-- dump date 20140619_073433 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1211025000001 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1211025000002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025000003 DNA-binding site [nucleotide binding]; DNA binding site 1211025000004 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1211025000005 putative transporter; Provisional; Region: PRK10504 1211025000006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000007 putative substrate translocation pore; other site 1211025000008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000009 transcriptional repressor RbsR; Provisional; Region: PRK10423 1211025000010 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025000011 DNA binding site [nucleotide binding] 1211025000012 domain linker motif; other site 1211025000013 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1211025000014 dimerization interface [polypeptide binding]; other site 1211025000015 ligand binding site [chemical binding]; other site 1211025000016 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1211025000017 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1211025000018 substrate binding site [chemical binding]; other site 1211025000019 dimer interface [polypeptide binding]; other site 1211025000020 ATP binding site [chemical binding]; other site 1211025000021 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1211025000022 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1211025000023 ligand binding site [chemical binding]; other site 1211025000024 dimerization interface [polypeptide binding]; other site 1211025000025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025000026 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025000027 TM-ABC transporter signature motif; other site 1211025000028 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1211025000029 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1211025000030 Walker A/P-loop; other site 1211025000031 ATP binding site [chemical binding]; other site 1211025000032 Q-loop/lid; other site 1211025000033 ABC transporter signature motif; other site 1211025000034 Walker B; other site 1211025000035 D-loop; other site 1211025000036 H-loop/switch region; other site 1211025000037 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1211025000038 D-ribose pyranase; Provisional; Region: PRK11797 1211025000039 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1211025000040 potassium uptake protein; Region: kup; TIGR00794 1211025000041 regulatory ATPase RavA; Provisional; Region: PRK13531 1211025000042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025000043 Walker A motif; other site 1211025000044 ATP binding site [chemical binding]; other site 1211025000045 Walker B motif; other site 1211025000046 arginine finger; other site 1211025000047 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1211025000048 hypothetical protein; Provisional; Region: yieM; PRK10997 1211025000049 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1211025000050 metal ion-dependent adhesion site (MIDAS); other site 1211025000051 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1211025000052 dimer interface [polypeptide binding]; other site 1211025000053 active site 1211025000054 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1211025000055 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1211025000056 putative DNA binding site [nucleotide binding]; other site 1211025000057 putative Zn2+ binding site [ion binding]; other site 1211025000058 AsnC family; Region: AsnC_trans_reg; pfam01037 1211025000059 FMN-binding protein MioC; Provisional; Region: PRK09004 1211025000060 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1211025000061 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1211025000062 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1211025000063 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1211025000064 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1211025000065 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1211025000066 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1211025000067 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1211025000068 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1211025000069 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1211025000070 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1211025000071 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1211025000072 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1211025000073 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1211025000074 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1211025000075 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1211025000076 beta subunit interaction interface [polypeptide binding]; other site 1211025000077 Walker A motif; other site 1211025000078 ATP binding site [chemical binding]; other site 1211025000079 Walker B motif; other site 1211025000080 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1211025000081 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1211025000082 core domain interface [polypeptide binding]; other site 1211025000083 delta subunit interface [polypeptide binding]; other site 1211025000084 epsilon subunit interface [polypeptide binding]; other site 1211025000085 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1211025000086 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1211025000087 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1211025000088 alpha subunit interaction interface [polypeptide binding]; other site 1211025000089 Walker A motif; other site 1211025000090 ATP binding site [chemical binding]; other site 1211025000091 Walker B motif; other site 1211025000092 inhibitor binding site; inhibition site 1211025000093 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1211025000094 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1211025000095 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1211025000096 gamma subunit interface [polypeptide binding]; other site 1211025000097 epsilon subunit interface [polypeptide binding]; other site 1211025000098 LBP interface [polypeptide binding]; other site 1211025000099 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1211025000100 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1211025000101 Substrate binding site; other site 1211025000102 Mg++ binding site; other site 1211025000103 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1211025000104 active site 1211025000105 substrate binding site [chemical binding]; other site 1211025000106 CoA binding site [chemical binding]; other site 1211025000107 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1211025000108 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1211025000109 glutaminase active site [active] 1211025000110 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1211025000111 dimer interface [polypeptide binding]; other site 1211025000112 active site 1211025000113 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1211025000114 dimer interface [polypeptide binding]; other site 1211025000115 active site 1211025000116 Fimbrial protein; Region: Fimbrial; cl01416 1211025000117 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 1211025000118 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025000119 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025000120 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1211025000121 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025000122 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025000123 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025000124 Fimbrial protein; Region: Fimbrial; cl01416 1211025000125 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025000126 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1211025000127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025000128 dimer interface [polypeptide binding]; other site 1211025000129 conserved gate region; other site 1211025000130 putative PBP binding loops; other site 1211025000131 ABC-ATPase subunit interface; other site 1211025000132 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1211025000133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025000134 dimer interface [polypeptide binding]; other site 1211025000135 conserved gate region; other site 1211025000136 putative PBP binding loops; other site 1211025000137 ABC-ATPase subunit interface; other site 1211025000138 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1211025000139 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1211025000140 Walker A/P-loop; other site 1211025000141 ATP binding site [chemical binding]; other site 1211025000142 Q-loop/lid; other site 1211025000143 ABC transporter signature motif; other site 1211025000144 Walker B; other site 1211025000145 D-loop; other site 1211025000146 H-loop/switch region; other site 1211025000147 transcriptional regulator PhoU; Provisional; Region: PRK11115 1211025000148 PhoU domain; Region: PhoU; pfam01895 1211025000149 PhoU domain; Region: PhoU; pfam01895 1211025000150 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1211025000151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025000152 active site 1211025000153 motif I; other site 1211025000154 motif II; other site 1211025000155 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1211025000156 Predicted flavoprotein [General function prediction only]; Region: COG0431 1211025000157 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1211025000158 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1211025000159 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1211025000160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025000161 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1211025000162 substrate binding pocket [chemical binding]; other site 1211025000163 dimerization interface [polypeptide binding]; other site 1211025000164 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1211025000165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000166 putative substrate translocation pore; other site 1211025000167 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1211025000168 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1211025000169 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1211025000170 G1 box; other site 1211025000171 GTP/Mg2+ binding site [chemical binding]; other site 1211025000172 Switch I region; other site 1211025000173 G2 box; other site 1211025000174 Switch II region; other site 1211025000175 G3 box; other site 1211025000176 G4 box; other site 1211025000177 G5 box; other site 1211025000178 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1211025000179 membrane protein insertase; Provisional; Region: PRK01318 1211025000180 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1211025000181 hypothetical protein; Validated; Region: PRK00041 1211025000182 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1211025000183 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1211025000184 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1211025000185 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1211025000186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025000187 Walker A motif; other site 1211025000188 ATP binding site [chemical binding]; other site 1211025000189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1211025000190 Walker B motif; other site 1211025000191 arginine finger; other site 1211025000192 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1211025000193 DnaA box-binding interface [nucleotide binding]; other site 1211025000194 DNA polymerase III subunit beta; Validated; Region: PRK05643 1211025000195 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1211025000196 putative DNA binding surface [nucleotide binding]; other site 1211025000197 dimer interface [polypeptide binding]; other site 1211025000198 beta-clamp/clamp loader binding surface; other site 1211025000199 beta-clamp/translesion DNA polymerase binding surface; other site 1211025000200 recF protein; Region: recf; TIGR00611 1211025000201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025000202 Walker A/P-loop; other site 1211025000203 ATP binding site [chemical binding]; other site 1211025000204 Q-loop/lid; other site 1211025000205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025000206 ABC transporter signature motif; other site 1211025000207 Walker B; other site 1211025000208 D-loop; other site 1211025000209 H-loop/switch region; other site 1211025000210 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1211025000211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025000212 Mg2+ binding site [ion binding]; other site 1211025000213 G-X-G motif; other site 1211025000214 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1211025000215 anchoring element; other site 1211025000216 dimer interface [polypeptide binding]; other site 1211025000217 ATP binding site [chemical binding]; other site 1211025000218 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1211025000219 active site 1211025000220 putative metal-binding site [ion binding]; other site 1211025000221 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1211025000222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025000223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025000224 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1211025000225 putative effector binding pocket; other site 1211025000226 putative dimerization interface [polypeptide binding]; other site 1211025000227 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1211025000228 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1211025000229 putative NAD(P) binding site [chemical binding]; other site 1211025000230 sugar phosphate phosphatase; Provisional; Region: PRK10513 1211025000231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025000232 active site 1211025000233 motif I; other site 1211025000234 motif II; other site 1211025000235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025000236 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1211025000237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025000238 DNA-binding site [nucleotide binding]; DNA binding site 1211025000239 FCD domain; Region: FCD; pfam07729 1211025000240 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1211025000241 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1211025000242 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1211025000243 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1211025000244 active site 1211025000245 intersubunit interface [polypeptide binding]; other site 1211025000246 catalytic residue [active] 1211025000247 galactonate dehydratase; Provisional; Region: PRK14017 1211025000248 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1211025000249 putative active site pocket [active] 1211025000250 putative metal binding site [ion binding]; other site 1211025000251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000252 D-galactonate transporter; Region: 2A0114; TIGR00893 1211025000253 putative substrate translocation pore; other site 1211025000254 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1211025000255 hypothetical protein; Provisional; Region: PRK11616 1211025000256 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1211025000257 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1211025000258 putative dimer interface [polypeptide binding]; other site 1211025000259 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1211025000260 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1211025000261 putative dimer interface [polypeptide binding]; other site 1211025000262 putative transporter; Validated; Region: PRK03818 1211025000263 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1211025000264 TrkA-C domain; Region: TrkA_C; pfam02080 1211025000265 TrkA-C domain; Region: TrkA_C; pfam02080 1211025000266 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1211025000267 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1211025000268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025000269 DNA-binding site [nucleotide binding]; DNA binding site 1211025000270 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1211025000271 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1211025000272 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1211025000273 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025000274 active site turn [active] 1211025000275 phosphorylation site [posttranslational modification] 1211025000276 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1211025000277 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1211025000278 NAD binding site [chemical binding]; other site 1211025000279 sugar binding site [chemical binding]; other site 1211025000280 divalent metal binding site [ion binding]; other site 1211025000281 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1211025000282 dimer interface [polypeptide binding]; other site 1211025000283 Predicted membrane protein [Function unknown]; Region: COG2149 1211025000284 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1211025000285 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1211025000286 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1211025000287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1211025000288 catalytic residue [active] 1211025000289 permease DsdX; Provisional; Region: PRK09921 1211025000290 gluconate transporter; Region: gntP; TIGR00791 1211025000291 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1211025000292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025000293 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1211025000294 dimerization interface [polypeptide binding]; other site 1211025000295 substrate binding pocket [chemical binding]; other site 1211025000296 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1211025000297 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1211025000298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000299 putative substrate translocation pore; other site 1211025000300 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1211025000301 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1211025000302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025000303 Coenzyme A binding pocket [chemical binding]; other site 1211025000304 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1211025000305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025000306 non-specific DNA binding site [nucleotide binding]; other site 1211025000307 salt bridge; other site 1211025000308 sequence-specific DNA binding site [nucleotide binding]; other site 1211025000309 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1211025000310 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1211025000311 PYR/PP interface [polypeptide binding]; other site 1211025000312 dimer interface [polypeptide binding]; other site 1211025000313 TPP binding site [chemical binding]; other site 1211025000314 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1211025000315 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1211025000316 TPP-binding site [chemical binding]; other site 1211025000317 dimer interface [polypeptide binding]; other site 1211025000318 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1211025000319 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1211025000320 putative valine binding site [chemical binding]; other site 1211025000321 dimer interface [polypeptide binding]; other site 1211025000322 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1211025000323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025000324 active site 1211025000325 phosphorylation site [posttranslational modification] 1211025000326 intermolecular recognition site; other site 1211025000327 dimerization interface [polypeptide binding]; other site 1211025000328 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025000329 DNA binding residues [nucleotide binding] 1211025000330 dimerization interface [polypeptide binding]; other site 1211025000331 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1211025000332 MASE1; Region: MASE1; pfam05231 1211025000333 Histidine kinase; Region: HisKA_3; pfam07730 1211025000334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025000335 ATP binding site [chemical binding]; other site 1211025000336 Mg2+ binding site [ion binding]; other site 1211025000337 G-X-G motif; other site 1211025000338 regulatory protein UhpC; Provisional; Region: PRK11663 1211025000339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000340 putative substrate translocation pore; other site 1211025000341 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1211025000342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000343 putative substrate translocation pore; other site 1211025000344 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1211025000345 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1211025000346 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1211025000347 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1211025000348 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1211025000349 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1211025000350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000351 putative substrate translocation pore; other site 1211025000352 EamA-like transporter family; Region: EamA; pfam00892 1211025000353 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1211025000354 EamA-like transporter family; Region: EamA; pfam00892 1211025000355 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1211025000356 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1211025000357 methionine cluster; other site 1211025000358 active site 1211025000359 phosphorylation site [posttranslational modification] 1211025000360 metal binding site [ion binding]; metal-binding site 1211025000361 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1211025000362 beta-galactosidase; Region: BGL; TIGR03356 1211025000363 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1211025000364 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1211025000365 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1211025000366 active site 1211025000367 P-loop; other site 1211025000368 phosphorylation site [posttranslational modification] 1211025000369 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025000370 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025000371 DNA binding site [nucleotide binding] 1211025000372 domain linker motif; other site 1211025000373 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1211025000374 ligand binding site [chemical binding]; other site 1211025000375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025000376 Coenzyme A binding pocket [chemical binding]; other site 1211025000377 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1211025000378 lipoprotein, YaeC family; Region: TIGR00363 1211025000379 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1211025000380 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1211025000381 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1211025000382 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1211025000383 conserved cys residue [active] 1211025000384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025000385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025000386 Predicted ATPase [General function prediction only]; Region: COG4637 1211025000387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025000388 Walker A/P-loop; other site 1211025000389 ATP binding site [chemical binding]; other site 1211025000390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025000391 ABC transporter signature motif; other site 1211025000392 Walker B; other site 1211025000393 D-loop; other site 1211025000394 H-loop/switch region; other site 1211025000395 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1211025000396 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1211025000397 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1211025000398 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1211025000399 active site 1211025000400 homotetramer interface [polypeptide binding]; other site 1211025000401 transcriptional regulator MirA; Provisional; Region: PRK15043 1211025000402 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1211025000403 DNA binding residues [nucleotide binding] 1211025000404 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1211025000405 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1211025000406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1211025000407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025000408 Coenzyme A binding pocket [chemical binding]; other site 1211025000409 Protein of unknown function (DUF796); Region: DUF796; cl01226 1211025000410 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1211025000411 HicB family; Region: HicB; pfam05534 1211025000412 Uncharacterized conserved protein [Function unknown]; Region: COG4938 1211025000413 Protein of unknown function DUF262; Region: DUF262; pfam03235 1211025000414 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1211025000415 putative transporter; Provisional; Region: PRK11462 1211025000416 putative alpha-glucosidase; Provisional; Region: PRK10658 1211025000417 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1211025000418 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1211025000419 active site 1211025000420 homotrimer interface [polypeptide binding]; other site 1211025000421 catalytic site [active] 1211025000422 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1211025000423 AsmA family; Region: AsmA; pfam05170 1211025000424 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1211025000425 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1211025000426 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1211025000427 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1211025000428 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1211025000429 generic binding surface II; other site 1211025000430 ssDNA binding site; other site 1211025000431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025000432 ATP binding site [chemical binding]; other site 1211025000433 putative Mg++ binding site [ion binding]; other site 1211025000434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025000435 nucleotide binding region [chemical binding]; other site 1211025000436 ATP-binding site [chemical binding]; other site 1211025000437 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1211025000438 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1211025000439 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1211025000440 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1211025000441 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1211025000442 Zn2+ binding site [ion binding]; other site 1211025000443 Mg2+ binding site [ion binding]; other site 1211025000444 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1211025000445 synthetase active site [active] 1211025000446 NTP binding site [chemical binding]; other site 1211025000447 metal binding site [ion binding]; metal-binding site 1211025000448 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1211025000449 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1211025000450 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1211025000451 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1211025000452 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1211025000453 catalytic site [active] 1211025000454 G-X2-G-X-G-K; other site 1211025000455 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1211025000456 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1211025000457 nucleotide binding pocket [chemical binding]; other site 1211025000458 K-X-D-G motif; other site 1211025000459 catalytic site [active] 1211025000460 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1211025000461 Predicted membrane protein [Function unknown]; Region: COG2860 1211025000462 UPF0126 domain; Region: UPF0126; pfam03458 1211025000463 UPF0126 domain; Region: UPF0126; pfam03458 1211025000464 hypothetical protein; Provisional; Region: PRK11820 1211025000465 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1211025000466 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1211025000467 ribonuclease PH; Reviewed; Region: rph; PRK00173 1211025000468 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1211025000469 hexamer interface [polypeptide binding]; other site 1211025000470 active site 1211025000471 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1211025000472 active site 1211025000473 division inhibitor protein; Provisional; Region: slmA; PRK09480 1211025000474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025000475 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1211025000476 trimer interface [polypeptide binding]; other site 1211025000477 active site 1211025000478 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1211025000479 Flavoprotein; Region: Flavoprotein; pfam02441 1211025000480 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1211025000481 hypothetical protein; Reviewed; Region: PRK00024 1211025000482 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1211025000483 MPN+ (JAMM) motif; other site 1211025000484 Zinc-binding site [ion binding]; other site 1211025000485 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1211025000486 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1211025000487 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1211025000488 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1211025000489 DNA binding site [nucleotide binding] 1211025000490 catalytic residue [active] 1211025000491 H2TH interface [polypeptide binding]; other site 1211025000492 putative catalytic residues [active] 1211025000493 turnover-facilitating residue; other site 1211025000494 intercalation triad [nucleotide binding]; other site 1211025000495 8OG recognition residue [nucleotide binding]; other site 1211025000496 putative reading head residues; other site 1211025000497 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1211025000498 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1211025000499 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1211025000500 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1211025000501 active site 1211025000502 (T/H)XGH motif; other site 1211025000503 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1211025000504 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1211025000505 putative metal binding site; other site 1211025000506 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1211025000507 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1211025000508 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1211025000509 putative glycosyl transferase; Provisional; Region: PRK10073 1211025000510 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1211025000511 active site 1211025000512 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1211025000513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1211025000514 putative ADP-binding pocket [chemical binding]; other site 1211025000515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1211025000516 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1211025000517 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1211025000518 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1211025000519 putative active site [active] 1211025000520 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1211025000521 putative active site [active] 1211025000522 putative catalytic site [active] 1211025000523 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1211025000524 O-Antigen ligase; Region: Wzy_C; pfam04932 1211025000525 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1211025000526 active site 1211025000527 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1211025000528 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1211025000529 putative active site [active] 1211025000530 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1211025000531 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1211025000532 putative active site [active] 1211025000533 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1211025000534 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1211025000535 putative active site [active] 1211025000536 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1211025000537 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1211025000538 NADP binding site [chemical binding]; other site 1211025000539 homopentamer interface [polypeptide binding]; other site 1211025000540 substrate binding site [chemical binding]; other site 1211025000541 active site 1211025000542 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1211025000543 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1211025000544 substrate-cofactor binding pocket; other site 1211025000545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025000546 catalytic residue [active] 1211025000547 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1211025000548 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1211025000549 NAD(P) binding site [chemical binding]; other site 1211025000550 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1211025000551 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1211025000552 putative ADP-binding pocket [chemical binding]; other site 1211025000553 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1211025000554 NodB motif; other site 1211025000555 putative active site [active] 1211025000556 putative catalytic site [active] 1211025000557 Zn binding site [ion binding]; other site 1211025000558 AmiB activator; Provisional; Region: PRK11637 1211025000559 Peptidase family M23; Region: Peptidase_M23; pfam01551 1211025000560 phosphoglyceromutase; Provisional; Region: PRK05434 1211025000561 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1211025000562 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1211025000563 active site residue [active] 1211025000564 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1211025000565 GSH binding site [chemical binding]; other site 1211025000566 catalytic residues [active] 1211025000567 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1211025000568 SecA binding site; other site 1211025000569 Preprotein binding site; other site 1211025000570 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1211025000571 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1211025000572 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1211025000573 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1211025000574 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1211025000575 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1211025000576 trimer interface [polypeptide binding]; other site 1211025000577 active site 1211025000578 substrate binding site [chemical binding]; other site 1211025000579 CoA binding site [chemical binding]; other site 1211025000580 putative rRNA methylase; Provisional; Region: PRK10358 1211025000581 benzoate transport; Region: 2A0115; TIGR00895 1211025000582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000583 putative substrate translocation pore; other site 1211025000584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000585 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1211025000586 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1211025000587 active site 1211025000588 substrate binding site [chemical binding]; other site 1211025000589 FMN binding site [chemical binding]; other site 1211025000590 putative catalytic residues [active] 1211025000591 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1211025000592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025000593 DNA-binding site [nucleotide binding]; DNA binding site 1211025000594 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1211025000595 L-lactate permease; Provisional; Region: PRK10420 1211025000596 glycolate transporter; Provisional; Region: PRK09695 1211025000597 hypothetical protein; Provisional; Region: PRK11020 1211025000598 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1211025000599 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1211025000600 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1211025000601 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1211025000602 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1211025000603 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1211025000604 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1211025000605 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1211025000606 active site 1211025000607 P-loop; other site 1211025000608 phosphorylation site [posttranslational modification] 1211025000609 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1211025000610 active site 1211025000611 phosphorylation site [posttranslational modification] 1211025000612 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1211025000613 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1211025000614 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025000615 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025000616 putative glutathione S-transferase; Provisional; Region: PRK10357 1211025000617 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1211025000618 putative C-terminal domain interface [polypeptide binding]; other site 1211025000619 putative GSH binding site (G-site) [chemical binding]; other site 1211025000620 putative dimer interface [polypeptide binding]; other site 1211025000621 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1211025000622 dimer interface [polypeptide binding]; other site 1211025000623 N-terminal domain interface [polypeptide binding]; other site 1211025000624 putative substrate binding pocket (H-site) [chemical binding]; other site 1211025000625 selenocysteine synthase; Provisional; Region: PRK04311 1211025000626 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1211025000627 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1211025000628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1211025000629 catalytic residue [active] 1211025000630 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1211025000631 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1211025000632 G1 box; other site 1211025000633 putative GEF interaction site [polypeptide binding]; other site 1211025000634 GTP/Mg2+ binding site [chemical binding]; other site 1211025000635 Switch I region; other site 1211025000636 G2 box; other site 1211025000637 G3 box; other site 1211025000638 Switch II region; other site 1211025000639 G4 box; other site 1211025000640 G5 box; other site 1211025000641 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1211025000642 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1211025000643 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1211025000644 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1211025000645 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1211025000646 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1211025000647 NAD(P) binding site [chemical binding]; other site 1211025000648 catalytic residues [active] 1211025000649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025000650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025000651 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025000652 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1211025000653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1211025000654 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1211025000655 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1211025000656 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1211025000657 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1211025000658 Helix-turn-helix domain; Region: HTH_18; pfam12833 1211025000659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025000660 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1211025000661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025000662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025000663 homodimer interface [polypeptide binding]; other site 1211025000664 catalytic residue [active] 1211025000665 alpha-amylase; Reviewed; Region: malS; PRK09505 1211025000666 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1211025000667 active site 1211025000668 catalytic site [active] 1211025000669 hypothetical protein; Provisional; Region: PRK10356 1211025000670 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1211025000671 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1211025000672 putative dimerization interface [polypeptide binding]; other site 1211025000673 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025000674 putative ligand binding site [chemical binding]; other site 1211025000675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025000676 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1211025000677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025000678 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025000679 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025000680 TM-ABC transporter signature motif; other site 1211025000681 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1211025000682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025000683 Walker A/P-loop; other site 1211025000684 ATP binding site [chemical binding]; other site 1211025000685 Q-loop/lid; other site 1211025000686 ABC transporter signature motif; other site 1211025000687 Walker B; other site 1211025000688 D-loop; other site 1211025000689 H-loop/switch region; other site 1211025000690 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1211025000691 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1211025000692 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1211025000693 putative ligand binding site [chemical binding]; other site 1211025000694 potential frameshift: common BLAST hit: gi|365968471|ref|YP_004950032.1| Xylose isomerase 1211025000695 xylulokinase; Provisional; Region: PRK15027 1211025000696 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1211025000697 N- and C-terminal domain interface [polypeptide binding]; other site 1211025000698 active site 1211025000699 MgATP binding site [chemical binding]; other site 1211025000700 catalytic site [active] 1211025000701 metal binding site [ion binding]; metal-binding site 1211025000702 xylulose binding site [chemical binding]; other site 1211025000703 homodimer interface [polypeptide binding]; other site 1211025000704 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1211025000705 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1211025000706 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1211025000707 YsaB-like lipoprotein; Region: YsaB; pfam13983 1211025000708 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1211025000709 dimer interface [polypeptide binding]; other site 1211025000710 motif 1; other site 1211025000711 active site 1211025000712 motif 2; other site 1211025000713 motif 3; other site 1211025000714 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1211025000715 DALR anticodon binding domain; Region: DALR_1; pfam05746 1211025000716 anticodon binding site; other site 1211025000717 tRNA binding surface [nucleotide binding]; other site 1211025000718 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1211025000719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025000720 Walker A/P-loop; other site 1211025000721 ATP binding site [chemical binding]; other site 1211025000722 Q-loop/lid; other site 1211025000723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025000724 ABC transporter signature motif; other site 1211025000725 Walker B; other site 1211025000726 D-loop; other site 1211025000727 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025000728 Predicted transcriptional regulator [Transcription]; Region: COG2944 1211025000729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025000730 salt bridge; other site 1211025000731 non-specific DNA binding site [nucleotide binding]; other site 1211025000732 sequence-specific DNA binding site [nucleotide binding]; other site 1211025000733 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1211025000734 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1211025000735 DNA-binding site [nucleotide binding]; DNA binding site 1211025000736 RNA-binding motif; other site 1211025000737 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1211025000738 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1211025000739 dimerization interface [polypeptide binding]; other site 1211025000740 ligand binding site [chemical binding]; other site 1211025000741 NADP binding site [chemical binding]; other site 1211025000742 catalytic site [active] 1211025000743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000744 D-galactonate transporter; Region: 2A0114; TIGR00893 1211025000745 putative substrate translocation pore; other site 1211025000746 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1211025000747 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1211025000748 substrate binding site [chemical binding]; other site 1211025000749 ATP binding site [chemical binding]; other site 1211025000750 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1211025000751 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025000752 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025000753 DNA binding site [nucleotide binding] 1211025000754 domain linker motif; other site 1211025000755 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1211025000756 putative dimerization interface [polypeptide binding]; other site 1211025000757 putative ligand binding site [chemical binding]; other site 1211025000758 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1211025000759 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1211025000760 ligand binding site [chemical binding]; other site 1211025000761 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1211025000762 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1211025000763 molybdopterin cofactor binding site [chemical binding]; other site 1211025000764 substrate binding site [chemical binding]; other site 1211025000765 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1211025000766 molybdopterin cofactor binding site; other site 1211025000767 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1211025000768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025000769 Coenzyme A binding pocket [chemical binding]; other site 1211025000770 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1211025000771 Autotransporter beta-domain; Region: Autotransporter; cl17461 1211025000772 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1211025000773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025000774 putative substrate translocation pore; other site 1211025000775 phosphoethanolamine transferase; Provisional; Region: PRK11560 1211025000776 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1211025000777 Sulfatase; Region: Sulfatase; pfam00884 1211025000778 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1211025000779 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1211025000780 peptide binding site [polypeptide binding]; other site 1211025000781 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1211025000782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025000783 dimer interface [polypeptide binding]; other site 1211025000784 conserved gate region; other site 1211025000785 putative PBP binding loops; other site 1211025000786 ABC-ATPase subunit interface; other site 1211025000787 dipeptide transporter; Provisional; Region: PRK10913 1211025000788 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1211025000789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025000790 dimer interface [polypeptide binding]; other site 1211025000791 conserved gate region; other site 1211025000792 putative PBP binding loops; other site 1211025000793 ABC-ATPase subunit interface; other site 1211025000794 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1211025000795 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025000796 Walker A/P-loop; other site 1211025000797 ATP binding site [chemical binding]; other site 1211025000798 Q-loop/lid; other site 1211025000799 ABC transporter signature motif; other site 1211025000800 Walker B; other site 1211025000801 D-loop; other site 1211025000802 H-loop/switch region; other site 1211025000803 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1211025000804 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1211025000805 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025000806 Walker A/P-loop; other site 1211025000807 ATP binding site [chemical binding]; other site 1211025000808 Q-loop/lid; other site 1211025000809 ABC transporter signature motif; other site 1211025000810 Walker B; other site 1211025000811 D-loop; other site 1211025000812 H-loop/switch region; other site 1211025000813 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1211025000814 pantothenate kinase; Provisional; Region: PRK05439 1211025000815 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1211025000816 ATP-binding site [chemical binding]; other site 1211025000817 CoA-binding site [chemical binding]; other site 1211025000818 Mg2+-binding site [ion binding]; other site 1211025000819 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1211025000820 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1211025000821 G1 box; other site 1211025000822 GEF interaction site [polypeptide binding]; other site 1211025000823 GTP/Mg2+ binding site [chemical binding]; other site 1211025000824 Switch I region; other site 1211025000825 G2 box; other site 1211025000826 G3 box; other site 1211025000827 Switch II region; other site 1211025000828 G4 box; other site 1211025000829 G5 box; other site 1211025000830 Uncharacterized protein conserved in archaea (DUF2193); Region: DUF2193; cl02034 1211025000831 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1211025000832 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1211025000833 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1211025000834 putative homodimer interface [polypeptide binding]; other site 1211025000835 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1211025000836 heterodimer interface [polypeptide binding]; other site 1211025000837 homodimer interface [polypeptide binding]; other site 1211025000838 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1211025000839 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1211025000840 23S rRNA interface [nucleotide binding]; other site 1211025000841 L7/L12 interface [polypeptide binding]; other site 1211025000842 putative thiostrepton binding site; other site 1211025000843 L25 interface [polypeptide binding]; other site 1211025000844 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1211025000845 mRNA/rRNA interface [nucleotide binding]; other site 1211025000846 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1211025000847 23S rRNA interface [nucleotide binding]; other site 1211025000848 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1211025000849 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1211025000850 core dimer interface [polypeptide binding]; other site 1211025000851 peripheral dimer interface [polypeptide binding]; other site 1211025000852 L10 interface [polypeptide binding]; other site 1211025000853 L11 interface [polypeptide binding]; other site 1211025000854 putative EF-Tu interaction site [polypeptide binding]; other site 1211025000855 putative EF-G interaction site [polypeptide binding]; other site 1211025000856 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1211025000857 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1211025000858 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1211025000859 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1211025000860 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1211025000861 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1211025000862 RPB3 interaction site [polypeptide binding]; other site 1211025000863 RPB1 interaction site [polypeptide binding]; other site 1211025000864 RPB11 interaction site [polypeptide binding]; other site 1211025000865 RPB10 interaction site [polypeptide binding]; other site 1211025000866 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1211025000867 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1211025000868 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1211025000869 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1211025000870 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1211025000871 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1211025000872 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1211025000873 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1211025000874 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1211025000875 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1211025000876 DNA binding site [nucleotide binding] 1211025000877 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1211025000878 methionine cluster; other site 1211025000879 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 1211025000880 active site 1211025000881 phosphorylation site [posttranslational modification] 1211025000882 metal binding site [ion binding]; metal-binding site 1211025000883 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1211025000884 active site 1211025000885 P-loop; other site 1211025000886 phosphorylation site [posttranslational modification] 1211025000887 Cache domain; Region: Cache_1; pfam02743 1211025000888 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025000889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025000890 metal binding site [ion binding]; metal-binding site 1211025000891 active site 1211025000892 I-site; other site 1211025000893 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1211025000894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025000895 FeS/SAM binding site; other site 1211025000896 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1211025000897 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1211025000898 ThiS interaction site; other site 1211025000899 putative active site [active] 1211025000900 tetramer interface [polypeptide binding]; other site 1211025000901 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1211025000902 thiS-thiF/thiG interaction site; other site 1211025000903 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1211025000904 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1211025000905 ATP binding site [chemical binding]; other site 1211025000906 substrate interface [chemical binding]; other site 1211025000907 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1211025000908 thiamine phosphate binding site [chemical binding]; other site 1211025000909 active site 1211025000910 pyrophosphate binding site [ion binding]; other site 1211025000911 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1211025000912 ThiC-associated domain; Region: ThiC-associated; pfam13667 1211025000913 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1211025000914 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1211025000915 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1211025000916 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1211025000917 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1211025000918 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1211025000919 putative NADH binding site [chemical binding]; other site 1211025000920 putative active site [active] 1211025000921 nudix motif; other site 1211025000922 putative metal binding site [ion binding]; other site 1211025000923 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1211025000924 substrate binding site [chemical binding]; other site 1211025000925 active site 1211025000926 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1211025000927 Active_site [active] 1211025000928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1211025000929 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1211025000930 IHF dimer interface [polypeptide binding]; other site 1211025000931 IHF - DNA interface [nucleotide binding]; other site 1211025000932 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1211025000933 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1211025000934 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1211025000935 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1211025000936 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1211025000937 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1211025000938 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1211025000939 purine monophosphate binding site [chemical binding]; other site 1211025000940 dimer interface [polypeptide binding]; other site 1211025000941 putative catalytic residues [active] 1211025000942 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1211025000943 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1211025000944 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1211025000945 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1211025000946 proposed active site lysine [active] 1211025000947 conserved cys residue [active] 1211025000948 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1211025000949 malate synthase A; Region: malate_syn_A; TIGR01344 1211025000950 active site 1211025000951 isocitrate lyase; Provisional; Region: PRK15063 1211025000952 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1211025000953 tetramer interface [polypeptide binding]; other site 1211025000954 active site 1211025000955 Mg2+/Mn2+ binding site [ion binding]; other site 1211025000956 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1211025000957 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1211025000958 transcriptional repressor IclR; Provisional; Region: PRK11569 1211025000959 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1211025000960 Bacterial transcriptional regulator; Region: IclR; pfam01614 1211025000961 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1211025000962 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1211025000963 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1211025000964 substrate binding pocket [chemical binding]; other site 1211025000965 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1211025000966 B12 binding site [chemical binding]; other site 1211025000967 cobalt ligand [ion binding]; other site 1211025000968 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1211025000969 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1211025000970 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1211025000971 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1211025000972 CcdB protein; Region: CcdB; cl03380 1211025000973 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1211025000974 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1211025000975 RNA binding surface [nucleotide binding]; other site 1211025000976 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1211025000977 probable active site [active] 1211025000978 hypothetical protein; Provisional; Region: PRK10515 1211025000979 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1211025000980 Sodium Bile acid symporter family; Region: SBF; pfam01758 1211025000981 aspartate kinase III; Validated; Region: PRK09084 1211025000982 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1211025000983 nucleotide binding site [chemical binding]; other site 1211025000984 substrate binding site [chemical binding]; other site 1211025000985 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1211025000986 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1211025000987 dimer interface [polypeptide binding]; other site 1211025000988 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1211025000989 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1211025000990 active site 1211025000991 dimer interface [polypeptide binding]; other site 1211025000992 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1211025000993 dimer interface [polypeptide binding]; other site 1211025000994 active site 1211025000995 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1211025000996 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1211025000997 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1211025000998 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1211025000999 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1211025001000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025001001 dimer interface [polypeptide binding]; other site 1211025001002 conserved gate region; other site 1211025001003 putative PBP binding loops; other site 1211025001004 ABC-ATPase subunit interface; other site 1211025001005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025001006 dimer interface [polypeptide binding]; other site 1211025001007 conserved gate region; other site 1211025001008 putative PBP binding loops; other site 1211025001009 ABC-ATPase subunit interface; other site 1211025001010 potential frameshift: common BLAST hit: gi|296100660|ref|YP_003610806.1| maltose ABC transporter periplasmic protein 1211025001011 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1211025001012 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1211025001013 Walker A/P-loop; other site 1211025001014 ATP binding site [chemical binding]; other site 1211025001015 Q-loop/lid; other site 1211025001016 ABC transporter signature motif; other site 1211025001017 Walker B; other site 1211025001018 D-loop; other site 1211025001019 H-loop/switch region; other site 1211025001020 TOBE domain; Region: TOBE_2; pfam08402 1211025001021 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1211025001022 trimer interface; other site 1211025001023 sugar binding site [chemical binding]; other site 1211025001024 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1211025001025 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1211025001026 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1211025001027 UbiA prenyltransferase family; Region: UbiA; pfam01040 1211025001028 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1211025001029 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1211025001030 metal-binding site [ion binding] 1211025001031 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1211025001032 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1211025001033 Predicted membrane protein [Function unknown]; Region: COG3714 1211025001034 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1211025001035 hypothetical protein; Provisional; Region: PRK10910 1211025001036 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1211025001037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025001038 S-adenosylmethionine binding site [chemical binding]; other site 1211025001039 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1211025001040 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1211025001041 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1211025001042 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1211025001043 P loop; other site 1211025001044 GTP binding site [chemical binding]; other site 1211025001045 cell division protein FtsE; Provisional; Region: PRK10908 1211025001046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025001047 Walker A/P-loop; other site 1211025001048 ATP binding site [chemical binding]; other site 1211025001049 Q-loop/lid; other site 1211025001050 ABC transporter signature motif; other site 1211025001051 Walker B; other site 1211025001052 D-loop; other site 1211025001053 H-loop/switch region; other site 1211025001054 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1211025001055 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1211025001056 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1211025001057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1211025001058 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1211025001059 DNA binding residues [nucleotide binding] 1211025001060 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1211025001061 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1211025001062 inhibitor-cofactor binding pocket; inhibition site 1211025001063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025001064 catalytic residue [active] 1211025001065 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1211025001066 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1211025001067 dimerization interface [polypeptide binding]; other site 1211025001068 ligand binding site [chemical binding]; other site 1211025001069 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1211025001070 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1211025001071 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1211025001072 dimerization interface [polypeptide binding]; other site 1211025001073 ligand binding site [chemical binding]; other site 1211025001074 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025001075 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1211025001076 TM-ABC transporter signature motif; other site 1211025001077 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1211025001078 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1211025001079 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1211025001080 TM-ABC transporter signature motif; other site 1211025001081 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1211025001082 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1211025001083 Walker A/P-loop; other site 1211025001084 ATP binding site [chemical binding]; other site 1211025001085 Q-loop/lid; other site 1211025001086 ABC transporter signature motif; other site 1211025001087 Walker B; other site 1211025001088 D-loop; other site 1211025001089 H-loop/switch region; other site 1211025001090 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1211025001091 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1211025001092 Walker A/P-loop; other site 1211025001093 ATP binding site [chemical binding]; other site 1211025001094 Q-loop/lid; other site 1211025001095 ABC transporter signature motif; other site 1211025001096 Walker B; other site 1211025001097 D-loop; other site 1211025001098 H-loop/switch region; other site 1211025001099 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1211025001100 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1211025001101 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1211025001102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025001103 putative PBP binding loops; other site 1211025001104 dimer interface [polypeptide binding]; other site 1211025001105 ABC-ATPase subunit interface; other site 1211025001106 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1211025001107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025001108 dimer interface [polypeptide binding]; other site 1211025001109 conserved gate region; other site 1211025001110 putative PBP binding loops; other site 1211025001111 ABC-ATPase subunit interface; other site 1211025001112 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1211025001113 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1211025001114 Walker A/P-loop; other site 1211025001115 ATP binding site [chemical binding]; other site 1211025001116 Q-loop/lid; other site 1211025001117 ABC transporter signature motif; other site 1211025001118 Walker B; other site 1211025001119 D-loop; other site 1211025001120 H-loop/switch region; other site 1211025001121 TOBE domain; Region: TOBE_2; pfam08402 1211025001122 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1211025001123 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1211025001124 putative active site [active] 1211025001125 catalytic site [active] 1211025001126 putative metal binding site [ion binding]; other site 1211025001127 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1211025001128 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1211025001129 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1211025001130 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1211025001131 Coenzyme A binding pocket [chemical binding]; other site 1211025001132 putative oxidoreductase; Provisional; Region: PRK10206 1211025001133 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025001134 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1211025001135 Pirin-related protein [General function prediction only]; Region: COG1741 1211025001136 Pirin; Region: Pirin; pfam02678 1211025001137 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1211025001138 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025001139 DNA binding site [nucleotide binding] 1211025001140 domain linker motif; other site 1211025001141 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1211025001142 putative ligand binding site [chemical binding]; other site 1211025001143 putative dimerization interface [polypeptide binding]; other site 1211025001144 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1211025001145 ATP-binding site [chemical binding]; other site 1211025001146 Gluconate-6-phosphate binding site [chemical binding]; other site 1211025001147 low affinity gluconate transporter; Provisional; Region: PRK10472 1211025001148 gluconate transporter; Region: gntP; TIGR00791 1211025001149 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1211025001150 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1211025001151 putative acyl-acceptor binding pocket; other site 1211025001152 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1211025001153 LexA repressor; Validated; Region: PRK00215 1211025001154 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1211025001155 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1211025001156 Catalytic site [active] 1211025001157 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1211025001158 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1211025001159 hypothetical protein; Provisional; Region: PRK10428 1211025001160 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1211025001161 metal binding site 2 [ion binding]; metal-binding site 1211025001162 putative DNA binding helix; other site 1211025001163 metal binding site 1 [ion binding]; metal-binding site 1211025001164 dimer interface [polypeptide binding]; other site 1211025001165 structural Zn2+ binding site [ion binding]; other site 1211025001166 Cupin domain; Region: Cupin_2; cl17218 1211025001167 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1211025001168 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1211025001169 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1211025001170 FMN binding site [chemical binding]; other site 1211025001171 active site 1211025001172 catalytic residues [active] 1211025001173 substrate binding site [chemical binding]; other site 1211025001174 phage shock protein G; Reviewed; Region: pspG; PRK09459 1211025001175 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1211025001176 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1211025001177 NADP binding site [chemical binding]; other site 1211025001178 dimer interface [polypeptide binding]; other site 1211025001179 replicative DNA helicase; Provisional; Region: PRK08006 1211025001180 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1211025001181 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1211025001182 Walker A motif; other site 1211025001183 ATP binding site [chemical binding]; other site 1211025001184 Walker B motif; other site 1211025001185 DNA binding loops [nucleotide binding] 1211025001186 alanine racemase; Reviewed; Region: alr; PRK00053 1211025001187 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1211025001188 active site 1211025001189 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1211025001190 substrate binding site [chemical binding]; other site 1211025001191 catalytic residues [active] 1211025001192 dimer interface [polypeptide binding]; other site 1211025001193 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1211025001194 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025001195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025001196 homodimer interface [polypeptide binding]; other site 1211025001197 catalytic residue [active] 1211025001198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025001199 active site 1211025001200 motif I; other site 1211025001201 motif II; other site 1211025001202 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1211025001203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1211025001204 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1211025001205 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1211025001206 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1211025001207 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1211025001208 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1211025001209 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1211025001210 dimer interface [polypeptide binding]; other site 1211025001211 ssDNA binding site [nucleotide binding]; other site 1211025001212 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1211025001213 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1211025001214 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1211025001215 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1211025001216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025001217 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1211025001218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025001219 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1211025001220 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1211025001221 DNA binding residues [nucleotide binding] 1211025001222 dimer interface [polypeptide binding]; other site 1211025001223 [2Fe-2S] cluster binding site [ion binding]; other site 1211025001224 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1211025001225 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1211025001226 putative C-terminal domain interface [polypeptide binding]; other site 1211025001227 putative GSH binding site (G-site) [chemical binding]; other site 1211025001228 putative dimer interface [polypeptide binding]; other site 1211025001229 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1211025001230 putative N-terminal domain interface [polypeptide binding]; other site 1211025001231 putative dimer interface [polypeptide binding]; other site 1211025001232 putative substrate binding pocket (H-site) [chemical binding]; other site 1211025001233 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1211025001234 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1211025001235 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1211025001236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025001237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025001238 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1211025001239 putative dimerization interface [polypeptide binding]; other site 1211025001240 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1211025001241 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1211025001242 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1211025001243 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1211025001244 Na binding site [ion binding]; other site 1211025001245 Predicted membrane protein [Function unknown]; Region: COG3162 1211025001246 acetyl-CoA synthetase; Provisional; Region: PRK00174 1211025001247 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1211025001248 active site 1211025001249 CoA binding site [chemical binding]; other site 1211025001250 acyl-activating enzyme (AAE) consensus motif; other site 1211025001251 AMP binding site [chemical binding]; other site 1211025001252 acetate binding site [chemical binding]; other site 1211025001253 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1211025001254 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1211025001255 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1211025001256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1211025001257 binding surface 1211025001258 TPR motif; other site 1211025001259 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025001260 molybdopterin cofactor binding site; other site 1211025001261 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1211025001262 molybdopterin cofactor binding site; other site 1211025001263 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025001264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1211025001265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025001266 active site 1211025001267 phosphorylation site [posttranslational modification] 1211025001268 intermolecular recognition site; other site 1211025001269 dimerization interface [polypeptide binding]; other site 1211025001270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025001271 DNA binding site [nucleotide binding] 1211025001272 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1211025001273 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1211025001274 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1211025001275 putative ligand binding site [chemical binding]; other site 1211025001276 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025001277 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025001278 TM-ABC transporter signature motif; other site 1211025001279 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1211025001280 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1211025001281 Walker A/P-loop; other site 1211025001282 ATP binding site [chemical binding]; other site 1211025001283 Q-loop/lid; other site 1211025001284 ABC transporter signature motif; other site 1211025001285 Walker B; other site 1211025001286 D-loop; other site 1211025001287 H-loop/switch region; other site 1211025001288 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1211025001289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1211025001290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025001291 dimerization interface [polypeptide binding]; other site 1211025001292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025001293 dimer interface [polypeptide binding]; other site 1211025001294 phosphorylation site [posttranslational modification] 1211025001295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025001296 ATP binding site [chemical binding]; other site 1211025001297 Mg2+ binding site [ion binding]; other site 1211025001298 G-X-G motif; other site 1211025001299 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1211025001300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025001301 active site 1211025001302 phosphorylation site [posttranslational modification] 1211025001303 intermolecular recognition site; other site 1211025001304 dimerization interface [polypeptide binding]; other site 1211025001305 putative hydrolase; Provisional; Region: PRK02113 1211025001306 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1211025001307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025001308 Coenzyme A binding pocket [chemical binding]; other site 1211025001309 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1211025001310 AAA domain; Region: AAA_18; pfam13238 1211025001311 active site 1211025001312 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1211025001313 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1211025001314 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1211025001315 active site 1211025001316 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1211025001317 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1211025001318 Walker A/P-loop; other site 1211025001319 ATP binding site [chemical binding]; other site 1211025001320 Q-loop/lid; other site 1211025001321 ABC transporter signature motif; other site 1211025001322 Walker B; other site 1211025001323 D-loop; other site 1211025001324 H-loop/switch region; other site 1211025001325 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1211025001326 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025001327 Walker A/P-loop; other site 1211025001328 ATP binding site [chemical binding]; other site 1211025001329 Q-loop/lid; other site 1211025001330 ABC transporter signature motif; other site 1211025001331 Walker B; other site 1211025001332 D-loop; other site 1211025001333 H-loop/switch region; other site 1211025001334 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1211025001335 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1211025001336 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1211025001337 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1211025001338 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1211025001339 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1211025001340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025001341 DNA-binding site [nucleotide binding]; DNA binding site 1211025001342 UTRA domain; Region: UTRA; pfam07702 1211025001343 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1211025001344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025001345 dimer interface [polypeptide binding]; other site 1211025001346 conserved gate region; other site 1211025001347 putative PBP binding loops; other site 1211025001348 ABC-ATPase subunit interface; other site 1211025001349 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1211025001350 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 1211025001351 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1211025001352 Walker A/P-loop; other site 1211025001353 ATP binding site [chemical binding]; other site 1211025001354 Q-loop/lid; other site 1211025001355 ABC transporter signature motif; other site 1211025001356 Walker B; other site 1211025001357 D-loop; other site 1211025001358 H-loop/switch region; other site 1211025001359 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1211025001360 dimer interface [polypeptide binding]; other site 1211025001361 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1211025001362 hypothetical protein; Provisional; Region: PRK10220 1211025001363 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1211025001364 PhnA protein; Region: PhnA; pfam03831 1211025001365 hypothetical protein; Provisional; Region: PRK09866 1211025001366 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1211025001367 G1 box; other site 1211025001368 GTP/Mg2+ binding site [chemical binding]; other site 1211025001369 G2 box; other site 1211025001370 Switch I region; other site 1211025001371 G3 box; other site 1211025001372 Switch II region; other site 1211025001373 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1211025001374 G2 box; other site 1211025001375 Switch I region; other site 1211025001376 G3 box; other site 1211025001377 Switch II region; other site 1211025001378 G4 box; other site 1211025001379 G5 box; other site 1211025001380 YjcZ-like protein; Region: YjcZ; pfam13990 1211025001381 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1211025001382 proline/glycine betaine transporter; Provisional; Region: PRK10642 1211025001383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025001384 putative substrate translocation pore; other site 1211025001385 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1211025001386 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1211025001387 putative transcriptional regulator; Provisional; Region: PRK11640 1211025001388 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1211025001389 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1211025001390 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1211025001391 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1211025001392 DsbD alpha interface [polypeptide binding]; other site 1211025001393 catalytic residues [active] 1211025001394 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1211025001395 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1211025001396 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1211025001397 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1211025001398 Aspartase; Region: Aspartase; cd01357 1211025001399 active sites [active] 1211025001400 tetramer interface [polypeptide binding]; other site 1211025001401 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1211025001402 putative transporter; Provisional; Region: PRK11021 1211025001403 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1211025001404 oligomerisation interface [polypeptide binding]; other site 1211025001405 mobile loop; other site 1211025001406 roof hairpin; other site 1211025001407 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1211025001408 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1211025001409 ring oligomerisation interface [polypeptide binding]; other site 1211025001410 ATP/Mg binding site [chemical binding]; other site 1211025001411 stacking interactions; other site 1211025001412 hinge regions; other site 1211025001413 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1211025001414 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1211025001415 active site 1211025001416 hypothetical protein; Provisional; Region: PRK10519 1211025001417 Nucleoside recognition; Region: Gate; pfam07670 1211025001418 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1211025001419 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1211025001420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025001421 FeS/SAM binding site; other site 1211025001422 elongation factor P; Validated; Region: PRK00529 1211025001423 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1211025001424 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1211025001425 RNA binding site [nucleotide binding]; other site 1211025001426 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1211025001427 RNA binding site [nucleotide binding]; other site 1211025001428 Predicted small secreted protein [Function unknown]; Region: COG5510 1211025001429 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1211025001430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1211025001431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025001432 DNA binding residues [nucleotide binding] 1211025001433 dimerization interface [polypeptide binding]; other site 1211025001434 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1211025001435 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1211025001436 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1211025001437 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1211025001438 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1211025001439 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1211025001440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025001441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025001442 dimerization interface [polypeptide binding]; other site 1211025001443 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1211025001444 Iron-sulfur protein interface; other site 1211025001445 proximal quinone binding site [chemical binding]; other site 1211025001446 C-subunit interface; other site 1211025001447 distal quinone binding site; other site 1211025001448 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1211025001449 D-subunit interface [polypeptide binding]; other site 1211025001450 Iron-sulfur protein interface; other site 1211025001451 proximal quinone binding site [chemical binding]; other site 1211025001452 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1211025001453 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1211025001454 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1211025001455 L-aspartate oxidase; Provisional; Region: PRK06175 1211025001456 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1211025001457 poxB regulator PoxA; Provisional; Region: PRK09350 1211025001458 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1211025001459 motif 1; other site 1211025001460 dimer interface [polypeptide binding]; other site 1211025001461 active site 1211025001462 motif 2; other site 1211025001463 motif 3; other site 1211025001464 inner membrane transporter YjeM; Provisional; Region: PRK15238 1211025001465 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1211025001466 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 1211025001467 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1211025001468 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1211025001469 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1211025001470 GTPase RsgA; Reviewed; Region: PRK12288 1211025001471 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1211025001472 RNA binding site [nucleotide binding]; other site 1211025001473 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1211025001474 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1211025001475 GTP/Mg2+ binding site [chemical binding]; other site 1211025001476 G4 box; other site 1211025001477 G5 box; other site 1211025001478 G1 box; other site 1211025001479 Switch I region; other site 1211025001480 G2 box; other site 1211025001481 G3 box; other site 1211025001482 Switch II region; other site 1211025001483 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1211025001484 catalytic site [active] 1211025001485 putative active site [active] 1211025001486 putative substrate binding site [chemical binding]; other site 1211025001487 dimer interface [polypeptide binding]; other site 1211025001488 epoxyqueuosine reductase; Region: TIGR00276 1211025001489 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1211025001490 putative carbohydrate kinase; Provisional; Region: PRK10565 1211025001491 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1211025001492 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1211025001493 putative substrate binding site [chemical binding]; other site 1211025001494 putative ATP binding site [chemical binding]; other site 1211025001495 ADP-binding protein; Provisional; Region: PRK10646 1211025001496 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1211025001497 AMIN domain; Region: AMIN; pfam11741 1211025001498 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1211025001499 active site 1211025001500 metal binding site [ion binding]; metal-binding site 1211025001501 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1211025001502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025001503 ATP binding site [chemical binding]; other site 1211025001504 Mg2+ binding site [ion binding]; other site 1211025001505 G-X-G motif; other site 1211025001506 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1211025001507 ATP binding site [chemical binding]; other site 1211025001508 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1211025001509 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1211025001510 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1211025001511 bacterial Hfq-like; Region: Hfq; cd01716 1211025001512 hexamer interface [polypeptide binding]; other site 1211025001513 Sm1 motif; other site 1211025001514 RNA binding site [nucleotide binding]; other site 1211025001515 Sm2 motif; other site 1211025001516 GTPase HflX; Provisional; Region: PRK11058 1211025001517 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1211025001518 HflX GTPase family; Region: HflX; cd01878 1211025001519 G1 box; other site 1211025001520 GTP/Mg2+ binding site [chemical binding]; other site 1211025001521 Switch I region; other site 1211025001522 G2 box; other site 1211025001523 G3 box; other site 1211025001524 Switch II region; other site 1211025001525 G4 box; other site 1211025001526 G5 box; other site 1211025001527 FtsH protease regulator HflK; Provisional; Region: PRK10930 1211025001528 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1211025001529 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1211025001530 FtsH protease regulator HflC; Provisional; Region: PRK11029 1211025001531 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1211025001532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1211025001533 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1211025001534 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1211025001535 GDP-binding site [chemical binding]; other site 1211025001536 ACT binding site; other site 1211025001537 IMP binding site; other site 1211025001538 Predicted transcriptional regulator [Transcription]; Region: COG1959 1211025001539 transcriptional repressor NsrR; Provisional; Region: PRK11014 1211025001540 exoribonuclease R; Provisional; Region: PRK11642 1211025001541 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1211025001542 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1211025001543 RNB domain; Region: RNB; pfam00773 1211025001544 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1211025001545 RNA binding site [nucleotide binding]; other site 1211025001546 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1211025001547 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1211025001548 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1211025001549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025001550 metabolite-proton symporter; Region: 2A0106; TIGR00883 1211025001551 putative substrate translocation pore; other site 1211025001552 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1211025001553 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1211025001554 FAD binding site [chemical binding]; other site 1211025001555 substrate binding site [chemical binding]; other site 1211025001556 catalytic residues [active] 1211025001557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025001558 dimerization interface [polypeptide binding]; other site 1211025001559 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1211025001560 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025001561 dimer interface [polypeptide binding]; other site 1211025001562 putative CheW interface [polypeptide binding]; other site 1211025001563 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1211025001564 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1211025001565 esterase; Provisional; Region: PRK10566 1211025001566 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1211025001567 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1211025001568 transcriptional repressor UlaR; Provisional; Region: PRK13509 1211025001569 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1211025001570 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1211025001571 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1211025001572 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1211025001573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1211025001574 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1211025001575 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1211025001576 active site 1211025001577 P-loop; other site 1211025001578 phosphorylation site [posttranslational modification] 1211025001579 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1211025001580 active site 1211025001581 phosphorylation site [posttranslational modification] 1211025001582 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1211025001583 active site 1211025001584 dimer interface [polypeptide binding]; other site 1211025001585 magnesium binding site [ion binding]; other site 1211025001586 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1211025001587 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1211025001588 AP (apurinic/apyrimidinic) site pocket; other site 1211025001589 DNA interaction; other site 1211025001590 Metal-binding active site; metal-binding site 1211025001591 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1211025001592 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1211025001593 intersubunit interface [polypeptide binding]; other site 1211025001594 active site 1211025001595 Zn2+ binding site [ion binding]; other site 1211025001596 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1211025001597 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1211025001598 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1211025001599 dimer interface [polypeptide binding]; other site 1211025001600 ssDNA binding site [nucleotide binding]; other site 1211025001601 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1211025001602 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1211025001603 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1211025001604 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1211025001605 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1211025001606 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1211025001607 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1211025001608 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1211025001609 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1211025001610 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1211025001611 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1211025001612 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1211025001613 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1211025001614 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1211025001615 Hemerythrin-like domain; Region: Hr-like; cd12108 1211025001616 Fe binding site [ion binding]; other site 1211025001617 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1211025001618 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1211025001619 dimer interface [polypeptide binding]; other site 1211025001620 ligand binding site [chemical binding]; other site 1211025001621 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025001622 dimerization interface [polypeptide binding]; other site 1211025001623 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025001624 dimer interface [polypeptide binding]; other site 1211025001625 putative CheW interface [polypeptide binding]; other site 1211025001626 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1211025001627 EamA-like transporter family; Region: EamA; pfam00892 1211025001628 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1211025001629 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1211025001630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025001631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025001632 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1211025001633 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1211025001634 NADP binding site [chemical binding]; other site 1211025001635 Predicted transcriptional regulators [Transcription]; Region: COG1733 1211025001636 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1211025001637 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1211025001638 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1211025001639 active site 1211025001640 metal binding site [ion binding]; metal-binding site 1211025001641 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1211025001642 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1211025001643 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1211025001644 active site 1211025001645 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 1211025001646 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1211025001647 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1211025001648 Domain of unknown function DUF21; Region: DUF21; pfam01595 1211025001649 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1211025001650 Transporter associated domain; Region: CorC_HlyC; smart01091 1211025001651 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1211025001652 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1211025001653 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025001654 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025001655 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1211025001656 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025001657 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025001658 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1211025001659 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025001660 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025001661 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1211025001662 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025001663 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025001664 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1211025001665 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025001666 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025001667 DNA binding site [nucleotide binding] 1211025001668 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1211025001669 ligand binding site [chemical binding]; other site 1211025001670 dimerization interface [polypeptide binding]; other site 1211025001671 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1211025001672 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1211025001673 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1211025001674 Surface antigen; Region: Bac_surface_Ag; pfam01103 1211025001675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1211025001676 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1211025001677 Family of unknown function (DUF490); Region: DUF490; pfam04357 1211025001678 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1211025001679 putative active site pocket [active] 1211025001680 dimerization interface [polypeptide binding]; other site 1211025001681 putative catalytic residue [active] 1211025001682 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1211025001683 dimer interface [polypeptide binding]; other site 1211025001684 substrate binding site [chemical binding]; other site 1211025001685 metal binding sites [ion binding]; metal-binding site 1211025001686 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1211025001687 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1211025001688 putative ligand binding site [chemical binding]; other site 1211025001689 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1211025001690 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1211025001691 Walker A/P-loop; other site 1211025001692 ATP binding site [chemical binding]; other site 1211025001693 Q-loop/lid; other site 1211025001694 ABC transporter signature motif; other site 1211025001695 Walker B; other site 1211025001696 D-loop; other site 1211025001697 H-loop/switch region; other site 1211025001698 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1211025001699 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025001700 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025001701 TM-ABC transporter signature motif; other site 1211025001702 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025001703 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025001704 TM-ABC transporter signature motif; other site 1211025001705 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1211025001706 dimer interface [polypeptide binding]; other site 1211025001707 ligand binding site [chemical binding]; other site 1211025001708 HAMP domain; Region: HAMP; pfam00672 1211025001709 dimerization interface [polypeptide binding]; other site 1211025001710 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1211025001711 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025001712 dimer interface [polypeptide binding]; other site 1211025001713 putative CheW interface [polypeptide binding]; other site 1211025001714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025001715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025001716 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1211025001717 AMP binding site [chemical binding]; other site 1211025001718 metal binding site [ion binding]; metal-binding site 1211025001719 active site 1211025001720 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1211025001721 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1211025001722 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1211025001723 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1211025001724 hypothetical protein; Provisional; Region: PRK05255 1211025001725 peptidase PmbA; Provisional; Region: PRK11040 1211025001726 cytochrome b562; Provisional; Region: PRK15058 1211025001727 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1211025001728 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 1211025001729 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1211025001730 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1211025001731 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1211025001732 dihydroorotase; Provisional; Region: PRK09237 1211025001733 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1211025001734 active site 1211025001735 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1211025001736 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1211025001737 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1211025001738 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1211025001739 HTH domain; Region: HTH_11; pfam08279 1211025001740 Mga helix-turn-helix domain; Region: Mga; pfam05043 1211025001741 PRD domain; Region: PRD; pfam00874 1211025001742 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1211025001743 active site 1211025001744 P-loop; other site 1211025001745 phosphorylation site [posttranslational modification] 1211025001746 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1211025001747 active site 1211025001748 phosphorylation site [posttranslational modification] 1211025001749 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1211025001750 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1211025001751 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 1211025001752 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1211025001753 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1211025001754 ATP cone domain; Region: ATP-cone; pfam03477 1211025001755 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1211025001756 effector binding site; other site 1211025001757 active site 1211025001758 Zn binding site [ion binding]; other site 1211025001759 glycine loop; other site 1211025001760 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1211025001761 active site 1211025001762 phosphorylation site [posttranslational modification] 1211025001763 alpha-mannosidase; Provisional; Region: PRK09819 1211025001764 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1211025001765 active site 1211025001766 metal binding site [ion binding]; metal-binding site 1211025001767 catalytic site [active] 1211025001768 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1211025001769 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1211025001770 active site 1211025001771 P-loop; other site 1211025001772 phosphorylation site [posttranslational modification] 1211025001773 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1211025001774 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1211025001775 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1211025001776 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1211025001777 putative active site [active] 1211025001778 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1211025001779 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1211025001780 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1211025001781 Ca binding site [ion binding]; other site 1211025001782 active site 1211025001783 catalytic site [active] 1211025001784 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1211025001785 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1211025001786 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025001787 active site turn [active] 1211025001788 phosphorylation site [posttranslational modification] 1211025001789 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1211025001790 trehalose repressor; Provisional; Region: treR; PRK09492 1211025001791 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025001792 DNA binding site [nucleotide binding] 1211025001793 domain linker motif; other site 1211025001794 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1211025001795 dimerization interface [polypeptide binding]; other site 1211025001796 ligand binding site [chemical binding]; other site 1211025001797 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1211025001798 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1211025001799 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1211025001800 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1211025001801 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1211025001802 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1211025001803 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1211025001804 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1211025001805 