868595001431 S-layer homology domain; Region: SLH; pfam00395 868595001432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 868595001433 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 868595001434 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 868595001435 FMN binding site [chemical binding]; other site 868595001436 substrate binding site [chemical binding]; other site 868595001437 putative catalytic residue [active] 868595001438 Cation transport protein; Region: TrkH; cl10514 868595001439 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 868595001440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595001441 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 868595001442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595001443 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 868595001444 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 868595001445 dimanganese center [ion binding]; other site 868595001446 CotJB protein; Region: CotJB; pfam12652 868595001447 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 868595001448 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 868595001449 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 868595001450 active site 868595001451 dimer interface [polypeptide binding]; other site 868595001452 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 868595001453 dimer interface [polypeptide binding]; other site 868595001454 active site 868595001455 Rhomboid family; Region: Rhomboid; cl11446 868595001456 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 868595001457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 868595001458 Coenzyme A binding pocket [chemical binding]; other site 868595001459 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 868595001460 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 868595001461 putative valine binding site [chemical binding]; other site 868595001462 dimer interface [polypeptide binding]; other site 868595001463 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 868595001464 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 868595001465 PemK-like protein; Region: PemK; cl00995 868595001466 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 868595001467 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 868595001468 catalytic triad [active] 868595001469 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 868595001470 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 868595001471 active site 868595001472 Response regulator receiver domain; Region: Response_reg; pfam00072 868595001473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001474 active site 868595001475 phosphorylation site [posttranslational modification] 868595001476 intermolecular recognition site; other site 868595001477 dimerization interface [polypeptide binding]; other site 868595001478 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 868595001479 thiamine phosphate binding site [chemical binding]; other site 868595001480 active site 868595001481 pyrophosphate binding site [ion binding]; other site 868595001482 ThiC family; Region: ThiC; cl08031 868595001483 thiamine monophosphate kinase; Provisional; Region: PRK05731 868595001484 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 868595001485 ATP binding site [chemical binding]; other site 868595001486 dimerization interface [polypeptide binding]; other site 868595001487 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 868595001488 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 868595001489 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 868595001490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 868595001491 Coenzyme A binding pocket [chemical binding]; other site 868595001492 UGMP family protein; Validated; Region: PRK09604 868595001493 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 868595001494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595001495 Radical SAM superfamily; Region: Radical_SAM; pfam04055 868595001496 FeS/SAM binding site; other site 868595001497 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 868595001498 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 868595001499 Protein of unknown function (DUF512); Region: DUF512; pfam04459 868595001500 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 868595001501 AMP-binding enzyme; Region: AMP-binding; cl15778 868595001502 ACT domain-containing protein [General function prediction only]; Region: COG4747 868595001503 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 868595001504 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 868595001505 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 868595001506 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 868595001507 Putative zinc-finger; Region: zf-HC2; cl15806 868595001508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595001509 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 868595001510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595001511 FeS/SAM binding site; other site 868595001512 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 868595001513 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 868595001514 dimer interface [polypeptide binding]; other site 868595001515 putative functional site; other site 868595001516 putative MPT binding site; other site 868595001517 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 868595001518 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 868595001519 dimer interface [polypeptide binding]; other site 868595001520 putative functional site; other site 868595001521 putative MPT binding site; other site 868595001522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 868595001523 Helix-turn-helix domains; Region: HTH; cl00088 868595001524 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 868595001525 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 868595001526 MPT binding site; other site 868595001527 trimer interface [polypeptide binding]; other site 868595001528 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 868595001529 oligomerisation interface [polypeptide binding]; other site 868595001530 mobile loop; other site 868595001531 roof hairpin; other site 868595001532 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 868595001533 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 868595001534 ring oligomerisation interface [polypeptide binding]; other site 868595001535 ATP/Mg binding site [chemical binding]; other site 868595001536 stacking interactions; other site 868595001537 hinge regions; other site 868595001538 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 868595001539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595001540 putative substrate translocation pore; other site 868595001541 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 868595001542 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 868595001543 dimer interface [polypeptide binding]; other site 868595001544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595001545 catalytic residue [active] 868595001546 acetyl-CoA synthetase; Provisional; Region: PRK00174 868595001547 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 868595001548 AMP-binding enzyme; Region: AMP-binding; cl15778 868595001549 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 868595001550 GAF domain; Region: GAF; cl15785 868595001551 Histidine kinase; Region: His_kinase; pfam06580 868595001552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595001553 ATP binding site [chemical binding]; other site 868595001554 Mg2+ binding site [ion binding]; other site 868595001555 G-X-G motif; other site 868595001556 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 868595001557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001558 active site 868595001559 phosphorylation site [posttranslational modification] 868595001560 intermolecular recognition site; other site 868595001561 dimerization interface [polypeptide binding]; other site 868595001562 LytTr DNA-binding domain; Region: LytTR; cl04498 868595001563 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 868595001564 putative carbohydrate kinase; Provisional; Region: PRK10565 868595001565 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 868595001566 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 868595001567 putative substrate binding site [chemical binding]; other site 868595001568 putative ATP binding site [chemical binding]; other site 868595001569 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 868595001570 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 868595001571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595001572 NAD(P) binding pocket [chemical binding]; other site 868595001573 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 868595001574 alanine racemase; Reviewed; Region: alr; PRK00053 868595001575 active site 868595001576 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 868595001577 dimer interface [polypeptide binding]; other site 868595001578 substrate binding site [chemical binding]; other site 868595001579 catalytic residues [active] 868595001580 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 868595001581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 868595001582 active site 868595001583 phosphorylation site [posttranslational modification] 868595001584 intermolecular recognition site; other site 868595001585 dimerization interface [polypeptide binding]; other site 868595001586 ANTAR domain; Region: ANTAR; cl04297 868595001587 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595001588 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595001589 active site 868595001590 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595001591 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 868595001592 active site 868595001593 metal binding site [ion binding]; metal-binding site 868595001594 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 868595001595 CHASE3 domain; Region: CHASE3; cl05000 868595001596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595001597 dimerization interface [polypeptide binding]; other site 868595001598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595001599 dimer interface [polypeptide binding]; other site 868595001600 putative CheW interface [polypeptide binding]; other site 868595001601 sensory histidine kinase AtoS; Provisional; Region: PRK11360 868595001602 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 868595001603 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595001604 Zn2+ binding site [ion binding]; other site 868595001605 Mg2+ binding site [ion binding]; other site 868595001606 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001607 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 868595001608 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 868595001609 catalytic residues [active] 868595001610 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 868595001611 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 868595001612 dimer interface [polypeptide binding]; other site 868595001613 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 868595001614 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 868595001615 putative active site [active] 868595001616 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595001617 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595001618 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 868595001619 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 868595001620 transmembrane helices; other site 868595001621 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 868595001622 active site 868595001623 homotetramer interface [polypeptide binding]; other site 868595001624 homodimer interface [polypeptide binding]; other site 868595001625 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 868595001626 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 868595001627 active site 868595001628 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 868595001629 hypothetical protein; Provisional; Region: PRK06851 868595001630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001631 Sodium:solute symporter family; Region: SSF; cl00456 868595001632 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 868595001633 Ligand Binding Site [chemical binding]; other site 868595001634 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 868595001635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595001636 dimer interface [polypeptide binding]; other site 868595001637 putative CheW interface [polypeptide binding]; other site 868595001638 Cache domain; Region: Cache_1; pfam02743 868595001639 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 868595001640 active site 868595001641 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 868595001642 dimer interface [polypeptide binding]; other site 868595001643 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 868595001644 Ligand Binding Site [chemical binding]; other site 868595001645 Molecular Tunnel; other site 868595001646 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 868595001647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001648 active site 868595001649 phosphorylation site [posttranslational modification] 868595001650 intermolecular recognition site; other site 868595001651 dimerization interface [polypeptide binding]; other site 868595001652 ANTAR domain; Region: ANTAR; cl04297 868595001653 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 868595001654 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 868595001655 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 868595001656 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 868595001657 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 868595001658 active site 868595001659 FMN binding site [chemical binding]; other site 868595001660 substrate binding site [chemical binding]; other site 868595001661 3Fe-4S cluster binding site [ion binding]; other site 868595001662 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 868595001663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001664 active site 868595001665 phosphorylation site [posttranslational modification] 868595001666 intermolecular recognition site; other site 868595001667 dimerization interface [polypeptide binding]; other site 868595001668 ANTAR domain; Region: ANTAR; cl04297 868595001669 glutamine synthetase, type I; Region: GlnA; TIGR00653 868595001670 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 868595001671 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 868595001672 glutamine synthetase, type I; Region: GlnA; TIGR00653 868595001673 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 868595001674 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 868595001675 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 868595001676 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 868595001677 active site 868595001678 dimer interface [polypeptide binding]; other site 868595001679 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 868595001680 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 868595001681 active site 868595001682 FMN binding site [chemical binding]; other site 868595001683 substrate binding site [chemical binding]; other site 868595001684 3Fe-4S cluster binding site [ion binding]; other site 868595001685 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 868595001686 domain interface; other site 868595001687 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 868595001688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595001689 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 868595001690 Nitrogen regulatory protein P-II; Region: P-II; cl00412 868595001691 Nitrogen regulatory protein P-II; Region: P-II; smart00938 868595001692 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 868595001693 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 868595001694 G1 box; other site 868595001695 GTP/Mg2+ binding site [chemical binding]; other site 868595001696 Switch I region; other site 868595001697 G2 box; other site 868595001698 Switch II region; other site 868595001699 G3 box; other site 868595001700 G4 box; other site 868595001701 G5 box; other site 868595001702 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 868595001703 Aspartase; Region: Aspartase; cd01357 868595001704 active sites [active] 868595001705 tetramer interface [polypeptide binding]; other site 868595001706 NAD synthetase; Provisional; Region: PRK13981 868595001707 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 868595001708 multimer interface [polypeptide binding]; other site 868595001709 active site 868595001710 catalytic triad [active] 868595001711 protein interface 1 [polypeptide binding]; other site 868595001712 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 868595001713 Ligand Binding Site [chemical binding]; other site 868595001714 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 868595001715 putative catalytic site [active] 868595001716 putative metal binding site [ion binding]; other site 868595001717 putative phosphate binding site [ion binding]; other site 868595001718 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595001719 putative peptidoglycan binding site; other site 868595001720 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595001721 putative peptidoglycan binding site; other site 868595001722 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595001723 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 868595001724 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 868595001725 dimer interface [polypeptide binding]; other site 868595001726 NAD binding site [chemical binding]; other site 868595001727 substrate binding site [chemical binding]; other site 868595001728 tetramer (dimer of dimers) interface [polypeptide binding]; other site 868595001729 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 868595001730 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 868595001731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001732 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 868595001733 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 868595001734 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 868595001735 CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863 868595001736 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 868595001737 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 868595001738 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 868595001739 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 868595001740 Helix-turn-helix domains; Region: HTH; cl00088 868595001741 Winged helix-turn helix; Region: HTH_29; pfam13551 868595001742 Integrase core domain; Region: rve; cl01316 868595001743 transposase; Provisional; Region: PRK06526 868595001744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595001745 Walker A motif; other site 868595001746 ATP binding site [chemical binding]; other site 868595001747 Walker B motif; other site 868595001748 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 868595001749 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 868595001750 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 868595001751 Cupin domain; Region: Cupin_2; cl09118 868595001752 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 868595001753 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 868595001754 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 868595001755 active site 868595001756 Sodium:solute symporter family; Region: SSF; cl00456 868595001757 Protein of unknown function (DUF502); Region: DUF502; cl01107 868595001758 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595001759 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 868595001760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001761 active site 868595001762 phosphorylation site [posttranslational modification] 868595001763 intermolecular recognition site; other site 868595001764 dimerization interface [polypeptide binding]; other site 868595001765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595001766 Walker A motif; other site 868595001767 ATP binding site [chemical binding]; other site 868595001768 Walker B motif; other site 868595001769 arginine finger; other site 868595001770 Helix-turn-helix domains; Region: HTH; cl00088 868595001771 sensory histidine kinase AtoS; Provisional; Region: PRK11360 868595001772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 868595001773 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 868595001774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595001775 dimer interface [polypeptide binding]; other site 868595001776 phosphorylation site [posttranslational modification] 868595001777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595001778 ATP binding site [chemical binding]; other site 868595001779 Mg2+ binding site [ion binding]; other site 868595001780 G-X-G motif; other site 868595001781 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 868595001782 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595001783 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 868595001784 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 868595001785 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 868595001786 PhoU domain; Region: PhoU; pfam01895 868595001787 PhoU domain; Region: PhoU; pfam01895 868595001788 Protein of unknown function DUF45; Region: DUF45; cl00636 868595001789 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 868595001790 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 868595001791 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595001792 putative peptidoglycan binding site; other site 868595001793 NlpC/P60 family; Region: NLPC_P60; cl11438 868595001794 S-layer homology domain; Region: SLH; pfam00395 868595001795 S-layer homology domain; Region: SLH; pfam00395 868595001796 Bacterial Ig-like domain; Region: Big_5; cl01012 868595001797 Sporulation and spore germination; Region: Germane; cl11253 868595001798 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 868595001799 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 868595001800 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 868595001801 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 868595001802 active site 868595001803 C-terminal domain interface [polypeptide binding]; other site 868595001804 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 868595001805 active site 868595001806 N-terminal domain interface [polypeptide binding]; other site 868595001807 Uncharacterized conserved protein [Function unknown]; Region: COG1739 868595001808 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 868595001809 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 868595001810 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 868595001811 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 868595001812 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 868595001813 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 868595001814 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 868595001815 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 868595001816 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 868595001817 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 868595001818 putative dimer interface [polypeptide binding]; other site 868595001819 active site pocket [active] 868595001820 putative cataytic base [active] 868595001821 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 868595001822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001823 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 868595001824 catalytic triad [active] 868595001825 CbiD; Region: CbiD; cl00828 868595001826 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 868595001827 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 868595001828 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 868595001829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595001830 S-adenosylmethionine binding site [chemical binding]; other site 868595001831 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 868595001832 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 868595001833 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 868595001834 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 868595001835 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 868595001836 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 868595001837 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 868595001838 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 868595001839 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 868595001840 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 868595001841 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 868595001842 putative active site [active] 868595001843 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 868595001844 Precorrin-8X methylmutase; Region: CbiC; pfam02570 868595001845 cobyric acid synthase; Provisional; Region: PRK00784 868595001846 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001847 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001848 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 868595001849 catalytic triad [active] 868595001850 CobD/Cbib protein; Region: CobD_Cbib; cl00561 868595001851 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 868595001852 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 868595001853 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 868595001854 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 868595001855 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595001856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595001857 homodimer interface [polypeptide binding]; other site 868595001858 catalytic residue [active] 868595001859 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 868595001860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595001861 ATP binding site [chemical binding]; other site 868595001862 putative Mg++ binding site [ion binding]; other site 868595001863 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 868595001864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595001865 nucleotide binding region [chemical binding]; other site 868595001866 ATP-binding site [chemical binding]; other site 868595001867 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 868595001868 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 868595001869 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 868595001870 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 868595001871 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 868595001872 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5...; Region: Glm_B12_BD; cd02072 868595001873 B12 binding site [chemical binding]; other site 868595001874 heterodimer interface [polypeptide binding]; other site 868595001875 cobalt ligand [ion binding]; other site 868595001876 MutL protein; Region: MutL; pfam13941 868595001877 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 868595001878 substrate binding site [chemical binding]; other site 868595001879 B12 cofactor binding site [chemical binding]; other site 868595001880 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 868595001881 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 868595001882 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 868595001883 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 868595001884 dimer interface [polypeptide binding]; other site 868595001885 active site 868595001886 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 868595001887 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 868595001888 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 868595001889 ribonuclease PH; Reviewed; Region: rph; PRK00173 868595001890 Ribonuclease PH; Region: RNase_PH_bact; cd11362 868595001891 hexamer interface [polypeptide binding]; other site 868595001892 active site 868595001893 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 868595001894 active site 868595001895 dimerization interface [polypeptide binding]; other site 868595001896 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 868595001897 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595001898 active site 868595001899 metal binding site [ion binding]; metal-binding site 868595001900 homotetramer interface [polypeptide binding]; other site 868595001901 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 868595001902 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001903 Family description; Region: UvrD_C_2; cl15862 868595001904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595001905 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595001906 putative substrate translocation pore; other site 868595001907 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 868595001908 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 868595001909 Helix-turn-helix domains; Region: HTH; cl00088 868595001910 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 868595001911 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 868595001912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 868595001913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595001914 dimer interface [polypeptide binding]; other site 868595001915 conserved gate region; other site 868595001916 putative PBP binding loops; other site 868595001917 ABC-ATPase subunit interface; other site 868595001918 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 868595001919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595001920 dimer interface [polypeptide binding]; other site 868595001921 conserved gate region; other site 868595001922 putative PBP binding loops; other site 868595001923 ABC-ATPase subunit interface; other site 868595001924 transposase; Provisional; Region: PRK06526 868595001925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595001926 Walker A motif; other site 868595001927 ATP binding site [chemical binding]; other site 868595001928 Walker B motif; other site 868595001929 Helix-turn-helix domains; Region: HTH; cl00088 868595001930 Winged helix-turn helix; Region: HTH_29; pfam13551 868595001931 Integrase core domain; Region: rve; cl01316 868595001932 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 868595001933 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 868595001934 Walker A/P-loop; other site 868595001935 ATP binding site [chemical binding]; other site 868595001936 Q-loop/lid; other site 868595001937 ABC transporter signature motif; other site 868595001938 Walker B; other site 868595001939 D-loop; other site 868595001940 H-loop/switch region; other site 868595001941 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 868595001942 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 868595001943 Uncharacterized conserved protein [Function unknown]; Region: COG3535 868595001944 Protein of unknown function (DUF917); Region: DUF917; pfam06032 868595001945 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 868595001946 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 868595001947 Membrane transport protein; Region: Mem_trans; cl09117 868595001948 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 868595001949 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001950 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001951 Family description; Region: UvrD_C_2; cl15862 868595001952 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595001953 ATP binding site [chemical binding]; other site 868595001954 putative Mg++ binding site [ion binding]; other site 868595001955 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595001956 nucleotide binding region [chemical binding]; other site 868595001957 ATP-binding site [chemical binding]; other site 868595001958 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 868595001959 Integrase core domain; Region: rve; cl01316 868595001960 Integrase core domain; Region: rve_3; cl15866 868595001961 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 868595001962 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 868595001963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595001964 Walker A motif; other site 868595001965 ATP binding site [chemical binding]; other site 868595001966 Walker B motif; other site 868595001967 arginine finger; other site 868595001968 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 868595001969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595001970 ATP binding site [chemical binding]; other site 868595001971 putative Mg++ binding site [ion binding]; other site 868595001972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595001973 nucleotide binding region [chemical binding]; other site 868595001974 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 868595001975 ATP-binding site [chemical binding]; other site 868595001976 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 868595001977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595001978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595001979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595001980 ATP binding site [chemical binding]; other site 868595001981 putative Mg++ binding site [ion binding]; other site 868595001982 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 868595001983 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 868595001984 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 868595001985 Integrase core domain; Region: rve; cl01316 868595001986 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 868595001987 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 868595001988 Helix-turn-helix domains; Region: HTH; cl00088 868595001989 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 868595001990 putative active site pocket [active] 868595001991 dimerization interface [polypeptide binding]; other site 868595001992 putative catalytic residue [active] 868595001993 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 868595001994 putative active site pocket [active] 868595001995 dimerization interface [polypeptide binding]; other site 868595001996 putative catalytic residue [active] 868595001997 SWIM zinc finger; Region: SWIM; cl15408 868595001998 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 868595001999 Protein of unknown function DUF262; Region: DUF262; cl14890 868595002000 Protein of unknown function DUF262; Region: DUF262; cl14890 868595002001 TIGR02300 family protein; Region: FYDLN_acid 868595002002 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 868595002003 metal ion-dependent adhesion site (MIDAS); other site 868595002004 Predicted transcriptional regulator [Transcription]; Region: COG2378 868595002005 Helix-turn-helix domains; Region: HTH; cl00088 868595002006 WYL domain; Region: WYL; cl14852 868595002007 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 868595002008 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 868595002009 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 868595002010 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 868595002011 zinc binding site [ion binding]; other site 868595002012 putative ligand binding site [chemical binding]; other site 868595002013 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 868595002014 TM-ABC transporter signature motif; other site 868595002015 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 868595002016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595002017 Walker A/P-loop; other site 868595002018 ATP binding site [chemical binding]; other site 868595002019 Q-loop/lid; other site 868595002020 ABC transporter signature motif; other site 868595002021 Walker B; other site 868595002022 D-loop; other site 868595002023 H-loop/switch region; other site 868595002024 GAF domain; Region: GAF; cl15785 868595002025 GAF domain; Region: GAF_2; pfam13185 868595002026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595002027 metal binding site [ion binding]; metal-binding site 868595002028 active site 868595002029 I-site; other site 868595002030 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595002031 Zn2+ binding site [ion binding]; other site 868595002032 Mg2+ binding site [ion binding]; other site 868595002033 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 868595002034 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 868595002035 active site 868595002036 metal binding site [ion binding]; metal-binding site 868595002037 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 868595002038 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 868595002039 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 868595002040 Domain of unknown function (DUF378); Region: DUF378; cl00943 868595002041 DsrE/DsrF-like family; Region: DrsE; cl00672 868595002042 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 868595002043 CPxP motif; other site 868595002044 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 868595002045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595002046 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 868595002047 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 868595002048 active site residue [active] 868595002049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595002050 dimerization interface [polypeptide binding]; other site 868595002051 putative DNA binding site [nucleotide binding]; other site 868595002052 putative Zn2+ binding site [ion binding]; other site 868595002053 SOS regulatory protein LexA; Region: lexA; TIGR00498 868595002054 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 868595002055 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 868595002056 active site 868595002057 metal binding site [ion binding]; metal-binding site 868595002058 DNA binding site [nucleotide binding] 868595002059 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 868595002060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595002061 Walker A/P-loop; other site 868595002062 ATP binding site [chemical binding]; other site 868595002063 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595002064 Q-loop/lid; other site 868595002065 ABC transporter signature motif; other site 868595002066 Walker B; other site 868595002067 D-loop; other site 868595002068 H-loop/switch region; other site 868595002069 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 868595002070 AzlC protein; Region: AzlC; cl00570 868595002071 trigger factor; Provisional; Region: tig; PRK01490 868595002072 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 868595002073 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 868595002074 Clp protease; Region: CLP_protease; pfam00574 868595002075 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 868595002076 oligomer interface [polypeptide binding]; other site 868595002077 active site residues [active] 868595002078 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 868595002079 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 868595002080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002081 Walker A motif; other site 868595002082 ATP binding site [chemical binding]; other site 868595002083 Walker B motif; other site 868595002084 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 868595002085 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 868595002086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002087 Walker A motif; other site 868595002088 ATP binding site [chemical binding]; other site 868595002089 Walker B motif; other site 868595002090 arginine finger; other site 868595002091 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 868595002092 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 868595002093 Found in ATP-dependent protease La (LON); Region: LON; smart00464 868595002094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002095 Walker A motif; other site 868595002096 ATP binding site [chemical binding]; other site 868595002097 Walker B motif; other site 868595002098 arginine finger; other site 868595002099 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 868595002100 Predicted GTPase [General function prediction only]; Region: COG0218 868595002101 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 868595002102 G1 box; other site 868595002103 GTP/Mg2+ binding site [chemical binding]; other site 868595002104 Switch I region; other site 868595002105 G2 box; other site 868595002106 G3 box; other site 868595002107 Switch II region; other site 868595002108 G4 box; other site 868595002109 G5 box; other site 868595002110 Spore germination protein; Region: Spore_permease; cl15802 868595002111 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 868595002112 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 868595002113 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 868595002114 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 868595002115 Spore germination protein; Region: Spore_permease; cl15802 868595002116 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 868595002117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002118 NMT1-like family; Region: NMT1_2; cl15260 868595002119 NMT1/THI5 like; Region: NMT1; pfam09084 868595002120 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 868595002121 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 868595002122 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 868595002123 HIGH motif; other site 868595002124 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 868595002125 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 868595002126 active site 868595002127 KMSKS motif; other site 868595002128 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 868595002129 tRNA binding surface [nucleotide binding]; other site 868595002130 anticodon binding site; other site 868595002131 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 868595002132 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 868595002133 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 868595002134 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595002135 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 868595002136 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 868595002137 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 868595002138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002139 Maf-like protein; Region: Maf; pfam02545 868595002140 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 868595002141 active site 868595002142 dimer interface [polypeptide binding]; other site 868595002143 hypothetical protein; Reviewed; Region: PRK00024 868595002144 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 868595002145 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 868595002146 MPN+ (JAMM) motif; other site 868595002147 Zinc-binding site [ion binding]; other site 868595002148 rod shape-determining protein MreB; Provisional; Region: PRK13927 868595002149 Cell division protein FtsA; Region: FtsA; cl11496 868595002150 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 868595002151 rod shape-determining protein MreC; Region: MreC; pfam04085 868595002152 rod shape-determining protein MreD; Region: MreD; cl01087 868595002153 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 868595002154 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 868595002155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595002156 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595002157 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 868595002158 septum site-determining protein MinD; Region: minD_bact; TIGR01968 868595002159 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 868595002160 Switch I; other site 868595002161 Switch II; other site 868595002162 Septum formation topological specificity factor MinE; Region: MinE; cl00538 868595002163 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 868595002164 Peptidase family M23; Region: Peptidase_M23; pfam01551 868595002165 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 868595002166 active site 868595002167 putative substrate binding region [chemical binding]; other site 868595002168 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 868595002169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595002170 FeS/SAM binding site; other site 868595002171 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 868595002172 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 868595002173 ribonuclease G; Provisional; Region: PRK11712 868595002174 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 868595002175 homodimer interface [polypeptide binding]; other site 868595002176 oligonucleotide binding site [chemical binding]; other site 868595002177 TRAM domain; Region: TRAM; cl01282 868595002178 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 868595002179 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 868595002180 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 868595002181 GTPase CgtA; Reviewed; Region: obgE; PRK12297 868595002182 GTP1/OBG; Region: GTP1_OBG; pfam01018 868595002183 Obg GTPase; Region: Obg; cd01898 868595002184 G1 box; other site 868595002185 GTP/Mg2+ binding site [chemical binding]; other site 868595002186 Switch I region; other site 868595002187 G2 box; other site 868595002188 G3 box; other site 868595002189 Switch II region; other site 868595002190 G4 box; other site 868595002191 G5 box; other site 868595002192 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 868595002193 Sugar fermentation stimulation protein; Region: SfsA; cl00647 868595002194 Flavin Reductases; Region: FlaRed; cl00801 868595002195 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 868595002196 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 868595002197 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 868595002198 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 868595002199 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 868595002200 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 868595002201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595002202 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 868595002203 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 868595002204 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 868595002205 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 868595002206 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 868595002207 transposase/IS protein; Provisional; Region: PRK09183 868595002208 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595002209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 868595002210 Integrase core domain; Region: rve; cl01316 868595002211 Helix-turn-helix domains; Region: HTH; cl00088 868595002212 Helix-turn-helix domains; Region: HTH; cl00088 868595002213 Integrase core domain; Region: rve; cl01316 868595002214 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 868595002215 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 868595002216 putative ligand binding site [chemical binding]; other site 868595002217 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 868595002218 TM-ABC transporter signature motif; other site 868595002219 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 868595002220 TM-ABC transporter signature motif; other site 868595002221 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 868595002222 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 868595002223 Walker A/P-loop; other site 868595002224 ATP binding site [chemical binding]; other site 868595002225 Q-loop/lid; other site 868595002226 ABC transporter signature motif; other site 868595002227 Walker B; other site 868595002228 D-loop; other site 868595002229 H-loop/switch region; other site 868595002230 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 868595002231 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 868595002232 Walker A/P-loop; other site 868595002233 ATP binding site [chemical binding]; other site 868595002234 Q-loop/lid; other site 868595002235 ABC transporter signature motif; other site 868595002236 Walker B; other site 868595002237 D-loop; other site 868595002238 H-loop/switch region; other site 868595002239 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 868595002240 alpha-gamma subunit interface [polypeptide binding]; other site 868595002241 beta-gamma subunit interface [polypeptide binding]; other site 868595002242 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 868595002243 gamma-beta subunit interface [polypeptide binding]; other site 868595002244 alpha-beta subunit interface [polypeptide binding]; other site 868595002245 urease subunit alpha; Reviewed; Region: ureC; PRK13207 868595002246 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 868595002247 subunit interactions [polypeptide binding]; other site 868595002248 active site 868595002249 flap region; other site 868595002250 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 868595002251 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 868595002252 dimer interface [polypeptide binding]; other site 868595002253 catalytic residues [active] 868595002254 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 868595002255 UreF; Region: UreF; pfam01730 868595002256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595002257 UreD urease accessory protein; Region: UreD; cl00530 868595002258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 868595002259 Transposase; Region: DEDD_Tnp_IS110; pfam01548 868595002260 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 868595002261 Helix-turn-helix domains; Region: HTH; cl00088 868595002262 Integrase core domain; Region: rve; cl01316 868595002263 Integrase core domain; Region: rve_3; cl15866 868595002264 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 868595002265 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 868595002266 Helix-turn-helix domains; Region: HTH; cl00088 868595002267 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 868595002268 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 868595002269 Helix-turn-helix domains; Region: HTH; cl00088 868595002270 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 868595002271 GntP family permease; Region: GntP_permease; pfam02447 868595002272 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 868595002273 Glycerate kinase family; Region: Gly_kinase; cl00841 868595002274 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 868595002275 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 868595002276 NAD binding site [chemical binding]; other site 868595002277 homodimer interface [polypeptide binding]; other site 868595002278 active site 868595002279 substrate binding site [chemical binding]; other site 868595002280 GtrA-like protein; Region: GtrA; cl00971 868595002281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595002282 dimerization interface [polypeptide binding]; other site 868595002283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595002284 dimer interface [polypeptide binding]; other site 868595002285 phosphorylation site [posttranslational modification] 868595002286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595002287 ATP binding site [chemical binding]; other site 868595002288 Mg2+ binding site [ion binding]; other site 868595002289 G-X-G motif; other site 868595002290 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595002291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595002292 active site 868595002293 phosphorylation site [posttranslational modification] 868595002294 intermolecular recognition site; other site 868595002295 dimerization interface [polypeptide binding]; other site 868595002296 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595002297 DNA binding site [nucleotide binding] 868595002298 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 868595002299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595002300 putative active site [active] 868595002301 heme pocket [chemical binding]; other site 868595002302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002303 Walker A motif; other site 868595002304 ATP binding site [chemical binding]; other site 868595002305 Walker B motif; other site 868595002306 arginine finger; other site 868595002307 Helix-turn-helix domains; Region: HTH; cl00088 868595002308 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 868595002309 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 868595002310 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 868595002311 tetramer interface [polypeptide binding]; other site 868595002312 TPP-binding site [chemical binding]; other site 868595002313 heterodimer interface [polypeptide binding]; other site 868595002314 phosphorylation loop region [posttranslational modification] 868595002315 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 868595002316 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 868595002317 alpha subunit interface [polypeptide binding]; other site 868595002318 TPP binding site [chemical binding]; other site 868595002319 heterodimer interface [polypeptide binding]; other site 868595002320 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 868595002321 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 868595002322 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 868595002323 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 868595002324 lipoyl synthase; Provisional; Region: PRK05481 868595002325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595002326 FeS/SAM binding site; other site 868595002327 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 868595002328 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 868595002329 E3 interaction surface; other site 868595002330 lipoyl attachment site [posttranslational modification]; other site 868595002331 e3 binding domain; Region: E3_binding; pfam02817 868595002332 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 868595002333 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 868595002334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 868595002335 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 868595002336 dimer interface [polypeptide binding]; other site 868595002337 active site 868595002338 metal binding site [ion binding]; metal-binding site 868595002339 glutathione binding site [chemical binding]; other site 868595002340 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 868595002341 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595002342 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 868595002343 intersubunit interface [polypeptide binding]; other site 868595002344 active site 868595002345 catalytic residue [active] 868595002346 H+ Antiporter protein; Region: 2A0121; TIGR00900 868595002347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595002348 putative substrate translocation pore; other site 868595002349 Peptidase family M48; Region: Peptidase_M48; cl12018 868595002350 Protein of unknown function (DUF503); Region: DUF503; cl00669 868595002351 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 868595002352 Uncharacterized conserved protein [Function unknown]; Region: COG2006 868595002353 4Fe-4S binding domain; Region: Fer4; cl02805 868595002354 4Fe-4S binding domain; Region: Fer4; cl02805 868595002355 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 868595002356 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 868595002357 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 868595002358 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 868595002359 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 868595002360 putative dimer interface [polypeptide binding]; other site 868595002361 putative anticodon binding site; other site 868595002362 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 868595002363 homodimer interface [polypeptide binding]; other site 868595002364 motif 1; other site 868595002365 motif 2; other site 868595002366 active site 868595002367 motif 3; other site 868595002368 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 868595002369 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 868595002370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595002371 FeS/SAM binding site; other site 868595002372 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 868595002373 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 868595002374 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 868595002375 Cation efflux family; Region: Cation_efflux; cl00316 868595002376 BON domain; Region: BON; cl02771 868595002377 BON domain; Region: BON; cl02771 868595002378 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 868595002379 metal binding site 2 [ion binding]; metal-binding site 868595002380 putative DNA binding helix; other site 868595002381 metal binding site 1 [ion binding]; metal-binding site 868595002382 dimer interface [polypeptide binding]; other site 868595002383 structural Zn2+ binding site [ion binding]; other site 868595002384 sensory histidine kinase AtoS; Provisional; Region: PRK11360 868595002385 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595002386 putative active site [active] 868595002387 heme pocket [chemical binding]; other site 868595002388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595002389 dimer interface [polypeptide binding]; other site 868595002390 phosphorylation site [posttranslational modification] 868595002391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595002392 ATP binding site [chemical binding]; other site 868595002393 Mg2+ binding site [ion binding]; other site 868595002394 G-X-G motif; other site 868595002395 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 868595002396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595002397 active site 868595002398 phosphorylation site [posttranslational modification] 868595002399 intermolecular recognition site; other site 868595002400 dimerization interface [polypeptide binding]; other site 868595002401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002402 Walker A motif; other site 868595002403 ATP binding site [chemical binding]; other site 868595002404 Walker B motif; other site 868595002405 Helix-turn-helix domains; Region: HTH; cl00088 868595002406 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 868595002407 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 868595002408 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 868595002409 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 868595002410 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 868595002411 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 868595002412 uracil transporter; Provisional; Region: PRK10720 868595002413 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 868595002414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595002415 active site 868595002416 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 868595002417 catalytic residues [active] 868595002418 Protein of unknown function (DUF552); Region: DUF552; cl00775 868595002419 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 868595002420 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 868595002421 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 868595002422 substrate binding site [chemical binding]; other site 868595002423 multimerization interface [polypeptide binding]; other site 868595002424 ATP binding site [chemical binding]; other site 868595002425 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 868595002426 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 868595002427 Cysteine-rich domain; Region: CCG; pfam02754 868595002428 Cysteine-rich domain; Region: CCG; pfam02754 868595002429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002430 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002431 4Fe-4S binding domain; Region: Fer4; cl02805 868595002432 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 868595002433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002435 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002436 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002438 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002439 4Fe-4S binding domain; Region: Fer4; cl02805 868595002440 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002442 4Fe-4S binding domain; Region: Fer4; cl02805 868595002443 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002445 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002446 4Fe-4S binding domain; Region: Fer4; cl02805 868595002447 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 868595002448 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 868595002449 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 868595002450 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 868595002451 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 868595002452 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595002453 Chromate transporter; Region: Chromate_transp; pfam02417 868595002454 Transcriptional regulators [Transcription]; Region: GntR; COG1802 868595002455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 868595002456 DNA-binding site [nucleotide binding]; DNA binding site 868595002457 FCD domain; Region: FCD; cl11656 868595002458 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 868595002459 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 868595002460 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 868595002461 Walker A motif; other site 868595002462 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 868595002463 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 868595002464 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 868595002465 P loop nucleotide binding; other site 868595002466 switch II; other site 868595002467 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 868595002468 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 868595002469 switch II; other site 868595002470 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 868595002471 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 868595002472 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 868595002473 dimerization interface [polypeptide binding]; other site 868595002474 domain crossover interface; other site 868595002475 redox-dependent activation switch; other site 868595002476 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 868595002477 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 868595002478 putative [4Fe-4S] binding site [ion binding]; other site 868595002479 putative molybdopterin cofactor binding site [chemical binding]; other site 868595002480 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 868595002481 molybdopterin cofactor binding site; other site 868595002482 hypothetical protein; Provisional; Region: PRK03636 868595002483 UPF0302 domain; Region: UPF0302; pfam08864 868595002484 IDEAL domain; Region: IDEAL; cl07452 868595002485 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 868595002486 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595002487 RNA binding surface [nucleotide binding]; other site 868595002488 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 868595002489 active site 868595002490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595002491 putative substrate translocation pore; other site 868595002492 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 868595002493 putative active site [active] 868595002494 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 868595002495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595002496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595002497 DNA binding residues [nucleotide binding] 868595002498 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 868595002499 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 868595002500 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 868595002501 Walker A/P-loop; other site 868595002502 ATP binding site [chemical binding]; other site 868595002503 Q-loop/lid; other site 868595002504 ABC transporter signature motif; other site 868595002505 Walker B; other site 868595002506 D-loop; other site 868595002507 H-loop/switch region; other site 868595002508 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595002509 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595002510 ABC-2 type transporter; Region: ABC2_membrane; cl11417 868595002511 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 868595002512 AAA domain; Region: AAA_32; pfam13654 868595002513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595002514 ATP-dependent protease Lon; Provisional; Region: PRK13765 868595002515 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 868595002516 Uncharacterized conserved protein [Function unknown]; Region: COG1284 868595002517 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 868595002518 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 868595002519 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 868595002520 Transposase domain (DUF772); Region: DUF772; cl15789 868595002521 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595002522 Transposase domain (DUF772); Region: DUF772; cl15789 868595002523 Transposase domain (DUF772); Region: DUF772; cl15789 868595002524 TIGR04076 family protein; Region: TIGR04076 868595002525 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 868595002526 4Fe-4S binding domain; Region: Fer4; cl02805 868595002527 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 868595002528 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 868595002529 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 868595002530 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 868595002531 VanW like protein; Region: VanW; pfam04294 868595002532 G5 domain; Region: G5; pfam07501 868595002533 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 868595002534 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 868595002535 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 868595002536 putative homodimer interface [polypeptide binding]; other site 868595002537 putative active site pocket [active] 868595002538 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 868595002539 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 868595002540 Cell division protein FtsA; Region: FtsA; cl11496 868595002541 Cell division protein FtsA; Region: FtsA; cl11496 868595002542 Ubiquitin-like proteins; Region: UBQ; cl00155 868595002543 charged pocket; other site 868595002544 hydrophobic patch; other site 868595002545 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 868595002546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 868595002547 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 868595002548 Transposase domain (DUF772); Region: DUF772; cl15789 868595002549 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595002550 Transposase domain (DUF772); Region: DUF772; cl15789 868595002551 Transposase domain (DUF772); Region: DUF772; cl15789 868595002552 FAD binding domain; Region: FAD_binding_4; pfam01565 868595002553 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 868595002554 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 868595002555 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595002556 Cysteine-rich domain; Region: CCG; pfam02754 868595002557 Cysteine-rich domain; Region: CCG; pfam02754 868595002558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 868595002559 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 868595002560 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595002561 dimer interface [polypeptide binding]; other site 868595002562 putative CheW interface [polypeptide binding]; other site 868595002563 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 868595002564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595002565 active site 868595002566 phosphorylation site [posttranslational modification] 868595002567 intermolecular recognition site; other site 868595002568 dimerization interface [polypeptide binding]; other site 868595002569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595002570 DNA binding site [nucleotide binding] 868595002571 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 868595002572 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 868595002573 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 868595002574 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 868595002575 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 868595002576 Walker A/P-loop; other site 868595002577 ATP binding site [chemical binding]; other site 868595002578 Q-loop/lid; other site 868595002579 ABC transporter signature motif; other site 868595002580 Walker B; other site 868595002581 D-loop; other site 868595002582 H-loop/switch region; other site 868595002583 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 868595002584 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 868595002585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595002586 dimer interface [polypeptide binding]; other site 868595002587 conserved gate region; other site 868595002588 putative PBP binding loops; other site 868595002589 ABC-ATPase subunit interface; other site 868595002590 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 868595002591 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 868595002592 substrate binding pocket [chemical binding]; other site 868595002593 membrane-bound complex binding site; other site 868595002594 hinge residues; other site 868595002595 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 868595002596 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 868595002597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595002598 catalytic residue [active] 868595002599 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 868595002600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595002601 active site 868595002602 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 868595002603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595002604 S-adenosylmethionine binding site [chemical binding]; other site 868595002605 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 868595002606 Probable Catalytic site; other site 868595002607 metal-binding site 868595002608 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 868595002609 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 868595002610 substrate binding site; other site 868595002611 metal-binding site 868595002612 Oligomer interface; other site 868595002613 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 868595002614 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595002615 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 868595002616 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595002617 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 868595002618 Probable Catalytic site; other site 868595002619 metal-binding site 868595002620 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595002621 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 868595002622 Probable Catalytic site; other site 868595002623 metal-binding site 868595002624 Cupin domain; Region: Cupin_2; cl09118 868595002625 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 868595002626 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 868595002627 NADP binding site [chemical binding]; other site 868595002628 active site 868595002629 putative substrate binding site [chemical binding]; other site 868595002630 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 868595002631 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 868595002632 NAD binding site [chemical binding]; other site 868595002633 substrate binding site [chemical binding]; other site 868595002634 homodimer interface [polypeptide binding]; other site 868595002635 active site 868595002636 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 868595002637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595002638 S-adenosylmethionine binding site [chemical binding]; other site 868595002639 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 868595002640 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595002641 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 868595002642 Probable Catalytic site; other site 868595002643 metal-binding site 868595002644 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 868595002645 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 868595002646 putative metal binding site; other site 868595002647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002648 binding surface 868595002649 TPR motif; other site 868595002650 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 868595002651 putative metal binding site; other site 868595002652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002653 binding surface 868595002654 TPR motif; other site 868595002655 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 868595002656 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 868595002657 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 868595002658 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595002659 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 868595002660 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595002661 active site 868595002662 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 868595002663 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 868595002664 putative metal binding site; other site 868595002665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002666 TPR motif; other site 868595002667 binding surface 868595002668 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 868595002669 putative metal binding site; other site 868595002670 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 868595002671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002672 binding surface 868595002673 TPR motif; other site 868595002674 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 868595002675 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 868595002676 putative metal binding site; other site 868595002677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002678 binding surface 868595002679 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 868595002680 TPR motif; other site 868595002681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002682 TPR motif; other site 868595002683 binding surface 868595002684 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 868595002685 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 868595002686 YmaF family; Region: YmaF; pfam12788 868595002687 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 868595002688 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 868595002689 homodimer interface [polypeptide binding]; other site 868595002690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595002691 catalytic residue [active] 868595002692 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 868595002693 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 868595002694 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 868595002695 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 868595002696 Family description; Region: UvrD_C_2; cl15862 868595002697 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 868595002698 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 868595002699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002700 Walker A motif; other site 868595002701 ATP binding site [chemical binding]; other site 868595002702 Walker B motif; other site 868595002703 arginine finger; other site 868595002704 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 868595002705 metal ion-dependent adhesion site (MIDAS); other site 868595002706 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595002707 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 868595002708 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 868595002709 recombination factor protein RarA; Reviewed; Region: PRK13342 868595002710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002711 Walker A motif; other site 868595002712 ATP binding site [chemical binding]; other site 868595002713 Walker B motif; other site 868595002714 arginine finger; other site 868595002715 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 868595002716 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 868595002717 heme-binding site [chemical binding]; other site 868595002718 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595002719 dimer interface [polypeptide binding]; other site 868595002720 putative CheW interface [polypeptide binding]; other site 868595002721 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 868595002722 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 868595002723 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 868595002724 ABC transporter; Region: ABC_tran_2; pfam12848 868595002725 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 868595002726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595002727 S-adenosylmethionine binding site [chemical binding]; other site 868595002728 Ion channel; Region: Ion_trans_2; cl11596 868595002729 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 868595002730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002731 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 868595002732 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 868595002733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595002734 dimerization interface [polypeptide binding]; other site 868595002735 putative DNA binding site [nucleotide binding]; other site 868595002736 putative Zn2+ binding site [ion binding]; other site 868595002737 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 868595002738 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 868595002739 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595002740 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 868595002741 Probable Catalytic site; other site 868595002742 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 868595002743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 868595002744 Probable transposase; Region: OrfB_IS605; pfam01385 868595002745 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 868595002746 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 868595002747 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 868595002748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595002749 FeS/SAM binding site; other site 868595002750 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 868595002751 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 868595002752 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 868595002753 active site residue [active] 868595002754 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 868595002755 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 868595002756 GIY-YIG motif/motif A; other site 868595002757 putative active site [active] 868595002758 putative metal binding site [ion binding]; other site 868595002759 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 868595002760 flavoprotein, HI0933 family; Region: TIGR00275 868595002761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002762 Predicted membrane protein [Function unknown]; Region: COG4129 868595002763 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 868595002764 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 868595002765 4Fe-4S binding domain; Region: Fer4; cl02805 868595002766 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595002767 Polysulphide reductase, NrfD; Region: NrfD; cl01295 868595002768 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 868595002769 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 868595002770 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595002771 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595002772 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595002773 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 868595002774 Helix-turn-helix domains; Region: HTH; cl00088 868595002775 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 868595002776 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 868595002777 putative dimerization interface [polypeptide binding]; other site 868595002778 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 868595002779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595002780 S-adenosylmethionine binding site [chemical binding]; other site 868595002781 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 868595002782 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595002783 Cysteine-rich domain; Region: CCG; pfam02754 868595002784 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 868595002785 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 868595002786 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 868595002787 catalytic residue [active] 868595002788 putative FPP diphosphate binding site; other site 868595002789 putative FPP binding hydrophobic cleft; other site 868595002790 dimer interface [polypeptide binding]; other site 868595002791 putative IPP diphosphate binding site; other site 868595002792 glycogen branching enzyme; Provisional; Region: PRK12313 868595002793 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 868595002794 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 868595002795 active site 868595002796 catalytic site [active] 868595002797 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 868595002798 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 868595002799 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 868595002800 ligand binding site; other site 868595002801 oligomer interface; other site 868595002802 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 868595002803 N-terminal domain interface [polypeptide binding]; other site 868595002804 sulfate 1 binding site; other site 868595002805 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 868595002806 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 868595002807 ligand binding site; other site 868595002808 oligomer interface; other site 868595002809 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 868595002810 dimer interface [polypeptide binding]; other site 868595002811 N-terminal domain interface [polypeptide binding]; other site 868595002812 sulfate 1 binding site; other site 868595002813 glycogen synthase; Provisional; Region: glgA; PRK00654 868595002814 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 868595002815 ADP-binding pocket [chemical binding]; other site 868595002816 homodimer interface [polypeptide binding]; other site 868595002817 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 868595002818 homodimer interface [polypeptide binding]; other site 868595002819 maltodextrin glucosidase; Provisional; Region: PRK10785 868595002820 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 868595002821 active site 868595002822 homodimer interface [polypeptide binding]; other site 868595002823 catalytic site [active] 868595002824 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 868595002825 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 868595002826 benzoate transport; Region: 2A0115; TIGR00895 868595002827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595002828 putative substrate translocation pore; other site 868595002829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595002830 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 868595002831 NeuB family; Region: NeuB; cl00496 868595002832 prephenate dehydratase; Provisional; Region: PRK11898 868595002833 Prephenate dehydratase; Region: PDT; pfam00800 868595002834 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 868595002835 putative L-Phe binding site [chemical binding]; other site 868595002836 Chorismate mutase type II; Region: CM_2; cl00693 868595002837 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 868595002838 SpoVA protein; Region: SpoVA; cl04298 868595002839 stage V sporulation protein AD; Provisional; Region: PRK12404 868595002840 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 868595002841 SpoVA protein; Region: SpoVA; cl04298 868595002842 Protein of unknown function (DUF421); Region: DUF421; cl00990 868595002843 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 868595002844 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 868595002845 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 868595002846 Protein of unknown function (DUF421); Region: DUF421; cl00990 868595002847 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 868595002848 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 868595002849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595002850 active site 868595002851 phosphorylation site [posttranslational modification] 868595002852 intermolecular recognition site; other site 868595002853 dimerization interface [polypeptide binding]; other site 868595002854 LytTr DNA-binding domain; Region: LytTR; cl04498 868595002855 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 868595002856 Carbon starvation protein CstA; Region: CstA; pfam02554 868595002857 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 868595002858 heat shock protein 90; Provisional; Region: PRK05218 868595002859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 868595002860 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 868595002861 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 868595002862 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 868595002863 ligand binding site [chemical binding]; other site 868595002864 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 868595002865 putative ADP-ribose binding site [chemical binding]; other site 868595002866 putative active site [active] 868595002867 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 868595002868 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595002869 DRTGG domain; Region: DRTGG; cl12147 868595002870 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595002871 DHH family; Region: DHH; pfam01368 868595002872 DHHA2 domain; Region: DHHA2; pfam02833 868595002873 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 868595002874 thiosulfate reductase PhsA; Provisional; Region: PRK15488 868595002875 putative [Fe4-S4] binding site [ion binding]; other site 868595002876 putative molybdopterin cofactor binding site [chemical binding]; other site 868595002877 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 868595002878 putative molybdopterin cofactor binding site; other site 868595002879 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 868595002880 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 868595002881 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 868595002882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002883 hydrogenase 4 subunit H; Validated; Region: PRK08222 868595002884 4Fe-4S binding domain; Region: Fer4; cl02805 868595002885 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 868595002886 transaminase; Validated; Region: PRK07324 868595002887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595002888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595002889 homodimer interface [polypeptide binding]; other site 868595002890 catalytic residue [active] 868595002891 YkyB-like protein; Region: YkyB; pfam14177 868595002892 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 868595002893 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 868595002894 dimerization interface 3.5A [polypeptide binding]; other site 868595002895 active site 868595002896 NAD-dependent deacetylase; Provisional; Region: PRK00481 868595002897 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 868595002898 YwiC-like protein; Region: YwiC; pfam14256 868595002899 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 868595002900 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 868595002901 active site 868595002902 FMN binding site [chemical binding]; other site 868595002903 substrate binding site [chemical binding]; other site 868595002904 homotetramer interface [polypeptide binding]; other site 868595002905 catalytic residue [active] 868595002906 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595002907 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 868595002908 sensory histidine kinase AtoS; Provisional; Region: PRK11360 868595002909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595002910 dimerization interface [polypeptide binding]; other site 868595002911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595002912 dimer interface [polypeptide binding]; other site 868595002913 phosphorylation site [posttranslational modification] 868595002914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595002915 ATP binding site [chemical binding]; other site 868595002916 Mg2+ binding site [ion binding]; other site 868595002917 G-X-G motif; other site 868595002918 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 868595002919 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 868595002920 Acetokinase family; Region: Acetate_kinase; cl01029 868595002921 FIST N domain; Region: FIST; cl10701 868595002922 FIST C domain; Region: FIST_C; pfam10442 868595002923 Helix-turn-helix domains; Region: HTH; cl00088 868595002924 Winged helix-turn helix; Region: HTH_29; pfam13551 868595002925 Integrase core domain; Region: rve; cl01316 868595002926 transposase; Provisional; Region: PRK06526 868595002927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002928 Walker A motif; other site 868595002929 ATP binding site [chemical binding]; other site 868595002930 Walker B motif; other site 868595002931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002932 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 868595002933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595002934 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 868595002935 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 868595002936 Predicted permeases [General function prediction only]; Region: COG0701 868595002937 Predicted permease; Region: DUF318; pfam03773 868595002938 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 868595002939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595002940 FeS/SAM binding site; other site 868595002941 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 868595002942 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 868595002943 Membrane transport protein; Region: Mem_trans; cl09117 868595002944 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595002945 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595002946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595002947 putative DNA binding site [nucleotide binding]; other site 868595002948 dimerization interface [polypeptide binding]; other site 868595002949 putative Zn2+ binding site [ion binding]; other site 868595002950 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 868595002951 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595002952 active site 868595002953 metal binding site [ion binding]; metal-binding site 868595002954 homotetramer interface [polypeptide binding]; other site 868595002955 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595002956 dimerization interface [polypeptide binding]; other site 868595002957 putative DNA binding site [nucleotide binding]; other site 868595002958 putative Zn2+ binding site [ion binding]; other site 868595002959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595002960 dimerization interface [polypeptide binding]; other site 868595002961 putative DNA binding site [nucleotide binding]; other site 868595002962 putative Zn2+ binding site [ion binding]; other site 868595002963 Methyltransferase domain; Region: Methyltransf_31; pfam13847 868595002964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595002965 S-adenosylmethionine binding site [chemical binding]; other site 868595002966 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 868595002967 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595002968 4Fe-4S binding domain; Region: Fer4; cl02805 868595002969 4Fe-4S binding domain; Region: Fer4; cl02805 868595002970 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 868595002971 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 868595002972 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595002973 4Fe-4S binding domain; Region: Fer4; cl02805 868595002974 4Fe-4S binding domain; Region: Fer4; cl02805 868595002975 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595002976 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 868595002977 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 868595002978 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595002979 catalytic loop [active] 868595002980 iron binding site [ion binding]; other site 868595002981 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 868595002982 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 868595002983 [4Fe-4S] binding site [ion binding]; other site 868595002984 molybdopterin cofactor binding site; other site 868595002985 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 868595002986 molybdopterin cofactor binding site; other site 868595002987 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 868595002988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595002989 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595002990 4Fe-4S binding domain; Region: Fer4; cl02805 868595002991 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595002992 Putative Fe-S cluster; Region: FeS; pfam04060 868595002993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 868595002994 PAS domain; Region: PAS_9; pfam13426 868595002995 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 868595002996 N-acetyl-D-glucosamine binding site [chemical binding]; other site 868595002997 catalytic residue [active] 868595002998 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 868595002999 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 868595003000 CoA-binding site [chemical binding]; other site 868595003001 ATP-binding [chemical binding]; other site 868595003002 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 868595003003 Domain of unknown function DUF; Region: DUF204; pfam02659 868595003004 Domain of unknown function DUF; Region: DUF204; pfam02659 868595003005 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 868595003006 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 868595003007 DNA binding site [nucleotide binding] 868595003008 catalytic residue [active] 868595003009 H2TH interface [polypeptide binding]; other site 868595003010 putative catalytic residues [active] 868595003011 turnover-facilitating residue; other site 868595003012 intercalation triad [nucleotide binding]; other site 868595003013 8OG recognition residue [nucleotide binding]; other site 868595003014 putative reading head residues; other site 868595003015 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 868595003016 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 868595003017 DNA polymerase I; Provisional; Region: PRK05755 868595003018 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 868595003019 active site 868595003020 metal binding site 1 [ion binding]; metal-binding site 868595003021 putative 5' ssDNA interaction site; other site 868595003022 metal binding site 3; metal-binding site 868595003023 metal binding site 2 [ion binding]; metal-binding site 868595003024 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 868595003025 putative DNA binding site [nucleotide binding]; other site 868595003026 putative metal binding site [ion binding]; other site 868595003027 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 868595003028 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 868595003029 active site 868595003030 DNA binding site [nucleotide binding] 868595003031 catalytic site [active] 868595003032 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 