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1211025001806 active site 1211025001807 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1211025001808 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 1211025001809 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1211025001810 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1211025001811 homotrimer interaction site [polypeptide binding]; other site 1211025001812 putative active site [active] 1211025001813 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1211025001814 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1211025001815 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1211025001816 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1211025001817 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1211025001818 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1211025001819 Arginine repressor [Transcription]; Region: ArgR; COG1438 1211025001820 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1211025001821 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1211025001822 Predicted membrane protein [Function unknown]; Region: COG1288 1211025001823 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1211025001824 ornithine carbamoyltransferase; Validated; Region: PRK02102 1211025001825 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1211025001826 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1211025001827 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1211025001828 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1211025001829 putative substrate binding site [chemical binding]; other site 1211025001830 nucleotide binding site [chemical binding]; other site 1211025001831 nucleotide binding site [chemical binding]; other site 1211025001832 homodimer interface [polypeptide binding]; other site 1211025001833 arginine deiminase; Provisional; Region: PRK01388 1211025001834 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1211025001835 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1211025001836 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1211025001837 inhibitor site; inhibition site 1211025001838 active site 1211025001839 dimer interface [polypeptide binding]; other site 1211025001840 catalytic residue [active] 1211025001841 putative dehydratase; Provisional; Region: PRK08211 1211025001842 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 1211025001843 putative symporter YagG; Provisional; Region: PRK09669 1211025001844 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1211025001845 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1211025001846 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1211025001847 inhibitor binding site; inhibition site 1211025001848 active site 1211025001849 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1211025001850 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1211025001851 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1211025001852 Bacterial transcriptional regulator; Region: IclR; pfam01614 1211025001853 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1211025001854 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1211025001855 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1211025001856 RNase E inhibitor protein; Provisional; Region: PRK11191 1211025001857 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1211025001858 active site 1211025001859 dinuclear metal binding site [ion binding]; other site 1211025001860 dimerization interface [polypeptide binding]; other site 1211025001861 integrase; Provisional; Region: PRK09692 1211025001862 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1211025001863 active site 1211025001864 Int/Topo IB signature motif; other site 1211025001865 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 1211025001866 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 1211025001867 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1211025001868 TIGR02687 family protein; Region: TIGR02687 1211025001869 PglZ domain; Region: PglZ; pfam08665 1211025001870 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1211025001871 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1211025001872 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1211025001873 putative active site [active] 1211025001874 putative NTP binding site [chemical binding]; other site 1211025001875 putative nucleic acid binding site [nucleotide binding]; other site 1211025001876 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1211025001877 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1211025001878 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1211025001879 Protein of unknown function DUF262; Region: DUF262; pfam03235 1211025001880 Protein of unknown function DUF262; Region: DUF262; pfam03235 1211025001881 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1211025001882 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 1211025001883 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 1211025001884 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1211025001885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1211025001886 active site 1211025001887 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1211025001888 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1211025001889 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 1211025001890 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1211025001891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025001892 S-adenosylmethionine binding site [chemical binding]; other site 1211025001893 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1211025001894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025001895 Coenzyme A binding pocket [chemical binding]; other site 1211025001896 hypothetical protein; Provisional; Region: PRK13687 1211025001897 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1211025001898 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1211025001899 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1211025001900 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1211025001901 putative ligand binding site [chemical binding]; other site 1211025001902 putative NAD binding site [chemical binding]; other site 1211025001903 catalytic site [active] 1211025001904 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1211025001905 classical (c) SDRs; Region: SDR_c; cd05233 1211025001906 NAD(P) binding site [chemical binding]; other site 1211025001907 active site 1211025001908 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1211025001909 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1211025001910 putative N- and C-terminal domain interface [polypeptide binding]; other site 1211025001911 putative active site [active] 1211025001912 MgATP binding site [chemical binding]; other site 1211025001913 catalytic site [active] 1211025001914 metal binding site [ion binding]; metal-binding site 1211025001915 putative xylulose binding site [chemical binding]; other site 1211025001916 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1211025001917 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1211025001918 Class I aldolases; Region: Aldolase_Class_I; cl17187 1211025001919 catalytic residue [active] 1211025001920 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1211025001921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1211025001922 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1211025001923 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1211025001924 substrate binding site [chemical binding]; other site 1211025001925 active site 1211025001926 catalytic residues [active] 1211025001927 heterodimer interface [polypeptide binding]; other site 1211025001928 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1211025001929 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1211025001930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025001931 catalytic residue [active] 1211025001932 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1211025001933 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1211025001934 DNA binding residues [nucleotide binding] 1211025001935 drug binding residues [chemical binding]; other site 1211025001936 dimer interface [polypeptide binding]; other site 1211025001937 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1211025001938 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1211025001939 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 1211025001940 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1211025001941 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1211025001942 Predicted GTPase [General function prediction only]; Region: COG3596 1211025001943 YfjP GTPase; Region: YfjP; cd11383 1211025001944 G1 box; other site 1211025001945 GTP/Mg2+ binding site [chemical binding]; other site 1211025001946 Switch I region; other site 1211025001947 G2 box; other site 1211025001948 Switch II region; other site 1211025001949 G3 box; other site 1211025001950 G4 box; other site 1211025001951 G5 box; other site 1211025001952 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1211025001953 Antirestriction protein; Region: Antirestrict; pfam03230 1211025001954 hypothetical protein; Reviewed; Region: PRK00024 1211025001955 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1211025001956 MPN+ (JAMM) motif; other site 1211025001957 Zinc-binding site [ion binding]; other site 1211025001958 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1211025001959 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1211025001960 HNH endonuclease; Region: HNH_2; pfam13391 1211025001961 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1211025001962 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1211025001963 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1211025001964 PAAR motif; Region: PAAR_motif; pfam05488 1211025001965 S-type Pyocin; Region: Pyocin_S; pfam06958 1211025001966 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1211025001967 active site 1211025001968 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1211025001969 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1211025001970 active site 1211025001971 HIGH motif; other site 1211025001972 dimer interface [polypeptide binding]; other site 1211025001973 KMSKS motif; other site 1211025001974 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1211025001975 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1211025001976 dimer interface [polypeptide binding]; other site 1211025001977 Mn binding site [ion binding]; other site 1211025001978 K binding site [ion binding]; other site 1211025001979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025001980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025001981 DNA binding site [nucleotide binding] 1211025001982 domain linker motif; other site 1211025001983 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1211025001984 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1211025001985 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1211025001986 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1211025001987 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1211025001988 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1211025001989 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1211025001990 Transmembrane secretion effector; Region: MFS_3; pfam05977 1211025001991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025001992 putative substrate translocation pore; other site 1211025001993 DoxX; Region: DoxX; pfam07681 1211025001994 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1211025001995 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1211025001996 active site 1211025001997 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1211025001998 Isochorismatase family; Region: Isochorismatase; pfam00857 1211025001999 catalytic triad [active] 1211025002000 dimer interface [polypeptide binding]; other site 1211025002001 conserved cis-peptide bond; other site 1211025002002 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 1211025002003 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1211025002004 Response regulator receiver domain; Region: Response_reg; pfam00072 1211025002005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025002006 active site 1211025002007 phosphorylation site [posttranslational modification] 1211025002008 intermolecular recognition site; other site 1211025002009 dimerization interface [polypeptide binding]; other site 1211025002010 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1211025002011 substrate binding site [chemical binding]; other site 1211025002012 activation loop (A-loop); other site 1211025002013 AAA ATPase domain; Region: AAA_16; pfam13191 1211025002014 Predicted ATPase [General function prediction only]; Region: COG3899 1211025002015 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1211025002016 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1211025002017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025002018 PAS fold; Region: PAS; pfam00989 1211025002019 putative active site [active] 1211025002020 heme pocket [chemical binding]; other site 1211025002021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025002022 ATP binding site [chemical binding]; other site 1211025002023 Mg2+ binding site [ion binding]; other site 1211025002024 G-X-G motif; other site 1211025002025 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1211025002026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025002027 active site 1211025002028 phosphorylation site [posttranslational modification] 1211025002029 intermolecular recognition site; other site 1211025002030 dimerization interface [polypeptide binding]; other site 1211025002031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025002032 DNA binding residues [nucleotide binding] 1211025002033 dimerization interface [polypeptide binding]; other site 1211025002034 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1211025002035 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1211025002036 oligomer interface [polypeptide binding]; other site 1211025002037 active site residues [active] 1211025002038 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1211025002039 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1211025002040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025002041 DNA-binding site [nucleotide binding]; DNA binding site 1211025002042 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025002043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025002044 homodimer interface [polypeptide binding]; other site 1211025002045 catalytic residue [active] 1211025002046 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1211025002047 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1211025002048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025002049 DNA-binding site [nucleotide binding]; DNA binding site 1211025002050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025002051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025002052 homodimer interface [polypeptide binding]; other site 1211025002053 catalytic residue [active] 1211025002054 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1211025002055 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1211025002056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025002057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025002058 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1211025002059 putative effector binding pocket; other site 1211025002060 putative dimerization interface [polypeptide binding]; other site 1211025002061 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1211025002062 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1211025002063 NAD binding site [chemical binding]; other site 1211025002064 catalytic residues [active] 1211025002065 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1211025002066 ACT domain-containing protein [General function prediction only]; Region: COG4747 1211025002067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1211025002068 dimerization interface [polypeptide binding]; other site 1211025002069 putative DNA binding site [nucleotide binding]; other site 1211025002070 putative Zn2+ binding site [ion binding]; other site 1211025002071 transcriptional regulator SlyA; Provisional; Region: PRK03573 1211025002072 MarR family; Region: MarR_2; cl17246 1211025002073 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1211025002074 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025002075 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025002076 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1211025002077 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1211025002078 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1211025002079 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1211025002080 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1211025002081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025002082 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1211025002083 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1211025002084 NAD(P) binding site [chemical binding]; other site 1211025002085 catalytic residues [active] 1211025002086 YfaZ precursor; Region: YfaZ; pfam07437 1211025002087 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1211025002088 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1211025002089 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1211025002090 P-loop, Walker A motif; other site 1211025002091 Base recognition motif; other site 1211025002092 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1211025002093 Uncharacterized small protein [Function unknown]; Region: COG2879 1211025002094 carbon starvation protein A; Provisional; Region: PRK15015 1211025002095 Carbon starvation protein CstA; Region: CstA; pfam02554 1211025002096 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1211025002097 potential frameshift: common BLAST hit: gi|365968845|ref|YP_004950406.1| transcriptional Regulator 1211025002098 Flavin Reductases; Region: FlaRed; cl00801 1211025002099 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1211025002100 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1211025002101 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1211025002102 Cupin domain; Region: Cupin_2; pfam07883 1211025002103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025002104 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1211025002105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025002106 putative substrate translocation pore; other site 1211025002107 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1211025002108 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1211025002109 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1211025002110 putative substrate binding pocket [chemical binding]; other site 1211025002111 trimer interface [polypeptide binding]; other site 1211025002112 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1211025002113 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1211025002114 putative active site [active] 1211025002115 putative metal binding site [ion binding]; other site 1211025002116 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1211025002117 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1211025002118 NAD binding site [chemical binding]; other site 1211025002119 catalytic residues [active] 1211025002120 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 1211025002121 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1211025002122 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1211025002123 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1211025002124 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1211025002125 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1211025002126 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1211025002127 dimer interface [polypeptide binding]; other site 1211025002128 ligand binding site [chemical binding]; other site 1211025002129 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025002130 dimerization interface [polypeptide binding]; other site 1211025002131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025002132 dimer interface [polypeptide binding]; other site 1211025002133 putative CheW interface [polypeptide binding]; other site 1211025002134 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1211025002135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025002136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1211025002137 Coenzyme A binding pocket [chemical binding]; other site 1211025002138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1211025002139 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1211025002140 DNA binding site [nucleotide binding] 1211025002141 Spore Coat Protein U domain; Region: SCPU; pfam05229 1211025002142 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1211025002143 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025002144 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025002145 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1211025002146 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025002147 Spore Coat Protein U domain; Region: SCPU; pfam05229 1211025002148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025002149 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1211025002150 DNA binding residues [nucleotide binding] 1211025002151 dimerization interface [polypeptide binding]; other site 1211025002152 EAL domain; Region: EAL; pfam00563 1211025002153 phosphoglycerol transferase I; Provisional; Region: PRK03776 1211025002154 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1211025002155 hypothetical protein; Provisional; Region: PRK11667 1211025002156 DNA replication protein DnaC; Validated; Region: PRK07952 1211025002157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025002158 Walker A motif; other site 1211025002159 ATP binding site [chemical binding]; other site 1211025002160 Walker B motif; other site 1211025002161 primosomal protein DnaI; Provisional; Region: PRK02854 1211025002162 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1211025002163 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1211025002164 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1211025002165 putative Zn2+ binding site [ion binding]; other site 1211025002166 putative DNA binding site [nucleotide binding]; other site 1211025002167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025002168 hypothetical protein; Provisional; Region: PRK09917 1211025002169 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1211025002170 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1211025002171 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1211025002172 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025002173 DNA binding residues [nucleotide binding] 1211025002174 dimerization interface [polypeptide binding]; other site 1211025002175 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1211025002176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025002177 DNA binding residues [nucleotide binding] 1211025002178 dimerization interface [polypeptide binding]; other site 1211025002179 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1211025002180 putative deacylase active site [active] 1211025002181 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1211025002182 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1211025002183 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1211025002184 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1211025002185 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1211025002186 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025002187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025002188 metal binding site [ion binding]; metal-binding site 1211025002189 active site 1211025002190 I-site; other site 1211025002191 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1211025002192 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1211025002193 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1211025002194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025002195 S-adenosylmethionine binding site [chemical binding]; other site 1211025002196 DNA polymerase III subunit psi; Validated; Region: PRK06856 1211025002197 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1211025002198 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1211025002199 dUMP phosphatase; Provisional; Region: PRK09449 1211025002200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025002201 motif II; other site 1211025002202 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1211025002203 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1211025002204 G1 box; other site 1211025002205 putative GEF interaction site [polypeptide binding]; other site 1211025002206 GTP/Mg2+ binding site [chemical binding]; other site 1211025002207 Switch I region; other site 1211025002208 G2 box; other site 1211025002209 G3 box; other site 1211025002210 Switch II region; other site 1211025002211 G4 box; other site 1211025002212 G5 box; other site 1211025002213 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1211025002214 periplasmic protein; Provisional; Region: PRK10568 1211025002215 BON domain; Region: BON; pfam04972 1211025002216 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1211025002217 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1211025002218 active site 1211025002219 nucleophile elbow; other site 1211025002220 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1211025002221 active site 1211025002222 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1211025002223 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1211025002224 hypothetical protein; Provisional; Region: PRK10977 1211025002225 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1211025002226 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1211025002227 intersubunit interface [polypeptide binding]; other site 1211025002228 active site 1211025002229 catalytic residue [active] 1211025002230 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1211025002231 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1211025002232 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1211025002233 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1211025002234 phosphopentomutase; Provisional; Region: PRK05362 1211025002235 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1211025002236 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1211025002237 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1211025002238 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1211025002239 hypothetical protein; Provisional; Region: PRK15301 1211025002240 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1211025002241 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025002242 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025002243 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025002244 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1211025002245 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025002246 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025002247 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1211025002248 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1211025002249 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1211025002250 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1211025002251 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1211025002252 hypothetical protein; Provisional; Region: PRK11246 1211025002253 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1211025002254 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1211025002255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025002256 motif II; other site 1211025002257 DNA repair protein RadA; Region: sms; TIGR00416 1211025002258 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1211025002259 Walker A motif/ATP binding site; other site 1211025002260 ATP binding site [chemical binding]; other site 1211025002261 Walker B motif; other site 1211025002262 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1211025002263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025002264 non-specific DNA binding site [nucleotide binding]; other site 1211025002265 salt bridge; other site 1211025002266 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1211025002267 sequence-specific DNA binding site [nucleotide binding]; other site 1211025002268 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1211025002269 active site 1211025002270 (T/H)XGH motif; other site 1211025002271 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1211025002272 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1211025002273 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1211025002274 putative NAD(P) binding site [chemical binding]; other site 1211025002275 dimer interface [polypeptide binding]; other site 1211025002276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025002277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025002278 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1211025002279 putative effector binding pocket; other site 1211025002280 dimerization interface [polypeptide binding]; other site 1211025002281 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1211025002282 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025002283 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025002284 ABC transporter; Region: ABC_tran_2; pfam12848 1211025002285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025002286 lytic murein transglycosylase; Provisional; Region: PRK11619 1211025002287 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1211025002288 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1211025002289 catalytic residue [active] 1211025002290 Trp operon repressor; Provisional; Region: PRK01381 1211025002291 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1211025002292 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1211025002293 catalytic core [active] 1211025002294 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1211025002295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025002296 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1211025002297 hypothetical protein; Provisional; Region: PRK10756 1211025002298 CreA protein; Region: CreA; pfam05981 1211025002299 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1211025002300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025002301 active site 1211025002302 phosphorylation site [posttranslational modification] 1211025002303 intermolecular recognition site; other site 1211025002304 dimerization interface [polypeptide binding]; other site 1211025002305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025002306 DNA binding site [nucleotide binding] 1211025002307 sensory histidine kinase CreC; Provisional; Region: PRK11100 1211025002308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025002309 dimer interface [polypeptide binding]; other site 1211025002310 phosphorylation site [posttranslational modification] 1211025002311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025002312 ATP binding site [chemical binding]; other site 1211025002313 Mg2+ binding site [ion binding]; other site 1211025002314 G-X-G motif; other site 1211025002315 Inner membrane protein CreD; Region: CreD; cl01844 1211025002316 two-component response regulator; Provisional; Region: PRK11173 1211025002317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025002318 active site 1211025002319 phosphorylation site [posttranslational modification] 1211025002320 intermolecular recognition site; other site 1211025002321 dimerization interface [polypeptide binding]; other site 1211025002322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025002323 DNA binding site [nucleotide binding] 1211025002324 putative RNA methyltransferase; Provisional; Region: PRK10433 1211025002325 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1211025002326 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1211025002327 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1211025002328 putative catalytic residues [active] 1211025002329 putative nucleotide binding site [chemical binding]; other site 1211025002330 putative aspartate binding site [chemical binding]; other site 1211025002331 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1211025002332 dimer interface [polypeptide binding]; other site 1211025002333 putative threonine allosteric regulatory site; other site 1211025002334 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1211025002335 putative threonine allosteric regulatory site; other site 1211025002336 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1211025002337 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1211025002338 homoserine kinase; Provisional; Region: PRK01212 1211025002339 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1211025002340 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1211025002341 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1211025002342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025002343 catalytic residue [active] 1211025002344 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1211025002345 hypothetical protein; Validated; Region: PRK02101 1211025002346 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1211025002347 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1211025002348 transaldolase-like protein; Provisional; Region: PTZ00411 1211025002349 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1211025002350 active site 1211025002351 dimer interface [polypeptide binding]; other site 1211025002352 catalytic residue [active] 1211025002353 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1211025002354 MPT binding site; other site 1211025002355 trimer interface [polypeptide binding]; other site 1211025002356 metabolite-proton symporter; Region: 2A0106; TIGR00883 1211025002357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025002358 putative substrate translocation pore; other site 1211025002359 hypothetical protein; Provisional; Region: PRK10659 1211025002360 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1211025002361 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1211025002362 nucleotide binding site [chemical binding]; other site 1211025002363 chaperone protein DnaJ; Provisional; Region: PRK10767 1211025002364 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1211025002365 HSP70 interaction site [polypeptide binding]; other site 1211025002366 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1211025002367 substrate binding site [polypeptide binding]; other site 1211025002368 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1211025002369 Zn binding sites [ion binding]; other site 1211025002370 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1211025002371 dimer interface [polypeptide binding]; other site 1211025002372 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1211025002373 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1211025002374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025002375 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1211025002376 putative dimerization interface [polypeptide binding]; other site 1211025002377 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1211025002378 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1211025002379 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1211025002380 active site 1211025002381 Riboflavin kinase; Region: Flavokinase; smart00904 1211025002382 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1211025002383 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1211025002384 HIGH motif; other site 1211025002385 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1211025002386 active site 1211025002387 KMSKS motif; other site 1211025002388 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1211025002389 tRNA binding surface [nucleotide binding]; other site 1211025002390 anticodon binding site; other site 1211025002391 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1211025002392 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1211025002393 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1211025002394 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1211025002395 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1211025002396 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1211025002397 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1211025002398 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1211025002399 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1211025002400 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1211025002401 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1211025002402 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1211025002403 catalytic site [active] 1211025002404 subunit interface [polypeptide binding]; other site 1211025002405 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1211025002406 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1211025002407 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1211025002408 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1211025002409 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1211025002410 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1211025002411 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1211025002412 IMP binding site; other site 1211025002413 dimer interface [polypeptide binding]; other site 1211025002414 interdomain contacts; other site 1211025002415 partial ornithine binding site; other site 1211025002416 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1211025002417 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1211025002418 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1211025002419 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1211025002420 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1211025002421 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1211025002422 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1211025002423 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1211025002424 TrkA-N domain; Region: TrkA_N; pfam02254 1211025002425 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1211025002426 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1211025002427 folate binding site [chemical binding]; other site 1211025002428 NADP+ binding site [chemical binding]; other site 1211025002429 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1211025002430 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1211025002431 active site 1211025002432 metal binding site [ion binding]; metal-binding site 1211025002433 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1211025002434 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1211025002435 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1211025002436 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1211025002437 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1211025002438 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1211025002439 SurA N-terminal domain; Region: SurA_N; pfam09312 1211025002440 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1211025002441 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1211025002442 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1211025002443 OstA-like protein; Region: OstA; pfam03968 1211025002444 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1211025002445 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1211025002446 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1211025002447 putative metal binding site [ion binding]; other site 1211025002448 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1211025002449 HSP70 interaction site [polypeptide binding]; other site 1211025002450 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1211025002451 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1211025002452 active site 1211025002453 ATP-dependent helicase HepA; Validated; Region: PRK04914 1211025002454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025002455 ATP binding site [chemical binding]; other site 1211025002456 putative Mg++ binding site [ion binding]; other site 1211025002457 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025002458 nucleotide binding region [chemical binding]; other site 1211025002459 ATP-binding site [chemical binding]; other site 1211025002460 DNA polymerase II; Reviewed; Region: PRK05762 1211025002461 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1211025002462 active site 1211025002463 catalytic site [active] 1211025002464 substrate binding site [chemical binding]; other site 1211025002465 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1211025002466 active site 1211025002467 metal-binding site 1211025002468 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1211025002469 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1211025002470 intersubunit interface [polypeptide binding]; other site 1211025002471 active site 1211025002472 Zn2+ binding site [ion binding]; other site 1211025002473 L-arabinose isomerase; Provisional; Region: PRK02929 1211025002474 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1211025002475 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1211025002476 trimer interface [polypeptide binding]; other site 1211025002477 putative substrate binding site [chemical binding]; other site 1211025002478 putative metal binding site [ion binding]; other site 1211025002479 ribulokinase; Provisional; Region: PRK04123 1211025002480 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1211025002481 N- and C-terminal domain interface [polypeptide binding]; other site 1211025002482 active site 1211025002483 MgATP binding site [chemical binding]; other site 1211025002484 catalytic site [active] 1211025002485 metal binding site [ion binding]; metal-binding site 1211025002486 carbohydrate binding site [chemical binding]; other site 1211025002487 homodimer interface [polypeptide binding]; other site 1211025002488 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1211025002489 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1211025002490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025002491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025002492 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1211025002493 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1211025002494 PAAR motif; Region: PAAR_motif; pfam05488 1211025002495 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 1211025002496 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1211025002497 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1211025002498 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1211025002499 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1211025002500 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1211025002501 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1211025002502 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1211025002503 Walker A/P-loop; other site 1211025002504 ATP binding site [chemical binding]; other site 1211025002505 Q-loop/lid; other site 1211025002506 ABC transporter signature motif; other site 1211025002507 Walker B; other site 1211025002508 D-loop; other site 1211025002509 H-loop/switch region; other site 1211025002510 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1211025002511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025002512 dimer interface [polypeptide binding]; other site 1211025002513 conserved gate region; other site 1211025002514 putative PBP binding loops; other site 1211025002515 ABC-ATPase subunit interface; other site 1211025002516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025002517 dimer interface [polypeptide binding]; other site 1211025002518 conserved gate region; other site 1211025002519 putative PBP binding loops; other site 1211025002520 ABC-ATPase subunit interface; other site 1211025002521 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1211025002522 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1211025002523 transcriptional regulator SgrR; Provisional; Region: PRK13626 1211025002524 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1211025002525 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1211025002526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025002527 sugar efflux transporter; Region: 2A0120; TIGR00899 1211025002528 putative substrate translocation pore; other site 1211025002529 Hok/gef family; Region: HOK_GEF; pfam01848 1211025002530 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1211025002531 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1211025002532 substrate binding site [chemical binding]; other site 1211025002533 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1211025002534 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1211025002535 substrate binding site [chemical binding]; other site 1211025002536 ligand binding site [chemical binding]; other site 1211025002537 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1211025002538 tartrate dehydrogenase; Region: TTC; TIGR02089 1211025002539 2-isopropylmalate synthase; Validated; Region: PRK00915 1211025002540 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1211025002541 active site 1211025002542 catalytic residues [active] 1211025002543 metal binding site [ion binding]; metal-binding site 1211025002544 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1211025002545 potential frameshift: common BLAST hit: gi|296101239|ref|YP_003611385.1| leucine transcriptional activator 1211025002546 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1211025002547 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1211025002548 PYR/PP interface [polypeptide binding]; other site 1211025002549 dimer interface [polypeptide binding]; other site 1211025002550 TPP binding site [chemical binding]; other site 1211025002551 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1211025002552 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1211025002553 TPP-binding site [chemical binding]; other site 1211025002554 dimer interface [polypeptide binding]; other site 1211025002555 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1211025002556 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1211025002557 putative valine binding site [chemical binding]; other site 1211025002558 dimer interface [polypeptide binding]; other site 1211025002559 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1211025002560 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1211025002561 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025002562 DNA binding site [nucleotide binding] 1211025002563 domain linker motif; other site 1211025002564 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1211025002565 dimerization interface [polypeptide binding]; other site 1211025002566 ligand binding site [chemical binding]; other site 1211025002567 mraZ protein; Region: TIGR00242 1211025002568 MraZ protein; Region: MraZ; pfam02381 1211025002569 MraZ protein; Region: MraZ; pfam02381 1211025002570 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1211025002571 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1211025002572 cell division protein FtsL; Provisional; Region: PRK10772 1211025002573 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1211025002574 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1211025002575 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1211025002576 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1211025002577 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1211025002578 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1211025002579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1211025002580 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1211025002581 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1211025002582 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1211025002583 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1211025002584 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1211025002585 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1211025002586 Mg++ binding site [ion binding]; other site 1211025002587 putative catalytic motif [active] 1211025002588 putative substrate binding site [chemical binding]; other site 1211025002589 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1211025002590 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1211025002591 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1211025002592 cell division protein FtsW; Provisional; Region: PRK10774 1211025002593 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1211025002594 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1211025002595 active site 1211025002596 homodimer interface [polypeptide binding]; other site 1211025002597 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1211025002598 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1211025002599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1211025002600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1211025002601 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1211025002602 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1211025002603 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1211025002604 cell division protein FtsQ; Provisional; Region: PRK10775 1211025002605 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1211025002606 Cell division protein FtsQ; Region: FtsQ; pfam03799 1211025002607 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1211025002608 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1211025002609 Cell division protein FtsA; Region: FtsA; pfam14450 1211025002610 cell division protein FtsZ; Validated; Region: PRK09330 1211025002611 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1211025002612 nucleotide binding site [chemical binding]; other site 1211025002613 SulA interaction site; other site 1211025002614 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1211025002615 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1211025002616 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1211025002617 SecA regulator SecM; Provisional; Region: PRK02943 1211025002618 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1211025002619 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1211025002620 SEC-C motif; Region: SEC-C; pfam02810 1211025002621 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1211025002622 active site 1211025002623 8-oxo-dGMP binding site [chemical binding]; other site 1211025002624 nudix motif; other site 1211025002625 metal binding site [ion binding]; metal-binding site 1211025002626 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1211025002627 hypothetical protein; Provisional; Region: PRK05287 1211025002628 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1211025002629 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1211025002630 CoA-binding site [chemical binding]; other site 1211025002631 ATP-binding [chemical binding]; other site 1211025002632 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1211025002633 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1211025002634 active site 1211025002635 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1211025002636 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1211025002637 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1211025002638 hypothetical protein; Provisional; Region: PRK10436 1211025002639 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1211025002640 Walker A motif; other site 1211025002641 ATP binding site [chemical binding]; other site 1211025002642 Walker B motif; other site 1211025002643 putative major pilin subunit; Provisional; Region: PRK10574 1211025002644 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1211025002645 Pilin (bacterial filament); Region: Pilin; pfam00114 1211025002646 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1211025002647 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1211025002648 dimerization interface [polypeptide binding]; other site 1211025002649 active site 1211025002650 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1211025002651 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1211025002652 amidase catalytic site [active] 1211025002653 Zn binding residues [ion binding]; other site 1211025002654 substrate binding site [chemical binding]; other site 1211025002655 regulatory protein AmpE; Provisional; Region: PRK10987 1211025002656 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1211025002657 active site 1211025002658 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1211025002659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025002660 putative substrate translocation pore; other site 1211025002661 aromatic amino acid transporter; Provisional; Region: PRK10238 1211025002662 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1211025002663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025002664 DNA-binding site [nucleotide binding]; DNA binding site 1211025002665 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1211025002666 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1211025002667 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1211025002668 dimer interface [polypeptide binding]; other site 1211025002669 TPP-binding site [chemical binding]; other site 1211025002670 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1211025002671 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1211025002672 E3 interaction surface; other site 1211025002673 lipoyl attachment site [posttranslational modification]; other site 1211025002674 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1211025002675 E3 interaction surface; other site 1211025002676 lipoyl attachment site [posttranslational modification]; other site 1211025002677 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1211025002678 E3 interaction surface; other site 1211025002679 lipoyl attachment site [posttranslational modification]; other site 1211025002680 e3 binding domain; Region: E3_binding; pfam02817 1211025002681 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1211025002682 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1211025002683 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1211025002684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025002685 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1211025002686 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 1211025002687 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 1211025002688 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1211025002689 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1211025002690 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1211025002691 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1211025002692 substrate binding site [chemical binding]; other site 1211025002693 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1211025002694 substrate binding site [chemical binding]; other site 1211025002695 ligand binding site [chemical binding]; other site 1211025002696 hypothetical protein; Provisional; Region: PRK05248 1211025002697 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1211025002698 catalytic residues [active] 1211025002699 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 1211025002700 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 1211025002701 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1211025002702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1211025002703 active site 1211025002704 phosphorylation site [posttranslational modification] 1211025002705 intermolecular recognition site; other site 1211025002706 dimerization interface [polypeptide binding]; other site 1211025002707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025002708 DNA binding residues [nucleotide binding] 1211025002709 dimerization interface [polypeptide binding]; other site 1211025002710 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1211025002711 spermidine synthase; Provisional; Region: PRK00811 1211025002712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025002713 S-adenosylmethionine binding site [chemical binding]; other site 1211025002714 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1211025002715 multicopper oxidase; Provisional; Region: PRK10965 1211025002716 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1211025002717 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1211025002718 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1211025002719 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1211025002720 Trp docking motif [polypeptide binding]; other site 1211025002721 putative active site [active] 1211025002722 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1211025002723 active site 1211025002724 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1211025002725 active site clefts [active] 1211025002726 zinc binding site [ion binding]; other site 1211025002727 dimer interface [polypeptide binding]; other site 1211025002728 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1211025002729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025002730 Q-loop/lid; other site 1211025002731 ABC transporter signature motif; other site 1211025002732 Walker B; other site 1211025002733 D-loop; other site 1211025002734 H-loop/switch region; other site 1211025002735 inner membrane transport permease; Provisional; Region: PRK15066 1211025002736 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1211025002737 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1211025002738 active pocket/dimerization site; other site 1211025002739 active site 1211025002740 phosphorylation site [posttranslational modification] 1211025002741 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1211025002742 putative active site [active] 1211025002743 putative metal binding site [ion binding]; other site 1211025002744 Fimbrial protein; Region: Fimbrial; cl01416 1211025002745 Fimbrial protein; Region: Fimbrial; cl01416 1211025002746 putative fimbrial protein StaE; Provisional; Region: PRK15263 1211025002747 Fimbrial protein; Region: Fimbrial; cl01416 1211025002748 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1211025002749 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025002750 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025002751 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025002752 putative chaperone protein EcpD; Provisional; Region: PRK09926 1211025002753 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025002754 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025002755 Fimbrial protein; Region: Fimbrial; cl01416 1211025002756 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1211025002757 tetramerization interface [polypeptide binding]; other site 1211025002758 active site 1211025002759 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1211025002760 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1211025002761 active site 1211025002762 ATP-binding site [chemical binding]; other site 1211025002763 pantoate-binding site; other site 1211025002764 HXXH motif; other site 1211025002765 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1211025002766 oligomerization interface [polypeptide binding]; other site 1211025002767 active site 1211025002768 metal binding site [ion binding]; metal-binding site 1211025002769 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1211025002770 catalytic center binding site [active] 1211025002771 ATP binding site [chemical binding]; other site 1211025002772 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1211025002773 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1211025002774 active site 1211025002775 NTP binding site [chemical binding]; other site 1211025002776 metal binding triad [ion binding]; metal-binding site 1211025002777 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1211025002778 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1211025002779 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1211025002780 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1211025002781 active site 1211025002782 nucleotide binding site [chemical binding]; other site 1211025002783 HIGH motif; other site 1211025002784 KMSKS motif; other site 1211025002785 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1211025002786 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1211025002787 2'-5' RNA ligase; Provisional; Region: PRK15124 1211025002788 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1211025002789 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1211025002790 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1211025002791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025002792 ATP binding site [chemical binding]; other site 1211025002793 putative Mg++ binding site [ion binding]; other site 1211025002794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025002795 nucleotide binding region [chemical binding]; other site 1211025002796 ATP-binding site [chemical binding]; other site 1211025002797 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1211025002798 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1211025002799 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1211025002800 Transglycosylase; Region: Transgly; pfam00912 1211025002801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1211025002802 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1211025002803 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1211025002804 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025002805 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025002806 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1211025002807 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025002808 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025002809 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025002810 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1211025002811 Fimbrial protein; Region: Fimbrial; pfam00419 1211025002812 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1211025002813 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025002814 N-terminal plug; other site 1211025002815 ligand-binding site [chemical binding]; other site 1211025002816 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1211025002817 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1211025002818 Walker A/P-loop; other site 1211025002819 ATP binding site [chemical binding]; other site 1211025002820 Q-loop/lid; other site 1211025002821 ABC transporter signature motif; other site 1211025002822 Walker B; other site 1211025002823 D-loop; other site 1211025002824 H-loop/switch region; other site 1211025002825 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1211025002826 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1211025002827 siderophore binding site; other site 1211025002828 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1211025002829 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025002830 ABC-ATPase subunit interface; other site 1211025002831 dimer interface [polypeptide binding]; other site 1211025002832 putative PBP binding regions; other site 1211025002833 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025002834 ABC-ATPase subunit interface; other site 1211025002835 dimer interface [polypeptide binding]; other site 1211025002836 putative PBP binding regions; other site 1211025002837 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1211025002838 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1211025002839 inhibitor-cofactor binding pocket; inhibition site 1211025002840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025002841 catalytic residue [active] 1211025002842 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1211025002843 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1211025002844 Cl- selectivity filter; other site 1211025002845 Cl- binding residues [ion binding]; other site 1211025002846 pore gating glutamate residue; other site 1211025002847 dimer interface [polypeptide binding]; other site 1211025002848 H+/Cl- coupling transport residue; other site 1211025002849 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1211025002850 hypothetical protein; Provisional; Region: PRK10578 1211025002851 UPF0126 domain; Region: UPF0126; pfam03458 1211025002852 UPF0126 domain; Region: UPF0126; pfam03458 1211025002853 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1211025002854 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1211025002855 cobalamin binding residues [chemical binding]; other site 1211025002856 putative BtuC binding residues; other site 1211025002857 dimer interface [polypeptide binding]; other site 1211025002858 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1211025002859 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1211025002860 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1211025002861 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1211025002862 Zn2+ binding site [ion binding]; other site 1211025002863 Mg2+ binding site [ion binding]; other site 1211025002864 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1211025002865 serine endoprotease; Provisional; Region: PRK10942 1211025002866 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1211025002867 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1211025002868 protein binding site [polypeptide binding]; other site 1211025002869 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1211025002870 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1211025002871 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1211025002872 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1211025002873 hypothetical protein; Provisional; Region: PRK13677 1211025002874 Helix-turn-helix domain; Region: HTH_39; pfam14090 1211025002875 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1211025002876 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1211025002877 trimer interface [polypeptide binding]; other site 1211025002878 active site 1211025002879 substrate binding site [chemical binding]; other site 1211025002880 CoA binding site [chemical binding]; other site 1211025002881 PII uridylyl-transferase; Provisional; Region: PRK05007 1211025002882 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1211025002883 metal binding triad; other site 1211025002884 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1211025002885 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1211025002886 Zn2+ binding site [ion binding]; other site 1211025002887 Mg2+ binding site [ion binding]; other site 1211025002888 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1211025002889 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1211025002890 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1211025002891 active site 1211025002892 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1211025002893 rRNA interaction site [nucleotide binding]; other site 1211025002894 S8 interaction site; other site 1211025002895 putative laminin-1 binding site; other site 1211025002896 elongation factor Ts; Provisional; Region: tsf; PRK09377 1211025002897 UBA/TS-N domain; Region: UBA; pfam00627 1211025002898 Elongation factor TS; Region: EF_TS; pfam00889 1211025002899 Elongation factor TS; Region: EF_TS; pfam00889 1211025002900 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1211025002901 putative nucleotide binding site [chemical binding]; other site 1211025002902 uridine monophosphate binding site [chemical binding]; other site 1211025002903 homohexameric interface [polypeptide binding]; other site 1211025002904 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1211025002905 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1211025002906 hinge region; other site 1211025002907 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1211025002908 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1211025002909 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1211025002910 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1211025002911 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1211025002912 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1211025002913 catalytic residue [active] 1211025002914 putative FPP diphosphate binding site; other site 1211025002915 putative FPP binding hydrophobic cleft; other site 1211025002916 dimer interface [polypeptide binding]; other site 1211025002917 putative IPP diphosphate binding site; other site 1211025002918 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1211025002919 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1211025002920 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1211025002921 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1211025002922 active site 1211025002923 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1211025002924 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1211025002925 protein binding site [polypeptide binding]; other site 1211025002926 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1211025002927 putative substrate binding region [chemical binding]; other site 1211025002928 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1211025002929 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1211025002930 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1211025002931 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1211025002932 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1211025002933 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1211025002934 Surface antigen; Region: Bac_surface_Ag; pfam01103 1211025002935 periplasmic chaperone; Provisional; Region: PRK10780 1211025002936 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1211025002937 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1211025002938 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1211025002939 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1211025002940 trimer interface [polypeptide binding]; other site 1211025002941 active site 1211025002942 UDP-GlcNAc binding site [chemical binding]; other site 1211025002943 lipid binding site [chemical binding]; lipid-binding site 1211025002944 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1211025002945 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1211025002946 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1211025002947 active site 1211025002948 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1211025002949 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1211025002950 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1211025002951 RNA/DNA hybrid binding site [nucleotide binding]; other site 1211025002952 active site 1211025002953 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1211025002954 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1211025002955 putative active site [active] 1211025002956 putative PHP Thumb interface [polypeptide binding]; other site 1211025002957 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1211025002958 generic binding surface II; other site 1211025002959 generic binding surface I; other site 1211025002960 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1211025002961 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1211025002962 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1211025002963 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1211025002964 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1211025002965 homodimer interface [polypeptide binding]; other site 1211025002966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025002967 catalytic residue [active] 1211025002968 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1211025002969 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1211025002970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1211025002971 putative metal binding site [ion binding]; other site 1211025002972 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1211025002973 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1211025002974 Ligand Binding Site [chemical binding]; other site 1211025002975 TilS substrate binding domain; Region: TilS; pfam09179 1211025002976 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1211025002977 Rho-binding antiterminator; Provisional; Region: PRK11625 1211025002978 hypothetical protein; Provisional; Region: PRK04964 1211025002979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1211025002980 hypothetical protein; Provisional; Region: PRK09256 1211025002981 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1211025002982 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1211025002983 NlpE N-terminal domain; Region: NlpE; pfam04170 1211025002984 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1211025002985 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1211025002986 dimer interface [polypeptide binding]; other site 1211025002987 motif 1; other site 1211025002988 active site 1211025002989 motif 2; other site 1211025002990 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1211025002991 putative deacylase active site [active] 1211025002992 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1211025002993 active site 1211025002994 motif 3; other site 1211025002995 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1211025002996 anticodon binding site; other site 1211025002997 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1211025002998 homodimer interaction site [polypeptide binding]; other site 1211025002999 cofactor binding site; other site 1211025003000 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1211025003001 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1211025003002 lipoprotein, YaeC family; Region: TIGR00363 1211025003003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025003004 dimer interface [polypeptide binding]; other site 1211025003005 conserved gate region; other site 1211025003006 ABC-ATPase subunit interface; other site 1211025003007 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1211025003008 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1211025003009 Walker A/P-loop; other site 1211025003010 ATP binding site [chemical binding]; other site 1211025003011 Q-loop/lid; other site 1211025003012 ABC transporter signature motif; other site 1211025003013 Walker B; other site 1211025003014 D-loop; other site 1211025003015 H-loop/switch region; other site 1211025003016 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1211025003017 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1211025003018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025003019 active site 1211025003020 motif I; other site 1211025003021 motif II; other site 1211025003022 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1211025003023 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1211025003024 active site 1211025003025 catalytic tetrad [active] 1211025003026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025003027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025003028 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1211025003029 putative effector binding pocket; other site 1211025003030 dimerization interface [polypeptide binding]; other site 1211025003031 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1211025003032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025003033 putative substrate translocation pore; other site 1211025003034 hypothetical protein; Provisional; Region: PRK05421 1211025003035 putative catalytic site [active] 1211025003036 putative metal binding site [ion binding]; other site 1211025003037 putative phosphate binding site [ion binding]; other site 1211025003038 putative catalytic site [active] 1211025003039 putative phosphate binding site [ion binding]; other site 1211025003040 putative metal binding site [ion binding]; other site 1211025003041 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1211025003042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025003043 S-adenosylmethionine binding site [chemical binding]; other site 1211025003044 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1211025003045 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1211025003046 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1211025003047 catalytic residue [active] 1211025003048 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1211025003049 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1211025003050 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1211025003051 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1211025003052 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1211025003053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025003054 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1211025003055 RNA/DNA hybrid binding site [nucleotide binding]; other site 1211025003056 active site 1211025003057 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1211025003058 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1211025003059 active site 1211025003060 catalytic site [active] 1211025003061 substrate binding site [chemical binding]; other site 1211025003062 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1211025003063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025003064 DNA-binding site [nucleotide binding]; DNA binding site 1211025003065 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1211025003066 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1211025003067 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025003068 Walker A/P-loop; other site 1211025003069 ATP binding site [chemical binding]; other site 1211025003070 Q-loop/lid; other site 1211025003071 ABC transporter signature motif; other site 1211025003072 Walker B; other site 1211025003073 D-loop; other site 1211025003074 H-loop/switch region; other site 1211025003075 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1211025003076 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1211025003077 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025003078 Walker A/P-loop; other site 1211025003079 ATP binding site [chemical binding]; other site 1211025003080 Q-loop/lid; other site 1211025003081 ABC transporter signature motif; other site 1211025003082 Walker B; other site 1211025003083 D-loop; other site 1211025003084 H-loop/switch region; other site 1211025003085 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1211025003086 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1211025003087 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 1211025003088 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1211025003089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025003090 dimer interface [polypeptide binding]; other site 1211025003091 conserved gate region; other site 1211025003092 putative PBP binding loops; other site 1211025003093 ABC-ATPase subunit interface; other site 1211025003094 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1211025003095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025003096 dimer interface [polypeptide binding]; other site 1211025003097 conserved gate region; other site 1211025003098 ABC-ATPase subunit interface; other site 1211025003099 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1211025003100 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1211025003101 C-N hydrolase family amidase; Provisional; Region: PRK10438 1211025003102 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1211025003103 putative active site [active] 1211025003104 catalytic triad [active] 1211025003105 dimer interface [polypeptide binding]; other site 1211025003106 multimer interface [polypeptide binding]; other site 1211025003107 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1211025003108 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1211025003109 active site 1211025003110 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1211025003111 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1211025003112 dimer interface [polypeptide binding]; other site 1211025003113 active site 1211025003114 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1211025003115 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1211025003116 putative active site [active] 1211025003117 putative dimer interface [polypeptide binding]; other site 1211025003118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1211025003119 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1211025003120 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1211025003121 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1211025003122 E3 interaction surface; other site 1211025003123 lipoyl attachment site [posttranslational modification]; other site 1211025003124 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1211025003125 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1211025003126 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1211025003127 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1211025003128 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1211025003129 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1211025003130 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1211025003131 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1211025003132 FAD binding pocket [chemical binding]; other site 1211025003133 FAD binding motif [chemical binding]; other site 1211025003134 phosphate binding motif [ion binding]; other site 1211025003135 beta-alpha-beta structure motif; other site 1211025003136 NAD binding pocket [chemical binding]; other site 1211025003137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 1211025003138 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1211025003139 active site 1211025003140 DNA polymerase IV; Validated; Region: PRK02406 1211025003141 DNA binding site [nucleotide binding] 1211025003142 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1211025003143 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1211025003144 metal binding site [ion binding]; metal-binding site 1211025003145 dimer interface [polypeptide binding]; other site 1211025003146 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1211025003147 active site 1211025003148 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1211025003149 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1211025003150 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1211025003151 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1211025003152 trimer interface [polypeptide binding]; other site 1211025003153 eyelet of channel; other site 1211025003154 gamma-glutamyl kinase; Provisional; Region: PRK05429 1211025003155 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1211025003156 nucleotide binding site [chemical binding]; other site 1211025003157 homotetrameric interface [polypeptide binding]; other site 1211025003158 putative phosphate binding site [ion binding]; other site 1211025003159 putative allosteric binding site; other site 1211025003160 PUA domain; Region: PUA; pfam01472 1211025003161 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1211025003162 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1211025003163 putative catalytic cysteine [active] 1211025003164 integrase; Provisional; Region: PRK09692 1211025003165 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1211025003166 active site 1211025003167 Int/Topo IB signature motif; other site 1211025003168 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 1211025003169 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 1211025003170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025003171 nucleotide binding region [chemical binding]; other site 1211025003172 ATP-binding site [chemical binding]; other site 1211025003173 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1211025003174 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1211025003175 Ash protein family; Region: Phage_ASH; pfam10554 1211025003176 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 1211025003177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1211025003178 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1211025003179 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1211025003180 active site 1211025003181 metal binding site [ion binding]; metal-binding site 1211025003182 interdomain interaction site; other site 1211025003183 D5 N terminal like; Region: D5_N; smart00885 1211025003184 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1211025003185 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1211025003186 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1211025003187 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1211025003188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025003189 ATP binding site [chemical binding]; other site 1211025003190 putative Mg++ binding site [ion binding]; other site 1211025003191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025003192 nucleotide binding region [chemical binding]; other site 1211025003193 ATP-binding site [chemical binding]; other site 1211025003194 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1211025003195 ligand binding site [chemical binding]; other site 1211025003196 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1211025003197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025003198 Coenzyme A binding pocket [chemical binding]; other site 1211025003199 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1211025003200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025003201 S-adenosylmethionine binding site [chemical binding]; other site 1211025003202 hypothetical protein; Provisional; Region: PRK13687 1211025003203 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025003204 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025003205 metal binding site [ion binding]; metal-binding site 1211025003206 active site 1211025003207 I-site; other site 1211025003208 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025003209 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1211025003210 Major royal jelly protein; Region: MRJP; pfam03022 1211025003211 short chain dehydrogenase; Provisional; Region: PRK06523 1211025003212 classical (c) SDRs; Region: SDR_c; cd05233 1211025003213 NAD(P) binding site [chemical binding]; other site 1211025003214 active site 1211025003215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025003216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025003217 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1211025003218 putative effector binding pocket; other site 1211025003219 dimerization interface [polypeptide binding]; other site 1211025003220 GAF domain; Region: GAF_3; pfam13492 1211025003221 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025003222 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025003223 metal binding site [ion binding]; metal-binding site 1211025003224 active site 1211025003225 I-site; other site 1211025003226 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1211025003227 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1211025003228 S-methylmethionine transporter; Provisional; Region: PRK11387 1211025003229 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1211025003230 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1211025003231 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1211025003232 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025003233 substrate binding pocket [chemical binding]; other site 1211025003234 membrane-bound complex binding site; other site 1211025003235 hinge residues; other site 1211025003236 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1211025003237 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1211025003238 Walker A/P-loop; other site 1211025003239 ATP binding site [chemical binding]; other site 1211025003240 Q-loop/lid; other site 1211025003241 ABC transporter signature motif; other site 1211025003242 Walker B; other site 1211025003243 D-loop; other site 1211025003244 H-loop/switch region; other site 1211025003245 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1211025003246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025003247 dimer interface [polypeptide binding]; other site 1211025003248 conserved gate region; other site 1211025003249 putative PBP binding loops; other site 1211025003250 ABC-ATPase subunit interface; other site 1211025003251 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1211025003252 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1211025003253 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1211025003254 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1211025003255 putative acyl-acceptor binding pocket; other site 1211025003256 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1211025003257 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1211025003258 dimer interface [polypeptide binding]; other site 1211025003259 active site 1211025003260 Schiff base residues; other site 1211025003261 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1211025003262 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1211025003263 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1211025003264 Isochorismatase family; Region: Isochorismatase; pfam00857 1211025003265 catalytic triad [active] 1211025003266 conserved cis-peptide bond; other site 1211025003267 microcin B17 transporter; Reviewed; Region: PRK11098 1211025003268 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1211025003269 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1211025003270 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1211025003271 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1211025003272 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1211025003273 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1211025003274 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1211025003275 drug efflux system protein MdtG; Provisional; Region: PRK09874 1211025003276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025003277 putative substrate translocation pore; other site 1211025003278 anti-RssB factor; Provisional; Region: PRK10244 1211025003279 psiF repeat; Region: PsiF_repeat; pfam07769 1211025003280 psiF repeat; Region: PsiF_repeat; pfam07769 1211025003281 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1211025003282 MASE2 domain; Region: MASE2; pfam05230 1211025003283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025003284 metal binding site [ion binding]; metal-binding site 1211025003285 active site 1211025003286 I-site; other site 1211025003287 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1211025003288 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1211025003289 hypothetical protein; Validated; Region: PRK00124 1211025003290 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1211025003291 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1211025003292 ADP binding site [chemical binding]; other site 1211025003293 magnesium binding site [ion binding]; other site 1211025003294 putative shikimate binding site; other site 1211025003295 hypothetical protein; Provisional; Region: PRK10380 1211025003296 hypothetical protein; Provisional; Region: PRK10481 1211025003297 hypothetical protein; Provisional; Region: PRK10579 1211025003298 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1211025003299 fructokinase; Reviewed; Region: PRK09557 1211025003300 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1211025003301 nucleotide binding site [chemical binding]; other site 1211025003302 exonuclease subunit SbcC; Provisional; Region: PRK10246 1211025003303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025003304 Walker A/P-loop; other site 1211025003305 ATP binding site [chemical binding]; other site 1211025003306 Q-loop/lid; other site 1211025003307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025003308 ABC transporter signature motif; other site 1211025003309 Walker B; other site 1211025003310 D-loop; other site 1211025003311 H-loop/switch region; other site 1211025003312 exonuclease subunit SbcD; Provisional; Region: PRK10966 1211025003313 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1211025003314 active site 1211025003315 metal binding site [ion binding]; metal-binding site 1211025003316 DNA binding site [nucleotide binding] 1211025003317 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1211025003318 transcriptional regulator PhoB; Provisional; Region: PRK10161 1211025003319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025003320 active site 1211025003321 phosphorylation site [posttranslational modification] 1211025003322 intermolecular recognition site; other site 1211025003323 dimerization interface [polypeptide binding]; other site 1211025003324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025003325 DNA binding site [nucleotide binding] 1211025003326 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1211025003327 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1211025003328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025003329 putative active site [active] 1211025003330 heme pocket [chemical binding]; other site 1211025003331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025003332 dimer interface [polypeptide binding]; other site 1211025003333 phosphorylation site [posttranslational modification] 1211025003334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025003335 ATP binding site [chemical binding]; other site 1211025003336 Mg2+ binding site [ion binding]; other site 1211025003337 G-X-G motif; other site 1211025003338 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1211025003339 putative proline-specific permease; Provisional; Region: proY; PRK10580 1211025003340 Spore germination protein; Region: Spore_permease; cl17796 1211025003341 maltodextrin glucosidase; Provisional; Region: PRK10785 1211025003342 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1211025003343 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1211025003344 active site 1211025003345 homodimer interface [polypeptide binding]; other site 1211025003346 catalytic site [active] 1211025003347 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1211025003348 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1211025003349 peroxidase; Provisional; Region: PRK15000 1211025003350 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1211025003351 dimer interface [polypeptide binding]; other site 1211025003352 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1211025003353 catalytic triad [active] 1211025003354 peroxidatic and resolving cysteines [active] 1211025003355 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1211025003356 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1211025003357 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1211025003358 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1211025003359 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1211025003360 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1211025003361 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1211025003362 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1211025003363 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1211025003364 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1211025003365 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1211025003366 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1211025003367 Protein export membrane protein; Region: SecD_SecF; pfam02355 1211025003368 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1211025003369 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1211025003370 Predicted transcriptional regulator [Transcription]; Region: COG2378 1211025003371 HTH domain; Region: HTH_11; pfam08279 1211025003372 WYL domain; Region: WYL; pfam13280 1211025003373 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1211025003374 hypothetical protein; Provisional; Region: PRK11530 1211025003375 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1211025003376 ATP cone domain; Region: ATP-cone; pfam03477 1211025003377 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1211025003378 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1211025003379 catalytic motif [active] 1211025003380 Zn binding site [ion binding]; other site 1211025003381 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1211025003382 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1211025003383 homopentamer interface [polypeptide binding]; other site 1211025003384 active site 1211025003385 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1211025003386 putative RNA binding site [nucleotide binding]; other site 1211025003387 thiamine monophosphate kinase; Provisional; Region: PRK05731 1211025003388 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1211025003389 ATP binding site [chemical binding]; other site 1211025003390 dimerization interface [polypeptide binding]; other site 1211025003391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1211025003392 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1211025003393 active site 1211025003394 catalytic tetrad [active] 1211025003395 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1211025003396 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1211025003397 TPP-binding site; other site 1211025003398 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1211025003399 PYR/PP interface [polypeptide binding]; other site 1211025003400 dimer interface [polypeptide binding]; other site 1211025003401 TPP binding site [chemical binding]; other site 1211025003402 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1211025003403 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1211025003404 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1211025003405 substrate binding pocket [chemical binding]; other site 1211025003406 chain length determination region; other site 1211025003407 substrate-Mg2+ binding site; other site 1211025003408 catalytic residues [active] 1211025003409 aspartate-rich region 1; other site 1211025003410 active site lid residues [active] 1211025003411 aspartate-rich region 2; other site 1211025003412 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1211025003413 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1211025003414 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1211025003415 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1211025003416 Ligand Binding Site [chemical binding]; other site 1211025003417 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1211025003418 active site residue [active] 1211025003419 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1211025003420 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1211025003421 conserved cys residue [active] 1211025003422 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1211025003423 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1211025003424 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1211025003425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1211025003426 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1211025003427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025003428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025003429 putative substrate translocation pore; other site 1211025003430 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1211025003431 UbiA prenyltransferase family; Region: UbiA; pfam01040 1211025003432 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1211025003433 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1211025003434 Subunit I/III interface [polypeptide binding]; other site 1211025003435 Subunit III/IV interface [polypeptide binding]; other site 1211025003436 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1211025003437 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1211025003438 D-pathway; other site 1211025003439 Putative ubiquinol binding site [chemical binding]; other site 1211025003440 Low-spin heme (heme b) binding site [chemical binding]; other site 1211025003441 Putative water exit pathway; other site 1211025003442 Binuclear center (heme o3/CuB) [ion binding]; other site 1211025003443 K-pathway; other site 1211025003444 Putative proton exit pathway; other site 1211025003445 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1211025003446 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1211025003447 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1211025003448 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1211025003449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025003450 putative substrate translocation pore; other site 1211025003451 hypothetical protein; Provisional; Region: PRK11627 1211025003452 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1211025003453 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1211025003454 transcriptional regulator BolA; Provisional; Region: PRK11628 1211025003455 trigger factor; Provisional; Region: tig; PRK01490 1211025003456 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1211025003457 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1211025003458 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1211025003459 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1211025003460 oligomer interface [polypeptide binding]; other site 1211025003461 active site residues [active] 1211025003462 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1211025003463 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1211025003464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025003465 Walker A motif; other site 1211025003466 ATP binding site [chemical binding]; other site 1211025003467 Walker B motif; other site 1211025003468 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1211025003469 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1211025003470 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1211025003471 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1211025003472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025003473 Walker A motif; other site 1211025003474 ATP binding site [chemical binding]; other site 1211025003475 Walker B motif; other site 1211025003476 arginine finger; other site 1211025003477 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1211025003478 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1211025003479 IHF dimer interface [polypeptide binding]; other site 1211025003480 IHF - DNA interface [nucleotide binding]; other site 1211025003481 periplasmic folding chaperone; Provisional; Region: PRK10788 1211025003482 SurA N-terminal domain; Region: SurA_N_3; cl07813 1211025003483 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1211025003484 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1211025003485 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1211025003486 active site 1211025003487 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1211025003488 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1211025003489 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1211025003490 Ligand Binding Site [chemical binding]; other site 1211025003491 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1211025003492 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1211025003493 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1211025003494 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1211025003495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025003496 active site 1211025003497 motif I; other site 1211025003498 motif II; other site 1211025003499 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1211025003500 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1211025003501 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1211025003502 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1211025003503 catalytic residue [active] 1211025003504 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1211025003505 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1211025003506 putative DNA binding site [nucleotide binding]; other site 1211025003507 putative Zn2+ binding site [ion binding]; other site 1211025003508 AsnC family; Region: AsnC_trans_reg; pfam01037 1211025003509 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1211025003510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1211025003511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025003512 Walker A/P-loop; other site 1211025003513 ATP binding site [chemical binding]; other site 1211025003514 Q-loop/lid; other site 1211025003515 ABC transporter signature motif; other site 1211025003516 Walker B; other site 1211025003517 D-loop; other site 1211025003518 H-loop/switch region; other site 1211025003519 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1211025003520 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1211025003521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025003522 Walker A/P-loop; other site 1211025003523 ATP binding site [chemical binding]; other site 1211025003524 Q-loop/lid; other site 1211025003525 ABC transporter signature motif; other site 1211025003526 Walker B; other site 1211025003527 D-loop; other site 1211025003528 H-loop/switch region; other site 1211025003529 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1211025003530 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1211025003531 ammonium transporter; Provisional; Region: PRK10666 1211025003532 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1211025003533 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1211025003534 active site 1211025003535 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1211025003536 catalytic triad [active] 1211025003537 dimer interface [polypeptide binding]; other site 1211025003538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1211025003539 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1211025003540 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1211025003541 DNA binding site [nucleotide binding] 1211025003542 active site 1211025003543 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1211025003544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025003545 DNA-binding site [nucleotide binding]; DNA binding site 1211025003546 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025003547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025003548 homodimer interface [polypeptide binding]; other site 1211025003549 catalytic residue [active] 1211025003550 Predicted membrane protein [Function unknown]; Region: COG2364 1211025003551 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1211025003552 lac repressor; Reviewed; Region: lacI; PRK09526 1211025003553 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025003554 DNA binding site [nucleotide binding] 1211025003555 domain linker motif; other site 1211025003556 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1211025003557 ligand binding site [chemical binding]; other site 1211025003558 dimerization interface (open form) [polypeptide binding]; other site 1211025003559 dimerization interface (closed form) [polypeptide binding]; other site 1211025003560 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1211025003561 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1211025003562 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1211025003563 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1211025003564 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1211025003565 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1211025003566 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1211025003567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025003568 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1211025003569 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1211025003570 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1211025003571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1211025003572 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1211025003573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025003574 DNA-binding site [nucleotide binding]; DNA binding site 1211025003575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025003576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025003577 homodimer interface [polypeptide binding]; other site 1211025003578 catalytic residue [active] 1211025003579 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1211025003580 maltose O-acetyltransferase; Provisional; Region: PRK10092 1211025003581 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1211025003582 active site 1211025003583 substrate binding site [chemical binding]; other site 1211025003584 trimer interface [polypeptide binding]; other site 1211025003585 CoA binding site [chemical binding]; other site 1211025003586 gene expression modulator; Provisional; Region: PRK10945 1211025003587 Hha toxicity attenuator; Provisional; Region: PRK10667 1211025003588 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1211025003589 Protein export membrane protein; Region: SecD_SecF; cl14618 1211025003590 Protein export membrane protein; Region: SecD_SecF; cl14618 1211025003591 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1211025003592 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025003593 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025003594 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1211025003595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025003596 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1211025003597 hypothetical protein; Provisional; Region: PRK11281 1211025003598 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 1211025003599 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1211025003600 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1211025003601 hypothetical protein; Provisional; Region: PRK11038 1211025003602 primosomal replication protein N''; Provisional; Region: PRK10093 1211025003603 hypothetical protein; Provisional; Region: PRK10527 1211025003604 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1211025003605 active site 1211025003606 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1211025003607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025003608 Walker A motif; other site 1211025003609 ATP binding site [chemical binding]; other site 1211025003610 Walker B motif; other site 1211025003611 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1211025003612 arginine finger; other site 1211025003613 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1211025003614 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1211025003615 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1211025003616 hypothetical protein; Validated; Region: PRK00153 1211025003617 recombination protein RecR; Reviewed; Region: recR; PRK00076 1211025003618 RecR protein; Region: RecR; pfam02132 1211025003619 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1211025003620 putative active site [active] 1211025003621 putative metal-binding site [ion binding]; other site 1211025003622 tetramer interface [polypeptide binding]; other site 1211025003623 heat shock protein 90; Provisional; Region: PRK05218 1211025003624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025003625 ATP binding site [chemical binding]; other site 1211025003626 Mg2+ binding site [ion binding]; other site 1211025003627 G-X-G motif; other site 1211025003628 adenylate kinase; Reviewed; Region: adk; PRK00279 1211025003629 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1211025003630 AMP-binding site [chemical binding]; other site 1211025003631 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1211025003632 ferrochelatase; Reviewed; Region: hemH; PRK00035 1211025003633 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1211025003634 C-terminal domain interface [polypeptide binding]; other site 1211025003635 active site 1211025003636 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1211025003637 active site 1211025003638 N-terminal domain interface [polypeptide binding]; other site 1211025003639 inosine/guanosine kinase; Provisional; Region: PRK15074 1211025003640 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1211025003641 putative cation:proton antiport protein; Provisional; Region: PRK10669 1211025003642 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1211025003643 TrkA-N domain; Region: TrkA_N; pfam02254 1211025003644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025003645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025003646 putative substrate translocation pore; other site 1211025003647 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1211025003648 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1211025003649 active site 1211025003650 metal binding site [ion binding]; metal-binding site 1211025003651 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1211025003652 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1211025003653 putative deacylase active site [active] 1211025003654 TraB family; Region: TraB; cl12050 1211025003655 copper exporting ATPase; Provisional; Region: copA; PRK10671 1211025003656 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1211025003657 metal-binding site [ion binding] 1211025003658 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1211025003659 metal-binding site [ion binding] 1211025003660 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1211025003661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025003662 motif II; other site 1211025003663 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1211025003664 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1211025003665 DNA binding residues [nucleotide binding] 1211025003666 dimer interface [polypeptide binding]; other site 1211025003667 copper binding site [ion binding]; other site 1211025003668 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1211025003669 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1211025003670 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1211025003671 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1211025003672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025003673 Walker A/P-loop; other site 1211025003674 ATP binding site [chemical binding]; other site 1211025003675 Q-loop/lid; other site 1211025003676 ABC transporter signature motif; other site 1211025003677 Walker B; other site 1211025003678 D-loop; other site 1211025003679 H-loop/switch region; other site 1211025003680 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1211025003681 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1211025003682 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1211025003683 oxidoreductase; Provisional; Region: PRK08017 1211025003684 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1211025003685 NADP binding site [chemical binding]; other site 1211025003686 active site 1211025003687 steroid binding site; other site 1211025003688 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1211025003689 active site 1211025003690 catalytic triad [active] 1211025003691 oxyanion hole [active] 1211025003692 switch loop; other site 1211025003693 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1211025003694 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1211025003695 Walker A/P-loop; other site 1211025003696 ATP binding site [chemical binding]; other site 1211025003697 Q-loop/lid; other site 1211025003698 ABC transporter signature motif; other site 1211025003699 Walker B; other site 1211025003700 D-loop; other site 1211025003701 H-loop/switch region; other site 1211025003702 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1211025003703 FtsX-like permease family; Region: FtsX; pfam02687 1211025003704 FtsX-like permease family; Region: FtsX; pfam02687 1211025003705 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1211025003706 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1211025003707 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1211025003708 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1211025003709 active site residue [active] 1211025003710 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1211025003711 ATP-grasp domain; Region: ATP-grasp; pfam02222 1211025003712 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1211025003713 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1211025003714 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1211025003715 putative active site [active] 1211025003716 putative metal binding site [ion binding]; other site 1211025003717 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1211025003718 substrate binding site [chemical binding]; other site 1211025003719 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1211025003720 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1211025003721 active site 1211025003722 HIGH motif; other site 1211025003723 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1211025003724 KMSKS motif; other site 1211025003725 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1211025003726 tRNA binding surface [nucleotide binding]; other site 1211025003727 anticodon binding site; other site 1211025003728 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1211025003729 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1211025003730 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025003731 DNA binding site [nucleotide binding] 1211025003732 domain linker motif; other site 1211025003733 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1211025003734 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1211025003735 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1211025003736 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025003737 active site turn [active] 1211025003738 phosphorylation site [posttranslational modification] 1211025003739 ribosome-associated protein; Provisional; Region: PRK11507 1211025003740 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1211025003741 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1211025003742 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1211025003743 homodimer interface [polypeptide binding]; other site 1211025003744 NADP binding site [chemical binding]; other site 1211025003745 substrate binding site [chemical binding]; other site 1211025003746 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1211025003747 fimbrial protein FimI; Provisional; Region: PRK15200 1211025003748 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1211025003749 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025003750 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025003751 outer membrane usher protein FimD; Provisional; Region: PRK15198 1211025003752 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025003753 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025003754 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025003755 Fimbrial protein; Region: Fimbrial; cl01416 1211025003756 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 1211025003757 transcriptional regulator FimZ; Provisional; Region: PRK09935 1211025003758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025003759 active site 1211025003760 phosphorylation site [posttranslational modification] 1211025003761 intermolecular recognition site; other site 1211025003762 dimerization interface [polypeptide binding]; other site 1211025003763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025003764 DNA binding residues [nucleotide binding] 1211025003765 dimerization interface [polypeptide binding]; other site 1211025003766 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1211025003767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025003768 DNA binding residues [nucleotide binding] 1211025003769 dimerization interface [polypeptide binding]; other site 1211025003770 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025003771 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1211025003772 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1211025003773 Ligand binding site; other site 1211025003774 Putative Catalytic site; other site 1211025003775 DXD motif; other site 1211025003776 Predicted membrane protein [Function unknown]; Region: COG2246 1211025003777 GtrA-like protein; Region: GtrA; pfam04138 1211025003778 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1211025003779 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1211025003780 Cytochrome P450; Region: p450; cl12078 1211025003781 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1211025003782 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1211025003783 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1211025003784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025003785 dimer interface [polypeptide binding]; other site 1211025003786 conserved gate region; other site 1211025003787 ABC-ATPase subunit interface; other site 1211025003788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025003789 dimer interface [polypeptide binding]; other site 1211025003790 conserved gate region; other site 1211025003791 putative PBP binding loops; other site 1211025003792 ABC-ATPase subunit interface; other site 1211025003793 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1211025003794 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1211025003795 Walker A/P-loop; other site 1211025003796 ATP binding site [chemical binding]; other site 1211025003797 Q-loop/lid; other site 1211025003798 ABC transporter signature motif; other site 1211025003799 Walker B; other site 1211025003800 D-loop; other site 1211025003801 H-loop/switch region; other site 1211025003802 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1211025003803 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025003804 N-terminal plug; other site 1211025003805 ligand-binding site [chemical binding]; other site 1211025003806 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1211025003807 phenylalanine transporter; Provisional; Region: PRK10249 1211025003808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025003809 non-specific DNA binding site [nucleotide binding]; other site 1211025003810 salt bridge; other site 1211025003811 sequence-specific DNA binding site [nucleotide binding]; other site 1211025003812 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1211025003813 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 1211025003814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1211025003815 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1211025003816 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1211025003817 Metal-binding active site; metal-binding site 1211025003818 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1211025003819 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025003820 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025003821 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1211025003822 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025003823 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025003824 DNA binding site [nucleotide binding] 1211025003825 domain linker motif; other site 1211025003826 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1211025003827 dimerization interface [polypeptide binding]; other site 1211025003828 ligand binding site [chemical binding]; other site 1211025003829 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1211025003830 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1211025003831 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1211025003832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025003833 putative substrate translocation pore; other site 1211025003834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025003835 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1211025003836 sequence-specific DNA binding site [nucleotide binding]; other site 1211025003837 salt bridge; other site 1211025003838 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1211025003839 dimer interface [polypeptide binding]; other site 1211025003840 FMN binding site [chemical binding]; other site 1211025003841 hypothetical protein; Provisional; Region: PRK10250 1211025003842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1211025003843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025003844 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1211025003845 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1211025003846 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1211025003847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025003848 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1211025003849 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1211025003850 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1211025003851 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1211025003852 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1211025003853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025003854 motif II; other site 1211025003855 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1211025003856 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1211025003857 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1211025003858 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025003859 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1211025003860 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1211025003861 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1211025003862 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1211025003863 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1211025003864 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1211025003865 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1211025003866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025003867 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1211025003868 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1211025003869 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1211025003870 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1211025003871 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025003872 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025003873 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1211025003874 PAAR motif; Region: PAAR_motif; pfam05488 1211025003875 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1211025003876 RHS Repeat; Region: RHS_repeat; cl11982 1211025003877 RHS Repeat; Region: RHS_repeat; pfam05593 1211025003878 RHS Repeat; Region: RHS_repeat; cl11982 1211025003879 RHS Repeat; Region: RHS_repeat; pfam05593 1211025003880 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1211025003881 RHS protein; Region: RHS; pfam03527 1211025003882 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1211025003883 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1211025003884 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1211025003885 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1211025003886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025003887 Coenzyme A binding pocket [chemical binding]; other site 1211025003888 potential frameshift: common BLAST hit: gi|296103473|ref|YP_003613619.1| putative DNA-binding protein 1211025003889 Phosphotransferase enzyme family; Region: APH; pfam01636 1211025003890 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1211025003891 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1211025003892 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1211025003893 PYR/PP interface [polypeptide binding]; other site 1211025003894 dimer interface [polypeptide binding]; other site 1211025003895 TPP binding site [chemical binding]; other site 1211025003896 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1211025003897 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1211025003898 TPP-binding site [chemical binding]; other site 1211025003899 dimer interface [polypeptide binding]; other site 1211025003900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025003901 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1211025003902 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1211025003903 dimerization interface [polypeptide binding]; other site 1211025003904 substrate binding pocket [chemical binding]; other site 1211025003905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1211025003906 Transcriptional activator [Transcription]; Region: ChrR; COG3806 1211025003907 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1211025003908 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1211025003909 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1211025003910 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1211025003911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025003912 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1211025003913 dimerization interface [polypeptide binding]; other site 1211025003914 substrate binding pocket [chemical binding]; other site 1211025003915 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1211025003916 classical (c) SDRs; Region: SDR_c; cd05233 1211025003917 NAD(P) binding site [chemical binding]; other site 1211025003918 active site 1211025003919 OsmC-like protein; Region: OsmC; pfam02566 1211025003920 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1211025003921 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1211025003922 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1211025003923 NAD(P) binding site [chemical binding]; other site 1211025003924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025003925 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025003926 putative substrate translocation pore; other site 1211025003927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025003928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025003929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1211025003930 dimerization interface [polypeptide binding]; other site 1211025003931 glutathionine S-transferase; Provisional; Region: PRK10542 1211025003932 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1211025003933 C-terminal domain interface [polypeptide binding]; other site 1211025003934 GSH binding site (G-site) [chemical binding]; other site 1211025003935 dimer interface [polypeptide binding]; other site 1211025003936 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1211025003937 dimer interface [polypeptide binding]; other site 1211025003938 N-terminal domain interface [polypeptide binding]; other site 1211025003939 substrate binding pocket (H-site) [chemical binding]; other site 1211025003940 Helix-turn-helix domain; Region: HTH_18; pfam12833 1211025003941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025003942 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1211025003943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025003944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025003945 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1211025003946 putative dimerization interface [polypeptide binding]; other site 1211025003947 putative substrate binding pocket [chemical binding]; other site 1211025003948 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1211025003949 acetolactate synthase; Reviewed; Region: PRK08617 1211025003950 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1211025003951 PYR/PP interface [polypeptide binding]; other site 1211025003952 dimer interface [polypeptide binding]; other site 1211025003953 TPP binding site [chemical binding]; other site 1211025003954 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1211025003955 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1211025003956 TPP-binding site [chemical binding]; other site 1211025003957 dimer interface [polypeptide binding]; other site 1211025003958 acetoin reductase; Validated; Region: PRK08643 1211025003959 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1211025003960 NAD binding site [chemical binding]; other site 1211025003961 homotetramer interface [polypeptide binding]; other site 1211025003962 homodimer interface [polypeptide binding]; other site 1211025003963 active site 1211025003964 substrate binding site [chemical binding]; other site 1211025003965 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1211025003966 DNA-binding site [nucleotide binding]; DNA binding site 1211025003967 RNA-binding motif; other site 1211025003968 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1211025003969 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025003970 Walker A/P-loop; other site 1211025003971 ATP binding site [chemical binding]; other site 1211025003972 Q-loop/lid; other site 1211025003973 ABC transporter signature motif; other site 1211025003974 Walker B; other site 1211025003975 D-loop; other site 1211025003976 H-loop/switch region; other site 1211025003977 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1211025003978 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025003979 Walker A/P-loop; other site 1211025003980 ATP binding site [chemical binding]; other site 1211025003981 Q-loop/lid; other site 1211025003982 ABC transporter signature motif; other site 1211025003983 Walker B; other site 1211025003984 D-loop; other site 1211025003985 H-loop/switch region; other site 1211025003986 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1211025003987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025003988 dimer interface [polypeptide binding]; other site 1211025003989 conserved gate region; other site 1211025003990 ABC-ATPase subunit interface; other site 1211025003991 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1211025003992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025003993 dimer interface [polypeptide binding]; other site 1211025003994 conserved gate region; other site 1211025003995 putative PBP binding loops; other site 1211025003996 ABC-ATPase subunit interface; other site 1211025003997 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1211025003998 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1211025003999 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1211025004000 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1211025004001 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1211025004002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1211025004003 NAD(P) binding site [chemical binding]; other site 1211025004004 active site 1211025004005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 1211025004006 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1211025004007 RNA polymerase sigma factor; Provisional; Region: PRK11924 1211025004008 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1211025004009 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1211025004010 DNA binding residues [nucleotide binding] 1211025004011 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1211025004012 Fasciclin domain; Region: Fasciclin; pfam02469 1211025004013 choline dehydrogenase; Validated; Region: PRK02106 1211025004014 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1211025004015 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1211025004016 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1211025004017 tetrameric interface [polypeptide binding]; other site 1211025004018 NAD binding site [chemical binding]; other site 1211025004019 catalytic residues [active] 1211025004020 transcriptional regulator BetI; Validated; Region: PRK00767 1211025004021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025004022 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1211025004023 choline transport protein BetT; Provisional; Region: PRK09928 1211025004024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025004025 non-specific DNA binding site [nucleotide binding]; other site 1211025004026 salt bridge; other site 1211025004027 sequence-specific DNA binding site [nucleotide binding]; other site 1211025004028 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1211025004029 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1211025004030 metal binding site [ion binding]; metal-binding site 1211025004031 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1211025004032 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1211025004033 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1211025004034 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025004035 ABC-ATPase subunit interface; other site 1211025004036 dimer interface [polypeptide binding]; other site 1211025004037 putative PBP binding regions; other site 1211025004038 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1211025004039 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025004040 ABC-ATPase subunit interface; other site 1211025004041 dimer interface [polypeptide binding]; other site 1211025004042 putative PBP binding regions; other site 1211025004043 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1211025004044 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1211025004045 outer membrane receptor FepA; Provisional; Region: PRK13524 1211025004046 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025004047 N-terminal plug; other site 1211025004048 ligand-binding site [chemical binding]; other site 1211025004049 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1211025004050 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1211025004051 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1211025004052 MbtH-like protein; Region: MbtH; cl01279 1211025004053 potential frameshift: common BLAST hit: gi|296103453|ref|YP_003613599.1| enterobactin synthase subunit F 1211025004054 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1211025004055 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1211025004056 Walker A/P-loop; other site 1211025004057 ATP binding site [chemical binding]; other site 1211025004058 Q-loop/lid; other site 1211025004059 ABC transporter signature motif; other site 1211025004060 Walker B; other site 1211025004061 D-loop; other site 1211025004062 H-loop/switch region; other site 1211025004063 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1211025004064 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025004065 ABC-ATPase subunit interface; other site 1211025004066 dimer interface [polypeptide binding]; other site 1211025004067 putative PBP binding regions; other site 1211025004068 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1211025004069 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025004070 ABC-ATPase subunit interface; other site 1211025004071 dimer interface [polypeptide binding]; other site 1211025004072 putative PBP binding regions; other site 1211025004073 H+ Antiporter protein; Region: 2A0121; TIGR00900 1211025004074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025004075 putative substrate translocation pore; other site 1211025004076 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1211025004077 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1211025004078 siderophore binding site; other site 1211025004079 isochorismate synthase EntC; Provisional; Region: PRK15016 1211025004080 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1211025004081 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1211025004082 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1211025004083 acyl-activating enzyme (AAE) consensus motif; other site 1211025004084 active site 1211025004085 AMP binding site [chemical binding]; other site 1211025004086 substrate binding site [chemical binding]; other site 1211025004087 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1211025004088 hydrophobic substrate binding pocket; other site 1211025004089 Isochorismatase family; Region: Isochorismatase; pfam00857 1211025004090 active site 1211025004091 conserved cis-peptide bond; other site 1211025004092 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1211025004093 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1211025004094 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1211025004095 putative NAD(P) binding site [chemical binding]; other site 1211025004096 active site 1211025004097 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1211025004098 CoenzymeA binding site [chemical binding]; other site 1211025004099 subunit interaction site [polypeptide binding]; other site 1211025004100 PHB binding site; other site 1211025004101 carbon starvation protein A; Provisional; Region: PRK15015 1211025004102 Carbon starvation protein CstA; Region: CstA; pfam02554 1211025004103 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1211025004104 Uncharacterized small protein [Function unknown]; Region: COG2879 1211025004105 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1211025004106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025004107 salt bridge; other site 1211025004108 non-specific DNA binding site [nucleotide binding]; other site 1211025004109 sequence-specific DNA binding site [nucleotide binding]; other site 1211025004110 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1211025004111 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1211025004112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1211025004113 NAD(P) binding site [chemical binding]; other site 1211025004114 active site 1211025004115 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1211025004116 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1211025004117 putative active site [active] 1211025004118 metal binding site [ion binding]; metal-binding site 1211025004119 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1211025004120 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1211025004121 Walker A/P-loop; other site 1211025004122 ATP binding site [chemical binding]; other site 1211025004123 Q-loop/lid; other site 1211025004124 ABC transporter signature motif; other site 1211025004125 Walker B; other site 1211025004126 D-loop; other site 1211025004127 H-loop/switch region; other site 1211025004128 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1211025004129 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025004130 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025004131 TM-ABC transporter signature motif; other site 1211025004132 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1211025004133 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1211025004134 putative ligand binding site [chemical binding]; other site 1211025004135 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1211025004136 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1211025004137 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1211025004138 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1211025004139 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1211025004140 putative hydrophobic ligand binding site [chemical binding]; other site 1211025004141 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1211025004142 Cupin domain; Region: Cupin_2; cl17218 1211025004143 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1211025004144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025004145 motif II; other site 1211025004146 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1211025004147 intersubunit interface [polypeptide binding]; other site 1211025004148 active site 1211025004149 Zn2+ binding site [ion binding]; other site 1211025004150 methionine aminotransferase; Validated; Region: PRK09082 1211025004151 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025004152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025004153 homodimer interface [polypeptide binding]; other site 1211025004154 catalytic residue [active] 1211025004155 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1211025004156 ParB-like nuclease domain; Region: ParBc; pfam02195 1211025004157 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1211025004158 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1211025004159 Active Sites [active] 1211025004160 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1211025004161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025004162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025004163 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025004164 dimerization interface [polypeptide binding]; other site 1211025004165 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1211025004166 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1211025004167 dimer interface [polypeptide binding]; other site 1211025004168 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1211025004169 catalytic triad [active] 1211025004170 peroxidatic and resolving cysteines [active] 1211025004171 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1211025004172 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1211025004173 catalytic residue [active] 1211025004174 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1211025004175 catalytic residues [active] 1211025004176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1211025004177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025004178 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1211025004179 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1211025004180 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 1211025004181 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1211025004182 putative [4Fe-4S] binding site [ion binding]; other site 1211025004183 putative molybdopterin cofactor binding site [chemical binding]; other site 1211025004184 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1211025004185 molybdopterin cofactor binding site; other site 1211025004186 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1211025004187 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1211025004188 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1211025004189 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1211025004190 Ligand Binding Site [chemical binding]; other site 1211025004191 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1211025004192 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1211025004193 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1211025004194 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1211025004195 B1 nucleotide binding pocket [chemical binding]; other site 1211025004196 B2 nucleotide binding pocket [chemical binding]; other site 1211025004197 CAS motifs; other site 1211025004198 active site 1211025004199 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1211025004200 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1211025004201 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1211025004202 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1211025004203 DNA-binding site [nucleotide binding]; DNA binding site 1211025004204 RNA-binding motif; other site 1211025004205 chromosome condensation membrane protein; Provisional; Region: PRK14196 1211025004206 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1211025004207 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1211025004208 putative active site [active] 1211025004209 catalytic triad [active] 1211025004210 putative dimer interface [polypeptide binding]; other site 1211025004211 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1211025004212 lipoyl synthase; Provisional; Region: PRK05481 1211025004213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025004214 FeS/SAM binding site; other site 1211025004215 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1211025004216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025004217 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1211025004218 substrate binding pocket [chemical binding]; other site 1211025004219 dimerization interface [polypeptide binding]; other site 1211025004220 lipoate-protein ligase B; Provisional; Region: PRK14342 1211025004221 hypothetical protein; Provisional; Region: PRK04998 1211025004222 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1211025004223 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1211025004224 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1211025004225 rare lipoprotein A; Provisional; Region: PRK10672 1211025004226 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1211025004227 cell wall shape-determining protein; Provisional; Region: PRK10794 1211025004228 penicillin-binding protein 2; Provisional; Region: PRK10795 1211025004229 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1211025004230 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1211025004231 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1211025004232 ribosome-associated protein; Provisional; Region: PRK11538 1211025004233 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1211025004234 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1211025004235 active site 1211025004236 (T/H)XGH motif; other site 1211025004237 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1211025004238 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1211025004239 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1211025004240 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1211025004241 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1211025004242 HIGH motif; other site 1211025004243 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1211025004244 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1211025004245 active site 1211025004246 KMSKS motif; other site 1211025004247 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1211025004248 tRNA binding surface [nucleotide binding]; other site 1211025004249 hypothetical protein; Provisional; Region: PRK11032 1211025004250 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 1211025004251 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1211025004252 active site 1211025004253 tetramer interface [polypeptide binding]; other site 1211025004254 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1211025004255 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1211025004256 Walker A/P-loop; other site 1211025004257 ATP binding site [chemical binding]; other site 1211025004258 Q-loop/lid; other site 1211025004259 ABC transporter signature motif; other site 1211025004260 Walker B; other site 1211025004261 D-loop; other site 1211025004262 H-loop/switch region; other site 1211025004263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025004264 dimer interface [polypeptide binding]; other site 1211025004265 conserved gate region; other site 1211025004266 putative PBP binding loops; other site 1211025004267 ABC-ATPase subunit interface; other site 1211025004268 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1211025004269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025004270 dimer interface [polypeptide binding]; other site 1211025004271 conserved gate region; other site 1211025004272 putative PBP binding loops; other site 1211025004273 ABC-ATPase subunit interface; other site 1211025004274 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1211025004275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025004276 substrate binding pocket [chemical binding]; other site 1211025004277 membrane-bound complex binding site; other site 1211025004278 hinge residues; other site 1211025004279 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1211025004280 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1211025004281 putative active site [active] 1211025004282 catalytic triad [active] 1211025004283 putative dimer interface [polypeptide binding]; other site 1211025004284 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1211025004285 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1211025004286 Transporter associated domain; Region: CorC_HlyC; smart01091 1211025004287 metal-binding heat shock protein; Provisional; Region: PRK00016 1211025004288 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1211025004289 PhoH-like protein; Region: PhoH; pfam02562 1211025004290 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1211025004291 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1211025004292 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025004293 FeS/SAM binding site; other site 1211025004294 TRAM domain; Region: TRAM; pfam01938 1211025004295 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1211025004296 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1211025004297 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1211025004298 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1211025004299 active site 1211025004300 dimer interface [polypeptide binding]; other site 1211025004301 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1211025004302 Ligand Binding Site [chemical binding]; other site 1211025004303 Molecular Tunnel; other site 1211025004304 UMP phosphatase; Provisional; Region: PRK10444 1211025004305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025004306 active site 1211025004307 motif I; other site 1211025004308 motif II; other site 1211025004309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025004310 MarR family; Region: MarR; pfam01047 1211025004311 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1211025004312 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1211025004313 nucleotide binding site [chemical binding]; other site 1211025004314 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1211025004315 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1211025004316 active site 1211025004317 dimer interface [polypeptide binding]; other site 1211025004318 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1211025004319 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1211025004320 active site 1211025004321 trimer interface [polypeptide binding]; other site 1211025004322 allosteric site; other site 1211025004323 active site lid [active] 1211025004324 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1211025004325 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1211025004326 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1211025004327 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025004328 active site turn [active] 1211025004329 phosphorylation site [posttranslational modification] 1211025004330 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1211025004331 HPr interaction site; other site 1211025004332 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1211025004333 active site 1211025004334 phosphorylation site [posttranslational modification] 1211025004335 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1211025004336 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1211025004337 active site 1211025004338 HIGH motif; other site 1211025004339 nucleotide binding site [chemical binding]; other site 1211025004340 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1211025004341 KMSKS motif; other site 1211025004342 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1211025004343 outer membrane porin, OprD family; Region: OprD; pfam03573 1211025004344 YbfN-like lipoprotein; Region: YbfN; pfam13982 1211025004345 ferric uptake regulator; Provisional; Region: fur; PRK09462 1211025004346 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1211025004347 metal binding site 2 [ion binding]; metal-binding site 1211025004348 putative DNA binding helix; other site 1211025004349 metal binding site 1 [ion binding]; metal-binding site 1211025004350 dimer interface [polypeptide binding]; other site 1211025004351 structural Zn2+ binding site [ion binding]; other site 1211025004352 flavodoxin FldA; Validated; Region: PRK09267 1211025004353 LexA regulated protein; Provisional; Region: PRK11675 1211025004354 acyl-CoA esterase; Provisional; Region: PRK10673 1211025004355 PGAP1-like protein; Region: PGAP1; pfam07819 1211025004356 replication initiation regulator SeqA; Provisional; Region: PRK11187 1211025004357 phosphoglucomutase; Validated; Region: PRK07564 1211025004358 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1211025004359 active site 1211025004360 substrate binding site [chemical binding]; other site 1211025004361 metal binding site [ion binding]; metal-binding site 1211025004362 putrescine transporter; Provisional; Region: potE; PRK10655 1211025004363 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1211025004364 ornithine decarboxylase; Provisional; Region: PRK13578 1211025004365 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1211025004366 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1211025004367 homodimer interface [polypeptide binding]; other site 1211025004368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025004369 catalytic residue [active] 1211025004370 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1211025004371 Protein of unknown function (DUF2618); Region: DUF2618; pfam10940 1211025004372 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1211025004373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025004374 active site 1211025004375 phosphorylation site [posttranslational modification] 1211025004376 intermolecular recognition site; other site 1211025004377 dimerization interface [polypeptide binding]; other site 1211025004378 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025004379 DNA binding site [nucleotide binding] 1211025004380 sensor protein KdpD; Provisional; Region: PRK10490 1211025004381 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1211025004382 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1211025004383 Ligand Binding Site [chemical binding]; other site 1211025004384 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1211025004385 GAF domain; Region: GAF_3; pfam13492 1211025004386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025004387 dimer interface [polypeptide binding]; other site 1211025004388 phosphorylation site [posttranslational modification] 1211025004389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025004390 ATP binding site [chemical binding]; other site 1211025004391 Mg2+ binding site [ion binding]; other site 1211025004392 G-X-G motif; other site 1211025004393 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1211025004394 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1211025004395 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1211025004396 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1211025004397 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1211025004398 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1211025004399 DNA photolyase; Region: DNA_photolyase; pfam00875 1211025004400 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1211025004401 metal-binding protein; Provisional; Region: PRK10799 1211025004402 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1211025004403 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1211025004404 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1211025004405 LamB/YcsF family protein; Provisional; Region: PRK05406 1211025004406 endonuclease VIII; Provisional; Region: PRK10445 1211025004407 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1211025004408 DNA binding site [nucleotide binding] 1211025004409 catalytic residue [active] 1211025004410 putative catalytic residues [active] 1211025004411 H2TH interface [polypeptide binding]; other site 1211025004412 intercalation triad [nucleotide binding]; other site 1211025004413 substrate specificity determining residue; other site 1211025004414 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1211025004415 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1211025004416 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1211025004417 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1211025004418 dimer interface [polypeptide binding]; other site 1211025004419 active site 1211025004420 citrylCoA binding site [chemical binding]; other site 1211025004421 NADH binding [chemical binding]; other site 1211025004422 cationic pore residues; other site 1211025004423 oxalacetate/citrate binding site [chemical binding]; other site 1211025004424 coenzyme A binding site [chemical binding]; other site 1211025004425 catalytic triad [active] 1211025004426 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1211025004427 Iron-sulfur protein interface; other site 1211025004428 proximal quinone binding site [chemical binding]; other site 1211025004429 SdhD (CybS) interface [polypeptide binding]; other site 1211025004430 proximal heme binding site [chemical binding]; other site 1211025004431 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1211025004432 SdhC subunit interface [polypeptide binding]; other site 1211025004433 proximal heme binding site [chemical binding]; other site 1211025004434 cardiolipin binding site; other site 1211025004435 Iron-sulfur protein interface; other site 1211025004436 proximal quinone binding site [chemical binding]; other site 1211025004437 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1211025004438 L-aspartate oxidase; Provisional; Region: PRK06175 1211025004439 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1211025004440 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1211025004441 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1211025004442 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1211025004443 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1211025004444 TPP-binding site [chemical binding]; other site 1211025004445 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1211025004446 dimer interface [polypeptide binding]; other site 1211025004447 PYR/PP interface [polypeptide binding]; other site 1211025004448 TPP binding site [chemical binding]; other site 1211025004449 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1211025004450 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1211025004451 E3 interaction surface; other site 1211025004452 lipoyl attachment site [posttranslational modification]; other site 1211025004453 e3 binding domain; Region: E3_binding; pfam02817 1211025004454 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1211025004455 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1211025004456 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1211025004457 CoA-ligase; Region: Ligase_CoA; pfam00549 1211025004458 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1211025004459 CoA binding domain; Region: CoA_binding; smart00881 1211025004460 CoA-ligase; Region: Ligase_CoA; pfam00549 1211025004461 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 1211025004462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025004463 DNA-binding site [nucleotide binding]; DNA binding site 1211025004464 UTRA domain; Region: UTRA; pfam07702 1211025004465 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1211025004466 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1211025004467 active site 1211025004468 phosphorylation site [posttranslational modification] 1211025004469 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1211025004470 active site 1211025004471 P-loop; other site 1211025004472 phosphorylation site [posttranslational modification] 1211025004473 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1211025004474 alpha-mannosidase; Provisional; Region: PRK09819 1211025004475 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1211025004476 active site 1211025004477 metal binding site [ion binding]; metal-binding site 1211025004478 catalytic site [active] 1211025004479 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1211025004480 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1211025004481 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1211025004482 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1211025004483 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1211025004484 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1211025004485 hypothetical protein; Provisional; Region: PRK10588 1211025004486 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1211025004487 active site 1211025004488 colicin uptake protein TolQ; Provisional; Region: PRK10801 1211025004489 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1211025004490 colicin uptake protein TolR; Provisional; Region: PRK11024 1211025004491 TolA C-terminal; Region: TolA; pfam06519 1211025004492 translocation protein TolB; Provisional; Region: tolB; PRK03629 1211025004493 TolB amino-terminal domain; Region: TolB_N; pfam04052 1211025004494 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1211025004495 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1211025004496 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1211025004497 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1211025004498 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1211025004499 ligand binding site [chemical binding]; other site 1211025004500 tol-pal system protein YbgF; Provisional; Region: PRK10803 1211025004501 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1211025004502 quinolinate synthetase; Provisional; Region: PRK09375 1211025004503 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1211025004504 zinc transporter ZitB; Provisional; Region: PRK03557 1211025004505 YbgS-like protein; Region: YbgS; pfam13985 1211025004506 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1211025004507 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1211025004508 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1211025004509 catalytic core [active] 1211025004510 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1211025004511 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1211025004512 active site 1211025004513 catalytic residues [active] 1211025004514 galactokinase; Provisional; Region: PRK05101 1211025004515 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1211025004516 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1211025004517 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1211025004518 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1211025004519 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1211025004520 dimer interface [polypeptide binding]; other site 1211025004521 active site 1211025004522 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1211025004523 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1211025004524 NAD binding site [chemical binding]; other site 1211025004525 homodimer interface [polypeptide binding]; other site 1211025004526 active site 1211025004527 substrate binding site [chemical binding]; other site 1211025004528 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1211025004529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025004530 Walker A/P-loop; other site 1211025004531 ATP binding site [chemical binding]; other site 1211025004532 Q-loop/lid; other site 1211025004533 ABC transporter signature motif; other site 1211025004534 Walker B; other site 1211025004535 D-loop; other site 1211025004536 H-loop/switch region; other site 1211025004537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025004538 Walker A/P-loop; other site 1211025004539 ATP binding site [chemical binding]; other site 1211025004540 Q-loop/lid; other site 1211025004541 ABC transporter signature motif; other site 1211025004542 Walker B; other site 1211025004543 D-loop; other site 1211025004544 H-loop/switch region; other site 1211025004545 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1211025004546 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1211025004547 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1211025004548 TOBE domain; Region: TOBE; pfam03459 1211025004549 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1211025004550 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1211025004551 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025004552 substrate binding pocket [chemical binding]; other site 1211025004553 membrane-bound complex binding site; other site 1211025004554 hinge residues; other site 1211025004555 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1211025004556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025004557 putative PBP binding loops; other site 1211025004558 ABC-ATPase subunit interface; other site 1211025004559 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1211025004560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025004561 Walker A/P-loop; other site 1211025004562 ATP binding site [chemical binding]; other site 1211025004563 Q-loop/lid; other site 1211025004564 ABC transporter signature motif; other site 1211025004565 Walker B; other site 1211025004566 D-loop; other site 1211025004567 H-loop/switch region; other site 1211025004568 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1211025004569 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1211025004570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025004571 active site 1211025004572 motif I; other site 1211025004573 motif II; other site 1211025004574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025004575 6-phosphogluconolactonase; Provisional; Region: PRK11028 1211025004576 acyl-CoA thioesterase; Provisional; Region: PRK10531 1211025004577 putative pectinesterase; Region: PLN02432; cl01911 1211025004578 imidazolonepropionase; Validated; Region: PRK09356 1211025004579 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1211025004580 active site 1211025004581 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1211025004582 putative active site [active] 1211025004583 putative metal binding site [ion binding]; other site 1211025004584 histidine utilization repressor; Provisional; Region: PRK14999 1211025004585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025004586 DNA-binding site [nucleotide binding]; DNA binding site 1211025004587 UTRA domain; Region: UTRA; pfam07702 1211025004588 urocanate hydratase; Provisional; Region: PRK05414 1211025004589 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1211025004590 active sites [active] 1211025004591 tetramer interface [polypeptide binding]; other site 1211025004592 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1211025004593 substrate binding site [chemical binding]; other site 1211025004594 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1211025004595 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1211025004596 inhibitor-cofactor binding pocket; inhibition site 1211025004597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025004598 catalytic residue [active] 1211025004599 biotin synthase; Provisional; Region: PRK15108 1211025004600 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025004601 FeS/SAM binding site; other site 1211025004602 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1211025004603 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1211025004604 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1211025004605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1211025004606 catalytic residue [active] 1211025004607 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1211025004608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025004609 S-adenosylmethionine binding site [chemical binding]; other site 1211025004610 AAA domain; Region: AAA_26; pfam13500 1211025004611 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1211025004612 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1211025004613 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1211025004614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025004615 Walker A/P-loop; other site 1211025004616 ATP binding site [chemical binding]; other site 1211025004617 Q-loop/lid; other site 1211025004618 ABC transporter signature motif; other site 1211025004619 Walker B; other site 1211025004620 D-loop; other site 1211025004621 H-loop/switch region; other site 1211025004622 excinuclease ABC subunit B; Provisional; Region: PRK05298 1211025004623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025004624 ATP binding site [chemical binding]; other site 1211025004625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025004626 nucleotide binding region [chemical binding]; other site 1211025004627 ATP-binding site [chemical binding]; other site 1211025004628 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1211025004629 UvrB/uvrC motif; Region: UVR; pfam02151 1211025004630 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1211025004631 phosphate binding site [ion binding]; other site 1211025004632 putative substrate binding pocket [chemical binding]; other site 1211025004633 dimer interface [polypeptide binding]; other site 1211025004634 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1211025004635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025004636 FeS/SAM binding site; other site 1211025004637 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1211025004638 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1211025004639 MPT binding site; other site 1211025004640 trimer interface [polypeptide binding]; other site 1211025004641 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1211025004642 trimer interface [polypeptide binding]; other site 1211025004643 dimer interface [polypeptide binding]; other site 1211025004644 putative active site [active] 1211025004645 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1211025004646 MoaE interaction surface [polypeptide binding]; other site 1211025004647 MoeB interaction surface [polypeptide binding]; other site 1211025004648 thiocarboxylated glycine; other site 1211025004649 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1211025004650 MoaE homodimer interface [polypeptide binding]; other site 1211025004651 MoaD interaction [polypeptide binding]; other site 1211025004652 active site residues [active] 1211025004653 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1211025004654 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1211025004655 Predicted integral membrane protein [Function unknown]; Region: COG0392 1211025004656 cardiolipin synthase 2; Provisional; Region: PRK11263 1211025004657 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1211025004658 putative active site [active] 1211025004659 catalytic site [active] 1211025004660 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1211025004661 putative active site [active] 1211025004662 catalytic site [active] 1211025004663 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1211025004664 putative catalytic site [active] 1211025004665 putative metal binding site [ion binding]; other site 1211025004666 putative phosphate binding site [ion binding]; other site 1211025004667 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1211025004668 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1211025004669 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1211025004670 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1211025004671 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1211025004672 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1211025004673 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1211025004674 Walker A/P-loop; other site 1211025004675 ATP binding site [chemical binding]; other site 1211025004676 Q-loop/lid; other site 1211025004677 ABC transporter signature motif; other site 1211025004678 Walker B; other site 1211025004679 D-loop; other site 1211025004680 H-loop/switch region; other site 1211025004681 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1211025004682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1211025004683 Walker A/P-loop; other site 1211025004684 ATP binding site [chemical binding]; other site 1211025004685 Q-loop/lid; other site 1211025004686 ABC transporter signature motif; other site 1211025004687 Walker B; other site 1211025004688 D-loop; other site 1211025004689 H-loop/switch region; other site 1211025004690 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1211025004691 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025004692 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025004693 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1211025004694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025004695 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1211025004696 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1211025004697 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1211025004698 ATP binding site [chemical binding]; other site 1211025004699 Mg++ binding site [ion binding]; other site 1211025004700 motif III; other site 1211025004701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025004702 nucleotide binding region [chemical binding]; other site 1211025004703 ATP-binding site [chemical binding]; other site 1211025004704 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1211025004705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1211025004706 DEAD_2; Region: DEAD_2; pfam06733 1211025004707 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1211025004708 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1211025004709 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1211025004710 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1211025004711 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025004712 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025004713 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025004714 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025004715 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1211025004716 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025004717 Fimbrial protein; Region: Fimbrial; cl01416 1211025004718 glycosyl transferase family protein; Provisional; Region: PRK08136 1211025004719 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1211025004720 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1211025004721 hypothetical protein; Provisional; Region: PRK11019 1211025004722 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1211025004723 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1211025004724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025004725 S-adenosylmethionine binding site [chemical binding]; other site 1211025004726 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1211025004727 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1211025004728 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1211025004729 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1211025004730 Walker A/P-loop; other site 1211025004731 ATP binding site [chemical binding]; other site 1211025004732 Q-loop/lid; other site 1211025004733 ABC transporter signature motif; other site 1211025004734 Walker B; other site 1211025004735 D-loop; other site 1211025004736 H-loop/switch region; other site 1211025004737 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1211025004738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025004739 dimer interface [polypeptide binding]; other site 1211025004740 conserved gate region; other site 1211025004741 putative PBP binding loops; other site 1211025004742 ABC-ATPase subunit interface; other site 1211025004743 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1211025004744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025004745 substrate binding pocket [chemical binding]; other site 1211025004746 membrane-bound complex binding site; other site 1211025004747 hinge residues; other site 1211025004748 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1211025004749 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1211025004750 dimerization interface [polypeptide binding]; other site 1211025004751 DPS ferroxidase diiron center [ion binding]; other site 1211025004752 ion pore; other site 1211025004753 threonine and homoserine efflux system; Provisional; Region: PRK10532 1211025004754 EamA-like transporter family; Region: EamA; pfam00892 1211025004755 outer membrane protein X; Provisional; Region: ompX; PRK09408 1211025004756 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1211025004757 Sulfatase; Region: Sulfatase; pfam00884 1211025004758 manganese transport regulator MntR; Provisional; Region: PRK11050 1211025004759 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1211025004760 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1211025004761 potential frameshift: common BLAST hit: gi|296103251|ref|YP_003613397.1| citrate transporter 1211025004762 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1211025004763 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025004764 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025004765 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1211025004766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025004767 putative substrate translocation pore; other site 1211025004768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025004769 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1211025004770 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1211025004771 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1211025004772 active site 1211025004773 catalytic tetrad [active] 1211025004774 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1211025004775 beta-galactosidase; Region: BGL; TIGR03356 1211025004776 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1211025004777 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1211025004778 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1211025004779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025004780 DNA-binding site [nucleotide binding]; DNA binding site 1211025004781 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1211025004782 L,D-transpeptidase; Provisional; Region: PRK10260 1211025004783 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1211025004784 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1211025004785 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1211025004786 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025004787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025004788 Walker A/P-loop; other site 1211025004789 ATP binding site [chemical binding]; other site 1211025004790 Q-loop/lid; other site 1211025004791 ABC transporter signature motif; other site 1211025004792 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025004793 Walker B; other site 1211025004794 D-loop; other site 1211025004795 ABC transporter; Region: ABC_tran_2; pfam12848 1211025004796 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025004797 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1211025004798 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1211025004799 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1211025004800 putative active site [active] 1211025004801 putative catalytic site [active] 1211025004802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025004803 D-galactonate transporter; Region: 2A0114; TIGR00893 1211025004804 putative substrate translocation pore; other site 1211025004805 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025004806 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025004807 DNA binding site [nucleotide binding] 1211025004808 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1211025004809 ligand binding site [chemical binding]; other site 1211025004810 dimerization interface [polypeptide binding]; other site 1211025004811 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1211025004812 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1211025004813 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025004814 active site 1211025004815 motif I; other site 1211025004816 motif II; other site 1211025004817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025004818 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1211025004819 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1211025004820 dimer interface [polypeptide binding]; other site 1211025004821 active site 1211025004822 glycine loop; other site 1211025004823 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1211025004824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025004825 FeS/SAM binding site; other site 1211025004826 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1211025004827 active site 1211025004828 intersubunit interactions; other site 1211025004829 catalytic residue [active] 1211025004830 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1211025004831 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1211025004832 ATP binding site [chemical binding]; other site 1211025004833 substrate interface [chemical binding]; other site 1211025004834 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1211025004835 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1211025004836 dimer interface [polypeptide binding]; other site 1211025004837 putative functional site; other site 1211025004838 putative MPT binding site; other site 1211025004839 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1211025004840 catalytic nucleophile [active] 1211025004841 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1211025004842 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025004843 Walker A/P-loop; other site 1211025004844 ATP binding site [chemical binding]; other site 1211025004845 Q-loop/lid; other site 1211025004846 ABC transporter signature motif; other site 1211025004847 Walker B; other site 1211025004848 D-loop; other site 1211025004849 H-loop/switch region; other site 1211025004850 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1211025004851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025004852 Walker A/P-loop; other site 1211025004853 ATP binding site [chemical binding]; other site 1211025004854 Q-loop/lid; other site 1211025004855 ABC transporter signature motif; other site 1211025004856 Walker B; other site 1211025004857 D-loop; other site 1211025004858 H-loop/switch region; other site 1211025004859 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1211025004860 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1211025004861 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1211025004862 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1211025004863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025004864 dimer interface [polypeptide binding]; other site 1211025004865 conserved gate region; other site 1211025004866 putative PBP binding loops; other site 1211025004867 ABC-ATPase subunit interface; other site 1211025004868 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1211025004869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025004870 dimer interface [polypeptide binding]; other site 1211025004871 conserved gate region; other site 1211025004872 putative PBP binding loops; other site 1211025004873 ABC-ATPase subunit interface; other site 1211025004874 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1211025004875 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1211025004876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025004877 FeS/SAM binding site; other site 1211025004878 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1211025004879 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1211025004880 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1211025004881 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1211025004882 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1211025004883 putative C-terminal domain interface [polypeptide binding]; other site 1211025004884 putative GSH binding site (G-site) [chemical binding]; other site 1211025004885 putative dimer interface [polypeptide binding]; other site 1211025004886 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1211025004887 putative N-terminal domain interface [polypeptide binding]; other site 1211025004888 putative dimer interface [polypeptide binding]; other site 1211025004889 putative substrate binding pocket (H-site) [chemical binding]; other site 1211025004890 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1211025004891 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1211025004892 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1211025004893 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1211025004894 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1211025004895 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1211025004896 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1211025004897 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1211025004898 active site 1211025004899 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1211025004900 active site 1211025004901 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1211025004902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025004903 putative substrate translocation pore; other site 1211025004904 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1211025004905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025004906 active site 1211025004907 motif I; other site 1211025004908 motif II; other site 1211025004909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025004910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025004911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025004912 putative substrate translocation pore; other site 1211025004913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1211025004914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025004915 putative transporter; Provisional; Region: PRK04972 1211025004916 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1211025004917 TrkA-C domain; Region: TrkA_C; pfam02080 1211025004918 TrkA-C domain; Region: TrkA_C; pfam02080 1211025004919 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1211025004920 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1211025004921 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1211025004922 GSH binding site [chemical binding]; other site 1211025004923 catalytic residues [active] 1211025004924 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1211025004925 dimer interface [polypeptide binding]; other site 1211025004926 FMN binding site [chemical binding]; other site 1211025004927 NADPH bind site [chemical binding]; other site 1211025004928 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1211025004929 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1211025004930 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1211025004931 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1211025004932 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1211025004933 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1211025004934 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1211025004935 Walker A/P-loop; other site 1211025004936 ATP binding site [chemical binding]; other site 1211025004937 Q-loop/lid; other site 1211025004938 ABC transporter signature motif; other site 1211025004939 Walker B; other site 1211025004940 D-loop; other site 1211025004941 H-loop/switch region; other site 1211025004942 TOBE domain; Region: TOBE_2; pfam08402 1211025004943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025004944 dimer interface [polypeptide binding]; other site 1211025004945 conserved gate region; other site 1211025004946 putative PBP binding loops; other site 1211025004947 ABC-ATPase subunit interface; other site 1211025004948 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1211025004949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025004950 dimer interface [polypeptide binding]; other site 1211025004951 conserved gate region; other site 1211025004952 putative PBP binding loops; other site 1211025004953 ABC-ATPase subunit interface; other site 1211025004954 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1211025004955 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1211025004956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025004957 S-adenosylmethionine binding site [chemical binding]; other site 1211025004958 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1211025004959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025004960 active site 1211025004961 phosphorylation site [posttranslational modification] 1211025004962 intermolecular recognition site; other site 1211025004963 dimerization interface [polypeptide binding]; other site 1211025004964 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025004965 DNA binding site [nucleotide binding] 1211025004966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1211025004967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025004968 dimer interface [polypeptide binding]; other site 1211025004969 phosphorylation site [posttranslational modification] 1211025004970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025004971 ATP binding site [chemical binding]; other site 1211025004972 Mg2+ binding site [ion binding]; other site 1211025004973 G-X-G motif; other site 1211025004974 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1211025004975 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025004976 substrate binding pocket [chemical binding]; other site 1211025004977 membrane-bound complex binding site; other site 1211025004978 hinge residues; other site 1211025004979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025004980 dimer interface [polypeptide binding]; other site 1211025004981 conserved gate region; other site 1211025004982 putative PBP binding loops; other site 1211025004983 ABC-ATPase subunit interface; other site 1211025004984 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1211025004985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025004986 dimer interface [polypeptide binding]; other site 1211025004987 conserved gate region; other site 1211025004988 putative PBP binding loops; other site 1211025004989 ABC-ATPase subunit interface; other site 1211025004990 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1211025004991 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025004992 substrate binding pocket [chemical binding]; other site 1211025004993 membrane-bound complex binding site; other site 1211025004994 hinge residues; other site 1211025004995 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1211025004996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025004997 Walker A/P-loop; other site 1211025004998 ATP binding site [chemical binding]; other site 1211025004999 Q-loop/lid; other site 1211025005000 ABC transporter signature motif; other site 1211025005001 Walker B; other site 1211025005002 D-loop; other site 1211025005003 H-loop/switch region; other site 1211025005004 putative lipoprotein; Provisional; Region: PRK10533 1211025005005 hypothetical protein; Provisional; Region: PRK02877 1211025005006 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1211025005007 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1211025005008 amidase catalytic site [active] 1211025005009 Zn binding residues [ion binding]; other site 1211025005010 substrate binding site [chemical binding]; other site 1211025005011 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1211025005012 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1211025005013 ligand binding site [chemical binding]; other site 1211025005014 flexible hinge region; other site 1211025005015 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1211025005016 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1211025005017 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 1211025005018 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1211025005019 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1211025005020 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1211025005021 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1211025005022 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1211025005023 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1211025005024 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1211025005025 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1211025005026 Walker A motif; other site 1211025005027 ATP binding site [chemical binding]; other site 1211025005028 Walker B motif; other site 1211025005029 type II secretion system protein F; Region: GspF; TIGR02120 1211025005030 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1211025005031 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1211025005032 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1211025005033 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1211025005034 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1211025005035 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1211025005036 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1211025005037 Type II transport protein GspH; Region: GspH; pfam12019 1211025005038 type II secretion system protein I; Region: gspI; TIGR01707 1211025005039 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1211025005040 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1211025005041 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1211025005042 type II secretion system protein J; Region: gspJ; TIGR01711 1211025005043 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1211025005044 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1211025005045 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1211025005046 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1211025005047 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1211025005048 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1211025005049 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1211025005050 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1211025005051 Chitinase A, N-terminal domain; Region: ChitinaseA_N; pfam08329 1211025005052 Glyco_18 domain; Region: Glyco_18; smart00636 1211025005053 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1211025005054 active site 1211025005055 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1211025005056 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1211025005057 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1211025005058 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1211025005059 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1211025005060 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1211025005061 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1211025005062 catalytic residue [active] 1211025005063 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1211025005064 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1211025005065 putative sugar binding site [chemical binding]; other site 1211025005066 catalytic residues [active] 1211025005067 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1211025005068 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1211025005069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1211025005070 NAD(P) binding site [chemical binding]; other site 1211025005071 active site 1211025005072 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1211025005073 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1211025005074 putative NAD(P) binding site [chemical binding]; other site 1211025005075 putative active site [active] 1211025005076 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1211025005077 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1211025005078 tetramer interface [polypeptide binding]; other site 1211025005079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025005080 catalytic residue [active] 1211025005081 pyruvate dehydrogenase; Provisional; Region: PRK09124 1211025005082 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1211025005083 PYR/PP interface [polypeptide binding]; other site 1211025005084 dimer interface [polypeptide binding]; other site 1211025005085 tetramer interface [polypeptide binding]; other site 1211025005086 TPP binding site [chemical binding]; other site 1211025005087 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1211025005088 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1211025005089 TPP-binding site [chemical binding]; other site 1211025005090 Predicted membrane protein [Function unknown]; Region: COG2259 1211025005091 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1211025005092 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1211025005093 FAD binding pocket [chemical binding]; other site 1211025005094 FAD binding motif [chemical binding]; other site 1211025005095 phosphate binding motif [ion binding]; other site 1211025005096 beta-alpha-beta structure motif; other site 1211025005097 NAD binding pocket [chemical binding]; other site 1211025005098 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1211025005099 catalytic loop [active] 1211025005100 iron binding site [ion binding]; other site 1211025005101 hybrid cluster protein; Provisional; Region: PRK05290 1211025005102 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1211025005103 ACS interaction site; other site 1211025005104 CODH interaction site; other site 1211025005105 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1211025005106 hybrid metal cluster; other site 1211025005107 Predicted membrane protein [Function unknown]; Region: COG2431 1211025005108 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1211025005109 amphipathic channel; other site 1211025005110 Asn-Pro-Ala signature motifs; other site 1211025005111 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1211025005112 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1211025005113 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1211025005114 putative active site [active] 1211025005115 putative metal-binding site [ion binding]; other site 1211025005116 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1211025005117 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1211025005118 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025005119 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025005120 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1211025005121 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1211025005122 Walker A/P-loop; other site 1211025005123 ATP binding site [chemical binding]; other site 1211025005124 Q-loop/lid; other site 1211025005125 ABC transporter signature motif; other site 1211025005126 Walker B; other site 1211025005127 D-loop; other site 1211025005128 H-loop/switch region; other site 1211025005129 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1211025005130 FtsX-like permease family; Region: FtsX; pfam02687 1211025005131 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1211025005132 DNA-binding site [nucleotide binding]; DNA binding site 1211025005133 RNA-binding motif; other site 1211025005134 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1211025005135 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1211025005136 Clp amino terminal domain; Region: Clp_N; pfam02861 1211025005137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025005138 Walker A motif; other site 1211025005139 ATP binding site [chemical binding]; other site 1211025005140 Walker B motif; other site 1211025005141 arginine finger; other site 1211025005142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025005143 Walker A motif; other site 1211025005144 ATP binding site [chemical binding]; other site 1211025005145 Walker B motif; other site 1211025005146 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1211025005147 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1211025005148 rRNA binding site [nucleotide binding]; other site 1211025005149 predicted 30S ribosome binding site; other site 1211025005150 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1211025005151 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1211025005152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025005153 Walker A/P-loop; other site 1211025005154 ATP binding site [chemical binding]; other site 1211025005155 Q-loop/lid; other site 1211025005156 ABC transporter signature motif; other site 1211025005157 Walker B; other site 1211025005158 D-loop; other site 1211025005159 H-loop/switch region; other site 1211025005160 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1211025005161 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1211025005162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025005163 Walker A/P-loop; other site 1211025005164 ATP binding site [chemical binding]; other site 1211025005165 Q-loop/lid; other site 1211025005166 ABC transporter signature motif; other site 1211025005167 Walker B; other site 1211025005168 D-loop; other site 1211025005169 H-loop/switch region; other site 1211025005170 thioredoxin reductase; Provisional; Region: PRK10262 1211025005171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1211025005172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025005173 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1211025005174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1211025005175 putative DNA binding site [nucleotide binding]; other site 1211025005176 putative Zn2+ binding site [ion binding]; other site 1211025005177 AsnC family; Region: AsnC_trans_reg; pfam01037 1211025005178 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1211025005179 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1211025005180 DNA translocase FtsK; Provisional; Region: PRK10263 1211025005181 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1211025005182 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1211025005183 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1211025005184 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1211025005185 recombination factor protein RarA; Reviewed; Region: PRK13342 1211025005186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025005187 Walker A motif; other site 1211025005188 ATP binding site [chemical binding]; other site 1211025005189 Walker B motif; other site 1211025005190 arginine finger; other site 1211025005191 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1211025005192 seryl-tRNA synthetase; Provisional; Region: PRK05431 1211025005193 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1211025005194 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1211025005195 dimer interface [polypeptide binding]; other site 1211025005196 active site 1211025005197 motif 1; other site 1211025005198 motif 2; other site 1211025005199 motif 3; other site 1211025005200 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1211025005201 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1211025005202 putative [Fe4-S4] binding site [ion binding]; other site 1211025005203 putative molybdopterin cofactor binding site [chemical binding]; other site 1211025005204 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1211025005205 putative molybdopterin cofactor binding site; other site 1211025005206 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1211025005207 4Fe-4S binding domain; Region: Fer4; pfam00037 1211025005208 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1211025005209 putative MFS family transporter protein; Provisional; Region: PRK03633 1211025005210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025005211 putative substrate translocation pore; other site 1211025005212 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1211025005213 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1211025005214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025005215 FeS/SAM binding site; other site 1211025005216 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1211025005217 Pyruvate formate lyase 1; Region: PFL1; cd01678 1211025005218 coenzyme A binding site [chemical binding]; other site 1211025005219 active site 1211025005220 catalytic residues [active] 1211025005221 glycine loop; other site 1211025005222 formate transporter; Provisional; Region: PRK10805 1211025005223 uncharacterized domain; Region: TIGR00702 1211025005224 YcaO-like family; Region: YcaO; pfam02624 1211025005225 Predicted membrane protein [Function unknown]; Region: COG2323 1211025005226 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1211025005227 homodimer interface [polypeptide binding]; other site 1211025005228 substrate-cofactor binding pocket; other site 1211025005229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025005230 catalytic residue [active] 1211025005231 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1211025005232 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1211025005233 hinge; other site 1211025005234 active site 1211025005235 cytidylate kinase; Provisional; Region: cmk; PRK00023 1211025005236 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1211025005237 CMP-binding site; other site 1211025005238 The sites determining sugar specificity; other site 1211025005239 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1211025005240 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1211025005241 RNA binding site [nucleotide binding]; other site 1211025005242 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1211025005243 RNA binding site [nucleotide binding]; other site 1211025005244 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1211025005245 RNA binding site [nucleotide binding]; other site 1211025005246 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1211025005247 RNA binding site [nucleotide binding]; other site 1211025005248 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1211025005249 RNA binding site [nucleotide binding]; other site 1211025005250 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1211025005251 IHF dimer interface [polypeptide binding]; other site 1211025005252 IHF - DNA interface [nucleotide binding]; other site 1211025005253 ComEC family competence protein; Provisional; Region: PRK11539 1211025005254 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1211025005255 Competence protein; Region: Competence; pfam03772 1211025005256 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1211025005257 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1211025005258 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1211025005259 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1211025005260 Walker A/P-loop; other site 1211025005261 ATP binding site [chemical binding]; other site 1211025005262 Q-loop/lid; other site 1211025005263 ABC transporter signature motif; other site 1211025005264 Walker B; other site 1211025005265 D-loop; other site 1211025005266 H-loop/switch region; other site 1211025005267 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1211025005268 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1211025005269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1211025005270 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1211025005271 Trm112p-like protein; Region: Trm112p; cl01066 1211025005272 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1211025005273 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1211025005274 Ligand binding site; other site 1211025005275 oligomer interface; other site 1211025005276 hypothetical protein; Provisional; Region: PRK10593 1211025005277 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1211025005278 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1211025005279 putative active site [active] 1211025005280 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1211025005281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025005282 S-adenosylmethionine binding site [chemical binding]; other site 1211025005283 condesin subunit F; Provisional; Region: PRK05260 1211025005284 condesin subunit E; Provisional; Region: PRK05256 1211025005285 cell division protein MukB; Provisional; Region: mukB; PRK04863 1211025005286 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1211025005287 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1211025005288 murein L,D-transpeptidase; Provisional; Region: PRK10594 1211025005289 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1211025005290 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1211025005291 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1211025005292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1211025005293 Peptidase M15; Region: Peptidase_M15_3; cl01194 1211025005294 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1211025005295 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1211025005296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025005297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025005298 homodimer interface [polypeptide binding]; other site 1211025005299 catalytic residue [active] 1211025005300 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1211025005301 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1211025005302 trimer interface [polypeptide binding]; other site 1211025005303 eyelet of channel; other site 1211025005304 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1211025005305 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1211025005306 putative dimer interface [polypeptide binding]; other site 1211025005307 putative anticodon binding site; other site 1211025005308 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1211025005309 homodimer interface [polypeptide binding]; other site 1211025005310 motif 1; other site 1211025005311 motif 2; other site 1211025005312 active site 1211025005313 motif 3; other site 1211025005314 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1211025005315 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1211025005316 active site 1211025005317 aminopeptidase N; Provisional; Region: pepN; PRK14015 1211025005318 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1211025005319 active site 1211025005320 Zn binding site [ion binding]; other site 1211025005321 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1211025005322 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1211025005323 Walker A/P-loop; other site 1211025005324 ATP binding site [chemical binding]; other site 1211025005325 Q-loop/lid; other site 1211025005326 ABC transporter signature motif; other site 1211025005327 Walker B; other site 1211025005328 D-loop; other site 1211025005329 H-loop/switch region; other site 1211025005330 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1211025005331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025005332 dimer interface [polypeptide binding]; other site 1211025005333 conserved gate region; other site 1211025005334 putative PBP binding loops; other site 1211025005335 ABC-ATPase subunit interface; other site 1211025005336 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1211025005337 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1211025005338 active site 1211025005339 dimer interface [polypeptide binding]; other site 1211025005340 non-prolyl cis peptide bond; other site 1211025005341 insertion regions; other site 1211025005342 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025005343 substrate binding pocket [chemical binding]; other site 1211025005344 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1211025005345 membrane-bound complex binding site; other site 1211025005346 hinge residues; other site 1211025005347 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1211025005348 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1211025005349 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1211025005350 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1211025005351 quinone interaction residues [chemical binding]; other site 1211025005352 active site 1211025005353 catalytic residues [active] 1211025005354 FMN binding site [chemical binding]; other site 1211025005355 substrate binding site [chemical binding]; other site 1211025005356 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1211025005357 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1211025005358 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1211025005359 MOSC domain; Region: MOSC; pfam03473 1211025005360 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1211025005361 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1211025005362 catalytic loop [active] 1211025005363 iron binding site [ion binding]; other site 1211025005364 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1211025005365 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1211025005366 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1211025005367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025005368 S-adenosylmethionine binding site [chemical binding]; other site 1211025005369 ABC transporter ATPase component; Reviewed; Region: PRK11147 1211025005370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025005371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025005372 Walker A/P-loop; other site 1211025005373 Walker A/P-loop; other site 1211025005374 ATP binding site [chemical binding]; other site 1211025005375 ATP binding site [chemical binding]; other site 1211025005376 Q-loop/lid; other site 1211025005377 Q-loop/lid; other site 1211025005378 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025005379 ABC transporter signature motif; other site 1211025005380 Walker B; other site 1211025005381 D-loop; other site 1211025005382 ABC transporter; Region: ABC_tran_2; pfam12848 1211025005383 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025005384 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1211025005385 Paraquat-inducible protein A; Region: PqiA; pfam04403 1211025005386 Paraquat-inducible protein A; Region: PqiA; pfam04403 1211025005387 paraquat-inducible protein B; Provisional; Region: PRK10807 1211025005388 mce related protein; Region: MCE; pfam02470 1211025005389 mce related protein; Region: MCE; pfam02470 1211025005390 mce related protein; Region: MCE; pfam02470 1211025005391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1211025005392 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1211025005393 Ribosome modulation factor; Region: RMF; pfam04957 1211025005394 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1211025005395 active site 1 [active] 1211025005396 dimer interface [polypeptide binding]; other site 1211025005397 active site 2 [active] 1211025005398 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1211025005399 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1211025005400 