868595003033 C-terminal peptidase (prc); Region: prc; TIGR00225 868595003034 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 868595003035 protein binding site [polypeptide binding]; other site 868595003036 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 868595003037 Catalytic dyad [active] 868595003038 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595003039 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 868595003040 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 868595003041 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 868595003042 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 868595003043 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 868595003044 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595003045 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 868595003046 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595003047 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595003048 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595003049 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595003050 DNA binding residues [nucleotide binding] 868595003051 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595003052 catalytic residues [active] 868595003053 catalytic nucleophile [active] 868595003054 YtxC-like family; Region: YtxC; cl08500 868595003055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 868595003056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 868595003057 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 868595003058 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 868595003059 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 868595003060 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 868595003061 active site 868595003062 dimer interface [polypeptide binding]; other site 868595003063 motif 1; other site 868595003064 motif 2; other site 868595003065 motif 3; other site 868595003066 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 868595003067 anticodon binding site; other site 868595003068 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 868595003069 NMT1-like family; Region: NMT1_2; cl15260 868595003070 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 868595003071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595003072 dimer interface [polypeptide binding]; other site 868595003073 conserved gate region; other site 868595003074 putative PBP binding loops; other site 868595003075 ABC-ATPase subunit interface; other site 868595003076 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 868595003077 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 868595003078 Walker A/P-loop; other site 868595003079 ATP binding site [chemical binding]; other site 868595003080 Q-loop/lid; other site 868595003081 ABC transporter signature motif; other site 868595003082 Walker B; other site 868595003083 D-loop; other site 868595003084 H-loop/switch region; other site 868595003085 Arginase family; Region: Arginase; cl00306 868595003086 High-affinity nickel-transport protein; Region: NicO; cl00964 868595003087 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 868595003088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 868595003089 substrate binding pocket [chemical binding]; other site 868595003090 membrane-bound complex binding site; other site 868595003091 hinge residues; other site 868595003092 Isochorismatase family; Region: Isochorismatase; pfam00857 868595003093 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 868595003094 catalytic triad [active] 868595003095 conserved cis-peptide bond; other site 868595003096 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 868595003097 NMT1-like family; Region: NMT1_2; cl15260 868595003098 Arginase family; Region: Arginase; cl00306 868595003099 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 868595003100 Transposase domain (DUF772); Region: DUF772; cl15789 868595003101 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595003102 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 868595003103 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 868595003104 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 868595003105 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 868595003106 ribosomal protein L20; Region: rpl20; CHL00068 868595003107 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 868595003108 23S rRNA binding site [nucleotide binding]; other site 868595003109 L21 binding site [polypeptide binding]; other site 868595003110 L13 binding site [polypeptide binding]; other site 868595003111 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 868595003112 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 868595003113 Propanediol utilisation protein PduL; Region: PduL; pfam06130 868595003114 Propanediol utilisation protein PduL; Region: PduL; pfam06130 868595003115 Acetokinase family; Region: Acetate_kinase; cl01029 868595003116 propionate/acetate kinase; Provisional; Region: PRK12379 868595003117 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 868595003118 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 868595003119 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 868595003120 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 868595003121 metal-binding site [ion binding] 868595003122 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 868595003123 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 868595003124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595003125 dimerization interface [polypeptide binding]; other site 868595003126 putative DNA binding site [nucleotide binding]; other site 868595003127 putative Zn2+ binding site [ion binding]; other site 868595003128 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 868595003129 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 868595003130 catalytic motif [active] 868595003131 Zn binding site [ion binding]; other site 868595003132 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 868595003133 Lumazine binding domain; Region: Lum_binding; pfam00677 868595003134 Lumazine binding domain; Region: Lum_binding; pfam00677 868595003135 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 868595003136 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 868595003137 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 868595003138 dimerization interface [polypeptide binding]; other site 868595003139 active site 868595003140 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 868595003141 homopentamer interface [polypeptide binding]; other site 868595003142 active site 868595003143 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 868595003144 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 868595003145 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 868595003146 generic binding surface II; other site 868595003147 ssDNA binding site; other site 868595003148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595003149 ATP binding site [chemical binding]; other site 868595003150 putative Mg++ binding site [ion binding]; other site 868595003151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595003152 nucleotide binding region [chemical binding]; other site 868595003153 ATP-binding site [chemical binding]; other site 868595003154 Germination protease; Region: Peptidase_A25; cl04057 868595003155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595003156 S-adenosylmethionine binding site [chemical binding]; other site 868595003157 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 868595003158 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 868595003159 active site 868595003160 (T/H)XGH motif; other site 868595003161 Plant ATP synthase F0; Region: YMF19; cl07975 868595003162 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 868595003163 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595003164 DRTGG domain; Region: DRTGG; cl12147 868595003165 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 868595003166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595003167 CoA-ligase; Region: Ligase_CoA; cl02894 868595003168 ATP-grasp domain; Region: ATP-grasp_4; cl03087 868595003169 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 868595003170 Nucleoside recognition; Region: Gate; cl00486 868595003171 Nucleoside recognition; Region: Gate; cl00486 868595003172 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 868595003173 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 868595003174 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 868595003175 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 868595003176 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 868595003177 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 868595003178 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 868595003179 dimer interface [polypeptide binding]; other site 868595003180 active site 868595003181 CoA binding pocket [chemical binding]; other site 868595003182 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 868595003183 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 868595003184 FMN binding site [chemical binding]; other site 868595003185 substrate binding site [chemical binding]; other site 868595003186 putative catalytic residue [active] 868595003187 Acyl transferase domain; Region: Acyl_transf_1; cl08282 868595003188 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 868595003189 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 868595003190 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 868595003191 NAD(P) binding site [chemical binding]; other site 868595003192 homotetramer interface [polypeptide binding]; other site 868595003193 homodimer interface [polypeptide binding]; other site 868595003194 active site 868595003195 Phosphopantetheine attachment site; Region: PP-binding; cl09936 868595003196 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 868595003197 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 868595003198 dimer interface [polypeptide binding]; other site 868595003199 active site 868595003200 ribonuclease III; Reviewed; Region: rnc; PRK00102 868595003201 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 868595003202 dimerization interface [polypeptide binding]; other site 868595003203 active site 868595003204 metal binding site [ion binding]; metal-binding site 868595003205 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 868595003206 dsRNA binding site [nucleotide binding]; other site 868595003207 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 868595003208 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 868595003209 Walker A/P-loop; other site 868595003210 ATP binding site [chemical binding]; other site 868595003211 Q-loop/lid; other site 868595003212 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 868595003213 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 868595003214 ABC transporter signature motif; other site 868595003215 Walker B; other site 868595003216 D-loop; other site 868595003217 H-loop/switch region; other site 868595003218 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 868595003219 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 868595003220 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 868595003221 P loop; other site 868595003222 GTP binding site [chemical binding]; other site 868595003223 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 868595003224 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 868595003225 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 868595003226 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 868595003227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595003228 oligomerization interface [polypeptide binding]; other site 868595003229 active site 868595003230 NAD+ binding site [chemical binding]; other site 868595003231 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 868595003232 intersubunit interface [polypeptide binding]; other site 868595003233 active site 868595003234 Zn2+ binding site [ion binding]; other site 868595003235 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 868595003236 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 868595003237 active site 868595003238 putative substrate binding pocket [chemical binding]; other site 868595003239 PUA domain; Region: PUA; cl00607 868595003240 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 868595003241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595003242 S-adenosylmethionine binding site [chemical binding]; other site 868595003243 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 868595003244 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 868595003245 inhibitor-cofactor binding pocket; inhibition site 868595003246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595003247 catalytic residue [active] 868595003248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595003249 DNA binding residues [nucleotide binding] 868595003250 signal recognition particle protein; Provisional; Region: PRK10867 868595003251 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 868595003252 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 868595003253 P loop; other site 868595003254 GTP binding site [chemical binding]; other site 868595003255 Signal peptide binding domain; Region: SRP_SPB; pfam02978 868595003256 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 868595003257 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 868595003258 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 868595003259 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 868595003260 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 868595003261 RimM N-terminal domain; Region: RimM; pfam01782 868595003262 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 868595003263 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 868595003264 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 868595003265 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 868595003266 Catalytic site [active] 868595003267 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 868595003268 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 868595003269 GTP/Mg2+ binding site [chemical binding]; other site 868595003270 G4 box; other site 868595003271 G5 box; other site 868595003272 G1 box; other site 868595003273 Switch I region; other site 868595003274 G2 box; other site 868595003275 G3 box; other site 868595003276 Switch II region; other site 868595003277 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 868595003278 RNA/DNA hybrid binding site [nucleotide binding]; other site 868595003279 active site 868595003280 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 868595003281 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 868595003282 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 868595003283 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 868595003284 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 868595003285 NADH dehydrogenase; Region: NADHdh; cl00469 868595003286 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 868595003287 4Fe-4S binding domain; Region: Fer4; cl02805 868595003288 4Fe-4S binding domain; Region: Fer4; cl02805 868595003289 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 868595003290 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 868595003291 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 868595003292 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 868595003293 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 868595003294 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 868595003295 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 868595003296 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 868595003297 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 868595003298 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 868595003299 Restriction endonuclease; Region: Mrr_cat; cl00516 868595003300 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 868595003301 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 868595003302 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595003303 MULE transposase domain; Region: MULE; pfam10551 868595003304 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595003305 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 868595003306 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 868595003307 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 868595003308 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 868595003309 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595003310 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 868595003311 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 868595003312 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 868595003313 Helix-turn-helix domains; Region: HTH; cl00088 868595003314 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 868595003315 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 868595003316 Nucleotide-binding sites [chemical binding]; other site 868595003317 Walker A motif; other site 868595003318 Switch I region of nucleotide binding site; other site 868595003319 Fe4S4 binding sites [ion binding]; other site 868595003320 Switch II region of nucleotide binding site; other site 868595003321 Nitrogen regulatory protein P-II; Region: P-II; cl00412 868595003322 Nitrogen regulatory protein P-II; Region: P-II; smart00938 868595003323 Nitrogen regulatory protein P-II; Region: P-II; cl00412 868595003324 Nitrogen regulatory protein P-II; Region: P-II; smart00938 868595003325 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 868595003326 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 868595003327 MoFe protein alpha/beta subunit interactions; other site 868595003328 Alpha subunit P cluster binding residues; other site 868595003329 FeMoco binding residues [chemical binding]; other site 868595003330 MoFe protein alpha subunit/Fe protein contacts; other site 868595003331 MoFe protein dimer/ dimer interactions; other site 868595003332 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 868595003333 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 868595003334 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 868595003335 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 868595003336 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 868595003337 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 868595003338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595003339 Radical SAM superfamily; Region: Radical_SAM; pfam04055 868595003340 FeS/SAM binding site; other site 868595003341 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582 868595003342 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 868595003343 active site 868595003344 catalytic residues [active] 868595003345 metal binding site [ion binding]; metal-binding site 868595003346 Protein of unknown function (DUF523); Region: DUF523; cl00733 868595003347 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 868595003348 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 868595003349 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 868595003350 P-loop; other site 868595003351 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595003352 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 868595003353 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 868595003354 ACS interaction site; other site 868595003355 CODH interaction site; other site 868595003356 cubane metal cluster (B-cluster) [ion binding]; other site 868595003357 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 868595003358 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 868595003359 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 868595003360 ligand binding site [chemical binding]; other site 868595003361 flexible hinge region; other site 868595003362 Helix-turn-helix domains; Region: HTH; cl00088 868595003363 putative switch regulator; other site 868595003364 non-specific DNA interactions [nucleotide binding]; other site 868595003365 DNA binding site [nucleotide binding] 868595003366 sequence specific DNA binding site [nucleotide binding]; other site 868595003367 putative cAMP binding site [chemical binding]; other site 868595003368 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 868595003369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595003370 Walker A motif; other site 868595003371 ATP binding site [chemical binding]; other site 868595003372 Walker B motif; other site 868595003373 arginine finger; other site 868595003374 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595003375 MULE transposase domain; Region: MULE; pfam10551 868595003376 Protein of unknown function (DUF456); Region: DUF456; cl01069 868595003377 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595003378 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 868595003379 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 868595003380 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 868595003381 catalytic triad [active] 868595003382 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 868595003383 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 868595003384 Uncharacterized conserved protein [Function unknown]; Region: COG2718 868595003385 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 868595003386 SpoVR like protein; Region: SpoVR; pfam04293 868595003387 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 868595003388 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 868595003389 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 868595003390 putative DNA binding site [nucleotide binding]; other site 868595003391 putative homodimer interface [polypeptide binding]; other site 868595003392 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 868595003393 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 868595003394 active site 868595003395 DNA binding site [nucleotide binding] 868595003396 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 868595003397 DNA binding site [nucleotide binding] 868595003398 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 868595003399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595003400 active site 868595003401 phosphorylation site [posttranslational modification] 868595003402 intermolecular recognition site; other site 868595003403 dimerization interface [polypeptide binding]; other site 868595003404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595003405 Walker A motif; other site 868595003406 ATP binding site [chemical binding]; other site 868595003407 Walker B motif; other site 868595003408 arginine finger; other site 868595003409 Helix-turn-helix domains; Region: HTH; cl00088 868595003410 sensory histidine kinase AtoS; Provisional; Region: PRK11360 868595003411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 868595003412 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 868595003413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595003414 dimer interface [polypeptide binding]; other site 868595003415 phosphorylation site [posttranslational modification] 868595003416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595003417 ATP binding site [chemical binding]; other site 868595003418 Mg2+ binding site [ion binding]; other site 868595003419 G-X-G motif; other site 868595003420 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595003421 Helix-turn-helix domains; Region: HTH; cl00088 868595003422 WYL domain; Region: WYL; cl14852 868595003423 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 868595003424 Sulfate transporter family; Region: Sulfate_transp; cl15842 868595003425 Sulfate transporter family; Region: Sulfate_transp; cl15842 868595003426 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 868595003427 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 868595003428 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 868595003429 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 868595003430 transmembrane helices; other site 868595003431 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 868595003432 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 868595003433 transmembrane helices; other site 868595003434 Helix-turn-helix domains; Region: HTH; cl00088 868595003435 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 868595003436 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595003437 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 868595003438 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 868595003439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595003440 dimerization interface [polypeptide binding]; other site 868595003441 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 868595003442 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 868595003443 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 868595003444 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 868595003445 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 868595003446 ATP binding site [chemical binding]; other site 868595003447 Walker A motif; other site 868595003448 hexamer interface [polypeptide binding]; other site 868595003449 Walker B motif; other site 868595003450 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 868595003451 TadE-like protein; Region: TadE; cl10688 868595003452 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 868595003453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 868595003454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595003455 active site 868595003456 phosphorylation site [posttranslational modification] 868595003457 intermolecular recognition site; other site 868595003458 dimerization interface [polypeptide binding]; other site 868595003459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 868595003460 DNA binding residues [nucleotide binding] 868595003461 dimerization interface [polypeptide binding]; other site 868595003462 Sensor protein DegS; Region: DegS; pfam05384 868595003463 Histidine kinase; Region: HisKA_3; pfam07730 868595003464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595003465 ATP binding site [chemical binding]; other site 868595003466 Mg2+ binding site [ion binding]; other site 868595003467 G-X-G motif; other site 868595003468 histidinol-phosphatase; Provisional; Region: PRK07328 868595003469 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 868595003470 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 868595003471 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595003472 putative peptidoglycan binding site; other site 868595003473 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595003474 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 868595003475 Transglycosylase; Region: Transgly; cl07896 868595003476 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 868595003477 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595003478 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 868595003479 Cation transport protein; Region: TrkH; cl10514 868595003480 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 868595003481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595003482 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 868595003483 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 868595003484 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 868595003485 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 868595003486 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 868595003487 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 868595003488 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 868595003489 dimer interface [polypeptide binding]; other site 868595003490 motif 1; other site 868595003491 active site 868595003492 motif 2; other site 868595003493 motif 3; other site 868595003494 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 868595003495 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 868595003496 putative tRNA-binding site [nucleotide binding]; other site 868595003497 B3/4 domain; Region: B3_4; cl11458 868595003498 tRNA synthetase B5 domain; Region: B5; cl08394 868595003499 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 868595003500 dimer interface [polypeptide binding]; other site 868595003501 motif 1; other site 868595003502 motif 3; other site 868595003503 motif 2; other site 868595003504 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 868595003505 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 868595003506 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 868595003507 thiamine phosphate binding site [chemical binding]; other site 868595003508 active site 868595003509 pyrophosphate binding site [ion binding]; other site 868595003510 Cell division protein ZapA; Region: ZapA; cl01146 868595003511 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 868595003512 hypothetical protein; Provisional; Region: PRK08609 868595003513 active site 868595003514 primer binding site [nucleotide binding]; other site 868595003515 NTP binding site [chemical binding]; other site 868595003516 metal binding triad [ion binding]; metal-binding site 868595003517 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 868595003518 active site 868595003519 DNA binding site [nucleotide binding] 868595003520 Uncharacterized conserved protein [Function unknown]; Region: COG0327 868595003521 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 868595003522 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 868595003523 Peptidase family U32; Region: Peptidase_U32; cl03113 868595003524 Collagenase; Region: DUF3656; pfam12392 868595003525 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 868595003526 Peptidase family U32; Region: Peptidase_U32; cl03113 868595003527 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 868595003528 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 868595003529 Walker A/P-loop; other site 868595003530 ATP binding site [chemical binding]; other site 868595003531 Q-loop/lid; other site 868595003532 ABC transporter signature motif; other site 868595003533 Walker B; other site 868595003534 D-loop; other site 868595003535 H-loop/switch region; other site 868595003536 Smr domain; Region: Smr; cl02619 868595003537 Peptidase family M48; Region: Peptidase_M48; cl12018 868595003538 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 868595003539 E-class dimer interface [polypeptide binding]; other site 868595003540 P-class dimer interface [polypeptide binding]; other site 868595003541 active site 868595003542 Cu2+ binding site [ion binding]; other site 868595003543 Zn2+ binding site [ion binding]; other site 868595003544 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 868595003545 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 868595003546 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 868595003547 Family description; Region: VCBS; pfam13517 868595003548 Transglycosylase; Region: Transgly; cl07896 868595003549 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 868595003550 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595003551 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 868595003552 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 868595003553 active site 868595003554 HIGH motif; other site 868595003555 dimer interface [polypeptide binding]; other site 868595003556 KMSKS motif; other site 868595003557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595003558 RNA binding surface [nucleotide binding]; other site 868595003559 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 868595003560 Flagellin N-methylase; Region: FliB; cl00497 868595003561 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595003562 catalytic loop [active] 868595003563 iron binding site [ion binding]; other site 868595003564 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 868595003565 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595003566 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595003567 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 868595003568 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 868595003569 dimer interface [polypeptide binding]; other site 868595003570 [2Fe-2S] cluster binding site [ion binding]; other site 868595003571 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 868595003572 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 868595003573 SLBB domain; Region: SLBB; pfam10531 868595003574 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 868595003575 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 868595003576 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 868595003577 putative dimer interface [polypeptide binding]; other site 868595003578 [2Fe-2S] cluster binding site [ion binding]; other site 868595003579 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 868595003580 Helix-turn-helix domains; Region: HTH; cl00088 868595003581 Integrase core domain; Region: rve; cl01316 868595003582 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595003583 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 868595003584 catalytic loop [active] 868595003585 iron binding site [ion binding]; other site 868595003586 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 868595003587 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595003588 4Fe-4S binding domain; Region: Fer4; cl02805 868595003589 4Fe-4S binding domain; Region: Fer4; cl02805 868595003590 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595003591 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 868595003592 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 868595003593 dimer interface [polypeptide binding]; other site 868595003594 [2Fe-2S] cluster binding site [ion binding]; other site 868595003595 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 868595003596 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 868595003597 SLBB domain; Region: SLBB; pfam10531 868595003598 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 868595003599 4Fe-4S binding domain; Region: Fer4; cl02805 868595003600 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 868595003601 4Fe-4S binding domain; Region: Fer4; cl02805 868595003602 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 868595003603 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 868595003604 putative dimer interface [polypeptide binding]; other site 868595003605 [2Fe-2S] cluster binding site [ion binding]; other site 868595003606 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595003607 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 868595003608 NAD synthase; Region: NAD_synthase; pfam02540 868595003609 homodimer interface [polypeptide binding]; other site 868595003610 NAD binding pocket [chemical binding]; other site 868595003611 ATP binding pocket [chemical binding]; other site 868595003612 Mg binding site [ion binding]; other site 868595003613 active-site loop [active] 868595003614 Transcriptional regulator; Region: Transcrip_reg; cl00361 868595003615 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 868595003616 active site 868595003617 putative DNA-binding cleft [nucleotide binding]; other site 868595003618 dimer interface [polypeptide binding]; other site 868595003619 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 868595003620 RuvA N terminal domain; Region: RuvA_N; pfam01330 868595003621 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 868595003622 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 868595003623 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 868595003624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595003625 Walker A motif; other site 868595003626 ATP binding site [chemical binding]; other site 868595003627 Walker B motif; other site 868595003628 arginine finger; other site 868595003629 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 868595003630 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595003631 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 868595003632 Ligand Binding Site [chemical binding]; other site 868595003633 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 868595003634 Stage II sporulation protein; Region: SpoIID; pfam08486 868595003635 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 868595003636 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 868595003637 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 868595003638 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 868595003639 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 868595003640 Preprotein translocase subunit; Region: YajC; cl00806 868595003641 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595003642 Zn2+ binding site [ion binding]; other site 868595003643 Mg2+ binding site [ion binding]; other site 868595003644 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 868595003645 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 868595003646 Protein export membrane protein; Region: SecD_SecF; cl14618 868595003647 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 868595003648 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 868595003649 Protein export membrane protein; Region: SecD_SecF; cl14618 868595003650 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 868595003651 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 868595003652 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 868595003653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595003654 RNA binding surface [nucleotide binding]; other site 868595003655 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 868595003656 active site 868595003657 Protein of unknown function (DUF441); Region: DUF441; cl01041 868595003658 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595003659 putative peptidoglycan binding site; other site 868595003660 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595003661 putative peptidoglycan binding site; other site 868595003662 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595003663 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 868595003664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595003665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595003666 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 868595003667 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595003668 active site 868595003669 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 868595003670 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 868595003671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595003672 dihydroorotase; Validated; Region: pyrC; PRK09357 868595003673 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 868595003674 active site 868595003675 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 868595003676 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 868595003677 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 868595003678 catalytic site [active] 868595003679 subunit interface [polypeptide binding]; other site 868595003680 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 868595003681 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 868595003682 ATP-grasp domain; Region: ATP-grasp_4; cl03087 868595003683 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 868595003684 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 868595003685 ATP-grasp domain; Region: ATP-grasp_4; cl03087 868595003686 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 868595003687 IMP binding site; other site 868595003688 dimer interface [polypeptide binding]; other site 868595003689 interdomain contacts; other site 868595003690 partial ornithine binding site; other site 868595003691 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 868595003692 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 868595003693 FAD binding pocket [chemical binding]; other site 868595003694 FAD binding motif [chemical binding]; other site 868595003695 phosphate binding motif [ion binding]; other site 868595003696 beta-alpha-beta structure motif; other site 868595003697 NAD binding pocket [chemical binding]; other site 868595003698 Iron coordination center [ion binding]; other site 868595003699 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 868595003700 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 868595003701 heterodimer interface [polypeptide binding]; other site 868595003702 active site 868595003703 FMN binding site [chemical binding]; other site 868595003704 homodimer interface [polypeptide binding]; other site 868595003705 substrate binding site [chemical binding]; other site 868595003706 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 868595003707 active site 868595003708 dimer interface [polypeptide binding]; other site 868595003709 lipoprotein signal peptidase; Provisional; Region: PRK14787 868595003710 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 868595003711 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 868595003712 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595003713 active site 868595003714 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 868595003715 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 868595003716 Domain of unknown function (DUF814); Region: DUF814; pfam05670 868595003717 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 868595003718 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 868595003719 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 868595003720 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 868595003721 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 868595003722 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 868595003723 CHASE3 domain; Region: CHASE3; cl05000 868595003724 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 868595003725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595003726 dimerization interface [polypeptide binding]; other site 868595003727 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595003728 dimer interface [polypeptide binding]; other site 868595003729 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 868595003730 putative CheW interface [polypeptide binding]; other site 868595003731 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 868595003732 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 868595003733 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 868595003734 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 868595003735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595003736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595003737 homodimer interface [polypeptide binding]; other site 868595003738 catalytic residue [active] 868595003739 aspartate aminotransferase; Provisional; Region: PRK05764 868595003740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595003741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595003742 homodimer interface [polypeptide binding]; other site 868595003743 catalytic residue [active] 868595003744 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 868595003745 hypothetical protein; Provisional; Region: PRK11820 868595003746 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 868595003747 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 868595003748 Domain of unknown function (DUF370); Region: DUF370; cl00898 868595003749 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 868595003750 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 868595003751 catalytic site [active] 868595003752 G-X2-G-X-G-K; other site 868595003753 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 868595003754 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 868595003755 Flavoprotein; Region: Flavoprotein; cl08021 868595003756 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 868595003757 primosome assembly protein PriA; Validated; Region: PRK05580 868595003758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595003759 ATP binding site [chemical binding]; other site 868595003760 putative Mg++ binding site [ion binding]; other site 868595003761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595003762 ATP-binding site [chemical binding]; other site 868595003763 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 868595003764 active site 868595003765 catalytic residues [active] 868595003766 metal binding site [ion binding]; metal-binding site 868595003767 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 868595003768 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 868595003769 putative active site [active] 868595003770 substrate binding site [chemical binding]; other site 868595003771 putative cosubstrate binding site; other site 868595003772 catalytic site [active] 868595003773 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 868595003774 substrate binding site [chemical binding]; other site 868595003775 Protein of unknown function DUF116; Region: DUF116; cl00800 868595003776 16S rRNA methyltransferase B; Provisional; Region: PRK14902 868595003777 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 868595003778 putative RNA binding site [nucleotide binding]; other site 868595003779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595003780 S-adenosylmethionine binding site [chemical binding]; other site 868595003781 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 868595003782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595003783 FeS/SAM binding site; other site 868595003784 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 868595003785 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 868595003786 phosphopeptide binding site; other site 868595003787 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 868595003788 phosphopeptide binding site; other site 868595003789 Protein phosphatase 2C; Region: PP2C; pfam00481 868595003790 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 868595003791 active site 868595003792 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 868595003793 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595003794 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 868595003795 Catalytic domain of Protein Kinases; Region: PKc; cd00180 868595003796 active site 868595003797 ATP binding site [chemical binding]; other site 868595003798 substrate binding site [chemical binding]; other site 868595003799 activation loop (A-loop); other site 868595003800 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 868595003801 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 868595003802 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 868595003803 GTPase RsgA; Reviewed; Region: PRK00098 868595003804 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 868595003805 RNA binding site [nucleotide binding]; other site 868595003806 homodimer interface [polypeptide binding]; other site 868595003807 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 868595003808 GTPase/Zn-binding domain interface [polypeptide binding]; other site 868595003809 GTP/Mg2+ binding site [chemical binding]; other site 868595003810 G4 box; other site 868595003811 G5 box; other site 868595003812 G1 box; other site 868595003813 Switch I region; other site 868595003814 G2 box; other site 868595003815 G3 box; other site 868595003816 Switch II region; other site 868595003817 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 868595003818 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 868595003819 substrate binding site [chemical binding]; other site 868595003820 hexamer interface [polypeptide binding]; other site 868595003821 metal binding site [ion binding]; metal-binding site 868595003822 adenylate kinase; Reviewed; Region: adk; PRK00279 868595003823 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 868595003824 AMP-binding site [chemical binding]; other site 868595003825 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 868595003826 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 868595003827 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 