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 1211025005401 outer membrane protein A; Reviewed; Region: PRK10808 1211025005402 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1211025005403 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1211025005404 ligand binding site [chemical binding]; other site 1211025005405 SOS cell division inhibitor; Provisional; Region: PRK10595 1211025005406 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1211025005407 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1211025005408 TIGR01666 family membrane protein; Region: YCCS 1211025005409 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1211025005410 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1211025005411 Predicted membrane protein [Function unknown]; Region: COG3304 1211025005412 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1211025005413 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1211025005414 DNA helicase IV; Provisional; Region: helD; PRK11054 1211025005415 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1211025005416 Part of AAA domain; Region: AAA_19; pfam13245 1211025005417 Family description; Region: UvrD_C_2; pfam13538 1211025005418 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1211025005419 active site 1211025005420 dimer interfaces [polypeptide binding]; other site 1211025005421 catalytic residues [active] 1211025005422 hypothetical protein; Provisional; Region: PRK03641 1211025005423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1211025005424 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1211025005425 heat shock protein HspQ; Provisional; Region: PRK14129 1211025005426 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1211025005427 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1211025005428 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1211025005429 putative RNA binding site [nucleotide binding]; other site 1211025005430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025005431 S-adenosylmethionine binding site [chemical binding]; other site 1211025005432 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1211025005433 substrate binding site [chemical binding]; other site 1211025005434 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1211025005435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025005436 acylphosphatase; Provisional; Region: PRK14426 1211025005437 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1211025005438 sulfur transfer protein TusE; Provisional; Region: PRK11508 1211025005439 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1211025005440 YccA-like proteins; Region: YccA_like; cd10433 1211025005441 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1211025005442 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1211025005443 peptide binding site [polypeptide binding]; other site 1211025005444 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1211025005445 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1211025005446 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1211025005447 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1211025005448 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1211025005449 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1211025005450 acyl-activating enzyme (AAE) consensus motif; other site 1211025005451 AMP binding site [chemical binding]; other site 1211025005452 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1211025005453 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1211025005454 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1211025005455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025005456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1211025005457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025005458 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1211025005459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025005460 galactoside permease; Reviewed; Region: lacY; PRK09528 1211025005461 putative substrate translocation pore; other site 1211025005462 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1211025005463 DJ-1 family protein; Region: not_thiJ; TIGR01383 1211025005464 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1211025005465 conserved cys residue [active] 1211025005466 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1211025005467 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1211025005468 FMN-binding pocket [chemical binding]; other site 1211025005469 flavin binding motif; other site 1211025005470 phosphate binding motif [ion binding]; other site 1211025005471 beta-alpha-beta structure motif; other site 1211025005472 NAD binding pocket [chemical binding]; other site 1211025005473 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1211025005474 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1211025005475 catalytic loop [active] 1211025005476 iron binding site [ion binding]; other site 1211025005477 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1211025005478 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1211025005479 [2Fe-2S] cluster binding site [ion binding]; other site 1211025005480 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1211025005481 hydrophobic ligand binding site; other site 1211025005482 FAD binding domain; Region: FAD_binding_3; pfam01494 1211025005483 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1211025005484 OHCU decarboxylase; Region: UraD_2; TIGR03180 1211025005485 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1211025005486 active site 1211025005487 homotetramer interface [polypeptide binding]; other site 1211025005488 guanine deaminase; Provisional; Region: PRK09228 1211025005489 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1211025005490 active site 1211025005491 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1211025005492 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1211025005493 Na binding site [ion binding]; other site 1211025005494 putative substrate binding site [chemical binding]; other site 1211025005495 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1211025005496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025005497 DNA-binding site [nucleotide binding]; DNA binding site 1211025005498 FCD domain; Region: FCD; pfam07729 1211025005499 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1211025005500 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1211025005501 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1211025005502 active site 1211025005503 catalytic site [active] 1211025005504 tetramer interface [polypeptide binding]; other site 1211025005505 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1211025005506 amidase; Provisional; Region: PRK09201 1211025005507 Amidase; Region: Amidase; pfam01425 1211025005508 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1211025005509 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1211025005510 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1211025005511 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1211025005512 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1211025005513 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1211025005514 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1211025005515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025005516 substrate binding pocket [chemical binding]; other site 1211025005517 membrane-bound complex binding site; other site 1211025005518 hinge residues; other site 1211025005519 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1211025005520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025005521 dimer interface [polypeptide binding]; other site 1211025005522 conserved gate region; other site 1211025005523 putative PBP binding loops; other site 1211025005524 ABC-ATPase subunit interface; other site 1211025005525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025005526 dimer interface [polypeptide binding]; other site 1211025005527 conserved gate region; other site 1211025005528 putative PBP binding loops; other site 1211025005529 ABC-ATPase subunit interface; other site 1211025005530 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1211025005531 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1211025005532 Walker A/P-loop; other site 1211025005533 ATP binding site [chemical binding]; other site 1211025005534 Q-loop/lid; other site 1211025005535 ABC transporter signature motif; other site 1211025005536 Walker B; other site 1211025005537 D-loop; other site 1211025005538 H-loop/switch region; other site 1211025005539 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1211025005540 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1211025005541 catalytic residue [active] 1211025005542 potential frameshift: common BLAST hit: gi|296102995|ref|YP_003613141.1| N-carbamoyl-L-amino acid hydrolase 1211025005543 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1211025005544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1211025005545 Divalent cation transporter; Region: MgtE; pfam01769 1211025005546 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1211025005547 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1211025005548 potential frameshift: common BLAST hit: gi|296102979|ref|YP_003613125.1| acid glucose-1-phosphate phosphatase 1211025005549 hypothetical protein; Provisional; Region: PRK10174 1211025005550 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1211025005551 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1211025005552 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1211025005553 EamA-like transporter family; Region: EamA; pfam00892 1211025005554 EamA-like transporter family; Region: EamA; pfam00892 1211025005555 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1211025005556 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1211025005557 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1211025005558 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1211025005559 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1211025005560 putative FMN binding site [chemical binding]; other site 1211025005561 pyrimidine utilization protein D; Region: RutD; TIGR03611 1211025005562 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1211025005563 homotrimer interaction site [polypeptide binding]; other site 1211025005564 putative active site [active] 1211025005565 Isochorismatase family; Region: Isochorismatase; pfam00857 1211025005566 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1211025005567 catalytic triad [active] 1211025005568 conserved cis-peptide bond; other site 1211025005569 pyrimidine utilization protein A; Region: RutA; TIGR03612 1211025005570 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1211025005571 active site 1211025005572 dimer interface [polypeptide binding]; other site 1211025005573 non-prolyl cis peptide bond; other site 1211025005574 insertion regions; other site 1211025005575 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1211025005576 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1211025005577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025005578 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1211025005579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1211025005580 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1211025005581 Predicted transcriptional regulator [Transcription]; Region: COG3905 1211025005582 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1211025005583 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1211025005584 Glutamate binding site [chemical binding]; other site 1211025005585 NAD binding site [chemical binding]; other site 1211025005586 catalytic residues [active] 1211025005587 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1211025005588 Na binding site [ion binding]; other site 1211025005589 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1211025005590 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1211025005591 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1211025005592 Nucleoside recognition; Region: Gate; pfam07670 1211025005593 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1211025005594 FTR1 family protein; Region: TIGR00145 1211025005595 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1211025005596 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1211025005597 Imelysin; Region: Peptidase_M75; pfam09375 1211025005598 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1211025005599 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1211025005600 hypothetical protein; Provisional; Region: PRK10536 1211025005601 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1211025005602 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1211025005603 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1211025005604 Isochorismatase family; Region: Isochorismatase; pfam00857 1211025005605 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1211025005606 catalytic triad [active] 1211025005607 dimer interface [polypeptide binding]; other site 1211025005608 conserved cis-peptide bond; other site 1211025005609 Pirin-related protein [General function prediction only]; Region: COG1741 1211025005610 Pirin; Region: Pirin; pfam02678 1211025005611 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1211025005612 LysR family transcriptional regulator; Provisional; Region: PRK14997 1211025005613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025005614 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1211025005615 putative effector binding pocket; other site 1211025005616 putative dimerization interface [polypeptide binding]; other site 1211025005617 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1211025005618 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1211025005619 putative ligand binding site [chemical binding]; other site 1211025005620 NAD binding site [chemical binding]; other site 1211025005621 dimerization interface [polypeptide binding]; other site 1211025005622 catalytic site [active] 1211025005623 putative hydrolase; Validated; Region: PRK09248 1211025005624 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1211025005625 active site 1211025005626 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1211025005627 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1211025005628 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1211025005629 curli assembly protein CsgF; Provisional; Region: PRK10050 1211025005630 curli assembly protein CsgE; Provisional; Region: PRK10386 1211025005631 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1211025005632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025005633 DNA binding residues [nucleotide binding] 1211025005634 dimerization interface [polypeptide binding]; other site 1211025005635 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1211025005636 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1211025005637 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1211025005638 major curlin subunit; Provisional; Region: csgA; PRK10051 1211025005639 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 1211025005640 Fimbrial protein; Region: Fimbrial; cl01416 1211025005641 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1211025005642 putative ADP-ribose binding site [chemical binding]; other site 1211025005643 putative active site [active] 1211025005644 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1211025005645 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1211025005646 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1211025005647 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1211025005648 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1211025005649 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1211025005650 Ligand binding site; other site 1211025005651 DXD motif; other site 1211025005652 lipoprotein; Provisional; Region: PRK10175 1211025005653 secY/secA suppressor protein; Provisional; Region: PRK11467 1211025005654 drug efflux system protein MdtG; Provisional; Region: PRK09874 1211025005655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025005656 putative substrate translocation pore; other site 1211025005657 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1211025005658 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1211025005659 putative acyl-acceptor binding pocket; other site 1211025005660 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1211025005661 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1211025005662 active site residue [active] 1211025005663 hypothetical protein; Provisional; Region: PRK03757 1211025005664 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1211025005665 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 1211025005666 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1211025005667 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1211025005668 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1211025005669 DNA damage-inducible protein I; Provisional; Region: PRK10597 1211025005670 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1211025005671 active site 1211025005672 substrate binding pocket [chemical binding]; other site 1211025005673 dimer interface [polypeptide binding]; other site 1211025005674 lipoprotein; Provisional; Region: PRK10598 1211025005675 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1211025005676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025005677 putative substrate translocation pore; other site 1211025005678 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1211025005679 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1211025005680 hypothetical protein; Provisional; Region: PRK11239 1211025005681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1211025005682 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025005683 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025005684 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1211025005685 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1211025005686 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1211025005687 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1211025005688 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1211025005689 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1211025005690 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1211025005691 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1211025005692 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1211025005693 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1211025005694 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1211025005695 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1211025005696 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1211025005697 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1211025005698 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1211025005699 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1211025005700 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1211025005701 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1211025005702 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1211025005703 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1211025005704 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1211025005705 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1211025005706 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1211025005707 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1211025005708 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1211025005709 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1211025005710 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1211025005711 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1211025005712 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1211025005713 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1211025005714 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1211025005715 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1211025005716 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1211025005717 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1211025005718 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1211025005719 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1211025005720 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1211025005721 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1211025005722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025005723 putative substrate translocation pore; other site 1211025005724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025005725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025005726 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1211025005727 putative effector binding pocket; other site 1211025005728 dimerization interface [polypeptide binding]; other site 1211025005729 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1211025005730 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1211025005731 homodimer interface [polypeptide binding]; other site 1211025005732 oligonucleotide binding site [chemical binding]; other site 1211025005733 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1211025005734 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1211025005735 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1211025005736 RNA binding surface [nucleotide binding]; other site 1211025005737 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1211025005738 active site 1211025005739 Maf-like protein; Region: Maf; pfam02545 1211025005740 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1211025005741 active site 1211025005742 dimer interface [polypeptide binding]; other site 1211025005743 hypothetical protein; Provisional; Region: PRK11193 1211025005744 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1211025005745 putative phosphate acyltransferase; Provisional; Region: PRK05331 1211025005746 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1211025005747 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1211025005748 dimer interface [polypeptide binding]; other site 1211025005749 active site 1211025005750 CoA binding pocket [chemical binding]; other site 1211025005751 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1211025005752 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1211025005753 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1211025005754 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1211025005755 NAD(P) binding site [chemical binding]; other site 1211025005756 homotetramer interface [polypeptide binding]; other site 1211025005757 homodimer interface [polypeptide binding]; other site 1211025005758 active site 1211025005759 acyl carrier protein; Provisional; Region: acpP; PRK00982 1211025005760 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1211025005761 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1211025005762 dimer interface [polypeptide binding]; other site 1211025005763 active site 1211025005764 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1211025005765 Fimbrial protein; Region: Fimbrial; pfam00419 1211025005766 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1211025005767 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025005768 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025005769 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025005770 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1211025005771 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025005772 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025005773 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1211025005774 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1211025005775 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1211025005776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025005777 catalytic residue [active] 1211025005778 conserved hypothetical protein, YceG family; Region: TIGR00247 1211025005779 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1211025005780 dimerization interface [polypeptide binding]; other site 1211025005781 thymidylate kinase; Validated; Region: tmk; PRK00698 1211025005782 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1211025005783 TMP-binding site; other site 1211025005784 ATP-binding site [chemical binding]; other site 1211025005785 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1211025005786 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1211025005787 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1211025005788 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1211025005789 active site 1211025005790 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1211025005791 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1211025005792 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025005793 active site turn [active] 1211025005794 phosphorylation site [posttranslational modification] 1211025005795 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1211025005796 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025005797 N-terminal plug; other site 1211025005798 ligand-binding site [chemical binding]; other site 1211025005799 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1211025005800 nucleotide binding site/active site [active] 1211025005801 HIT family signature motif; other site 1211025005802 catalytic residue [active] 1211025005803 putative dimer interface [polypeptide binding]; other site 1211025005804 Putative periplasmic lipoprotein; Region: DUF1425; cl12345 1211025005805 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1211025005806 thiamine kinase; Region: ycfN_thiK; TIGR02721 1211025005807 thiamine kinase; Provisional; Region: thiK; PRK10271 1211025005808 substrate binding site [chemical binding]; other site 1211025005809 beta-hexosaminidase; Provisional; Region: PRK05337 1211025005810 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1211025005811 hypothetical protein; Provisional; Region: PRK04940 1211025005812 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1211025005813 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025005814 hypothetical protein; Provisional; Region: PRK11280 1211025005815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1211025005816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025005817 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1211025005818 L,D-transpeptidase; Provisional; Region: PRK10190 1211025005819 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1211025005820 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1211025005821 transcription-repair coupling factor; Provisional; Region: PRK10689 1211025005822 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1211025005823 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025005824 ATP binding site [chemical binding]; other site 1211025005825 putative Mg++ binding site [ion binding]; other site 1211025005826 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025005827 nucleotide binding region [chemical binding]; other site 1211025005828 ATP-binding site [chemical binding]; other site 1211025005829 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1211025005830 Predicted membrane protein [Function unknown]; Region: COG4763 1211025005831 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1211025005832 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1211025005833 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1211025005834 FtsX-like permease family; Region: FtsX; pfam02687 1211025005835 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1211025005836 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1211025005837 Walker A/P-loop; other site 1211025005838 ATP binding site [chemical binding]; other site 1211025005839 Q-loop/lid; other site 1211025005840 ABC transporter signature motif; other site 1211025005841 Walker B; other site 1211025005842 D-loop; other site 1211025005843 H-loop/switch region; other site 1211025005844 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1211025005845 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1211025005846 FtsX-like permease family; Region: FtsX; pfam02687 1211025005847 fructokinase; Reviewed; Region: PRK09557 1211025005848 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1211025005849 nucleotide binding site [chemical binding]; other site 1211025005850 NAD-dependent deacetylase; Provisional; Region: PRK00481 1211025005851 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1211025005852 NAD+ binding site [chemical binding]; other site 1211025005853 substrate binding site [chemical binding]; other site 1211025005854 Zn binding site [ion binding]; other site 1211025005855 Cache domain; Region: Cache_1; pfam02743 1211025005856 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1211025005857 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025005858 dimer interface [polypeptide binding]; other site 1211025005859 putative CheW interface [polypeptide binding]; other site 1211025005860 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1211025005861 EAL domain; Region: EAL; pfam00563 1211025005862 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1211025005863 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1211025005864 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1211025005865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025005866 dimer interface [polypeptide binding]; other site 1211025005867 conserved gate region; other site 1211025005868 putative PBP binding loops; other site 1211025005869 ABC-ATPase subunit interface; other site 1211025005870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025005871 dimer interface [polypeptide binding]; other site 1211025005872 conserved gate region; other site 1211025005873 putative PBP binding loops; other site 1211025005874 ABC-ATPase subunit interface; other site 1211025005875 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1211025005876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025005877 Walker A/P-loop; other site 1211025005878 ATP binding site [chemical binding]; other site 1211025005879 Q-loop/lid; other site 1211025005880 ABC transporter signature motif; other site 1211025005881 Walker B; other site 1211025005882 D-loop; other site 1211025005883 H-loop/switch region; other site 1211025005884 TOBE domain; Region: TOBE_2; pfam08402 1211025005885 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1211025005886 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1211025005887 metal binding site [ion binding]; metal-binding site 1211025005888 dimer interface [polypeptide binding]; other site 1211025005889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1211025005890 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1211025005891 sensor protein PhoQ; Provisional; Region: PRK10815 1211025005892 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1211025005893 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1211025005894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025005895 ATP binding site [chemical binding]; other site 1211025005896 Mg2+ binding site [ion binding]; other site 1211025005897 G-X-G motif; other site 1211025005898 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1211025005899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025005900 active site 1211025005901 phosphorylation site [posttranslational modification] 1211025005902 intermolecular recognition site; other site 1211025005903 dimerization interface [polypeptide binding]; other site 1211025005904 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025005905 DNA binding site [nucleotide binding] 1211025005906 adenylosuccinate lyase; Provisional; Region: PRK09285 1211025005907 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1211025005908 tetramer interface [polypeptide binding]; other site 1211025005909 active site 1211025005910 putative lysogenization regulator; Reviewed; Region: PRK00218 1211025005911 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1211025005912 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1211025005913 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1211025005914 nudix motif; other site 1211025005915 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1211025005916 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1211025005917 probable active site [active] 1211025005918 isocitrate dehydrogenase; Validated; Region: PRK07362 1211025005919 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1211025005920 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1211025005921 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1211025005922 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1211025005923 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1211025005924 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025005925 Cache domain; Region: Cache_1; pfam02743 1211025005926 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025005927 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025005928 metal binding site [ion binding]; metal-binding site 1211025005929 active site 1211025005930 I-site; other site 1211025005931 hypothetical protein; Provisional; Region: PRK10457 1211025005932 GAF domain; Region: GAF; pfam01590 1211025005933 GAF domain; Region: GAF_2; pfam13185 1211025005934 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025005935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025005936 metal binding site [ion binding]; metal-binding site 1211025005937 active site 1211025005938 I-site; other site 1211025005939 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1211025005940 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1211025005941 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1211025005942 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1211025005943 hypothetical protein; Validated; Region: PRK06186 1211025005944 conserved cys residue [active] 1211025005945 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1211025005946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025005947 putative substrate translocation pore; other site 1211025005948 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1211025005949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025005950 Predicted membrane protein [Function unknown]; Region: COG2707 1211025005951 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1211025005952 putative deacylase active site [active] 1211025005953 hypothetical protein; Provisional; Region: PRK05325 1211025005954 PrkA family serine protein kinase; Provisional; Region: PRK15455 1211025005955 AAA ATPase domain; Region: AAA_16; pfam13191 1211025005956 Walker A motif; other site 1211025005957 ATP binding site [chemical binding]; other site 1211025005958 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1211025005959 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1211025005960 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1211025005961 active site 1211025005962 phosphate binding residues; other site 1211025005963 catalytic residues [active] 1211025005964 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1211025005965 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1211025005966 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1211025005967 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1211025005968 SelR domain; Region: SelR; pfam01641 1211025005969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1211025005970 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1211025005971 Glyco_18 domain; Region: Glyco_18; smart00636 1211025005972 active site 1211025005973 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1211025005974 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1211025005975 Isochorismatase family; Region: Isochorismatase; pfam00857 1211025005976 catalytic triad [active] 1211025005977 metal binding site [ion binding]; metal-binding site 1211025005978 conserved cis-peptide bond; other site 1211025005979 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1211025005980 active site 1211025005981 homodimer interface [polypeptide binding]; other site 1211025005982 protease 4; Provisional; Region: PRK10949 1211025005983 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1211025005984 tandem repeat interface [polypeptide binding]; other site 1211025005985 oligomer interface [polypeptide binding]; other site 1211025005986 active site residues [active] 1211025005987 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1211025005988 tandem repeat interface [polypeptide binding]; other site 1211025005989 oligomer interface [polypeptide binding]; other site 1211025005990 active site residues [active] 1211025005991 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1211025005992 putative FMN binding site [chemical binding]; other site 1211025005993 selenophosphate synthetase; Provisional; Region: PRK00943 1211025005994 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1211025005995 dimerization interface [polypeptide binding]; other site 1211025005996 putative ATP binding site [chemical binding]; other site 1211025005997 DNA topoisomerase III; Provisional; Region: PRK07726 1211025005998 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1211025005999 active site 1211025006000 putative interdomain interaction site [polypeptide binding]; other site 1211025006001 putative metal-binding site [ion binding]; other site 1211025006002 putative nucleotide binding site [chemical binding]; other site 1211025006003 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1211025006004 domain I; other site 1211025006005 DNA binding groove [nucleotide binding] 1211025006006 phosphate binding site [ion binding]; other site 1211025006007 domain II; other site 1211025006008 domain III; other site 1211025006009 nucleotide binding site [chemical binding]; other site 1211025006010 catalytic site [active] 1211025006011 domain IV; other site 1211025006012 glutamate dehydrogenase; Provisional; Region: PRK09414 1211025006013 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1211025006014 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1211025006015 NAD(P) binding site [chemical binding]; other site 1211025006016 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1211025006017 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1211025006018 active site 1211025006019 8-oxo-dGMP binding site [chemical binding]; other site 1211025006020 nudix motif; other site 1211025006021 metal binding site [ion binding]; metal-binding site 1211025006022 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1211025006023 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1211025006024 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1211025006025 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1211025006026 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1211025006027 active site residue [active] 1211025006028 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1211025006029 active site residue [active] 1211025006030 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1211025006031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025006032 Walker A/P-loop; other site 1211025006033 ATP binding site [chemical binding]; other site 1211025006034 Q-loop/lid; other site 1211025006035 ABC transporter signature motif; other site 1211025006036 Walker B; other site 1211025006037 D-loop; other site 1211025006038 H-loop/switch region; other site 1211025006039 potential frameshift: common BLAST hit: gi|365970074|ref|YP_004951635.1| inner membrane ABC transporter permease protein ynjC 1211025006040 hypothetical protein; Provisional; Region: PRK11622 1211025006041 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1211025006042 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1211025006043 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1211025006044 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1211025006045 putative catalytic site [active] 1211025006046 putative phosphate binding site [ion binding]; other site 1211025006047 active site 1211025006048 metal binding site A [ion binding]; metal-binding site 1211025006049 DNA binding site [nucleotide binding] 1211025006050 putative AP binding site [nucleotide binding]; other site 1211025006051 putative metal binding site B [ion binding]; other site 1211025006052 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1211025006053 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1211025006054 inhibitor-cofactor binding pocket; inhibition site 1211025006055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025006056 catalytic residue [active] 1211025006057 arginine succinyltransferase; Provisional; Region: PRK10456 1211025006058 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1211025006059 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1211025006060 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1211025006061 NAD(P) binding site [chemical binding]; other site 1211025006062 catalytic residues [active] 1211025006063 succinylarginine dihydrolase; Provisional; Region: PRK13281 1211025006064 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1211025006065 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1211025006066 putative active site [active] 1211025006067 Zn binding site [ion binding]; other site 1211025006068 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1211025006069 dimer interface [polypeptide binding]; other site 1211025006070 hypothetical protein; Provisional; Region: PRK11396 1211025006071 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1211025006072 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1211025006073 GIY-YIG motif/motif A; other site 1211025006074 active site 1211025006075 catalytic site [active] 1211025006076 putative DNA binding site [nucleotide binding]; other site 1211025006077 metal binding site [ion binding]; metal-binding site 1211025006078 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1211025006079 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1211025006080 homodimer interface [polypeptide binding]; other site 1211025006081 NAD binding pocket [chemical binding]; other site 1211025006082 ATP binding pocket [chemical binding]; other site 1211025006083 Mg binding site [ion binding]; other site 1211025006084 active-site loop [active] 1211025006085 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1211025006086 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1211025006087 active site 1211025006088 P-loop; other site 1211025006089 phosphorylation site [posttranslational modification] 1211025006090 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1211025006091 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1211025006092 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1211025006093 methionine cluster; other site 1211025006094 active site 1211025006095 phosphorylation site [posttranslational modification] 1211025006096 metal binding site [ion binding]; metal-binding site 1211025006097 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1211025006098 Cupin domain; Region: Cupin_2; pfam07883 1211025006099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025006100 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1211025006101 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1211025006102 NAD binding site [chemical binding]; other site 1211025006103 sugar binding site [chemical binding]; other site 1211025006104 divalent metal binding site [ion binding]; other site 1211025006105 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1211025006106 dimer interface [polypeptide binding]; other site 1211025006107 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1211025006108 putative active site [active] 1211025006109 YdjC motif; other site 1211025006110 Mg binding site [ion binding]; other site 1211025006111 putative homodimer interface [polypeptide binding]; other site 1211025006112 hydroperoxidase II; Provisional; Region: katE; PRK11249 1211025006113 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1211025006114 tetramer interface [polypeptide binding]; other site 1211025006115 heme binding pocket [chemical binding]; other site 1211025006116 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1211025006117 domain interactions; other site 1211025006118 cell division modulator; Provisional; Region: PRK10113 1211025006119 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1211025006120 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1211025006121 inner membrane protein; Provisional; Region: PRK11648 1211025006122 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1211025006123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025006124 active site 1211025006125 motif I; other site 1211025006126 motif II; other site 1211025006127 YniB-like protein; Region: YniB; pfam14002 1211025006128 Phosphotransferase enzyme family; Region: APH; pfam01636 1211025006129 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1211025006130 active site 1211025006131 ATP binding site [chemical binding]; other site 1211025006132 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1211025006133 active site 1211025006134 ATP binding site [chemical binding]; other site 1211025006135 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1211025006136 6-phosphofructokinase 2; Provisional; Region: PRK10294 1211025006137 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1211025006138 putative substrate binding site [chemical binding]; other site 1211025006139 putative ATP binding site [chemical binding]; other site 1211025006140 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1211025006141 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1211025006142 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1211025006143 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1211025006144 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1211025006145 active site 1211025006146 dimer interface [polypeptide binding]; other site 1211025006147 motif 1; other site 1211025006148 motif 2; other site 1211025006149 motif 3; other site 1211025006150 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1211025006151 anticodon binding site; other site 1211025006152 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1211025006153 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1211025006154 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1211025006155 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1211025006156 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1211025006157 23S rRNA binding site [nucleotide binding]; other site 1211025006158 L21 binding site [polypeptide binding]; other site 1211025006159 L13 binding site [polypeptide binding]; other site 1211025006160 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1211025006161 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1211025006162 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1211025006163 dimer interface [polypeptide binding]; other site 1211025006164 motif 1; other site 1211025006165 active site 1211025006166 motif 2; other site 1211025006167 motif 3; other site 1211025006168 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1211025006169 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1211025006170 putative tRNA-binding site [nucleotide binding]; other site 1211025006171 B3/4 domain; Region: B3_4; pfam03483 1211025006172 tRNA synthetase B5 domain; Region: B5; smart00874 1211025006173 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1211025006174 dimer interface [polypeptide binding]; other site 1211025006175 motif 1; other site 1211025006176 motif 3; other site 1211025006177 motif 2; other site 1211025006178 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1211025006179 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1211025006180 IHF dimer interface [polypeptide binding]; other site 1211025006181 IHF - DNA interface [nucleotide binding]; other site 1211025006182 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1211025006183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025006184 ABC-ATPase subunit interface; other site 1211025006185 dimer interface [polypeptide binding]; other site 1211025006186 putative PBP binding regions; other site 1211025006187 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1211025006188 catalytic residues [active] 1211025006189 dimer interface [polypeptide binding]; other site 1211025006190 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1211025006191 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1211025006192 Walker A/P-loop; other site 1211025006193 ATP binding site [chemical binding]; other site 1211025006194 Q-loop/lid; other site 1211025006195 ABC transporter signature motif; other site 1211025006196 Walker B; other site 1211025006197 D-loop; other site 1211025006198 H-loop/switch region; other site 1211025006199 NlpC/P60 family; Region: NLPC_P60; pfam00877 1211025006200 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1211025006201 potential frameshift: common BLAST hit: gi|365970121|ref|YP_004951682.1| protein YdiU 1211025006202 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1211025006203 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1211025006204 NAD binding site [chemical binding]; other site 1211025006205 homotetramer interface [polypeptide binding]; other site 1211025006206 homodimer interface [polypeptide binding]; other site 1211025006207 substrate binding site [chemical binding]; other site 1211025006208 active site 1211025006209 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1211025006210 putative acyltransferase; Provisional; Region: PRK05790 1211025006211 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1211025006212 dimer interface [polypeptide binding]; other site 1211025006213 active site 1211025006214 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1211025006215 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1211025006216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025006217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025006218 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1211025006219 putative dimerization interface [polypeptide binding]; other site 1211025006220 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1211025006221 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1211025006222 Walker A/P-loop; other site 1211025006223 ATP binding site [chemical binding]; other site 1211025006224 Q-loop/lid; other site 1211025006225 ABC transporter signature motif; other site 1211025006226 Walker B; other site 1211025006227 D-loop; other site 1211025006228 H-loop/switch region; other site 1211025006229 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1211025006230 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025006231 ABC-ATPase subunit interface; other site 1211025006232 dimer interface [polypeptide binding]; other site 1211025006233 putative PBP binding regions; other site 1211025006234 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1211025006235 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1211025006236 putative hemin binding site; other site 1211025006237 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1211025006238 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1211025006239 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1211025006240 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1211025006241 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025006242 N-terminal plug; other site 1211025006243 ligand-binding site [chemical binding]; other site 1211025006244 Hemin uptake protein hemP; Region: hemP; cl10043 1211025006245 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1211025006246 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1211025006247 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1211025006248 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1211025006249 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1211025006250 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1211025006251 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1211025006252 putative symporter YagG; Provisional; Region: PRK09669 1211025006253 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1211025006254 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1211025006255 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1211025006256 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1211025006257 putative inner membrane protein; Provisional; Region: PRK10983 1211025006258 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1211025006259 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1211025006260 FAD binding domain; Region: FAD_binding_4; pfam01565 1211025006261 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1211025006262 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1211025006263 CoenzymeA binding site [chemical binding]; other site 1211025006264 subunit interaction site [polypeptide binding]; other site 1211025006265 PHB binding site; other site 1211025006266 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1211025006267 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1211025006268 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1211025006269 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1211025006270 ligand binding site [chemical binding]; other site 1211025006271 flexible hinge region; other site 1211025006272 Fimbrial protein; Region: Fimbrial; cl01416 1211025006273 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1211025006274 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025006275 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025006276 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1211025006277 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025006278 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025006279 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025006280 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1211025006281 Fimbrial protein; Region: Fimbrial; cl01416 1211025006282 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1211025006283 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025006284 DNA binding residues [nucleotide binding] 1211025006285 dimerization interface [polypeptide binding]; other site 1211025006286 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1211025006287 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1211025006288 [4Fe-4S] binding site [ion binding]; other site 1211025006289 molybdopterin cofactor binding site; other site 1211025006290 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1211025006291 molybdopterin cofactor binding site; other site 1211025006292 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1211025006293 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1211025006294 Sensors of blue-light using FAD; Region: BLUF; smart01034 1211025006295 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025006296 transcriptional regulator MirA; Provisional; Region: PRK15043 1211025006297 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1211025006298 DNA binding residues [nucleotide binding] 1211025006299 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1211025006300 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1211025006301 putative ABC transporter; Region: ycf24; CHL00085 1211025006302 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1211025006303 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1211025006304 Walker A/P-loop; other site 1211025006305 ATP binding site [chemical binding]; other site 1211025006306 Q-loop/lid; other site 1211025006307 ABC transporter signature motif; other site 1211025006308 Walker B; other site 1211025006309 D-loop; other site 1211025006310 H-loop/switch region; other site 1211025006311 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1211025006312 FeS assembly protein SufD; Region: sufD; TIGR01981 1211025006313 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1211025006314 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1211025006315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1211025006316 catalytic residue [active] 1211025006317 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1211025006318 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1211025006319 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1211025006320 murein lipoprotein; Provisional; Region: PRK15396 1211025006321 pyruvate kinase; Provisional; Region: PRK09206 1211025006322 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1211025006323 domain interfaces; other site 1211025006324 active site 1211025006325 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1211025006326 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1211025006327 homodimer interface [polypeptide binding]; other site 1211025006328 substrate-cofactor binding pocket; other site 1211025006329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025006330 catalytic residue [active] 1211025006331 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1211025006332 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1211025006333 dimer interface [polypeptide binding]; other site 1211025006334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025006335 catalytic residue [active] 1211025006336 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1211025006337 FOG: CBS domain [General function prediction only]; Region: COG0517 1211025006338 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1211025006339 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1211025006340 Walker A/P-loop; other site 1211025006341 ATP binding site [chemical binding]; other site 1211025006342 Q-loop/lid; other site 1211025006343 ABC transporter signature motif; other site 1211025006344 Walker B; other site 1211025006345 D-loop; other site 1211025006346 H-loop/switch region; other site 1211025006347 NIL domain; Region: NIL; pfam09383 1211025006348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025006349 dimer interface [polypeptide binding]; other site 1211025006350 conserved gate region; other site 1211025006351 putative PBP binding loops; other site 1211025006352 ABC-ATPase subunit interface; other site 1211025006353 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1211025006354 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1211025006355 hypothetical protein; Provisional; Region: PRK10292 1211025006356 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1211025006357 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1211025006358 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1211025006359 active site clefts [active] 1211025006360 zinc binding site [ion binding]; other site 1211025006361 dimer interface [polypeptide binding]; other site 1211025006362 hypothetical protein; Provisional; Region: PRK09897 1211025006363 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1211025006364 multidrug efflux protein; Reviewed; Region: PRK01766 1211025006365 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1211025006366 cation binding site [ion binding]; other site 1211025006367 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1211025006368 Lumazine binding domain; Region: Lum_binding; pfam00677 1211025006369 Lumazine binding domain; Region: Lum_binding; pfam00677 1211025006370 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1211025006371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1211025006372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025006373 S-adenosylmethionine binding site [chemical binding]; other site 1211025006374 putative transporter; Provisional; Region: PRK11043 1211025006375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025006376 putative substrate translocation pore; other site 1211025006377 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1211025006378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025006379 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025006380 dimerization interface [polypeptide binding]; other site 1211025006381 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1211025006382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025006383 DNA binding site [nucleotide binding] 1211025006384 domain linker motif; other site 1211025006385 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1211025006386 dimerization interface [polypeptide binding]; other site 1211025006387 ligand binding site [chemical binding]; other site 1211025006388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025006389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025006390 putative substrate translocation pore; other site 1211025006391 superoxide dismutase; Provisional; Region: PRK10543 1211025006392 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1211025006393 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1211025006394 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1211025006395 NlpC/P60 family; Region: NLPC_P60; pfam00877 1211025006396 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1211025006397 putative GSH binding site [chemical binding]; other site 1211025006398 catalytic residues [active] 1211025006399 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1211025006400 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1211025006401 dimer interface [polypeptide binding]; other site 1211025006402 catalytic site [active] 1211025006403 putative active site [active] 1211025006404 putative substrate binding site [chemical binding]; other site 1211025006405 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1211025006406 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1211025006407 dimer interface [polypeptide binding]; other site 1211025006408 active site 1211025006409 metal binding site [ion binding]; metal-binding site 1211025006410 glutathione binding site [chemical binding]; other site 1211025006411 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1211025006412 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1211025006413 FMN binding site [chemical binding]; other site 1211025006414 active site 1211025006415 substrate binding site [chemical binding]; other site 1211025006416 catalytic residue [active] 1211025006417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1211025006418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025006419 putative metal dependent hydrolase; Provisional; Region: PRK11598 1211025006420 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1211025006421 Sulfatase; Region: Sulfatase; pfam00884 1211025006422 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1211025006423 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1211025006424 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1211025006425 active site 1211025006426 catalytic tetrad [active] 1211025006427 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1211025006428 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1211025006429 E-class dimer interface [polypeptide binding]; other site 1211025006430 P-class dimer interface [polypeptide binding]; other site 1211025006431 active site 1211025006432 Cu2+ binding site [ion binding]; other site 1211025006433 Zn2+ binding site [ion binding]; other site 1211025006434 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1211025006435 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1211025006436 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1211025006437 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025006438 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025006439 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1211025006440 transcriptional regulator SlyA; Provisional; Region: PRK03573 1211025006441 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1211025006442 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025006443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025006444 metal binding site [ion binding]; metal-binding site 1211025006445 active site 1211025006446 I-site; other site 1211025006447 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1211025006448 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 1211025006449 lysozyme inhibitor; Provisional; Region: PRK11372 1211025006450 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1211025006451 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1211025006452 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1211025006453 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1211025006454 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1211025006455 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1211025006456 active site 1211025006457 HIGH motif; other site 1211025006458 dimer interface [polypeptide binding]; other site 1211025006459 KMSKS motif; other site 1211025006460 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1211025006461 RNA binding surface [nucleotide binding]; other site 1211025006462 pyridoxamine kinase; Validated; Region: PRK05756 1211025006463 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1211025006464 dimer interface [polypeptide binding]; other site 1211025006465 pyridoxal binding site [chemical binding]; other site 1211025006466 ATP binding site [chemical binding]; other site 1211025006467 glutathionine S-transferase; Provisional; Region: PRK10542 1211025006468 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1211025006469 C-terminal domain interface [polypeptide binding]; other site 1211025006470 GSH binding site (G-site) [chemical binding]; other site 1211025006471 dimer interface [polypeptide binding]; other site 1211025006472 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1211025006473 N-terminal domain interface [polypeptide binding]; other site 1211025006474 dimer interface [polypeptide binding]; other site 1211025006475 substrate binding pocket (H-site) [chemical binding]; other site 1211025006476 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1211025006477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025006478 putative substrate translocation pore; other site 1211025006479 POT family; Region: PTR2; pfam00854 1211025006480 endonuclease III; Provisional; Region: PRK10702 1211025006481 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1211025006482 minor groove reading motif; other site 1211025006483 helix-hairpin-helix signature motif; other site 1211025006484 substrate binding pocket [chemical binding]; other site 1211025006485 active site 1211025006486 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1211025006487 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1211025006488 electron transport complex protein RnfG; Validated; Region: PRK01908 1211025006489 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1211025006490 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1211025006491 SLBB domain; Region: SLBB; pfam10531 1211025006492 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1211025006493 electron transport complex protein RnfB; Provisional; Region: PRK05113 1211025006494 Putative Fe-S cluster; Region: FeS; cl17515 1211025006495 4Fe-4S binding domain; Region: Fer4; pfam00037 1211025006496 electron transport complex protein RsxA; Provisional; Region: PRK05151 1211025006497 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1211025006498 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1211025006499 putative oxidoreductase; Provisional; Region: PRK11579 1211025006500 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025006501 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1211025006502 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1211025006503 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1211025006504 active site 1211025006505 purine riboside binding site [chemical binding]; other site 1211025006506 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1211025006507 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025006508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025006509 homodimer interface [polypeptide binding]; other site 1211025006510 catalytic residue [active] 1211025006511 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1211025006512 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1211025006513 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025006514 active site turn [active] 1211025006515 phosphorylation site [posttranslational modification] 1211025006516 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1211025006517 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025006518 DNA binding site [nucleotide binding] 1211025006519 domain linker motif; other site 1211025006520 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1211025006521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1211025006522 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1211025006523 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1211025006524 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1211025006525 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1211025006526 fumarate hydratase; Provisional; Region: PRK15389 1211025006527 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1211025006528 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1211025006529 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1211025006530 Class II fumarases; Region: Fumarase_classII; cd01362 1211025006531 active site 1211025006532 tetramer interface [polypeptide binding]; other site 1211025006533 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1211025006534 sensor protein RstB; Provisional; Region: PRK10604 1211025006535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025006536 dimerization interface [polypeptide binding]; other site 1211025006537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025006538 dimer interface [polypeptide binding]; other site 1211025006539 phosphorylation site [posttranslational modification] 1211025006540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025006541 ATP binding site [chemical binding]; other site 1211025006542 Mg2+ binding site [ion binding]; other site 1211025006543 G-X-G motif; other site 1211025006544 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1211025006545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025006546 active site 1211025006547 phosphorylation site [posttranslational modification] 1211025006548 intermolecular recognition site; other site 1211025006549 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025006550 DNA binding site [nucleotide binding] 1211025006551 GlpM protein; Region: GlpM; pfam06942 1211025006552 dihydromonapterin reductase; Provisional; Region: PRK06483 1211025006553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1211025006554 NAD(P) binding site [chemical binding]; other site 1211025006555 active site 1211025006556 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1211025006557 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1211025006558 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1211025006559 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1211025006560 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1211025006561 ligand binding site [chemical binding]; other site 1211025006562 homodimer interface [polypeptide binding]; other site 1211025006563 NAD(P) binding site [chemical binding]; other site 1211025006564 trimer interface B [polypeptide binding]; other site 1211025006565 trimer interface A [polypeptide binding]; other site 1211025006566 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1211025006567 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1211025006568 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1211025006569 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1211025006570 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1211025006571 universal stress protein UspE; Provisional; Region: PRK11175 1211025006572 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1211025006573 Ligand Binding Site [chemical binding]; other site 1211025006574 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1211025006575 Ligand Binding Site [chemical binding]; other site 1211025006576 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1211025006577 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1211025006578 ligand binding site [chemical binding]; other site 1211025006579 flexible hinge region; other site 1211025006580 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1211025006581 putative switch regulator; other site 1211025006582 non-specific DNA interactions [nucleotide binding]; other site 1211025006583 DNA binding site [nucleotide binding] 1211025006584 sequence specific DNA binding site [nucleotide binding]; other site 1211025006585 putative cAMP binding site [chemical binding]; other site 1211025006586 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1211025006587 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1211025006588 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1211025006589 DNA binding site [nucleotide binding] 1211025006590 active site 1211025006591 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 1211025006592 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1211025006593 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1211025006594 amidohydrolase; Region: amidohydrolases; TIGR01891 1211025006595 putative metal binding site [ion binding]; other site 1211025006596 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1211025006597 amidohydrolase; Region: amidohydrolases; TIGR01891 1211025006598 putative metal binding site [ion binding]; other site 1211025006599 dimer interface [polypeptide binding]; other site 1211025006600 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1211025006601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025006602 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1211025006603 putative substrate binding pocket [chemical binding]; other site 1211025006604 putative dimerization interface [polypeptide binding]; other site 1211025006605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1211025006606 Smr domain; Region: Smr; pfam01713 1211025006607 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1211025006608 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1211025006609 dimer interface [polypeptide binding]; other site 1211025006610 ligand binding site [chemical binding]; other site 1211025006611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025006612 dimerization interface [polypeptide binding]; other site 1211025006613 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025006614 dimer interface [polypeptide binding]; other site 1211025006615 putative CheW interface [polypeptide binding]; other site 1211025006616 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1211025006617 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1211025006618 active site 1211025006619 catalytic tetrad [active] 1211025006620 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1211025006621 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1211025006622 Catalytic site [active] 1211025006623 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1211025006624 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1211025006625 active site 1211025006626 DNA binding site [nucleotide binding] 1211025006627 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1211025006628 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1211025006629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025006630 DNA-binding site [nucleotide binding]; DNA binding site 1211025006631 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025006632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025006633 homodimer interface [polypeptide binding]; other site 1211025006634 catalytic residue [active] 1211025006635 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1211025006636 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1211025006637 active site 1211025006638 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1211025006639 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1211025006640 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1211025006641 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1211025006642 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1211025006643 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1211025006644 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1211025006645 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1211025006646 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1211025006647 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1211025006648 active site 1211025006649 Zn binding site [ion binding]; other site 1211025006650 4-aminobutyrate transaminase; Provisional; Region: PRK09792 1211025006651 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1211025006652 inhibitor-cofactor binding pocket; inhibition site 1211025006653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025006654 catalytic residue [active] 1211025006655 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1211025006656 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1211025006657 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1211025006658 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1211025006659 NAD(P) binding site [chemical binding]; other site 1211025006660 catalytic residues [active] 1211025006661 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1211025006662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025006663 non-specific DNA binding site [nucleotide binding]; other site 1211025006664 salt bridge; other site 1211025006665 sequence-specific DNA binding site [nucleotide binding]; other site 1211025006666 Cupin domain; Region: Cupin_2; pfam07883 1211025006667 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 1211025006668 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1211025006669 catalytic triad [active] 1211025006670 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1211025006671 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1211025006672 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1211025006673 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1211025006674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025006675 putative substrate translocation pore; other site 1211025006676 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1211025006677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025006678 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1211025006679 dimerization interface [polypeptide binding]; other site 1211025006680 substrate binding pocket [chemical binding]; other site 1211025006681 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1211025006682 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1211025006683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1211025006684 nucleotide binding site [chemical binding]; other site 1211025006685 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1211025006686 AAA domain; Region: AAA_26; pfam13500 1211025006687 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1211025006688 Cl- selectivity filter; other site 1211025006689 Cl- binding residues [ion binding]; other site 1211025006690 pore gating glutamate residue; other site 1211025006691 dimer interface [polypeptide binding]; other site 1211025006692 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1211025006693 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1211025006694 Walker A/P-loop; other site 1211025006695 ATP binding site [chemical binding]; other site 1211025006696 Q-loop/lid; other site 1211025006697 ABC transporter signature motif; other site 1211025006698 Walker B; other site 1211025006699 D-loop; other site 1211025006700 H-loop/switch region; other site 1211025006701 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1211025006702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025006703 dimer interface [polypeptide binding]; other site 1211025006704 conserved gate region; other site 1211025006705 ABC-ATPase subunit interface; other site 1211025006706 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1211025006707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025006708 dimer interface [polypeptide binding]; other site 1211025006709 conserved gate region; other site 1211025006710 putative PBP binding loops; other site 1211025006711 ABC-ATPase subunit interface; other site 1211025006712 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1211025006713 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1211025006714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025006715 putative substrate translocation pore; other site 1211025006716 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1211025006717 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1211025006718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025006719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025006720 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1211025006721 putative effector binding pocket; other site 1211025006722 putative dimerization interface [polypeptide binding]; other site 1211025006723 Chloramphenicol acetyltransferase; Region: CAT; cl02008 1211025006724 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1211025006725 YebG protein; Region: YebG; pfam07130 1211025006726 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1211025006727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025006728 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1211025006729 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025006730 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025006731 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1211025006732 Predicted transcriptional regulator [Transcription]; Region: COG1959 1211025006733 Transcriptional regulator; Region: Rrf2; pfam02082 1211025006734 Transcriptional regulator; Region: Rrf2; cl17282 1211025006735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1211025006736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025006737 ATP binding site [chemical binding]; other site 1211025006738 Mg2+ binding site [ion binding]; other site 1211025006739 G-X-G motif; other site 1211025006740 integrase; Provisional; Region: PRK09692 1211025006741 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1211025006742 active site 1211025006743 Int/Topo IB signature motif; other site 1211025006744 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 1211025006745 HicB family; Region: HicB; pfam05534 1211025006746 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1211025006747 AAA domain; Region: AAA_25; pfam13481 1211025006748 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1211025006749 Walker A motif; other site 1211025006750 ATP binding site [chemical binding]; other site 1211025006751 Walker B motif; other site 1211025006752 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1211025006753 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1211025006754 oligomer interface [polypeptide binding]; other site 1211025006755 active site residues [active] 1211025006756 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1211025006757 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1211025006758 potential frameshift: common BLAST hit: gi|146311516|ref|YP_001176590.1| integral membrane sensor signal transduction histidine kinase 1211025006759 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1211025006760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025006761 active site 1211025006762 phosphorylation site [posttranslational modification] 1211025006763 intermolecular recognition site; other site 1211025006764 dimerization interface [polypeptide binding]; other site 1211025006765 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025006766 DNA binding site [nucleotide binding] 1211025006767 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1211025006768 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1211025006769 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1211025006770 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1211025006771 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1211025006772 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1211025006773 putative [Fe4-S4] binding site [ion binding]; other site 1211025006774 putative molybdopterin cofactor binding site [chemical binding]; other site 1211025006775 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1211025006776 putative molybdopterin cofactor binding site; other site 1211025006777 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1211025006778 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1211025006779 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1211025006780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025006781 Coenzyme A binding pocket [chemical binding]; other site 1211025006782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1211025006783 hypothetical protein; Provisional; Region: PRK13659 1211025006784 hypothetical protein; Provisional; Region: PRK02237 1211025006785 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1211025006786 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1211025006787 putative active site pocket [active] 1211025006788 putative metal binding site [ion binding]; other site 1211025006789 putative oxidoreductase; Provisional; Region: PRK10083 1211025006790 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1211025006791 putative NAD(P) binding site [chemical binding]; other site 1211025006792 catalytic Zn binding site [ion binding]; other site 1211025006793 structural Zn binding site [ion binding]; other site 1211025006794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025006795 metabolite-proton symporter; Region: 2A0106; TIGR00883 1211025006796 putative substrate translocation pore; other site 1211025006797 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1211025006798 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1211025006799 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1211025006800 YdfZ protein; Region: YdfZ; pfam14001 1211025006801 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1211025006802 Ligand Binding Site [chemical binding]; other site 1211025006803 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1211025006804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025006805 DNA-binding site [nucleotide binding]; DNA binding site 1211025006806 FCD domain; Region: FCD; pfam07729 1211025006807 malonic semialdehyde reductase; Provisional; Region: PRK10538 1211025006808 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1211025006809 putative NAD(P) binding site [chemical binding]; other site 1211025006810 homodimer interface [polypeptide binding]; other site 1211025006811 homotetramer interface [polypeptide binding]; other site 1211025006812 active site 1211025006813 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1211025006814 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1211025006815 active site 1211025006816 Zn binding site [ion binding]; other site 1211025006817 CHASE4 domain; Region: CHASE4; pfam05228 1211025006818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025006819 putative active site [active] 1211025006820 heme pocket [chemical binding]; other site 1211025006821 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025006822 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025006823 metal binding site [ion binding]; metal-binding site 1211025006824 active site 1211025006825 I-site; other site 1211025006826 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025006827 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1211025006828 Ligand Binding Site [chemical binding]; other site 1211025006829 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1211025006830 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1211025006831 MarR family; Region: MarR_2; pfam12802 1211025006832 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1211025006833 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1211025006834 putative ligand binding site [chemical binding]; other site 1211025006835 putative NAD binding site [chemical binding]; other site 1211025006836 catalytic site [active] 1211025006837 hypothetical protein; Provisional; Region: PRK10695 1211025006838 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1211025006839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1211025006840 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1211025006841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025006842 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1211025006843 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1211025006844 NAD(P) binding site [chemical binding]; other site 1211025006845 catalytic residues [active] 1211025006846 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025006847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025006848 metal binding site [ion binding]; metal-binding site 1211025006849 active site 1211025006850 I-site; other site 1211025006851 tyramine oxidase; Provisional; Region: tynA; PRK14696 1211025006852 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1211025006853 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1211025006854 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1211025006855 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1211025006856 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1211025006857 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1211025006858 substrate binding site [chemical binding]; other site 1211025006859 dimer interface [polypeptide binding]; other site 1211025006860 NADP binding site [chemical binding]; other site 1211025006861 catalytic residues [active] 1211025006862 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1211025006863 substrate binding site [chemical binding]; other site 1211025006864 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1211025006865 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1211025006866 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1211025006867 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1211025006868 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1211025006869 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1211025006870 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1211025006871 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1211025006872 FAD binding pocket [chemical binding]; other site 1211025006873 FAD binding motif [chemical binding]; other site 1211025006874 phosphate binding motif [ion binding]; other site 1211025006875 beta-alpha-beta structure motif; other site 1211025006876 NAD(p) ribose binding residues [chemical binding]; other site 1211025006877 NAD binding pocket [chemical binding]; other site 1211025006878 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1211025006879 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1211025006880 catalytic loop [active] 1211025006881 iron binding site [ion binding]; other site 1211025006882 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 1211025006883 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1211025006884 substrate binding site [chemical binding]; other site 1211025006885 oxyanion hole (OAH) forming residues; other site 1211025006886 trimer interface [polypeptide binding]; other site 1211025006887 enoyl-CoA hydratase; Provisional; Region: PRK08140 1211025006888 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1211025006889 substrate binding site [chemical binding]; other site 1211025006890 oxyanion hole (OAH) forming residues; other site 1211025006891 trimer interface [polypeptide binding]; other site 1211025006892 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1211025006893 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1211025006894 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1211025006895 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1211025006896 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1211025006897 CoenzymeA binding site [chemical binding]; other site 1211025006898 subunit interaction site [polypeptide binding]; other site 1211025006899 PHB binding site; other site 1211025006900 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1211025006901 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1211025006902 dimer interface [polypeptide binding]; other site 1211025006903 active site 1211025006904 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1211025006905 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1211025006906 active site 1211025006907 AMP binding site [chemical binding]; other site 1211025006908 homodimer interface [polypeptide binding]; other site 1211025006909 acyl-activating enzyme (AAE) consensus motif; other site 1211025006910 CoA binding site [chemical binding]; other site 1211025006911 PaaX-like protein; Region: PaaX; pfam07848 1211025006912 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1211025006913 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1211025006914 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 1211025006915 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1211025006916 putative trimer interface [polypeptide binding]; other site 1211025006917 putative metal binding site [ion binding]; other site 1211025006918 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1211025006919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025006920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025006921 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1211025006922 putative effector binding pocket; other site 1211025006923 putative dimerization interface [polypeptide binding]; other site 1211025006924 phosphodiesterase YaeI; Provisional; Region: PRK11340 1211025006925 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1211025006926 putative active site [active] 1211025006927 putative metal binding site [ion binding]; other site 1211025006928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025006929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025006930 putative substrate translocation pore; other site 1211025006931 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1211025006932 classical (c) SDRs; Region: SDR_c; cd05233 1211025006933 NAD(P) binding site [chemical binding]; other site 1211025006934 active site 1211025006935 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1211025006936 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1211025006937 classical (c) SDRs; Region: SDR_c; cd05233 1211025006938 NAD(P) binding site [chemical binding]; other site 1211025006939 active site 1211025006940 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1211025006941 extended (e) SDRs; Region: SDR_e; cd08946 1211025006942 NAD(P) binding site [chemical binding]; other site 1211025006943 active site 1211025006944 substrate binding site [chemical binding]; other site 1211025006945 DinB family; Region: DinB; cl17821 1211025006946 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1211025006947 catalytic residues [active] 1211025006948 dimer interface [polypeptide binding]; other site 1211025006949 TolA C-terminal; Region: TolA; pfam06519 1211025006950 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1211025006951 homotrimer interaction site [polypeptide binding]; other site 1211025006952 putative active site [active] 1211025006953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1211025006954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025006955 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1211025006956 active site 1211025006957 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1211025006958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025006959 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1211025006960 MarR family; Region: MarR_2; cl17246 1211025006961 potential frameshift: common BLAST hit: gi|296102469|ref|YP_003612615.1| transcriptional regulator 1211025006962 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1211025006963 Isochorismatase family; Region: Isochorismatase; pfam00857 1211025006964 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1211025006965 catalytic triad [active] 1211025006966 conserved cis-peptide bond; other site 1211025006967 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1211025006968 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1211025006969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1211025006970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025006971 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1211025006972 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1211025006973 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025006974 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025006975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1211025006976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025006977 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1211025006978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1211025006979 NAD(P) binding site [chemical binding]; other site 1211025006980 active site 1211025006981 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1211025006982 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1211025006983 DNA binding residues [nucleotide binding] 1211025006984 dimer interface [polypeptide binding]; other site 1211025006985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025006986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025006987 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1211025006988 putative effector binding pocket; other site 1211025006989 dimerization interface [polypeptide binding]; other site 1211025006990 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1211025006991 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1211025006992 FMN binding site [chemical binding]; other site 1211025006993 active site 1211025006994 substrate binding site [chemical binding]; other site 1211025006995 catalytic residue [active] 1211025006996 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1211025006997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1211025006998 SnoaL-like domain; Region: SnoaL_2; pfam12680 1211025006999 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1211025007000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025007001 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1211025007002 SnoaL-like domain; Region: SnoaL_2; pfam12680 1211025007003 short chain dehydrogenase; Provisional; Region: PRK06101 1211025007004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1211025007005 NAD(P) binding site [chemical binding]; other site 1211025007006 active site 1211025007007 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1211025007008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1211025007009 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1211025007010 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1211025007011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025007012 S-adenosylmethionine binding site [chemical binding]; other site 1211025007013 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1211025007014 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1211025007015 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1211025007016 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1211025007017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025007018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025007019 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1211025007020 putative effector binding pocket; other site 1211025007021 dimerization interface [polypeptide binding]; other site 1211025007022 methionine synthase; Provisional; Region: PRK01207 1211025007023 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1211025007024 substrate binding site [chemical binding]; other site 1211025007025 THF binding site; other site 1211025007026 zinc-binding site [ion binding]; other site 1211025007027 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1211025007028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1211025007029 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1211025007030 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1211025007031 active site 1211025007032 azoreductase; Reviewed; Region: PRK00170 1211025007033 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1211025007034 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1211025007035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025007036 ATP binding site [chemical binding]; other site 1211025007037 putative Mg++ binding site [ion binding]; other site 1211025007038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025007039 nucleotide binding region [chemical binding]; other site 1211025007040 ATP-binding site [chemical binding]; other site 1211025007041 Helicase associated domain (HA2); Region: HA2; pfam04408 1211025007042 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1211025007043 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1211025007044 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1211025007045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1211025007046 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1211025007047 potential frameshift: common BLAST hit: gi|345299244|ref|YP_004828602.1| secretion protein HlyD family protein 1211025007048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025007049 putative substrate translocation pore; other site 1211025007050 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1211025007051 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1211025007052 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1211025007053 putative active site [active] 1211025007054 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1211025007055 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1211025007056 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1211025007057 cytochrome b561; Provisional; Region: PRK11513 1211025007058 putative oxidoreductase; Provisional; Region: PRK11579 1211025007059 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025007060 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1211025007061 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1211025007062 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1211025007063 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1211025007064 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1211025007065 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007066 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007067 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007068 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007069 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007070 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007071 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007072 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007073 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007074 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007075 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007076 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007077 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007078 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007079 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007080 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007081 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007082 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007083 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007084 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007085 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007086 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007087 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007088 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007089 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007090 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007091 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007092 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1211025007093 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007094 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007095 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025007096 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1211025007097 Family description; Region: VCBS; pfam13517 1211025007098 Family description; Region: VCBS; pfam13517 1211025007099 Family description; Region: VCBS; pfam13517 1211025007100 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1211025007101 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1211025007102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025007103 Walker A/P-loop; other site 1211025007104 ATP binding site [chemical binding]; other site 1211025007105 Q-loop/lid; other site 1211025007106 ABC transporter signature motif; other site 1211025007107 Walker B; other site 1211025007108 D-loop; other site 1211025007109 H-loop/switch region; other site 1211025007110 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1211025007111 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025007112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025007113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1211025007114 DNA binding residues [nucleotide binding] 1211025007115 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025007116 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1211025007117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025007118 Coenzyme A binding pocket [chemical binding]; other site 1211025007119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1211025007120 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1211025007121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025007122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025007123 dimerization interface [polypeptide binding]; other site 1211025007124 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1211025007125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025007126 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1211025007127 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1211025007128 putative metal binding site [ion binding]; other site 1211025007129 putative homodimer interface [polypeptide binding]; other site 1211025007130 putative homotetramer interface [polypeptide binding]; other site 1211025007131 putative homodimer-homodimer interface [polypeptide binding]; other site 1211025007132 putative allosteric switch controlling residues; other site 1211025007133 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1211025007134 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1211025007135 substrate binding site [chemical binding]; other site 1211025007136 catalytic Zn binding site [ion binding]; other site 1211025007137 NAD binding site [chemical binding]; other site 1211025007138 structural Zn binding site [ion binding]; other site 1211025007139 dimer interface [polypeptide binding]; other site 1211025007140 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1211025007141 dimer interface [polypeptide binding]; other site 1211025007142 ligand binding site [chemical binding]; other site 1211025007143 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1211025007144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025007145 dimerization interface [polypeptide binding]; other site 1211025007146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025007147 dimer interface [polypeptide binding]; other site 1211025007148 putative CheW interface [polypeptide binding]; other site 1211025007149 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1211025007150 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1211025007151 Trp docking motif [polypeptide binding]; other site 1211025007152 putative active site [active] 1211025007153 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1211025007154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025007155 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1211025007156 putative dimerization interface [polypeptide binding]; other site 1211025007157 short chain dehydrogenase; Provisional; Region: PRK06701 1211025007158 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1211025007159 NAD binding site [chemical binding]; other site 1211025007160 metal binding site [ion binding]; metal-binding site 1211025007161 active site 1211025007162 hypothetical protein; Provisional; Region: PRK10053 1211025007163 Predicted membrane protein [Function unknown]; Region: COG2323 1211025007164 hypothetical protein; Validated; Region: PRK03657 1211025007165 short chain dehydrogenase; Provisional; Region: PRK07109 1211025007166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1211025007167 NAD(P) binding site [chemical binding]; other site 1211025007168 active site 1211025007169 potential frameshift: common BLAST hit: gi|296102404|ref|YP_003612550.1| trehalose synthase 1211025007170 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1211025007171 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1211025007172 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1211025007173 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1211025007174 dimanganese center [ion binding]; other site 1211025007175 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1211025007176 dinuclear metal binding motif [ion binding]; other site 1211025007177 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1211025007178 dinuclear metal binding motif [ion binding]; other site 1211025007179 General stress protein [General function prediction only]; Region: GsiB; COG3729 1211025007180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1211025007181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1211025007182 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1211025007183 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1211025007184 substrate binding pocket [chemical binding]; other site 1211025007185 catalytic triad [active] 1211025007186 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1211025007187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025007188 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025007189 dimerization interface [polypeptide binding]; other site 1211025007190 putative aminotransferase; Provisional; Region: PRK12414 1211025007191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025007192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025007193 homodimer interface [polypeptide binding]; other site 1211025007194 catalytic residue [active] 1211025007195 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1211025007196 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025007197 substrate binding pocket [chemical binding]; other site 1211025007198 membrane-bound complex binding site; other site 1211025007199 hinge residues; other site 1211025007200 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1211025007201 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 1211025007202 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1211025007203 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1211025007204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025007205 Coenzyme A binding pocket [chemical binding]; other site 1211025007206 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1211025007207 putative trimer interface [polypeptide binding]; other site 1211025007208 putative CoA binding site [chemical binding]; other site 1211025007209 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1211025007210 putative trimer interface [polypeptide binding]; other site 1211025007211 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1211025007212 putative trimer interface [polypeptide binding]; other site 1211025007213 putative CoA binding site [chemical binding]; other site 1211025007214 putative CoA binding site [chemical binding]; other site 1211025007215 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1211025007216 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1211025007217 gating phenylalanine in ion channel; other site 1211025007218 tellurite resistance protein TehB; Provisional; Region: PRK11207 1211025007219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025007220 S-adenosylmethionine binding site [chemical binding]; other site 1211025007221 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1211025007222 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1211025007223 metal binding site [ion binding]; metal-binding site 1211025007224 dimer interface [polypeptide binding]; other site 1211025007225 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1211025007226 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1211025007227 peptide binding site [polypeptide binding]; other site 1211025007228 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1211025007229 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1211025007230 EamA-like transporter family; Region: EamA; pfam00892 1211025007231 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1211025007232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025007233 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1211025007234 benzoate transporter; Region: benE; TIGR00843 1211025007235 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1211025007236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025007237 non-specific DNA binding site [nucleotide binding]; other site 1211025007238 salt bridge; other site 1211025007239 sequence-specific DNA binding site [nucleotide binding]; other site 1211025007240 Cupin domain; Region: Cupin_2; pfam07883 1211025007241 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1211025007242 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1211025007243 Peptidase family U32; Region: Peptidase_U32; pfam01136 1211025007244 Collagenase; Region: DUF3656; pfam12392 1211025007245 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1211025007246 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1211025007247 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1211025007248 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1211025007249 conserved cys residue [active] 1211025007250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025007251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025007252 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1211025007253 active site residue [active] 1211025007254 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1211025007255 substrate binding site [chemical binding]; other site 1211025007256 THF binding site; other site 1211025007257 zinc-binding site [ion binding]; other site 1211025007258 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1211025007259 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1211025007260 putative ligand binding site [chemical binding]; other site 1211025007261 HEAT repeats; Region: HEAT_2; pfam13646 1211025007262 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1211025007263 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025007264 TM-ABC transporter signature motif; other site 1211025007265 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1211025007266 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1211025007267 TM-ABC transporter signature motif; other site 1211025007268 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1211025007269 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1211025007270 Walker A/P-loop; other site 1211025007271 ATP binding site [chemical binding]; other site 1211025007272 Q-loop/lid; other site 1211025007273 ABC transporter signature motif; other site 1211025007274 Walker B; other site 1211025007275 D-loop; other site 1211025007276 H-loop/switch region; other site 1211025007277 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1211025007278 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1211025007279 Walker A/P-loop; other site 1211025007280 ATP binding site [chemical binding]; other site 1211025007281 Q-loop/lid; other site 1211025007282 ABC transporter signature motif; other site 1211025007283 Walker B; other site 1211025007284 D-loop; other site 1211025007285 H-loop/switch region; other site 1211025007286 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1211025007287 putative transporter; Provisional; Region: PRK10054 1211025007288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025007289 putative substrate translocation pore; other site 1211025007290 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1211025007291 EamA-like transporter family; Region: EamA; pfam00892 1211025007292 EamA-like transporter family; Region: EamA; pfam00892 1211025007293 hypothetical protein; Provisional; Region: PRK10106 1211025007294 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1211025007295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025007296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025007297 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1211025007298 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1211025007299 inner membrane protein; Provisional; Region: PRK10995 1211025007300 putative arabinose transporter; Provisional; Region: PRK03545 1211025007301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025007302 putative substrate translocation pore; other site 1211025007303 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1211025007304 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1211025007305 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1211025007306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025007307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025007308 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1211025007309 putative dimerization interface [polypeptide binding]; other site 1211025007310 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1211025007311 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1211025007312 NAD(P) binding site [chemical binding]; other site 1211025007313 catalytic residues [active] 1211025007314 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1211025007315 dimer interface [polypeptide binding]; other site 1211025007316 ligand binding site [chemical binding]; other site 1211025007317 HAMP domain; Region: HAMP; pfam00672 1211025007318 dimerization interface [polypeptide binding]; other site 1211025007319 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1211025007320 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025007321 dimer interface [polypeptide binding]; other site 1211025007322 putative CheW interface [polypeptide binding]; other site 1211025007323 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1211025007324 glutaminase; Provisional; Region: PRK00971 1211025007325 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1211025007326 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025007327 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025007328 metal binding site [ion binding]; metal-binding site 1211025007329 active site 1211025007330 I-site; other site 1211025007331 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1211025007332 GAF domain; Region: GAF; pfam01590 1211025007333 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025007334 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025007335 metal binding site [ion binding]; metal-binding site 1211025007336 active site 1211025007337 I-site; other site 1211025007338 altronate oxidoreductase; Provisional; Region: PRK03643 1211025007339 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1211025007340 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1211025007341 Predicted membrane protein [Function unknown]; Region: COG3781 1211025007342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1211025007343 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1211025007344 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1211025007345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025007346 Coenzyme A binding pocket [chemical binding]; other site 1211025007347 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1211025007348 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1211025007349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025007350 active site 1211025007351 phosphorylation site [posttranslational modification] 1211025007352 intermolecular recognition site; other site 1211025007353 dimerization interface [polypeptide binding]; other site 1211025007354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025007355 DNA binding site [nucleotide binding] 1211025007356 HAMP domain; Region: HAMP; pfam00672 1211025007357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025007358 dimer interface [polypeptide binding]; other site 1211025007359 phosphorylation site [posttranslational modification] 1211025007360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025007361 ATP binding site [chemical binding]; other site 1211025007362 Mg2+ binding site [ion binding]; other site 1211025007363 G-X-G motif; other site 1211025007364 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1211025007365 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1211025007366 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1211025007367 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1211025007368 catalytic residues [active] 1211025007369 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1211025007370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025007371 S-adenosylmethionine binding site [chemical binding]; other site 1211025007372 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1211025007373 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1211025007374 dimer interface [polypeptide binding]; other site 1211025007375 ADP-ribose binding site [chemical binding]; other site 1211025007376 active site 1211025007377 nudix motif; other site 1211025007378 metal binding site [ion binding]; metal-binding site 1211025007379 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1211025007380 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1211025007381 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1211025007382 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1211025007383 Predicted membrane protein [Function unknown]; Region: COG4125 1211025007384 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1211025007385 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1211025007386 NACHT domain; Region: NACHT; pfam05729 1211025007387 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 1211025007388 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1211025007389 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1211025007390 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025007391 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1211025007392 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1211025007393 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1211025007394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025007395 active site 1211025007396 phosphorylation site [posttranslational modification] 1211025007397 intermolecular recognition site; other site 1211025007398 dimerization interface [polypeptide binding]; other site 1211025007399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025007400 DNA binding site [nucleotide binding] 1211025007401 sensor kinase CusS; Provisional; Region: PRK09835 1211025007402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025007403 dimerization interface [polypeptide binding]; other site 1211025007404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025007405 dimer interface [polypeptide binding]; other site 1211025007406 phosphorylation site [posttranslational modification] 1211025007407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025007408 ATP binding site [chemical binding]; other site 1211025007409 Mg2+ binding site [ion binding]; other site 1211025007410 G-X-G motif; other site 1211025007411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025007412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025007413 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1211025007414 putative substrate binding pocket [chemical binding]; other site 1211025007415 putative dimerization interface [polypeptide binding]; other site 1211025007416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025007417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025007418 putative substrate translocation pore; other site 1211025007419 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1211025007420 Predicted membrane protein [Function unknown]; Region: COG3817 1211025007421 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1211025007422 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1211025007423 MarR family; Region: MarR_2; cl17246 1211025007424 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1211025007425 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1211025007426 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1211025007427 active site 1211025007428 catalytic site [active] 1211025007429 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1211025007430 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1211025007431 active site 1211025007432 catalytic site [active] 1211025007433 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1211025007434 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1211025007435 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1211025007436 catalytic site [active] 1211025007437 active site 1211025007438 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1211025007439 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1211025007440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025007441 Coenzyme A binding pocket [chemical binding]; other site 1211025007442 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1211025007443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025007444 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1211025007445 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1211025007446 dimerization interface [polypeptide binding]; other site 1211025007447 substrate binding pocket [chemical binding]; other site 1211025007448 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1211025007449 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1211025007450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1211025007451 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1211025007452 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1211025007453 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1211025007454 dimerization domain [polypeptide binding]; other site 1211025007455 dimer interface [polypeptide binding]; other site 1211025007456 catalytic residues [active] 1211025007457 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1211025007458 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1211025007459 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1211025007460 catalytic residues [active] 1211025007461 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1211025007462 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1211025007463 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1211025007464 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1211025007465 DsbD alpha interface [polypeptide binding]; other site 1211025007466 catalytic residues [active] 1211025007467 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1211025007468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1211025007469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1211025007470 DNA binding residues [nucleotide binding] 1211025007471 RIB43A; Region: RIB43A; pfam05914 1211025007472 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1211025007473 ligand binding site [chemical binding]; other site 1211025007474 HAMP domain; Region: HAMP; pfam00672 1211025007475 dimerization interface [polypeptide binding]; other site 1211025007476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025007477 dimer interface [polypeptide binding]; other site 1211025007478 putative CheW interface [polypeptide binding]; other site 1211025007479 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1211025007480 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025007481 DNA binding site [nucleotide binding] 1211025007482 domain linker motif; other site 1211025007483 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1211025007484 dimerization interface [polypeptide binding]; other site 1211025007485 ligand binding site [chemical binding]; other site 1211025007486 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1211025007487 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1211025007488 substrate binding [chemical binding]; other site 1211025007489 active site 1211025007490 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1211025007491 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1211025007492 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025007493 active site turn [active] 1211025007494 phosphorylation site [posttranslational modification] 1211025007495 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1211025007496 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1211025007497 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1211025007498 trimer interface; other site 1211025007499 sugar binding site [chemical binding]; other site 1211025007500 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1211025007501 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1211025007502 putative substrate binding site [chemical binding]; other site 1211025007503 putative ATP binding site [chemical binding]; other site 1211025007504 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1211025007505 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025007506 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1211025007507 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1211025007508 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1211025007509 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1211025007510 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1211025007511 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1211025007512 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1211025007513 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1211025007514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025007515 dimer interface [polypeptide binding]; other site 1211025007516 conserved gate region; other site 1211025007517 putative PBP binding loops; other site 1211025007518 ABC-ATPase subunit interface; other site 1211025007519 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1211025007520 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1211025007521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025007522 dimer interface [polypeptide binding]; other site 1211025007523 conserved gate region; other site 1211025007524 putative PBP binding loops; other site 1211025007525 ABC-ATPase subunit interface; other site 1211025007526 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1211025007527 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025007528 Walker A/P-loop; other site 1211025007529 ATP binding site [chemical binding]; other site 1211025007530 Q-loop/lid; other site 1211025007531 ABC transporter signature motif; other site 1211025007532 Walker B; other site 1211025007533 D-loop; other site 1211025007534 H-loop/switch region; other site 1211025007535 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1211025007536 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1211025007537 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025007538 Walker A/P-loop; other site 1211025007539 ATP binding site [chemical binding]; other site 1211025007540 Q-loop/lid; other site 1211025007541 ABC transporter signature motif; other site 1211025007542 Walker B; other site 1211025007543 D-loop; other site 1211025007544 H-loop/switch region; other site 1211025007545 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1211025007546 short chain dehydrogenase; Provisional; Region: PRK06500 1211025007547 classical (c) SDRs; Region: SDR_c; cd05233 1211025007548 NAD(P) binding site [chemical binding]; other site 1211025007549 active site 1211025007550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025007551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025007552 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1211025007553 putative effector binding pocket; other site 1211025007554 putative dimerization interface [polypeptide binding]; other site 1211025007555 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1211025007556 transcriptional regulator; Provisional; Region: PRK10632 1211025007557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025007558 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1211025007559 putative effector binding pocket; other site 1211025007560 dimerization interface [polypeptide binding]; other site 1211025007561 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1211025007562 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 1211025007563 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1211025007564 malate dehydrogenase; Provisional; Region: PRK13529 1211025007565 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1211025007566 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1211025007567 NAD(P) binding site [chemical binding]; other site 1211025007568 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1211025007569 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025007570 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025007571 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1211025007572 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1211025007573 NAD binding site [chemical binding]; other site 1211025007574 substrate binding site [chemical binding]; other site 1211025007575 catalytic Zn binding site [ion binding]; other site 1211025007576 tetramer interface [polypeptide binding]; other site 1211025007577 structural Zn binding site [ion binding]; other site 1211025007578 MFS transport protein AraJ; Provisional; Region: PRK10091 1211025007579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025007580 putative substrate translocation pore; other site 1211025007581 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1211025007582 CcdB protein; Region: CcdB; cl03380 1211025007583 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1211025007584 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1211025007585 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1211025007586 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1211025007587 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025007588 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025007589 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1211025007590 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1211025007591 molybdopterin cofactor binding site; other site 1211025007592 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025007593 aromatic amino acid exporter; Provisional; Region: PRK11689 1211025007594 EamA-like transporter family; Region: EamA; pfam00892 1211025007595 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1211025007596 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1211025007597 trimer interface [polypeptide binding]; other site 1211025007598 eyelet of channel; other site 1211025007599 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1211025007600 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1211025007601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025007602 putative substrate translocation pore; other site 1211025007603 TetR family transcriptional regulator; Provisional; Region: PRK14996 1211025007604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025007605 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1211025007606 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1211025007607 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1211025007608 [4Fe-4S] binding site [ion binding]; other site 1211025007609 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025007610 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025007611 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025007612 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1211025007613 molybdopterin cofactor binding site; other site 1211025007614 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1211025007615 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1211025007616 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1211025007617 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1211025007618 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1211025007619 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1211025007620 potential frameshift: common BLAST hit: gi|296102243|ref|YP_003612389.1| translation elongation factor 2 (EF-2/EF-G) 1211025007621 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1211025007622 dimerization interface [polypeptide binding]; other site 1211025007623 putative DNA binding site [nucleotide binding]; other site 1211025007624 putative Zn2+ binding site [ion binding]; other site 1211025007625 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1211025007626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025007627 Coenzyme A binding pocket [chemical binding]; other site 1211025007628 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1211025007629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025007630 DNA-binding site [nucleotide binding]; DNA binding site 1211025007631 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025007632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025007633 homodimer interface [polypeptide binding]; other site 1211025007634 catalytic residue [active] 1211025007635 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1211025007636 putative acyl-acceptor binding pocket; other site 1211025007637 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 1211025007638 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1211025007639 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1211025007640 C-terminal domain interface [polypeptide binding]; other site 1211025007641 GSH binding site (G-site) [chemical binding]; other site 1211025007642 dimer interface [polypeptide binding]; other site 1211025007643 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1211025007644 N-terminal domain interface [polypeptide binding]; other site 1211025007645 dimer interface [polypeptide binding]; other site 1211025007646 substrate binding pocket (H-site) [chemical binding]; other site 1211025007647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025007648 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1211025007649 substrate binding pocket [chemical binding]; other site 1211025007650 membrane-bound complex binding site; other site 1211025007651 hinge residues; other site 1211025007652 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1211025007653 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1211025007654 Walker A/P-loop; other site 1211025007655 ATP binding site [chemical binding]; other site 1211025007656 Q-loop/lid; other site 1211025007657 ABC transporter signature motif; other site 1211025007658 Walker B; other site 1211025007659 D-loop; other site 1211025007660 H-loop/switch region; other site 1211025007661 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1211025007662 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1211025007663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025007664 dimer interface [polypeptide binding]; other site 1211025007665 conserved gate region; other site 1211025007666 putative PBP binding loops; other site 1211025007667 ABC-ATPase subunit interface; other site 1211025007668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025007669 Coenzyme A binding pocket [chemical binding]; other site 1211025007670 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1211025007671 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025007672 substrate binding pocket [chemical binding]; other site 1211025007673 membrane-bound complex binding site; other site 1211025007674 hinge residues; other site 1211025007675 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1211025007676 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1211025007677 active site 1211025007678 non-prolyl cis peptide bond; other site 1211025007679 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1211025007680 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1211025007681 metal binding site [ion binding]; metal-binding site 1211025007682 dimer interface [polypeptide binding]; other site 1211025007683 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1211025007684 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1211025007685 AAA domain; Region: AAA_17; pfam13207 1211025007686 L-asparagine permease; Provisional; Region: PRK15049 1211025007687 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1211025007688 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1211025007689 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1211025007690 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025007691 N-terminal plug; other site 1211025007692 ligand-binding site [chemical binding]; other site 1211025007693 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1211025007694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025007695 DNA-binding site [nucleotide binding]; DNA binding site 1211025007696 FCD domain; Region: FCD; pfam07729 1211025007697 potential frameshift: common BLAST hit: gi|365970682|ref|YP_004952243.1| putative NADP-dependent oxidoreductase yncB 1211025007698 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1211025007699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025007700 non-specific DNA binding site [nucleotide binding]; other site 1211025007701 salt bridge; other site 1211025007702 sequence-specific DNA binding site [nucleotide binding]; other site 1211025007703 Cupin domain; Region: Cupin_2; pfam07883 1211025007704 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1211025007705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025007706 Coenzyme A binding pocket [chemical binding]; other site 1211025007707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1211025007708 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1211025007709 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1211025007710 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1211025007711 peptide binding site [polypeptide binding]; other site 1211025007712 Virulence factor SrfB; Region: SrfB; pfam07520 1211025007713 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1211025007714 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1211025007715 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1211025007716 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1211025007717 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1211025007718 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1211025007719 tetrameric interface [polypeptide binding]; other site 1211025007720 NAD binding site [chemical binding]; other site 1211025007721 catalytic residues [active] 1211025007722 substrate binding site [chemical binding]; other site 1211025007723 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1211025007724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025007725 dimer interface [polypeptide binding]; other site 1211025007726 conserved gate region; other site 1211025007727 putative PBP binding loops; other site 1211025007728 ABC-ATPase subunit interface; other site 1211025007729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025007730 dimer interface [polypeptide binding]; other site 1211025007731 conserved gate region; other site 1211025007732 putative PBP binding loops; other site 1211025007733 ABC-ATPase subunit interface; other site 1211025007734 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1211025007735 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025007736 Walker A/P-loop; other site 1211025007737 ATP binding site [chemical binding]; other site 1211025007738 Q-loop/lid; other site 1211025007739 ABC transporter signature motif; other site 1211025007740 Walker B; other site 1211025007741 D-loop; other site 1211025007742 H-loop/switch region; other site 1211025007743 TOBE domain; Region: TOBE_2; pfam08402 1211025007744 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1211025007745 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1211025007746 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1211025007747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025007748 DNA-binding site [nucleotide binding]; DNA binding site 1211025007749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025007750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025007751 homodimer interface [polypeptide binding]; other site 1211025007752 catalytic residue [active] 1211025007753 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1211025007754 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1211025007755 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1211025007756 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1211025007757 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1211025007758 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1211025007759 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1211025007760 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1211025007761 heat-inducible protein; Provisional; Region: PRK10449 1211025007762 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1211025007763 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1211025007764 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1211025007765 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1211025007766 dimer interface [polypeptide binding]; other site 1211025007767 PYR/PP interface [polypeptide binding]; other site 1211025007768 TPP binding site [chemical binding]; other site 1211025007769 substrate binding site [chemical binding]; other site 1211025007770 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1211025007771 Domain of unknown function; Region: EKR; pfam10371 1211025007772 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1211025007773 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1211025007774 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1211025007775 TPP-binding site [chemical binding]; other site 1211025007776 dimer interface [polypeptide binding]; other site 1211025007777 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1211025007778 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1211025007779 trimer interface [polypeptide binding]; other site 1211025007780 eyelet of channel; other site 1211025007781 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1211025007782 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1211025007783 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1211025007784 active site 1211025007785 metal binding site [ion binding]; metal-binding site 1211025007786 Predicted membrane protein [Function unknown]; Region: COG3326 1211025007787 hypothetical protein; Provisional; Region: PRK09951 1211025007788 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1211025007789 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1211025007790 active site 1211025007791 DNA binding site [nucleotide binding] 1211025007792 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1211025007793 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1211025007794 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1211025007795 Catalytic site [active] 1211025007796 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1211025007797 Phage-related protein, tail component [Function unknown]; Region: COG4733 1211025007798 NlpC/P60 family; Region: NLPC_P60; cl17555 1211025007799 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1211025007800 Phage-related minor tail protein [Function unknown]; Region: COG5281 1211025007801 tape measure domain; Region: tape_meas_nterm; TIGR02675 1211025007802 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1211025007803 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1211025007804 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1211025007805 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1211025007806 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 1211025007807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1211025007808 Terminase-like family; Region: Terminase_6; pfam03237 1211025007809 Uncharacterized conserved protein [Function unknown]; Region: COG5323 1211025007810 Terminase small subunit; Region: Terminase_2; pfam03592 1211025007811 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1211025007812 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1211025007813 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1211025007814 catalytic residues [active] 1211025007815 Lysis protein S; Region: Lysis_S; pfam04971 1211025007816 Antitermination protein; Region: Antiterm; pfam03589 1211025007817 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1211025007818 Antitermination protein; Region: Antiterm; pfam03589 1211025007819 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1211025007820 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1211025007821 DinI-like family; Region: DinI; cl11630 1211025007822 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1211025007823 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1211025007824 active site 1211025007825 metal binding site [ion binding]; metal-binding site 1211025007826 Sensors of blue-light using FAD; Region: BLUF; smart01034 1211025007827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025007828 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1211025007829 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1211025007830 Replication protein P; Region: Phage_lambda_P; pfam06992 1211025007831 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1211025007832 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1211025007833 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1211025007834 transcriptional repressor DicA; Reviewed; Region: PRK09706 1211025007835 non-specific DNA binding site [nucleotide binding]; other site 1211025007836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1211025007837 sequence-specific DNA binding site [nucleotide binding]; other site 1211025007838 salt bridge; other site 1211025007839 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1211025007840 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 1211025007841 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 1211025007842 RecT family; Region: RecT; pfam03837 1211025007843 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 1211025007844 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1211025007845 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1211025007846 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1211025007847 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1211025007848 Int/Topo IB signature motif; other site 1211025007849 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1211025007850 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1211025007851 Ligand Binding Site [chemical binding]; other site 1211025007852 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1211025007853 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1211025007854 ATP binding site [chemical binding]; other site 1211025007855 Mg++ binding site [ion binding]; other site 1211025007856 motif III; other site 1211025007857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025007858 nucleotide binding region [chemical binding]; other site 1211025007859 ATP-binding site [chemical binding]; other site 1211025007860 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1211025007861 putative RNA binding site [nucleotide binding]; other site 1211025007862 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1211025007863 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1211025007864 Cl binding site [ion binding]; other site 1211025007865 oligomer interface [polypeptide binding]; other site 1211025007866 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1211025007867 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025007868 dimer interface [polypeptide binding]; other site 1211025007869 putative CheW interface [polypeptide binding]; other site 1211025007870 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1211025007871 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1211025007872 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1211025007873 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025007874 metal binding site [ion binding]; metal-binding site 1211025007875 active site 1211025007876 I-site; other site 1211025007877 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025007878 PAS domain S-box; Region: sensory_box; TIGR00229 1211025007879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025007880 putative active site [active] 1211025007881 heme pocket [chemical binding]; other site 1211025007882 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025007883 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025007884 metal binding site [ion binding]; metal-binding site 1211025007885 active site 1211025007886 I-site; other site 1211025007887 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1211025007888 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1211025007889 conserved cys residue [active] 1211025007890 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1211025007891 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1211025007892 peptide binding site [polypeptide binding]; other site 1211025007893 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1211025007894 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1211025007895 putative active site [active] 1211025007896 Zn binding site [ion binding]; other site 1211025007897 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1211025007898 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1211025007899 active site 1211025007900 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1211025007901 dimer interface [polypeptide binding]; other site 1211025007902 catalytic triad [active] 1211025007903 peroxidatic and resolving cysteines [active] 1211025007904 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1211025007905 active site 1211025007906 catalytic residues [active] 1211025007907 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1211025007908 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1211025007909 PAS domain; Region: PAS; smart00091 1211025007910 putative active site [active] 1211025007911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025007912 Walker A motif; other site 1211025007913 ATP binding site [chemical binding]; other site 1211025007914 Walker B motif; other site 1211025007915 arginine finger; other site 1211025007916 hypothetical protein; Provisional; Region: PRK05415 1211025007917 Domain of unknown function (DUF697); Region: DUF697; cl12064 1211025007918 Predicted ATPase [General function prediction only]; Region: COG3106 1211025007919 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025007920 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025007921 DNA binding site [nucleotide binding] 1211025007922 domain linker motif; other site 1211025007923 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1211025007924 putative dimerization interface [polypeptide binding]; other site 1211025007925 putative ligand binding site [chemical binding]; other site 1211025007926 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 1211025007927 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1211025007928 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1211025007929 Walker A/P-loop; other site 1211025007930 ATP binding site [chemical binding]; other site 1211025007931 Q-loop/lid; other site 1211025007932 ABC transporter signature motif; other site 1211025007933 Walker B; other site 1211025007934 D-loop; other site 1211025007935 H-loop/switch region; other site 1211025007936 TOBE domain; Region: TOBE_2; pfam08402 1211025007937 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1211025007938 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1211025007939 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1211025007940 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1211025007941 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1211025007942 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1211025007943 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025007944 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025007945 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1211025007946 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1211025007947 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1211025007948 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1211025007949 putative NAD(P) binding site [chemical binding]; other site 1211025007950 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1211025007951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025007952 dimer interface [polypeptide binding]; other site 1211025007953 conserved gate region; other site 1211025007954 putative PBP binding loops; other site 1211025007955 ABC-ATPase subunit interface; other site 1211025007956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025007957 dimer interface [polypeptide binding]; other site 1211025007958 conserved gate region; other site 1211025007959 putative PBP binding loops; other site 1211025007960 ABC-ATPase subunit interface; other site 1211025007961 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1211025007962 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1211025007963 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1211025007964 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1211025007965 active site 1211025007966 homodimer interface [polypeptide binding]; other site 1211025007967 catalytic site [active] 1211025007968 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1211025007969 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1211025007970 phage shock protein C; Region: phageshock_pspC; TIGR02978 1211025007971 phage shock protein B; Provisional; Region: pspB; PRK09458 1211025007972 phage shock protein PspA; Provisional; Region: PRK10698 1211025007973 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1211025007974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025007975 Walker A motif; other site 1211025007976 ATP binding site [chemical binding]; other site 1211025007977 Walker B motif; other site 1211025007978 arginine finger; other site 1211025007979 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1211025007980 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1211025007981 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1211025007982 peptide binding site [polypeptide binding]; other site 1211025007983 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1211025007984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025007985 dimer interface [polypeptide binding]; other site 1211025007986 conserved gate region; other site 1211025007987 putative PBP binding loops; other site 1211025007988 ABC-ATPase subunit interface; other site 1211025007989 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1211025007990 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1211025007991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025007992 dimer interface [polypeptide binding]; other site 1211025007993 conserved gate region; other site 1211025007994 putative PBP binding loops; other site 1211025007995 ABC-ATPase subunit interface; other site 1211025007996 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1211025007997 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025007998 Walker A/P-loop; other site 1211025007999 ATP binding site [chemical binding]; other site 1211025008000 Q-loop/lid; other site 1211025008001 ABC transporter signature motif; other site 1211025008002 Walker B; other site 1211025008003 D-loop; other site 1211025008004 H-loop/switch region; other site 1211025008005 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1211025008006 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1211025008007 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025008008 Walker A/P-loop; other site 1211025008009 ATP binding site [chemical binding]; other site 1211025008010 Q-loop/lid; other site 1211025008011 ABC transporter signature motif; other site 1211025008012 Walker B; other site 1211025008013 D-loop; other site 1211025008014 H-loop/switch region; other site 1211025008015 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1211025008016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1211025008017 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025008018 dimerization interface [polypeptide binding]; other site 1211025008019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025008020 dimer interface [polypeptide binding]; other site 1211025008021 phosphorylation site [posttranslational modification] 1211025008022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025008023 ATP binding site [chemical binding]; other site 1211025008024 Mg2+ binding site [ion binding]; other site 1211025008025 G-X-G motif; other site 1211025008026 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1211025008027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025008028 active site 1211025008029 phosphorylation site [posttranslational modification] 1211025008030 intermolecular recognition site; other site 1211025008031 dimerization interface [polypeptide binding]; other site 1211025008032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025008033 DNA binding site [nucleotide binding] 1211025008034 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 1211025008035 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1211025008036 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1211025008037 Protein export membrane protein; Region: SecD_SecF; cl14618 1211025008038 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1211025008039 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1211025008040 NAD binding site [chemical binding]; other site 1211025008041 homotetramer interface [polypeptide binding]; other site 1211025008042 homodimer interface [polypeptide binding]; other site 1211025008043 substrate binding site [chemical binding]; other site 1211025008044 active site 1211025008045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1211025008046 exoribonuclease II; Provisional; Region: PRK05054 1211025008047 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1211025008048 RNB domain; Region: RNB; pfam00773 1211025008049 S1 RNA binding domain; Region: S1; pfam00575 1211025008050 RNase II stability modulator; Provisional; Region: PRK10060 1211025008051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025008052 putative active site [active] 1211025008053 heme pocket [chemical binding]; other site 1211025008054 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025008055 metal binding site [ion binding]; metal-binding site 1211025008056 active site 1211025008057 I-site; other site 1211025008058 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025008059 enoyl-CoA hydratase; Validated; Region: PRK08788 1211025008060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1211025008061 substrate binding site [chemical binding]; other site 1211025008062 oxyanion hole (OAH) forming residues; other site 1211025008063 trimer interface [polypeptide binding]; other site 1211025008064 hypothetical protein; Provisional; Region: PRK13658 1211025008065 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1211025008066 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1211025008067 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1211025008068 lipoprotein; Provisional; Region: PRK10540 1211025008069 translation initiation factor Sui1; Validated; Region: PRK06824 1211025008070 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1211025008071 putative rRNA binding site [nucleotide binding]; other site 1211025008072 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1211025008073 active site 1211025008074 dimer interface [polypeptide binding]; other site 1211025008075 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1211025008076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1211025008077 TPR motif; other site 1211025008078 binding surface 1211025008079 Predicted membrane protein [Function unknown]; Region: COG3771 1211025008080 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1211025008081 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1211025008082 active site 1211025008083 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1211025008084 dimerization interface [polypeptide binding]; other site 1211025008085 active site 1211025008086 aconitate hydratase; Validated; Region: PRK09277 1211025008087 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1211025008088 substrate binding site [chemical binding]; other site 1211025008089 ligand binding site [chemical binding]; other site 1211025008090 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1211025008091 substrate binding site [chemical binding]; other site 1211025008092 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1211025008093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025008094 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1211025008095 substrate binding site [chemical binding]; other site 1211025008096 putative dimerization interface [polypeptide binding]; other site 1211025008097 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1211025008098 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1211025008099 active site 1211025008100 interdomain interaction site; other site 1211025008101 putative metal-binding site [ion binding]; other site 1211025008102 nucleotide binding site [chemical binding]; other site 1211025008103 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1211025008104 domain I; other site 1211025008105 DNA binding groove [nucleotide binding] 1211025008106 phosphate binding site [ion binding]; other site 1211025008107 domain II; other site 1211025008108 domain III; other site 1211025008109 nucleotide binding site [chemical binding]; other site 1211025008110 catalytic site [active] 1211025008111 domain IV; other site 1211025008112 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1211025008113 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1211025008114 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1211025008115 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1211025008116 hypothetical protein; Provisional; Region: PRK11037 1211025008117 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1211025008118 putative inner membrane peptidase; Provisional; Region: PRK11778 1211025008119 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1211025008120 tandem repeat interface [polypeptide binding]; other site 1211025008121 oligomer interface [polypeptide binding]; other site 1211025008122 active site residues [active] 1211025008123 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1211025008124 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1211025008125 NADP binding site [chemical binding]; other site 1211025008126 homodimer interface [polypeptide binding]; other site 1211025008127 active site 1211025008128 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1211025008129 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 1211025008130 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1211025008131 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1211025008132 RNA binding surface [nucleotide binding]; other site 1211025008133 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1211025008134 probable active site [active] 1211025008135 hypothetical protein; Provisional; Region: PRK11630 1211025008136 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1211025008137 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1211025008138 active site 1211025008139 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1211025008140 anthranilate synthase component I; Provisional; Region: PRK13564 1211025008141 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1211025008142 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1211025008143 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1211025008144 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1211025008145 glutamine binding [chemical binding]; other site 1211025008146 catalytic triad [active] 1211025008147 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1211025008148 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1211025008149 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1211025008150 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1211025008151 active site 1211025008152 ribulose/triose binding site [chemical binding]; other site 1211025008153 phosphate binding site [ion binding]; other site 1211025008154 substrate (anthranilate) binding pocket [chemical binding]; other site 1211025008155 product (indole) binding pocket [chemical binding]; other site 1211025008156 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1211025008157 active site 1211025008158 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1211025008159 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1211025008160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025008161 catalytic residue [active] 1211025008162 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1211025008163 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1211025008164 substrate binding site [chemical binding]; other site 1211025008165 active site 1211025008166 catalytic residues [active] 1211025008167 heterodimer interface [polypeptide binding]; other site 1211025008168 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1211025008169 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1211025008170 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1211025008171 DNA-binding site [nucleotide binding]; DNA binding site 1211025008172 RNA-binding motif; other site 1211025008173 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1211025008174 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1211025008175 catalytic residues [active] 1211025008176 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1211025008177 MarR family; Region: MarR; pfam01047 1211025008178 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1211025008179 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1211025008180 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1211025008181 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1211025008182 nucleophilic elbow; other site 1211025008183 catalytic triad; other site 1211025008184 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1211025008185 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1211025008186 putative NAD(P) binding site [chemical binding]; other site 1211025008187 potential frameshift: common BLAST hit: gi|365970857|ref|YP_004952418.1| UcpA 1211025008188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1211025008189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025008190 putative inner membrane protein; Provisional; Region: PRK11099 1211025008191 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1211025008192 CPxP motif; other site 1211025008193 outer membrane protein W; Provisional; Region: PRK10959 1211025008194 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1211025008195 hypothetical protein; Provisional; Region: PRK02868 1211025008196 intracellular septation protein A; Reviewed; Region: PRK00259 1211025008197 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1211025008198 transport protein TonB; Provisional; Region: PRK10819 1211025008199 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1211025008200 YciI-like protein; Reviewed; Region: PRK11370 1211025008201 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1211025008202 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1211025008203 tail protein; Provisional; Region: D; PHA02561 1211025008204 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1211025008205 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1211025008206 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1211025008207 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1211025008208 major tail tube protein; Provisional; Region: FII; PHA02600 1211025008209 major tail sheath protein; Provisional; Region: FI; PHA02560 1211025008210 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1211025008211 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1211025008212 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1211025008213 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 1211025008214 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 1211025008215 baseplate assembly protein; Provisional; Region: J; PHA02568 1211025008216 baseplate wedge subunit; Provisional; Region: W; PHA02516 1211025008217 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1211025008218 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1211025008219 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 1211025008220 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1211025008221 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1211025008222 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1211025008223 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1211025008224 catalytic residues [active] 1211025008225 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1211025008226 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1211025008227 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1211025008228 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1211025008229 capsid protein; Provisional; Region: N; PHA02538 1211025008230 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 1211025008231 terminase ATPase subunit; Provisional; Region: P; PHA02535 1211025008232 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1211025008233 portal vertex protein; Provisional; Region: Q; PHA02536 1211025008234 Phage portal protein; Region: Phage_portal; pfam04860 1211025008235 potential frameshift: common BLAST hit: gi|308186459|ref|YP_003930590.1| spermidine/putrescine import ATP-binding protein potA 1211025008236 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1211025008237 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1211025008238 putative active site [active] 1211025008239 putative NTP binding site [chemical binding]; other site 1211025008240 putative nucleic acid binding site [nucleotide binding]; other site 1211025008241 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1211025008242 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1211025008243 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 1211025008244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025008245 non-specific DNA binding site [nucleotide binding]; other site 1211025008246 salt bridge; other site 1211025008247 sequence-specific DNA binding site [nucleotide binding]; other site 1211025008248 integrase; Provisional; Region: int; PHA02601 1211025008249 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1211025008250 active site 1211025008251 DNA binding site [nucleotide binding] 1211025008252 Int/Topo IB signature motif; other site 1211025008253 leucine export protein LeuE; Provisional; Region: PRK10958 1211025008254 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1211025008255 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1211025008256 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1211025008257 putative active site [active] 1211025008258 catalytic site [active] 1211025008259 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1211025008260 putative active site [active] 1211025008261 catalytic site [active] 1211025008262 dsDNA-mimic protein; Reviewed; Region: PRK05094 1211025008263 Ion transport protein; Region: Ion_trans; pfam00520 1211025008264 Ion channel; Region: Ion_trans_2; pfam07885 1211025008265 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1211025008266 Double zinc ribbon; Region: DZR; pfam12773 1211025008267 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1211025008268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025008269 Walker A/P-loop; other site 1211025008270 ATP binding site [chemical binding]; other site 1211025008271 Q-loop/lid; other site 1211025008272 ABC transporter signature motif; other site 1211025008273 Walker B; other site 1211025008274 D-loop; other site 1211025008275 H-loop/switch region; other site 1211025008276 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1211025008277 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1211025008278 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025008279 Walker A/P-loop; other site 1211025008280 ATP binding site [chemical binding]; other site 1211025008281 Q-loop/lid; other site 1211025008282 ABC transporter signature motif; other site 1211025008283 Walker B; other site 1211025008284 D-loop; other site 1211025008285 H-loop/switch region; other site 1211025008286 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1211025008287 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1211025008288 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1211025008289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025008290 dimer interface [polypeptide binding]; other site 1211025008291 conserved gate region; other site 1211025008292 putative PBP binding loops; other site 1211025008293 ABC-ATPase subunit interface; other site 1211025008294 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1211025008295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025008296 dimer interface [polypeptide binding]; other site 1211025008297 conserved gate region; other site 1211025008298 putative PBP binding loops; other site 1211025008299 ABC-ATPase subunit interface; other site 1211025008300 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1211025008301 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1211025008302 peptide binding site [polypeptide binding]; other site 1211025008303 hypothetical protein; Provisional; Region: PRK11111 1211025008304 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1211025008305 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1211025008306 putative catalytic cysteine [active] 1211025008307 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1211025008308 putative active site [active] 1211025008309 metal binding site [ion binding]; metal-binding site 1211025008310 thymidine kinase; Provisional; Region: PRK04296 1211025008311 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1211025008312 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1211025008313 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1211025008314 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1211025008315 active site 1211025008316 tetramer interface; other site 1211025008317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025008318 active site 1211025008319 response regulator of RpoS; Provisional; Region: PRK10693 1211025008320 phosphorylation site [posttranslational modification] 1211025008321 intermolecular recognition site; other site 1211025008322 dimerization interface [polypeptide binding]; other site 1211025008323 hypothetical protein; Provisional; Region: PRK10279 1211025008324 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1211025008325 active site 1211025008326 nucleophile elbow; other site 1211025008327 SEC-C motif; Region: SEC-C; pfam02810 1211025008328 hypothetical protein; Provisional; Region: PRK04233 1211025008329 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1211025008330 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1211025008331 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1211025008332 putative active site [active] 1211025008333 putative substrate binding site [chemical binding]; other site 1211025008334 putative cosubstrate binding site; other site 1211025008335 catalytic site [active] 1211025008336 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1211025008337 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1211025008338 AsnC family; Region: AsnC_trans_reg; pfam01037 1211025008339 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1211025008340 EamA-like transporter family; Region: EamA; pfam00892 1211025008341 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1211025008342 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1211025008343 potential frameshift: common BLAST hit: gi|296101984|ref|YP_003612130.1| nitrate reductase 1 subunit beta 1211025008344 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1211025008345 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1211025008346 [4Fe-4S] binding site [ion binding]; other site 1211025008347 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025008348 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025008349 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025008350 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1211025008351 molybdopterin cofactor binding site; other site 1211025008352 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1211025008353 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1211025008354 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1211025008355 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025008356 dimerization interface [polypeptide binding]; other site 1211025008357 Histidine kinase; Region: HisKA_3; pfam07730 1211025008358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025008359 ATP binding site [chemical binding]; other site 1211025008360 Mg2+ binding site [ion binding]; other site 1211025008361 G-X-G motif; other site 1211025008362 transcriptional regulator NarL; Provisional; Region: PRK10651 1211025008363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025008364 active site 1211025008365 phosphorylation site [posttranslational modification] 1211025008366 intermolecular recognition site; other site 1211025008367 dimerization interface [polypeptide binding]; other site 1211025008368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025008369 DNA binding residues [nucleotide binding] 1211025008370 dimerization interface [polypeptide binding]; other site 1211025008371 putative invasin; Provisional; Region: PRK10177 1211025008372 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1211025008373 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1211025008374 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1211025008375 [4Fe-4S] binding site [ion binding]; other site 1211025008376 molybdopterin cofactor binding site; other site 1211025008377 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1211025008378 molybdopterin cofactor binding site; other site 1211025008379 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1211025008380 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1211025008381 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1211025008382 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025008383 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1211025008384 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1211025008385 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1211025008386 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1211025008387 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1211025008388 Walker A/P-loop; other site 1211025008389 ATP binding site [chemical binding]; other site 1211025008390 Q-loop/lid; other site 1211025008391 ABC transporter signature motif; other site 1211025008392 Walker B; other site 1211025008393 D-loop; other site 1211025008394 H-loop/switch region; other site 1211025008395 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1211025008396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025008397 dimer interface [polypeptide binding]; other site 1211025008398 conserved gate region; other site 1211025008399 putative PBP binding loops; other site 1211025008400 ABC-ATPase subunit interface; other site 1211025008401 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1211025008402 NMT1-like family; Region: NMT1_2; pfam13379 1211025008403 Nitrate and nitrite sensing; Region: NIT; pfam08376 1211025008404 ANTAR domain; Region: ANTAR; pfam03861 1211025008405 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1211025008406 Cache domain; Region: Cache_1; pfam02743 1211025008407 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025008408 dimerization interface [polypeptide binding]; other site 1211025008409 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1211025008410 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025008411 dimer interface [polypeptide binding]; other site 1211025008412 putative CheW interface [polypeptide binding]; other site 1211025008413 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1211025008414 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1211025008415 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1211025008416 putative active site pocket [active] 1211025008417 dimerization interface [polypeptide binding]; other site 1211025008418 putative catalytic residue [active] 1211025008419 cation transport regulator; Reviewed; Region: chaB; PRK09582 1211025008420 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1211025008421 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1211025008422 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1211025008423 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1211025008424 hypothetical protein; Provisional; Region: PRK10941 1211025008425 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1211025008426 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1211025008427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025008428 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1211025008429 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1211025008430 RF-1 domain; Region: RF-1; pfam00472 1211025008431 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1211025008432 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1211025008433 tRNA; other site 1211025008434 putative tRNA binding site [nucleotide binding]; other site 1211025008435 putative NADP binding site [chemical binding]; other site 1211025008436 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1211025008437 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1211025008438 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1211025008439 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1211025008440 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1211025008441 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1211025008442 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1211025008443 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1211025008444 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1211025008445 active site 1211025008446 putative transporter; Provisional; Region: PRK11660 1211025008447 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1211025008448 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1211025008449 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1211025008450 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1211025008451 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1211025008452 DNA binding residues [nucleotide binding] 1211025008453 putative dimer interface [polypeptide binding]; other site 1211025008454 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1211025008455 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1211025008456 hypothetical protein; Provisional; Region: PRK10692 1211025008457 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1211025008458 putative active site [active] 1211025008459 catalytic residue [active] 1211025008460 GTP-binding protein YchF; Reviewed; Region: PRK09601 1211025008461 YchF GTPase; Region: YchF; cd01900 1211025008462 G1 box; other site 1211025008463 GTP/Mg2+ binding site [chemical binding]; other site 1211025008464 Switch I region; other site 1211025008465 G2 box; other site 1211025008466 Switch II region; other site 1211025008467 G3 box; other site 1211025008468 G4 box; other site 1211025008469 G5 box; other site 1211025008470 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1211025008471 YCII-related domain; Region: YCII; cl00999 1211025008472 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1211025008473 RHS protein; Region: RHS; pfam03527 1211025008474 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1211025008475 PAAR motif; Region: PAAR_motif; pfam05488 1211025008476 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1211025008477 RHS Repeat; Region: RHS_repeat; pfam05593 1211025008478 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1211025008479 RHS Repeat; Region: RHS_repeat; pfam05593 1211025008480 RHS Repeat; Region: RHS_repeat; pfam05593 1211025008481 RHS Repeat; Region: RHS_repeat; cl11982 1211025008482 RHS Repeat; Region: RHS_repeat; pfam05593 1211025008483 RHS Repeat; Region: RHS_repeat; pfam05593 1211025008484 RHS protein; Region: RHS; pfam03527 1211025008485 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1211025008486 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1211025008487 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1211025008488 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1211025008489 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1211025008490 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1211025008491 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1211025008492 active site 1211025008493 ATP binding site [chemical binding]; other site 1211025008494 substrate binding site [chemical binding]; other site 1211025008495 activation loop (A-loop); other site 1211025008496 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1211025008497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025008498 Walker A motif; other site 1211025008499 ATP binding site [chemical binding]; other site 1211025008500 Walker B motif; other site 1211025008501 arginine finger; other site 1211025008502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025008503 Walker A motif; other site 1211025008504 ATP binding site [chemical binding]; other site 1211025008505 Walker B motif; other site 1211025008506 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1211025008507 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1211025008508 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1211025008509 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1211025008510 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1211025008511 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1211025008512 ImpE protein; Region: ImpE; pfam07024 1211025008513 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1211025008514 active site 1211025008515 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1211025008516 phosphopeptide binding site; other site 1211025008517 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1211025008518 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1211025008519 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1211025008520 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1211025008521 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1211025008522 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1211025008523 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1211025008524 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1211025008525 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1211025008526 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1211025008527 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1211025008528 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1211025008529 hypothetical protein; Provisional; Region: PRK07033 1211025008530 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1211025008531 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1211025008532 ligand binding site [chemical binding]; other site 1211025008533 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1211025008534 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1211025008535 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1211025008536 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1211025008537 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1211025008538 putative molybdopterin cofactor binding site [chemical binding]; other site 1211025008539 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1211025008540 putative molybdopterin cofactor binding site; other site 1211025008541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025008542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025008543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1211025008544 dimerization interface [polypeptide binding]; other site 1211025008545 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1211025008546 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1211025008547 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1211025008548 putative di-iron ligands [ion binding]; other site 1211025008549 potential frameshift: common BLAST hit: gi|365970996|ref|YP_004952557.1| HTH-type transcriptional regulator glxA 1211025008550 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1211025008551 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1211025008552 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1211025008553 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1211025008554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025008555 putative substrate translocation pore; other site 1211025008556 Cupin; Region: Cupin_6; pfam12852 1211025008557 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1211025008558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025008559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025008560 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 1211025008561 trehalase; Provisional; Region: treA; PRK13271 1211025008562 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1211025008563 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1211025008564 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025008565 N-terminal plug; other site 1211025008566 ligand-binding site [chemical binding]; other site 1211025008567 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1211025008568 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1211025008569 Flagellar regulator YcgR; Region: YcgR; pfam07317 1211025008570 PilZ domain; Region: PilZ; pfam07238 1211025008571 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1211025008572 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1211025008573 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1211025008574 catalytic residue [active] 1211025008575 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1211025008576 dimer interface [polypeptide binding]; other site 1211025008577 catalytic triad [active] 1211025008578 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1211025008579 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1211025008580 TrkA-C domain; Region: TrkA_C; pfam02080 1211025008581 Transporter associated domain; Region: CorC_HlyC; smart01091 1211025008582 alanine racemase; Reviewed; Region: dadX; PRK03646 1211025008583 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1211025008584 active site 1211025008585 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1211025008586 substrate binding site [chemical binding]; other site 1211025008587 catalytic residues [active] 1211025008588 dimer interface [polypeptide binding]; other site 1211025008589 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1211025008590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025008591 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1211025008592 SpoVR family protein; Provisional; Region: PRK11767 1211025008593 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1211025008594 fatty acid metabolism regulator; Provisional; Region: PRK04984 1211025008595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025008596 DNA-binding site [nucleotide binding]; DNA binding site 1211025008597 FadR C-terminal domain; Region: FadR_C; pfam07840 1211025008598 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1211025008599 transmembrane helices; other site 1211025008600 disulfide bond formation protein B; Provisional; Region: PRK01749 1211025008601 hypothetical protein; Provisional; Region: PRK05170 1211025008602 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1211025008603 hypothetical protein; Provisional; Region: PRK10691 1211025008604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1211025008605 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1211025008606 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1211025008607 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1211025008608 cell division inhibitor MinD; Provisional; Region: PRK10818 1211025008609 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1211025008610 Switch I; other site 1211025008611 Switch II; other site 1211025008612 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1211025008613 ribonuclease D; Provisional; Region: PRK10829 1211025008614 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1211025008615 catalytic site [active] 1211025008616 putative active site [active] 1211025008617 putative substrate binding site [chemical binding]; other site 1211025008618 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1211025008619 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1211025008620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1211025008621 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1211025008622 acyl-activating enzyme (AAE) consensus motif; other site 1211025008623 putative AMP binding site [chemical binding]; other site 1211025008624 putative active site [active] 1211025008625 putative CoA binding site [chemical binding]; other site 1211025008626 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1211025008627 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1211025008628 Glycoprotease family; Region: Peptidase_M22; pfam00814 1211025008629 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1211025008630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1211025008631 ATP binding site [chemical binding]; other site 1211025008632 DEAD_2; Region: DEAD_2; pfam06733 1211025008633 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1211025008634 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1211025008635 homotrimer interaction site [polypeptide binding]; other site 1211025008636 putative active site [active] 1211025008637 hypothetical protein; Provisional; Region: PRK05114 1211025008638 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1211025008639 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1211025008640 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1211025008641 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1211025008642 putative active site [active] 1211025008643 putative CoA binding site [chemical binding]; other site 1211025008644 nudix motif; other site 1211025008645 metal binding site [ion binding]; metal-binding site 1211025008646 L-serine deaminase; Provisional; Region: PRK15023 1211025008647 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1211025008648 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1211025008649 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1211025008650 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025008651 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1211025008652 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1211025008653 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1211025008654 Transporter associated domain; Region: CorC_HlyC; smart01091 1211025008655 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1211025008656 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1211025008657 active pocket/dimerization site; other site 1211025008658 active site 1211025008659 phosphorylation site [posttranslational modification] 1211025008660 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1211025008661 active site 1211025008662 phosphorylation site [posttranslational modification] 1211025008663 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1211025008664 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1211025008665 hypothetical protein; Provisional; Region: PRK02913 1211025008666 hypothetical protein; Provisional; Region: PRK11469 1211025008667 Domain of unknown function DUF; Region: DUF204; pfam02659 1211025008668 Domain of unknown function DUF; Region: DUF204; pfam02659 1211025008669 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1211025008670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025008671 S-adenosylmethionine binding site [chemical binding]; other site 1211025008672 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1211025008673 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1211025008674 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1211025008675 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1211025008676 DNA-binding site [nucleotide binding]; DNA binding site 1211025008677 RNA-binding motif; other site 1211025008678 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 1211025008679 YebO-like protein; Region: YebO; pfam13974 1211025008680 PhoPQ regulatory protein; Provisional; Region: PRK10299 1211025008681 YobH-like protein; Region: YobH; pfam13996 1211025008682 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1211025008683 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1211025008684 dimerization interface [polypeptide binding]; other site 1211025008685 putative Zn2+ binding site [ion binding]; other site 1211025008686 putative DNA binding site [nucleotide binding]; other site 1211025008687 Bacterial transcriptional regulator; Region: IclR; pfam01614 1211025008688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025008689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025008690 putative substrate translocation pore; other site 1211025008691 heat shock protein HtpX; Provisional; Region: PRK05457 1211025008692 carboxy-terminal protease; Provisional; Region: PRK11186 1211025008693 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1211025008694 protein binding site [polypeptide binding]; other site 1211025008695 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1211025008696 Catalytic dyad [active] 1211025008697 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1211025008698 ProP expression regulator; Provisional; Region: PRK04950 1211025008699 ProQ/FINO family; Region: ProQ; pfam04352 1211025008700 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1211025008701 GAF domain; Region: GAF_2; pfam13185 1211025008702 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1211025008703 Paraquat-inducible protein A; Region: PqiA; pfam04403 1211025008704 Paraquat-inducible protein A; Region: PqiA; pfam04403 1211025008705 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1211025008706 mce related protein; Region: MCE; pfam02470 1211025008707 mce related protein; Region: MCE; pfam02470 1211025008708 mce related protein; Region: MCE; pfam02470 1211025008709 mce related protein; Region: MCE; pfam02470 1211025008710 mce related protein; Region: MCE; pfam02470 1211025008711 mce related protein; Region: MCE; pfam02470 1211025008712 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1211025008713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025008714 S-adenosylmethionine binding site [chemical binding]; other site 1211025008715 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1211025008716 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1211025008717 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1211025008718 active site 1211025008719 metal binding site [ion binding]; metal-binding site 1211025008720 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1211025008721 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1211025008722 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1211025008723 CopC domain; Region: CopC; cl01012 1211025008724 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1211025008725 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1211025008726 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1211025008727 exodeoxyribonuclease X; Provisional; Region: PRK07983 1211025008728 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1211025008729 active site 1211025008730 catalytic site [active] 1211025008731 substrate binding site [chemical binding]; other site 1211025008732 protease 2; Provisional; Region: PRK10115 1211025008733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1211025008734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1211025008735 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1211025008736 putative metal binding site [ion binding]; other site 1211025008737 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1211025008738 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1211025008739 ATP-grasp domain; Region: ATP-grasp; pfam02222 1211025008740 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1211025008741 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1211025008742 active site 1211025008743 intersubunit interface [polypeptide binding]; other site 1211025008744 catalytic residue [active] 1211025008745 phosphogluconate dehydratase; Validated; Region: PRK09054 1211025008746 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1211025008747 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1211025008748 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1211025008749 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1211025008750 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1211025008751 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1211025008752 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1211025008753 putative active site [active] 1211025008754 pyruvate kinase; Provisional; Region: PRK05826 1211025008755 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1211025008756 domain interfaces; other site 1211025008757 active site 1211025008758 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1211025008759 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1211025008760 putative acyl-acceptor binding pocket; other site 1211025008761 putative peptidase; Provisional; Region: PRK11649 1211025008762 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1211025008763 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1211025008764 Peptidase family M23; Region: Peptidase_M23; pfam01551 1211025008765 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1211025008766 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1211025008767 metal binding site [ion binding]; metal-binding site 1211025008768 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1211025008769 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1211025008770 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1211025008771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025008772 ABC-ATPase subunit interface; other site 1211025008773 dimer interface [polypeptide binding]; other site 1211025008774 putative PBP binding regions; other site 1211025008775 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1211025008776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025008777 Walker A motif; other site 1211025008778 ATP binding site [chemical binding]; other site 1211025008779 Walker B motif; other site 1211025008780 arginine finger; other site 1211025008781 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1211025008782 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1211025008783 RuvA N terminal domain; Region: RuvA_N; pfam01330 1211025008784 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1211025008785 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1211025008786 active site 1211025008787 putative DNA-binding cleft [nucleotide binding]; other site 1211025008788 dimer interface [polypeptide binding]; other site 1211025008789 hypothetical protein; Validated; Region: PRK00110 1211025008790 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1211025008791 nudix motif; other site 1211025008792 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1211025008793 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1211025008794 dimer interface [polypeptide binding]; other site 1211025008795 anticodon binding site; other site 1211025008796 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1211025008797 homodimer interface [polypeptide binding]; other site 1211025008798 motif 1; other site 1211025008799 active site 1211025008800 motif 2; other site 1211025008801 GAD domain; Region: GAD; pfam02938 1211025008802 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1211025008803 active site 1211025008804 motif 3; other site 1211025008805 Isochorismatase family; Region: Isochorismatase; pfam00857 1211025008806 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1211025008807 catalytic triad [active] 1211025008808 conserved cis-peptide bond; other site 1211025008809 hypothetical protein; Provisional; Region: PRK10302 1211025008810 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1211025008811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025008812 S-adenosylmethionine binding site [chemical binding]; other site 1211025008813 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1211025008814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025008815 S-adenosylmethionine binding site [chemical binding]; other site 1211025008816 copper homeostasis protein CutC; Provisional; Region: PRK11572 1211025008817 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1211025008818 putative metal binding site [ion binding]; other site 1211025008819 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1211025008820 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1211025008821 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1211025008822 active site 1211025008823 HIGH motif; other site 1211025008824 KMSK motif region; other site 1211025008825 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1211025008826 tRNA binding surface [nucleotide binding]; other site 1211025008827 anticodon binding site; other site 1211025008828 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1211025008829 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1211025008830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025008831 Flagellar protein FlhE; Region: FlhE; pfam06366 1211025008832 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1211025008833 FHIPEP family; Region: FHIPEP; pfam00771 1211025008834 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1211025008835 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1211025008836 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1211025008837 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1211025008838 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025008839 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025008840 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025008841 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1211025008842 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025008843 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025008844 Fimbrial protein; Region: Fimbrial; cl01416 1211025008845 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1211025008846 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1211025008847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025008848 active site 1211025008849 phosphorylation site [posttranslational modification] 1211025008850 intermolecular recognition site; other site 1211025008851 dimerization interface [polypeptide binding]; other site 1211025008852 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1211025008853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025008854 active site 1211025008855 phosphorylation site [posttranslational modification] 1211025008856 intermolecular recognition site; other site 1211025008857 dimerization interface [polypeptide binding]; other site 1211025008858 CheB methylesterase; Region: CheB_methylest; pfam01339 1211025008859 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1211025008860 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1211025008861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025008862 S-adenosylmethionine binding site [chemical binding]; other site 1211025008863 methyl-accepting protein IV; Provisional; Region: PRK09793 1211025008864 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1211025008865 dimer interface [polypeptide binding]; other site 1211025008866 ligand binding site [chemical binding]; other site 1211025008867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025008868 dimerization interface [polypeptide binding]; other site 1211025008869 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025008870 dimer interface [polypeptide binding]; other site 1211025008871 putative CheW interface [polypeptide binding]; other site 1211025008872 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1211025008873 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1211025008874 dimer interface [polypeptide binding]; other site 1211025008875 ligand binding site [chemical binding]; other site 1211025008876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025008877 dimerization interface [polypeptide binding]; other site 1211025008878 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025008879 dimer interface [polypeptide binding]; other site 1211025008880 putative CheW interface [polypeptide binding]; other site 1211025008881 Spore Coat Protein U domain; Region: SCPU; pfam05229 1211025008882 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1211025008883 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025008884 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025008885 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1211025008886 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025008887 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025008888 Spore Coat Protein U domain; Region: SCPU; pfam05229 1211025008889 Spore Coat Protein U domain; Region: SCPU; pfam05229 1211025008890 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1211025008891 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1211025008892 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1211025008893 putative CheA interaction surface; other site 1211025008894 chemotaxis protein CheA; Provisional; Region: PRK10547 1211025008895 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1211025008896 putative binding surface; other site 1211025008897 active site 1211025008898 CheY binding; Region: CheY-binding; pfam09078 1211025008899 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1211025008900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025008901 ATP binding site [chemical binding]; other site 1211025008902 Mg2+ binding site [ion binding]; other site 1211025008903 G-X-G motif; other site 1211025008904 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1211025008905 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1211025008906 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1211025008907 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1211025008908 ligand binding site [chemical binding]; other site 1211025008909 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1211025008910 flagellar motor protein MotA; Validated; Region: PRK09110 1211025008911 transcriptional activator FlhC; Provisional; Region: PRK12722 1211025008912 transcriptional activator FlhD; Provisional; Region: PRK02909 1211025008913 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1211025008914 Ligand Binding Site [chemical binding]; other site 1211025008915 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1211025008916 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1211025008917 active site 1211025008918 homotetramer interface [polypeptide binding]; other site 1211025008919 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1211025008920 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1211025008921 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025008922 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025008923 TM-ABC transporter signature motif; other site 1211025008924 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1211025008925 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1211025008926 Walker A/P-loop; other site 1211025008927 ATP binding site [chemical binding]; other site 1211025008928 Q-loop/lid; other site 1211025008929 ABC transporter signature motif; other site 1211025008930 Walker B; other site 1211025008931 D-loop; other site 1211025008932 H-loop/switch region; other site 1211025008933 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1211025008934 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1211025008935 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1211025008936 ligand binding site [chemical binding]; other site 1211025008937 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1211025008938 Ferritin-like domain; Region: Ferritin; pfam00210 1211025008939 ferroxidase diiron center [ion binding]; other site 1211025008940 