868595003828 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 868595003829 putative ligand binding site [chemical binding]; other site 868595003830 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 868595003831 TM-ABC transporter signature motif; other site 868595003832 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 868595003833 TM-ABC transporter signature motif; other site 868595003834 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 868595003835 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 868595003836 Walker A/P-loop; other site 868595003837 ATP binding site [chemical binding]; other site 868595003838 Q-loop/lid; other site 868595003839 ABC transporter signature motif; other site 868595003840 Walker B; other site 868595003841 D-loop; other site 868595003842 H-loop/switch region; other site 868595003843 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 868595003844 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 868595003845 Walker A/P-loop; other site 868595003846 ATP binding site [chemical binding]; other site 868595003847 Q-loop/lid; other site 868595003848 ABC transporter signature motif; other site 868595003849 Walker B; other site 868595003850 D-loop; other site 868595003851 H-loop/switch region; other site 868595003852 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 868595003853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595003854 Walker A motif; other site 868595003855 ATP binding site [chemical binding]; other site 868595003856 Walker B motif; other site 868595003857 arginine finger; other site 868595003858 Helix-turn-helix domains; Region: HTH; cl00088 868595003859 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 868595003860 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 868595003861 putative ligand binding site [chemical binding]; other site 868595003862 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 868595003863 TM-ABC transporter signature motif; other site 868595003864 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 868595003865 TM-ABC transporter signature motif; other site 868595003866 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 868595003867 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 868595003868 Walker A/P-loop; other site 868595003869 ATP binding site [chemical binding]; other site 868595003870 Q-loop/lid; other site 868595003871 ABC transporter signature motif; other site 868595003872 Walker B; other site 868595003873 D-loop; other site 868595003874 H-loop/switch region; other site 868595003875 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 868595003876 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 868595003877 Walker A/P-loop; other site 868595003878 ATP binding site [chemical binding]; other site 868595003879 Q-loop/lid; other site 868595003880 ABC transporter signature motif; other site 868595003881 Walker B; other site 868595003882 D-loop; other site 868595003883 H-loop/switch region; other site 868595003884 FOG: CBS domain [General function prediction only]; Region: COG0517 868595003885 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595003886 PAS domain S-box; Region: sensory_box; TIGR00229 868595003887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 868595003888 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 868595003889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595003890 Walker A motif; other site 868595003891 ATP binding site [chemical binding]; other site 868595003892 Walker B motif; other site 868595003893 arginine finger; other site 868595003894 Helix-turn-helix domains; Region: HTH; cl00088 868595003895 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 868595003896 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 868595003897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595003898 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 868595003899 4Fe-4S binding domain; Region: Fer4; cl02805 868595003900 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 868595003901 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 868595003902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595003903 hypothetical protein; Provisional; Region: PRK09898 868595003904 4Fe-4S binding domain; Region: Fer4; cl02805 868595003905 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 868595003906 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 868595003907 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 868595003908 Ubiquitin-like proteins; Region: UBQ; cl00155 868595003909 charged pocket; other site 868595003910 hydrophobic patch; other site 868595003911 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 868595003912 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595003913 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 868595003914 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 868595003915 dimer interface [polypeptide binding]; other site 868595003916 PYR/PP interface [polypeptide binding]; other site 868595003917 TPP binding site [chemical binding]; other site 868595003918 substrate binding site [chemical binding]; other site 868595003919 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 868595003920 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 868595003921 TPP-binding site [chemical binding]; other site 868595003922 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 868595003923 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 868595003924 Spore germination protein; Region: Spore_permease; cl15802 868595003925 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 868595003926 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 868595003927 RQC domain; Region: RQC; cl09632 868595003928 HEAT repeats; Region: HEAT_2; pfam13646 868595003929 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 868595003930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595003931 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595003932 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 868595003933 ATP-grasp domain; Region: ATP-grasp_4; cl03087 868595003934 CoA-ligase; Region: Ligase_CoA; cl02894 868595003935 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 868595003936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595003937 CoA-ligase; Region: Ligase_CoA; cl02894 868595003938 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 868595003939 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 868595003940 active site 868595003941 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 868595003942 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 868595003943 active site 868595003944 substrate binding site [chemical binding]; other site 868595003945 catalytic site [active] 868595003946 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595003947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595003948 nucleotide binding region [chemical binding]; other site 868595003949 ATP-binding site [chemical binding]; other site 868595003950 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 868595003951 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 868595003952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595003953 dimer interface [polypeptide binding]; other site 868595003954 phosphorylation site [posttranslational modification] 868595003955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595003956 ATP binding site [chemical binding]; other site 868595003957 Mg2+ binding site [ion binding]; other site 868595003958 G-X-G motif; other site 868595003959 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 868595003960 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 868595003961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595003962 FeS/SAM binding site; other site 868595003963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595003964 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 868595003965 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 868595003966 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 868595003967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595003968 binding surface 868595003969 TPR motif; other site 868595003970 TPR repeat; Region: TPR_11; pfam13414 868595003971 TPR repeat; Region: TPR_11; pfam13414 868595003972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595003973 binding surface 868595003974 TPR motif; other site 868595003975 TPR repeat; Region: TPR_11; pfam13414 868595003976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595003977 binding surface 868595003978 TPR motif; other site 868595003979 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 868595003980 active site 868595003981 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 868595003982 Ligand Binding Site [chemical binding]; other site 868595003983 Domain of unknown function (DUF366); Region: DUF366; cl00890 868595003984 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 868595003985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595003986 FeS/SAM binding site; other site 868595003987 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 868595003988 homodecamer interface [polypeptide binding]; other site 868595003989 GTP cyclohydrolase I; Provisional; Region: PLN03044 868595003990 active site 868595003991 putative catalytic site residues [active] 868595003992 zinc binding site [ion binding]; other site 868595003993 GTP-CH-I/GFRP interaction surface; other site 868595003994 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 868595003995 Survival protein SurE; Region: SurE; cl00448 868595003996 stage V sporulation protein B; Region: spore_V_B; TIGR02900 868595003997 MatE; Region: MatE; cl10513 868595003998 MatE; Region: MatE; cl10513 868595003999 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 868595004000 elongation factor G; Reviewed; Region: PRK12740 868595004001 G1 box; other site 868595004002 putative GEF interaction site [polypeptide binding]; other site 868595004003 GTP/Mg2+ binding site [chemical binding]; other site 868595004004 Switch I region; other site 868595004005 G2 box; other site 868595004006 G3 box; other site 868595004007 Switch II region; other site 868595004008 G4 box; other site 868595004009 G5 box; other site 868595004010 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 868595004011 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 868595004012 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 868595004013 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 868595004014 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 868595004015 4Fe-4S binding domain; Region: Fer4; cl02805 868595004016 4Fe-4S binding domain; Region: Fer4; cl02805 868595004017 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595004018 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 868595004019 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 868595004020 ATP-grasp domain; Region: ATP-grasp_4; cl03087 868595004021 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 868595004022 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 868595004023 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 868595004024 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 868595004025 active site 868595004026 ADP/pyrophosphate binding site [chemical binding]; other site 868595004027 dimerization interface [polypeptide binding]; other site 868595004028 allosteric effector site; other site 868595004029 fructose-1,6-bisphosphate binding site; other site 868595004030 Late competence development protein ComFB; Region: ComFB; pfam10719 868595004031 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595004032 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 868595004033 putative ADP-binding pocket [chemical binding]; other site 868595004034 GatB domain; Region: GatB_Yqey; cl11497 868595004035 Protein of unknown function DUF89; Region: DUF89; cl15397 868595004036 Spore germination protein; Region: Spore_permease; cl15802 868595004037 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 868595004038 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 868595004039 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 868595004040 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 868595004041 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 868595004042 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 868595004043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004044 Walker A motif; other site 868595004045 ATP binding site [chemical binding]; other site 868595004046 Walker B motif; other site 868595004047 arginine finger; other site 868595004048 Helix-turn-helix domains; Region: HTH; cl00088 868595004049 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 868595004050 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 868595004051 catalytic residue [active] 868595004052 VanZ like family; Region: VanZ; cl01971 868595004053 FOG: CBS domain [General function prediction only]; Region: COG0517 868595004054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 868595004055 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 868595004056 4Fe-4S binding domain; Region: Fer4; cl02805 868595004057 iron-sulfur cluster binding protein, putative; Region: TIGR00276 868595004058 Carbon starvation protein CstA; Region: CstA; pfam02554 868595004059 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 868595004060 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 868595004061 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 868595004062 Potassium binding sites [ion binding]; other site 868595004063 Cesium cation binding sites [ion binding]; other site 868595004064 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 868595004065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004066 FeS/SAM binding site; other site 868595004067 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595004068 Zn2+ binding site [ion binding]; other site 868595004069 Mg2+ binding site [ion binding]; other site 868595004070 Protein of unknown function (DUF342); Region: DUF342; pfam03961 868595004071 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595004072 MULE transposase domain; Region: MULE; pfam10551 868595004073 malate dehydrogenase; Reviewed; Region: PRK06223 868595004074 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 868595004075 NAD(P) binding site [chemical binding]; other site 868595004076 dimer interface [polypeptide binding]; other site 868595004077 tetramer (dimer of dimers) interface [polypeptide binding]; other site 868595004078 substrate binding site [chemical binding]; other site 868595004079 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 868595004080 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 868595004081 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 868595004082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004083 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 868595004084 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 868595004085 Iron-sulfur protein interface; other site 868595004086 proximal heme binding site [chemical binding]; other site 868595004087 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 868595004088 Fumarase C-terminus; Region: Fumerase_C; cl00795 868595004089 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 868595004090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 868595004091 PAS fold; Region: PAS_4; pfam08448 868595004092 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 868595004093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004094 ATP binding site [chemical binding]; other site 868595004095 Walker B motif; other site 868595004096 arginine finger; other site 868595004097 Helix-turn-helix domains; Region: HTH; cl00088 868595004098 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 868595004099 Transposase; Region: DEDD_Tnp_IS110; pfam01548 868595004100 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 868595004101 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 868595004102 LexA repressor; Validated; Region: PRK00215 868595004103 Helix-turn-helix domains; Region: HTH; cl00088 868595004104 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 868595004105 Catalytic site [active] 868595004106 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 868595004107 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 868595004108 DNA binding residues [nucleotide binding] 868595004109 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 868595004110 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 868595004111 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 868595004112 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 868595004113 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 868595004114 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 868595004115 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 868595004116 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 868595004117 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 868595004118 catalytic residue [active] 868595004119 stage V sporulation protein K; Region: spore_V_K; TIGR02881 868595004120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004121 Walker A motif; other site 868595004122 ATP binding site [chemical binding]; other site 868595004123 Walker B motif; other site 868595004124 arginine finger; other site 868595004125 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 868595004126 Sm1 motif; other site 868595004127 intra - hexamer interaction site; other site 868595004128 inter - hexamer interaction site [polypeptide binding]; other site 868595004129 nucleotide binding pocket [chemical binding]; other site 868595004130 Sm2 motif; other site 868595004131 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595004132 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 868595004133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004134 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 868595004135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004136 ATP binding site [chemical binding]; other site 868595004137 Mg2+ binding site [ion binding]; other site 868595004138 G-X-G motif; other site 868595004139 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 868595004140 ATP binding site [chemical binding]; other site 868595004141 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 868595004142 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 868595004143 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 868595004144 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 868595004145 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 868595004146 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 868595004147 MutS domain I; Region: MutS_I; pfam01624 868595004148 MutS domain II; Region: MutS_II; pfam05188 868595004149 MutS family domain IV; Region: MutS_IV; pfam05190 868595004150 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 868595004151 Walker A/P-loop; other site 868595004152 ATP binding site [chemical binding]; other site 868595004153 Q-loop/lid; other site 868595004154 ABC transporter signature motif; other site 868595004155 Walker B; other site 868595004156 D-loop; other site 868595004157 H-loop/switch region; other site 868595004158 Protein of unknown function (DUF964); Region: DUF964; cl01483 868595004159 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 868595004160 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 868595004161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004162 FeS/SAM binding site; other site 868595004163 TRAM domain; Region: TRAM; cl01282 868595004164 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 868595004165 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 868595004166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 868595004167 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 868595004168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004169 active site 868595004170 phosphorylation site [posttranslational modification] 868595004171 intermolecular recognition site; other site 868595004172 dimerization interface [polypeptide binding]; other site 868595004173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 868595004174 DNA binding residues [nucleotide binding] 868595004175 dimerization interface [polypeptide binding]; other site 868595004176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 868595004177 PAS fold; Region: PAS; pfam00989 868595004178 Histidine kinase; Region: HisKA_3; pfam07730 868595004179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004180 ATP binding site [chemical binding]; other site 868595004181 Mg2+ binding site [ion binding]; other site 868595004182 G-X-G motif; other site 868595004183 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 868595004184 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 868595004185 AMP-binding enzyme; Region: AMP-binding; cl15778 868595004186 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 868595004187 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 868595004188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004189 NAD(P) binding site [chemical binding]; other site 868595004190 active site 868595004191 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 868595004192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004193 NAD(P) binding site [chemical binding]; other site 868595004194 active site 868595004195 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 868595004196 substrate binding site; other site 868595004197 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 868595004198 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 868595004199 Ligand binding site; other site 868595004200 Putative Catalytic site; other site 868595004201 DXD motif; other site 868595004202 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 868595004203 septum formation inhibitor; Reviewed; Region: minC; PRK00513 868595004204 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 868595004205 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 868595004206 ADP-ribose binding site [chemical binding]; other site 868595004207 dimer interface [polypeptide binding]; other site 868595004208 active site 868595004209 nudix motif; other site 868595004210 metal binding site [ion binding]; metal-binding site 868595004211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 868595004212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595004213 dimerization interface [polypeptide binding]; other site 868595004214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595004215 dimer interface [polypeptide binding]; other site 868595004216 phosphorylation site [posttranslational modification] 868595004217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004218 ATP binding site [chemical binding]; other site 868595004219 Mg2+ binding site [ion binding]; other site 868595004220 G-X-G motif; other site 868595004221 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 868595004222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004223 active site 868595004224 phosphorylation site [posttranslational modification] 868595004225 intermolecular recognition site; other site 868595004226 dimerization interface [polypeptide binding]; other site 868595004227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595004228 DNA binding site [nucleotide binding] 868595004229 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595004230 MULE transposase domain; Region: MULE; pfam10551 868595004231 AAA domain; Region: AAA_31; pfam13614 868595004232 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595004233 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595004234 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 868595004235 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 868595004236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 868595004237 Coenzyme A binding pocket [chemical binding]; other site 868595004238 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 868595004239 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 868595004240 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 868595004241 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 868595004242 active site 868595004243 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 868595004244 catalytic core [active] 868595004245 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 868595004246 homotrimer interface [polypeptide binding]; other site 868595004247 Walker A motif; other site 868595004248 GTP binding site [chemical binding]; other site 868595004249 Walker B motif; other site 868595004250 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 868595004251 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 868595004252 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 868595004253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595004254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595004255 homodimer interface [polypeptide binding]; other site 868595004256 catalytic residue [active] 868595004257 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 868595004258 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 868595004259 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 868595004260 active site 868595004261 dimer interface [polypeptide binding]; other site 868595004262 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 868595004263 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 868595004264 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595004265 putative active site [active] 868595004266 metal binding site [ion binding]; metal-binding site 868595004267 homodimer binding site [polypeptide binding]; other site 868595004268 phosphodiesterase; Provisional; Region: PRK12704 868595004269 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595004270 Zn2+ binding site [ion binding]; other site 868595004271 Mg2+ binding site [ion binding]; other site 868595004272 recombinase A; Provisional; Region: recA; PRK09354 868595004273 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 868595004274 hexamer interface [polypeptide binding]; other site 868595004275 Walker A motif; other site 868595004276 ATP binding site [chemical binding]; other site 868595004277 Walker B motif; other site 868595004278 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 868595004279 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 868595004280 ATP binding site [chemical binding]; other site 868595004281 Mg++ binding site [ion binding]; other site 868595004282 motif III; other site 868595004283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595004284 nucleotide binding region [chemical binding]; other site 868595004285 ATP-binding site [chemical binding]; other site 868595004286 DbpA RNA binding domain; Region: DbpA; pfam03880 868595004287 competence damage-inducible protein A; Provisional; Region: PRK00549 868595004288 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 868595004289 putative MPT binding site; other site 868595004290 Competence-damaged protein; Region: CinA; cl00666 868595004291 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 868595004292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004293 Walker A motif; other site 868595004294 ATP binding site [chemical binding]; other site 868595004295 Walker B motif; other site 868595004296 arginine finger; other site 868595004297 Peptidase family M41; Region: Peptidase_M41; pfam01434 868595004298 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 868595004299 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 868595004300 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 868595004301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004302 FeS/SAM binding site; other site 868595004303 TRAM domain; Region: TRAM; cl01282 868595004304 Protein of unknown function (DUF520); Region: DUF520; cl00723 868595004305 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 868595004306 anaerobic ribonucleoside-triphosphate reductase; Region: RNR_anaer_Bdell; TIGR02827 868595004307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 868595004308 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 868595004309 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 868595004310 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 868595004311 active site residue [active] 868595004312 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595004313 active site 868595004314 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 868595004315 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 868595004316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595004317 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 868595004318 Coat F domain; Region: Coat_F; cl15836 868595004319 YlzJ-like protein; Region: YlzJ; pfam14035 868595004320 Clp protease; Region: CLP_protease; pfam00574 868595004321 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 868595004322 active site 868595004323 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 868595004324 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 868595004325 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 868595004326 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 868595004327 dihydrodipicolinate synthase; Region: dapA; TIGR00674 868595004328 dimer interface [polypeptide binding]; other site 868595004329 active site 868595004330 catalytic residue [active] 868595004331 aspartate kinase I; Reviewed; Region: PRK08210 868595004332 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 868595004333 putative catalytic residues [active] 868595004334 putative nucleotide binding site [chemical binding]; other site 868595004335 putative aspartate binding site [chemical binding]; other site 868595004336 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 868595004337 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 868595004338 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 868595004339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004340 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 868595004341 Flavoprotein; Region: Flavoprotein; cl08021 868595004342 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 868595004343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004344 NAD(P) binding pocket [chemical binding]; other site 868595004345 dihydrodipicolinate reductase; Provisional; Region: PRK00048 868595004346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004347 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 868595004348 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 868595004349 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 868595004350 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 868595004351 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 868595004352 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 868595004353 NodB motif; other site 868595004354 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 868595004355 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 868595004356 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595004357 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 868595004358 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 868595004359 RNase E interface [polypeptide binding]; other site 868595004360 trimer interface [polypeptide binding]; other site 868595004361 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 868595004362 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 868595004363 RNase E interface [polypeptide binding]; other site 868595004364 trimer interface [polypeptide binding]; other site 868595004365 active site 868595004366 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 868595004367 putative nucleic acid binding region [nucleotide binding]; other site 868595004368 G-X-X-G motif; other site 868595004369 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 868595004370 RNA binding site [nucleotide binding]; other site 868595004371 domain interface; other site 868595004372 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 868595004373 16S/18S rRNA binding site [nucleotide binding]; other site 868595004374 S13e-L30e interaction site [polypeptide binding]; other site 868595004375 25S rRNA binding site [nucleotide binding]; other site 868595004376 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 868595004377 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 868595004378 active site 868595004379 Riboflavin kinase; Region: Flavokinase; cl03312 868595004380 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 868595004381 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 868595004382 RNA binding site [nucleotide binding]; other site 868595004383 active site 868595004384 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 868595004385 DHH family; Region: DHH; pfam01368 868595004386 DHHA1 domain; Region: DHHA1; pfam02272 868595004387 Ribosome-binding factor A; Region: RBFA; cl00542 868595004388 translation initiation factor IF-2; Validated; Region: infB; PRK05306 868595004389 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 868595004390 translation initiation factor IF-2; Region: IF-2; TIGR00487 868595004391 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 868595004392 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 868595004393 G1 box; other site 868595004394 putative GEF interaction site [polypeptide binding]; other site 868595004395 GTP/Mg2+ binding site [chemical binding]; other site 868595004396 Switch I region; other site 868595004397 G2 box; other site 868595004398 G3 box; other site 868595004399 Switch II region; other site 868595004400 G4 box; other site 868595004401 G5 box; other site 868595004402 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 868595004403 Translation-initiation factor 2; Region: IF-2; pfam11987 868595004404 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 868595004405 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 868595004406 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 868595004407 putative RNA binding cleft [nucleotide binding]; other site 868595004408 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 868595004409 NusA N-terminal domain; Region: NusA_N; pfam08529 868595004410 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 868595004411 RNA binding site [nucleotide binding]; other site 868595004412 homodimer interface [polypeptide binding]; other site 868595004413 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 868595004414 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 868595004415 G-X-X-G motif; other site 868595004416 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 868595004417 ribosome maturation protein RimP; Reviewed; Region: PRK00092 868595004418 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 868595004419 Sm1 motif; other site 868595004420 predicted subunit interaction site [polypeptide binding]; other site 868595004421 RNA binding pocket [nucleotide binding]; other site 868595004422 Sm2 motif; other site 868595004423 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 868595004424 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 868595004425 NodB motif; other site 868595004426 active site 868595004427 catalytic site [active] 868595004428 Cd binding site [ion binding]; other site 868595004429 Bacterial Ig-like domain; Region: Big_5; cl01012 868595004430 DNA polymerase III PolC; Validated; Region: polC; PRK00448 868595004431 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 868595004432 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 868595004433 generic binding surface II; other site 868595004434 generic binding surface I; other site 868595004435 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 868595004436 active site 868595004437 substrate binding site [chemical binding]; other site 868595004438 catalytic site [active] 868595004439 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 868595004440 Protein of unknown function, DUF655; Region: DUF655; pfam04919 868595004441 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 868595004442 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 868595004443 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 868595004444 prolyl-tRNA synthetase; Provisional; Region: PRK09194 868595004445 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 868595004446 dimer interface [polypeptide binding]; other site 868595004447 motif 1; other site 868595004448 active site 868595004449 motif 2; other site 868595004450 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 868595004451 putative deacylase active site [active] 868595004452 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 868595004453 active site 868595004454 motif 3; other site 868595004455 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 868595004456 anticodon binding site; other site 868595004457 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 868595004458 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 868595004459 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 868595004460 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 868595004461 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 868595004462 active site 868595004463 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 868595004464 protein binding site [polypeptide binding]; other site 868595004465 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 868595004466 putative substrate binding region [chemical binding]; other site 868595004467 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 868595004468 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 868595004469 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 868595004470 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 868595004471 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 868595004472 Domain of unknown function DUF20; Region: UPF0118; pfam01594 868595004473 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 868595004474 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 868595004475 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 868595004476 catalytic residue [active] 868595004477 putative FPP diphosphate binding site; other site 868595004478 putative FPP binding hydrophobic cleft; other site 868595004479 dimer interface [polypeptide binding]; other site 868595004480 putative IPP diphosphate binding site; other site 868595004481 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595004482 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 868595004483 ribosome recycling factor; Reviewed; Region: frr; PRK00083 868595004484 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 868595004485 hinge region; other site 868595004486 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 868595004487 putative nucleotide binding site [chemical binding]; other site 868595004488 uridine monophosphate binding site [chemical binding]; other site 868595004489 homohexameric interface [polypeptide binding]; other site 868595004490 elongation factor Ts; Reviewed; Region: tsf; PRK12332 868595004491 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 868595004492 Elongation factor TS; Region: EF_TS; pfam00889 868595004493 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 868595004494 rRNA interaction site [nucleotide binding]; other site 868595004495 S8 interaction site; other site 868595004496 putative laminin-1 binding site; other site 868595004497 transcriptional repressor CodY; Validated; Region: PRK04158 868595004498 CodY GAF-like domain; Region: CodY; pfam06018 868595004499 Helix-turn-helix domains; Region: HTH; cl00088 868595004500 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 868595004501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004502 Walker A motif; other site 868595004503 ATP binding site [chemical binding]; other site 868595004504 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595004505 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 868595004506 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 868595004507 active site 868595004508 HslU subunit interaction site [polypeptide binding]; other site 868595004509 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 868595004510 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 868595004511 Int/Topo IB signature motif; other site 868595004512 active site 868595004513 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 868595004514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004515 DNA topoisomerase I; Validated; Region: PRK05582 868595004516 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 868595004517 active site 868595004518 interdomain interaction site; other site 868595004519 putative metal-binding site [ion binding]; other site 868595004520 nucleotide binding site [chemical binding]; other site 868595004521 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 868595004522 domain I; other site 868595004523 DNA binding groove [nucleotide binding] 868595004524 phosphate binding site [ion binding]; other site 868595004525 domain II; other site 868595004526 domain III; other site 868595004527 nucleotide binding site [chemical binding]; other site 868595004528 catalytic site [active] 868595004529 domain IV; other site 868595004530 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 868595004531 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 868595004532 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 868595004533 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 868595004534 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 868595004535 nucleotide binding site [chemical binding]; other site 868595004536 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 868595004537 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 868595004538 homodimer interface [polypeptide binding]; other site 868595004539 substrate-cofactor binding pocket; other site 868595004540 catalytic residue [active] 868595004541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 868595004542 PAS fold; Region: PAS_4; pfam08448 868595004543 PAS domain; Region: PAS_9; pfam13426 868595004544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595004545 putative active site [active] 868595004546 heme pocket [chemical binding]; other site 868595004547 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 868595004548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595004549 putative active site [active] 868595004550 heme pocket [chemical binding]; other site 868595004551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595004552 dimer interface [polypeptide binding]; other site 868595004553 phosphorylation site [posttranslational modification] 868595004554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004555 ATP binding site [chemical binding]; other site 868595004556 Mg2+ binding site [ion binding]; other site 868595004557 G-X-G motif; other site 868595004558 Response regulator receiver domain; Region: Response_reg; pfam00072 868595004559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004560 active site 868595004561 phosphorylation site [posttranslational modification] 868595004562 intermolecular recognition site; other site 868595004563 dimerization interface [polypeptide binding]; other site 868595004564 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 868595004565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004566 active site 868595004567 phosphorylation site [posttranslational modification] 868595004568 intermolecular recognition site; other site 868595004569 dimerization interface [polypeptide binding]; other site 868595004570 Response regulator receiver domain; Region: Response_reg; pfam00072 868595004571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004572 active site 868595004573 phosphorylation site [posttranslational modification] 868595004574 intermolecular recognition site; other site 868595004575 dimerization interface [polypeptide binding]; other site 868595004576 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 868595004577 NAD-dependent deacetylase; Provisional; Region: PRK00481 868595004578 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 868595004579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004580 FeS/SAM binding site; other site 868595004581 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 868595004582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 868595004583 DNA-binding site [nucleotide binding]; DNA binding site 868595004584 Transcriptional regulators [Transcription]; Region: FadR; COG2186 868595004585 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 868595004586 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 868595004587 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004588 FeS/SAM binding site; other site 868595004589 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 868595004590 biotin synthase; Provisional; Region: PRK07094 868595004591 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004592 FeS/SAM binding site; other site 868595004593 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 868595004594 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 868595004595 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 868595004596 putative CheA interaction surface; other site 868595004597 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 868595004598 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 868595004599 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 868595004600 inhibitor-cofactor binding pocket; inhibition site 868595004601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595004602 catalytic residue [active] 868595004603 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 868595004604 Helix-turn-helix domains; Region: HTH; cl00088 868595004605 Helix-turn-helix domains; Region: HTH; cl00088 868595004606 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 868595004607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004608 FeS/SAM binding site; other site 868595004609 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 868595004610 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 868595004611 dimer interface [polypeptide binding]; other site 868595004612 active site 868595004613 Schiff base residues; other site 868595004614 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 868595004615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004616 FeS/SAM binding site; other site 868595004617 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 868595004618 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 868595004619 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 868595004620 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 868595004621 active site 868595004622 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 868595004623 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 868595004624 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 868595004625 domain interfaces; other site 868595004626 active site 868595004627 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 868595004628 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 868595004629 tRNA; other site 868595004630 putative tRNA binding site [nucleotide binding]; other site 868595004631 putative NADP binding site [chemical binding]; other site 868595004632 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 868595004633 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 868595004634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004635 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 868595004636 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 868595004637 substrate binding pocket [chemical binding]; other site 868595004638 chain length determination region; other site 868595004639 substrate-Mg2+ binding site; other site 868595004640 catalytic residues [active] 868595004641 aspartate-rich region 1; other site 868595004642 active site lid residues [active] 868595004643 