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1211025008941 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1211025008942 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1211025008943 YecR-like lipoprotein; Region: YecR; pfam13992 1211025008944 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1211025008945 Ferritin-like domain; Region: Ferritin; pfam00210 1211025008946 ferroxidase diiron center [ion binding]; other site 1211025008947 tyrosine transporter TyrP; Provisional; Region: PRK15132 1211025008948 aromatic amino acid transport protein; Region: araaP; TIGR00837 1211025008949 hypothetical protein; Provisional; Region: PRK10396 1211025008950 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 1211025008951 SEC-C motif; Region: SEC-C; pfam02810 1211025008952 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1211025008953 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1211025008954 dimerization interface [polypeptide binding]; other site 1211025008955 ligand binding site [chemical binding]; other site 1211025008956 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025008957 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1211025008958 TM-ABC transporter signature motif; other site 1211025008959 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1211025008960 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1211025008961 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1211025008962 TM-ABC transporter signature motif; other site 1211025008963 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1211025008964 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1211025008965 Walker A/P-loop; other site 1211025008966 ATP binding site [chemical binding]; other site 1211025008967 Q-loop/lid; other site 1211025008968 ABC transporter signature motif; other site 1211025008969 Walker B; other site 1211025008970 D-loop; other site 1211025008971 H-loop/switch region; other site 1211025008972 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1211025008973 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1211025008974 Walker A/P-loop; other site 1211025008975 ATP binding site [chemical binding]; other site 1211025008976 Q-loop/lid; other site 1211025008977 ABC transporter signature motif; other site 1211025008978 Walker B; other site 1211025008979 D-loop; other site 1211025008980 H-loop/switch region; other site 1211025008981 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 1211025008982 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1211025008983 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1211025008984 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1211025008985 GIY-YIG motif/motif A; other site 1211025008986 active site 1211025008987 catalytic site [active] 1211025008988 putative DNA binding site [nucleotide binding]; other site 1211025008989 metal binding site [ion binding]; metal-binding site 1211025008990 UvrB/uvrC motif; Region: UVR; pfam02151 1211025008991 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1211025008992 Helix-hairpin-helix motif; Region: HHH; pfam00633 1211025008993 response regulator; Provisional; Region: PRK09483 1211025008994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025008995 active site 1211025008996 phosphorylation site [posttranslational modification] 1211025008997 intermolecular recognition site; other site 1211025008998 dimerization interface [polypeptide binding]; other site 1211025008999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025009000 DNA binding residues [nucleotide binding] 1211025009001 dimerization interface [polypeptide binding]; other site 1211025009002 hypothetical protein; Provisional; Region: PRK10613 1211025009003 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1211025009004 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1211025009005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025009006 DNA binding residues [nucleotide binding] 1211025009007 dimerization interface [polypeptide binding]; other site 1211025009008 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1211025009009 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1211025009010 Walker A/P-loop; other site 1211025009011 ATP binding site [chemical binding]; other site 1211025009012 Q-loop/lid; other site 1211025009013 ABC transporter signature motif; other site 1211025009014 Walker B; other site 1211025009015 D-loop; other site 1211025009016 H-loop/switch region; other site 1211025009017 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1211025009018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025009019 dimer interface [polypeptide binding]; other site 1211025009020 conserved gate region; other site 1211025009021 putative PBP binding loops; other site 1211025009022 ABC-ATPase subunit interface; other site 1211025009023 D-cysteine desulfhydrase; Validated; Region: PRK03910 1211025009024 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1211025009025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025009026 catalytic residue [active] 1211025009027 cystine transporter subunit; Provisional; Region: PRK11260 1211025009028 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025009029 substrate binding pocket [chemical binding]; other site 1211025009030 membrane-bound complex binding site; other site 1211025009031 hinge residues; other site 1211025009032 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1211025009033 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1211025009034 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1211025009035 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1211025009036 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1211025009037 DNA binding residues [nucleotide binding] 1211025009038 flagellin; Validated; Region: PRK06819 1211025009039 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1211025009040 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1211025009041 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1211025009042 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1211025009043 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1211025009044 flagellar protein FliS; Validated; Region: fliS; PRK05685 1211025009045 Flagellar protein FliT; Region: FliT; cl05125 1211025009046 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1211025009047 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1211025009048 active site 1211025009049 Na/Ca binding site [ion binding]; other site 1211025009050 catalytic site [active] 1211025009051 lipoprotein; Provisional; Region: PRK10397 1211025009052 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1211025009053 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1211025009054 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1211025009055 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1211025009056 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1211025009057 FliG C-terminal domain; Region: FliG_C; pfam01706 1211025009058 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1211025009059 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1211025009060 Flagellar assembly protein FliH; Region: FliH; pfam02108 1211025009061 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1211025009062 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1211025009063 Walker A motif/ATP binding site; other site 1211025009064 Walker B motif; other site 1211025009065 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1211025009066 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1211025009067 flagellar hook-length control protein; Provisional; Region: PRK10118 1211025009068 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1211025009069 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1211025009070 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1211025009071 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1211025009072 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1211025009073 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1211025009074 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1211025009075 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1211025009076 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1211025009077 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1211025009078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025009079 DNA binding residues [nucleotide binding] 1211025009080 dimerization interface [polypeptide binding]; other site 1211025009081 hypothetical protein; Provisional; Region: PRK10708 1211025009082 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1211025009083 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1211025009084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025009085 active site 1211025009086 motif I; other site 1211025009087 motif II; other site 1211025009088 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1211025009089 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025009090 metal binding site [ion binding]; metal-binding site 1211025009091 active site 1211025009092 I-site; other site 1211025009093 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1211025009094 hypothetical protein; Provisional; Region: PRK10062 1211025009095 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1211025009096 EamA-like transporter family; Region: EamA; pfam00892 1211025009097 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1211025009098 additional DNA contacts [nucleotide binding]; other site 1211025009099 mismatch recognition site; other site 1211025009100 active site 1211025009101 zinc binding site [ion binding]; other site 1211025009102 DNA intercalation site [nucleotide binding]; other site 1211025009103 DNA cytosine methylase; Provisional; Region: PRK10458 1211025009104 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1211025009105 cofactor binding site; other site 1211025009106 DNA binding site [nucleotide binding] 1211025009107 substrate interaction site [chemical binding]; other site 1211025009108 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1211025009109 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1211025009110 Zn2+ binding site [ion binding]; other site 1211025009111 Mg2+ binding site [ion binding]; other site 1211025009112 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1211025009113 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1211025009114 trimer interface [polypeptide binding]; other site 1211025009115 eyelet of channel; other site 1211025009116 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1211025009117 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1211025009118 putative active site [active] 1211025009119 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1211025009120 PAS domain; Region: PAS; smart00091 1211025009121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025009122 ATP binding site [chemical binding]; other site 1211025009123 Mg2+ binding site [ion binding]; other site 1211025009124 G-X-G motif; other site 1211025009125 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1211025009126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025009127 active site 1211025009128 phosphorylation site [posttranslational modification] 1211025009129 intermolecular recognition site; other site 1211025009130 dimerization interface [polypeptide binding]; other site 1211025009131 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1211025009132 ApbE family; Region: ApbE; pfam02424 1211025009133 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1211025009134 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1211025009135 putative active site [active] 1211025009136 putative FMN binding site [chemical binding]; other site 1211025009137 putative substrate binding site [chemical binding]; other site 1211025009138 putative catalytic residue [active] 1211025009139 FMN-binding domain; Region: FMN_bind; cl01081 1211025009140 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1211025009141 L-aspartate oxidase; Provisional; Region: PRK06175 1211025009142 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1211025009143 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1211025009144 transmembrane helices; other site 1211025009145 fumarate hydratase; Provisional; Region: PRK15389 1211025009146 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1211025009147 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1211025009148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025009149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025009150 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1211025009151 dimerization interface [polypeptide binding]; other site 1211025009152 Beta-lactamase; Region: Beta-lactamase; pfam00144 1211025009153 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1211025009154 potential frameshift: common BLAST hit: gi|365971204|ref|YP_004952765.1| citrate-proton symporter 1211025009155 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1211025009156 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1211025009157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025009158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025009159 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1211025009160 putative dimerization interface [polypeptide binding]; other site 1211025009161 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1211025009162 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1211025009163 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1211025009164 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1211025009165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025009166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025009167 putative substrate translocation pore; other site 1211025009168 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1211025009169 IucA / IucC family; Region: IucA_IucC; pfam04183 1211025009170 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1211025009171 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1211025009172 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1211025009173 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1211025009174 IucA / IucC family; Region: IucA_IucC; pfam04183 1211025009175 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1211025009176 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1211025009177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1211025009178 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1211025009179 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025009180 N-terminal plug; other site 1211025009181 ligand-binding site [chemical binding]; other site 1211025009182 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1211025009183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025009184 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1211025009185 dimerization interface [polypeptide binding]; other site 1211025009186 substrate binding pocket [chemical binding]; other site 1211025009187 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1211025009188 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1211025009189 C-terminal domain interface [polypeptide binding]; other site 1211025009190 GSH binding site (G-site) [chemical binding]; other site 1211025009191 dimer interface [polypeptide binding]; other site 1211025009192 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1211025009193 N-terminal domain interface [polypeptide binding]; other site 1211025009194 dimer interface [polypeptide binding]; other site 1211025009195 substrate binding pocket (H-site) [chemical binding]; other site 1211025009196 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1211025009197 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1211025009198 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1211025009199 inhibitor-cofactor binding pocket; inhibition site 1211025009200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025009201 catalytic residue [active] 1211025009202 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1211025009203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1211025009204 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1211025009205 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1211025009206 dimer interface [polypeptide binding]; other site 1211025009207 active site 1211025009208 AMP-binding enzyme; Region: AMP-binding; pfam00501 1211025009209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1211025009210 active site 1211025009211 CoA binding site [chemical binding]; other site 1211025009212 AMP binding site [chemical binding]; other site 1211025009213 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1211025009214 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1211025009215 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1211025009216 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1211025009217 homotrimer interaction site [polypeptide binding]; other site 1211025009218 putative active site [active] 1211025009219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025009220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025009221 putative substrate translocation pore; other site 1211025009222 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1211025009223 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 1211025009224 putative substrate binding site [chemical binding]; other site 1211025009225 dimerization interface [polypeptide binding]; other site 1211025009226 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1211025009227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025009228 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1211025009229 putative dimerization interface [polypeptide binding]; other site 1211025009230 L,D-transpeptidase; Provisional; Region: PRK10190 1211025009231 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1211025009232 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1211025009233 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1211025009234 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1211025009235 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1211025009236 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1211025009237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025009238 active site 1211025009239 motif I; other site 1211025009240 motif II; other site 1211025009241 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1211025009242 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1211025009243 Ligand Binding Site [chemical binding]; other site 1211025009244 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1211025009245 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025009246 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1211025009247 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1211025009248 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1211025009249 shikimate transporter; Provisional; Region: PRK09952 1211025009250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025009251 putative substrate translocation pore; other site 1211025009252 AMP nucleosidase; Provisional; Region: PRK08292 1211025009253 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1211025009254 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1211025009255 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1211025009256 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1211025009257 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1211025009258 active site 1211025009259 MATE family multidrug exporter; Provisional; Region: PRK10189 1211025009260 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1211025009261 hypothetical protein; Provisional; Region: PRK05423 1211025009262 Predicted membrane protein [Function unknown]; Region: COG1289 1211025009263 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1211025009264 DNA gyrase inhibitor; Provisional; Region: PRK10016 1211025009265 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1211025009266 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1211025009267 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1211025009268 exonuclease I; Provisional; Region: sbcB; PRK11779 1211025009269 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1211025009270 active site 1211025009271 catalytic site [active] 1211025009272 substrate binding site [chemical binding]; other site 1211025009273 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1211025009274 amino acid transporter; Region: 2A0306; TIGR00909 1211025009275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025009276 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1211025009277 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025009278 dimerization interface [polypeptide binding]; other site 1211025009279 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1211025009280 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1211025009281 putative NAD(P) binding site [chemical binding]; other site 1211025009282 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1211025009283 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1211025009284 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1211025009285 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1211025009286 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1211025009287 NAD binding site [chemical binding]; other site 1211025009288 dimerization interface [polypeptide binding]; other site 1211025009289 product binding site; other site 1211025009290 substrate binding site [chemical binding]; other site 1211025009291 zinc binding site [ion binding]; other site 1211025009292 catalytic residues [active] 1211025009293 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1211025009294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025009295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025009296 homodimer interface [polypeptide binding]; other site 1211025009297 catalytic residue [active] 1211025009298 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1211025009299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025009300 active site 1211025009301 motif I; other site 1211025009302 motif II; other site 1211025009303 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1211025009304 putative active site pocket [active] 1211025009305 4-fold oligomerization interface [polypeptide binding]; other site 1211025009306 metal binding residues [ion binding]; metal-binding site 1211025009307 3-fold/trimer interface [polypeptide binding]; other site 1211025009308 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1211025009309 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1211025009310 putative active site [active] 1211025009311 oxyanion strand; other site 1211025009312 catalytic triad [active] 1211025009313 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1211025009314 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1211025009315 catalytic residues [active] 1211025009316 potential frameshift: common BLAST hit: gi|296103682|ref|YP_003613828.1| imidazole glycerol phosphate synthase subunit HisF 1211025009317 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1211025009318 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1211025009319 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1211025009320 metal binding site [ion binding]; metal-binding site 1211025009321 chain length determinant protein WzzB; Provisional; Region: PRK15471 1211025009322 Chain length determinant protein; Region: Wzz; pfam02706 1211025009323 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1211025009324 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1211025009325 putative NAD(P) binding site [chemical binding]; other site 1211025009326 active site 1211025009327 putative substrate binding site [chemical binding]; other site 1211025009328 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1211025009329 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1211025009330 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1211025009331 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1211025009332 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1211025009333 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1211025009334 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1211025009335 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1211025009336 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1211025009337 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1211025009338 NADP binding site [chemical binding]; other site 1211025009339 active site 1211025009340 putative substrate binding site [chemical binding]; other site 1211025009341 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1211025009342 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1211025009343 substrate binding site; other site 1211025009344 tetramer interface; other site 1211025009345 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1211025009346 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1211025009347 NAD binding site [chemical binding]; other site 1211025009348 substrate binding site [chemical binding]; other site 1211025009349 homodimer interface [polypeptide binding]; other site 1211025009350 active site 1211025009351 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1211025009352 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1211025009353 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1211025009354 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1211025009355 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1211025009356 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1211025009357 putative ADP-binding pocket [chemical binding]; other site 1211025009358 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1211025009359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1211025009360 putative homodimer interface [polypeptide binding]; other site 1211025009361 integral membrane protein MviN; Region: mviN; TIGR01695 1211025009362 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1211025009363 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1211025009364 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1211025009365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1211025009366 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 1211025009367 putative ADP-binding pocket [chemical binding]; other site 1211025009368 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1211025009369 O-Antigen ligase; Region: Wzy_C; pfam04932 1211025009370 phosphomannomutase CpsG; Provisional; Region: PRK15414 1211025009371 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1211025009372 active site 1211025009373 substrate binding site [chemical binding]; other site 1211025009374 metal binding site [ion binding]; metal-binding site 1211025009375 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1211025009376 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1211025009377 Substrate binding site; other site 1211025009378 Cupin domain; Region: Cupin_2; cl17218 1211025009379 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1211025009380 active site 1211025009381 tetramer interface; other site 1211025009382 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 1211025009383 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1211025009384 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1211025009385 putative ADP-binding pocket [chemical binding]; other site 1211025009386 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 1211025009387 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1211025009388 colanic acid exporter; Provisional; Region: PRK10459 1211025009389 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1211025009390 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1211025009391 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1211025009392 phosphomannomutase CpsG; Provisional; Region: PRK15414 1211025009393 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1211025009394 active site 1211025009395 substrate binding site [chemical binding]; other site 1211025009396 metal binding site [ion binding]; metal-binding site 1211025009397 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1211025009398 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1211025009399 Substrate binding site; other site 1211025009400 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1211025009401 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1211025009402 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1211025009403 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1211025009404 active site 1211025009405 GDP-Mannose binding site [chemical binding]; other site 1211025009406 dimer interface [polypeptide binding]; other site 1211025009407 modified nudix motif 1211025009408 metal binding site [ion binding]; metal-binding site 1211025009409 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1211025009410 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1211025009411 NADP binding site [chemical binding]; other site 1211025009412 active site 1211025009413 putative substrate binding site [chemical binding]; other site 1211025009414 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1211025009415 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1211025009416 NADP-binding site; other site 1211025009417 homotetramer interface [polypeptide binding]; other site 1211025009418 substrate binding site [chemical binding]; other site 1211025009419 homodimer interface [polypeptide binding]; other site 1211025009420 active site 1211025009421 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1211025009422 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1211025009423 putative trimer interface [polypeptide binding]; other site 1211025009424 putative active site [active] 1211025009425 putative substrate binding site [chemical binding]; other site 1211025009426 putative CoA binding site [chemical binding]; other site 1211025009427 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1211025009428 putative glycosyl transferase; Provisional; Region: PRK10063 1211025009429 active site 1211025009430 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1211025009431 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1211025009432 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1211025009433 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1211025009434 putative acyl transferase; Provisional; Region: PRK10191 1211025009435 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1211025009436 trimer interface [polypeptide binding]; other site 1211025009437 active site 1211025009438 substrate binding site [chemical binding]; other site 1211025009439 CoA binding site [chemical binding]; other site 1211025009440 putative glycosyl transferase; Provisional; Region: PRK10018 1211025009441 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1211025009442 active site 1211025009443 tyrosine kinase; Provisional; Region: PRK11519 1211025009444 Chain length determinant protein; Region: Wzz; pfam02706 1211025009445 Chain length determinant protein; Region: Wzz; cl15801 1211025009446 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1211025009447 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1211025009448 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1211025009449 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1211025009450 active site 1211025009451 polysaccharide export protein Wza; Provisional; Region: PRK15078 1211025009452 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1211025009453 SLBB domain; Region: SLBB; pfam10531 1211025009454 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1211025009455 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1211025009456 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1211025009457 Transporter associated domain; Region: CorC_HlyC; smart01091 1211025009458 putative assembly protein; Provisional; Region: PRK10833 1211025009459 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1211025009460 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1211025009461 trimer interface [polypeptide binding]; other site 1211025009462 active site 1211025009463 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1211025009464 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1211025009465 ATP-binding site [chemical binding]; other site 1211025009466 Sugar specificity; other site 1211025009467 Pyrimidine base specificity; other site 1211025009468 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1211025009469 putative diguanylate cyclase; Provisional; Region: PRK09776 1211025009470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025009471 putative active site [active] 1211025009472 heme pocket [chemical binding]; other site 1211025009473 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025009474 putative active site [active] 1211025009475 heme pocket [chemical binding]; other site 1211025009476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025009477 putative active site [active] 1211025009478 heme pocket [chemical binding]; other site 1211025009479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025009480 metal binding site [ion binding]; metal-binding site 1211025009481 active site 1211025009482 I-site; other site 1211025009483 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1211025009484 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1211025009485 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1211025009486 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1211025009487 minor groove reading motif; other site 1211025009488 helix-hairpin-helix signature motif; other site 1211025009489 substrate binding pocket [chemical binding]; other site 1211025009490 active site 1211025009491 putative chaperone; Provisional; Region: PRK11678 1211025009492 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1211025009493 nucleotide binding site [chemical binding]; other site 1211025009494 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1211025009495 SBD interface [polypeptide binding]; other site 1211025009496 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1211025009497 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025009498 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025009499 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1211025009500 Protein export membrane protein; Region: SecD_SecF; cl14618 1211025009501 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1211025009502 putative transporter; Provisional; Region: PRK10504 1211025009503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025009504 putative substrate translocation pore; other site 1211025009505 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1211025009506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025009507 dimerization interface [polypeptide binding]; other site 1211025009508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025009509 dimer interface [polypeptide binding]; other site 1211025009510 phosphorylation site [posttranslational modification] 1211025009511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025009512 ATP binding site [chemical binding]; other site 1211025009513 Mg2+ binding site [ion binding]; other site 1211025009514 G-X-G motif; other site 1211025009515 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1211025009516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025009517 active site 1211025009518 phosphorylation site [posttranslational modification] 1211025009519 intermolecular recognition site; other site 1211025009520 dimerization interface [polypeptide binding]; other site 1211025009521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025009522 DNA binding site [nucleotide binding] 1211025009523 putative protease; Provisional; Region: PRK15452 1211025009524 Peptidase family U32; Region: Peptidase_U32; pfam01136 1211025009525 lipid kinase; Reviewed; Region: PRK13054 1211025009526 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1211025009527 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1211025009528 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1211025009529 putative active site; other site 1211025009530 catalytic residue [active] 1211025009531 nucleoside transporter; Region: 2A0110; TIGR00889 1211025009532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025009533 putative substrate translocation pore; other site 1211025009534 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1211025009535 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1211025009536 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1211025009537 substrate binding site [chemical binding]; other site 1211025009538 ATP binding site [chemical binding]; other site 1211025009539 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1211025009540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025009541 DNA-binding site [nucleotide binding]; DNA binding site 1211025009542 UTRA domain; Region: UTRA; pfam07702 1211025009543 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1211025009544 dimer interface [polypeptide binding]; other site 1211025009545 substrate binding site [chemical binding]; other site 1211025009546 ATP binding site [chemical binding]; other site 1211025009547 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1211025009548 substrate binding site [chemical binding]; other site 1211025009549 multimerization interface [polypeptide binding]; other site 1211025009550 ATP binding site [chemical binding]; other site 1211025009551 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1211025009552 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1211025009553 substrate binding [chemical binding]; other site 1211025009554 active site 1211025009555 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1211025009556 galactoside permease; Reviewed; Region: lacY; PRK09528 1211025009557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025009558 putative substrate translocation pore; other site 1211025009559 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025009560 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025009561 DNA binding site [nucleotide binding] 1211025009562 domain linker motif; other site 1211025009563 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1211025009564 putative dimerization interface [polypeptide binding]; other site 1211025009565 putative ligand binding site [chemical binding]; other site 1211025009566 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 1211025009567 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1211025009568 inhibitor-cofactor binding pocket; inhibition site 1211025009569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025009570 catalytic residue [active] 1211025009571 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1211025009572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025009573 catalytic residue [active] 1211025009574 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1211025009575 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1211025009576 catalytic residues [active] 1211025009577 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 1211025009578 Chain length determinant protein; Region: Wzz; pfam02706 1211025009579 Chain length determinant protein; Region: Wzz; cl15801 1211025009580 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1211025009581 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1211025009582 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1211025009583 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1211025009584 polysaccharide export protein Wza; Provisional; Region: PRK15078 1211025009585 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1211025009586 SLBB domain; Region: SLBB; pfam10531 1211025009587 SLBB domain; Region: SLBB; pfam10531 1211025009588 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1211025009589 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1211025009590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025009591 Coenzyme A binding pocket [chemical binding]; other site 1211025009592 antiporter inner membrane protein; Provisional; Region: PRK11670 1211025009593 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1211025009594 Walker A motif; other site 1211025009595 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1211025009596 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1211025009597 active site 1211025009598 HIGH motif; other site 1211025009599 KMSKS motif; other site 1211025009600 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1211025009601 tRNA binding surface [nucleotide binding]; other site 1211025009602 anticodon binding site; other site 1211025009603 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1211025009604 dimer interface [polypeptide binding]; other site 1211025009605 putative tRNA-binding site [nucleotide binding]; other site 1211025009606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1211025009607 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1211025009608 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1211025009609 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1211025009610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025009611 active site 1211025009612 phosphorylation site [posttranslational modification] 1211025009613 intermolecular recognition site; other site 1211025009614 dimerization interface [polypeptide binding]; other site 1211025009615 LytTr DNA-binding domain; Region: LytTR; pfam04397 1211025009616 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1211025009617 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1211025009618 GAF domain; Region: GAF; pfam01590 1211025009619 Histidine kinase; Region: His_kinase; pfam06580 1211025009620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025009621 ATP binding site [chemical binding]; other site 1211025009622 Mg2+ binding site [ion binding]; other site 1211025009623 G-X-G motif; other site 1211025009624 transcriptional regulator MirA; Provisional; Region: PRK15043 1211025009625 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1211025009626 DNA binding residues [nucleotide binding] 1211025009627 hypothetical protein; Provisional; Region: PRK13681 1211025009628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025009629 dimer interface [polypeptide binding]; other site 1211025009630 conserved gate region; other site 1211025009631 putative PBP binding loops; other site 1211025009632 ABC-ATPase subunit interface; other site 1211025009633 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1211025009634 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1211025009635 Walker A/P-loop; other site 1211025009636 ATP binding site [chemical binding]; other site 1211025009637 Q-loop/lid; other site 1211025009638 ABC transporter signature motif; other site 1211025009639 Walker B; other site 1211025009640 D-loop; other site 1211025009641 H-loop/switch region; other site 1211025009642 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1211025009643 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1211025009644 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1211025009645 potential frameshift: common BLAST hit: gi|296103779|ref|YP_003613925.1| putative periplasmic beta-glucosidase 1211025009646 D-lactate dehydrogenase; Provisional; Region: PRK11183 1211025009647 FAD binding domain; Region: FAD_binding_4; pfam01565 1211025009648 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1211025009649 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1211025009650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025009651 Coenzyme A binding pocket [chemical binding]; other site 1211025009652 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1211025009653 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1211025009654 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1211025009655 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1211025009656 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1211025009657 oxidoreductase; Provisional; Region: PRK12743 1211025009658 classical (c) SDRs; Region: SDR_c; cd05233 1211025009659 NAD(P) binding site [chemical binding]; other site 1211025009660 active site 1211025009661 Outer membrane efflux protein; Region: OEP; pfam02321 1211025009662 Outer membrane efflux protein; Region: OEP; pfam02321 1211025009663 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1211025009664 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1211025009665 FMN binding site [chemical binding]; other site 1211025009666 active site 1211025009667 catalytic residues [active] 1211025009668 substrate binding site [chemical binding]; other site 1211025009669 hypothetical protein; Provisional; Region: PRK01821 1211025009670 hypothetical protein; Provisional; Region: PRK10711 1211025009671 cytidine deaminase; Provisional; Region: PRK09027 1211025009672 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1211025009673 active site 1211025009674 catalytic motif [active] 1211025009675 Zn binding site [ion binding]; other site 1211025009676 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1211025009677 active site 1211025009678 catalytic motif [active] 1211025009679 Zn binding site [ion binding]; other site 1211025009680 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1211025009681 putative active site [active] 1211025009682 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1211025009683 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1211025009684 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025009685 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025009686 TM-ABC transporter signature motif; other site 1211025009687 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1211025009688 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1211025009689 Walker A/P-loop; other site 1211025009690 ATP binding site [chemical binding]; other site 1211025009691 Q-loop/lid; other site 1211025009692 ABC transporter signature motif; other site 1211025009693 Walker B; other site 1211025009694 D-loop; other site 1211025009695 H-loop/switch region; other site 1211025009696 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1211025009697 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1211025009698 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1211025009699 ligand binding site [chemical binding]; other site 1211025009700 calcium binding site [ion binding]; other site 1211025009701 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1211025009702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025009703 DNA binding site [nucleotide binding] 1211025009704 domain linker motif; other site 1211025009705 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1211025009706 dimerization interface (closed form) [polypeptide binding]; other site 1211025009707 ligand binding site [chemical binding]; other site 1211025009708 Predicted membrane protein [Function unknown]; Region: COG2311 1211025009709 hypothetical protein; Provisional; Region: PRK10835 1211025009710 GTP cyclohydrolase I; Provisional; Region: PLN03044 1211025009711 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1211025009712 active site 1211025009713 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1211025009714 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1211025009715 S-formylglutathione hydrolase; Region: PLN02442 1211025009716 putative outer membrane receptor; Provisional; Region: PRK13513 1211025009717 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025009718 N-terminal plug; other site 1211025009719 ligand-binding site [chemical binding]; other site 1211025009720 lysine transporter; Provisional; Region: PRK10836 1211025009721 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1211025009722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025009723 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1211025009724 putative dimerization interface [polypeptide binding]; other site 1211025009725 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1211025009726 endonuclease IV; Provisional; Region: PRK01060 1211025009727 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1211025009728 DNA interaction; other site 1211025009729 Metal-binding active site; metal-binding site 1211025009730 AP (apurinic/apyrimidinic) site pocket; other site 1211025009731 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1211025009732 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1211025009733 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1211025009734 active site 1211025009735 P-loop; other site 1211025009736 phosphorylation site [posttranslational modification] 1211025009737 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1211025009738 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1211025009739 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1211025009740 putative substrate binding site [chemical binding]; other site 1211025009741 putative ATP binding site [chemical binding]; other site 1211025009742 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1211025009743 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1211025009744 active site 1211025009745 phosphorylation site [posttranslational modification] 1211025009746 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1211025009747 dimerization domain swap beta strand [polypeptide binding]; other site 1211025009748 regulatory protein interface [polypeptide binding]; other site 1211025009749 active site 1211025009750 regulatory phosphorylation site [posttranslational modification]; other site 1211025009751 sugar efflux transporter B; Provisional; Region: PRK15011 1211025009752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025009753 putative substrate translocation pore; other site 1211025009754 Flagellin N-methylase; Region: FliB; cl00497 1211025009755 elongation factor P; Provisional; Region: PRK04542 1211025009756 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1211025009757 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1211025009758 RNA binding site [nucleotide binding]; other site 1211025009759 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1211025009760 RNA binding site [nucleotide binding]; other site 1211025009761 mannonate dehydratase; Provisional; Region: PRK03906 1211025009762 mannonate dehydratase; Region: uxuA; TIGR00695 1211025009763 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1211025009764 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1211025009765 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1211025009766 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1211025009767 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1211025009768 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1211025009769 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1211025009770 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1211025009771 active site 1211025009772 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1211025009773 NlpC/P60 family; Region: NLPC_P60; pfam00877 1211025009774 phage resistance protein; Provisional; Region: PRK10551 1211025009775 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1211025009776 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025009777 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1211025009778 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1211025009779 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1211025009780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025009781 dimer interface [polypeptide binding]; other site 1211025009782 conserved gate region; other site 1211025009783 putative PBP binding loops; other site 1211025009784 ABC-ATPase subunit interface; other site 1211025009785 microcin C ABC transporter permease; Provisional; Region: PRK15021 1211025009786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025009787 dimer interface [polypeptide binding]; other site 1211025009788 conserved gate region; other site 1211025009789 ABC-ATPase subunit interface; other site 1211025009790 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1211025009791 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025009792 Walker A/P-loop; other site 1211025009793 ATP binding site [chemical binding]; other site 1211025009794 Q-loop/lid; other site 1211025009795 ABC transporter signature motif; other site 1211025009796 Walker B; other site 1211025009797 D-loop; other site 1211025009798 H-loop/switch region; other site 1211025009799 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1211025009800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1211025009801 Walker A/P-loop; other site 1211025009802 ATP binding site [chemical binding]; other site 1211025009803 Q-loop/lid; other site 1211025009804 ABC transporter signature motif; other site 1211025009805 Walker B; other site 1211025009806 D-loop; other site 1211025009807 H-loop/switch region; other site 1211025009808 hypothetical protein; Provisional; Region: PRK11835 1211025009809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025009810 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1211025009811 putative substrate translocation pore; other site 1211025009812 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1211025009813 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1211025009814 RNA binding surface [nucleotide binding]; other site 1211025009815 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1211025009816 active site 1211025009817 uracil binding [chemical binding]; other site 1211025009818 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1211025009819 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025009820 ATP binding site [chemical binding]; other site 1211025009821 putative Mg++ binding site [ion binding]; other site 1211025009822 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025009823 nucleotide binding region [chemical binding]; other site 1211025009824 ATP-binding site [chemical binding]; other site 1211025009825 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1211025009826 5S rRNA interface [nucleotide binding]; other site 1211025009827 CTC domain interface [polypeptide binding]; other site 1211025009828 L16 interface [polypeptide binding]; other site 1211025009829 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1211025009830 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1211025009831 hypothetical protein; Provisional; Region: PRK13689 1211025009832 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1211025009833 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1211025009834 Sulfatase; Region: Sulfatase; cl17466 1211025009835 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1211025009836 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1211025009837 secondary substrate binding site; other site 1211025009838 primary substrate binding site; other site 1211025009839 inhibition loop; other site 1211025009840 dimerization interface [polypeptide binding]; other site 1211025009841 malate:quinone oxidoreductase; Validated; Region: PRK05257 1211025009842 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1211025009843 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1211025009844 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1211025009845 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1211025009846 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1211025009847 MgtE intracellular N domain; Region: MgtE_N; smart00924 1211025009848 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1211025009849 Divalent cation transporter; Region: MgtE; cl00786 1211025009850 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1211025009851 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1211025009852 Walker A/P-loop; other site 1211025009853 ATP binding site [chemical binding]; other site 1211025009854 Q-loop/lid; other site 1211025009855 ABC transporter signature motif; other site 1211025009856 Walker B; other site 1211025009857 D-loop; other site 1211025009858 H-loop/switch region; other site 1211025009859 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1211025009860 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1211025009861 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1211025009862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025009863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025009864 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1211025009865 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1211025009866 DNA binding site [nucleotide binding] 1211025009867 active site 1211025009868 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1211025009869 ApbE family; Region: ApbE; pfam02424 1211025009870 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1211025009871 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1211025009872 trimer interface [polypeptide binding]; other site 1211025009873 eyelet of channel; other site 1211025009874 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1211025009875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025009876 ATP binding site [chemical binding]; other site 1211025009877 Mg2+ binding site [ion binding]; other site 1211025009878 G-X-G motif; other site 1211025009879 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1211025009880 putative binding surface; other site 1211025009881 active site 1211025009882 transcriptional regulator RcsB; Provisional; Region: PRK10840 1211025009883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025009884 active site 1211025009885 phosphorylation site [posttranslational modification] 1211025009886 intermolecular recognition site; other site 1211025009887 dimerization interface [polypeptide binding]; other site 1211025009888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025009889 DNA binding residues [nucleotide binding] 1211025009890 dimerization interface [polypeptide binding]; other site 1211025009891 potential frameshift: common BLAST hit: gi|296103859|ref|YP_003614005.1| two-component system, NarL family, capsular synthesis sensor 1211025009892 DNA gyrase subunit A; Validated; Region: PRK05560 1211025009893 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1211025009894 CAP-like domain; other site 1211025009895 active site 1211025009896 primary dimer interface [polypeptide binding]; other site 1211025009897 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1211025009898 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1211025009899 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1211025009900 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1211025009901 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1211025009902 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1211025009903 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1211025009904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025009905 S-adenosylmethionine binding site [chemical binding]; other site 1211025009906 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1211025009907 ATP cone domain; Region: ATP-cone; pfam03477 1211025009908 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1211025009909 active site 1211025009910 dimer interface [polypeptide binding]; other site 1211025009911 catalytic residues [active] 1211025009912 effector binding site; other site 1211025009913 R2 peptide binding site; other site 1211025009914 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1211025009915 dimer interface [polypeptide binding]; other site 1211025009916 putative radical transfer pathway; other site 1211025009917 diiron center [ion binding]; other site 1211025009918 tyrosyl radical; other site 1211025009919 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1211025009920 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1211025009921 catalytic loop [active] 1211025009922 iron binding site [ion binding]; other site 1211025009923 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1211025009924 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1211025009925 active site 1211025009926 catalytic site [active] 1211025009927 metal binding site [ion binding]; metal-binding site 1211025009928 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1211025009929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025009930 putative substrate translocation pore; other site 1211025009931 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1211025009932 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1211025009933 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1211025009934 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1211025009935 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1211025009936 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1211025009937 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1211025009938 Cysteine-rich domain; Region: CCG; pfam02754 1211025009939 Cysteine-rich domain; Region: CCG; pfam02754 1211025009940 hypothetical protein; Provisional; Region: PRK03673 1211025009941 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1211025009942 putative MPT binding site; other site 1211025009943 Competence-damaged protein; Region: CinA; cl00666 1211025009944 YfaZ precursor; Region: YfaZ; pfam07437 1211025009945 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1211025009946 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1211025009947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1211025009948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025009949 dimer interface [polypeptide binding]; other site 1211025009950 phosphorylation site [posttranslational modification] 1211025009951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025009952 ATP binding site [chemical binding]; other site 1211025009953 Mg2+ binding site [ion binding]; other site 1211025009954 G-X-G motif; other site 1211025009955 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1211025009956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025009957 active site 1211025009958 phosphorylation site [posttranslational modification] 1211025009959 intermolecular recognition site; other site 1211025009960 dimerization interface [polypeptide binding]; other site 1211025009961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025009962 DNA binding site [nucleotide binding] 1211025009963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1211025009964 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1211025009965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1211025009966 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1211025009967 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1211025009968 acyl-activating enzyme (AAE) consensus motif; other site 1211025009969 putative AMP binding site [chemical binding]; other site 1211025009970 putative active site [active] 1211025009971 putative CoA binding site [chemical binding]; other site 1211025009972 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1211025009973 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1211025009974 active site 1211025009975 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1211025009976 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1211025009977 substrate binding site [chemical binding]; other site 1211025009978 oxyanion hole (OAH) forming residues; other site 1211025009979 trimer interface [polypeptide binding]; other site 1211025009980 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1211025009981 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1211025009982 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1211025009983 dimer interface [polypeptide binding]; other site 1211025009984 tetramer interface [polypeptide binding]; other site 1211025009985 PYR/PP interface [polypeptide binding]; other site 1211025009986 TPP binding site [chemical binding]; other site 1211025009987 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1211025009988 TPP-binding site; other site 1211025009989 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1211025009990 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1211025009991 hypothetical protein; Provisional; Region: PRK10404 1211025009992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025009993 Coenzyme A binding pocket [chemical binding]; other site 1211025009994 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1211025009995 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1211025009996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025009997 Response regulator receiver domain; Region: Response_reg; pfam00072 1211025009998 active site 1211025009999 phosphorylation site [posttranslational modification] 1211025010000 intermolecular recognition site; other site 1211025010001 dimerization interface [polypeptide binding]; other site 1211025010002 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1211025010003 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1211025010004 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1211025010005 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1211025010006 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1211025010007 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1211025010008 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1211025010009 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1211025010010 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1211025010011 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1211025010012 4Fe-4S binding domain; Region: Fer4; pfam00037 1211025010013 4Fe-4S binding domain; Region: Fer4; pfam00037 1211025010014 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1211025010015 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1211025010016 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1211025010017 catalytic loop [active] 1211025010018 iron binding site [ion binding]; other site 1211025010019 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1211025010020 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1211025010021 [4Fe-4S] binding site [ion binding]; other site 1211025010022 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1211025010023 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1211025010024 SLBB domain; Region: SLBB; pfam10531 1211025010025 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1211025010026 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1211025010027 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1211025010028 putative dimer interface [polypeptide binding]; other site 1211025010029 [2Fe-2S] cluster binding site [ion binding]; other site 1211025010030 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1211025010031 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1211025010032 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1211025010033 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1211025010034 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1211025010035 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1211025010036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025010037 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1211025010038 putative dimerization interface [polypeptide binding]; other site 1211025010039 aminotransferase AlaT; Validated; Region: PRK09265 1211025010040 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025010041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025010042 homodimer interface [polypeptide binding]; other site 1211025010043 catalytic residue [active] 1211025010044 5'-nucleotidase; Provisional; Region: PRK03826 1211025010045 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1211025010046 transmembrane helices; other site 1211025010047 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1211025010048 TrkA-C domain; Region: TrkA_C; pfam02080 1211025010049 TrkA-C domain; Region: TrkA_C; pfam02080 1211025010050 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1211025010051 putative phosphatase; Provisional; Region: PRK11587 1211025010052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025010053 motif II; other site 1211025010054 hypothetical protein; Validated; Region: PRK05445 1211025010055 hypothetical protein; Provisional; Region: PRK01816 1211025010056 propionate/acetate kinase; Provisional; Region: PRK12379 1211025010057 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1211025010058 phosphate acetyltransferase; Reviewed; Region: PRK05632 1211025010059 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1211025010060 DRTGG domain; Region: DRTGG; pfam07085 1211025010061 phosphate acetyltransferase; Region: pta; TIGR00651 1211025010062 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1211025010063 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1211025010064 PYR/PP interface [polypeptide binding]; other site 1211025010065 dimer interface [polypeptide binding]; other site 1211025010066 TPP binding site [chemical binding]; other site 1211025010067 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1211025010068 transketolase; Reviewed; Region: PRK05899 1211025010069 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1211025010070 TPP-binding site [chemical binding]; other site 1211025010071 dimer interface [polypeptide binding]; other site 1211025010072 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 1211025010073 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1211025010074 active site 1211025010075 P-loop; other site 1211025010076 phosphorylation site [posttranslational modification] 1211025010077 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1211025010078 active site 1211025010079 phosphorylation site [posttranslational modification] 1211025010080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025010081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025010082 DNA binding site [nucleotide binding] 1211025010083 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1211025010084 putative dimerization interface [polypeptide binding]; other site 1211025010085 putative ligand binding site [chemical binding]; other site 1211025010086 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1211025010087 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1211025010088 nudix motif; other site 1211025010089 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1211025010090 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1211025010091 active site 1211025010092 metal binding site [ion binding]; metal-binding site 1211025010093 homotetramer interface [polypeptide binding]; other site 1211025010094 glutathione S-transferase; Provisional; Region: PRK15113 1211025010095 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1211025010096 C-terminal domain interface [polypeptide binding]; other site 1211025010097 GSH binding site (G-site) [chemical binding]; other site 1211025010098 dimer interface [polypeptide binding]; other site 1211025010099 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1211025010100 N-terminal domain interface [polypeptide binding]; other site 1211025010101 putative dimer interface [polypeptide binding]; other site 1211025010102 putative substrate binding pocket (H-site) [chemical binding]; other site 1211025010103 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1211025010104 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1211025010105 C-terminal domain interface [polypeptide binding]; other site 1211025010106 GSH binding site (G-site) [chemical binding]; other site 1211025010107 dimer interface [polypeptide binding]; other site 1211025010108 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1211025010109 N-terminal domain interface [polypeptide binding]; other site 1211025010110 putative dimer interface [polypeptide binding]; other site 1211025010111 active site 1211025010112 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1211025010113 homooctamer interface [polypeptide binding]; other site 1211025010114 active site 1211025010115 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1211025010116 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1211025010117 putative NAD(P) binding site [chemical binding]; other site 1211025010118 putative active site [active] 1211025010119 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1211025010120 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1211025010121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025010122 non-specific DNA binding site [nucleotide binding]; other site 1211025010123 salt bridge; other site 1211025010124 sequence-specific DNA binding site [nucleotide binding]; other site 1211025010125 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1211025010126 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1211025010127 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1211025010128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025010129 Coenzyme A binding pocket [chemical binding]; other site 1211025010130 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1211025010131 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1211025010132 Walker A/P-loop; other site 1211025010133 ATP binding site [chemical binding]; other site 1211025010134 Q-loop/lid; other site 1211025010135 ABC transporter signature motif; other site 1211025010136 Walker B; other site 1211025010137 D-loop; other site 1211025010138 H-loop/switch region; other site 1211025010139 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1211025010140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025010141 dimer interface [polypeptide binding]; other site 1211025010142 conserved gate region; other site 1211025010143 putative PBP binding loops; other site 1211025010144 ABC-ATPase subunit interface; other site 1211025010145 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1211025010146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025010147 dimer interface [polypeptide binding]; other site 1211025010148 conserved gate region; other site 1211025010149 putative PBP binding loops; other site 1211025010150 ABC-ATPase subunit interface; other site 1211025010151 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1211025010152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025010153 substrate binding pocket [chemical binding]; other site 1211025010154 membrane-bound complex binding site; other site 1211025010155 hinge residues; other site 1211025010156 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1211025010157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025010158 substrate binding pocket [chemical binding]; other site 1211025010159 membrane-bound complex binding site; other site 1211025010160 hinge residues; other site 1211025010161 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1211025010162 Flavoprotein; Region: Flavoprotein; pfam02441 1211025010163 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1211025010164 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1211025010165 active site 1211025010166 tetramer interface [polypeptide binding]; other site 1211025010167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1211025010168 active site 1211025010169 colicin V production protein; Provisional; Region: PRK10845 1211025010170 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1211025010171 cell division protein DedD; Provisional; Region: PRK11633 1211025010172 Sporulation related domain; Region: SPOR; pfam05036 1211025010173 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1211025010174 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1211025010175 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1211025010176 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1211025010177 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1211025010178 hypothetical protein; Provisional; Region: PRK10847 1211025010179 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1211025010180 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1211025010181 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1211025010182 dimerization interface 3.5A [polypeptide binding]; other site 1211025010183 active site 1211025010184 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1211025010185 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1211025010186 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1211025010187 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1211025010188 ligand binding site [chemical binding]; other site 1211025010189 NAD binding site [chemical binding]; other site 1211025010190 catalytic site [active] 1211025010191 homodimer interface [polypeptide binding]; other site 1211025010192 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1211025010193 putative transporter; Provisional; Region: PRK12382 1211025010194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025010195 putative substrate translocation pore; other site 1211025010196 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1211025010197 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1211025010198 dimer interface [polypeptide binding]; other site 1211025010199 active site 1211025010200 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1211025010201 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1211025010202 YfcL protein; Region: YfcL; pfam08891 1211025010203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1211025010204 hypothetical protein; Provisional; Region: PRK10621 1211025010205 Predicted permeases [General function prediction only]; Region: COG0730 1211025010206 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1211025010207 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1211025010208 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1211025010209 Tetramer interface [polypeptide binding]; other site 1211025010210 active site 1211025010211 FMN-binding site [chemical binding]; other site 1211025010212 HemK family putative methylases; Region: hemK_fam; TIGR00536 1211025010213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025010214 S-adenosylmethionine binding site [chemical binding]; other site 1211025010215 hypothetical protein; Provisional; Region: PRK04946 1211025010216 Smr domain; Region: Smr; pfam01713 1211025010217 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1211025010218 catalytic core [active] 1211025010219 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1211025010220 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1211025010221 substrate binding site [chemical binding]; other site 1211025010222 oxyanion hole (OAH) forming residues; other site 1211025010223 trimer interface [polypeptide binding]; other site 1211025010224 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1211025010225 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1211025010226 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1211025010227 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1211025010228 dimer interface [polypeptide binding]; other site 1211025010229 active site 1211025010230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1211025010231 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1211025010232 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1211025010233 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1211025010234 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1211025010235 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1211025010236 ImpA domain protein; Region: DUF3702; pfam12486 1211025010237 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1211025010238 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1211025010239 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1211025010240 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1211025010241 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1211025010242 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1211025010243 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1211025010244 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1211025010245 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1211025010246 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1211025010247 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1211025010248 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1211025010249 PAAR motif; Region: PAAR_motif; pfam05488 1211025010250 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1211025010251 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1211025010252 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1211025010253 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1211025010254 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1211025010255 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1211025010256 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1211025010257 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1211025010258 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1211025010259 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1211025010260 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1211025010261 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1211025010262 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1211025010263 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1211025010264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025010265 Walker A motif; other site 1211025010266 ATP binding site [chemical binding]; other site 1211025010267 Walker B motif; other site 1211025010268 arginine finger; other site 1211025010269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025010270 Walker A motif; other site 1211025010271 ATP binding site [chemical binding]; other site 1211025010272 Walker B motif; other site 1211025010273 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1211025010274 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1211025010275 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1211025010276 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1211025010277 ligand binding site [chemical binding]; other site 1211025010278 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1211025010279 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1211025010280 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1211025010281 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1211025010282 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1211025010283 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1211025010284 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1211025010285 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1211025010286 putative acyl-acceptor binding pocket; other site 1211025010287 aminotransferase; Validated; Region: PRK08175 1211025010288 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025010289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025010290 homodimer interface [polypeptide binding]; other site 1211025010291 catalytic residue [active] 1211025010292 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1211025010293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025010294 GAF domain; Region: GAF; pfam01590 1211025010295 Histidine kinase; Region: His_kinase; pfam06580 1211025010296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025010297 ATP binding site [chemical binding]; other site 1211025010298 Mg2+ binding site [ion binding]; other site 1211025010299 G-X-G motif; other site 1211025010300 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1211025010301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025010302 active site 1211025010303 phosphorylation site [posttranslational modification] 1211025010304 intermolecular recognition site; other site 1211025010305 dimerization interface [polypeptide binding]; other site 1211025010306 LytTr DNA-binding domain; Region: LytTR; pfam04397 1211025010307 glucokinase; Provisional; Region: glk; PRK00292 1211025010308 glucokinase, proteobacterial type; Region: glk; TIGR00749 1211025010309 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1211025010310 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1211025010311 Cl- selectivity filter; other site 1211025010312 Cl- binding residues [ion binding]; other site 1211025010313 pore gating glutamate residue; other site 1211025010314 dimer interface [polypeptide binding]; other site 1211025010315 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1211025010316 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1211025010317 dimer interface [polypeptide binding]; other site 1211025010318 PYR/PP interface [polypeptide binding]; other site 1211025010319 TPP binding site [chemical binding]; other site 1211025010320 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1211025010321 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1211025010322 TPP-binding site [chemical binding]; other site 1211025010323 dimer interface [polypeptide binding]; other site 1211025010324 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1211025010325 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1211025010326 active site 1211025010327 catalytic tetrad [active] 1211025010328 manganese transport protein MntH; Reviewed; Region: PRK00701 1211025010329 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1211025010330 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1211025010331 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1211025010332 Nucleoside recognition; Region: Gate; pfam07670 1211025010333 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1211025010334 MASE1; Region: MASE1; pfam05231 1211025010335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025010336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025010337 metal binding site [ion binding]; metal-binding site 1211025010338 active site 1211025010339 I-site; other site 1211025010340 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025010341 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1211025010342 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1211025010343 potential frameshift: common BLAST hit: gi|365971526|ref|YP_004953086.1| glutamyl-tRNA synthetase 1211025010344 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1211025010345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025010346 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1211025010347 putative dimerization interface [polypeptide binding]; other site 1211025010348 putative substrate binding pocket [chemical binding]; other site 1211025010349 nucleoside transporter; Region: 2A0110; TIGR00889 1211025010350 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1211025010351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025010352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025010353 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1211025010354 putative dimerization interface [polypeptide binding]; other site 1211025010355 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1211025010356 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1211025010357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1211025010358 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1211025010359 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1211025010360 nucleotide binding pocket [chemical binding]; other site 1211025010361 K-X-D-G motif; other site 1211025010362 catalytic site [active] 1211025010363 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1211025010364 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1211025010365 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1211025010366 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1211025010367 Dimer interface [polypeptide binding]; other site 1211025010368 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1211025010369 cell division protein ZipA; Provisional; Region: PRK03427 1211025010370 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1211025010371 FtsZ protein binding site [polypeptide binding]; other site 1211025010372 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1211025010373 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1211025010374 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1211025010375 dimer interface [polypeptide binding]; other site 1211025010376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025010377 catalytic residue [active] 1211025010378 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1211025010379 dimerization domain swap beta strand [polypeptide binding]; other site 1211025010380 regulatory protein interface [polypeptide binding]; other site 1211025010381 active site 1211025010382 regulatory phosphorylation site [posttranslational modification]; other site 1211025010383 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1211025010384 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1211025010385 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1211025010386 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1211025010387 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1211025010388 HPr interaction site; other site 1211025010389 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1211025010390 active site 1211025010391 phosphorylation site [posttranslational modification] 1211025010392 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1211025010393 dimer interface [polypeptide binding]; other site 1211025010394 pyridoxamine kinase; Validated; Region: PRK05756 1211025010395 pyridoxal binding site [chemical binding]; other site 1211025010396 ATP binding site [chemical binding]; other site 1211025010397 cysteine synthase B; Region: cysM; TIGR01138 1211025010398 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1211025010399 dimer interface [polypeptide binding]; other site 1211025010400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025010401 catalytic residue [active] 1211025010402 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1211025010403 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1211025010404 Walker A/P-loop; other site 1211025010405 ATP binding site [chemical binding]; other site 1211025010406 Q-loop/lid; other site 1211025010407 ABC transporter signature motif; other site 1211025010408 Walker B; other site 1211025010409 D-loop; other site 1211025010410 H-loop/switch region; other site 1211025010411 TOBE-like domain; Region: TOBE_3; pfam12857 1211025010412 sulfate transport protein; Provisional; Region: cysT; CHL00187 1211025010413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025010414 dimer interface [polypeptide binding]; other site 1211025010415 conserved gate region; other site 1211025010416 putative PBP binding loops; other site 1211025010417 ABC-ATPase subunit interface; other site 1211025010418 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1211025010419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025010420 dimer interface [polypeptide binding]; other site 1211025010421 conserved gate region; other site 1211025010422 putative PBP binding loops; other site 1211025010423 ABC-ATPase subunit interface; other site 1211025010424 thiosulfate transporter subunit; Provisional; Region: PRK10852 1211025010425 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1211025010426 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1211025010427 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1211025010428 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1211025010429 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1211025010430 putative acetyltransferase; Provisional; Region: PRK03624 1211025010431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025010432 Coenzyme A binding pocket [chemical binding]; other site 1211025010433 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1211025010434 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1211025010435 active site 1211025010436 metal binding site [ion binding]; metal-binding site 1211025010437 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1211025010438 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1211025010439 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1211025010440 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1211025010441 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1211025010442 putative NAD(P) binding site [chemical binding]; other site 1211025010443 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1211025010444 transaldolase-like protein; Provisional; Region: PTZ00411 1211025010445 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1211025010446 active site 1211025010447 dimer interface [polypeptide binding]; other site 1211025010448 catalytic residue [active] 1211025010449 transketolase; Reviewed; Region: PRK12753 1211025010450 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1211025010451 TPP-binding site [chemical binding]; other site 1211025010452 dimer interface [polypeptide binding]; other site 1211025010453 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1211025010454 PYR/PP interface [polypeptide binding]; other site 1211025010455 dimer interface [polypeptide binding]; other site 1211025010456 TPP binding site [chemical binding]; other site 1211025010457 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1211025010458 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1211025010459 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1211025010460 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1211025010461 dimer interface [polypeptide binding]; other site 1211025010462 ADP-ribose binding site [chemical binding]; other site 1211025010463 active site 1211025010464 nudix motif; other site 1211025010465 metal binding site [ion binding]; metal-binding site 1211025010466 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1211025010467 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1211025010468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025010469 dimerization interface [polypeptide binding]; other site 1211025010470 Histidine kinase; Region: HisKA_3; pfam07730 1211025010471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025010472 ATP binding site [chemical binding]; other site 1211025010473 Mg2+ binding site [ion binding]; other site 1211025010474 G-X-G motif; other site 1211025010475 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1211025010476 Protein export membrane protein; Region: SecD_SecF; cl14618 1211025010477 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1211025010478 ArsC family; Region: ArsC; pfam03960 1211025010479 putative catalytic residues [active] 1211025010480 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1211025010481 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1211025010482 metal binding site [ion binding]; metal-binding site 1211025010483 dimer interface [polypeptide binding]; other site 1211025010484 hypothetical protein; Provisional; Region: PRK13664 1211025010485 putative hydrolase; Provisional; Region: PRK11460 1211025010486 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1211025010487 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1211025010488 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 1211025010489 Helicase; Region: Helicase_RecD; pfam05127 1211025010490 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1211025010491 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1211025010492 Predicted metalloprotease [General function prediction only]; Region: COG2321 1211025010493 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1211025010494 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1211025010495 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1211025010496 ATP binding site [chemical binding]; other site 1211025010497 active site 1211025010498 substrate binding site [chemical binding]; other site 1211025010499 lipoprotein; Provisional; Region: PRK11679 1211025010500 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1211025010501 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1211025010502 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1211025010503 dimer interface [polypeptide binding]; other site 1211025010504 active site 1211025010505 catalytic residue [active] 1211025010506 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1211025010507 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1211025010508 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1211025010509 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1211025010510 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1211025010511 catalytic triad [active] 1211025010512 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1211025010513 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1211025010514 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1211025010515 Peptidase family M48; Region: Peptidase_M48; cl12018 1211025010516 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1211025010517 ArsC family; Region: ArsC; pfam03960 1211025010518 catalytic residues [active] 1211025010519 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 1211025010520 potential frameshift: common BLAST hit: gi|365971577|ref|YP_004953138.1| putative permease IIC component ywbA 1211025010521 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 1211025010522 active site 1211025010523 dimer interface [polypeptide binding]; other site 1211025010524 catalytic nucleophile [active] 1211025010525 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1211025010526 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1211025010527 interface (dimer of trimers) [polypeptide binding]; other site 1211025010528 Substrate-binding/catalytic site; other site 1211025010529 Zn-binding sites [ion binding]; other site 1211025010530 DNA replication initiation factor; Provisional; Region: PRK08084 1211025010531 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1211025010532 uracil transporter; Provisional; Region: PRK10720 1211025010533 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1211025010534 active site 1211025010535 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1211025010536 beta-galactosidase; Region: BGL; TIGR03356 1211025010537 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1211025010538 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1211025010539 dimerization interface [polypeptide binding]; other site 1211025010540 putative ATP binding site [chemical binding]; other site 1211025010541 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1211025010542 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1211025010543 active site 1211025010544 substrate binding site [chemical binding]; other site 1211025010545 cosubstrate binding site; other site 1211025010546 catalytic site [active] 1211025010547 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1211025010548 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1211025010549 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1211025010550 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1211025010551 putative active site [active] 1211025010552 catalytic site [active] 1211025010553 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1211025010554 domain interface [polypeptide binding]; other site 1211025010555 active site 1211025010556 catalytic site [active] 1211025010557 exopolyphosphatase; Provisional; Region: PRK10854 1211025010558 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1211025010559 MASE1; Region: MASE1; pfam05231 1211025010560 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025010561 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1211025010562 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025010563 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1211025010564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025010565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025010566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1211025010567 dimerization interface [polypeptide binding]; other site 1211025010568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025010569 putative substrate translocation pore; other site 1211025010570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025010571 Serine hydrolase; Region: Ser_hydrolase; cl17834 1211025010572 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1211025010573 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1211025010574 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1211025010575 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1211025010576 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1211025010577 substrate binding site [chemical binding]; other site 1211025010578 ATP binding site [chemical binding]; other site 1211025010579 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1211025010580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1211025010581 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025010582 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025010583 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025010584 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025010585 TM-ABC transporter signature motif; other site 1211025010586 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1211025010587 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1211025010588 Walker A/P-loop; other site 1211025010589 ATP binding site [chemical binding]; other site 1211025010590 Q-loop/lid; other site 1211025010591 ABC transporter signature motif; other site 1211025010592 Walker B; other site 1211025010593 D-loop; other site 1211025010594 H-loop/switch region; other site 1211025010595 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1211025010596 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1211025010597 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1211025010598 ligand binding site [chemical binding]; other site 1211025010599 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025010600 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025010601 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1211025010602 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1211025010603 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1211025010604 PYR/PP interface [polypeptide binding]; other site 1211025010605 dimer interface [polypeptide binding]; other site 1211025010606 TPP binding site [chemical binding]; other site 1211025010607 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1211025010608 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1211025010609 TPP-binding site; other site 1211025010610 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1211025010611 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1211025010612 tetrameric interface [polypeptide binding]; other site 1211025010613 NAD binding site [chemical binding]; other site 1211025010614 catalytic residues [active] 1211025010615 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1211025010616 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1211025010617 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1211025010618 putative active site [active] 1211025010619 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1211025010620 active site 1211025010621 GMP synthase; Reviewed; Region: guaA; PRK00074 1211025010622 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1211025010623 AMP/PPi binding site [chemical binding]; other site 1211025010624 candidate oxyanion hole; other site 1211025010625 catalytic triad [active] 1211025010626 potential glutamine specificity residues [chemical binding]; other site 1211025010627 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1211025010628 ATP Binding subdomain [chemical binding]; other site 1211025010629 Ligand Binding sites [chemical binding]; other site 1211025010630 Dimerization subdomain; other site 1211025010631 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1211025010632 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1211025010633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1211025010634 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1211025010635 active site 1211025010636 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1211025010637 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1211025010638 generic binding surface II; other site 1211025010639 generic binding surface I; other site 1211025010640 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1211025010641 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1211025010642 active site 1211025010643 Zn binding site [ion binding]; other site 1211025010644 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1211025010645 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025010646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025010647 putative substrate translocation pore; other site 1211025010648 POT family; Region: PTR2; cl17359 1211025010649 GTP-binding protein Der; Reviewed; Region: PRK00093 1211025010650 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1211025010651 G1 box; other site 1211025010652 GTP/Mg2+ binding site [chemical binding]; other site 1211025010653 Switch I region; other site 1211025010654 G2 box; other site 1211025010655 Switch II region; other site 1211025010656 G3 box; other site 1211025010657 G4 box; other site 1211025010658 G5 box; other site 1211025010659 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1211025010660 G1 box; other site 1211025010661 GTP/Mg2+ binding site [chemical binding]; other site 1211025010662 Switch I region; other site 1211025010663 G2 box; other site 1211025010664 G3 box; other site 1211025010665 Switch II region; other site 1211025010666 G4 box; other site 1211025010667 G5 box; other site 1211025010668 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1211025010669 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1211025010670 Trp docking motif [polypeptide binding]; other site 1211025010671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1211025010672 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1211025010673 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1211025010674 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1211025010675 dimer interface [polypeptide binding]; other site 1211025010676 motif 1; other site 1211025010677 active site 1211025010678 motif 2; other site 1211025010679 motif 3; other site 1211025010680 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1211025010681 anticodon binding site; other site 1211025010682 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1211025010683 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1211025010684 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1211025010685 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1211025010686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025010687 non-specific DNA binding site [nucleotide binding]; other site 1211025010688 salt bridge; other site 1211025010689 sequence-specific DNA binding site [nucleotide binding]; other site 1211025010690 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1211025010691 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1211025010692 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025010693 FeS/SAM binding site; other site 1211025010694 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1211025010695 active site 1211025010696 multimer interface [polypeptide binding]; other site 1211025010697 4Fe-4S binding domain; Region: Fer4; pfam00037 1211025010698 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1211025010699 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1211025010700 4Fe-4S binding domain; Region: Fer4; pfam00037 1211025010701 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1211025010702 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1211025010703 putative [Fe4-S4] binding site [ion binding]; other site 1211025010704 putative molybdopterin cofactor binding site [chemical binding]; other site 1211025010705 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1211025010706 putative molybdopterin cofactor binding site; other site 1211025010707 penicillin-binding protein 1C; Provisional; Region: PRK11240 1211025010708 Transglycosylase; Region: Transgly; pfam00912 1211025010709 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1211025010710 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1211025010711 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1211025010712 MG2 domain; Region: A2M_N; pfam01835 1211025010713 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1211025010714 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1211025010715 surface patch; other site 1211025010716 thioester region; other site 1211025010717 specificity defining residues; other site 1211025010718 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1211025010719 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1211025010720 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025010721 active site turn [active] 1211025010722 phosphorylation site [posttranslational modification] 1211025010723 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1211025010724 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1211025010725 NAD binding site [chemical binding]; other site 1211025010726 sugar binding site [chemical binding]; other site 1211025010727 divalent metal binding site [ion binding]; other site 1211025010728 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1211025010729 dimer interface [polypeptide binding]; other site 1211025010730 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1211025010731 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1211025010732 active site residue [active] 1211025010733 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1211025010734 active site residue [active] 1211025010735 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1211025010736 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1211025010737 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1211025010738 putative active site [active] 1211025010739 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1211025010740 aminopeptidase B; Provisional; Region: PRK05015 1211025010741 Peptidase; Region: DUF3663; pfam12404 1211025010742 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1211025010743 interface (dimer of trimers) [polypeptide binding]; other site 1211025010744 Substrate-binding/catalytic site; other site 1211025010745 Zn-binding sites [ion binding]; other site 1211025010746 hypothetical protein; Provisional; Region: PRK10721 1211025010747 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1211025010748 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1211025010749 catalytic loop [active] 1211025010750 iron binding site [ion binding]; other site 1211025010751 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1211025010752 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1211025010753 nucleotide binding site [chemical binding]; other site 1211025010754 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1211025010755 SBD interface [polypeptide binding]; other site 1211025010756 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1211025010757 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1211025010758 HSP70 interaction site [polypeptide binding]; other site 1211025010759 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1211025010760 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1211025010761 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1211025010762 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1211025010763 trimerization site [polypeptide binding]; other site 1211025010764 active site 1211025010765 cysteine desulfurase; Provisional; Region: PRK14012 1211025010766 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1211025010767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1211025010768 catalytic residue [active] 1211025010769 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1211025010770 Rrf2 family protein; Region: rrf2_super; TIGR00738 1211025010771 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1211025010772 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1211025010773 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1211025010774 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1211025010775 active site 1211025010776 dimerization interface [polypeptide binding]; other site 1211025010777 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1211025010778 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1211025010779 potential frameshift: common BLAST hit: gi|365971643|ref|YP_004953204.1| Stationary phase-inducible protein CsiE 1211025010780 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1211025010781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025010782 putative substrate translocation pore; other site 1211025010783 Predicted membrane protein [Function unknown]; Region: COG2259 1211025010784 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1211025010785 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1211025010786 dimer interface [polypeptide binding]; other site 1211025010787 active site 1211025010788 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1211025010789 folate binding site [chemical binding]; other site 1211025010790 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1211025010791 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1211025010792 heme-binding site [chemical binding]; other site 1211025010793 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1211025010794 FAD binding pocket [chemical binding]; other site 1211025010795 FAD binding motif [chemical binding]; other site 1211025010796 phosphate binding motif [ion binding]; other site 1211025010797 beta-alpha-beta structure motif; other site 1211025010798 NAD binding pocket [chemical binding]; other site 1211025010799 Heme binding pocket [chemical binding]; other site 1211025010800 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1211025010801 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1211025010802 response regulator GlrR; Provisional; Region: PRK15115 1211025010803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025010804 active site 1211025010805 phosphorylation site [posttranslational modification] 1211025010806 intermolecular recognition site; other site 1211025010807 dimerization interface [polypeptide binding]; other site 1211025010808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025010809 Walker A motif; other site 1211025010810 ATP binding site [chemical binding]; other site 1211025010811 Walker B motif; other site 1211025010812 arginine finger; other site 1211025010813 hypothetical protein; Provisional; Region: PRK10722 1211025010814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1211025010815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025010816 dimer interface [polypeptide binding]; other site 1211025010817 phosphorylation site [posttranslational modification] 1211025010818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025010819 ATP binding site [chemical binding]; other site 1211025010820 Mg2+ binding site [ion binding]; other site 1211025010821 G-X-G motif; other site 1211025010822 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1211025010823 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1211025010824 dimerization interface [polypeptide binding]; other site 1211025010825 ATP binding site [chemical binding]; other site 1211025010826 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1211025010827 dimerization interface [polypeptide binding]; other site 1211025010828 ATP binding site [chemical binding]; other site 1211025010829 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1211025010830 putative active site [active] 1211025010831 catalytic triad [active] 1211025010832 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1211025010833 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025010834 substrate binding pocket [chemical binding]; other site 1211025010835 membrane-bound complex binding site; other site 1211025010836 hinge residues; other site 1211025010837 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1211025010838 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1211025010839 catalytic residue [active] 1211025010840 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1211025010841 nucleoside/Zn binding site; other site 1211025010842 dimer interface [polypeptide binding]; other site 1211025010843 catalytic motif [active] 1211025010844 hypothetical protein; Provisional; Region: PRK11590 1211025010845 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1211025010846 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1211025010847 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025010848 active site turn [active] 1211025010849 phosphorylation site [posttranslational modification] 1211025010850 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1211025010851 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1211025010852 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1211025010853 putative active site [active] 1211025010854 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1211025010855 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1211025010856 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1211025010857 putative active site [active] 1211025010858 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1211025010859 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1211025010860 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1211025010861 active site 1211025010862 hydrophilic channel; other site 1211025010863 dimerization interface [polypeptide binding]; other site 1211025010864 catalytic residues [active] 1211025010865 active site lid [active] 1211025010866 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1211025010867 Recombination protein O N terminal; Region: RecO_N; pfam11967 1211025010868 Recombination protein O C terminal; Region: RecO_C; pfam02565 1211025010869 GTPase Era; Reviewed; Region: era; PRK00089 1211025010870 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1211025010871 G1 box; other site 1211025010872 GTP/Mg2+ binding site [chemical binding]; other site 1211025010873 Switch I region; other site 1211025010874 G2 box; other site 1211025010875 Switch II region; other site 1211025010876 G3 box; other site 1211025010877 G4 box; other site 1211025010878 G5 box; other site 1211025010879 KH domain; Region: KH_2; pfam07650 1211025010880 ribonuclease III; Reviewed; Region: rnc; PRK00102 1211025010881 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1211025010882 dimerization interface [polypeptide binding]; other site 1211025010883 active site 1211025010884 metal binding site [ion binding]; metal-binding site 1211025010885 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1211025010886 dsRNA binding site [nucleotide binding]; other site 1211025010887 signal peptidase I; Provisional; Region: PRK10861 1211025010888 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1211025010889 Catalytic site [active] 1211025010890 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1211025010891 GTP-binding protein LepA; Provisional; Region: PRK05433 1211025010892 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1211025010893 G1 box; other site 1211025010894 putative GEF interaction site [polypeptide binding]; other site 1211025010895 GTP/Mg2+ binding site [chemical binding]; other site 1211025010896 Switch I region; other site 1211025010897 G2 box; other site 1211025010898 G3 box; other site 1211025010899 Switch II region; other site 1211025010900 G4 box; other site 1211025010901 G5 box; other site 1211025010902 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1211025010903 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1211025010904 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1211025010905 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1211025010906 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1211025010907 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1211025010908 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1211025010909 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1211025010910 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1211025010911 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1211025010912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1211025010913 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1211025010914 DNA binding residues [nucleotide binding] 1211025010915 L-aspartate oxidase; Provisional; Region: PRK09077 1211025010916 L-aspartate oxidase; Provisional; Region: PRK06175 1211025010917 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1211025010918 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1211025010919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025010920 S-adenosylmethionine binding site [chemical binding]; other site 1211025010921 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1211025010922 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1211025010923 ATP binding site [chemical binding]; other site 1211025010924 Mg++ binding site [ion binding]; other site 1211025010925 motif III; other site 1211025010926 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025010927 nucleotide binding region [chemical binding]; other site 1211025010928 ATP-binding site [chemical binding]; other site 1211025010929 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1211025010930 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1211025010931 ligand binding site [chemical binding]; other site 1211025010932 active site 1211025010933 UGI interface [polypeptide binding]; other site 1211025010934 catalytic site [active] 1211025010935 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1211025010936 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1211025010937 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1211025010938 thioredoxin 2; Provisional; Region: PRK10996 1211025010939 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1211025010940 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1211025010941 catalytic residues [active] 1211025010942 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1211025010943 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1211025010944 CoA binding domain; Region: CoA_binding_2; pfam13380 1211025010945 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1211025010946 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1211025010947 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1211025010948 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1211025010949 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1211025010950 domain interface [polypeptide binding]; other site 1211025010951 putative active site [active] 1211025010952 catalytic site [active] 1211025010953 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1211025010954 domain interface [polypeptide binding]; other site 1211025010955 putative active site [active] 1211025010956 catalytic site [active] 1211025010957 lipoprotein; Provisional; Region: PRK10759 1211025010958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025010959 putative substrate translocation pore; other site 1211025010960 protein disaggregation chaperone; Provisional; Region: PRK10865 1211025010961 Clp amino terminal domain; Region: Clp_N; pfam02861 1211025010962 Clp amino terminal domain; Region: Clp_N; pfam02861 1211025010963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025010964 Walker A motif; other site 1211025010965 ATP binding site [chemical binding]; other site 1211025010966 Walker B motif; other site 1211025010967 arginine finger; other site 1211025010968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025010969 Walker A motif; other site 1211025010970 ATP binding site [chemical binding]; other site 1211025010971 Walker B motif; other site 1211025010972 arginine finger; other site 1211025010973 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1211025010974 hypothetical protein; Provisional; Region: PRK10723 1211025010975 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1211025010976 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1211025010977 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1211025010978 RNA binding surface [nucleotide binding]; other site 1211025010979 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1211025010980 active site 1211025010981 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1211025010982 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1211025010983 30S subunit binding site; other site 1211025010984 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1211025010985 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1211025010986 Prephenate dehydratase; Region: PDT; pfam00800 1211025010987 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1211025010988 putative L-Phe binding site [chemical binding]; other site 1211025010989 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1211025010990 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1211025010991 Chorismate mutase type II; Region: CM_2; cl00693 1211025010992 prephenate dehydrogenase; Validated; Region: PRK08507 1211025010993 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1211025010994 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1211025010995 lipoprotein; Provisional; Region: PRK11443 1211025010996 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 1211025010997 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1211025010998 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1211025010999 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025011000 metal binding site [ion binding]; metal-binding site 1211025011001 active site 1211025011002 I-site; other site 1211025011003 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1211025011004 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1211025011005 ligand binding site [chemical binding]; other site 1211025011006 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1211025011007 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1211025011008 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1211025011009 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1211025011010 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1211025011011 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1211025011012 RimM N-terminal domain; Region: RimM; pfam01782 1211025011013 PRC-barrel domain; Region: PRC; pfam05239 1211025011014 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1211025011015 signal recognition particle protein; Provisional; Region: PRK10867 1211025011016 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1211025011017 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1211025011018 P loop; other site 1211025011019 GTP binding site [chemical binding]; other site 1211025011020 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1211025011021 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1211025011022 hypothetical protein; Provisional; Region: PRK11573 1211025011023 Domain of unknown function DUF21; Region: DUF21; pfam01595 1211025011024 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1211025011025 Transporter associated domain; Region: CorC_HlyC; smart01091 1211025011026 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1211025011027 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1211025011028 dimer interface [polypeptide binding]; other site 1211025011029 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1211025011030 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1211025011031 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1211025011032 recombination and repair protein; Provisional; Region: PRK10869 1211025011033 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1211025011034 Walker A/P-loop; other site 1211025011035 ATP binding site [chemical binding]; other site 1211025011036 Q-loop/lid; other site 1211025011037 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1211025011038 ABC transporter signature motif; other site 1211025011039 Walker B; other site 1211025011040 D-loop; other site 1211025011041 H-loop/switch region; other site 1211025011042 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1211025011043 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1211025011044 hypothetical protein; Validated; Region: PRK01777 1211025011045 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1211025011046 putative coenzyme Q binding site [chemical binding]; other site 1211025011047 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1211025011048 SmpB-tmRNA interface; other site 1211025011049 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1211025011050 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1211025011051 tail protein; Provisional; Region: D; PHA02561 1211025011052 Phage protein U [General function prediction only]; Region: COG3499 1211025011053 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1211025011054 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1211025011055 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1211025011056 major tail tube protein; Provisional; Region: FII; PHA02600 1211025011057 major tail sheath protein; Provisional; Region: FI; PHA02560 1211025011058 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1211025011059 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1211025011060 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1211025011061 baseplate assembly protein; Provisional; Region: J; PHA02568 1211025011062 baseplate wedge subunit; Provisional; Region: W; PHA02516 1211025011063 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1211025011064 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1211025011065 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1211025011066 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1211025011067 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1211025011068 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1211025011069 catalytic residues [active] 1211025011070 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 1211025011071 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1211025011072 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1211025011073 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1211025011074 capsid protein; Provisional; Region: N; PHA02538 1211025011075 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1211025011076 terminase ATPase subunit; Provisional; Region: P; PHA02535 1211025011077 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1211025011078 portal vertex protein; Provisional; Region: Q; PHA02536 1211025011079 Phage portal protein; Region: Phage_portal; pfam04860 1211025011080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025011081 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1211025011082 non-specific DNA binding site [nucleotide binding]; other site 1211025011083 salt bridge; other site 1211025011084 sequence-specific DNA binding site [nucleotide binding]; other site 1211025011085 TIGR04255 family protein; Region: sporadTIGR04255 1211025011086 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1211025011087 DinI-like family; Region: DinI; pfam06183 1211025011088 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1211025011089 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1211025011090 DNA adenine methylase (dam); Region: dam; TIGR00571 1211025011091 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 1211025011092 DksA-like zinc finger domain containing protein; Region: PHA00080 1211025011093 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1211025011094 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 1211025011095 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 1211025011096 Predicted transcriptional regulator [Transcription]; Region: COG2932 1211025011097 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1211025011098 integrase; Provisional; Region: int; PHA02601 1211025011099 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 1211025011100 dimer interface [polypeptide binding]; other site 1211025011101 active site 1211025011102 catalytic residues [active] 1211025011103 Int/Topo IB signature motif; other site 1211025011104 YceI-like domain; Region: YceI; pfam04264 1211025011105 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1211025011106 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1211025011107 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1211025011108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1211025011109 DNA binding residues [nucleotide binding] 1211025011110 Chitin binding Peritrophin-A domain; Region: CBM_14; cl02629 1211025011111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1211025011112 binding surface 1211025011113 TPR motif; other site 1211025011114 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1211025011115 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1211025011116 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011117 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011118 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011119 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011120 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011121 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011122 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011123 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011124 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011125 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011126 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011127 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011128 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1211025011129 VCBS repeat; Region: VCBS_repeat; TIGR01965 1211025011130 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1211025011131 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1211025011132 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1211025011133 putative active site [active] 1211025011134 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1211025011135 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1211025011136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025011137 Walker A/P-loop; other site 1211025011138 ATP binding site [chemical binding]; other site 1211025011139 Q-loop/lid; other site 1211025011140 ABC transporter signature motif; other site 1211025011141 Walker B; other site 1211025011142 D-loop; other site 1211025011143 H-loop/switch region; other site 1211025011144 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1211025011145 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025011146 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025011147 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1211025011148 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1211025011149 Helix-turn-helix domain; Region: HTH_18; pfam12833 1211025011150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025011151 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1211025011152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1211025011153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025011154 homodimer interface [polypeptide binding]; other site 1211025011155 catalytic residue [active] 1211025011156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025011157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025011158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025011159 dimerization interface [polypeptide binding]; other site 1211025011160 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1211025011161 putative NAD(P) binding site [chemical binding]; other site 1211025011162 homodimer interface [polypeptide binding]; other site 1211025011163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025011164 S-adenosylmethionine binding site [chemical binding]; other site 1211025011165 putative deaminase; Validated; Region: PRK06846 1211025011166 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1211025011167 active site 1211025011168 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1211025011169 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1211025011170 putative substrate binding site [chemical binding]; other site 1211025011171 nucleotide binding site [chemical binding]; other site 1211025011172 nucleotide binding site [chemical binding]; other site 1211025011173 homodimer interface [polypeptide binding]; other site 1211025011174 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1211025011175 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1211025011176 CoA binding domain; Region: CoA_binding; pfam02629 1211025011177 CoA-ligase; Region: Ligase_CoA; pfam00549 1211025011178 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1211025011179 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1211025011180 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1211025011181 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1211025011182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025011183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025011184 dimerization interface [polypeptide binding]; other site 1211025011185 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1211025011186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1211025011187 dimerization interface [polypeptide binding]; other site 1211025011188 putative DNA binding site [nucleotide binding]; other site 1211025011189 putative Zn2+ binding site [ion binding]; other site 1211025011190 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1211025011191 active site residue [active] 1211025011192 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1211025011193 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1211025011194 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1211025011195 hypothetical protein; Provisional; Region: PRK10556 1211025011196 hypothetical protein; Provisional; Region: PRK10132 1211025011197 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1211025011198 catalytic residues [active] 1211025011199 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1211025011200 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1211025011201 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1211025011202 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1211025011203 active site 1211025011204 dimer interface [polypeptide binding]; other site 1211025011205 catalytic residues [active] 1211025011206 effector binding site; other site 1211025011207 R2 peptide binding site; other site 1211025011208 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1211025011209 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1211025011210 dimer interface [polypeptide binding]; other site 1211025011211 putative radical transfer pathway; other site 1211025011212 diiron center [ion binding]; other site 1211025011213 tyrosyl radical; other site 1211025011214 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1211025011215 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1211025011216 Walker A/P-loop; other site 1211025011217 ATP binding site [chemical binding]; other site 1211025011218 Q-loop/lid; other site 1211025011219 ABC transporter signature motif; other site 1211025011220 Walker B; other site 1211025011221 D-loop; other site 1211025011222 H-loop/switch region; other site 1211025011223 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1211025011224 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1211025011225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025011226 dimer interface [polypeptide binding]; other site 1211025011227 conserved gate region; other site 1211025011228 putative PBP binding loops; other site 1211025011229 ABC-ATPase subunit interface; other site 1211025011230 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1211025011231 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1211025011232 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1211025011233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011234 transcriptional repressor MprA; Provisional; Region: PRK10870 1211025011235 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1211025011236 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1211025011237 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025011238 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025011239 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1211025011240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011241 putative substrate translocation pore; other site 1211025011242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011243 2-isopropylmalate synthase; Validated; Region: PRK03739 1211025011244 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1211025011245 active site 1211025011246 catalytic residues [active] 1211025011247 metal binding site [ion binding]; metal-binding site 1211025011248 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1211025011249 Cupin domain; Region: Cupin_2; pfam07883 1211025011250 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1211025011251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025011252 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1211025011253 glutamate--cysteine ligase; Provisional; Region: PRK02107 1211025011254 Predicted membrane protein [Function unknown]; Region: COG1238 1211025011255 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1211025011256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025011257 motif II; other site 1211025011258 carbon storage regulator; Provisional; Region: PRK01712 1211025011259 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1211025011260 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1211025011261 motif 1; other site 1211025011262 active site 1211025011263 motif 2; other site 1211025011264 motif 3; other site 1211025011265 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1211025011266 DHHA1 domain; Region: DHHA1; pfam02272 1211025011267 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1211025011268 recombinase A; Provisional; Region: recA; PRK09354 1211025011269 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1211025011270 hexamer interface [polypeptide binding]; other site 1211025011271 Walker A motif; other site 1211025011272 ATP binding site [chemical binding]; other site 1211025011273 Walker B motif; other site 1211025011274 hypothetical protein; Validated; Region: PRK03661 1211025011275 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1211025011276 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1211025011277 metal binding site [ion binding]; metal-binding site 1211025011278 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1211025011279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025011280 ABC-ATPase subunit interface; other site 1211025011281 dimer interface [polypeptide binding]; other site 1211025011282 putative PBP binding regions; other site 1211025011283 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1211025011284 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1211025011285 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1211025011286 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1211025011287 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1211025011288 catalytic residue [active] 1211025011289 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1211025011290 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1211025011291 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1211025011292 Nucleoside recognition; Region: Gate; pfam07670 1211025011293 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1211025011294 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1211025011295 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1211025011296 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1211025011297 putative NAD(P) binding site [chemical binding]; other site 1211025011298 active site 1211025011299 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1211025011300 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1211025011301 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1211025011302 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1211025011303 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1211025011304 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1211025011305 putative active site [active] 1211025011306 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1211025011307 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1211025011308 GAF domain; Region: GAF; pfam01590 1211025011309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025011310 Walker A motif; other site 1211025011311 ATP binding site [chemical binding]; other site 1211025011312 Walker B motif; other site 1211025011313 arginine finger; other site 1211025011314 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1211025011315 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1211025011316 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1211025011317 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1211025011318 iron binding site [ion binding]; other site 1211025011319 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1211025011320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025011321 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1211025011322 potential frameshift: common BLAST hit: gi|365971816|ref|YP_004953377.1| carbamoyltransferase hypF 1211025011323 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1211025011324 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1211025011325 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025011326 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025011327 DNA binding site [nucleotide binding] 1211025011328 domain linker motif; other site 1211025011329 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1211025011330 dimerization interface (closed form) [polypeptide binding]; other site 1211025011331 ligand binding site [chemical binding]; other site 1211025011332 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1211025011333 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025011334 active site turn [active] 1211025011335 phosphorylation site [posttranslational modification] 1211025011336 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1211025011337 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1211025011338 beta-galactosidase; Region: BGL; TIGR03356 1211025011339 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1211025011340 nickel binding site [ion binding]; other site 1211025011341 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1211025011342 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1211025011343 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1211025011344 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1211025011345 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1211025011346 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1211025011347 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1211025011348 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1211025011349 NADH dehydrogenase; Region: NADHdh; cl00469 1211025011350 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1211025011351 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1211025011352 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1211025011353 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1211025011354 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1211025011355 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1211025011356 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1211025011357 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1211025011358 potential frameshift: common BLAST hit: gi|296104406|ref|YP_003614552.1| hydrogenase expression/formation protein HypD 1211025011359 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1211025011360 dimerization interface [polypeptide binding]; other site 1211025011361 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1211025011362 ATP binding site [chemical binding]; other site 1211025011363 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1211025011364 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1211025011365 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1211025011366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025011367 Walker A motif; other site 1211025011368 ATP binding site [chemical binding]; other site 1211025011369 Walker B motif; other site 1211025011370 arginine finger; other site 1211025011371 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1211025011372 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1211025011373 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1211025011374 intersubunit interface [polypeptide binding]; other site 1211025011375 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1211025011376 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025011377 dimer interface [polypeptide binding]; other site 1211025011378 putative PBP binding regions; other site 1211025011379 ABC-ATPase subunit interface; other site 1211025011380 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1211025011381 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1211025011382 Walker A/P-loop; other site 1211025011383 ATP binding site [chemical binding]; other site 1211025011384 Q-loop/lid; other site 1211025011385 ABC transporter signature motif; other site 1211025011386 Walker B; other site 1211025011387 D-loop; other site 1211025011388 H-loop/switch region; other site 1211025011389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025011390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011391 putative substrate translocation pore; other site 1211025011392 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1211025011393 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 1211025011394 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1211025011395 MutS domain I; Region: MutS_I; pfam01624 1211025011396 MutS domain II; Region: MutS_II; pfam05188 1211025011397 MutS domain III; Region: MutS_III; pfam05192 1211025011398 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1211025011399 Walker A/P-loop; other site 1211025011400 ATP binding site [chemical binding]; other site 1211025011401 Q-loop/lid; other site 1211025011402 ABC transporter signature motif; other site 1211025011403 Walker B; other site 1211025011404 D-loop; other site 1211025011405 H-loop/switch region; other site 1211025011406 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1211025011407 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1211025011408 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1211025011409 Flavoprotein; Region: Flavoprotein; pfam02441 1211025011410 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1211025011411 MarR family; Region: MarR; pfam01047 1211025011412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025011413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025011414 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1211025011415 putative effector binding pocket; other site 1211025011416 dimerization interface [polypeptide binding]; other site 1211025011417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025011419 putative substrate translocation pore; other site 1211025011420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1211025011421 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1211025011422 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1211025011423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1211025011424 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1211025011425 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1211025011426 DNA binding residues [nucleotide binding] 1211025011427 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1211025011428 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1211025011429 Peptidase family M23; Region: Peptidase_M23; pfam01551 1211025011430 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1211025011431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025011432 S-adenosylmethionine binding site [chemical binding]; other site 1211025011433 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1211025011434 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1211025011435 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1211025011436 Permutation of conserved domain; other site 1211025011437 active site 1211025011438 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1211025011439 homotrimer interaction site [polypeptide binding]; other site 1211025011440 zinc binding site [ion binding]; other site 1211025011441 CDP-binding sites; other site 1211025011442 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1211025011443 substrate binding site; other site 1211025011444 dimer interface; other site 1211025011445 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1211025011446 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1211025011447 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1211025011448 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1211025011449 ligand-binding site [chemical binding]; other site 1211025011450 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1211025011451 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1211025011452 CysD dimerization site [polypeptide binding]; other site 1211025011453 G1 box; other site 1211025011454 putative GEF interaction site [polypeptide binding]; other site 1211025011455 GTP/Mg2+ binding site [chemical binding]; other site 1211025011456 Switch I region; other site 1211025011457 G2 box; other site 1211025011458 G3 box; other site 1211025011459 Switch II region; other site 1211025011460 G4 box; other site 1211025011461 G5 box; other site 1211025011462 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1211025011463 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1211025011464 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1211025011465 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1211025011466 Active Sites [active] 1211025011467 siroheme synthase; Provisional; Region: cysG; PRK10637 1211025011468 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1211025011469 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1211025011470 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1211025011471 active site 1211025011472 SAM binding site [chemical binding]; other site 1211025011473 homodimer interface [polypeptide binding]; other site 1211025011474 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1211025011475 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1211025011476 metal binding site [ion binding]; metal-binding site 1211025011477 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1211025011478 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1211025011479 Active Sites [active] 1211025011480 sulfite reductase subunit beta; Provisional; Region: PRK13504 1211025011481 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1211025011482 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1211025011483 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1211025011484 Flavodoxin; Region: Flavodoxin_1; pfam00258 1211025011485 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1211025011486 FAD binding pocket [chemical binding]; other site 1211025011487 FAD binding motif [chemical binding]; other site 1211025011488 catalytic residues [active] 1211025011489 NAD binding pocket [chemical binding]; other site 1211025011490 phosphate binding motif [ion binding]; other site 1211025011491 beta-alpha-beta structure motif; other site 1211025011492 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1211025011493 active site 1211025011494 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1211025011495 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1211025011496 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1211025011497 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1211025011498 putative active site cavity [active] 1211025011499 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1211025011500 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1211025011501 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1211025011502 active site turn [active] 1211025011503 phosphorylation site [posttranslational modification] 1211025011504 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1211025011505 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1211025011506 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1211025011507 putative active site [active] 1211025011508 fatty acyl CoA reductases (FARs), extended (e) SDRs; Region: FAR-N_SDR_e; cd05236 1211025011509 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1211025011510 putative NAD(P) binding site [chemical binding]; other site 1211025011511 active site 1211025011512 putative substrate binding site [chemical binding]; other site 1211025011513 enolase; Provisional; Region: eno; PRK00077 1211025011514 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1211025011515 dimer interface [polypeptide binding]; other site 1211025011516 metal binding site [ion binding]; metal-binding site 1211025011517 substrate binding pocket [chemical binding]; other site 1211025011518 CTP synthetase; Validated; Region: pyrG; PRK05380 1211025011519 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1211025011520 Catalytic site [active] 1211025011521 active site 1211025011522 UTP binding site [chemical binding]; other site 1211025011523 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1211025011524 active site 1211025011525 putative oxyanion hole; other site 1211025011526 catalytic triad [active] 1211025011527 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1211025011528 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1211025011529 homodimer interface [polypeptide binding]; other site 1211025011530 metal binding site [ion binding]; metal-binding site 1211025011531 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1211025011532 homodimer interface [polypeptide binding]; other site 1211025011533 active site 1211025011534 putative chemical substrate binding site [chemical binding]; other site 1211025011535 metal binding site [ion binding]; metal-binding site 1211025011536 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1211025011537 HD domain; Region: HD_4; pfam13328 1211025011538 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1211025011539 synthetase active site [active] 1211025011540 NTP binding site [chemical binding]; other site 1211025011541 metal binding site [ion binding]; metal-binding site 1211025011542 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1211025011543 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1211025011544 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1211025011545 TRAM domain; Region: TRAM; pfam01938 1211025011546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1211025011547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025011548 S-adenosylmethionine binding site [chemical binding]; other site 1211025011549 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1211025011550 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1211025011551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025011552 dimerization interface [polypeptide binding]; other site 1211025011553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025011554 dimer interface [polypeptide binding]; other site 1211025011555 phosphorylation site [posttranslational modification] 1211025011556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025011557 ATP binding site [chemical binding]; other site 1211025011558 Mg2+ binding site [ion binding]; other site 1211025011559 G-X-G motif; other site 1211025011560 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1211025011561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025011562 active site 1211025011563 phosphorylation site [posttranslational modification] 1211025011564 intermolecular recognition site; other site 1211025011565 dimerization interface [polypeptide binding]; other site 1211025011566 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1211025011567 putative binding surface; other site 1211025011568 active site 1211025011569 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1211025011570 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1211025011571 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1211025011572 active site 1211025011573 tetramer interface [polypeptide binding]; other site 1211025011574 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1211025011575 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1211025011576 active site 1211025011577 tetramer interface [polypeptide binding]; other site 1211025011578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011579 D-galactonate transporter; Region: 2A0114; TIGR00893 1211025011580 putative substrate translocation pore; other site 1211025011581 flavodoxin; Provisional; Region: PRK08105 1211025011582 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1211025011583 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1211025011584 probable active site [active] 1211025011585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1211025011586 SecY interacting protein Syd; Provisional; Region: PRK04968 1211025011587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1211025011588 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1211025011589 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1211025011590 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1211025011591 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1211025011592 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1211025011593 serine transporter; Region: stp; TIGR00814 1211025011594 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1211025011595 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1211025011596 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1211025011597 flap endonuclease-like protein; Provisional; Region: PRK09482 1211025011598 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1211025011599 active site 1211025011600 metal binding site 1 [ion binding]; metal-binding site 1211025011601 putative 5' ssDNA interaction site; other site 1211025011602 metal binding site 3; metal-binding site 1211025011603 metal binding site 2 [ion binding]; metal-binding site 1211025011604 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1211025011605 putative DNA binding site [nucleotide binding]; other site 1211025011606 putative metal binding site [ion binding]; other site 1211025011607 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1211025011608 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1211025011609 hypothetical protein; Provisional; Region: PRK10873 1211025011610 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1211025011611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025011612 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1211025011613 dimerization interface [polypeptide binding]; other site 1211025011614 substrate binding pocket [chemical binding]; other site 1211025011615 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1211025011616 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1211025011617 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1211025011618 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1211025011619 catalytic residue [active] 1211025011620 Fe-S metabolism associated domain; Region: SufE; cl00951 1211025011621 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1211025011622 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1211025011623 putative ATP binding site [chemical binding]; other site 1211025011624 putative substrate interface [chemical binding]; other site 1211025011625 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1211025011626 MltA specific insert domain; Region: MltA; pfam03562 1211025011627 3D domain; Region: 3D; pfam06725 1211025011628 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1211025011629 AMIN domain; Region: AMIN; pfam11741 1211025011630 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1211025011631 active site 1211025011632 metal binding site [ion binding]; metal-binding site 1211025011633 N-acetylglutamate synthase; Validated; Region: PRK05279 1211025011634 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1211025011635 putative feedback inhibition sensing region; other site 1211025011636 putative nucleotide binding site [chemical binding]; other site 1211025011637 putative substrate binding site [chemical binding]; other site 1211025011638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025011639 Coenzyme A binding pocket [chemical binding]; other site 1211025011640 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1211025011641 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025011642 ATP binding site [chemical binding]; other site 1211025011643 putative Mg++ binding site [ion binding]; other site 1211025011644 Family description; Region: UvrD_C_2; pfam13538 1211025011645 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1211025011646 protease3; Provisional; Region: PRK15101 1211025011647 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1211025011648 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1211025011649 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1211025011650 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1211025011651 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1211025011652 hypothetical protein; Provisional; Region: PRK10332 1211025011653 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1211025011654 hypothetical protein; Provisional; Region: PRK11521 1211025011655 hypothetical protein; Provisional; Region: PRK10557 1211025011656 hypothetical protein; Provisional; Region: PRK10506 1211025011657 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1211025011658 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1211025011659 dimerization interface [polypeptide binding]; other site 1211025011660 active site 1211025011661 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1211025011662 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1211025011663 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1211025011664 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1211025011665 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1211025011666 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1211025011667 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1211025011668 putative active site [active] 1211025011669 Ap4A binding site [chemical binding]; other site 1211025011670 nudix motif; other site 1211025011671 putative metal binding site [ion binding]; other site 1211025011672 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1211025011673 putative DNA-binding cleft [nucleotide binding]; other site 1211025011674 putative DNA clevage site; other site 1211025011675 molecular lever; other site 1211025011676 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1211025011677 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1211025011678 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1211025011679 active site 1211025011680 catalytic tetrad [active] 1211025011681 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1211025011682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011683 putative substrate translocation pore; other site 1211025011684 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1211025011685 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1211025011686 putative acyl-acceptor binding pocket; other site 1211025011687 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1211025011688 acyl-activating enzyme (AAE) consensus motif; other site 1211025011689 putative AMP binding site [chemical binding]; other site 1211025011690 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1211025011691 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025011692 DNA binding site [nucleotide binding] 1211025011693 domain linker motif; other site 1211025011694 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1211025011695 dimerization interface (closed form) [polypeptide binding]; other site 1211025011696 ligand binding site [chemical binding]; other site 1211025011697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025011698 Coenzyme A binding pocket [chemical binding]; other site 1211025011699 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025011700 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025011701 DNA binding site [nucleotide binding] 1211025011702 domain linker motif; other site 1211025011703 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1211025011704 dimerization interface (closed form) [polypeptide binding]; other site 1211025011705 ligand binding site [chemical binding]; other site 1211025011706 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1211025011707 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1211025011708 active site 1211025011709 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1211025011710 substrate binding site [chemical binding]; other site 1211025011711 catalytic residues [active] 1211025011712 dimer interface [polypeptide binding]; other site 1211025011713 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1211025011714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025011715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025011716 dimerization interface [polypeptide binding]; other site 1211025011717 putative racemase; Provisional; Region: PRK10200 1211025011718 aspartate racemase; Region: asp_race; TIGR00035 1211025011719 LPS O-antigen length regulator; Provisional; Region: PRK10381 1211025011720 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1211025011721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011722 putative substrate translocation pore; other site 1211025011723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011724 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1211025011725 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1211025011726 NADP binding site [chemical binding]; other site 1211025011727 homodimer interface [polypeptide binding]; other site 1211025011728 active site 1211025011729 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1211025011730 putative acyltransferase; Provisional; Region: PRK05790 1211025011731 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1211025011732 dimer interface [polypeptide binding]; other site 1211025011733 active site 1211025011734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025011735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025011736 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1211025011737 dimerization interface [polypeptide binding]; other site 1211025011738 Predicted membrane protein [Function unknown]; Region: COG4125 1211025011739 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1211025011740 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1211025011741 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1211025011742 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1211025011743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025011744 Coenzyme A binding pocket [chemical binding]; other site 1211025011745 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1211025011746 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1211025011747 PAS domain; Region: PAS; smart00091 1211025011748 putative active site [active] 1211025011749 heme pocket [chemical binding]; other site 1211025011750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025011751 ATP binding site [chemical binding]; other site 1211025011752 Mg2+ binding site [ion binding]; other site 1211025011753 G-X-G motif; other site 1211025011754 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1211025011755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025011756 active site 1211025011757 phosphorylation site [posttranslational modification] 1211025011758 intermolecular recognition site; other site 1211025011759 dimerization interface [polypeptide binding]; other site 1211025011760 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1211025011761 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1211025011762 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1211025011763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025011764 dimer interface [polypeptide binding]; other site 1211025011765 conserved gate region; other site 1211025011766 ABC-ATPase subunit interface; other site 1211025011767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025011768 dimer interface [polypeptide binding]; other site 1211025011769 conserved gate region; other site 1211025011770 putative PBP binding loops; other site 1211025011771 ABC-ATPase subunit interface; other site 1211025011772 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1211025011773 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1211025011774 Walker A/P-loop; other site 1211025011775 ATP binding site [chemical binding]; other site 1211025011776 Q-loop/lid; other site 1211025011777 ABC transporter signature motif; other site 1211025011778 Walker B; other site 1211025011779 D-loop; other site 1211025011780 H-loop/switch region; other site 1211025011781 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1211025011782 ArsC family; Region: ArsC; pfam03960 1211025011783 catalytic residues [active] 1211025011784 arsenical pump membrane protein; Provisional; Region: PRK15445 1211025011785 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1211025011786 transmembrane helices; other site 1211025011787 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1211025011788 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1211025011789 P loop; other site 1211025011790 Nucleotide binding site [chemical binding]; other site 1211025011791 DTAP/Switch II; other site 1211025011792 Switch I; other site 1211025011793 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1211025011794 P loop; other site 1211025011795 Nucleotide binding site [chemical binding]; other site 1211025011796 DTAP/Switch II; other site 1211025011797 Switch I; other site 1211025011798 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1211025011799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1211025011800 dimerization interface [polypeptide binding]; other site 1211025011801 putative DNA binding site [nucleotide binding]; other site 1211025011802 putative Zn2+ binding site [ion binding]; other site 1211025011803 YecR-like lipoprotein; Region: YecR; pfam13992 1211025011804 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1211025011805 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1211025011806 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1211025011807 active site 1211025011808 DNA binding site [nucleotide binding] 1211025011809 Int/Topo IB signature motif; other site 1211025011810 YecR-like lipoprotein; Region: YecR; pfam13992 1211025011811 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1211025011812 putative switch regulator; other site 1211025011813 non-specific DNA interactions [nucleotide binding]; other site 1211025011814 DNA binding site [nucleotide binding] 1211025011815 sequence specific DNA binding site [nucleotide binding]; other site 1211025011816 putative cAMP binding site [chemical binding]; other site 1211025011817 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1211025011818 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1211025011819 pyruvate, phosphate dikinase; Region: pyru_phos_dikin; TIGR01828 1211025011820 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1211025011821 Peptidase family M23; Region: Peptidase_M23; pfam01551 1211025011822 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1211025011823 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1211025011824 active site 1211025011825 metal binding site [ion binding]; metal-binding site 1211025011826 nudix motif; other site 1211025011827 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1211025011828 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1211025011829 dimer interface [polypeptide binding]; other site 1211025011830 putative anticodon binding site; other site 1211025011831 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1211025011832 motif 1; other site 1211025011833 active site 1211025011834 motif 2; other site 1211025011835 motif 3; other site 1211025011836 peptide chain release factor 2; Provisional; Region: PRK08787 1211025011837 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1211025011838 RF-1 domain; Region: RF-1; pfam00472 1211025011839 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1211025011840 DHH family; Region: DHH; pfam01368 1211025011841 DHHA1 domain; Region: DHHA1; pfam02272 1211025011842 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1211025011843 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1211025011844 dimerization domain [polypeptide binding]; other site 1211025011845 dimer interface [polypeptide binding]; other site 1211025011846 catalytic residues [active] 1211025011847 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1211025011848 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1211025011849 active site 1211025011850 Int/Topo IB signature motif; other site 1211025011851 flavodoxin FldB; Provisional; Region: PRK12359 1211025011852 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1211025011853 hypothetical protein; Provisional; Region: PRK10878 1211025011854 putative global regulator; Reviewed; Region: PRK09559 1211025011855 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1211025011856 hemolysin; Provisional; Region: PRK15087 1211025011857 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1211025011858 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1211025011859 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1211025011860 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1211025011861 putative active site [active] 1211025011862 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1211025011863 beta-galactosidase; Region: BGL; TIGR03356 1211025011864 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1211025011865 classical (c) SDRs; Region: SDR_c; cd05233 1211025011866 NAD(P) binding site [chemical binding]; other site 1211025011867 active site 1211025011868 glycine dehydrogenase; Provisional; Region: PRK05367 1211025011869 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1211025011870 tetramer interface [polypeptide binding]; other site 1211025011871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025011872 catalytic residue [active] 1211025011873 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1211025011874 tetramer interface [polypeptide binding]; other site 1211025011875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025011876 catalytic residue [active] 1211025011877 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1211025011878 lipoyl attachment site [posttranslational modification]; other site 1211025011879 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1211025011880 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1211025011881 oxidoreductase; Provisional; Region: PRK08013 1211025011882 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1211025011883 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1211025011884 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1211025011885 proline aminopeptidase P II; Provisional; Region: PRK10879 1211025011886 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1211025011887 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1211025011888 active site 1211025011889 hypothetical protein; Reviewed; Region: PRK01736 1211025011890 Z-ring-associated protein; Provisional; Region: PRK10972 1211025011891 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1211025011892 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1211025011893 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1211025011894 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1211025011895 ligand binding site [chemical binding]; other site 1211025011896 NAD binding site [chemical binding]; other site 1211025011897 tetramer interface [polypeptide binding]; other site 1211025011898 catalytic site [active] 1211025011899 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1211025011900 L-serine binding site [chemical binding]; other site 1211025011901 ACT domain interface; other site 1211025011902 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1211025011903 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1211025011904 active site 1211025011905 dimer interface [polypeptide binding]; other site 1211025011906 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1211025011907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025011908 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1211025011909 putative dimerization interface [polypeptide binding]; other site 1211025011910 oxidative stress defense protein; Provisional; Region: PRK11087 1211025011911 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1211025011912 arginine exporter protein; Provisional; Region: PRK09304 1211025011913 mechanosensitive channel MscS; Provisional; Region: PRK10334 1211025011914 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1211025011915 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1211025011916 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1211025011917 active site 1211025011918 intersubunit interface [polypeptide binding]; other site 1211025011919 zinc binding site [ion binding]; other site 1211025011920 Na+ binding site [ion binding]; other site 1211025011921 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1211025011922 Phosphoglycerate kinase; Region: PGK; pfam00162 1211025011923 substrate binding site [chemical binding]; other site 1211025011924 hinge regions; other site 1211025011925 ADP binding site [chemical binding]; other site 1211025011926 catalytic site [active] 1211025011927 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1211025011928 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1211025011929 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1211025011930 transketolase; Reviewed; Region: PRK12753 1211025011931 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1211025011932 TPP-binding site [chemical binding]; other site 1211025011933 dimer interface [polypeptide binding]; other site 1211025011934 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1211025011935 PYR/PP interface [polypeptide binding]; other site 1211025011936 dimer interface [polypeptide binding]; other site 1211025011937 TPP binding site [chemical binding]; other site 1211025011938 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1211025011939 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1211025011940 outer membrane porin, OprD family; Region: OprD; pfam03573 1211025011941 hypothetical protein; Provisional; Region: PRK07064 1211025011942 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1211025011943 PYR/PP interface [polypeptide binding]; other site 1211025011944 dimer interface [polypeptide binding]; other site 1211025011945 TPP binding site [chemical binding]; other site 1211025011946 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1211025011947 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1211025011948 TPP-binding site [chemical binding]; other site 1211025011949 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1211025011950 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1211025011951 NAD(P) binding site [chemical binding]; other site 1211025011952 catalytic residues [active] 1211025011953 L-aspartate dehydrogenase; Provisional; Region: PRK13303 1211025011954 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1211025011955 Domain of unknown function DUF108; Region: DUF108; pfam01958 1211025011956 short chain dehydrogenase; Provisional; Region: PRK07062 1211025011957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1211025011958 NAD(P) binding site [chemical binding]; other site 1211025011959 active site 1211025011960 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1211025011961 Cupin domain; Region: Cupin_2; pfam07883 1211025011962 D-galactonate transporter; Region: 2A0114; TIGR00893 1211025011963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011964 putative substrate translocation pore; other site 1211025011965 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1211025011966 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025011967 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1211025011968 active site 1211025011969 metal binding site [ion binding]; metal-binding site 1211025011970 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1211025011971 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1211025011972 putative active site [active] 1211025011973 putative metal binding site [ion binding]; other site 1211025011974 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1211025011975 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1211025011976 Bacterial transcriptional regulator; Region: IclR; pfam01614 1211025011977 short chain dehydrogenase; Provisional; Region: PRK12939 1211025011978 classical (c) SDRs; Region: SDR_c; cd05233 1211025011979 NAD(P) binding site [chemical binding]; other site 1211025011980 active site 1211025011981 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1211025011982 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1211025011983 [2Fe-2S] cluster binding site [ion binding]; other site 1211025011984 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1211025011985 hydrophobic ligand binding site; other site 1211025011986 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1211025011987 [2Fe-2S] cluster binding site [ion binding]; other site 1211025011988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025011989 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1211025011990 putative substrate translocation pore; other site 1211025011991 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1211025011992 agmatinase; Region: agmatinase; TIGR01230 1211025011993 oligomer interface [polypeptide binding]; other site 1211025011994 putative active site [active] 1211025011995 Mn binding site [ion binding]; other site 1211025011996 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1211025011997 putative chaperone protein EcpD; Provisional; Region: PRK09926 1211025011998 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025011999 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025012000 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1211025012001 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025012002 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025012003 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025012004 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1211025012005 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1211025012006 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1211025012007 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1211025012008 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1211025012009 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1211025012010 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1211025012011 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1211025012012 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1211025012013 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1211025012014 dimer interface [polypeptide binding]; other site 1211025012015 active site 1211025012016 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1211025012017 catalytic residues [active] 1211025012018 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1211025012019 Virulence promoting factor; Region: YqgB; pfam11036 1211025012020 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 1211025012021 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1211025012022 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1211025012023 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1211025012024 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1211025012025 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1211025012026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025012027 putative substrate translocation pore; other site 1211025012028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025012029 hypothetical protein; Provisional; Region: PRK04860 1211025012030 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1211025012031 DNA-specific endonuclease I; Provisional; Region: PRK15137 1211025012032 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1211025012033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1211025012034 RNA methyltransferase, RsmE family; Region: TIGR00046 1211025012035 glutathione synthetase; Provisional; Region: PRK05246 1211025012036 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1211025012037 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1211025012038 hypothetical protein; Validated; Region: PRK00228 1211025012039 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1211025012040 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1211025012041 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1211025012042 Walker A motif; other site 1211025012043 ATP binding site [chemical binding]; other site 1211025012044 Walker B motif; other site 1211025012045 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1211025012046 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1211025012047 catalytic residue [active] 1211025012048 YGGT family; Region: YGGT; pfam02325 1211025012049 YGGT family; Region: YGGT; pfam02325 1211025012050 hypothetical protein; Validated; Region: PRK05090 1211025012051 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1211025012052 active site 1211025012053 dimerization interface [polypeptide binding]; other site 1211025012054 HemN family oxidoreductase; Provisional; Region: PRK05660 1211025012055 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025012056 FeS/SAM binding site; other site 1211025012057 HemN C-terminal domain; Region: HemN_C; pfam06969 1211025012058 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1211025012059 putative active site [active] 1211025012060 hypothetical protein; Provisional; Region: PRK10626 1211025012061 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1211025012062 hypothetical protein; Provisional; Region: PRK11702 1211025012063 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1211025012064 adenine DNA glycosylase; Provisional; Region: PRK10880 1211025012065 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1211025012066 minor groove reading motif; other site 1211025012067 helix-hairpin-helix signature motif; other site 1211025012068 substrate binding pocket [chemical binding]; other site 1211025012069 active site 1211025012070 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1211025012071 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1211025012072 DNA binding and oxoG recognition site [nucleotide binding] 1211025012073 oxidative damage protection protein; Provisional; Region: PRK05408 1211025012074 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1211025012075 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1211025012076 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1211025012077 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1211025012078 catalytic residue [active] 1211025012079 nucleoside transporter; Region: 2A0110; TIGR00889 1211025012080 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1211025012081 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1211025012082 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1211025012083 Coenzyme A transferase; Region: CoA_trans; cl17247 1211025012084 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1211025012085 citrate lyase subunit gamma; Provisional; Region: PRK13253 1211025012086 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1211025012087 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1211025012088 putative active site [active] 1211025012089 (T/H)XGH motif; other site 1211025012090 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1211025012091 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1211025012092 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1211025012093 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1211025012094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025012095 putative active site [active] 1211025012096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025012097 ATP binding site [chemical binding]; other site 1211025012098 Mg2+ binding site [ion binding]; other site 1211025012099 G-X-G motif; other site 1211025012100 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1211025012101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025012102 active site 1211025012103 phosphorylation site [posttranslational modification] 1211025012104 intermolecular recognition site; other site 1211025012105 dimerization interface [polypeptide binding]; other site 1211025012106 Transcriptional regulator; Region: CitT; pfam12431 1211025012107 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1211025012108 ornithine decarboxylase; Provisional; Region: PRK13578 1211025012109 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1211025012110 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1211025012111 homodimer interface [polypeptide binding]; other site 1211025012112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025012113 catalytic residue [active] 1211025012114 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1211025012115 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1211025012116 Protein of unknown function (DUF523); Region: DUF523; cl00733 1211025012117 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1211025012118 DNA binding residues [nucleotide binding] 1211025012119 dimerization interface [polypeptide binding]; other site 1211025012120 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1211025012121 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1211025012122 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1211025012123 putative active site [active] 1211025012124 putative metal binding site [ion binding]; other site 1211025012125 N-glycosyltransferase; Provisional; Region: PRK11204 1211025012126 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1211025012127 DXD motif; other site 1211025012128 PgaD-like protein; Region: PgaD; cl14676 1211025012129 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1211025012130 CHAP domain; Region: CHAP; pfam05257 1211025012131 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1211025012132 putative S-transferase; Provisional; Region: PRK11752 1211025012133 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1211025012134 C-terminal domain interface [polypeptide binding]; other site 1211025012135 GSH binding site (G-site) [chemical binding]; other site 1211025012136 dimer interface [polypeptide binding]; other site 1211025012137 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1211025012138 dimer interface [polypeptide binding]; other site 1211025012139 N-terminal domain interface [polypeptide binding]; other site 1211025012140 active site 1211025012141 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1211025012142 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1211025012143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025012144 dimerization interface [polypeptide binding]; other site 1211025012145 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1211025012146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025012147 dimer interface [polypeptide binding]; other site 1211025012148 putative CheW interface [polypeptide binding]; other site 1211025012149 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1211025012150 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1211025012151 active site 1211025012152 catalytic tetrad [active] 1211025012153 hypothetical protein; Provisional; Region: PRK05208 1211025012154 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1211025012155 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1211025012156 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1211025012157 cystathionine beta-lyase; Provisional; Region: PRK08114 1211025012158 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1211025012159 homodimer interface [polypeptide binding]; other site 1211025012160 substrate-cofactor binding pocket; other site 1211025012161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025012162 catalytic residue [active] 1211025012163 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1211025012164 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1211025012165 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1211025012166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025012167 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1211025012168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025012169 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1211025012170 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1211025012171 dimer interface [polypeptide binding]; other site 1211025012172 active site 1211025012173 metal binding site [ion binding]; metal-binding site 1211025012174 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1211025012175 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1211025012176 active site 1211025012177 catalytic tetrad [active] 1211025012178 hypothetical protein; Provisional; Region: PRK01254 1211025012179 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1211025012180 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1211025012181 Cation transport protein; Region: TrkH; cl17365 1211025012182 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1211025012183 FtsI repressor; Provisional; Region: PRK10883 1211025012184 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1211025012185 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1211025012186 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1211025012187 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1211025012188 putative acyl-acceptor binding pocket; other site 1211025012189 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1211025012190 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1211025012191 CAP-like domain; other site 1211025012192 active site 1211025012193 primary dimer interface [polypeptide binding]; other site 1211025012194 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1211025012195 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1211025012196 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1211025012197 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1211025012198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025012199 active site 1211025012200 phosphorylation site [posttranslational modification] 1211025012201 intermolecular recognition site; other site 1211025012202 dimerization interface [polypeptide binding]; other site 1211025012203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025012204 DNA binding site [nucleotide binding] 1211025012205 sensor protein QseC; Provisional; Region: PRK10337 1211025012206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025012207 dimer interface [polypeptide binding]; other site 1211025012208 phosphorylation site [posttranslational modification] 1211025012209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025012210 ATP binding site [chemical binding]; other site 1211025012211 Mg2+ binding site [ion binding]; other site 1211025012212 G-X-G motif; other site 1211025012213 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1211025012214 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1211025012215 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1211025012216 BON domain; Region: BON; pfam04972 1211025012217 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1211025012218 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1211025012219 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1211025012220 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1211025012221 putative active site [active] 1211025012222 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1211025012223 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1211025012224 intersubunit interface [polypeptide binding]; other site 1211025012225 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1211025012226 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025012227 ABC-ATPase subunit interface; other site 1211025012228 dimer interface [polypeptide binding]; other site 1211025012229 putative PBP binding regions; other site 1211025012230 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1211025012231 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1211025012232 ABC-ATPase subunit interface; other site 1211025012233 dimer interface [polypeptide binding]; other site 1211025012234 putative PBP binding regions; other site 1211025012235 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1211025012236 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1211025012237 Walker A/P-loop; other site 1211025012238 ATP binding site [chemical binding]; other site 1211025012239 Q-loop/lid; other site 1211025012240 ABC transporter signature motif; other site 1211025012241 Walker B; other site 1211025012242 D-loop; other site 1211025012243 H-loop/switch region; other site 1211025012244 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1211025012245 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025012246 N-terminal plug; other site 1211025012247 ligand-binding site [chemical binding]; other site 1211025012248 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1211025012249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025012250 ATP binding site [chemical binding]; other site 1211025012251 Mg2+ binding site [ion binding]; other site 1211025012252 G-X-G motif; other site 1211025012253 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1211025012254 anchoring element; other site 1211025012255 dimer interface [polypeptide binding]; other site 1211025012256 ATP binding site [chemical binding]; other site 1211025012257 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1211025012258 active site 1211025012259 metal binding site [ion binding]; metal-binding site 1211025012260 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1211025012261 esterase YqiA; Provisional; Region: PRK11071 1211025012262 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1211025012263 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1211025012264 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1211025012265 active site 1211025012266 metal binding site [ion binding]; metal-binding site 1211025012267 hexamer interface [polypeptide binding]; other site 1211025012268 putative dehydrogenase; Provisional; Region: PRK11039 1211025012269 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1211025012270 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1211025012271 dimer interface [polypeptide binding]; other site 1211025012272 ADP-ribose binding site [chemical binding]; other site 1211025012273 active site 1211025012274 nudix motif; other site 1211025012275 metal binding site [ion binding]; metal-binding site 1211025012276 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1211025012277 hypothetical protein; Provisional; Region: PRK11653 1211025012278 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1211025012279 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1211025012280 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1211025012281 putative active site [active] 1211025012282 metal binding site [ion binding]; metal-binding site 1211025012283 Fimbrial protein; Region: Fimbrial; cl01416 1211025012284 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1211025012285 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025012286 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025012287 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025012288 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1211025012289 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025012290 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025012291 Fimbrial protein; Region: Fimbrial; pfam00419 1211025012292 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1211025012293 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1211025012294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1211025012295 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1211025012296 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1211025012297 putative ribose interaction site [chemical binding]; other site 1211025012298 putative ADP binding site [chemical binding]; other site 1211025012299 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1211025012300 active site 1211025012301 nucleotide binding site [chemical binding]; other site 1211025012302 HIGH motif; other site 1211025012303 KMSKS motif; other site 1211025012304 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1211025012305 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1211025012306 metal binding triad; other site 1211025012307 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1211025012308 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1211025012309 metal binding triad; other site 1211025012310 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1211025012311 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1211025012312 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1211025012313 putative active site [active] 1211025012314 putative metal binding residues [ion binding]; other site 1211025012315 signature motif; other site 1211025012316 putative triphosphate binding site [ion binding]; other site 1211025012317 CHAD domain; Region: CHAD; pfam05235 1211025012318 SH3 domain-containing protein; Provisional; Region: PRK10884 1211025012319 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1211025012320 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1211025012321 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1211025012322 active site 1211025012323 NTP binding site [chemical binding]; other site 1211025012324 metal binding triad [ion binding]; metal-binding site 1211025012325 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1211025012326 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1211025012327 Zn2+ binding site [ion binding]; other site 1211025012328 Mg2+ binding site [ion binding]; other site 1211025012329 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1211025012330 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1211025012331 homooctamer interface [polypeptide binding]; other site 1211025012332 active site 1211025012333 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1211025012334 UreD urease accessory protein; Region: UreD; cl00530 1211025012335 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1211025012336 alpha-gamma subunit interface [polypeptide binding]; other site 1211025012337 beta-gamma subunit interface [polypeptide binding]; other site 1211025012338 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1211025012339 gamma-beta subunit interface [polypeptide binding]; other site 1211025012340 alpha-beta subunit interface [polypeptide binding]; other site 1211025012341 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1211025012342 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1211025012343 subunit interactions [polypeptide binding]; other site 1211025012344 active site 1211025012345 flap region; other site 1211025012346 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1211025012347 UreE urease accessory protein, N-terminal domain; Region: UreE_N; smart00988 1211025012348 UreE urease accessory protein, C-terminal domain; Region: UreE_C; pfam05194 1211025012349 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1211025012350 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1211025012351 UreF; Region: UreF; pfam01730 1211025012352 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1211025012353 UGMP family protein; Validated; Region: PRK09604 1211025012354 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1211025012355 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1211025012356 DNA primase; Validated; Region: dnaG; PRK05667 1211025012357 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1211025012358 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1211025012359 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1211025012360 active site 1211025012361 metal binding site [ion binding]; metal-binding site 1211025012362 interdomain interaction site; other site 1211025012363 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1211025012364 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1211025012365 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1211025012366 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1211025012367 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1211025012368 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1211025012369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1211025012370 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1211025012371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1211025012372 DNA binding residues [nucleotide binding] 1211025012373 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1211025012374 active site 1211025012375 SUMO-1 interface [polypeptide binding]; other site 1211025012376 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1211025012377 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1211025012378 active site 1211025012379 NTP binding site [chemical binding]; other site 1211025012380 nucleic acid binding site [nucleotide binding]; other site 1211025012381 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1211025012382 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 1211025012383 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1211025012384 Short C-terminal domain; Region: SHOCT; pfam09851 1211025012385 integrase; Provisional; Region: int; PHA02601 1211025012386 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1211025012387 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1211025012388 HSP70 interaction site [polypeptide binding]; other site 1211025012389 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1211025012390 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1211025012391 FAD binding pocket [chemical binding]; other site 1211025012392 FAD binding motif [chemical binding]; other site 1211025012393 phosphate binding motif [ion binding]; other site 1211025012394 NAD binding pocket [chemical binding]; other site 1211025012395 Predicted transcriptional regulators [Transcription]; Region: COG1695 1211025012396 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1211025012397 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1211025012398 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1211025012399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025012400 dimerization interface [polypeptide binding]; other site 1211025012401 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025012402 dimer interface [polypeptide binding]; other site 1211025012403 putative CheW interface [polypeptide binding]; other site 1211025012404 PAS fold; Region: PAS_3; pfam08447 1211025012405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025012406 putative active site [active] 1211025012407 heme pocket [chemical binding]; other site 1211025012408 HAMP domain; Region: HAMP; pfam00672 1211025012409 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1211025012410 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1211025012411 dimer interface [polypeptide binding]; other site 1211025012412 putative CheW interface [polypeptide binding]; other site 1211025012413 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1211025012414 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1211025012415 inhibitor-cofactor binding pocket; inhibition site 1211025012416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025012417 catalytic residue [active] 1211025012418 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1211025012419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025012420 non-specific DNA binding site [nucleotide binding]; other site 1211025012421 salt bridge; other site 1211025012422 sequence-specific DNA binding site [nucleotide binding]; other site 1211025012423 Cupin domain; Region: Cupin_2; pfam07883 1211025012424 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1211025012425 B3/4 domain; Region: B3_4; pfam03483 1211025012426 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1211025012427 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1211025012428 inhibitor site; inhibition site 1211025012429 active site 1211025012430 dimer interface [polypeptide binding]; other site 1211025012431 catalytic residue [active] 1211025012432 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1211025012433 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1211025012434 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1211025012435 putative active site; other site 1211025012436 catalytic residue [active] 1211025012437 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1211025012438 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1211025012439 ligand binding site [chemical binding]; other site 1211025012440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025012441 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025012442 TM-ABC transporter signature motif; other site 1211025012443 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1211025012444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1211025012445 TM-ABC transporter signature motif; other site 1211025012446 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1211025012447 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1211025012448 Walker A/P-loop; other site 1211025012449 ATP binding site [chemical binding]; other site 1211025012450 Q-loop/lid; other site 1211025012451 ABC transporter signature motif; other site 1211025012452 Walker B; other site 1211025012453 D-loop; other site 1211025012454 H-loop/switch region; other site 1211025012455 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1211025012456 transcriptional regulator LsrR; Provisional; Region: PRK15418 1211025012457 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1211025012458 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1211025012459 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1211025012460 putative N- and C-terminal domain interface [polypeptide binding]; other site 1211025012461 putative active site [active] 1211025012462 putative MgATP binding site [chemical binding]; other site 1211025012463 catalytic site [active] 1211025012464 metal binding site [ion binding]; metal-binding site 1211025012465 putative carbohydrate binding site [chemical binding]; other site 1211025012466 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1211025012467 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1211025012468 active site 1211025012469 FMN binding site [chemical binding]; other site 1211025012470 2,4-decadienoyl-CoA binding site; other site 1211025012471 catalytic residue [active] 1211025012472 4Fe-4S cluster binding site [ion binding]; other site 1211025012473 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1211025012474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1211025012475 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1211025012476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025012477 S-adenosylmethionine binding site [chemical binding]; other site 1211025012478 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1211025012479 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1211025012480 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1211025012481 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1211025012482 serine/threonine transporter SstT; Provisional; Region: PRK13628 1211025012483 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1211025012484 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1211025012485 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1211025012486 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1211025012487 Glucuronate isomerase; Region: UxaC; pfam02614 1211025012488 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1211025012489 D-galactonate transporter; Region: 2A0114; TIGR00893 1211025012490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025012491 putative substrate translocation pore; other site 1211025012492 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1211025012493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025012494 DNA-binding site [nucleotide binding]; DNA binding site 1211025012495 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1211025012496 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1211025012497 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1211025012498 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1211025012499 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1211025012500 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1211025012501 Predicted membrane protein [Function unknown]; Region: COG5393 1211025012502 YqjK-like protein; Region: YqjK; pfam13997 1211025012503 Predicted membrane protein [Function unknown]; Region: COG2259 1211025012504 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1211025012505 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1211025012506 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1211025012507 putative dimer interface [polypeptide binding]; other site 1211025012508 N-terminal domain interface [polypeptide binding]; other site 