aspartate-rich region 2; other site 868595004644 Flagellin N-methylase; Region: FliB; cl00497 868595004645 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 868595004646 Ligand Binding Site [chemical binding]; other site 868595004647 S-layer homology domain; Region: SLH; pfam00395 868595004648 PrcB C-terminal; Region: PrcB_C; pfam14343 868595004649 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 868595004650 DNA-binding site [nucleotide binding]; DNA binding site 868595004651 RNA-binding motif; other site 868595004652 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595004653 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 868595004654 Walker A/P-loop; other site 868595004655 ATP binding site [chemical binding]; other site 868595004656 Q-loop/lid; other site 868595004657 ABC transporter signature motif; other site 868595004658 Walker B; other site 868595004659 D-loop; other site 868595004660 H-loop/switch region; other site 868595004661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595004662 dimer interface [polypeptide binding]; other site 868595004663 conserved gate region; other site 868595004664 putative PBP binding loops; other site 868595004665 ABC-ATPase subunit interface; other site 868595004666 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 868595004667 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 868595004668 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 868595004669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 868595004670 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 868595004671 catalytic core [active] 868595004672 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 868595004673 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 868595004674 Ligand binding site; other site 868595004675 metal-binding site 868595004676 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 868595004677 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595004678 Zn2+ binding site [ion binding]; other site 868595004679 Mg2+ binding site [ion binding]; other site 868595004680 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 868595004681 XdhC Rossmann domain; Region: XdhC_C; pfam13478 868595004682 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 868595004683 AMP-binding enzyme; Region: AMP-binding; cl15778 868595004684 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004685 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 868595004686 FeS/SAM binding site; other site 868595004687 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 868595004688 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 868595004689 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 868595004690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595004691 S-adenosylmethionine binding site [chemical binding]; other site 868595004692 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 868595004693 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 868595004694 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595004695 Cysteine-rich domain; Region: CCG; pfam02754 868595004696 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 868595004697 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 868595004698 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 868595004699 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 868595004700 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 868595004701 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 868595004702 putative MPT binding site; other site 868595004703 Nucleoside recognition; Region: Gate; cl00486 868595004704 Nucleoside recognition; Region: Gate; cl00486 868595004705 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 868595004706 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 868595004707 G1 box; other site 868595004708 putative GEF interaction site [polypeptide binding]; other site 868595004709 GTP/Mg2+ binding site [chemical binding]; other site 868595004710 Switch I region; other site 868595004711 G2 box; other site 868595004712 G3 box; other site 868595004713 Switch II region; other site 868595004714 G4 box; other site 868595004715 G5 box; other site 868595004716 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 868595004717 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 868595004718 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 868595004719 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 868595004720 selenocysteine synthase; Provisional; Region: PRK04311 868595004721 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 868595004722 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 868595004723 Transcriptional regulators [Transcription]; Region: FadR; COG2186 868595004724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 868595004725 DNA-binding site [nucleotide binding]; DNA binding site 868595004726 FCD domain; Region: FCD; cl11656 868595004727 L-lactate permease; Region: Lactate_perm; cl00701 868595004728 glycolate transporter; Provisional; Region: PRK09695 868595004729 Predicted amidohydrolase [General function prediction only]; Region: COG0388 868595004730 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 868595004731 putative active site [active] 868595004732 catalytic triad [active] 868595004733 putative dimer interface [polypeptide binding]; other site 868595004734 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 868595004735 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 868595004736 FAD binding site [chemical binding]; other site 868595004737 Rubrerythrin [Energy production and conversion]; Region: COG1592 868595004738 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 868595004739 binuclear metal center [ion binding]; other site 868595004740 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 868595004741 iron binding site [ion binding]; other site 868595004742 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 868595004743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004744 FeS/SAM binding site; other site 868595004745 NMT1-like family; Region: NMT1_2; cl15260 868595004746 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 868595004747 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 868595004748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004749 FeS/SAM binding site; other site 868595004750 UbiA prenyltransferase family; Region: UbiA; cl00337 868595004751 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 868595004752 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 868595004753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595004754 S-adenosylmethionine binding site [chemical binding]; other site 868595004755 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 868595004756 substrate binding pocket [chemical binding]; other site 868595004757 aspartate-rich region 1; other site 868595004758 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 868595004759 Sulfatase; Region: Sulfatase; cl10460 868595004760 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 868595004761 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 868595004762 putative ADP-binding pocket [chemical binding]; other site 868595004763 4Fe-4S binding domain; Region: Fer4; cl02805 868595004764 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 868595004765 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 868595004766 4Fe-4S binding domain; Region: Fer4; cl02805 868595004767 Transposase domain (DUF772); Region: DUF772; cl15789 868595004768 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595004769 Transposase domain (DUF772); Region: DUF772; cl15789 868595004770 Transposase domain (DUF772); Region: DUF772; cl15789 868595004771 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595004772 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 868595004773 catalytic loop [active] 868595004774 iron binding site [ion binding]; other site 868595004775 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 868595004776 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 868595004777 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 868595004778 substrate binding pocket [chemical binding]; other site 868595004779 inhibitor binding site; inhibition site 868595004780 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 868595004781 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 868595004782 B12 binding site [chemical binding]; other site 868595004783 cobalt ligand [ion binding]; other site 868595004784 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 868595004785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004786 flavoprotein, HI0933 family; Region: TIGR00275 868595004787 GTP-binding protein YchF; Reviewed; Region: PRK09601 868595004788 YchF GTPase; Region: YchF; cd01900 868595004789 G1 box; other site 868595004790 GTP/Mg2+ binding site [chemical binding]; other site 868595004791 Switch I region; other site 868595004792 G2 box; other site 868595004793 Switch II region; other site 868595004794 G3 box; other site 868595004795 G4 box; other site 868595004796 G5 box; other site 868595004797 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 868595004798 Rubrerythrin [Energy production and conversion]; Region: COG1592 868595004799 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 868595004800 binuclear metal center [ion binding]; other site 868595004801 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 868595004802 iron binding site [ion binding]; other site 868595004803 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 868595004804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595004805 non-specific DNA binding site [nucleotide binding]; other site 868595004806 salt bridge; other site 868595004807 sequence-specific DNA binding site [nucleotide binding]; other site 868595004808 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 868595004809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004810 active site 868595004811 phosphorylation site [posttranslational modification] 868595004812 intermolecular recognition site; other site 868595004813 dimerization interface [polypeptide binding]; other site 868595004814 PAS domain S-box; Region: sensory_box; TIGR00229 868595004815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595004816 putative active site [active] 868595004817 heme pocket [chemical binding]; other site 868595004818 PAS domain S-box; Region: sensory_box; TIGR00229 868595004819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595004820 putative active site [active] 868595004821 heme pocket [chemical binding]; other site 868595004822 PAS domain S-box; Region: sensory_box; TIGR00229 868595004823 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595004824 putative active site [active] 868595004825 heme pocket [chemical binding]; other site 868595004826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595004827 metal binding site [ion binding]; metal-binding site 868595004828 active site 868595004829 I-site; other site 868595004830 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 868595004831 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 868595004832 DXD motif; other site 868595004833 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595004834 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 868595004835 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 868595004836 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 868595004837 SWIM zinc finger; Region: SWIM; cl15408 868595004838 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595004839 MULE transposase domain; Region: MULE; pfam10551 868595004840 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 868595004841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004842 Walker A motif; other site 868595004843 ATP binding site [chemical binding]; other site 868595004844 Walker B motif; other site 868595004845 arginine finger; other site 868595004846 Integrase core domain; Region: rve; cl01316 868595004847 Integrase core domain; Region: rve_3; cl15866 868595004848 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 868595004849 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 868595004850 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 868595004851 active site 868595004852 NTP binding site [chemical binding]; other site 868595004853 metal binding triad [ion binding]; metal-binding site 868595004854 CHASE3 domain; Region: CHASE3; cl05000 868595004855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595004856 dimerization interface [polypeptide binding]; other site 868595004857 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 868595004858 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595004859 dimer interface [polypeptide binding]; other site 868595004860 putative CheW interface [polypeptide binding]; other site 868595004861 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 868595004862 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 868595004863 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 868595004864 metal-binding site [ion binding] 868595004865 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 868595004866 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 868595004867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 868595004868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595004869 dimerization interface [polypeptide binding]; other site 868595004870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595004871 dimer interface [polypeptide binding]; other site 868595004872 phosphorylation site [posttranslational modification] 868595004873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004874 ATP binding site [chemical binding]; other site 868595004875 Mg2+ binding site [ion binding]; other site 868595004876 G-X-G motif; other site 868595004877 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595004878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004879 active site 868595004880 phosphorylation site [posttranslational modification] 868595004881 intermolecular recognition site; other site 868595004882 dimerization interface [polypeptide binding]; other site 868595004883 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595004884 DNA binding site [nucleotide binding] 868595004885 Peptidase M15; Region: Peptidase_M15_3; cl01194 868595004886 YvrJ protein family; Region: YvrJ; pfam12841 868595004887 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 868595004888 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 868595004889 SWIM zinc finger; Region: SWIM; cl15408 868595004890 Endodeoxyribonuclease RusA; Region: RusA; cl01885 868595004891 hypothetical protein; Validated; Region: PRK08116 868595004892 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595004893 TRAM domain; Region: TRAM; cl01282 868595004894 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 868595004895 EamA-like transporter family; Region: EamA; cl01037 868595004896 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 868595004897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595004898 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595004899 putative substrate translocation pore; other site 868595004900 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 868595004901 Walker A motif; other site 868595004902 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 868595004903 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 868595004904 ATP binding site [chemical binding]; other site 868595004905 substrate interface [chemical binding]; other site 868595004906 MOSC domain; Region: MOSC; pfam03473 868595004907 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 868595004908 trimer interface [polypeptide binding]; other site 868595004909 dimer interface [polypeptide binding]; other site 868595004910 putative active site [active] 868595004911 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 868595004912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004913 FeS/SAM binding site; other site 868595004914 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 868595004915 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595004916 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 868595004917 Walker A/P-loop; other site 868595004918 ATP binding site [chemical binding]; other site 868595004919 Q-loop/lid; other site 868595004920 ABC transporter signature motif; other site 868595004921 Walker B; other site 868595004922 D-loop; other site 868595004923 H-loop/switch region; other site 868595004924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 868595004925 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 868595004926 MoaE interaction surface [polypeptide binding]; other site 868595004927 thiocarboxylated glycine; other site 868595004928 Ubiquitin-like proteins; Region: UBQ; cl00155 868595004929 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 868595004930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004931 active site 868595004932 phosphorylation site [posttranslational modification] 868595004933 intermolecular recognition site; other site 868595004934 dimerization interface [polypeptide binding]; other site 868595004935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004936 Walker A motif; other site 868595004937 ATP binding site [chemical binding]; other site 868595004938 Walker B motif; other site 868595004939 Helix-turn-helix domains; Region: HTH; cl00088 868595004940 GAF domain; Region: GAF; cl15785 868595004941 GAF domain; Region: GAF_2; pfam13185 868595004942 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 868595004943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595004944 dimer interface [polypeptide binding]; other site 868595004945 phosphorylation site [posttranslational modification] 868595004946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004947 ATP binding site [chemical binding]; other site 868595004948 G-X-G motif; other site 868595004949 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 868595004950 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 868595004951 putative active site [active] 868595004952 metal binding site [ion binding]; metal-binding site 868595004953 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 868595004954 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 868595004955 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 868595004956 putative active site [active] 868595004957 putative NTP binding site [chemical binding]; other site 868595004958 putative nucleic acid binding site [nucleotide binding]; other site 868595004959 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 868595004960 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 868595004961 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 868595004962 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 868595004963 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 868595004964 putative alcohol dehydrogenase; Provisional; Region: PRK09860 868595004965 dimer interface [polypeptide binding]; other site 868595004966 active site 868595004967 metal binding site [ion binding]; metal-binding site 868595004968 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595004969 metal binding site [ion binding]; metal-binding site 868595004970 active site 868595004971 I-site; other site 868595004972 Predicted amidohydrolase [General function prediction only]; Region: COG0388 868595004973 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 868595004974 putative active site [active] 868595004975 catalytic triad [active] 868595004976 dimer interface [polypeptide binding]; other site 868595004977 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 868595004978 active site 868595004979 metal binding site [ion binding]; metal-binding site 868595004980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 868595004981 Helix-turn-helix domains; Region: HTH; cl00088 868595004982 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 868595004983 putative dimerization interface [polypeptide binding]; other site 868595004984 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 868595004985 Putative zinc-finger; Region: zf-HC2; cl15806 868595004986 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 868595004987 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 868595004988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595004989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595004990 DNA binding residues [nucleotide binding] 868595004991 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595004992 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595004993 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595004994 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 868595004995 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 868595004996 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 868595004997 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595004998 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 868595004999 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 868595005000 substrate binding site [chemical binding]; other site 868595005001 active site 868595005002 catalytic residues [active] 868595005003 heterodimer interface [polypeptide binding]; other site 868595005004 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 868595005005 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 868595005006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595005007 catalytic residue [active] 868595005008 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 868595005009 active site 868595005010 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 868595005011 active site 868595005012 ribulose/triose binding site [chemical binding]; other site 868595005013 phosphate binding site [ion binding]; other site 868595005014 substrate (anthranilate) binding pocket [chemical binding]; other site 868595005015 product (indole) binding pocket [chemical binding]; other site 868595005016 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 868595005017 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 868595005018 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 868595005019 Glutamine amidotransferase class-I; Region: GATase; pfam00117 868595005020 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 868595005021 glutamine binding [chemical binding]; other site 868595005022 catalytic triad [active] 868595005023 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 868595005024 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 868595005025 chorismate binding enzyme; Region: Chorismate_bind; cl10555 868595005026 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 868595005027 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 868595005028 active site 868595005029 catalytic triad [active] 868595005030 oxyanion hole [active] 868595005031 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 868595005032 pyruvate kinase; Provisional; Region: PRK06354 868595005033 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 868595005034 domain interfaces; other site 868595005035 active site 868595005036 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 868595005037 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 868595005038 active site 868595005039 ADP/pyrophosphate binding site [chemical binding]; other site 868595005040 dimerization interface [polypeptide binding]; other site 868595005041 allosteric effector site; other site 868595005042 fructose-1,6-bisphosphate binding site; other site 868595005043 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 868595005044 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 868595005045 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 868595005046 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 868595005047 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 868595005048 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 868595005049 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 868595005050 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 868595005051 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 868595005052 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 868595005053 generic binding surface II; other site 868595005054 generic binding surface I; other site 868595005055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 868595005056 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 868595005057 NlpC/P60 family; Region: NLPC_P60; cl11438 868595005058 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 868595005059 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595005060 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595005061 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595005062 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595005063 DNA binding residues [nucleotide binding] 868595005064 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595005065 catalytic residues [active] 868595005066 catalytic nucleophile [active] 868595005067 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 868595005068 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 868595005069 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 868595005070 Uncharacterized conserved protein [Function unknown]; Region: COG1543 868595005071 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 868595005072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 868595005073 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 868595005074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595005075 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 868595005076 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 868595005077 minor groove reading motif; other site 868595005078 helix-hairpin-helix signature motif; other site 868595005079 substrate binding pocket [chemical binding]; other site 868595005080 active site 868595005081 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 868595005082 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 868595005083 alanyl-tRNA synthetase; Region: A-tRNA_syn_arch; TIGR03683 868595005084 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 868595005085 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 868595005086 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 868595005087 active site 868595005088 Substrate binding site; other site 868595005089 Mg++ binding site; other site 868595005090 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 868595005091 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 868595005092 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 868595005093 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 868595005094 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595005095 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 868595005096 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 868595005097 PspA/IM30 family; Region: PspA_IM30; pfam04012 868595005098 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 868595005099 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 868595005100 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 868595005101 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 868595005102 tartrate dehydrogenase; Provisional; Region: PRK08194 868595005103 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 868595005104 substrate binding site [chemical binding]; other site 868595005105 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 868595005106 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 868595005107 substrate binding site [chemical binding]; other site 868595005108 ligand binding site [chemical binding]; other site 868595005109 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 868595005110 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 868595005111 active site 868595005112 catalytic residues [active] 868595005113 metal binding site [ion binding]; metal-binding site 868595005114 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 868595005115 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 868595005116 GatB domain; Region: GatB_Yqey; cl11497 868595005117 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 868595005118 Amidase; Region: Amidase; cl11426 868595005119 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 868595005120 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 868595005121 homotrimer interaction site [polypeptide binding]; other site 868595005122 putative active site [active] 868595005123 S-layer homology domain; Region: SLH; pfam00395 868595005124 S-layer homology domain; Region: SLH; pfam00395 868595005125 PQQ-like domain; Region: PQQ_2; pfam13360 868595005126 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 868595005127 active site 868595005128 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 868595005129 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 868595005130 nucleotide binding pocket [chemical binding]; other site 868595005131 K-X-D-G motif; other site 868595005132 catalytic site [active] 868595005133 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 868595005134 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 868595005135 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 868595005136 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 868595005137 Dimer interface [polypeptide binding]; other site 868595005138 BRCT sequence motif; other site 868595005139 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 868595005140 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 868595005141 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595005142 Family description; Region: UvrD_C_2; cl15862 868595005143 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 868595005144 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 868595005145 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 868595005146 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 868595005147 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 868595005148 substrate binding site [chemical binding]; other site 868595005149 glutamase interaction surface [polypeptide binding]; other site 868595005150 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 868595005151 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 868595005152 catalytic residues [active] 868595005153 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 868595005154 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 868595005155 putative active site [active] 868595005156 oxyanion strand; other site 868595005157 catalytic triad [active] 868595005158 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 868595005159 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 868595005160 putative active site pocket [active] 868595005161 4-fold oligomerization interface [polypeptide binding]; other site 868595005162 metal binding residues [ion binding]; metal-binding site 868595005163 3-fold/trimer interface [polypeptide binding]; other site 868595005164 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595005165 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595005166 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 868595005167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595005168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595005169 homodimer interface [polypeptide binding]; other site 868595005170 catalytic residue [active] 868595005171 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 868595005172 histidinol dehydrogenase; Region: hisD; TIGR00069 868595005173 NAD binding site [chemical binding]; other site 868595005174 dimerization interface [polypeptide binding]; other site 868595005175 product binding site; other site 868595005176 substrate binding site [chemical binding]; other site 868595005177 zinc binding site [ion binding]; other site 868595005178 catalytic residues [active] 868595005179 ATP phosphoribosyltransferase; Region: HisG; cl15266 868595005180 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 868595005181 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 868595005182 dimer interface [polypeptide binding]; other site 868595005183 motif 1; other site 868595005184 active site 868595005185 motif 2; other site 868595005186 motif 3; other site 868595005187 Helix-turn-helix domains; Region: HTH; cl00088 868595005188 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 868595005189 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 868595005190 ATP-grasp domain; Region: ATP-grasp_4; cl03087 868595005191 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 868595005192 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 868595005193 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 868595005194 purine monophosphate binding site [chemical binding]; other site 868595005195 dimer interface [polypeptide binding]; other site 868595005196 putative catalytic residues [active] 868595005197 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 868595005198 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 868595005199 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 868595005200 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 868595005201 active site 868595005202 substrate binding site [chemical binding]; other site 868595005203 cosubstrate binding site; other site 868595005204 catalytic site [active] 868595005205 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 868595005206 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 868595005207 dimerization interface [polypeptide binding]; other site 868595005208 putative ATP binding site [chemical binding]; other site 868595005209 amidophosphoribosyltransferase; Provisional; Region: PRK05793 868595005210 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 868595005211 active site 868595005212 tetramer interface [polypeptide binding]; other site 868595005213 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595005214 active site 868595005215 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 868595005216 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 868595005217 dimerization interface [polypeptide binding]; other site 868595005218 ATP binding site [chemical binding]; other site 868595005219 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 868595005220 dimerization interface [polypeptide binding]; other site 868595005221 ATP binding site [chemical binding]; other site 868595005222 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 868595005223 putative active site [active] 868595005224 catalytic triad [active] 868595005225 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 868595005226 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 868595005227 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 868595005228 ATP binding site [chemical binding]; other site 868595005229 active site 868595005230 substrate binding site [chemical binding]; other site 868595005231 adenylosuccinate lyase; Provisional; Region: PRK07492 868595005232 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 868595005233 tetramer interface [polypeptide binding]; other site 868595005234 active site 868595005235 AIR carboxylase; Region: AIRC; cl00310 868595005236 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 868595005237 GMP synthase; Reviewed; Region: guaA; PRK00074 868595005238 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 868595005239 AMP/PPi binding site [chemical binding]; other site 868595005240 candidate oxyanion hole; other site 868595005241 catalytic triad [active] 868595005242 potential glutamine specificity residues [chemical binding]; other site 868595005243 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 868595005244 ATP Binding subdomain [chemical binding]; other site 868595005245 Ligand Binding sites [chemical binding]; other site 868595005246 Dimerization subdomain; other site 868595005247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595005248 active site 868595005249 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 868595005250 flagellar motor switch protein; Validated; Region: PRK08119 868595005251 Chemotaxis phosphatase CheX; Region: CheX; cl15816 868595005252 Chemotaxis phosphatase CheX; Region: CheX; cl15816 868595005253 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 868595005254 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 868595005255 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 868595005256 Response regulator receiver domain; Region: Response_reg; pfam00072 868595005257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595005258 active site 868595005259 phosphorylation site [posttranslational modification] 868595005260 intermolecular recognition site; other site 868595005261 dimerization interface [polypeptide binding]; other site 868595005262 Transposase domain (DUF772); Region: DUF772; cl15789 868595005263 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595005264 Transposase domain (DUF772); Region: DUF772; cl15789 868595005265 Transposase domain (DUF772); Region: DUF772; cl15789 868595005266 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 868595005267 Chemotaxis phosphatase CheX; Region: CheX; cl15816 868595005268 Chemotaxis phosphatase CheX; Region: CheX; cl15816 868595005269 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 868595005270 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 868595005271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595005272 CheD chemotactic sensory transduction; Region: CheD; cl00810 868595005273 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 868595005274 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 868595005275 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 868595005276 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 868595005277 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 868595005278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595005279 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 868595005280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595005281 DNA binding residues [nucleotide binding] 868595005282 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 868595005283 Flagellar protein YcgR; Region: YcgR_2; pfam12945 868595005284 PilZ domain; Region: PilZ; cl01260 868595005285 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 868595005286 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 868595005287 P-loop; other site 868595005288 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 868595005289 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 868595005290 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595005291 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 868595005292 FHIPEP family; Region: FHIPEP; pfam00771 868595005293 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 868595005294 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 868595005295 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 868595005296 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 868595005297 FliP family; Region: FliP; cl00593 868595005298 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 868595005299 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 868595005300 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 868595005301 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 868595005302 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 868595005303 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 868595005304 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 868595005305 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 868595005306 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 868595005307 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 868595005308 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 868595005309 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 868595005310 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 868595005311 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 868595005312 Walker A motif/ATP binding site; other site 868595005313 Walker B motif; other site 868595005314 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 868595005315 Plant ATP synthase F0; Region: YMF19; cl07975 868595005316 Flagellar assembly protein FliH; Region: FliH; pfam02108 868595005317 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 868595005318 FliG C-terminal domain; Region: FliG_C; pfam01706 868595005319 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 868595005320 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 868595005321 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 868595005322 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 868595005323 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 868595005324 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 868595005325 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 868595005326 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 868595005327 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 868595005328 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 868595005329 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 868595005330 inhibitor-cofactor binding pocket; inhibition site 868595005331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595005332 catalytic residue [active] 868595005333 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 868595005334 active site 868595005335 NTP binding site [chemical binding]; other site 868595005336 metal binding triad [ion binding]; metal-binding site 868595005337 antibiotic binding site [chemical binding]; other site 868595005338 Protein of unknown function DUF86; Region: DUF86; cl01031 868595005339 FlaG protein; Region: FlaG; cl00591 868595005340 Flagellar protein FliS; Region: FliS; cl00654 868595005341 FliW protein; Region: FliW; cl00740 868595005342 Global regulator protein family; Region: CsrA; cl00670 868595005343 flagellar capping protein; Validated; Region: fliD; PRK07737 868595005344 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 868595005345 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 868595005346 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 868595005347 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 868595005348 Integrase core domain; Region: rve; cl01316 868595005349 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 868595005350 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595005351 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595005352 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595005353 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595005354 DNA binding residues [nucleotide binding] 868595005355 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595005356 catalytic residues [active] 868595005357 catalytic nucleophile [active] 868595005358 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 868595005359 Transposase IS200 like; Region: Y1_Tnp; cl00848 868595005360 Putative motility protein; Region: YjfB_motility; pfam14070 868595005361 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 868595005362 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 868595005363 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 868595005364 FlaG protein; Region: FlaG; cl00591 868595005365 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 868595005366 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 868595005367 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 868595005368 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 868595005369 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 868595005370 FlgN protein; Region: FlgN; cl09176 868595005371 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 868595005372 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 868595005373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595005374 active site 868595005375 phosphorylation site [posttranslational modification] 868595005376 intermolecular recognition site; other site 868595005377 dimerization interface [polypeptide binding]; other site 868595005378 CheB methylesterase; Region: CheB_methylest; pfam01339 868595005379 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 868595005380 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 868595005381 putative binding surface; other site 868595005382 active site 868595005383 P2 response regulator binding domain; Region: P2; pfam07194 868595005384 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 868595005385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595005386 ATP binding site [chemical binding]; other site 868595005387 Mg2+ binding site [ion binding]; other site 868595005388 G-X-G motif; other site 868595005389 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 868595005390 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 868595005391 putative CheA interaction surface; other site 868595005392 flagellar motor protein MotD; Reviewed; Region: PRK09038 868595005393 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 868595005394 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 868595005395 ligand binding site [chemical binding]; other site 868595005396 flagellar motor protein MotA; Validated; Region: PRK08124 868595005397 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 868595005398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 868595005399 Transposase; Region: DEDD_Tnp_IS110; pfam01548 868595005400 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 868595005401 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 868595005402 helix-hairpin-helix signature motif; other site 868595005403 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 868595005404 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 868595005405 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 868595005406 active site 868595005407 8-oxo-dGMP binding site [chemical binding]; other site 868595005408 nudix motif; other site 868595005409 metal binding site [ion binding]; metal-binding site 868595005410 pyrophosphatase PpaX; Provisional; Region: PRK13288 868595005411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595005412 motif II; other site 868595005413 Transposase domain (DUF772); Region: DUF772; cl15789 868595005414 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595005415 Transposase domain (DUF772); Region: DUF772; cl15789 868595005416 Transposase domain (DUF772); Region: DUF772; cl15789 868595005417 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 868595005418 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 868595005419 RNA/DNA hybrid binding site [nucleotide binding]; other site 868595005420 active site 868595005421 oligoendopeptidase F; Region: pepF; TIGR00181 868595005422 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 868595005423 active site 868595005424 Zn binding site [ion binding]; other site 868595005425 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 868595005426 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 868595005427 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 868595005428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595005429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 868595005430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595005431 dimerization interface [polypeptide binding]; other site 868595005432 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595005433 dimer interface [polypeptide binding]; other site 868595005434 putative CheW interface [polypeptide binding]; other site 868595005435 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 868595005436 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 868595005437 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 868595005438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595005439 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 868595005440 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595005441 DNA binding residues [nucleotide binding] 868595005442 DNA primase; Validated; Region: dnaG; PRK05667 868595005443 CHC2 zinc finger; Region: zf-CHC2; cl15369 868595005444 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 868595005445 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 868595005446 active site 868595005447 metal binding site [ion binding]; metal-binding site 868595005448 interdomain interaction site; other site 868595005449 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 868595005450 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 868595005451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595005452 Zn2+ binding site [ion binding]; other site 868595005453 Mg2+ binding site [ion binding]; other site 868595005454 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 868595005455 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 868595005456 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 868595005457 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 868595005458 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 868595005459 pyruvate phosphate dikinase; Provisional; Region: PRK09279 868595005460 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 868595005461 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 868595005462 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 868595005463 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 868595005464 Helix-turn-helix domains; Region: HTH; cl00088 868595005465 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 868595005466 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 868595005467 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 868595005468 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 868595005469 dimer interface [polypeptide binding]; other site 868595005470 motif 1; other site 868595005471 active site 868595005472 motif 2; other site 868595005473 motif 3; other site 868595005474 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 868595005475 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 868595005476 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 868595005477 Recombination protein O N terminal; Region: RecO_N; cl15812 868595005478 Recombination protein O C terminal; Region: RecO_C; pfam02565 868595005479 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 868595005480 diiron binding motif [ion binding]; other site 868595005481 S-layer homology domain; Region: SLH; pfam00395 868595005482 S-layer homology domain; Region: SLH; pfam00395 868595005483 GTPase Era; Reviewed; Region: era; PRK00089 868595005484 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 868595005485 G1 box; other site 868595005486 GTP/Mg2+ binding site [chemical binding]; other site 868595005487 Switch I region; other site 868595005488 G2 box; other site 868595005489 Switch II region; other site 868595005490 G3 box; other site 868595005491 G4 box; other site 868595005492 G5 box; other site 868595005493 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 868595005494 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 868595005495 active site 868595005496 catalytic motif [active] 868595005497 Zn binding site [ion binding]; other site 868595005498 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 868595005499 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 868595005500 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 868595005501 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 868595005502 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595005503 Zn2+ binding site [ion binding]; other site 868595005504 Mg2+ binding site [ion binding]; other site 868595005505 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 868595005506 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595005507 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 868595005508 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 868595005509 YabP family; Region: YabP; cl06766 868595005510 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 868595005511 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 868595005512 nucleotide binding site/active site [active] 868595005513 HIT family signature motif; other site 868595005514 catalytic residue [active] 868595005515 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 868595005516 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 868595005517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595005518 FeS/SAM binding site; other site 868595005519 TRAM domain; Region: TRAM; cl01282 868595005520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 868595005521 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 868595005522 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 868595005523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595005524 S-adenosylmethionine binding site [chemical binding]; other site 868595005525 chaperone protein DnaJ; Provisional; Region: PRK10767 868595005526 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 868595005527 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 868595005528 substrate binding site [polypeptide binding]; other site 868595005529 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 868595005530 Zn binding sites [ion binding]; other site 868595005531 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 868595005532 dimer interface [polypeptide binding]; other site 868595005533 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 868595005534 heat shock protein GrpE; Provisional; Region: PRK14140 868595005535 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 868595005536 dimer interface [polypeptide binding]; other site 868595005537 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 868595005538 chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309 868595005539 TCP-1/cpn60 chaperonin family; Region: Cpn60_TCP1; pfam00118 868595005540 ATP/Mg binding site [chemical binding]; other site 868595005541 ring oligomerisation interface [polypeptide binding]; other site 868595005542 hinge regions; other site 868595005543 stacking interactions; other site 868595005544 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 868595005545 HrcA protein C terminal domain; Region: HrcA; pfam01628 868595005546 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 868595005547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595005548 FeS/SAM binding site; other site 868595005549 HemN C-terminal domain; Region: HemN_C; pfam06969 868595005550 GTP-binding protein LepA; Provisional; Region: PRK05433 868595005551 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 868595005552 G1 box; other site 868595005553 putative GEF interaction site [polypeptide binding]; other site 868595005554 GTP/Mg2+ binding site [chemical binding]; other site 868595005555 Switch I region; other site 868595005556 G2 box; other site 868595005557 G3 box; other site 868595005558 Switch II region; other site 868595005559 G4 box; other site 868595005560 G5 box; other site 868595005561 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 868595005562 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 868595005563 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 868595005564 stage II sporulation protein P; Region: spore_II_P; TIGR02867 868595005565 Membrane protein of unknown function; Region: DUF360; cl00850 868595005566 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 868595005567 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 868595005568 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 868595005569 Domain of unknown function DUF77; Region: DUF77; cl00307 868595005570 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595005571 AMIN domain; Region: AMIN; pfam11741 868595005572 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 868595005573 active site 868595005574 metal binding site [ion binding]; metal-binding site 868595005575 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 868595005576 Competence protein; Region: Competence; cl00471 868595005577 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 868595005578 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 868595005579 N-acetyl-D-glucosamine binding site [chemical binding]; other site 868595005580 catalytic residue [active] 868595005581 SLBB domain; Region: SLBB; pfam10531 868595005582 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 868595005583 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 868595005584 Protein of unknown function (DUF421); Region: DUF421; cl00990 868595005585 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 868595005586 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 868595005587 HIGH motif; other site 868595005588 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 868595005589 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 868595005590 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 868595005591 active site 868595005592 KMSKS motif; other site 868595005593 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 868595005594 tRNA binding surface [nucleotide binding]; other site 868595005595 AMP-binding domain protein; Validated; Region: PRK08315 868595005596 AMP-binding enzyme; Region: AMP-binding; cl15778 868595005597 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 868595005598 Oligomerisation domain; Region: Oligomerisation; cl00519 868595005599 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 868595005600 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595005601 Zn2+ binding site [ion binding]; other site 868595005602 Mg2+ binding site [ion binding]; other site 868595005603 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 868595005604 RNA/DNA binding site [nucleotide binding]; other site 868595005605 RRM dimerization site [polypeptide binding]; other site 868595005606 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 868595005607 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 868595005608 active site 868595005609 (T/H)XGH motif; other site 868595005610 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 868595005611 nucleotide binding site/active site [active] 868595005612 HIT family signature motif; other site 868595005613 catalytic residue [active] 868595005614 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 868595005615 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 868595005616 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 868595005617 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 868595005618 ligand binding site [chemical binding]; other site 868595005619 dimerization interface [polypeptide binding]; other site 868595005620 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 868595005621 TM-ABC transporter signature motif; other site 868595005622 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 868595005623 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 868595005624 Walker A/P-loop; other site 868595005625 ATP binding site [chemical binding]; other site 868595005626 Q-loop/lid; other site 868595005627 ABC transporter signature motif; other site 868595005628 Walker B; other site 868595005629 D-loop; other site 868595005630 H-loop/switch region; other site 868595005631 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 868595005632 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 868595005633 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 868595005634 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 868595005635 substrate binding site [chemical binding]; other site 868595005636 dimer interface [polypeptide binding]; other site 868595005637 ATP binding site [chemical binding]; other site 868595005638 Transcriptional regulators [Transcription]; Region: PurR; COG1609 868595005639 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 868595005640 DNA binding site [nucleotide binding] 868595005641 domain linker motif; other site 868595005642 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 868595005643 dimerization interface [polypeptide binding]; other site 868595005644 ligand binding site [chemical binding]; other site 868595005645 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 868595005646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 868595005647 Integrase core domain; Region: rve; cl01316 868595005648 transposase/IS protein; Provisional; Region: PRK09183 868595005649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595005650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595005651 putative substrate translocation pore; other site 868595005652 Predicted RNA-binding protein; Region: RNA_bind_2; cl00662 868595005653 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 868595005654 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 868595005655 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 868595005656 Walker A/P-loop; other site 868595005657 ATP binding site [chemical binding]; other site 868595005658 Q-loop/lid; other site 868595005659 ABC transporter signature motif; other site 868595005660 Walker B; other site 868595005661 D-loop; other site 868595005662 H-loop/switch region; other site 868595005663 Cobalt transport protein; Region: CbiQ; cl00463 868595005664 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 868595005665 PDGLE domain; Region: PDGLE; cl07986 868595005666 benzoate transporter; Region: benE; TIGR00843 868595005667 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 868595005668 4Fe-4S binding domain; Region: Fer4; cl02805 868595005669 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 868595005670 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 868595005671 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 868595005672 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 868595005673 active site 868595005674 catalytic residues [active] 868595005675 metal binding site [ion binding]; metal-binding site 868595005676 DmpG-like communication domain; Region: DmpG_comm; pfam07836 868595005677 acetaldehyde dehydrogenase; Validated; Region: PRK08300 868595005678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595005679 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 868595005680 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 868595005681 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 868595005682 MPT binding site; other site 868595005683 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 868595005684 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 868595005685 active site 868595005686 Transcriptional regulator [Transcription]; Region: IclR; COG1414 868595005687 Helix-turn-helix domains; Region: HTH; cl00088 868595005688 Bacterial transcriptional regulator; Region: IclR; pfam01614 868595005689 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 868595005690 Flavoprotein; Region: Flavoprotein; cl08021 868595005691 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 868595005692 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 868595005693 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 868595005694 active site 868595005695 Protein of unknown function DUF111; Region: DUF111; cl03398 868595005696 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 868595005697 AIR carboxylase; Region: AIRC; cl00310 868595005698 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 868595005699 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 868595005700 Ligand Binding Site [chemical binding]; other site 868595005701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595005702 dimer interface [polypeptide binding]; other site 868595005703 putative CheW interface [polypeptide binding]; other site 868595005704 Ubiquitin-like proteins; Region: UBQ; cl00155 868595005705 charged pocket; other site 868595005706 hydrophobic patch; other site 868595005707 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 868595005708 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 868595005709 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 868595005710 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 868595005711 4Fe-4S binding domain; Region: Fer4; cl02805 868595005712 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 868595005713 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 868595005714 active site 868595005715 metal binding site [ion binding]; metal-binding site 868595005716 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 868595005717 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 868595005718 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 868595005719 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 868595005720 ligand binding site [chemical binding]; other site 868595005721 flexible hinge region; other site 868595005722 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 868595005723 putative switch regulator; other site 868595005724 non-specific DNA interactions [nucleotide binding]; other site 868595005725 DNA binding site [nucleotide binding] 868595005726 sequence specific DNA binding site [nucleotide binding]; other site 868595005727 putative cAMP binding site [chemical binding]; other site 868595005728 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 868595005729 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595005730 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 868595005731 active site 868595005732 substrate binding site [chemical binding]; other site 868595005733 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 868595005734 FMN binding site [chemical binding]; other site 868595005735 putative catalytic residues [active] 868595005736 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 868595005737 FOG: CBS domain [General function prediction only]; Region: COG0517 868595005738 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 868595005739 Flavin Reductases; Region: FlaRed; cl00801 868595005740 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 868595005741 dimer interface [polypeptide binding]; other site 868595005742 substrate binding site [chemical binding]; other site 868595005743 ATP binding site [chemical binding]; other site 868595005744 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 868595005745 Helix-turn-helix domains; Region: HTH; cl00088 868595005746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595005747 S-adenosylmethionine binding site [chemical binding]; other site 868595005748 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 868595005749 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 868595005750 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 868595005751 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 868595005752 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 868595005753 putative L-serine binding site [chemical binding]; other site 868595005754 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 868595005755 Helix-turn-helix domains; Region: HTH; cl00088 868595005756 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 868595005757 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 868595005758 AMP-binding enzyme; Region: AMP-binding; cl15778 868595005759 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 868595005760 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 868595005761 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 868595005762 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 868595005763 dimer interface [polypeptide binding]; other site 868595005764 PYR/PP interface [polypeptide binding]; other site 868595005765 TPP binding site [chemical binding]; other site 868595005766 substrate binding site [chemical binding]; other site 868595005767 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 868595005768 TPP-binding site; other site 868595005769 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 868595005770 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 868595005771 CPxP motif; other site 868595005772 selenophosphate synthetase; Provisional; Region: PRK00943 868595005773 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 868595005774 dimerization interface [polypeptide binding]; other site 868595005775 putative ATP binding site [chemical binding]; other site 868595005776 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 868595005777 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 868595005778 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 868595005779 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 868595005780 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 868595005781 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 868595005782 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 868595005783 oligomeric interface; other site 868595005784 putative active site [active] 868595005785 homodimer interface [polypeptide binding]; other site 868595005786 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 868595005787 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 868595005788 putative phosphate binding site [ion binding]; other site 868595005789 putative catalytic site [active] 868595005790 active site 868595005791 metal binding site A [ion binding]; metal-binding site 868595005792 DNA binding site [nucleotide binding] 868595005793 putative AP binding site [nucleotide binding]; other site 868595005794 putative metal binding site B [ion binding]; other site 868595005795 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 868595005796 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 868595005797 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 868595005798 Uncharacterized conserved protein [Function unknown]; Region: COG1751 868595005799 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 868595005800 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595005801 dimer interface [polypeptide binding]; other site 868595005802 putative CheW interface [polypeptide binding]; other site 868595005803 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 868595005804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 868595005805 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 868595005806 Ion channel; Region: Ion_trans_2; cl11596 868595005807 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 868595005808 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 868595005809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595005810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 868595005811 Coenzyme A binding pocket [chemical binding]; other site 868595005812 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 868595005813 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 868595005814 ACS interaction site; other site 868595005815 CODH interaction site; other site 868595005816 cubane metal cluster (B-cluster) [ion binding]; other site 868595005817 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 868595005818 gamma-glutamyl kinase; Provisional; Region: PRK05429 868595005819 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 868595005820 nucleotide binding site [chemical binding]; other site 868595005821 homotetrameric interface [polypeptide binding]; other site 868595005822 putative phosphate binding site [ion binding]; other site 868595005823 putative allosteric binding site; other site 868595005824 PUA domain; Region: PUA; cl00607 868595005825 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 868595005826 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 868595005827 putative catalytic cysteine [active] 868595005828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595005829 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 868595005830 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595005831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595005832 metal binding site [ion binding]; metal-binding site 868595005833 active site 868595005834 I-site; other site 868595005835 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 868595005836 dimer interface [polypeptide binding]; other site 868595005837 [2Fe-2S] cluster binding site [ion binding]; other site 868595005838 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 868595005839 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 868595005840 SLBB domain; Region: SLBB; pfam10531 868595005841 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 868595005842 4Fe-4S binding domain; Region: Fer4; cl02805 868595005843 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595005844 4Fe-4S binding domain; Region: Fer4; cl02805 868595005845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 868595005846 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 868595005847 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 868595005848 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595005849 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595005850 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 868595005851 aspartate kinase; Reviewed; Region: PRK06635 868595005852 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 868595005853 putative nucleotide binding site [chemical binding]; other site 868595005854 putative catalytic residues [active] 868595005855 putative Mg ion binding site [ion binding]; other site 868595005856 putative aspartate binding site [chemical binding]; other site 868595005857 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 868595005858 putative allosteric regulatory site; other site 868595005859 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 868595005860 putative allosteric regulatory residue; other site 868595005861 homoserine kinase; Provisional; Region: PRK01212 868595005862 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 868595005863 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 868595005864 homoserine dehydrogenase; Provisional; Region: PRK06349 868595005865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595005866 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 868595005867 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 868595005868 hypothetical protein; Provisional; Region: PRK04435 868595005869 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 868595005870 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 868595005871 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 868595005872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595005873 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 868595005874 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 868595005875 GTP-binding protein Der; Reviewed; Region: PRK00093 868595005876 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 868595005877 G1 box; other site 868595005878 GTP/Mg2+ binding site [chemical binding]; other site 868595005879 Switch I region; other site 868595005880 G2 box; other site 868595005881 Switch II region; other site 868595005882 G3 box; other site 868595005883 G4 box; other site 868595005884 G5 box; other site 868595005885 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 868595005886 G1 box; other site 868595005887 GTP/Mg2+ binding site [chemical binding]; other site 868595005888 Switch I region; other site 868595005889 G2 box; other site 868595005890 G3 box; other site 868595005891 Switch II region; other site 868595005892 G4 box; other site 868595005893 G5 box; other site 868595005894 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 868595005895 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 868595005896 Protein of unknown function (DUF512); Region: DUF512; pfam04459 868595005897 YIEGIA protein; Region: YIEGIA; pfam14045 868595005898 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 868595005899 stage II sporulation protein P; Region: spore_II_P; TIGR02867 868595005900 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 868595005901 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 868595005902 LytB protein; Region: LYTB; cl00507 868595005903 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 868595005904 RNA binding site [nucleotide binding]; other site 868595005905 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 868595005906 RNA binding site [nucleotide binding]; other site 868595005907 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 868595005908 RNA binding site [nucleotide binding]; other site 868595005909 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 868595005910 RNA binding site [nucleotide binding]; other site 868595005911 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 868595005912 putative acyl-acceptor binding pocket; other site 868595005913 cytidylate kinase; Provisional; Region: cmk; PRK00023 868595005914 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 868595005915 CMP-binding site; other site 868595005916 The sites determining sugar specificity; other site 868595005917 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 868595005918 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 868595005919 hinge; other site 868595005920 active site 868595005921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595005922 Prephenate dehydrogenase; Region: PDH; pfam02153 868595005923 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 868595005924 NeuB family; Region: NeuB; cl00496 868595005925 aspartate aminotransferase; Provisional; Region: PRK06836 868595005926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595005927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595005928 homodimer interface [polypeptide binding]; other site 868595005929 catalytic residue [active] 868595005930 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 868595005931 homotrimer interaction site [polypeptide binding]; other site 868595005932 active site 868595005933 HutP; Region: HutP; cl07944 868595005934 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 868595005935 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 868595005936 RNA binding surface [nucleotide binding]; other site 868595005937 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 868595005938 active site 868595005939 Nucleoside recognition; Region: Gate; cl00486 868595005940 Nucleoside recognition; Region: Gate; cl00486 868595005941 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 868595005942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 868595005943 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 868595005944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595005945 dimer interface [polypeptide binding]; other site 868595005946 phosphorylation site [posttranslational modification] 868595005947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595005948 ATP binding site [chemical binding]; other site 868595005949 G-X-G motif; other site 868595005950 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 868595005951 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 868595005952 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 868595005953 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 868595005954 ScpA/B protein; Region: ScpA_ScpB; cl00598 868595005955 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 868595005956 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 868595005957 active site 868595005958 HIGH motif; other site 868595005959 dimer interface [polypeptide binding]; other site 868595005960 KMSKS motif; other site 868595005961 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 868595005962 active site 868595005963 putative substrate binding region [chemical binding]; other site 868595005964 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 868595005965 DHH family; Region: DHH; pfam01368 868595005966 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 868595005967 FOG: CBS domain [General function prediction only]; Region: COG0517 868595005968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 868595005969 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 868595005970 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 868595005971 active site 868595005972 NTP binding site [chemical binding]; other site 868595005973 metal binding triad [ion binding]; metal-binding site 868595005974 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 868595005975 diaminopimelate decarboxylase; Region: lysA; TIGR01048 868595005976 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 868595005977 active site 868595005978 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 868595005979 substrate binding site [chemical binding]; other site 868595005980 catalytic residues [active] 868595005981 dimer interface [polypeptide binding]; other site 868595005982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595005983 non-specific DNA binding site [nucleotide binding]; other site 868595005984 salt bridge; other site 868595005985 sequence-specific DNA binding site [nucleotide binding]; other site 868595005986 Domain of unknown function (DUF955); Region: DUF955; cl01076 868595005987 EamA-like transporter family; Region: EamA; cl01037 868595005988 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 868595005989 EamA-like transporter family; Region: EamA; cl01037 868595005990 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 868595005991 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 868595005992 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 868595005993 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 868595005994 RNA binding site [nucleotide binding]; other site 868595005995 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 868595005996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 868595005997 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 868595005998 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 868595005999 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 868595006000 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 868595006001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595006002 catalytic loop [active] 868595006003 iron binding site [ion binding]; other site 868595006004 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 868595006005 4Fe-4S binding domain; Region: Fer4; cl02805 868595006006 4Fe-4S binding domain; Region: Fer4; cl02805 868595006007 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 868595006008 [4Fe-4S] binding site [ion binding]; other site 868595006009 molybdopterin cofactor binding site; other site 868595006010 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 868595006011 molybdopterin cofactor binding site; other site 868595006012 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 868595006013 dimer interface [polypeptide binding]; other site 868595006014 [2Fe-2S] cluster binding site [ion binding]; other site 868595006015 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 868595006016 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 868595006017 SLBB domain; Region: SLBB; pfam10531 868595006018 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 868595006019 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 868595006020 4Fe-4S binding domain; Region: Fer4; cl02805 868595006021 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 868595006022 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 868595006023 putative dimer interface [polypeptide binding]; other site 868595006024 [2Fe-2S] cluster binding site [ion binding]; other site 868595006025 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 868595006026 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 868595006027 Polysulphide reductase, NrfD; Region: NrfD; cl01295 868595006028 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 868595006029 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 868595006030 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 868595006031 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 868595006032 [4Fe-4S] binding site [ion binding]; other site 868595006033 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 868595006034 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 868595006035 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 868595006036 molybdopterin cofactor binding site; other site 868595006037 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 868595006038 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 868595006039 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 868595006040 GTP binding site; other site 868595006041 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 868595006042 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 868595006043 sporulation sigma factor SigF; Validated; Region: PRK05572 868595006044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595006045 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 868595006046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595006047 DNA binding residues [nucleotide binding] 868595006048 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 868595006049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595006050 ATP binding site [chemical binding]; other site 868595006051 Mg2+ binding site [ion binding]; other site 868595006052 G-X-G motif; other site 868595006053 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 868595006054 anti sigma factor interaction site; other site 868595006055 regulatory phosphorylation site [posttranslational modification]; other site 868595006056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 868595006057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595006058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 868595006059 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 868595006060 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 868595006061 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 868595006062 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 868595006063 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 868595006064 Sulfatase; Region: Sulfatase; cl10460 868595006065 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 868595006066 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 868595006067 Int/Topo IB signature motif; other site 868595006068 active site 868595006069 Protein of unknown function (DUF441); Region: DUF441; cl01041 868595006070 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 868595006071 Integral membrane protein DUF95; Region: DUF95; cl00572 868595006072 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 868595006073 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 868595006074 peptidase T-like protein; Region: PepT-like; TIGR01883 868595006075 metal binding site [ion binding]; metal-binding site 868595006076 putative dimer interface [polypeptide binding]; other site 868595006077 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 868595006078 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 868595006079 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 868595006080 TPP-binding site [chemical binding]; other site 868595006081 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 868595006082 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 868595006083 dimer interface [polypeptide binding]; other site 868595006084 PYR/PP interface [polypeptide binding]; other site 868595006085 TPP binding site [chemical binding]; other site 868595006086 substrate binding site [chemical binding]; other site 868595006087 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595006088 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595006089 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 868595006090 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595006091 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 868595006092 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 868595006093 putative catalytic motif [active] 868595006094 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 868595006095 Ligand binding site; other site 868595006096 Putative Catalytic site; other site 868595006097 DXD motif; other site 868595006098 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 868595006099 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 868595006100 Thiamine pyrophosphokinase; Region: TPK; cl08415 868595006101 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 868595006102 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 868595006103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595006104 active site 868595006105 phosphorylation site [posttranslational modification] 868595006106 intermolecular recognition site; other site 868595006107 dimerization interface [polypeptide binding]; other site 868595006108 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 868595006109 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 868595006110 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 868595006111 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 868595006112 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 868595006113 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 868595006114 Walker A/P-loop; other site 868595006115 ATP binding site [chemical binding]; other site 868595006116 Q-loop/lid; other site 868595006117 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 868595006118 ABC transporter signature motif; other site 868595006119 Walker B; other site 868595006120 D-loop; other site 868595006121 H-loop/switch region; other site 868595006122 arginine repressor; Provisional; Region: PRK04280 868595006123 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 868595006124 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 868595006125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006127 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 868595006128 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 868595006129 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 868595006130 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 868595006131 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595006132 RNA binding surface [nucleotide binding]; other site 868595006133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 868595006134 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 868595006135 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595006136 Walker A/P-loop; other site 868595006137 ATP binding site [chemical binding]; other site 868595006138 Q-loop/lid; other site 868595006139 ABC transporter signature motif; other site 868595006140 Walker B; other site 868595006141 D-loop; other site 868595006142 H-loop/switch region; other site 868595006143 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 868595006144 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 868595006145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595006146 Walker A/P-loop; other site 868595006147 ATP binding site [chemical binding]; other site 868595006148 Q-loop/lid; other site 868595006149 ABC transporter signature motif; other site 868595006150 Walker B; other site 868595006151 D-loop; other site 868595006152 H-loop/switch region; other site 868595006153 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 868595006154 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 868595006155 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 868595006156 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 868595006157 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 868595006158 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 868595006159 TPP-binding site; other site 868595006160 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 868595006161 PYR/PP interface [polypeptide binding]; other site 868595006162 dimer interface [polypeptide binding]; other site 868595006163 TPP binding site [chemical binding]; other site 868595006164 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 868595006165 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 868595006166 substrate binding pocket [chemical binding]; other site 868595006167 chain length determination region; other site 868595006168 substrate-Mg2+ binding site; other site 868595006169 catalytic residues [active] 868595006170 aspartate-rich region 1; other site 868595006171 active site lid residues [active] 868595006172 aspartate-rich region 2; other site 868595006173 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 868595006174 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 868595006175 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 868595006176 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 868595006177 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 868595006178 homodimer interface [polypeptide binding]; other site 868595006179 NADP binding site [chemical binding]; other site 868595006180 substrate binding site [chemical binding]; other site 868595006181 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 868595006182 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 868595006183 generic binding surface II; other site 868595006184 generic binding surface I; other site 868595006185 putative oxidoreductase; Provisional; Region: PRK12831 868595006186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595006188 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 868595006189 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 868595006190 FAD binding pocket [chemical binding]; other site 868595006191 FAD binding motif [chemical binding]; other site 868595006192 phosphate binding motif [ion binding]; other site 868595006193 beta-alpha-beta structure motif; other site 868595006194 NAD binding pocket [chemical binding]; other site 868595006195 Iron coordination center [ion binding]; other site 868595006196 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 868595006197 putative RNA binding site [nucleotide binding]; other site 868595006198 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 868595006199 Asp23 family; Region: Asp23; cl00574 868595006200 Asp23 family; Region: Asp23; cl00574 868595006201 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 868595006202 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 868595006203 ATP-grasp domain; Region: ATP-grasp_4; cl03087 868595006204 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 868595006205 pyruvate carboxylase subunit B; Validated; Region: PRK09282 868595006206 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 868595006207 active site 868595006208 catalytic residues [active] 868595006209 metal binding site [ion binding]; metal-binding site 868595006210 homodimer binding site [polypeptide binding]; other site 868595006211 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 868595006212 carboxyltransferase (CT) interaction site; other site 868595006213 biotinylation site [posttranslational modification]; other site 868595006214 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 868595006215 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 868595006216 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 868595006217 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 868595006218 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 868595006219 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 868595006220 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 868595006221 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 868595006222 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595006223 Walker A motif; other site 868595006224 ATP binding site [chemical binding]; other site 868595006225 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595006226 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 868595006227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595006228 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 868595006229 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 868595006230 active site residue [active] 868595006231 elongation factor P; Validated; Region: PRK00529 868595006232 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 868595006233 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 868595006234 RNA binding site [nucleotide binding]; other site 868595006235 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 868595006236 RNA binding site [nucleotide binding]; other site 868595006237 