1211025012509 putative substrate binding pocket (H-site) [chemical binding]; other site 1211025012510 Predicted membrane protein [Function unknown]; Region: COG3152 1211025012511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025012512 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1211025012513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025012514 dimerization interface [polypeptide binding]; other site 1211025012515 Pirin-related protein [General function prediction only]; Region: COG1741 1211025012516 Pirin; Region: Pirin; pfam02678 1211025012517 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1211025012518 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1211025012519 serine transporter; Region: stp; TIGR00814 1211025012520 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1211025012521 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1211025012522 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1211025012523 dimer interface [polypeptide binding]; other site 1211025012524 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1211025012525 Pyruvate formate lyase 1; Region: PFL1; cd01678 1211025012526 coenzyme A binding site [chemical binding]; other site 1211025012527 active site 1211025012528 catalytic residues [active] 1211025012529 glycine loop; other site 1211025012530 propionate/acetate kinase; Provisional; Region: PRK12379 1211025012531 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1211025012532 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1211025012533 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1211025012534 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1211025012535 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1211025012536 tetramer interface [polypeptide binding]; other site 1211025012537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025012538 catalytic residue [active] 1211025012539 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1211025012540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025012541 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1211025012542 putative substrate binding pocket [chemical binding]; other site 1211025012543 putative dimerization interface [polypeptide binding]; other site 1211025012544 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1211025012545 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1211025012546 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1211025012547 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1211025012548 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1211025012549 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1211025012550 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1211025012551 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1211025012552 intersubunit interface [polypeptide binding]; other site 1211025012553 active site 1211025012554 zinc binding site [ion binding]; other site 1211025012555 Na+ binding site [ion binding]; other site 1211025012556 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1211025012557 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1211025012558 active site 1211025012559 phosphorylation site [posttranslational modification] 1211025012560 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1211025012561 active site 1211025012562 P-loop; other site 1211025012563 phosphorylation site [posttranslational modification] 1211025012564 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1211025012565 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1211025012566 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1211025012567 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1211025012568 putative NAD(P) binding site [chemical binding]; other site 1211025012569 catalytic Zn binding site [ion binding]; other site 1211025012570 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1211025012571 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1211025012572 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1211025012573 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1211025012574 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1211025012575 putative SAM binding site [chemical binding]; other site 1211025012576 putative homodimer interface [polypeptide binding]; other site 1211025012577 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1211025012578 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1211025012579 putative ligand binding site [chemical binding]; other site 1211025012580 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1211025012581 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1211025012582 dimer interface [polypeptide binding]; other site 1211025012583 active site 1211025012584 outer membrane lipoprotein; Provisional; Region: PRK11023 1211025012585 BON domain; Region: BON; pfam04972 1211025012586 BON domain; Region: BON; pfam04972 1211025012587 Predicted permease; Region: DUF318; pfam03773 1211025012588 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1211025012589 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1211025012590 NAD binding site [chemical binding]; other site 1211025012591 active site 1211025012592 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1211025012593 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1211025012594 proposed catalytic triad [active] 1211025012595 conserved cys residue [active] 1211025012596 hypothetical protein; Provisional; Region: PRK03467 1211025012597 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1211025012598 GIY-YIG motif/motif A; other site 1211025012599 putative active site [active] 1211025012600 putative metal binding site [ion binding]; other site 1211025012601 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1211025012602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025012603 Coenzyme A binding pocket [chemical binding]; other site 1211025012604 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1211025012605 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1211025012606 Peptidase family U32; Region: Peptidase_U32; pfam01136 1211025012607 putative protease; Provisional; Region: PRK15447 1211025012608 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1211025012609 hypothetical protein; Provisional; Region: PRK10508 1211025012610 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1211025012611 tryptophan permease; Provisional; Region: PRK10483 1211025012612 aromatic amino acid transport protein; Region: araaP; TIGR00837 1211025012613 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1211025012614 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1211025012615 ATP binding site [chemical binding]; other site 1211025012616 Mg++ binding site [ion binding]; other site 1211025012617 motif III; other site 1211025012618 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025012619 nucleotide binding region [chemical binding]; other site 1211025012620 ATP-binding site [chemical binding]; other site 1211025012621 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1211025012622 putative RNA binding site [nucleotide binding]; other site 1211025012623 lipoprotein NlpI; Provisional; Region: PRK11189 1211025012624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1211025012625 binding surface 1211025012626 TPR motif; other site 1211025012627 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1211025012628 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1211025012629 RNase E interface [polypeptide binding]; other site 1211025012630 trimer interface [polypeptide binding]; other site 1211025012631 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1211025012632 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1211025012633 RNase E interface [polypeptide binding]; other site 1211025012634 trimer interface [polypeptide binding]; other site 1211025012635 active site 1211025012636 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1211025012637 putative nucleic acid binding region [nucleotide binding]; other site 1211025012638 G-X-X-G motif; other site 1211025012639 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1211025012640 RNA binding site [nucleotide binding]; other site 1211025012641 domain interface; other site 1211025012642 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1211025012643 16S/18S rRNA binding site [nucleotide binding]; other site 1211025012644 S13e-L30e interaction site [polypeptide binding]; other site 1211025012645 25S rRNA binding site [nucleotide binding]; other site 1211025012646 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1211025012647 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1211025012648 RNA binding site [nucleotide binding]; other site 1211025012649 active site 1211025012650 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1211025012651 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1211025012652 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1211025012653 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1211025012654 translation initiation factor IF-2; Region: IF-2; TIGR00487 1211025012655 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1211025012656 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1211025012657 G1 box; other site 1211025012658 putative GEF interaction site [polypeptide binding]; other site 1211025012659 GTP/Mg2+ binding site [chemical binding]; other site 1211025012660 Switch I region; other site 1211025012661 G2 box; other site 1211025012662 G3 box; other site 1211025012663 Switch II region; other site 1211025012664 G4 box; other site 1211025012665 G5 box; other site 1211025012666 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1211025012667 Translation-initiation factor 2; Region: IF-2; pfam11987 1211025012668 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1211025012669 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1211025012670 NusA N-terminal domain; Region: NusA_N; pfam08529 1211025012671 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1211025012672 RNA binding site [nucleotide binding]; other site 1211025012673 homodimer interface [polypeptide binding]; other site 1211025012674 NusA-like KH domain; Region: KH_5; pfam13184 1211025012675 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1211025012676 G-X-X-G motif; other site 1211025012677 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1211025012678 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1211025012679 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1211025012680 Sm and related proteins; Region: Sm_like; cl00259 1211025012681 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1211025012682 putative oligomer interface [polypeptide binding]; other site 1211025012683 putative RNA binding site [nucleotide binding]; other site 1211025012684 argininosuccinate synthase; Validated; Region: PRK05370 1211025012685 argininosuccinate synthase; Provisional; Region: PRK13820 1211025012686 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1211025012687 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1211025012688 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1211025012689 active site 1211025012690 substrate binding site [chemical binding]; other site 1211025012691 metal binding site [ion binding]; metal-binding site 1211025012692 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1211025012693 dihydropteroate synthase; Region: DHPS; TIGR01496 1211025012694 substrate binding pocket [chemical binding]; other site 1211025012695 dimer interface [polypeptide binding]; other site 1211025012696 inhibitor binding site; inhibition site 1211025012697 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1211025012698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025012699 Walker A motif; other site 1211025012700 ATP binding site [chemical binding]; other site 1211025012701 Walker B motif; other site 1211025012702 arginine finger; other site 1211025012703 Peptidase family M41; Region: Peptidase_M41; pfam01434 1211025012704 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1211025012705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025012706 S-adenosylmethionine binding site [chemical binding]; other site 1211025012707 RNA-binding protein YhbY; Provisional; Region: PRK10343 1211025012708 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1211025012709 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1211025012710 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1211025012711 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1211025012712 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1211025012713 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1211025012714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025012715 active site 1211025012716 phosphorylation site [posttranslational modification] 1211025012717 intermolecular recognition site; other site 1211025012718 dimerization interface [polypeptide binding]; other site 1211025012719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025012720 DNA binding site [nucleotide binding] 1211025012721 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1211025012722 HAMP domain; Region: HAMP; pfam00672 1211025012723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025012724 dimer interface [polypeptide binding]; other site 1211025012725 phosphorylation site [posttranslational modification] 1211025012726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025012727 ATP binding site [chemical binding]; other site 1211025012728 Mg2+ binding site [ion binding]; other site 1211025012729 G-X-G motif; other site 1211025012730 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1211025012731 GTP1/OBG; Region: GTP1_OBG; pfam01018 1211025012732 Obg GTPase; Region: Obg; cd01898 1211025012733 G1 box; other site 1211025012734 GTP/Mg2+ binding site [chemical binding]; other site 1211025012735 Switch I region; other site 1211025012736 G2 box; other site 1211025012737 G3 box; other site 1211025012738 Switch II region; other site 1211025012739 G4 box; other site 1211025012740 G5 box; other site 1211025012741 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1211025012742 EamA-like transporter family; Region: EamA; pfam00892 1211025012743 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1211025012744 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1211025012745 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1211025012746 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1211025012747 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1211025012748 substrate binding pocket [chemical binding]; other site 1211025012749 chain length determination region; other site 1211025012750 substrate-Mg2+ binding site; other site 1211025012751 catalytic residues [active] 1211025012752 aspartate-rich region 1; other site 1211025012753 active site lid residues [active] 1211025012754 aspartate-rich region 2; other site 1211025012755 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1211025012756 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1211025012757 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1211025012758 hinge; other site 1211025012759 active site 1211025012760 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1211025012761 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1211025012762 anti sigma factor interaction site; other site 1211025012763 regulatory phosphorylation site [posttranslational modification]; other site 1211025012764 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1211025012765 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1211025012766 mce related protein; Region: MCE; pfam02470 1211025012767 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1211025012768 conserved hypothetical integral membrane protein; Region: TIGR00056 1211025012769 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1211025012770 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1211025012771 Walker A/P-loop; other site 1211025012772 ATP binding site [chemical binding]; other site 1211025012773 Q-loop/lid; other site 1211025012774 ABC transporter signature motif; other site 1211025012775 Walker B; other site 1211025012776 D-loop; other site 1211025012777 H-loop/switch region; other site 1211025012778 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1211025012779 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1211025012780 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1211025012781 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1211025012782 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1211025012783 putative active site [active] 1211025012784 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1211025012785 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1211025012786 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1211025012787 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1211025012788 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1211025012789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 1211025012790 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1211025012791 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1211025012792 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1211025012793 Walker A/P-loop; other site 1211025012794 ATP binding site [chemical binding]; other site 1211025012795 Q-loop/lid; other site 1211025012796 ABC transporter signature motif; other site 1211025012797 Walker B; other site 1211025012798 D-loop; other site 1211025012799 H-loop/switch region; other site 1211025012800 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1211025012801 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1211025012802 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1211025012803 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1211025012804 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1211025012805 30S subunit binding site; other site 1211025012806 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1211025012807 active site 1211025012808 phosphorylation site [posttranslational modification] 1211025012809 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1211025012810 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1211025012811 dimerization domain swap beta strand [polypeptide binding]; other site 1211025012812 regulatory protein interface [polypeptide binding]; other site 1211025012813 active site 1211025012814 regulatory phosphorylation site [posttranslational modification]; other site 1211025012815 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1211025012816 Transglycosylase; Region: Transgly; cl17702 1211025012817 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1211025012818 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1211025012819 conserved cys residue [active] 1211025012820 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1211025012821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1211025012822 putative active site [active] 1211025012823 heme pocket [chemical binding]; other site 1211025012824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025012825 dimer interface [polypeptide binding]; other site 1211025012826 phosphorylation site [posttranslational modification] 1211025012827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025012828 ATP binding site [chemical binding]; other site 1211025012829 Mg2+ binding site [ion binding]; other site 1211025012830 G-X-G motif; other site 1211025012831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025012832 active site 1211025012833 phosphorylation site [posttranslational modification] 1211025012834 intermolecular recognition site; other site 1211025012835 dimerization interface [polypeptide binding]; other site 1211025012836 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1211025012837 putative binding surface; other site 1211025012838 active site 1211025012839 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1211025012840 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1211025012841 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1211025012842 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1211025012843 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1211025012844 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1211025012845 interface (dimer of trimers) [polypeptide binding]; other site 1211025012846 Substrate-binding/catalytic site; other site 1211025012847 Zn-binding sites [ion binding]; other site 1211025012848 DNA polymerase III subunit chi; Validated; Region: PRK05728 1211025012849 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1211025012850 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1211025012851 HIGH motif; other site 1211025012852 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1211025012853 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1211025012854 active site 1211025012855 KMSKS motif; other site 1211025012856 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1211025012857 tRNA binding surface [nucleotide binding]; other site 1211025012858 anticodon binding site; other site 1211025012859 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1211025012860 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1211025012861 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1211025012862 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1211025012863 putative NAD(P) binding site [chemical binding]; other site 1211025012864 putative substrate binding site [chemical binding]; other site 1211025012865 catalytic Zn binding site [ion binding]; other site 1211025012866 structural Zn binding site [ion binding]; other site 1211025012867 dimer interface [polypeptide binding]; other site 1211025012868 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 1211025012869 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1211025012870 DAK2 domain; Region: Dak2; pfam02734 1211025012871 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1211025012872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1211025012873 Walker A motif; other site 1211025012874 ATP binding site [chemical binding]; other site 1211025012875 radical SAM protein, TIGR01212 family; Region: TIGR01212 1211025012876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025012877 FeS/SAM binding site; other site 1211025012878 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1211025012879 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1211025012880 active site 1211025012881 dimer interface [polypeptide binding]; other site 1211025012882 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1211025012883 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1211025012884 active site 1211025012885 FMN binding site [chemical binding]; other site 1211025012886 substrate binding site [chemical binding]; other site 1211025012887 3Fe-4S cluster binding site [ion binding]; other site 1211025012888 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1211025012889 domain interface; other site 1211025012890 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1211025012891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1211025012892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025012893 hypothetical protein; Provisional; Region: PRK15301 1211025012894 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1211025012895 PapC N-terminal domain; Region: PapC_N; pfam13954 1211025012896 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1211025012897 PapC C-terminal domain; Region: PapC_C; pfam13953 1211025012898 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1211025012899 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1211025012900 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1211025012901 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1211025012902 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1211025012903 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1211025012904 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1211025012905 C-terminal domain interface [polypeptide binding]; other site 1211025012906 putative GSH binding site (G-site) [chemical binding]; other site 1211025012907 dimer interface [polypeptide binding]; other site 1211025012908 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1211025012909 dimer interface [polypeptide binding]; other site 1211025012910 N-terminal domain interface [polypeptide binding]; other site 1211025012911 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1211025012912 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1211025012913 23S rRNA interface [nucleotide binding]; other site 1211025012914 L3 interface [polypeptide binding]; other site 1211025012915 Predicted ATPase [General function prediction only]; Region: COG1485 1211025012916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1211025012917 hypothetical protein; Provisional; Region: PRK11677 1211025012918 serine endoprotease; Provisional; Region: PRK10139 1211025012919 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1211025012920 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1211025012921 protein binding site [polypeptide binding]; other site 1211025012922 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1211025012923 serine endoprotease; Provisional; Region: PRK10898 1211025012924 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1211025012925 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1211025012926 malate dehydrogenase; Provisional; Region: PRK05086 1211025012927 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1211025012928 NAD binding site [chemical binding]; other site 1211025012929 dimerization interface [polypeptide binding]; other site 1211025012930 Substrate binding site [chemical binding]; other site 1211025012931 arginine repressor; Provisional; Region: PRK05066 1211025012932 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1211025012933 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1211025012934 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1211025012935 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1211025012936 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1211025012937 RNAase interaction site [polypeptide binding]; other site 1211025012938 succinic semialdehyde dehydrogenase; Region: PLN02278 1211025012939 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1211025012940 tetramerization interface [polypeptide binding]; other site 1211025012941 NAD(P) binding site [chemical binding]; other site 1211025012942 catalytic residues [active] 1211025012943 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1211025012944 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1211025012945 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1211025012946 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025012947 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025012948 efflux system membrane protein; Provisional; Region: PRK11594 1211025012949 transcriptional regulator; Provisional; Region: PRK10632 1211025012950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025012951 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1211025012952 putative effector binding pocket; other site 1211025012953 dimerization interface [polypeptide binding]; other site 1211025012954 protease TldD; Provisional; Region: tldD; PRK10735 1211025012955 hypothetical protein; Provisional; Region: PRK10899 1211025012956 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1211025012957 ribonuclease G; Provisional; Region: PRK11712 1211025012958 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1211025012959 homodimer interface [polypeptide binding]; other site 1211025012960 oligonucleotide binding site [chemical binding]; other site 1211025012961 Maf-like protein; Region: Maf; pfam02545 1211025012962 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1211025012963 active site 1211025012964 dimer interface [polypeptide binding]; other site 1211025012965 rod shape-determining protein MreD; Provisional; Region: PRK11060 1211025012966 rod shape-determining protein MreC; Region: mreC; TIGR00219 1211025012967 rod shape-determining protein MreC; Region: MreC; pfam04085 1211025012968 rod shape-determining protein MreB; Provisional; Region: PRK13927 1211025012969 MreB and similar proteins; Region: MreB_like; cd10225 1211025012970 nucleotide binding site [chemical binding]; other site 1211025012971 Mg binding site [ion binding]; other site 1211025012972 putative protofilament interaction site [polypeptide binding]; other site 1211025012973 RodZ interaction site [polypeptide binding]; other site 1211025012974 regulatory protein CsrD; Provisional; Region: PRK11059 1211025012975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025012976 metal binding site [ion binding]; metal-binding site 1211025012977 active site 1211025012978 I-site; other site 1211025012979 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025012980 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1211025012981 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1211025012982 NADP binding site [chemical binding]; other site 1211025012983 dimer interface [polypeptide binding]; other site 1211025012984 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1211025012985 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1211025012986 Moco binding site; other site 1211025012987 metal coordination site [ion binding]; other site 1211025012988 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1211025012989 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1211025012990 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1211025012991 trimer interface [polypeptide binding]; other site 1211025012992 active site 1211025012993 dimer interface [polypeptide binding]; other site 1211025012994 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1211025012995 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1211025012996 carboxyltransferase (CT) interaction site; other site 1211025012997 biotinylation site [posttranslational modification]; other site 1211025012998 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1211025012999 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1211025013000 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1211025013001 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1211025013002 Peptidase M60-like family; Region: M60-like; pfam13402 1211025013003 Peptidase M60-like family; Region: M60-like; pfam13402 1211025013004 hypothetical protein; Provisional; Region: PRK10633 1211025013005 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1211025013006 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1211025013007 Na binding site [ion binding]; other site 1211025013008 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1211025013009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1211025013010 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1211025013011 active site 1211025013012 zinc binding site [ion binding]; other site 1211025013013 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1211025013014 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1211025013015 FMN binding site [chemical binding]; other site 1211025013016 active site 1211025013017 catalytic residues [active] 1211025013018 substrate binding site [chemical binding]; other site 1211025013019 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1211025013020 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1211025013021 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1211025013022 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1211025013023 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1211025013024 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1211025013025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1211025013026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025013027 metal binding site [ion binding]; metal-binding site 1211025013028 active site 1211025013029 I-site; other site 1211025013030 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025013031 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1211025013032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025013033 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1211025013034 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1211025013035 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1211025013036 HlyD family secretion protein; Region: HlyD_3; pfam13437 1211025013037 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1211025013038 Protein export membrane protein; Region: SecD_SecF; cl14618 1211025013039 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025013040 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1211025013041 substrate binding pocket [chemical binding]; other site 1211025013042 membrane-bound complex binding site; other site 1211025013043 hinge residues; other site 1211025013044 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1211025013045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025013046 conserved gate region; other site 1211025013047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025013048 dimer interface [polypeptide binding]; other site 1211025013049 ABC-ATPase subunit interface; other site 1211025013050 putative PBP binding loops; other site 1211025013051 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1211025013052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025013053 dimer interface [polypeptide binding]; other site 1211025013054 conserved gate region; other site 1211025013055 putative PBP binding loops; other site 1211025013056 ABC-ATPase subunit interface; other site 1211025013057 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1211025013058 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1211025013059 Walker A/P-loop; other site 1211025013060 ATP binding site [chemical binding]; other site 1211025013061 Q-loop/lid; other site 1211025013062 ABC transporter signature motif; other site 1211025013063 Walker B; other site 1211025013064 D-loop; other site 1211025013065 H-loop/switch region; other site 1211025013066 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1211025013067 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1211025013068 trimer interface [polypeptide binding]; other site 1211025013069 putative metal binding site [ion binding]; other site 1211025013070 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1211025013071 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1211025013072 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1211025013073 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1211025013074 shikimate binding site; other site 1211025013075 NAD(P) binding site [chemical binding]; other site 1211025013076 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1211025013077 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1211025013078 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1211025013079 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1211025013080 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1211025013081 hypothetical protein; Validated; Region: PRK03430 1211025013082 hypothetical protein; Provisional; Region: PRK10736 1211025013083 DNA protecting protein DprA; Region: dprA; TIGR00732 1211025013084 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1211025013085 active site 1211025013086 catalytic residues [active] 1211025013087 metal binding site [ion binding]; metal-binding site 1211025013088 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1211025013089 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1211025013090 putative active site [active] 1211025013091 substrate binding site [chemical binding]; other site 1211025013092 putative cosubstrate binding site; other site 1211025013093 catalytic site [active] 1211025013094 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1211025013095 substrate binding site [chemical binding]; other site 1211025013096 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1211025013097 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1211025013098 putative RNA binding site [nucleotide binding]; other site 1211025013099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025013100 S-adenosylmethionine binding site [chemical binding]; other site 1211025013101 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1211025013102 TrkA-N domain; Region: TrkA_N; pfam02254 1211025013103 TrkA-C domain; Region: TrkA_C; pfam02080 1211025013104 TrkA-N domain; Region: TrkA_N; pfam02254 1211025013105 TrkA-C domain; Region: TrkA_C; pfam02080 1211025013106 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1211025013107 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1211025013108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1211025013109 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1211025013110 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1211025013111 DNA binding residues [nucleotide binding] 1211025013112 dimer interface [polypeptide binding]; other site 1211025013113 metal binding site [ion binding]; metal-binding site 1211025013114 hypothetical protein; Provisional; Region: PRK10203 1211025013115 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1211025013116 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1211025013117 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1211025013118 alphaNTD homodimer interface [polypeptide binding]; other site 1211025013119 alphaNTD - beta interaction site [polypeptide binding]; other site 1211025013120 alphaNTD - beta' interaction site [polypeptide binding]; other site 1211025013121 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1211025013122 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1211025013123 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1211025013124 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1211025013125 RNA binding surface [nucleotide binding]; other site 1211025013126 30S ribosomal protein S11; Validated; Region: PRK05309 1211025013127 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1211025013128 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1211025013129 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1211025013130 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1211025013131 SecY translocase; Region: SecY; pfam00344 1211025013132 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1211025013133 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1211025013134 23S rRNA binding site [nucleotide binding]; other site 1211025013135 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1211025013136 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1211025013137 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1211025013138 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1211025013139 23S rRNA interface [nucleotide binding]; other site 1211025013140 5S rRNA interface [nucleotide binding]; other site 1211025013141 L27 interface [polypeptide binding]; other site 1211025013142 L5 interface [polypeptide binding]; other site 1211025013143 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1211025013144 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1211025013145 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1211025013146 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1211025013147 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1211025013148 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1211025013149 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1211025013150 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1211025013151 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1211025013152 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1211025013153 RNA binding site [nucleotide binding]; other site 1211025013154 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1211025013155 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1211025013156 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1211025013157 23S rRNA interface [nucleotide binding]; other site 1211025013158 putative translocon interaction site; other site 1211025013159 signal recognition particle (SRP54) interaction site; other site 1211025013160 L23 interface [polypeptide binding]; other site 1211025013161 trigger factor interaction site; other site 1211025013162 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1211025013163 23S rRNA interface [nucleotide binding]; other site 1211025013164 5S rRNA interface [nucleotide binding]; other site 1211025013165 putative antibiotic binding site [chemical binding]; other site 1211025013166 L25 interface [polypeptide binding]; other site 1211025013167 L27 interface [polypeptide binding]; other site 1211025013168 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1211025013169 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1211025013170 G-X-X-G motif; other site 1211025013171 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1211025013172 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1211025013173 protein-rRNA interface [nucleotide binding]; other site 1211025013174 putative translocon binding site; other site 1211025013175 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1211025013176 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1211025013177 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1211025013178 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1211025013179 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1211025013180 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1211025013181 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1211025013182 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1211025013183 protein secretion protein GspB; Provisional; Region: PRK09697 1211025013184 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1211025013185 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 1211025013186 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1211025013187 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1211025013188 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1211025013189 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1211025013190 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1211025013191 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1211025013192 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1211025013193 Walker A motif; other site 1211025013194 ATP binding site [chemical binding]; other site 1211025013195 Walker B motif; other site 1211025013196 type II secretion system protein F; Region: GspF; TIGR02120 1211025013197 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1211025013198 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1211025013199 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1211025013200 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1211025013201 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1211025013202 Type II transport protein GspH; Region: GspH; pfam12019 1211025013203 type II secretion system protein I; Region: gspI; TIGR01707 1211025013204 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1211025013205 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 1211025013206 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1211025013207 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1211025013208 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1211025013209 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 1211025013210 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1211025013211 GspL periplasmic domain; Region: GspL_C; cl14909 1211025013212 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1211025013213 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1211025013214 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1211025013215 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1211025013216 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1211025013217 heme binding site [chemical binding]; other site 1211025013218 ferroxidase pore; other site 1211025013219 ferroxidase diiron center [ion binding]; other site 1211025013220 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1211025013221 elongation factor Tu; Reviewed; Region: PRK00049 1211025013222 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1211025013223 G1 box; other site 1211025013224 GEF interaction site [polypeptide binding]; other site 1211025013225 GTP/Mg2+ binding site [chemical binding]; other site 1211025013226 Switch I region; other site 1211025013227 G2 box; other site 1211025013228 G3 box; other site 1211025013229 Switch II region; other site 1211025013230 G4 box; other site 1211025013231 G5 box; other site 1211025013232 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1211025013233 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1211025013234 Antibiotic Binding Site [chemical binding]; other site 1211025013235 elongation factor G; Reviewed; Region: PRK00007 1211025013236 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1211025013237 G1 box; other site 1211025013238 putative GEF interaction site [polypeptide binding]; other site 1211025013239 GTP/Mg2+ binding site [chemical binding]; other site 1211025013240 Switch I region; other site 1211025013241 G2 box; other site 1211025013242 G3 box; other site 1211025013243 Switch II region; other site 1211025013244 G4 box; other site 1211025013245 G5 box; other site 1211025013246 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1211025013247 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1211025013248 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1211025013249 30S ribosomal protein S7; Validated; Region: PRK05302 1211025013250 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1211025013251 S17 interaction site [polypeptide binding]; other site 1211025013252 S8 interaction site; other site 1211025013253 16S rRNA interaction site [nucleotide binding]; other site 1211025013254 streptomycin interaction site [chemical binding]; other site 1211025013255 23S rRNA interaction site [nucleotide binding]; other site 1211025013256 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1211025013257 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1211025013258 sulfur relay protein TusC; Validated; Region: PRK00211 1211025013259 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1211025013260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1211025013261 YheO-like PAS domain; Region: PAS_6; pfam08348 1211025013262 HTH domain; Region: HTH_22; pfam13309 1211025013263 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1211025013264 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1211025013265 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1211025013266 phi X174 lysis protein; Provisional; Region: PRK02793 1211025013267 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1211025013268 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1211025013269 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1211025013270 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1211025013271 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1211025013272 TrkA-N domain; Region: TrkA_N; pfam02254 1211025013273 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1211025013274 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1211025013275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1211025013276 Walker A/P-loop; other site 1211025013277 ATP binding site [chemical binding]; other site 1211025013278 Q-loop/lid; other site 1211025013279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025013280 ABC transporter; Region: ABC_tran_2; pfam12848 1211025013281 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1211025013282 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1211025013283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025013284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025013285 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1211025013286 putative dimerization interface [polypeptide binding]; other site 1211025013287 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1211025013288 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1211025013289 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1211025013290 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1211025013291 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1211025013292 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 1211025013293 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1211025013294 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 1211025013295 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1211025013296 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1211025013297 Coenzyme A transferase; Region: CoA_trans; cl17247 1211025013298 putative hydrolase; Provisional; Region: PRK10985 1211025013299 hypothetical protein; Provisional; Region: PRK04966 1211025013300 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1211025013301 active site 1211025013302 hypothetical protein; Provisional; Region: PRK10738 1211025013303 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1211025013304 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1211025013305 ligand binding site [chemical binding]; other site 1211025013306 flexible hinge region; other site 1211025013307 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1211025013308 putative switch regulator; other site 1211025013309 non-specific DNA interactions [nucleotide binding]; other site 1211025013310 DNA binding site [nucleotide binding] 1211025013311 sequence specific DNA binding site [nucleotide binding]; other site 1211025013312 putative cAMP binding site [chemical binding]; other site 1211025013313 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1211025013314 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1211025013315 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1211025013316 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1211025013317 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1211025013318 inhibitor-cofactor binding pocket; inhibition site 1211025013319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025013320 catalytic residue [active] 1211025013321 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1211025013322 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1211025013323 glutamine binding [chemical binding]; other site 1211025013324 catalytic triad [active] 1211025013325 hypothetical protein; Provisional; Region: PRK10204 1211025013326 Fic/DOC family; Region: Fic; cl00960 1211025013327 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1211025013328 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1211025013329 substrate binding site [chemical binding]; other site 1211025013330 putative transporter; Provisional; Region: PRK03699 1211025013331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025013332 putative substrate translocation pore; other site 1211025013333 cytosine deaminase; Provisional; Region: PRK09230 1211025013334 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1211025013335 active site 1211025013336 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1211025013337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025013338 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1211025013339 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1211025013340 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1211025013341 siroheme synthase; Provisional; Region: cysG; PRK10637 1211025013342 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1211025013343 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1211025013344 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1211025013345 active site 1211025013346 SAM binding site [chemical binding]; other site 1211025013347 homodimer interface [polypeptide binding]; other site 1211025013348 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1211025013349 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1211025013350 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1211025013351 active site 1211025013352 HIGH motif; other site 1211025013353 dimer interface [polypeptide binding]; other site 1211025013354 KMSKS motif; other site 1211025013355 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1211025013356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025013357 motif II; other site 1211025013358 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1211025013359 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1211025013360 substrate binding site [chemical binding]; other site 1211025013361 hexamer interface [polypeptide binding]; other site 1211025013362 metal binding site [ion binding]; metal-binding site 1211025013363 DNA adenine methylase; Provisional; Region: PRK10904 1211025013364 hypothetical protein; Reviewed; Region: PRK11901 1211025013365 cell division protein DamX; Validated; Region: PRK10905 1211025013366 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1211025013367 active site 1211025013368 dimer interface [polypeptide binding]; other site 1211025013369 metal binding site [ion binding]; metal-binding site 1211025013370 shikimate kinase; Reviewed; Region: aroK; PRK00131 1211025013371 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1211025013372 ADP binding site [chemical binding]; other site 1211025013373 magnesium binding site [ion binding]; other site 1211025013374 putative shikimate binding site; other site 1211025013375 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1211025013376 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1211025013377 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1211025013378 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1211025013379 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1211025013380 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1211025013381 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1211025013382 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1211025013383 Transglycosylase; Region: Transgly; pfam00912 1211025013384 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1211025013385 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1211025013386 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1211025013387 ADP-ribose binding site [chemical binding]; other site 1211025013388 dimer interface [polypeptide binding]; other site 1211025013389 active site 1211025013390 nudix motif; other site 1211025013391 metal binding site [ion binding]; metal-binding site 1211025013392 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1211025013393 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1211025013394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025013395 motif II; other site 1211025013396 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1211025013397 RNA binding surface [nucleotide binding]; other site 1211025013398 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1211025013399 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1211025013400 dimerization interface [polypeptide binding]; other site 1211025013401 domain crossover interface; other site 1211025013402 redox-dependent activation switch; other site 1211025013403 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1211025013404 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1211025013405 active site 1211025013406 substrate-binding site [chemical binding]; other site 1211025013407 metal-binding site [ion binding] 1211025013408 ATP binding site [chemical binding]; other site 1211025013409 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1211025013410 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1211025013411 dimerization interface [polypeptide binding]; other site 1211025013412 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025013413 dimer interface [polypeptide binding]; other site 1211025013414 phosphorylation site [posttranslational modification] 1211025013415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025013416 ATP binding site [chemical binding]; other site 1211025013417 G-X-G motif; other site 1211025013418 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1211025013419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025013420 active site 1211025013421 phosphorylation site [posttranslational modification] 1211025013422 intermolecular recognition site; other site 1211025013423 dimerization interface [polypeptide binding]; other site 1211025013424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025013425 DNA binding site [nucleotide binding] 1211025013426 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1211025013427 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1211025013428 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1211025013429 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1211025013430 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1211025013431 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1211025013432 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1211025013433 RNA binding site [nucleotide binding]; other site 1211025013434 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1211025013435 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1211025013436 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1211025013437 G1 box; other site 1211025013438 GTP/Mg2+ binding site [chemical binding]; other site 1211025013439 Switch I region; other site 1211025013440 G2 box; other site 1211025013441 G3 box; other site 1211025013442 Switch II region; other site 1211025013443 G4 box; other site 1211025013444 G5 box; other site 1211025013445 Nucleoside recognition; Region: Gate; pfam07670 1211025013446 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1211025013447 Nucleoside recognition; Region: Gate; pfam07670 1211025013448 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1211025013449 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1211025013450 carboxylesterase BioH; Provisional; Region: PRK10349 1211025013451 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1211025013452 DNA utilization protein GntX; Provisional; Region: PRK11595 1211025013453 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1211025013454 active site 1211025013455 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1211025013456 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1211025013457 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1211025013458 high-affinity gluconate transporter; Provisional; Region: PRK14984 1211025013459 gluconate transporter; Region: gntP; TIGR00791 1211025013460 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1211025013461 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1211025013462 maltodextrin phosphorylase; Provisional; Region: PRK14985 1211025013463 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1211025013464 active site pocket [active] 1211025013465 transcriptional regulator MalT; Provisional; Region: PRK04841 1211025013466 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025013467 DNA binding residues [nucleotide binding] 1211025013468 dimerization interface [polypeptide binding]; other site 1211025013469 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1211025013470 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1211025013471 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1211025013472 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1211025013473 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1211025013474 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1211025013475 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1211025013476 active site residue [active] 1211025013477 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1211025013478 glycogen phosphorylase; Provisional; Region: PRK14986 1211025013479 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1211025013480 homodimer interface [polypeptide binding]; other site 1211025013481 active site pocket [active] 1211025013482 glycogen synthase; Provisional; Region: glgA; PRK00654 1211025013483 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1211025013484 ADP-binding pocket [chemical binding]; other site 1211025013485 homodimer interface [polypeptide binding]; other site 1211025013486 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1211025013487 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1211025013488 ligand binding site; other site 1211025013489 oligomer interface; other site 1211025013490 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1211025013491 dimer interface [polypeptide binding]; other site 1211025013492 N-terminal domain interface [polypeptide binding]; other site 1211025013493 sulfate 1 binding site; other site 1211025013494 glycogen debranching enzyme; Provisional; Region: PRK03705 1211025013495 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1211025013496 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1211025013497 active site 1211025013498 catalytic site [active] 1211025013499 glycogen branching enzyme; Provisional; Region: PRK05402 1211025013500 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1211025013501 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1211025013502 active site 1211025013503 catalytic site [active] 1211025013504 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1211025013505 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1211025013506 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1211025013507 putative antibiotic transporter; Provisional; Region: PRK10739 1211025013508 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1211025013509 CPxP motif; other site 1211025013510 hypothetical protein; Provisional; Region: PRK11212 1211025013511 hypothetical protein; Provisional; Region: PRK11615 1211025013512 major facilitator superfamily transporter; Provisional; Region: PRK05122 1211025013513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025013514 putative substrate translocation pore; other site 1211025013515 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1211025013516 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1211025013517 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1211025013518 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1211025013519 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1211025013520 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1211025013521 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1211025013522 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1211025013523 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1211025013524 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1211025013525 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1211025013526 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1211025013527 active site 1211025013528 substrate binding site [chemical binding]; other site 1211025013529 cosubstrate binding site; other site 1211025013530 catalytic site [active] 1211025013531 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1211025013532 active site 1211025013533 hexamer interface [polypeptide binding]; other site 1211025013534 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1211025013535 NAD binding site [chemical binding]; other site 1211025013536 substrate binding site [chemical binding]; other site 1211025013537 active site 1211025013538 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1211025013539 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1211025013540 Ligand binding site; other site 1211025013541 Putative Catalytic site; other site 1211025013542 DXD motif; other site 1211025013543 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1211025013544 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1211025013545 inhibitor-cofactor binding pocket; inhibition site 1211025013546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025013547 catalytic residue [active] 1211025013548 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 1211025013549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025013550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025013551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025013552 dimerization interface [polypeptide binding]; other site 1211025013553 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1211025013554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1211025013555 NAD(P) binding site [chemical binding]; other site 1211025013556 active site 1211025013557 NlpC/P60 family; Region: NLPC_P60; pfam00877 1211025013558 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1211025013559 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1211025013560 Integral membrane protein TerC family; Region: TerC; cl10468 1211025013561 Predicted flavoproteins [General function prediction only]; Region: COG2081 1211025013562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1211025013563 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1211025013564 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1211025013565 universal stress protein UspB; Provisional; Region: PRK04960 1211025013566 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1211025013567 Ligand Binding Site [chemical binding]; other site 1211025013568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025013569 S-adenosylmethionine binding site [chemical binding]; other site 1211025013570 oligopeptidase A; Provisional; Region: PRK10911 1211025013571 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1211025013572 active site 1211025013573 Zn binding site [ion binding]; other site 1211025013574 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1211025013575 glutathione reductase; Validated; Region: PRK06116 1211025013576 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1211025013577 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025013578 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1211025013579 trehalase; Provisional; Region: treF; PRK13270 1211025013580 Trehalase; Region: Trehalase; pfam01204 1211025013581 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1211025013582 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1211025013583 Coenzyme A binding pocket [chemical binding]; other site 1211025013584 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1211025013585 catalytic residue [active] 1211025013586 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1211025013587 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1211025013588 DNA binding residues [nucleotide binding] 1211025013589 dimerization interface [polypeptide binding]; other site 1211025013590 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1211025013591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1211025013592 NAD(P) binding site [chemical binding]; other site 1211025013593 active site 1211025013594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1211025013595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025013596 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1211025013597 putative effector binding pocket; other site 1211025013598 putative dimerization interface [polypeptide binding]; other site 1211025013599 inner membrane protein YhjD; Region: TIGR00766 1211025013600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025013601 metabolite-proton symporter; Region: 2A0106; TIGR00883 1211025013602 putative substrate translocation pore; other site 1211025013603 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1211025013604 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1211025013605 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025013606 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1211025013607 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1211025013608 substrate binding site [chemical binding]; other site 1211025013609 ATP binding site [chemical binding]; other site 1211025013610 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1211025013611 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1211025013612 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1211025013613 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1211025013614 putative diguanylate cyclase; Provisional; Region: PRK13561 1211025013615 HAMP domain; Region: HAMP; pfam00672 1211025013616 dimerization interface [polypeptide binding]; other site 1211025013617 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1211025013618 metal binding site [ion binding]; metal-binding site 1211025013619 active site 1211025013620 I-site; other site 1211025013621 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1211025013622 potential frameshift: common BLAST hit: gi|296105261|ref|YP_003615407.1| cellulose synthase subunit BcsC 1211025013623 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1211025013624 cellulose synthase regulator protein; Provisional; Region: PRK11114 1211025013625 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1211025013626 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1211025013627 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1211025013628 DXD motif; other site 1211025013629 PilZ domain; Region: PilZ; pfam07238 1211025013630 cell division protein; Provisional; Region: PRK10037 1211025013631 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1211025013632 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1211025013633 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1211025013634 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1211025013635 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1211025013636 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1211025013637 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1211025013638 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1211025013639 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1211025013640 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1211025013641 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1211025013642 FAD binding domain; Region: FAD_binding_4; pfam01565 1211025013643 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1211025013644 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1211025013645 potassium transporter; Provisional; Region: PRK10750 1211025013646 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1211025013647 hypothetical protein; Provisional; Region: PRK11568 1211025013648 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1211025013649 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1211025013650 proline dipeptidase; Provisional; Region: PRK13607 1211025013651 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1211025013652 active site 1211025013653 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1211025013654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1211025013655 substrate binding site [chemical binding]; other site 1211025013656 oxyanion hole (OAH) forming residues; other site 1211025013657 trimer interface [polypeptide binding]; other site 1211025013658 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1211025013659 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1211025013660 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1211025013661 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1211025013662 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1211025013663 dimer interface [polypeptide binding]; other site 1211025013664 active site 1211025013665 FMN reductase; Validated; Region: fre; PRK08051 1211025013666 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1211025013667 FAD binding pocket [chemical binding]; other site 1211025013668 FAD binding motif [chemical binding]; other site 1211025013669 phosphate binding motif [ion binding]; other site 1211025013670 beta-alpha-beta structure motif; other site 1211025013671 NAD binding pocket [chemical binding]; other site 1211025013672 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1211025013673 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1211025013674 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1211025013675 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1211025013676 active site 1211025013677 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1211025013678 sec-independent translocase; Provisional; Region: PRK01770 1211025013679 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1211025013680 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1211025013681 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1211025013682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1211025013683 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1211025013684 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1211025013685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025013686 S-adenosylmethionine binding site [chemical binding]; other site 1211025013687 DNA recombination protein RmuC; Provisional; Region: PRK10361 1211025013688 RmuC family; Region: RmuC; pfam02646 1211025013689 uridine phosphorylase; Provisional; Region: PRK11178 1211025013690 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1211025013691 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1211025013692 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1211025013693 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1211025013694 active site 1211025013695 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1211025013696 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1211025013697 Ca binding site [ion binding]; other site 1211025013698 active site 1211025013699 catalytic site [active] 1211025013700 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1211025013701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025013702 dimer interface [polypeptide binding]; other site 1211025013703 conserved gate region; other site 1211025013704 putative PBP binding loops; other site 1211025013705 ABC-ATPase subunit interface; other site 1211025013706 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1211025013707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1211025013708 dimer interface [polypeptide binding]; other site 1211025013709 putative PBP binding loops; other site 1211025013710 ABC-ATPase subunit interface; other site 1211025013711 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1211025013712 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1211025013713 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025013714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025013715 DNA binding site [nucleotide binding] 1211025013716 domain linker motif; other site 1211025013717 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1211025013718 putative dimerization interface [polypeptide binding]; other site 1211025013719 putative ligand binding site [chemical binding]; other site 1211025013720 phosphomannomutase CpsG; Provisional; Region: PRK15414 1211025013721 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1211025013722 active site 1211025013723 substrate binding site [chemical binding]; other site 1211025013724 metal binding site [ion binding]; metal-binding site 1211025013725 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1211025013726 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1211025013727 Walker A/P-loop; other site 1211025013728 ATP binding site [chemical binding]; other site 1211025013729 Q-loop/lid; other site 1211025013730 ABC transporter signature motif; other site 1211025013731 Walker B; other site 1211025013732 D-loop; other site 1211025013733 H-loop/switch region; other site 1211025013734 TOBE domain; Region: TOBE_2; pfam08402 1211025013735 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1211025013736 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1211025013737 THF binding site; other site 1211025013738 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1211025013739 substrate binding site [chemical binding]; other site 1211025013740 THF binding site; other site 1211025013741 zinc-binding site [ion binding]; other site 1211025013742 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1211025013743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025013744 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1211025013745 putative dimerization interface [polypeptide binding]; other site 1211025013746 EamA-like transporter family; Region: EamA; pfam00892 1211025013747 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1211025013748 putative hydrolase; Provisional; Region: PRK10976 1211025013749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025013750 active site 1211025013751 motif I; other site 1211025013752 motif II; other site 1211025013753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025013754 lysophospholipase L2; Provisional; Region: PRK10749 1211025013755 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1211025013756 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1211025013757 threonine efflux system; Provisional; Region: PRK10229 1211025013758 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1211025013759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025013760 ATP binding site [chemical binding]; other site 1211025013761 putative Mg++ binding site [ion binding]; other site 1211025013762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025013763 nucleotide binding region [chemical binding]; other site 1211025013764 ATP-binding site [chemical binding]; other site 1211025013765 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1211025013766 HRDC domain; Region: HRDC; pfam00570 1211025013767 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1211025013768 dimerization interface [polypeptide binding]; other site 1211025013769 substrate binding site [chemical binding]; other site 1211025013770 active site 1211025013771 calcium binding site [ion binding]; other site 1211025013772 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1211025013773 CoenzymeA binding site [chemical binding]; other site 1211025013774 subunit interaction site [polypeptide binding]; other site 1211025013775 PHB binding site; other site 1211025013776 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1211025013777 EamA-like transporter family; Region: EamA; pfam00892 1211025013778 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1211025013779 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1211025013780 Cl binding site [ion binding]; other site 1211025013781 oligomer interface [polypeptide binding]; other site 1211025013782 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1211025013783 Part of AAA domain; Region: AAA_19; pfam13245 1211025013784 Family description; Region: UvrD_C_2; pfam13538 1211025013785 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1211025013786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025013787 motif II; other site 1211025013788 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1211025013789 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1211025013790 active site 1211025013791 DNA binding site [nucleotide binding] 1211025013792 Int/Topo IB signature motif; other site 1211025013793 hypothetical protein; Provisional; Region: PRK10963 1211025013794 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1211025013795 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1211025013796 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1211025013797 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1211025013798 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1211025013799 putative iron binding site [ion binding]; other site 1211025013800 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1211025013801 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1211025013802 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1211025013803 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1211025013804 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1211025013805 domain interfaces; other site 1211025013806 active site 1211025013807 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1211025013808 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1211025013809 active site 1211025013810 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1211025013811 HemX; Region: HemX; pfam04375 1211025013812 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1211025013813 HemY protein N-terminus; Region: HemY_N; pfam07219 1211025013814 putative transport protein YifK; Provisional; Region: PRK10746 1211025013815 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1211025013816 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1211025013817 putative common antigen polymerase; Provisional; Region: PRK02975 1211025013818 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1211025013819 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1211025013820 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1211025013821 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1211025013822 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1211025013823 inhibitor-cofactor binding pocket; inhibition site 1211025013824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025013825 catalytic residue [active] 1211025013826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025013827 Coenzyme A binding pocket [chemical binding]; other site 1211025013828 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1211025013829 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1211025013830 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1211025013831 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1211025013832 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1211025013833 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1211025013834 active site 1211025013835 homodimer interface [polypeptide binding]; other site 1211025013836 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1211025013837 Chain length determinant protein; Region: Wzz; pfam02706 1211025013838 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1211025013839 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1211025013840 Mg++ binding site [ion binding]; other site 1211025013841 putative catalytic motif [active] 1211025013842 substrate binding site [chemical binding]; other site 1211025013843 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1211025013844 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1211025013845 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1211025013846 RNA binding site [nucleotide binding]; other site 1211025013847 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1211025013848 multimer interface [polypeptide binding]; other site 1211025013849 Walker A motif; other site 1211025013850 ATP binding site [chemical binding]; other site 1211025013851 Walker B motif; other site 1211025013852 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1211025013853 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1211025013854 catalytic residues [active] 1211025013855 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1211025013856 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1211025013857 ATP binding site [chemical binding]; other site 1211025013858 Mg++ binding site [ion binding]; other site 1211025013859 motif III; other site 1211025013860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1211025013861 nucleotide binding region [chemical binding]; other site 1211025013862 ATP-binding site [chemical binding]; other site 1211025013863 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1211025013864 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1211025013865 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1211025013866 Part of AAA domain; Region: AAA_19; pfam13245 1211025013867 Family description; Region: UvrD_C_2; pfam13538 1211025013868 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1211025013869 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1211025013870 ketol-acid reductoisomerase; Validated; Region: PRK05225 1211025013871 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1211025013872 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1211025013873 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1211025013874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025013875 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1211025013876 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1211025013877 putative dimerization interface [polypeptide binding]; other site 1211025013878 threonine dehydratase; Reviewed; Region: PRK09224 1211025013879 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1211025013880 tetramer interface [polypeptide binding]; other site 1211025013881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025013882 catalytic residue [active] 1211025013883 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1211025013884 putative Ile/Val binding site [chemical binding]; other site 1211025013885 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1211025013886 putative Ile/Val binding site [chemical binding]; other site 1211025013887 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1211025013888 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1211025013889 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1211025013890 homodimer interface [polypeptide binding]; other site 1211025013891 substrate-cofactor binding pocket; other site 1211025013892 catalytic residue [active] 1211025013893 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1211025013894 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1211025013895 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1211025013896 PYR/PP interface [polypeptide binding]; other site 1211025013897 dimer interface [polypeptide binding]; other site 1211025013898 TPP binding site [chemical binding]; other site 1211025013899 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1211025013900 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1211025013901 TPP-binding site [chemical binding]; other site 1211025013902 dimer interface [polypeptide binding]; other site 1211025013903 putative ATP-dependent protease; Provisional; Region: PRK09862 1211025013904 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1211025013905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025013906 Walker A motif; other site 1211025013907 ATP binding site [chemical binding]; other site 1211025013908 Walker B motif; other site 1211025013909 arginine finger; other site 1211025013910 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1211025013911 hypothetical protein; Provisional; Region: PRK11027 1211025013912 transcriptional regulator HdfR; Provisional; Region: PRK03601 1211025013913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025013914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1211025013915 dimerization interface [polypeptide binding]; other site 1211025013916 glutamate racemase; Provisional; Region: PRK00865 1211025013917 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1211025013918 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1211025013919 N-terminal plug; other site 1211025013920 ligand-binding site [chemical binding]; other site 1211025013921 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1211025013922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1211025013923 S-adenosylmethionine binding site [chemical binding]; other site 1211025013924 hypothetical protein; Provisional; Region: PRK11056 1211025013925 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1211025013926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1211025013927 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1211025013928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1211025013929 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1211025013930 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1211025013931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1211025013932 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1211025013933 dimerization interface [polypeptide binding]; other site 1211025013934 argininosuccinate lyase; Provisional; Region: PRK04833 1211025013935 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1211025013936 active sites [active] 1211025013937 tetramer interface [polypeptide binding]; other site 1211025013938 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1211025013939 nucleotide binding site [chemical binding]; other site 1211025013940 N-acetyl-L-glutamate binding site [chemical binding]; other site 1211025013941 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1211025013942 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1211025013943 acetylornithine deacetylase; Provisional; Region: PRK05111 1211025013944 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1211025013945 metal binding site [ion binding]; metal-binding site 1211025013946 putative dimer interface [polypeptide binding]; other site 1211025013947 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1211025013948 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1211025013949 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1211025013950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025013951 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1211025013952 active site 1211025013953 intersubunit interactions; other site 1211025013954 catalytic residue [active] 1211025013955 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1211025013956 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1211025013957 dimer interface [polypeptide binding]; other site 1211025013958 active site 1211025013959 metal binding site [ion binding]; metal-binding site 1211025013960 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1211025013961 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1211025013962 heme binding site [chemical binding]; other site 1211025013963 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1211025013964 heme binding site [chemical binding]; other site 1211025013965 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1211025013966 FAD binding site [chemical binding]; other site 1211025013967 potential frameshift: common BLAST hit: gi|365972709|ref|YP_004954270.1| bifunctional aspartokinase/homoserine dehydrogenase 2 1211025013968 cystathionine gamma-synthase; Provisional; Region: PRK08045 1211025013969 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1211025013970 homodimer interface [polypeptide binding]; other site 1211025013971 substrate-cofactor binding pocket; other site 1211025013972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1211025013973 catalytic residue [active] 1211025013974 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1211025013975 dimerization interface [polypeptide binding]; other site 1211025013976 DNA binding site [nucleotide binding] 1211025013977 corepressor binding sites; other site 1211025013978 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1211025013979 primosome assembly protein PriA; Validated; Region: PRK05580 1211025013980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1211025013981 ATP binding site [chemical binding]; other site 1211025013982 putative Mg++ binding site [ion binding]; other site 1211025013983 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1211025013984 ATP-binding site [chemical binding]; other site 1211025013985 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025013986 DNA binding site [nucleotide binding] 1211025013987 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1211025013988 domain linker motif; other site 1211025013989 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1211025013990 dimerization interface [polypeptide binding]; other site 1211025013991 ligand binding site [chemical binding]; other site 1211025013992 essential cell division protein FtsN; Provisional; Region: PRK10927 1211025013993 cell division protein FtsN; Provisional; Region: PRK12757 1211025013994 Sporulation related domain; Region: SPOR; cl10051 1211025013995 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1211025013996 active site 1211025013997 HslU subunit interaction site [polypeptide binding]; other site 1211025013998 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1211025013999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025014000 Walker A motif; other site 1211025014001 ATP binding site [chemical binding]; other site 1211025014002 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1211025014003 Walker B motif; other site 1211025014004 arginine finger; other site 1211025014005 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1211025014006 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1211025014007 UbiA prenyltransferase family; Region: UbiA; pfam01040 1211025014008 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1211025014009 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1211025014010 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1211025014011 amphipathic channel; other site 1211025014012 Asn-Pro-Ala signature motifs; other site 1211025014013 glycerol kinase; Provisional; Region: glpK; PRK00047 1211025014014 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1211025014015 N- and C-terminal domain interface [polypeptide binding]; other site 1211025014016 active site 1211025014017 MgATP binding site [chemical binding]; other site 1211025014018 catalytic site [active] 1211025014019 metal binding site [ion binding]; metal-binding site 1211025014020 glycerol binding site [chemical binding]; other site 1211025014021 homotetramer interface [polypeptide binding]; other site 1211025014022 homodimer interface [polypeptide binding]; other site 1211025014023 FBP binding site [chemical binding]; other site 1211025014024 protein IIAGlc interface [polypeptide binding]; other site 1211025014025 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1211025014026 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1211025014027 putative active site [active] 1211025014028 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1211025014029 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1211025014030 FAD binding pocket [chemical binding]; other site 1211025014031 FAD binding motif [chemical binding]; other site 1211025014032 phosphate binding motif [ion binding]; other site 1211025014033 beta-alpha-beta structure motif; other site 1211025014034 NAD binding pocket [chemical binding]; other site 1211025014035 Predicted membrane protein [Function unknown]; Region: COG3152 1211025014036 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1211025014037 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1211025014038 triosephosphate isomerase; Provisional; Region: PRK14567 1211025014039 substrate binding site [chemical binding]; other site 1211025014040 dimer interface [polypeptide binding]; other site 1211025014041 catalytic triad [active] 1211025014042 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1211025014043 transmembrane helices; other site 1211025014044 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1211025014045 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 1211025014046 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1211025014047 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1211025014048 substrate binding pocket [chemical binding]; other site 1211025014049 membrane-bound complex binding site; other site 1211025014050 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1211025014051 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1211025014052 active site 1211025014053 ADP/pyrophosphate binding site [chemical binding]; other site 1211025014054 dimerization interface [polypeptide binding]; other site 1211025014055 allosteric effector site; other site 1211025014056 fructose-1,6-bisphosphate binding site; other site 1211025014057 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1211025014058 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1211025014059 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1211025014060 dimer interface [polypeptide binding]; other site 1211025014061 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1211025014062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025014063 active site 1211025014064 intermolecular recognition site; other site 1211025014065 dimerization interface [polypeptide binding]; other site 1211025014066 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1211025014067 DNA binding site [nucleotide binding] 1211025014068 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1211025014069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1211025014070 dimerization interface [polypeptide binding]; other site 1211025014071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025014072 dimer interface [polypeptide binding]; other site 1211025014073 phosphorylation site [posttranslational modification] 1211025014074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025014075 ATP binding site [chemical binding]; other site 1211025014076 Mg2+ binding site [ion binding]; other site 1211025014077 G-X-G motif; other site 1211025014078 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1211025014079 MOSC domain; Region: MOSC; pfam03473 1211025014080 3-alpha domain; Region: 3-alpha; pfam03475 1211025014081 superoxide dismutase; Provisional; Region: PRK10925 1211025014082 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1211025014083 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1211025014084 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1211025014085 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1211025014086 transcriptional activator RhaR; Provisional; Region: PRK13502 1211025014087 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1211025014088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025014089 transcriptional activator RhaS; Provisional; Region: PRK13503 1211025014090 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1211025014091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025014092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1211025014093 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1211025014094 N- and C-terminal domain interface [polypeptide binding]; other site 1211025014095 active site 1211025014096 putative catalytic site [active] 1211025014097 metal binding site [ion binding]; metal-binding site 1211025014098 ATP binding site [chemical binding]; other site 1211025014099 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1211025014100 carbohydrate binding site [chemical binding]; other site 1211025014101 L-rhamnose isomerase; Provisional; Region: PRK01076 1211025014102 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1211025014103 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1211025014104 intersubunit interface [polypeptide binding]; other site 1211025014105 active site 1211025014106 Zn2+ binding site [ion binding]; other site 1211025014107 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1211025014108 galactoside permease; Reviewed; Region: lacY; PRK09528 1211025014109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025014110 putative substrate translocation pore; other site 1211025014111 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1211025014112 Melibiase; Region: Melibiase; pfam02065 1211025014113 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1211025014114 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1211025014115 DNA binding site [nucleotide binding] 1211025014116 domain linker motif; other site 1211025014117 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1211025014118 ligand binding site [chemical binding]; other site 1211025014119 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1211025014120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1211025014121 non-specific DNA binding site [nucleotide binding]; other site 1211025014122 salt bridge; other site 1211025014123 sequence-specific DNA binding site [nucleotide binding]; other site 1211025014124 Cupin domain; Region: Cupin_2; cl17218 1211025014125 AzlC protein; Region: AzlC; cl00570 1211025014126 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1211025014127 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1211025014128 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025014129 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1211025014130 molybdopterin cofactor binding site; other site 1211025014131 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1211025014132 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1211025014133 molybdopterin cofactor binding site; other site 1211025014134 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1211025014135 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1211025014136 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1211025014137 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1211025014138 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1211025014139 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1211025014140 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1211025014141 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1211025014142 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1211025014143 RTX toxin acyltransferase family; Region: HlyC; pfam02794 1211025014144 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1211025014145 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1211025014146 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 1211025014147 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 1211025014148 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1211025014149 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1211025014150 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1211025014151 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1211025014152 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1211025014153 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 1211025014154 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 1211025014155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1211025014156 Coenzyme A binding pocket [chemical binding]; other site 1211025014157 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1211025014158 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1211025014159 putative active site [active] 1211025014160 dimerization interface [polypeptide binding]; other site 1211025014161 putative tRNAtyr binding site [nucleotide binding]; other site 1211025014162 hypothetical protein; Reviewed; Region: PRK01637 1211025014163 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1211025014164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1211025014165 motif II; other site 1211025014166 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1211025014167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1211025014168 DNA-binding site [nucleotide binding]; DNA binding site 1211025014169 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1211025014170 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1211025014171 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1211025014172 substrate binding site [chemical binding]; other site 1211025014173 ATP binding site [chemical binding]; other site 1211025014174 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1211025014175 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1211025014176 Class I aldolases; Region: Aldolase_Class_I; cl17187 1211025014177 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1211025014178 dimerization interface [polypeptide binding]; other site 1211025014179 putative active cleft [active] 1211025014180 alpha-glucosidase; Provisional; Region: PRK10426 1211025014181 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1211025014182 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1211025014183 putative active site [active] 1211025014184 putative catalytic site [active] 1211025014185 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1211025014186 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1211025014187 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1211025014188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1211025014189 putative substrate translocation pore; other site 1211025014190 outer membrane porin L; Provisional; Region: ompL; PRK09980 1211025014191 GTP-binding protein; Provisional; Region: PRK10218 1211025014192 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1211025014193 G1 box; other site 1211025014194 putative GEF interaction site [polypeptide binding]; other site 1211025014195 GTP/Mg2+ binding site [chemical binding]; other site 1211025014196 Switch I region; other site 1211025014197 G2 box; other site 1211025014198 G3 box; other site 1211025014199 Switch II region; other site 1211025014200 G4 box; other site 1211025014201 G5 box; other site 1211025014202 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1211025014203 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1211025014204 glutamine synthetase; Provisional; Region: glnA; PRK09469 1211025014205 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1211025014206 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1211025014207 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1211025014208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1211025014209 putative active site [active] 1211025014210 heme pocket [chemical binding]; other site 1211025014211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1211025014212 dimer interface [polypeptide binding]; other site 1211025014213 phosphorylation site [posttranslational modification] 1211025014214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1211025014215 ATP binding site [chemical binding]; other site 1211025014216 Mg2+ binding site [ion binding]; other site 1211025014217 G-X-G motif; other site 1211025014218 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1211025014219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1211025014220 active site 1211025014221 phosphorylation site [posttranslational modification] 1211025014222 intermolecular recognition site; other site 1211025014223 dimerization interface [polypeptide binding]; other site 1211025014224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1211025014225 Walker A motif; other site 1211025014226 ATP binding site [chemical binding]; other site 1211025014227 Walker B motif; other site 1211025014228 arginine finger; other site 1211025014229 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1211025014230 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1211025014231 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1211025014232 FeS/SAM binding site; other site 1211025014233 HemN C-terminal domain; Region: HemN_C; pfam06969 1211025014234 Der GTPase activator; Provisional; Region: PRK05244 1211025014235 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1211025014236 G1 box; other site 1211025014237 GTP/Mg2+ binding site [chemical binding]; other site 1211025014238 Switch I region; other site 1211025014239 G2 box; other site 1211025014240 G3 box; other site 1211025014241 Switch II region; other site 1211025014242 G4 box; other site 1211025014243 G5 box; other site 1211025014244 DNA polymerase I; Provisional; Region: PRK05755 1211025014245 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1211025014246 active site 1211025014247 metal binding site 1 [ion binding]; metal-binding site 1211025014248 putative 5' ssDNA interaction site; other site 1211025014249 metal binding site 3; metal-binding site 1211025014250 metal binding site 2 [ion binding]; metal-binding site 1211025014251 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1211025014252 putative DNA binding site [nucleotide binding]; other site 1211025014253 putative metal binding site [ion binding]; other site 1211025014254 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1211025014255 active site 1211025014256 catalytic site [active] 1211025014257 substrate binding site [chemical binding]; other site 1211025014258 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1211025014259 active site 1211025014260 DNA binding site [nucleotide binding] 1211025014261 catalytic site [active] 1211025014262 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1211025014263 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1211025014264 putative acyl-acceptor binding pocket; other site 1211025014265 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1211025014266 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1211025014267 catalytic residues [active] 1211025014268 hinge region; other site 1211025014269 alpha helical domain; other site 1211025014270 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1211025014271 serine/threonine protein kinase; Provisional; Region: PRK11768 1211025014272 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1211025014273 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1211025014274 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1211025014275 GTP binding site; other site 1211025014276 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1211025014277 Walker A motif; other site