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 868595006238 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 868595006239 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 868595006240 active site 868595006241 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 868595006242 trimer interface [polypeptide binding]; other site 868595006243 active site 868595006244 dimer interface [polypeptide binding]; other site 868595006245 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 868595006246 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 868595006247 LrgB-like family; Region: LrgB; cl00596 868595006248 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 868595006249 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595006250 putative active site [active] 868595006251 putative metal binding site [ion binding]; other site 868595006252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595006253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595006254 putative substrate translocation pore; other site 868595006255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595006256 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 868595006257 Helix-turn-helix domains; Region: HTH; cl00088 868595006258 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 868595006259 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 868595006260 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 868595006261 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 868595006262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006263 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 868595006264 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 868595006265 Walker A/P-loop; other site 868595006266 ATP binding site [chemical binding]; other site 868595006267 Q-loop/lid; other site 868595006268 ABC transporter signature motif; other site 868595006269 Walker B; other site 868595006270 D-loop; other site 868595006271 H-loop/switch region; other site 868595006272 NIL domain; Region: NIL; cl09633 868595006273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595006274 dimer interface [polypeptide binding]; other site 868595006275 conserved gate region; other site 868595006276 ABC-ATPase subunit interface; other site 868595006277 NMT1-like family; Region: NMT1_2; cl15260 868595006278 sporulation sigma factor SigK; Reviewed; Region: PRK05803 868595006279 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595006280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595006281 DNA binding residues [nucleotide binding] 868595006282 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 868595006283 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 868595006284 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 868595006285 Phosphate transporter family; Region: PHO4; cl00396 868595006286 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 868595006287 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 868595006288 Helix-turn-helix domains; Region: HTH; cl00088 868595006289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595006290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595006291 putative substrate translocation pore; other site 868595006292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595006293 Zn2+ binding site [ion binding]; other site 868595006294 Mg2+ binding site [ion binding]; other site 868595006295 Predicted permeases [General function prediction only]; Region: RarD; COG2962 868595006296 agmatine deiminase; Region: agmatine_aguA; TIGR03380 868595006297 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 868595006298 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595006299 MULE transposase domain; Region: MULE; pfam10551 868595006300 DsrE/DsrF-like family; Region: DrsE; cl00672 868595006301 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 868595006302 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 868595006303 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 868595006304 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 868595006305 5S rRNA interface [nucleotide binding]; other site 868595006306 CTC domain interface [polypeptide binding]; other site 868595006307 L16 interface [polypeptide binding]; other site 868595006308 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 868595006309 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 868595006310 active site 868595006311 substrate binding site [chemical binding]; other site 868595006312 metal binding site [ion binding]; metal-binding site 868595006313 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 868595006314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 868595006315 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 868595006316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595006317 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 868595006318 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 868595006319 active site 868595006320 Substrate binding site; other site 868595006321 Mg++ binding site; other site 868595006322 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 868595006323 Domain of unknown function (DUF377); Region: DUF377; pfam04041 868595006324 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 868595006325 active site 868595006326 DNA polymerase IV; Reviewed; Region: PRK03103 868595006327 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 868595006328 active site 868595006329 DNA binding site [nucleotide binding] 868595006330 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 868595006331 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 868595006332 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 868595006333 putative dimer interface [polypeptide binding]; other site 868595006334 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 868595006335 YabG peptidase U57; Region: Peptidase_U57; cl05250 868595006336 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 868595006337 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 868595006338 Pilus assembly protein, PilO; Region: PilO; cl01234 868595006339 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 868595006340 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 868595006341 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 868595006342 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 868595006343 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 868595006344 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 868595006345 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 868595006346 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 868595006347 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 868595006348 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 868595006349 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 868595006350 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595006351 Walker A motif; other site 868595006352 ATP binding site [chemical binding]; other site 868595006353 Walker B motif; other site 868595006354 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 868595006355 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 868595006356 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 868595006357 Walker A motif; other site 868595006358 ATP binding site [chemical binding]; other site 868595006359 Walker B motif; other site 868595006360 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 868595006361 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 868595006362 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 868595006363 active site 868595006364 dimer interface [polypeptide binding]; other site 868595006365 metal binding site [ion binding]; metal-binding site 868595006366 shikimate kinase; Provisional; Region: PRK13947 868595006367 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 868595006368 ADP binding site [chemical binding]; other site 868595006369 magnesium binding site [ion binding]; other site 868595006370 putative shikimate binding site; other site 868595006371 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 868595006372 Tetramer interface [polypeptide binding]; other site 868595006373 active site 868595006374 FMN-binding site [chemical binding]; other site 868595006375 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 868595006376 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 868595006377 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 868595006378 shikimate binding site; other site 868595006379 NAD(P) binding site [chemical binding]; other site 868595006380 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 868595006381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595006382 active site 868595006383 motif I; other site 868595006384 motif II; other site 868595006385 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595006386 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 868595006387 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 868595006388 catalytic residues [active] 868595006389 catalytic nucleophile [active] 868595006390 Recombinase; Region: Recombinase; pfam07508 868595006391 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 868595006392 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 868595006393 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595006394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 868595006395 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 868595006396 IHF - DNA interface [nucleotide binding]; other site 868595006397 IHF dimer interface [polypeptide binding]; other site 868595006398 HEPN domain; Region: HEPN; cl00824 868595006399 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 868595006400 active site 868595006401 NTP binding site [chemical binding]; other site 868595006402 metal binding triad [ion binding]; metal-binding site 868595006403 antibiotic binding site [chemical binding]; other site 868595006404 Replication-relaxation; Region: Replic_Relax; pfam13814 868595006405 Replication-relaxation; Region: Replic_Relax; pfam13814 868595006406 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 868595006407 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 868595006408 Helix-turn-helix domains; Region: HTH; cl00088 868595006409 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 868595006410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595006411 metal binding site [ion binding]; metal-binding site 868595006412 active site 868595006413 I-site; other site 868595006414 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595006415 Zn2+ binding site [ion binding]; other site 868595006416 Mg2+ binding site [ion binding]; other site 868595006417 Accessory gene regulator B; Region: AgrB; cl01873 868595006418 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 868595006419 Helix-turn-helix domains; Region: HTH; cl00088 868595006420 Integrase core domain; Region: rve; cl01316 868595006421 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 868595006422 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 868595006423 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 868595006424 catalytic residues [active] 868595006425 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 868595006426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595006427 non-specific DNA binding site [nucleotide binding]; other site 868595006428 salt bridge; other site 868595006429 sequence-specific DNA binding site [nucleotide binding]; other site 868595006430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595006431 non-specific DNA binding site [nucleotide binding]; other site 868595006432 salt bridge; other site 868595006433 sequence-specific DNA binding site [nucleotide binding]; other site 868595006434 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 868595006435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595006436 non-specific DNA binding site [nucleotide binding]; other site 868595006437 salt bridge; other site 868595006438 sequence-specific DNA binding site [nucleotide binding]; other site 868595006439 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 868595006440 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 868595006441 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595006442 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 868595006443 Peptidase family U32; Region: Peptidase_U32; cl03113 868595006444 YceG-like family; Region: YceG; pfam02618 868595006445 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 868595006446 dimerization interface [polypeptide binding]; other site 868595006447 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 868595006448 Rrf2 family protein; Region: rrf2_super; TIGR00738 868595006449 Helix-turn-helix domains; Region: HTH; cl00088 868595006450 FAD binding domain; Region: FAD_binding_4; pfam01565 868595006451 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 868595006452 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 868595006453 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 868595006454 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 868595006455 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 868595006456 Ligand binding site [chemical binding]; other site 868595006457 Electron transfer flavoprotein domain; Region: ETF; pfam01012 868595006458 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 868595006459 VanW like protein; Region: VanW; pfam04294 868595006460 G5 domain; Region: G5; pfam07501 868595006461 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 868595006462 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 868595006463 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 868595006464 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 868595006465 active site 868595006466 catalytic tetrad [active] 868595006467 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 868595006468 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 868595006469 intracellular protease, PfpI family; Region: PfpI; TIGR01382 868595006470 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 868595006471 conserved cys residue [active] 868595006472 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 868595006473 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 868595006474 motif 1; other site 868595006475 active site 868595006476 motif 2; other site 868595006477 motif 3; other site 868595006478 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 868595006479 DHHA1 domain; Region: DHHA1; pfam02272 868595006480 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 868595006481 Domain of unknown function DUF20; Region: UPF0118; pfam01594 868595006482 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 868595006483 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 868595006484 Ligand Binding Site [chemical binding]; other site 868595006485 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 868595006486 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 868595006487 trimerization site [polypeptide binding]; other site 868595006488 active site 868595006489 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 868595006490 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 868595006491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 868595006492 catalytic residue [active] 868595006493 Helix-turn-helix domains; Region: HTH; cl00088 868595006494 Rrf2 family protein; Region: rrf2_super; TIGR00738 868595006495 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 868595006496 catalytic residues [active] 868595006497 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 868595006498 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 868595006499 putative ATP binding site [chemical binding]; other site 868595006500 putative substrate interface [chemical binding]; other site 868595006501 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 868595006502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595006503 dimerization interface [polypeptide binding]; other site 868595006504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595006505 dimer interface [polypeptide binding]; other site 868595006506 phosphorylation site [posttranslational modification] 868595006507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595006508 ATP binding site [chemical binding]; other site 868595006509 Mg2+ binding site [ion binding]; other site 868595006510 G-X-G motif; other site 868595006511 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595006512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595006513 active site 868595006514 phosphorylation site [posttranslational modification] 868595006515 intermolecular recognition site; other site 868595006516 dimerization interface [polypeptide binding]; other site 868595006517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595006518 DNA binding site [nucleotide binding] 868595006519 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 868595006520 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 868595006521 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 868595006522 protein binding site [polypeptide binding]; other site 868595006523 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 868595006524 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 868595006525 dimer interface [polypeptide binding]; other site 868595006526 anticodon binding site; other site 868595006527 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 868595006528 homodimer interface [polypeptide binding]; other site 868595006529 motif 1; other site 868595006530 active site 868595006531 motif 2; other site 868595006532 GAD domain; Region: GAD; pfam02938 868595006533 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 868595006534 motif 3; other site 868595006535 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 868595006536 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 868595006537 dimer interface [polypeptide binding]; other site 868595006538 motif 1; other site 868595006539 active site 868595006540 motif 2; other site 868595006541 motif 3; other site 868595006542 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 868595006543 anticodon binding site; other site 868595006544 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 868595006545 GAF domain; Region: GAF; cl15785 868595006546 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595006547 metal binding site [ion binding]; metal-binding site 868595006548 active site 868595006549 I-site; other site 868595006550 Sensory domain found in PocR; Region: PocR; pfam10114 868595006551 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595006552 KaiC domain protein, Ph0284 family; Region: thermo_KaiC_1; TIGR03877 868595006553 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595006554 ATP binding site [chemical binding]; other site 868595006555 Walker B motif; other site 868595006556 D-allose kinase; Provisional; Region: PRK09698 868595006557 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595006558 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595006559 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595006560 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 868595006561 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 868595006562 GAF domain; Region: GAF; cl15785 868595006563 Histidine kinase; Region: His_kinase; pfam06580 868595006564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595006565 ATP binding site [chemical binding]; other site 868595006566 Mg2+ binding site [ion binding]; other site 868595006567 G-X-G motif; other site 868595006568 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 868595006569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006570 NAD(P) binding site [chemical binding]; other site 868595006571 active site 868595006572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 868595006573 Helix-turn-helix domains; Region: HTH; cl00088 868595006574 Predicted membrane protein [Function unknown]; Region: COG1511 868595006575 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 868595006576 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 868595006577 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 868595006578 ABC-2 type transporter; Region: ABC2_membrane; cl11417 868595006579 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 868595006580 Spore germination protein; Region: Spore_permease; cl15802 868595006581 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 868595006582 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595006583 active site 868595006584 metal binding site [ion binding]; metal-binding site 868595006585 homotetramer interface [polypeptide binding]; other site 868595006586 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 868595006587 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 868595006588 putative active site [active] 868595006589 dimerization interface [polypeptide binding]; other site 868595006590 putative tRNAtyr binding site [nucleotide binding]; other site 868595006591 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595006592 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595006593 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595006594 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595006595 DNA binding residues [nucleotide binding] 868595006596 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595006597 catalytic residues [active] 868595006598 catalytic nucleophile [active] 868595006599 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 868595006600 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 868595006601 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 868595006602 synthetase active site [active] 868595006603 NTP binding site [chemical binding]; other site 868595006604 metal binding site [ion binding]; metal-binding site 868595006605 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 868595006606 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 868595006607 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595006608 active site 868595006609 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 868595006610 DHH family; Region: DHH; pfam01368 868595006611 DHHA1 domain; Region: DHHA1; pfam02272 868595006612 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 868595006613 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 868595006614 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 868595006615 Walker A/P-loop; other site 868595006616 ATP binding site [chemical binding]; other site 868595006617 Q-loop/lid; other site 868595006618 ABC transporter signature motif; other site 868595006619 Walker B; other site 868595006620 D-loop; other site 868595006621 H-loop/switch region; other site 868595006622 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 868595006623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595006624 dimer interface [polypeptide binding]; other site 868595006625 conserved gate region; other site 868595006626 putative PBP binding loops; other site 868595006627 ABC-ATPase subunit interface; other site 868595006628 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 868595006629 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 868595006630 substrate binding pocket [chemical binding]; other site 868595006631 membrane-bound complex binding site; other site 868595006632 hinge residues; other site 868595006633 EamA-like transporter family; Region: EamA; cl01037 868595006634 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 868595006635 EamA-like transporter family; Region: EamA; cl01037 868595006636 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 868595006637 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 868595006638 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 868595006639 Cation efflux family; Region: Cation_efflux; cl00316 868595006640 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 868595006641 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 868595006642 tetramer interface [polypeptide binding]; other site 868595006643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595006644 catalytic residue [active] 868595006645 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 868595006646 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 868595006647 tetramer interface [polypeptide binding]; other site 868595006648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595006649 catalytic residue [active] 868595006650 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 868595006651 lipoyl attachment site [posttranslational modification]; other site 868595006652 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 868595006653 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 868595006654 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 868595006655 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 868595006656 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 868595006657 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 868595006658 HIGH motif; other site 868595006659 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 868595006660 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 868595006661 active site 868595006662 KMSKS motif; other site 868595006663 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 868595006664 tRNA binding surface [nucleotide binding]; other site 868595006665 anticodon binding site; other site 868595006666 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 868595006667 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 868595006668 DivIVA protein; Region: DivIVA; pfam05103 868595006669 DivIVA domain; Region: DivI1A_domain; TIGR03544 868595006670 Plant ATP synthase F0; Region: YMF19; cl07975 868595006671 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 868595006672 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595006673 RNA binding surface [nucleotide binding]; other site 868595006674 YGGT family; Region: YGGT; cl00508 868595006675 Protein of unknown function (DUF552); Region: DUF552; cl00775 868595006676 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 868595006677 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 868595006678 catalytic residue [active] 868595006679 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 868595006680 lipoyl-biotinyl attachment site [posttranslational modification]; other site 868595006681 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 868595006682 Recombinase; Region: Recombinase; pfam07508 868595006683 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 868595006684 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 868595006685 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 868595006686 Integrase core domain; Region: rve; cl01316 868595006687 Integrase core domain; Region: rve_3; cl15866 868595006688 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 868595006689 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 868595006690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595006691 Walker A motif; other site 868595006692 ATP binding site [chemical binding]; other site 868595006693 Walker B motif; other site 868595006694 arginine finger; other site 868595006695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595006696 non-specific DNA binding site [nucleotide binding]; other site 868595006697 salt bridge; other site 868595006698 sequence-specific DNA binding site [nucleotide binding]; other site 868595006699 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 868595006700 HsdM N-terminal domain; Region: HsdM_N; pfam12161 868595006701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006702 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 868595006703 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 868595006704 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 868595006705 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 868595006706 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 868595006707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595006708 ATP binding site [chemical binding]; other site 868595006709 putative Mg++ binding site [ion binding]; other site 868595006710 Abortive infection C-terminus; Region: Abi_C; pfam14355 868595006711 sodium/calcium exchanger 1; Region: caca; TIGR00845 868595006712 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 868595006713 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 868595006714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 868595006715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595006716 dimer interface [polypeptide binding]; other site 868595006717 phosphorylation site [posttranslational modification] 868595006718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595006719 ATP binding site [chemical binding]; other site 868595006720 Mg2+ binding site [ion binding]; other site 868595006721 G-X-G motif; other site 868595006722 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595006723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595006724 active site 868595006725 phosphorylation site [posttranslational modification] 868595006726 intermolecular recognition site; other site 868595006727 dimerization interface [polypeptide binding]; other site 868595006728 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595006729 DNA binding site [nucleotide binding] 868595006730 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 868595006731 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 868595006732 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 868595006733 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 868595006734 Beta-Casp domain; Region: Beta-Casp; cl12567 868595006735 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 868595006736 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 868595006737 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595006738 putative peptidoglycan binding site; other site 868595006739 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 868595006740 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 868595006741 ResB-like family; Region: ResB; pfam05140 868595006742 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 868595006743 Cytochrome c552; Region: Cytochrom_C552; pfam02335 868595006744 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 868595006745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595006746 S-adenosylmethionine binding site [chemical binding]; other site 868595006747 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 868595006748 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 868595006749 ligand binding site [chemical binding]; other site 868595006750 flexible hinge region; other site 868595006751 Helix-turn-helix domains; Region: HTH; cl00088 868595006752 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 868595006753 4Fe-4S binding domain; Region: Fer4; cl02805 868595006754 Copper resistance protein D; Region: CopD; cl00563 868595006755 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 868595006756 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 868595006757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595006758 FeS/SAM binding site; other site 868595006759 ATP cone domain; Region: ATP-cone; pfam03477 868595006760 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 868595006761 Class III ribonucleotide reductase; Region: RNR_III; cd01675 868595006762 effector binding site; other site 868595006763 active site 868595006764 Zn binding site [ion binding]; other site 868595006765 glycine loop; other site 868595006766 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 868595006767 ATP cone domain; Region: ATP-cone; pfam03477 868595006768 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 868595006769 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 868595006770 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 868595006771 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 868595006772 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595006773 Cysteine-rich domain; Region: CCG; pfam02754 868595006774 Cysteine-rich domain; Region: CCG; pfam02754 868595006775 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 868595006776 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 868595006777 sporulation sigma factor SigG; Reviewed; Region: PRK08215 868595006778 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595006779 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 868595006780 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595006781 DNA binding residues [nucleotide binding] 868595006782 sporulation sigma factor SigE; Reviewed; Region: PRK08301 868595006783 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595006784 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595006785 DNA binding residues [nucleotide binding] 868595006786 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 868595006787 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 868595006788 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 868595006789 cell division protein FtsZ; Validated; Region: PRK09330 868595006790 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 868595006791 nucleotide binding site [chemical binding]; other site 868595006792 SulA interaction site; other site 868595006793 Cell division protein FtsA; Region: FtsA; cl11496 868595006794 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 868595006795 Cell division protein FtsA; Region: FtsA; cl11496 868595006796 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 868595006797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 868595006798 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 868595006799 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 868595006800 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 868595006801 Cell division protein FtsQ; Region: FtsQ; pfam03799 868595006802 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 868595006803 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 868595006804 hinge; other site 868595006805 active site 868595006806 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 868595006807 FAD binding domain; Region: FAD_binding_4; pfam01565 868595006808 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 868595006809 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 868595006810 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 868595006811 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595006812 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 868595006813 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 868595006814 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 868595006815 active site 868595006816 homodimer interface [polypeptide binding]; other site 868595006817 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 868595006818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006819 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 868595006820 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595006821 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 868595006822 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 868595006823 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 868595006824 Mg++ binding site [ion binding]; other site 868595006825 putative catalytic motif [active] 868595006826 putative substrate binding site [chemical binding]; other site 868595006827 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 868595006828 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 868595006829 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595006830 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 868595006831 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 868595006832 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 868595006833 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595006834 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 868595006835 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 868595006836 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 868595006837 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595006838 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 868595006839 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 868595006840 Septum formation initiator; Region: DivIC; cl11433 868595006841 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 868595006842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006843 cell division protein MraZ; Reviewed; Region: PRK00326 868595006844 MraZ protein; Region: MraZ; pfam02381 868595006845 MraZ protein; Region: MraZ; pfam02381 868595006846 histidinol-phosphatase; Provisional; Region: PRK07328 868595006847 PHP-associated; Region: PHP_C; pfam13263 868595006848 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 868595006849 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 868595006850 active site 868595006851 nucleophile elbow; other site 868595006852 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 868595006853 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 868595006854 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595006855 putative active site [active] 868595006856 heme pocket [chemical binding]; other site 868595006857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595006858 Walker A motif; other site 868595006859 ATP binding site [chemical binding]; other site 868595006860 Walker B motif; other site 868595006861 arginine finger; other site 868595006862 FeoA domain; Region: FeoA; cl00838 868595006863 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 868595006864 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 868595006865 G1 box; other site 868595006866 GTP/Mg2+ binding site [chemical binding]; other site 868595006867 Switch I region; other site 868595006868 G2 box; other site 868595006869 G3 box; other site 868595006870 Switch II region; other site 868595006871 G4 box; other site 868595006872 G5 box; other site 868595006873 Nucleoside recognition; Region: Gate; cl00486 868595006874 Nucleoside recognition; Region: Gate; cl00486 868595006875 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 868595006876 metal binding site 2 [ion binding]; metal-binding site 868595006877 putative DNA binding helix; other site 868595006878 metal binding site 1 [ion binding]; metal-binding site 868595006879 dimer interface [polypeptide binding]; other site 868595006880 structural Zn2+ binding site [ion binding]; other site 868595006881 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 868595006882 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 868595006883 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 868595006884 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 868595006885 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 868595006886 G1 box; other site 868595006887 GTP/Mg2+ binding site [chemical binding]; other site 868595006888 Switch I region; other site 868595006889 G2 box; other site 868595006890 G3 box; other site 868595006891 Switch II region; other site 868595006892 G4 box; other site 868595006893 G5 box; other site 868595006894 Nucleoside recognition; Region: Gate; cl00486 868595006895 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 868595006896 FeoA domain; Region: FeoA; cl00838 868595006897 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 868595006898 active site 868595006899 Divergent PAP2 family; Region: DUF212; cl00855 868595006900 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595006901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595006902 putative substrate translocation pore; other site 868595006903 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 868595006904 NodB motif; other site 868595006905 putative active site [active] 868595006906 putative catalytic site [active] 868595006907 putative Zn binding site [ion binding]; other site 868595006908 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 868595006909 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 868595006910 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 868595006911 protein binding site [polypeptide binding]; other site 868595006912 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595006913 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595006914 Transposase; Region: DEDD_Tnp_IS110; pfam01548 868595006915 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 868595006916 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 868595006917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595006918 Zn2+ binding site [ion binding]; other site 868595006919 Mg2+ binding site [ion binding]; other site 868595006920 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 868595006921 NodB motif; other site 868595006922 active site 868595006923 catalytic site [active] 868595006924 metal binding site [ion binding]; metal-binding site 868595006925 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595006926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006927 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595006928 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 868595006929 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595006930 4Fe-4S binding domain; Region: Fer4; cl02805 868595006931 4Fe-4S binding domain; Region: Fer4; cl02805 868595006932 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 868595006933 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 868595006934 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 868595006935 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595006936 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 868595006937 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 868595006938 ATP-sulfurylase; Region: ATPS; cd00517 868595006939 active site 868595006940 HXXH motif; other site 868595006941 flexible loop; other site 868595006942 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 868595006943 Cysteine-rich domain; Region: CCG; pfam02754 868595006944 Cysteine-rich domain; Region: CCG; pfam02754 868595006945 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 868595006946 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 868595006947 Flagellin N-methylase; Region: FliB; cl00497 868595006948 Protein of unknown function (DUF964); Region: DUF964; cl01483 868595006949 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595006950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595006951 active site 868595006952 phosphorylation site [posttranslational modification] 868595006953 intermolecular recognition site; other site 868595006954 dimerization interface [polypeptide binding]; other site 868595006955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595006956 DNA binding site [nucleotide binding] 868595006957 EamA-like transporter family; Region: EamA; cl01037 868595006958 PilZ domain; Region: PilZ; cl01260 868595006959 VanW like protein; Region: VanW; pfam04294 868595006960 G5 domain; Region: G5; pfam07501 868595006961 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 868595006962 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 868595006963 putative FMN binding site [chemical binding]; other site 868595006964 DEAD-like helicases superfamily; Region: DEXDc; smart00487 868595006965 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595006966 ATP binding site [chemical binding]; other site 868595006967 putative Mg++ binding site [ion binding]; other site 868595006968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595006969 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 868595006970 nucleotide binding region [chemical binding]; other site 868595006971 ATP-binding site [chemical binding]; other site 868595006972 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 868595006973 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 868595006974 S-layer homology domain; Region: SLH; pfam00395 868595006975 S-layer homology domain; Region: SLH; pfam00395 868595006976 Predicted permease; Region: DUF318; pfam03773 868595006977 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 868595006978 catalytic residues [active] 868595006979 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 868595006980 4Fe-4S binding domain; Region: Fer4_5; pfam12801 868595006981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595006982 S-adenosylmethionine binding site [chemical binding]; other site 868595006983 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 868595006984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595006985 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 868595006986 Short C-terminal domain; Region: SHOCT; cl01373 868595006987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595006988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595006989 active site 868595006990 phosphorylation site [posttranslational modification] 868595006991 intermolecular recognition site; other site 868595006992 dimerization interface [polypeptide binding]; other site 868595006993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595006994 DNA binding site [nucleotide binding] 868595006995 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 868595006996 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 868595006997 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595006998 metal binding site [ion binding]; metal-binding site 868595006999 active site 868595007000 I-site; other site 868595007001 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 868595007002 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 868595007003 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 868595007004 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 868595007005 S-layer homology domain; Region: SLH; pfam00395 868595007006 S-layer homology domain; Region: SLH; pfam00395 868595007007 S-layer homology domain; Region: SLH; pfam00395 868595007008 Iron permease FTR1 family; Region: FTR1; cl00475 868595007009 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 868595007010 trimer interface [polypeptide binding]; other site 868595007011 active site 868595007012 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 868595007013 4Fe-4S binding domain; Region: Fer4_5; pfam12801 868595007014 4Fe-4S binding domain; Region: Fer4; cl02805 868595007015 Arginase family; Region: Arginase; cl00306 868595007016 spermidine synthase; Provisional; Region: PRK00811 868595007017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595007018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595007019 S-adenosylmethionine binding site [chemical binding]; other site 868595007020 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 868595007021 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 868595007022 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 868595007023 Metal-binding active site; metal-binding site 868595007024 AP (apurinic/apyrimidinic) site pocket; other site 868595007025 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 868595007026 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 868595007027 peptide binding site [polypeptide binding]; other site 868595007028 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 868595007029 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 868595007030 trimer interface [polypeptide binding]; other site 868595007031 putative metal binding site [ion binding]; other site 868595007032 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 868595007033 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 868595007034 homotetramer interface [polypeptide binding]; other site 868595007035 FMN binding site [chemical binding]; other site 868595007036 homodimer contacts [polypeptide binding]; other site 868595007037 putative active site [active] 868595007038 putative substrate binding site [chemical binding]; other site 868595007039 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 868595007040 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 868595007041 G1 box; other site 868595007042 putative GEF interaction site [polypeptide binding]; other site 868595007043 GTP/Mg2+ binding site [chemical binding]; other site 868595007044 Switch I region; other site 868595007045 G2 box; other site 868595007046 G3 box; other site 868595007047 Switch II region; other site 868595007048 G4 box; other site 868595007049 G5 box; other site 868595007050 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 868595007051 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 868595007052 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 868595007053 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 868595007054 Membrane protein of unknown function; Region: DUF360; cl00850 868595007055 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 868595007056 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 868595007057 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 868595007058 transposase; Provisional; Region: PRK06526 868595007059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595007060 Walker A motif; other site 868595007061 ATP binding site [chemical binding]; other site 868595007062 Walker B motif; other site 868595007063 Helix-turn-helix domains; Region: HTH; cl00088 868595007064 Winged helix-turn helix; Region: HTH_29; pfam13551 868595007065 Integrase core domain; Region: rve; cl01316 868595007066 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595007067 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 868595007068 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 868595007069 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 868595007070 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595007071 4Fe-4S binding domain; Region: Fer4; cl02805 868595007072 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595007073 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 868595007074 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 868595007075 Polysulphide reductase, NrfD; Region: NrfD; cl01295 868595007076 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 868595007077 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 868595007078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595007079 putative substrate translocation pore; other site 868595007080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595007081 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 868595007082 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 868595007083 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 868595007084 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 868595007085 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 868595007086 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595007087 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 868595007088 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 868595007089 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 868595007090 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 868595007091 metal binding site [ion binding]; metal-binding site 868595007092 RDD family; Region: RDD; cl00746 868595007093 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 868595007094 Cysteine-rich domain; Region: CCG; pfam02754 868595007095 Cysteine-rich domain; Region: CCG; pfam02754 868595007096 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 868595007097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595007098 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 868595007099 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 868595007100 Protein of unknown function (DUF327); Region: DUF327; cl00753 868595007101 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595007102 MULE transposase domain; Region: MULE; pfam10551 868595007103 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 868595007104 Integral membrane protein TerC family; Region: TerC; cl10468 868595007105 FOG: CBS domain [General function prediction only]; Region: COG0517 868595007106 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 868595007107 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 868595007108 Spore germination protein; Region: Spore_permease; cl15802 868595007109 amino acid transporter; Region: 2A0306; TIGR00909 868595007110 Spore germination protein; Region: Spore_permease; cl15802 868595007111 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 868595007112 putative homodimer interface [polypeptide binding]; other site 868595007113 putative active site pocket [active] 868595007114 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 868595007115 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 868595007116 EamA-like transporter family; Region: EamA; cl01037 868595007117 EamA-like transporter family; Region: EamA; cl01037 868595007118 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 868595007119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595007120 ATP binding site [chemical binding]; other site 868595007121 putative Mg++ binding site [ion binding]; other site 868595007122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595007123 nucleotide binding region [chemical binding]; other site 868595007124 Hef nuclease; Provisional; Region: PRK13766 868595007125 ATP-binding site [chemical binding]; other site 868595007126 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 868595007127 RQC domain; Region: RQC; cl09632 868595007128 HRDC domain; Region: HRDC; cl02578 868595007129 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595007130 dimerization interface [polypeptide binding]; other site 868595007131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595007132 dimer interface [polypeptide binding]; other site 868595007133 putative CheW interface [polypeptide binding]; other site 868595007134 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 868595007135 dinuclear metal binding motif [ion binding]; other site 868595007136 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 868595007137 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 868595007138 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 868595007139 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 868595007140 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 868595007141 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 868595007142 active site 868595007143 multimer interface [polypeptide binding]; other site 868595007144 threonine synthase; Validated; Region: PRK08197 868595007145 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 868595007146 homodimer interface [polypeptide binding]; other site 868595007147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595007148 catalytic residue [active] 868595007149 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 868595007150 homotrimer interaction site [polypeptide binding]; other site 868595007151 putative active site [active] 868595007152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 868595007153 YheO-like PAS domain; Region: PAS_6; pfam08348 868595007154 Helix-turn-helix domains; Region: HTH; cl00088 868595007155 TIGR02677 family protein; Region: TIGR02677 868595007156 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 868595007157 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 868595007158 TIGR02680 family protein; Region: TIGR02680 868595007159 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 868595007160 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 868595007161 TIGR02679 family protein; Region: TIGR02679 868595007162 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 868595007163 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 868595007164 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 868595007165 Uncharacterized conserved protein [Function unknown]; Region: COG3535 868595007166 Protein of unknown function (DUF917); Region: DUF917; pfam06032 868595007167 Sodium:solute symporter family; Region: SSF; cl00456 868595007168 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 868595007169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595007170 Walker A motif; other site 868595007171 ATP binding site [chemical binding]; other site 868595007172 Walker B motif; other site 868595007173 arginine finger; other site 868595007174 Helix-turn-helix domains; Region: HTH; cl00088 868595007175 Protein of unknown function (DUF917); Region: DUF917; pfam06032 868595007176 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 868595007177 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 868595007178 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 868595007179 SmpB-tmRNA interface; other site 868595007180 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 868595007181 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 868595007182 CoenzymeA binding site [chemical binding]; other site 868595007183 subunit interaction site [polypeptide binding]; other site 868595007184 PHB binding site; other site 868595007185 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 868595007186 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 868595007187 enolase; Provisional; Region: eno; PRK00077 868595007188 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 868595007189 dimer interface [polypeptide binding]; other site 868595007190 metal binding site [ion binding]; metal-binding site 868595007191 substrate binding pocket [chemical binding]; other site 868595007192 Sulfatase; Region: Sulfatase; cl10460 868595007193 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 868595007194 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 868595007195 substrate binding site [chemical binding]; other site 868595007196 dimer interface [polypeptide binding]; other site 868595007197 catalytic triad [active] 868595007198 Phosphoglycerate kinase; Region: PGK; pfam00162 868595007199 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 868595007200 substrate binding site [chemical binding]; other site 868595007201 hinge regions; other site 868595007202 ADP binding site [chemical binding]; other site 868595007203 catalytic site [active] 868595007204 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 868595007205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595007206 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 868595007207 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 868595007208 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 868595007209 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 868595007210 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 868595007211 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 868595007212 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 868595007213 trimer interface [polypeptide binding]; other site 868595007214 CoA binding site [chemical binding]; other site 868595007215 active site 868595007216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 868595007217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 868595007218 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 868595007219 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 868595007220 putative active site [active] 868595007221 putative metal binding site [ion binding]; other site 868595007222 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 868595007223 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 868595007224 phosphate binding site [ion binding]; other site 868595007225 putative substrate binding pocket [chemical binding]; other site 868595007226 dimer interface [polypeptide binding]; other site 868595007227 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 868595007228 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 868595007229 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 868595007230 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 868595007231 regulatory protein interface [polypeptide binding]; other site 868595007232 active site 868595007233 regulatory phosphorylation site [posttranslational modification]; other site 868595007234 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 868595007235 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 868595007236 motif II; other site 868595007237 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 868595007238 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 868595007239 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 868595007240 GIY-YIG motif/motif A; other site 868595007241 active site 868595007242 catalytic site [active] 868595007243 putative DNA binding site [nucleotide binding]; other site 868595007244 metal binding site [ion binding]; metal-binding site 868595007245 UvrB/uvrC motif; Region: UVR; pfam02151 868595007246 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 868595007247 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 868595007248 Helix-turn-helix domains; Region: HTH; cl00088 868595007249 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 868595007250 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 868595007251 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 868595007252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595007253 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 868595007254 Walker A/P-loop; other site 868595007255 ATP binding site [chemical binding]; other site 868595007256 Q-loop/lid; other site 868595007257 ABC transporter signature motif; other site 868595007258 Walker B; other site 868595007259 D-loop; other site 868595007260 H-loop/switch region; other site 868595007261 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 868595007262 ABC-2 type transporter; Region: ABC2_membrane; cl11417 868595007263 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 868595007264 ABC-2 type transporter; Region: ABC2_membrane; cl11417 868595007265 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 868595007266 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 868595007267 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 868595007268 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 868595007269 excinuclease ABC subunit B; Provisional; Region: PRK05298 868595007270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595007271 ATP binding site [chemical binding]; other site 868595007272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595007273 nucleotide binding region [chemical binding]; other site 868595007274 ATP-binding site [chemical binding]; other site 868595007275 Ultra-violet resistance protein B; Region: UvrB; pfam12344 868595007276 UvrB/uvrC motif; Region: UVR; pfam02151 868595007277 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 868595007278 Rubredoxin; Region: Rubredoxin; pfam00301 868595007279 iron binding site [ion binding]; other site 868595007280 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 868595007281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 868595007282 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 868595007283 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 868595007284 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 868595007285 Fe-S cluster binding site [ion binding]; other site 868595007286 active site 868595007287 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 868595007288 Predicted RNA-binding protein; Region: RNA_bind_2; cl00662 868595007289 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 868595007290 protein binding site [polypeptide binding]; other site 868595007291 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 868595007292 C-terminal peptidase (prc); Region: prc; TIGR00225 868595007293 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 868595007294 protein binding site [polypeptide binding]; other site 868595007295 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 868595007296 Catalytic dyad [active] 868595007297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 868595007298 Peptidase family M23; Region: Peptidase_M23; pfam01551 868595007299 FtsX-like permease family; Region: FtsX; cl15850 868595007300 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 868595007301 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595007302 Walker A/P-loop; other site 868595007303 ATP binding site [chemical binding]; other site 868595007304 Q-loop/lid; other site 868595007305 ABC transporter signature motif; other site 868595007306 Walker B; other site 868595007307 D-loop; other site 868595007308 H-loop/switch region; other site 868595007309 OpgC protein; Region: OpgC_C; cl00792 868595007310 Acyltransferase family; Region: Acyl_transf_3; pfam01757 868595007311 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 868595007312 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 868595007313 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 868595007314 PYR/PP interface [polypeptide binding]; other site 868595007315 dimer interface [polypeptide binding]; other site 868595007316 TPP binding site [chemical binding]; other site 868595007317 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 868595007318 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 868595007319 TPP-binding site [chemical binding]; other site 868595007320 dimer interface [polypeptide binding]; other site 868595007321 Uncharacterized conserved protein [Function unknown]; Region: COG1284 868595007322 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 868595007323 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 868595007324 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 868595007325 peptide chain release factor 2; Validated; Region: prfB; PRK00578 868595007326 RF-1 domain; Region: RF-1; cl02875 868595007327 RF-1 domain; Region: RF-1; cl02875 868595007328 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 868595007329 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595007330 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 868595007331 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 868595007332 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 868595007333 tetramer interface [polypeptide binding]; other site 868595007334 catalytic Zn binding site [ion binding]; other site 868595007335 NADP binding site [chemical binding]; other site 868595007336 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 868595007337 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595007338 catalytic loop [active] 868595007339 iron binding site [ion binding]; other site 868595007340 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 868595007341 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 868595007342 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 868595007343 active site 868595007344 NAD binding site [chemical binding]; other site 868595007345 metal binding site [ion binding]; metal-binding site 868595007346 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 868595007347 30S subunit binding site; other site 868595007348 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 868595007349 DNA-binding site [nucleotide binding]; DNA binding site 868595007350 RNA-binding motif; other site 868595007351 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 868595007352 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595007353 active site 868595007354 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 868595007355 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 868595007356 GAF domain; Region: GAF; cl15785 868595007357 GAF domain; Region: GAF_2; pfam13185 868595007358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595007359 metal binding site [ion binding]; metal-binding site 868595007360 active site 868595007361 I-site; other site 868595007362 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 868595007363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595007364 S-adenosylmethionine synthetase; Validated; Region: PRK05250 868595007365 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 868595007366 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 868595007367 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 868595007368 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 868595007369 integral membrane protein MviN; Region: mviN; TIGR01695 868595007370 MatE; Region: MatE; cl10513 868595007371 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 868595007372 active site 868595007373 catalytic triad [active] 868595007374 S-layer homology domain; Region: SLH; pfam00395 868595007375 S-layer homology domain; Region: SLH; pfam00395 868595007376 S-layer homology domain; Region: SLH; pfam00395 868595007377 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 868595007378 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 868595007379 active site 868595007380 substrate binding site [chemical binding]; other site 868595007381 metal binding site [ion binding]; metal-binding site 868595007382 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 868595007383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595007384 NAD(P) binding site [chemical binding]; other site 868595007385 active site 868595007386 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 868595007387 active site 868595007388 tetramer interface; other site 868595007389 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 868595007390 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 868595007391 Mg++ binding site [ion binding]; other site 868595007392 putative catalytic motif [active] 868595007393 substrate binding site [chemical binding]; other site 868595007394 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 868595007395 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 868595007396 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 868595007397 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595007398 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 868595007399 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 868595007400 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 868595007401 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 868595007402 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 868595007403 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 868595007404 Uncharacterized conserved protein [Function unknown]; Region: COG5464 868595007405 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 868595007406 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 868595007407 putative active site [active] 868595007408 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595007409 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595007410 DNA binding residues [nucleotide binding] 868595007411 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595007412 catalytic residues [active] 868595007413 catalytic nucleophile [active] 868595007414 Nitrogen regulatory protein P-II; Region: P-II; cl00412 868595007415 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 868595007416 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 868595007417 catalytic triad [active] 868595007418 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595007419 Transposase domain (DUF772); Region: DUF772; cl15789 868595007420 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595007421 Transposase domain (DUF772); Region: DUF772; cl15789 868595007422 Transposase domain (DUF772); Region: DUF772; cl15789 868595007423 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 868595007424 active site 868595007425 NTP binding site [chemical binding]; other site 868595007426 metal binding triad [ion binding]; metal-binding site 868595007427 antibiotic binding site [chemical binding]; other site 868595007428 Protein of unknown function DUF86; Region: DUF86; cl01031 868595007429 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 868595007430 active site 868595007431 catalytic triad [active] 868595007432 oxyanion hole [active] 868595007433 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595007434 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595007435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595007436 active site 868595007437 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 868595007438 putative homodimer interface [polypeptide binding]; other site 868595007439 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595007440 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 868595007441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595007442 TraB family; Region: TraB; cl12050 868595007443 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 868595007444 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 868595007445 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 868595007446 Walker A/P-loop; other site 868595007447 ATP binding site [chemical binding]; other site 868595007448 Q-loop/lid; other site 868595007449 ABC transporter signature motif; other site 868595007450 Walker B; other site 868595007451 D-loop; other site 868595007452 H-loop/switch region; other site 868595007453 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 868595007454 putative carbohydrate binding site [chemical binding]; other site 868595007455 ABC-2 type transporter; Region: ABC2_membrane; cl11417 868595007456 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 868595007457 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 868595007458 NAD binding site [chemical binding]; other site 868595007459 substrate binding site [chemical binding]; other site 868595007460 homodimer interface [polypeptide binding]; other site 868595007461 active site 868595007462 Cupin domain; Region: Cupin_2; cl09118 868595007463 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 868595007464 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 868595007465 substrate binding site; other site 868595007466 tetramer interface; other site 868595007467 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 868595007468 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 868595007469 NADP binding site [chemical binding]; other site 868595007470 active site 868595007471 putative substrate binding site [chemical binding]; other site 868595007472 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595007473 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595007474 active site 868595007475 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 868595007476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595007477 Bacterial sugar transferase; Region: Bac_transf; cl00939 868595007478 O-Antigen ligase; Region: Wzy_C; cl04850 868595007479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595007480 binding surface 868595007481 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 868595007482 TPR motif; other site 868595007483 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 868595007484 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595007485 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595007486 PQQ-like domain; Region: PQQ_2; pfam13360 868595007487 rod shape-determining protein Mbl; Provisional; Region: PRK13928 868595007488 Cell division protein FtsA; Region: FtsA; cl11496 868595007489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 868595007490 Peptidase family M23; Region: Peptidase_M23; pfam01551 868595007491 stage II sporulation protein D; Region: spore_II_D; TIGR02870 868595007492 Stage II sporulation protein; Region: SpoIID; pfam08486 868595007493 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 868595007494 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 868595007495 hinge; other site 868595007496 active site 868595007497 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 868595007498 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 868595007499 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 868595007500 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 868595007501 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 868595007502 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 868595007503 alpha subunit interaction interface [polypeptide binding]; other site 868595007504 Walker A motif; other site 868595007505 ATP binding site [chemical binding]; other site 868595007506 Walker B motif; other site 868595007507 inhibitor binding site; inhibition site 868595007508 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 868595007509 ATP synthase; Region: ATP-synt; cl00365 868595007510 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 868595007511 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 868595007512 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 868595007513 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 868595007514 beta subunit interaction interface [polypeptide binding]; other site 868595007515 Walker A motif; other site 868595007516 ATP binding site [chemical binding]; other site 868595007517 Walker B motif; other site 868595007518 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 868595007519 Plant ATP synthase F0; Region: YMF19; cl07975 868595007520 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 868595007521 Plant ATP synthase F0; Region: YMF19; cl07975 868595007522 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 868595007523 ATP synthase subunit C; Region: ATP-synt_C; cl00466 868595007524 ATP synthase A chain; Region: ATP-synt_A; cl00413 868595007525 ATP synthase I chain; Region: ATP_synt_I; cl09170 868595007526 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 868595007527 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 868595007528 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 868595007529 active site 868595007530 homodimer interface [polypeptide binding]; other site 868595007531 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 868595007532 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 868595007533 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 868595007534 catalytic motif [active] 868595007535 Zn binding site [ion binding]; other site 868595007536 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 868595007537 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 868595007538 dimer interface [polypeptide binding]; other site 868595007539 glycine-pyridoxal phosphate binding site [chemical binding]; other site 868595007540 active site 868595007541 folate binding site [chemical binding]; other site 868595007542 Low molecular weight phosphatase family; Region: LMWPc; cd00115 868595007543 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 868595007544 active site 868595007545 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 868595007546 Domain of unknown function DUF; Region: DUF204; pfam02659 868595007547 Domain of unknown function DUF; Region: DUF204; pfam02659 868595007548 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 868595007549 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 868595007550 High-affinity nickel-transport protein; Region: NicO; cl00964 868595007551 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 868595007552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595007553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595007554 S-adenosylmethionine binding site [chemical binding]; other site 868595007555 peptide chain release factor 1; Validated; Region: prfA; PRK00591 868595007556 RF-1 domain; Region: RF-1; cl02875 868595007557 RF-1 domain; Region: RF-1; cl02875 868595007558 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 868595007559 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 868595007560 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 868595007561 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595007562 putative peptidoglycan binding site; other site 868595007563 Peptidase family M23; Region: Peptidase_M23; pfam01551 868595007564 transcription termination factor Rho; Provisional; Region: rho; PRK09376 868595007565 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 868595007566 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 868595007567 RNA binding site [nucleotide binding]; other site 868595007568 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 868595007569 multimer interface [polypeptide binding]; other site 868595007570 Walker A motif; other site 868595007571 ATP binding site [chemical binding]; other site 868595007572 Walker B motif; other site 868595007573 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 868595007574 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 868595007575 active site 868595007576 intersubunit interactions; other site 868595007577 catalytic residue [active] 868595007578 hypothetical protein; Provisional; Region: PRK08185 868595007579 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 868595007580 intersubunit interface [polypeptide binding]; other site 868595007581 active site 868595007582 zinc binding site [ion binding]; other site 868595007583 Na+ binding site [ion binding]; other site 868595007584 Response regulator receiver domain; Region: Response_reg; pfam00072 868595007585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595007586 active site 868595007587 phosphorylation site [posttranslational modification] 868595007588 intermolecular recognition site; other site 868595007589 dimerization interface [polypeptide binding]; other site 868595007590 Yip1 domain; Region: Yip1; cl12048 868595007591 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 868595007592 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 868595007593 tandem repeat interface [polypeptide binding]; other site 868595007594 oligomer interface [polypeptide binding]; other site 868595007595 active site residues [active] 868595007596 CTP synthetase; Validated; Region: pyrG; PRK05380 868595007597 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 868595007598 Catalytic site [active] 868595007599 active site 868595007600 UTP binding site [chemical binding]; other site 868595007601 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 868595007602 active site 868595007603 putative oxyanion hole; other site 868595007604 catalytic triad [active] 868595007605 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 868595007606 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 868595007607 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 868595007608 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 868595007609 active site 868595007610 HIGH motif; other site 868595007611 KMSK motif region; other site 868595007612 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 868595007613 tRNA binding surface [nucleotide binding]; other site 868595007614 anticodon binding site; other site 868595007615 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 868595007616 Adenosine deaminase z-alpha domain; Region: z-alpha; cl02659 868595007617 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 868595007618 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595007619 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 868595007620 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595007621 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 868595007622 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 868595007623 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 868595007624 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 868595007625 dimer interface [polypeptide binding]; other site 868595007626 PYR/PP interface [polypeptide binding]; other site 868595007627 TPP binding site [chemical binding]; other site 868595007628 substrate binding site [chemical binding]; other site 868595007629 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 868595007630 TPP-binding site; other site 868595007631 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 868595007632 AMP-binding enzyme; Region: AMP-binding; cl15778 868595007633 AMP-binding enzyme; Region: AMP-binding; cl15778 868595007634 Sodium:solute symporter family; Region: SSF; cl00456 868595007635 hypothetical protein; Validated; Region: PRK07682 868595007636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595007637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595007638 homodimer interface [polypeptide binding]; other site 868595007639 catalytic residue [active] 868595007640 Helix-turn-helix domains; Region: HTH; cl00088 868595007641 germination protein YpeB; Region: spore_YpeB; TIGR02889 868595007642 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 868595007643 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 868595007644 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595007645 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 868595007646 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595007647 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 868595007648 catalytic triad [active] 868595007649 DsrC like protein; Region: DsrC; cl01101 868595007650 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595007651 Cysteine-rich domain; Region: CCG; pfam02754 868595007652 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 868595007653 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595007654 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595007655 Protein of unknown function (DUF964); Region: DUF964; cl01483 868595007656 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 868595007657 DctM-like transporters; Region: DctM; pfam06808 868595007658 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 868595007659 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 868595007660 NMT1-like family; Region: NMT1_2; cl15260 868595007661 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 868595007662 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 868595007663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 868595007664 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 868595007665 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 868595007666 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 868595007667 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 868595007668 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 868595007669 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 868595007670 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 868595007671 putative NADH binding site [chemical binding]; other site 868595007672 putative active site [active] 868595007673 nudix motif; other site 868595007674 putative metal binding site [ion binding]; other site 868595007675 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 868595007676 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595007677 Zn2+ binding site [ion binding]; other site 868595007678 Mg2+ binding site [ion binding]; other site 868595007679 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 868595007680 anti sigma factor interaction site; other site 868595007681 regulatory phosphorylation site [posttranslational modification]; other site 868595007682 Protein of unknown function (DUF342); Region: DUF342; pfam03961 868595007683 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 868595007684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595007685 ATP binding site [chemical binding]; other site 868595007686 Mg2+ binding site [ion binding]; other site 868595007687 G-X-G motif; other site 868595007688 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 868595007689 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 868595007690 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 868595007691 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 868595007692 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 868595007693 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 868595007694 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 868595007695 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 868595007696 dimerization domain swap beta strand [polypeptide binding]; other site 868595007697 regulatory protein interface [polypeptide binding]; other site 868595007698 active site 868595007699 regulatory phosphorylation site [posttranslational modification]; other site 868595007700 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 868595007701 active site 868595007702 phosphorylation site [posttranslational modification] 868595007703 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 868595007704 P-loop; other site 868595007705 active site 868595007706 phosphorylation site [posttranslational modification] 868595007707 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 868595007708 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 868595007709 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 868595007710 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 868595007711 putative substrate binding site [chemical binding]; other site 868595007712 putative ATP binding site [chemical binding]; other site 868595007713 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 868595007714 Helix-turn-helix domains; Region: HTH; cl00088 868595007715 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 868595007716 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 868595007717 Membrane transport protein; Region: Mem_trans; cl09117 868595007718 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 868595007719 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 868595007720 catalytic triad [active] 868595007721 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 868595007722 FMN binding site [chemical binding]; other site 868595007723 dimer interface [polypeptide binding]; other site 868595007724 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 868595007725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595007726 FeS/SAM binding site; other site 868595007727 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595007728 dimerization interface [polypeptide binding]; other site 868595007729 putative DNA binding site [nucleotide binding]; other site 868595007730 putative Zn2+ binding site [ion binding]; other site 868595007731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595007732 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 868595007733 active site 868595007734 motif I; other site 868595007735 motif II; other site 868595007736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595007737 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 868595007738 nudix motif; other site 868595007739 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 868595007740 putative deacylase active site [active] 868595007741 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 868595007742 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 868595007743 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 868595007744 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 868595007745 hinge; other site 868595007746 active site 868595007747 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 868595007748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595007749 binding surface 868595007750 TPR motif; other site 868595007751 TPR repeat; Region: TPR_11; pfam13414 868595007752 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 868595007753 putative peptidoglycan binding site; other site 868595007754 G5 domain; Region: G5; pfam07501 868595007755 Peptidase family M23; Region: Peptidase_M23; pfam01551 868595007756 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 868595007757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595007758 FeS/SAM binding site; other site 868595007759 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 868595007760 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 868595007761 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 868595007762 GDP-binding site [chemical binding]; other site 868595007763 ACT binding site; other site 868595007764 IMP binding site; other site 868595007765 replicative DNA helicase; Region: DnaB; TIGR00665 868595007766 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 868595007767 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 868595007768 Walker A motif; other site 868595007769 ATP binding site [chemical binding]; other site 868595007770 Walker B motif; other site 868595007771 DNA binding loops [nucleotide binding] 868595007772 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 868595007773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595007774 Walker A motif; other site 868595007775 ATP binding site [chemical binding]; other site 868595007776 Walker B motif; other site 868595007777 arginine finger; other site 868595007778 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 868595007779 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 868595007780 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 868595007781 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 868595007782 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 868595007783 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 868595007784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595007785 putative substrate translocation pore; other site 868595007786 Transcriptional regulators [Transcription]; Region: MarR; COG1846 868595007787 Helix-turn-helix domains; Region: HTH; cl00088 868595007788 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 868595007789 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 868595007790 dimer interface [polypeptide binding]; other site 868595007791 ssDNA binding site [nucleotide binding]; other site 868595007792 tetramer (dimer of dimers) interface [polypeptide binding]; other site 868595007793 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 868595007794 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 868595007795 Mechanosensitive ion channel; Region: MS_channel; pfam00924 868595007796 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 868595007797 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 868595007798 oligomer interface [polypeptide binding]; other site 868595007799 putative active site [active] 868595007800 metal binding site [ion binding]; metal-binding site 868595007801 Colicin V production protein; Region: Colicin_V; cl00567 868595007802 Colicin V production protein; Region: Colicin_V; cl00567 868595007803 Uncharacterized membrane protein [Function unknown]; Region: COG3949 868595007804 Sodium:solute symporter family; Region: SSF; cl00456 868595007805 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 868595007806 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595007807 active site 868595007808 Protein of unknown function DUF111; Region: DUF111; cl03398 868595007809 Protein of unknown function (DUF554); Region: DUF554; cl00784 868595007810 ParB-like partition proteins; Region: parB_part; TIGR00180 868595007811 ParB-like nuclease domain; Region: ParBc; cl02129 868595007812 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 868595007813 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 868595007814 P-loop; other site 868595007815 Magnesium ion binding site [ion binding]; other site 868595007816 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 868595007817 Magnesium ion binding site [ion binding]; other site 868595007818 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 868595007819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 868595007820 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 868595007821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595007822 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 868595007823 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 868595007824 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 868595007825 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 868595007826 trmE is a tRNA modification GTPase; Region: trmE; cd04164 868595007827 G1 box; other site 868595007828 GTP/Mg2+ binding site [chemical binding]; other site 868595007829 Switch I region; other site 868595007830 G2 box; other site 868595007831 Switch II region; other site 868595007832 G3 box; other site 868595007833 G4 box; other site 868595007834 G5 box; other site 868595007835 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 868595007836 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595007837 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 868595007838 Ribonuclease P; Region: Ribonuclease_P; cl00457